Reaction product of selenium dioxide and aliphatic haloid carboxylic acids, method for making product, solution of product and therapy of benign, virus, premalignant and malignant nonmetastasing skin affections, dysontogenetic lesions of visible mucous membranes and other skin diseases

FIELD: medicine.

SUBSTANCE: invention refers to a new product in the form of solution for treatment of benign, virus, premalignant and malignant nonmetastasing skin affections, dysontogenetic lesions of visible mucous membranes, skin mycoses, wrinkle correction and senile pigment spots. The product represents a compound of general formula H2SeO3·x·[R-CXY-(CH2)m-COOH], where x=2-6 prepared from reaction of selenium dioxide and haloid carboxylic acids of general formula R-CXY-(CH2)m-COOH, where R = phenyl, alkyl of general formula CnH2n+1; n=1-5, X=H or Y, Y=F, CI, Br or J, m = 0-10. Besides, the invention concerns a product in the form of solution for treatment benign, virus, premalignant and malignant nonmetastasing skin affections, dysontogenetic lesions of visible mucous membranes, skin mycoses, wrinkle correction and senile pigment spots, containing 0.1-50 wt % of said product, 1-99 wt % of haloid carboxylic acids and the rest - water. Also the invention concerns method of treatment of various skin diseases, including topic applications of the product.

EFFECT: improved clinical effectiveness of the product and method of treatment.

6 cl, 3 dwg, 1 tbl, 68 ex

 

The invention can be used in dermatology, Oncology, urology genital, aesthetic medicine, plastic surgery, ophthalmology and gynecology.

It is now widely known and widely used such methods of treatment of various skin tumors as electric, plastic surgery, cryosurgery, radiation therapy, laser surgery, photodynamic therapy, therapy with interferon, chemotherapy, including Mohs method (the use of zinc chloride in combination with trichloroacetic acid), vaccination and the use of pharmaceutical drugs. However, these treatments are not always effective in obtaining a satisfactory result, especially in cases of multiple primary or recurrent tumors, due to the dissemination of malignant cells and tumor recurrence. In addition, for example, when surgical treatment methods have problems in the processing of lesions in the eyes, nose, genitals, develop irreversible complications, the formation of unsightly scars, keloids and binding, with dysfunction of organs.

However, along with the above methods and means of treatment is known to use as antineoplastic compounds selenium intended to prevent the sludge is palliative treatment of tumors of the internal organs, instead of skin and mucous membranes - see, in particular, U.S. patent No. 4824955, European patent No. 0095663 and some other sources.

The prior art also integrated selenay composition with galatarasay acid, is described in European application No. 1293498. However, the known composition is not selective, i.e. not only in neoplastic cells, affects healthy cells, causing necrosis. After treatment secondary infection occurs, there is a rough scars and keloids. The tumor is not completely eliminated, a high percentage of relapses.

The task underlying this invention is to further improve the anti-benign, viral, pre-malignant and malignant nemetstaticski lesions (tumors) skin, dysplastic lesions of the mucosa, as well as means for the correction of wrinkles and age spots, fungal infections of the skin and nails, by creating a composition for topical application, described below formula.

The clinical result is the lack of toxicity and side effects in the treatment of these lesions as benign, viral, pre-malignant and malignant nemetstaticescoy skin lesions, dysplastic (i.e. precancerous) lesions visible mucous about the next mouth, eyes, nose, genitals, and also for the correction of wrinkles and age spots, fungal infections of the skin and nails through their lifetime devitalisation.

This clinical result is the product of the interaction of selenium dioxide with aliphatic haloalkaline acids of General formula

R-CXY-(CH2)m-COOH,

where R = aryl, cycloalkyl, alkyl General formula CnH2n+1;

n=1-5, X=N or Y, Y=F, Cl, Br or J, m=0-10,

represents a compound of General formula

H2SeO3·x·[R-CXY-(CH2)m-COOH], where x=2-6.

This clinical result is also achieved by a method of manufacturing such a product, which malodorous acid or its aqueous solution was added selenium dioxide, stirred at a temperature of 20-215°C for 5-480 min and then filtered off from the precipitate.

The concentration of the aqueous solution haloalkaliphilic acids is preferably in the range 1-98 wt.%.

The reaction temperature is preferably 20-215°C.

To ensure prolonged action of the drug in the reaction mixture optionally, you can enter the compound from the class of hydroxy - and exocyclic [e.g., lemon(OH)(COOH)(CH2COOH)2, salicylic NOSE6H4COOH, dairy CH3CH(OH)COOH, pyruvic, CH3COCOON, the lion is Lanovoy, CH3PINES2CH2COOH, mesoxalic, (COOH)2and others] and other target additive in an amount of 0.1-10 wt.%.

This clinical result is also achieved by the solution of the above product containing 0.1 to 50 wt.% product 1-99 wt.% haloalkaliphilic acids and the rest is water.

This clinical result is also achieved by a method for the treatment of benign, viral, pre-malignant and malignant nematoctonus skin lesions, dysplastic lesions visible mucous membranes, the correction of wrinkles and age spots, as well as fungal infections of the skin and nails, comprising applying the above-mentioned product

When this product is used in the form of ointments, solution, cream, paste or gel.

The invention is illustrated by the following General methods and examples.

0.1-0.6 g-mol of concentrated malodorous acid special purification add 5 ml of water and 0.006-0.125 g-mol of selenium dioxide brand HTC, stirred at a temperature of 20-215°C for 20-480 min to almost complete dissolution of the precipitate, then cooled to room temperature and filtered through a glass filter G4. Get a clear solution, the color of which depending on the acid and its concentration varies from colourless to light yellow.

Example 1

To 45 ml of concentrated 2,2-is allocationally acid (62.5 g, 0,437 g-mole) was added 5 ml of distilled water and 0.66 g (0,006 g-mol) of selenium dioxide, is heated at a temperature of 105°C With stirring for 60 min, cooled to room temperature, filtered, and get a clear solution yellow.

Example 2

To 45 ml of concentrated 2-chloropropionate (56,6 g, 0,522 g-mol) of the acid, add 5 ml of distilled water and 0.66 g (0.006 g-mol) of selenium dioxide, is heated at a temperature of 90°C With stirring for 80 minutes, cooled to room temperature, was added 4.8 g (0.025 g-mole) of citric acid, [NOESN2C(OH)(COOH)CH2COOH=C6H8O7, M.V. 192], filter and get a clear solution straw color.

Example 3

To 45 ml of concentrated 6-chloropropanol acid (48,0 g, 0,319 g-mole) was added 5 ml of distilled water and 0.66 g (0,006 g-mol) of selenium dioxide, is heated at a temperature of 200°C under stirring for 30 min, cooled to room temperature, filtered, and get a clear solution is light yellow.

Example 4

To 45 ml of concentrated 9-chlorophenol acid [ClCH2(CH2)8COOH, C10H19ClO2, M.V. 206,4] (46,0 g, 0,223 g-mole) was added 5 ml of distilled water and 0.66 g (0,006 g-mol) of selenium dioxide, is heated at a temperature of 215°C With stirring for 20 min, cooled to room so the temperature, filter and get a clear solution straw color.

Example 5

To 45 ml of concentrated 2-iodopropionic (mV 199,95, 77,2 g, 0,386 g-mol) of the acid, add 5 ml of distilled water, 4.5 g (0.05 g-mole) breast [CH3CH(OH)COOH, C3H6About3, mV 90] acid and 6.9 g (0.05 g-mole) of salicylic acid [NOSE6H4COOH, C7H6About3mV 138] and 0.66 g (0,006 g-mol) of selenium dioxide, is heated at a temperature of 20°C With stirring for 40 min, cooled to room temperature, filtered, and get a clear solution yellow.

Conditions for reactions with other haloalkaline acids presented in the table.

In the presence of excess free acid it can be viewed as the solution of H2S3in the corresponding malodorous acid, which was confirmed by NMR spectra high resolution on nuclei1H,13C and77Se.

As an example, in figure 1-3 shows the NMR spectra-1H (600 MHz)NMR13-{1N} (150 MHz) spectrum and NMR77Se (114,45 MHz), a drug derived from the 2.2-dichloropropionic acid.

1 shows an NMR spectrum-1H (600 MHz spectrometer (BRUKER AVANCE-600) preparation of N2S3·x·(CH3CCl2COOH). Chemical shifts in δ-scale. The ratio of integrated intensities si the channels CH 3group (with a 1.96 ppm) and COOH-groups (10,8 ppm) allows to determine the ratio of the concentrations of acid and water.

Figure 2 shows an NMR spectrum-13-{1N} preparation H2S3·x·(CH3CCl2COOH).

Chemical shifts in δ-scale.

Classification of signals: 34,9 ppm -CH3CCl2COOH; 81,4 ppm - CH3CCl2COOH;

169,23 ppm - CH3CCl2WithUN.

Figure 3 shows an NMR spectrum-77Se-{1N} preparation H2S3·x·(CH3CCl2COOH).

(114,45 MHz spectrometer BRUKER AVANCE-600)

The mass fraction of selenium dioxide, malodorous acid and water in drugs for the treatment of various skin diseases can vary in the range of 0.1-25 wt.% for SeO2, 1-99 wt.% for acid R-CXY-(CH2)m-COOH and 1-99 wt.% for water, depending on the medical application.

The claimed compound is a clear, colorless, slightly viscous liquid, acidity is in the range of pH from 0.8 to 6.9. Chemically and biologically stable for at least five years, is non-toxic. The concentration of selenium in the composition depends on the chemical components and is in the range from 1.0 to 10000 mg/l, while the composition is intended only for topical (i.e. local) applications in the form of applications. The recommended dose when simultaneously used with the rod depends on the size of the lesion (for example, tumors) and may vary from 0.01 to 0.2 ml using anhydrous form to it before use, add distilled water.

The composition of the system has no teratogenic, embryotoxic or carcinogenic properties that are not absorbed by the body (absorption into the blood is not), because the limits of its influence is limited only by the scope of the treated lesion pathologically changed tissues. In the application process is immediate dehydration and intravitally fixation of the tissue, which is included in the contact. Visually, the initial effect of composition manifests in the form of discoloration diseased tissue on the white-yellowish-gray and appearance around her swelling and redness of the surrounding skin or visible mucous. Microscopically at this moment around the treated area was observed infiltration of mononuclear cells, micro - and macrophages. In the following, devitalizirovannaya pathological tissue modifitsiruetsya (dries), changing the color to dark brown. Mummified scabs separated only after a complete revitalizatio spontaneously in 2-3 weeks. Healing goes without complications, especially in the absence of secondary infection, leaving a significant scars, deformations adjacent tissues or impaired function of organs. Means the selected side effects, as well as any contraindications in laboratory and clinical trials not identified. You should also add that the mechanism of therapeutic action of the inventive composition for the treatment of all of the above lesions of the skin and visible mucous, as well as the correction of wrinkles and age spots similar, except that the correction of wrinkles and age spots achieved with a less concentrated solution of the compound (1-20%)than that used for treatment of skin lesions and mucous (21-99%).

The above described mechanism of action of the composition due to its intravitally locking action, immunomodulatory and antiangiogenic properties, the ability to interrupt the growth and activity of malignant Hyper-, meta - and dysplastic cells, through:

a) angiological, dehydration and selective devitalisation of pathologically altered cells and tissues, skin tumors and dysplastic lesions visible mucous membranes;

b) local immunostimulating and General immune-modulating activity;

in) antineoplastics, antibacterial and antiviral activities;

g) accelerated regeneration and revitalizatio healthy skin and mucous membranes surrounding tumor tissue.

The composition of causes associated signal transduction in macrophages and mononuclear which the blood cells, infiltrating the tumor-surrounding tissue, intravitally the obliteration and coagulation of the blood vessels supplying blood to the tumor and lymph vessels engaged in the lymphatic drainage of the tumor. The composition is an effective stimulator of local immunity, reducing the impact of immunosuppression associated with tumor development.

According to experimental, immunological, histochemical, electron microscopic studies have established that the claimed composition after topical application, in addition to selective devitalizing impact on the pathologic lesion that can cause two possible categories of immune responses:

a) innate (nonspecific) immune response, activating granulocytes, micro and macrophages, phagocytosis, which are known to be capable of producing cytokines, antitumor and antimicrobial peptides;

b) adaptive (specific) immune response occurring more slowly, but a specific reaction, with the formation of activated T - and b-lymphocytes. Clinically, it manifests itself as a transient form of intense local immune reaction, flushing, hyperthermia, edema, induration, but without necrosis, secondary infection, ulcerations, which do not require additional medical procedures, because they are C the protective reactions of an organism.

Summarizing the benefits of using composition, you can highlight the main results:

treatment using jeleniewo composition due to its selective penetration and local devitalizing action is limited to local changes of neoplastic tissues and their subsequent self-rejection, without the formation of any significant (visible) scars;

- the treatment does not require anesthesia, has no damaging effect on the surrounding healthy areas and can be carried out on an outpatient basis, without limiting the daily activities of the patient.

The examples below reflect the results of experimental and clinical trials, as well as the practical application of the claimed composition in the treatment of various neoplastic skin lesions and dysplastic lesions of the mucous membranes, as well as fungal infections of the skin and nails. It should be noted that the term "jeleniewo connection" in the instructions, under No. 7-10, 16, 17, 25, 27, 36, 42, 44, 52, 56, 63 was applied selenium compound with monochloropropane acid, in the instructions, under No. 2-6, 13-15, 18-20, 28-33, 35, 39, 45, 48, 53, 54, 57, 60, 61, 67, 68 selenium compound with dichloropropionic acid, in the instructions, under№№22, 46, 55, 66 - connection selenium with pentafluoropropionic acid, in the instructions, under№№11, 12, 23, 24, 37, 40, 51, 62, 65 - selenium compound with moneytrain the howling acid, in the instructions, under№№1, 21, 22, 34, 38, 41, 47, 50, 64 - selenium compound with monobromobimane acid, in the instructions, under No. 26, 49, 59 - selenium compound with chloropropanol acid, and in the instructions, under No. 43, 58 - selenium compound with chloroprene acid (*the names of the diseases given in accordance with the histological classification of tumors of the skin (who, 1996):

1. Genital warts*.

2. Nutritionally melanocytic nevus*

3. Epidermally nevus*

4. Seborrheic keratosis*

5. Borderline melanocytic nevus*

6. Cream melanocytic nevus*

7. Halo nevus*

8. Spitz nevus*

9. Pigmented ureterolithotomy reed nevus*

10. Cellular blue nevus*

11. Congenital melanocytic nevus*

12. Dysplastic melanocytic nevus*

13. Superficial spreading melanoma*, in situ

14. Melanoma is a type of malignant lentigo*, 1 stage

15. Anchor modular melanoma*, in situ

16. Lentigo simple (simplex)*

17. Inflammatory linear verrucous epidermal nevus*

18. Clear of acanthoma*

19. Cutaneous horn

20. Keratoakantoma*

21. A simple wart*

22. Plantar wart*

23. Flat wart*

24. Molluscum contagiosum*

25. Radiation keratosis*

26. ARSENICAL keratosis

27. Oral leukoplakia

28. Vnutriepetelialnaya of ploscockletocny the cancer*, 1, stage 2

29. Infiltrating squamous cell carcinoma*, 1, 2 stage

30. Modular basal cell cancer*, 1, 2 stage

31. Superficial basal cell cancer*, 1, 2 stage

32. With metatypical carcinoma skin cancer*

33. Syringoma*

34. Adenoma of sebaceous glands*

35. Pigmented hairy epidermal nevus

36. Nevus seborrheic*

37. Trichoepithelioma*

38. Trichotillimania*

39. Pigmented basal cell cancer*, 1, 2 stage

40. Cyst funnel*

41. Capillary malformation (Unna nevus)*

42. Nevus flaming*

43. Nevus teleangiectasia

44. Venous malformation (blue bubble nevus)*

45. Angiokeratoma*

46. Pyogenic granuloma*

47. Capillary hemangioma*

48. Kaposi's sarcoma*, 1 stage

49. Cystic lymphangioma*

50. Fibroma*

51. Xanthoma*

52. Fibrous papule*

53. Primary cutaneous naranzaria carcinoma (tumor cells Merkel)* 1, stage 2

54. Neurofibromatosis - ectodermal form

55. Fibroepithelial polyp*

56. Warty dyskeratosis*

57. Both of acanthoma

58. Benign elsewedy keratosis*

59. Tar keratosis

60. Warty squamous cell carcinoma*

61. Seborrheic carcinoma*, 1, 2 stage

62. Angiolymphoid hyperplasia with eosinophilia (epithelioma hemangioma)*

63. Benign F. brosna histiocytoma*

64. Atypical of fibroxanthoma*, 1 stage

65. Hair tumor (proliferously trichilemmal cyst)*

66. Lipomatosis nevus

67. Wrinkles of the skin

68. A fungal infection of the skin and nails

Summary No. 1

Patient B., born in 1986, came in RCRC and PS (Moscow) against the occurrence of warts under the foreskin of the penis. Disease duration was 1.5 months. When viewed on the inner leaflet found at four soft warty fibroepithelial education on a narrow pedicle skin color, with the protuberances resembling cauliflower, size of 4.0×3,0×2.0 mm, and 2.5×2,0×2.5 mm, and 3.0×2,5×2.0 mm and 5.0×3,5×3,0 mm When conducting DNA-diagnostics of scraping with existing warts identified the human papilloma virus 16 (HPV 16). Clinical analysis of blood and urine without pathological deviations. TPHA Treponema antigen palliduum, REEF and Wasserman - negative. Conclusion dermatologist: genital warts. Performed a biopsy of one of the warts. The histological conclusion: genital warts. After obtaining the consent of the patient, without anesthesia, performed applique selenium composition on HPV, in a dose of 0.1 ml 15 minutes after application genital warts are yellowed around them there was a small swelling and redness of the skin after 24 hours of HPV darkened and mummified. After 12-14 d is she after treatment HPV freely separated from the skin of the foreskin, on the site of their attachment to the skin, within 30-36 days, was observed areas of redness on the area corresponding to the area of the base of the warts. Subsequent observation of the patient during the period did not reveal recurrence of warts.

Report No. 2

Patient X. (1975), applied to RCRC and PS (Moscow) with a complaint about the presence of a birthmark in the lower abdomen, travelouges when wearing clothes. According to the patient birthmark prevented him from childhood. Previously consulted an oncologist recommended the removal of the birthmark. Objective examination on the anterior abdominal wall in the lower third of almost in the midline of the abdomen had papillomatoses education oval 2.4 x 1.2 cm in size, with a strong leg brown, painless on palpation. Conclusion dermatologist after inspection: nutritionally nevus. Performed a biopsy of the nevus. The histological conclusion: nutritionally melanocytic nevus. Given the large size of the nevus and its permanent trauma, it was decided to produce the destruction of the nevus selenium composition. After obtaining the consent of the patient, without anesthesia, performed applique jeleniewo composition on nevus, in a dose of 0.1 ml 15-20 minutes Later nevus changed the color to a more yellow-grey, in 25-30 minutes around nevus appeared thin strip hyperemic skin, and after 24 Casanovas went black and mummified. Any General toxicity or other side effects were observed. In the period from 14 days to 24 days after application, mummified tissue nevus separated from the underlying skin. On the location of the nevus was exposed the plot hyperemic skin, then, slowly, over 30-50 days has become normal for the surrounding skin color. Subsequent observation of the patient did not reveal any pathological changes in the skin at the location of the nevus or other skin areas.

Report No. 3

Patient S. born in 1971, has addressed in clinic of aesthetic medicine gcaron (Israel) against the presence of tumor formation on the left shoulder. Disease duration was a few years. When viewed on the flexor surface of the shoulder in the upper third was defined granulomas formation in the form of a plaque bodily color, round shape with a diameter of 1.5 cm, on a narrow base, with a rough surface, protruding above the skin up to 0.5 cm was examined by a dermatologist, conclusion: papillomatosis soft epidermal nevus. Performed a biopsy of the nevus, the histological conclusion: epidermal nevus. With the consent of the patient is made applique jeleniewo composition on nevus, in a dose of 0.1 ml Over 20 minutes after application the surface of the nevus has acquired a yellowish-gray color. After 30 minutes havelse slight swelling of the skin around nevus, and after 24 hours was observed darkening and mummification of the nevus. While there have been no systemic toxicity or side effects. After 25 days mummified scabs nevus spontaneously separated from the underlying skin. On the location of the nevus, within 40 days, was observed area of redness on the area corresponding to the area applications selectabase drug. Subsequent observation of the patient did not reveal any pathological changes of the skin on the location of the nevus.

Report No. 4

Patient N. born in 1950, has addressed in clinic of aesthetic medicine gcaron (Israel) against the occurrence of flat warty education on the scalp in the area of the ear. Disease duration was more than 10 years. When viewed on the back of the head to the left behind the ear was determined by the formation of irregular size of 3.3×2.8 cm, with a rough warty surface, sharp edges, yellowish-brown protruding above the skin for 3-4 mm, covered with a greasy crusts. Consulted a dermatologist conclusion: seborrheic keratosis. Performed a biopsy of the specified area of the skin, the histological conclusion: seborrheic keratosis. After obtaining the consent of the patient, without anesthesia, performed applique selectabase of the drug to the affected keratosis skin in doses is of 0.1 ml. 15 minutes after application the treated surface of the skin changed color to gray, 20-25 minutes around her appeared a thin strip of redness and slight swelling, but after 24 hours occurred darkening and mummification modified keratosis skin. After 24 days after application mummified scabs fragments separated from the underlying skin. On location, within 48 days, there has been an area of moderate hyperemia area, the corresponding area of application selectabase drug. Subsequent observation of the patient did not reveal any pathological changes in the skin at the location of seborrheic keratosis.

Report No. 5

The patient Was born in 1982 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of a birthmark on the palm of the right hand. Specified birthmark appeared shortly after birth, gradually increasing in size. When viewed on the Palmar surface of the right hand was determined stain brown with a diameter of 11 mm, evenly pigmented, without hair. Conclusion dermatologist: nevus. Performed a biopsy of the nevus, the histological conclusion: borderline melanocytic nevus. Given melanomatosis localization border nevus, it was decided to hold its local destruction with jeleniewo from the tava. After obtaining the consent of the patient is made applique jeleniewo composition on nevus, in a dose of 0.1 ml Over 20 minutes after application the surface of the nevus has acquired a yellowish-gray color. After 25 minutes, there was little swelling of the skin around the nevus, and after 20 hours was observed darkening and mummification of the nevus. While there have been no systemic toxicity or side effects. After 25 days mummified scabs spontaneously separated from the Palmar surface. On the location of the nevus, for 50 days, there has been an area of redness on the area corresponding to the area applications selectabase drug. Subsequent observation of the patient during the period did not reveal any pathological changes of the skin on the location of the nevus.

Report No. 6

Patient L., born in 1986 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of a birthmark on the back. The specified spot marked with the child's age. When viewed on the back left mid-scapular line at the level of the 8th rib was determined pigmented papule oval shape with a diameter of 5×6 mm, without hair. Conclusion dermatologist: nevus. Performed a biopsy of the nevus, the histological conclusion: mixed melanocytic nevus. Given the increased trauma nevus underwear, it was decided to hold homestay destruction using jeleniewo composition. After obtaining the consent of the patient, made applique jeleniewo composition on nevus, at a dose of 0.05 ml After 20 minutes after application the surface of the nevus has acquired a yellowish-gray color. After 25 minutes, there was little swelling of the skin and strip the redness around the nevus and the next day was observed darkening and mummification of the nevus. While there have been no systemic toxicity or side effects. After 22 days mummified scabs have separated from the underlying skin. On the location of the nevus, for 50 days, there has been an area of redness on the area corresponding to the area applications selectabase drug. Subsequent monitoring of the patient did not reveal any pathological changes of the skin on the location of the nevus.

Report No. 7

The patient Century. born in 1972 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of a birthmark on my left forearm. The specified spot appeared after pregnancy in 2000, When viewed on the outer surface of the left forearm in the middle third were determined papule, brown round shape with a diameter of 4 mm, around which there was an area of depigmented skin with a diameter of 11 mm, an opinion of a dermatologist: halo nevus. Performed a biopsy of the nevus, the histological conclusion: nevus with features of inflammatory infil the ation. Considering the results of the histological study and desire of the patient, it was decided to hold the local destruction of the nevus with jeleniewo composition. After obtaining consent, made applique selectabase drug nevus, at a dose of 0.05 ml 15 minutes after application the surface of the nevus has acquired a yellowish-gray color. After 25 minutes, there was little swelling of the skin and strip the redness around the nevus and the next day was observed darkening and mummification of the nevus. While there have been no systemic toxicity or side effects. 28 days later mummified scabs have separated from the underlying skin. On the location of the nevus, for 50 days, there has been an area of redness on the area corresponding to the area applications selectabase drug. Subsequent monitoring of the patient during the period did not reveal any pathological changes of the skin on the location of the nevus.

Report No. 8

Patient A. 1994 addressed to the clinic of aesthetic medicine gcaron (Israel) against the appearance of a lump on the forehead. The specified bundle appeared a few months ago and quickly increases in size. When viewed in the forehead right above the eyebrow was determined hemispherical site pink color, with a smooth surface diameter of 5 mm, without hair. Conclusion dermatologist is: Spitz nevus. 15.12.2003, performed a biopsy of the nevus, the histological conclusion: ureterolithotomy nevus. Considering the results of the histological examination and the persistent request of the parents of the patient, it was decided to hold the local destruction of the nevus with jeleniewo composition. After obtaining the consent of the patient and his parents made applique selectabase drug nevus, at a dose of 0.05 ml 15 minutes after application the surface of the nevus has acquired a yellowish-gray color. After 20 minutes there was little swelling of the skin around the nevus, and after 20 hours was observed darkening and mummification of the nevus. While there have been no systemic toxicity or side effects. After 23 days mummified scabs spontaneously separated from the underlying skin. On the location of the nevus, within 40 days, was observed in the area of hyperemia, and then increased pigmentation of the skin, the area corresponding to the area applications selectabase drug. Subsequent observation of the patient during the period did not reveal any pathological changes of the skin on the location of the nevus.

Report No. 9

The patient Century. born in 1971 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of pigmented plaques on the right thigh. This plaque appeared several years before treatment. When OS the handle on the front surface of the right thigh in the upper third was determined blue-black papule, rounded shape with a diameter of 6 mm, an opinion of a dermatologist: nevus of reed. Performed a biopsy of the nevus, the histological conclusion: pigmented ureterolithotomy nevus of reed. Considering the results of the histological study and desire of the patient, it was decided to hold the local destruction of the nevus with jeleniewo composition. After obtaining consent, made applique selectabase drug nevus, at a dose of 0.05 ml 15 minutes after application the surface of the nevus has acquired a yellowish-gray color. After 25 minutes, there was little swelling of the skin and strip the redness around the nevus and the next day was observed darkening and mummification of the nevus. While there have been no systemic toxicity or side effects. After 30 days mummified scabs have separated from the underlying skin. On the location of the nevus, within 45 days, was observed area of redness on the area corresponding to the area applications selectabase drug. Subsequent monitoring of the patient during the period did not reveal any pathological changes of the skin on the location of the nevus.

Report No. 10

Patient S. born in 1970 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of pigmented node on the left buttock. The specified node appeared in 15 years of age. During the inspection n the left gluteal region in the outer-lower quadrant was determined by the host blue with a rough surface is rounded, with a diameter of 2.5 mm. Conclusion dermatologist: blue nevus. Performed a biopsy of the nevus, the histological conclusion: cellular blue nevus. Considering the results of the histological examination and the size of the nevus, it was decided to hold the local destruction of the nevus with jeleniewo composition. After obtaining the consent of the patient, made applique jeleniewo composition on nevus, at a dose of 0.2 ml in 15 minutes after application the surface of the nevus has acquired a yellowish-gray color. After 25 minutes, appeared moderate edema of the skin and strip the redness around the nevus and the next day was observed darkening and mummification of the nevus. While there have been no systemic toxicity or side effects. After 42 days mummified scabs nevus separated from the underlying skin. On the location of the nevus, within 60 days, was observed plot retraction and hyperemia of the skin area, the corresponding area of application selectabase drug. Subsequent observation of the patient during the period did not reveal any pathological changes of the skin on the location of the nevus.

Report No. 11

Patient I. (1975) has referred to the clinic of aesthetic medicine gcaron (Israel) against the presence of a large birthmark on the back. Specified birthmark was detected immediately Ave the birth and increased in size as it grows. When viewed on his back in the interscapular area with the transition in the right axillary region had education with warty surface with uneven color brown, size 28×24 cm, covered with hair. Conclusion dermatologist: congenital giant hairy nevus. Performed a biopsy of the nevus, the histological conclusion: congenital melanocytic nevus. Considering the results of the histological examination and the size of the nevus, it was decided to hold the local destruction of the nevus with jeleniewo composition. After obtaining the consent of the patient, made applique jeleniewo composition on nevus, in a dose of 1.8 ml. in 15 minutes after application the surface of the nevus has acquired a yellowish-gray color. After 25 minutes, appeared moderate edema of the skin and a thin strip of redness around the nevus and the next day was observed darkening and mummification of the nevus. While there have been no systemic toxicity or side effects. In the period from 35 to 45 days after application were observed exfoliation mummified scabs nevus from the underlying skin. On the location of the nevus, within 60 days, was observed in the area of hyperemia of the skin with subsequent pigmentation area, the corresponding area of application selectabase drug. Subsequent observation of the patient did not reveal any pathologist the economic changes of the skin on the location of the nevus.

Report No. 12

The patient Century. born in 1963 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of pigment spots on the skin of the back. These spots appeared two years before treatment. The father of the patient was treated for melanoma. When seen on the skin of the back on the right half of the level of the 10th rib were three education with a rough warty surface, with variegated coloration dark brown, with indistinct borders, with a diameter of 7.0, 6.0 and 5,5 mm. At the base of the formations was determined by the zone of hyperemia. Conclusion dermatologist: dysplastic nevus. Performed a biopsy of the nevus, the histological conclusion: dysplastic melanocytic nevus. Considering the results of the histological study, high melanomatosis nevus, it was decided to hold the local destruction of the nevus with jeleniewo composition. After obtaining the consent of the patient, made applique jeleniewo composition on nevus, in a dose of 0.25 ml After 20 minutes after application the surface of the nevus has acquired a yellowish-gray color. After 25 minutes, appeared moderate edema of the skin and a thin strip of redness around the nevus and the next day was observed darkening and mummification of the nevus. While there have been no systemic toxicity or side effects. In the period from 40 to 45 days after application were observed exfoliation of modifica avannah scabs nevus from the underlying skin. On the location of the nevus, within 60 days, was observed in the area of hyperemia of the skin with subsequent pigmentation area, the corresponding area of application selectabase drug. Subsequent observation of the patient did not reveal any pathological changes of the skin on the location of the nevus.

Report No. 13

Patient D., born in 1967 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of brown spots on the right leg. The existence of spots according to the patient were calculated for a period of more than 15 years, but over the last 5-6 months it was noted discoloration spots and increase its area. When viewed on the outer surface of the right tibia in the top third had a stain brown with a pinkish-gray and black points, slightly above the level of the skin, with sharp irregular edges and a ring of redness around the spot size of 7×8 mm, with a glossy surface. After consulting a dermatologist suspects melanoma was performed biopsy, the histological conclusion: superficial spreading melanoma, I stage. Considering the results of the histological examination, it was decided to hold the local destruction of melanoma using jeleniewo composition. After obtaining the consent of the patient was performed applique jeleniewo who had a tumor at a dose of 0.2 ml After 20 minutes after application the surface of the tumor acquired a yellowish-gray color. After 30 minutes appeared moderate edema of the skin and strip hyperemia around the tumor, and after 20 hours was darkening and mummification. While there have been no systemic toxicity or side effects. In the period from 40 to 45 days after application were observed exfoliation mummified scabs tumor from the subject's skin. On the location of the nevus, within 60 days, was observed in the area of hyperemia of the skin with subsequent pigmentation area, the corresponding area of application selectabase drug. Observation of the patient during the period did not reveal any pathological changes in the skin at the location of the tumor or its metastases in the surrounding areas of the skin, the nearby lymph nodes or metastases to distant organs and tissues.

Report No. 14

Patient J. born in 1940 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of brown spots on the skin of the neck. The specified spot appeared a few years ago before going, however, in the last 2-3 years it began to grow in size. When viewed on the side of the neck to the left there was a brown stain seats black, with dull surface of irregular shape with sharp edges, size is 36×42 mm Conclusion of dermatology: melanoma is a type of malignant lentigo. Performed a biopsy of the tumor, the histological conclusion: melanoma is a type of malignant lentigo. Considering the results of the histological examination, it was decided to hold the local destruction of melanoma using jeleniewo composition. After obtaining the consent of the patient was performed applique jeleniewo composition to the tumor at a dose of 0.2 ml in 15 minutes after application the surface of the tumor acquired a yellowish-gray color. After 20 minutes, appeared moderate edema of the skin and strip hyperemia around the tumor, and a day was darkening and mummification. While there have been no systemic toxicity or side effects. In the period from 40 to 50 days after application were observed exfoliation mummified scabs tumor from the subject's skin. At the location of the tumor within 60 days, was observed in the area of hyperemia of the skin with subsequent pigmentation area, the corresponding area of application selectabase drug. Observation of the patient during the subsequent period did not reveal any pathological changes in the skin at the location of the tumor or its metastases in the surrounding areas of the skin, the nearby lymph nodes or metastases to distant organs and tissues.

Report No. 15

Patient S. born in 1949 about ratilla in aesthetic medicine clinic gcaron (Israel) with a complaint of formation of brown color on the skin of the chest. The specified node appeared at the place birthmark about a year ago, the last two months started to increase rapidly. When viewed on the front surface of the chest right above the nipple on average clavicle line there was a host of a light-brown color with clear boundaries round shape 6 mm diameter with a smooth shiny surface. Conclusion dermatologist: nodular melanoma. Was performed the biopsy, the histological conclusion: nodal modular melanoma, I stage. Considering the results of the histological examination, it was decided to hold the local destruction of melanoma using jeleniewo composition. After obtaining the consent of the patient was performed applique jeleniewo composition to the tumor at a dose of 0.2 ml in 20 minutes after application the surface of the tumor acquired a yellowish-gray color. After 25 minutes, appeared moderate edema of the skin and strip hyperemia around the tumor, and after 24 hours was darkening and mummification. While there have been no systemic toxicity or side effects. In the period from 40 to 42 days after application were observed exfoliation mummified scabs tumor from the subject's skin. On the location of the tumor, within 55 days, there has been an area of hyperemia of the skin with subsequent pigmentation area, the corresponding area of application selenidera the m product. Subsequent observation of the patient during the period did not reveal any pathological changes in the skin at the location of the tumor or its metastases in the surrounding areas of the skin, the nearby lymph nodes or metastases to distant organs and tissues.

Report No. 16

Patient O. born in 1987 went to the clinic of aesthetic medicine gcaron (Israel) against the appearance of dark brown spots on the back. These spots appeared at the age of 9-10 years, but were small, poorly pigmented and did not cause concern. The last 3-4 months stains darkened and grew in size. When viewed on the back on the left at the level of 6-7 ribs were determined three pigmented spots, dark brown color, with sharp edges, rounded shape with a diameter of 6.0, 8.0 and 9.0 mm, without hair. Conclusion dermatologist: youth lentigo. Performed a biopsy of one of the spots, the histological conclusion: lentigo simple (simplex). Considering the results of the histological study and desire of the patient, it was decided to hold the local destruction of pigmented spots using jeleniewo composition. After obtaining the consent of the patient, made applique jeleniewo composition on the spot, at a dose of 0.15 ml 15 minutes after application the surface stains acquired a yellowish-gray color. After 20 minutes there was little swelling of the skin and strip hyperim and around spots, and one day there was a darkening and mummification. While there have been no systemic toxicity or side effects. After 25 days mummified scabs have separated from the underlying skin. On the location of the spots, for 38 days, there has been an area of redness on the area corresponding to the area applications selectabase drug. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of lentigo.

Report No. 17

Patient Z. (1975) has referred to the clinic of aesthetic medicine gcaron (Israel) against the presence of itchy nodules on the left thigh. These nodules appeared in childhood, repeated attempts their local treatment had no effect. When viewed on the rear surface of the left femur in the upper and middle thirds were determined linearly spaced parasitologie papules. Consulted a dermatologist conclusion: inflammatory linear verrucous epidermal nevus. Performed a biopsy of the nevus, the histological conclusion: inflammatory linear verrucous epidermal nevus. With the consent of the patient is made applique jeleniewo composition on nevus, in a dose of 0.1 ml 15 minutes after application the surface of the nevus has acquired a yellowish-gray color. After 30 minutes there was little swelling of the skin is around the nevus, and after 24 hours was observed darkening and mummification of the nevus. While there have been no systemic toxicity or side effects. After 21 days mummified scabs nevus spontaneously separated from the underlying skin. On the location of the nevus, within 45 days, was observed area of redness on the area corresponding to the area applications selectabase drug. Subsequent monitoring of the patient did not reveal any pathological changes of the skin on the location of the nevus.

Report No. 18

The patient Century. born in 1942 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of tumor on the right leg. The tumor appeared several years before treatment. When viewed on the outer surface of the right tibia in the middle third were determined dome-shaped tumor, rounded shape with a diameter of 8 mm, brown, with a rough surface. Around education was defined area of skin peeling, partially covered with crusts. Conclusion dermatologist: clear acanthoma. Performed a biopsy of the tumor, the histological conclusion: clear acanthoma. Considering the results of the histological study and desire of the patient, it was decided to hold the local destruction of the tumor using jeleniewo composition. After obtaining consent, executed by applicati selectabase of the drug on the tumor, in a dose of 0.1 ml After 17 minutes after application the surface of the tumor acquired a yellowish-gray color. After 25 minutes, there was little swelling of the skin and strip hyperemia around the tumor, and the next day was observed darkening and her mummification. While there have been no systemic toxicity or side effects. After 36 days mummified scabs tumor was separated from the underlying skin. On the location of the tumor, within 56 days, was observed in the area of hyperemia and retraction of the skin on the area corresponding to the area applications selectabase drug. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of the tumor.

Report No. 19

Patient X. born in 1948 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of tumor in the forehead. The tumor appeared several years before treatment, gradually increasing in size. When seen on the skin of the left superciliary area was determined with a cone-shaped tumor reddish-pink color, with a smooth surface, thick consistency, with a diameter of 4.0 mm and a height of 6.0 mm, an opinion of a dermatologist: cutaneous horn. Performed a biopsy of the tumor, the histological conclusion: cutaneous horn. Considering the results of the histological examination and the patient, it was decided to hold the local destruction of tumor using jeleniewo composition. After obtaining the consent of the patient, made applique jeleniewo composition to the tumor at a dose of 0.1 ml Over 20 minutes after application the surface of the tumor acquired a yellowish-gray color. After 25 minutes, there was little swelling of the skin and strip hyperemia around the tumor, and the next day there was a darkening and mummification. While there have been no systemic toxicity or side effects. After 35 days mummified scabs tumor was separated from the underlying skin. On the location of the tumor, within 48 days, there has been an area of redness on the area corresponding to the area applications selectabase drug. Subsequent observation of the patient did not reveal any pathological changes in the skin at the location of cutaneous horns.

Report No. 20

Patient S. born in 1949 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of tumor on the right cheek. Described the tumor appeared five months ago and quickly grew in size. When seen on the skin of the right cheek had a tumor of the dome shape, with a diameter of 2.1 cm, purple color with crateriform hollow in the center, filled ceratozamia masses of gray-brown color. Around the tumor was determined dense cushion pink. Conclusion dermatologist: giant keratoacanthoma is. Performed a biopsy of the tumor, the histological conclusion: keratoakantoma at the stage of stabilization. Considering the results of the histological study and desire of the patient, it was decided to hold the local destruction of tumor using jeleniewo composition. After obtaining the consent of the patient is made applique jeleniewo composition to the tumor at a dose of 0.2 ml in 15 minutes after application the surface of the tumor acquired a yellowish-gray color. After 25 minutes, there was little swelling of the skin around the tumor, and after 24 hours was observed darkening and mummification of the tumor. While there have been no systemic toxicity or side effects. After 32 days mummified scabs tumors spontaneously separated from the underlying skin. On the location of the tumor, within 50 days, was observed in the area of hyperemia, and then increased pigmentation of the skin, the area corresponding to the area applications selenium composition. Subsequent monitoring of the patient showed no recurrence of the tumor.

Report No. 21

Patient Z. born in 1977, has addressed in clinic of aesthetic medicine gcaron (Israel) against the presence of warts on the skin of the right hand. These warts appeared a few months ago, increasing in number and size. When viewed on the rear surface of the right hand about 1-St and 2-what about the fingers was determined by multiple dense epidermal papules rounded shape with a diameter of 1.0 to 5.0 mm, the rough surface of a pale pink color. Conclusion dermatologist: simple warts. Performed a biopsy of the largest warts, the histological conclusion: a simple wart. By agreement with the patient is made applique jeleniewo composition on warts, at a dose of 0.15 ml 15 minutes after application the surface of the warts acquired a yellowish-gray color. After 25 minutes, there was little swelling of the skin around the wart, and 20 hours later there was a darkening and mummification. While there have been no systemic toxicity or side effects. After 22 days mummified scabs warts spontaneously separated from the underlying skin. On the location of the warts, within 42 days, was observed areas of redness on the area corresponding to the area applications selenium composition. Subsequent monitoring of the patient after treatment did not reveal any pathological changes in the skin at the location of the wart or their recurrence.

Report No. 22

Patient C. born in 1980, has addressed in clinic of aesthetic medicine gcaron (Israel) against the presence of warts on the heel of the left leg. These warts appeared about 1 year ago, after injury to the skin of the foot. When viewed on the plantar surface of the left foot in the heel area had three tight spans the project for a round shape with clear boundaries in diameter 6,0, 8.0 and 9.0 mm, with a rough surface, pink in color, with small black dots, painful on palpation. Conclusion dermatologist: plantar warts. Performed a biopsy of one of the warts, the histological conclusion: plantar wart. With the consent of the patient is made applique jeleniewo composition on the wart, in the dose of 0.2 ml After 10 minutes after application the surface of the warts acquired a yellowish-gray color, and 20 hours later there was a darkening and mummification. While there have been no systemic toxicity or side effects. After 35 days mummified scabs warts spontaneously separated from the underlying skin. On the location of the warts, within 28 days was observed areas of redness on the area corresponding to the area applications selenium composition. Subsequent observation of the patient after treatment did not reveal any pathological changes in the skin at the location of the wart or their recurrence.

Report No. 23

Patient D., born in 1986, has addressed in clinic of aesthetic medicine gcaron (Israel) against the presence of warts on hands. These warts appeared a few months ago, initially a single, then multiple. When viewed on the rear surface of the hands and forearms were determined three dozen flat PLO is different polygonal papules form size from 1.0 to 3.0 mm, with smooth surface, light brown, towering above the skin. Conclusion dermatologist: flat warts. Performed a biopsy of one of the large warts, the histological conclusion: flat wart. With the consent of the patient is made applique jeleniewo composition on the wart, in the dose of 0.2 ml in 15 minutes after application the surface of the warts acquired a yellowish-gray color. After 25 minutes, there was little swelling of the skin around the wart, and the next day there was a darkening and mummification. While there have been no systemic toxicity or side effects. 20 days later, mummified, full of sores, warts spontaneously separated from the underlying skin. On the location of the warts, within 40 days, was observed areas of redness on the area corresponding to the area applications selenium composition. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of the wart or their recurrence.

Report No. 24

The patient'clock born in 1991, went to the clinic of aesthetic medicine gcaron (Israel) against the appearance of the hands of small nodules. These deposits occurred several weeks before treatment, after playing with peers having the same nodules. When viewed on the rear surface CI the TEI hand and the inner surface of the forearm was determined up to a dozen translucent nodules, domed shape with a diameter of 1.0 to 4.0 mm, with a depression in the center, smooth, well defined. Conclusion dermatologist: molluscum contagiosum. Microscopic examination detachable Horny masses were detected intracellular cytoplasmic inclusions. The presence of molluscum contagiosum virus was confirmed using polymerase chain reaction. With the consent of the patient was performed applique jeleniewo composition of the nodules molluscum contagiosum, at a dose of 0.15 ml After 20 minutes after application the surface nodules acquired a yellowish-gray color. After 25 minutes, there was little swelling of the skin around knots, and 20 hours later there was a darkening and mummification. While there have been no systemic toxicity or side effects. After 25 days mummified scabs spontaneously separated from the underlying skin. On the location of the knots within 40 days, was observed areas of redness on the area corresponding to the area applications selenium composition. Subsequent monitoring of the patient after treatment did not reveal any pathological changes in the skin at the location of molluscum contagiosum or its recurrence.

Report No. 25

Patient R., born in 1932 went to the clinic of aesthetic medicine gcaron (Israel is b) a complaint to the appearance of the lesion redness and peeling of the skin on his left cheek. Disease duration of about 1 year. When viewed on the left cheek was defined area of the skin, with no very clear boundaries, 2.5 to×3.2 cm in size, covered with a dirty-brown horn masses, the destruction of which was revealed hyperemic slightly rough surface of the skin. Conclusion dermatologist: actinic (solar) keratosis. Performed a biopsy of the modified area of the skin, the histological conclusion: radiation keratosis, hyperplastic type. Considering the results of the histological examination and the patient, it was decided to hold local destruction affected by keratosis skin using jeleniewo composition. After obtaining the consent of the patient, made applique jeleniewo composition of the altered skin area, at a dose of 0.15 ml After 12 minutes after application, the surface has acquired a yellowish-gray color. After 25 minutes it appeared around minor swelling and strip hyperemia, and a day was observed darkening and mummification. While there have been no systemic toxicity or side effects. After 30 days mummified scabs have separated from the underlying skin. At the location of keratosis, within 50 days, was observed area of redness on the area corresponding to the area applications selenium composition. Subsequent monitoring of the patient during the periods which did not reveal any pathological changes in the skin at the location of keratosis.

Report No. 26

Patient F., born in 1938, has addressed in clinic of aesthetic medicine gcaron (Israel) against the presence of foci of altered skin on the palms of hands and soles of the feet. Disease duration was a few years, the number of lesions during this time has increased as well as their sizes. Professional responsibilities the patient previously a long time had contact with arsenic compounds. When viewed on the plantar surface of the feet and hands had multiple papules dirty grey colour with giperkineticescoy surface, with a diameter of from 0.5 to 4.0 mm, in the opinion of the dermatologist: ARSENICAL keratosis. Performed a biopsy of one of the papules, the histological conclusion: keratosis, with signs of moderate dysplasia. With the consent of the patient is made applique jeleniewo composition on papules, at a dose of 0.2 ml in 15 minutes after application the surface of the papules acquired a yellowish-gray color, and the next day there was a darkening and mummification. While there have been no systemic toxicity or side effects. After 45 days mummified scabs have separated from the underlying skin. At the location of papules, within 40 days, was observed areas of redness on the area corresponding to the area applications selenium composition. Subsequent observation of the patient after treatment did not reveal any who ecologicheskih skin changes at the location of papules or their recurrence.

Report No. 27

Patient A. born in 1948 went to the clinic of aesthetic medicine gcaron (Israel) 23.07.2001, against the presence of plaques on the mucous membrane of the left cheek. Disease duration was a few years. When viewed on the mucous membrane of the left cheek of 4.0 cm from the corner of his mouth, the line of contact of the teeth was determined by plaque grayish-white, slightly raised above the mucous membrane, irregular in shape, with a smooth surface, hard to the touch, the dimensions of 3.2×1.9 to see the Opinion of a dermatologist: leukoplakia of the oral cavity. 26.07.2001, performed a biopsy of the modified area of mucous membrane. The histological conclusion: oral leukoplakia. Considering the results of the histological examination and the patient, it was decided to hold the local destruction of the affected part of mucosa leukoplakia using selectabase of the drug. 15.08.2001, after obtaining the consent of the patient, made applique selectabase of the drug to the modified portion of the mucous in the dose of 0.1 ml 15 minutes after application mucous acquired a yellow color. After 25 minutes, appeared slight edema of the mucosa at the place of application, and a day was darkening and mummification. While there have been no systemic toxicity or side effects. After 25 days mummified scabs have separated from the underlying mucosa. For months the e location of leukoplakia, within 30 days, was observed area of redness on the area corresponding to the area applications selectabase drug. Subsequent observation of the patient during the period from October 2001 to November 2002 did not reveal any pathological changes in the mucous on the location of leukoplakia.

Report No. 28

Patient P. born in 1929 went to the clinic of aesthetic medicine gcaron (Israel) against the appearance of plaques on the skin of the left hand. Disease duration was more than eight years. When seen on the skin of the outer surface of the left forearm in the bottom third was determined by plaque with irregular outlines, raised above the skin, formed by the consolidation of reddish lenticular papules with a little peeling and clear boundaries, 4,8×4.2 cm in size. Located on the surface of plaques white flakes easily removed, with no signs of bleeding, exposing the red moist surface. Conclusion dermatologist: Bowen's disease. Performed a biopsy of the modified area of the skin, the histological conclusion: vnutriepetelialnaya squamous cell carcinoma (Bowen's disease). Considering the results of the histological study and desire of the patient, it was decided to undertake a local destruction of the tumour of the skin area using jeleniewo composition. After obtaining the consent of the patient, made applique Selene the first part on the modified area of the skin, dose of 0.2 ml. in 15 minutes after application the surface has acquired a yellowish-gray color. After 25 minutes, around it there was little swelling and strip hyperemia, and after the day was darkening and mummification. While there have been no systemic toxicity or side effects. After 30 days mummified scabs have separated from the underlying skin. On the location of the tumor, within 50 days, was observed area of redness on the area corresponding to the area applications selenium composition. Subsequent monitoring of the patient after treatment did not reveal any pathological changes of the skin on the location of the cancer or its recurrence.

Report No. 29

Patient Z. born in 1934 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of tumor on the left shoulder. The tumor appeared two years before treatment, gradually increasing in size. When viewed on the outer surface of the left shoulder in the bottom third was determined dome-shaped knot, red-pink, covered with crusts rounded shape with a diameter of 17 mm, thick consistency, sedentary, bleeding with minor trauma. Around education was defined area of skin peeling, partially covered with crusts. Conclusion dermatologist: infiltrating plocal the exact skin cancer. Performed a biopsy of the tumor, the histological conclusion: infiltrating squamous cell carcinoma of the skin. Considering the results of the histological study and desire of the patient, it was decided to hold the local destruction of the tumor using jeleniewo composition. After obtaining consent, made applique jeleniewo composition to the tumor at a dose of 0.2 ml in 15 minutes after application the surface of the tumor acquired a yellowish-gray color. After 25 minutes, there was little swelling of the skin and strip hyperemia around the tumor, and the next day was observed darkening and her mummification. While there have been no systemic toxicity or side effects. After 33 days mummified scabs tumor was separated from the underlying skin. On the location of the tumor, within 56 days, was observed in the area of hyperemia and retraction of the skin on the area corresponding to the area applications selenium composition. Subsequent monitoring of the patient after treatment did not reveal any pathological changes in the skin at the location of the tumor, metastasis, or recurrence.

Report No. 30

Patient S. born in 1939 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of nodules on the nose. Described the tumor appeared about one and a half years ago and slowly increased in size. When OSMO is re on the left wing of the nose closer to the tip had a waxy translucent nodule, solid to the touch, with a diameter of 4 mm, with a smooth surface, with translucent sanguineous capillaries. Conclusion dermatologist: basal cell cancer, nodular form. Performed the biopsy site, the histological conclusion: nodular basal cell cancer, I stage. Considering the results of the histological examination and the patient, it was decided to hold the local destruction of tumor using jeleniewo composition. After obtaining the consent of the patient is made applique jeleniewo composition to the tumor at a dose of 0.05 ml 15 minutes after application the surface of the tumor acquired a yellowish-gray color. After 25 minutes, there was little swelling of the skin and strip hyperemia around the tumor, and after 24 hours was observed darkening and mummification of the tumor. While there have been no systemic toxicity or side effects. After 45 days mummified scabs tumors spontaneously separated from the underlying skin. On the location of the tumor, in 52 days, was observed in the area of hyperemia, and then increased pigmentation, by area, the corresponding area of application. Subsequent observation of the patient after treatment did not reveal any pathological changes in the skin at the location of the tumor, metastasis, or recurrence.

Report No. 31

Patient K., born in 1937 obratilas the clinic of aesthetic medicine gcaron (Israel) against the presence of plaques on the skin of the back. Disease duration was a few years. When viewed at the level of the lower angle of the scapula, in the right paravertebral region, there was a plaque-like rounded lesion, pink color, with patches of peeling and koroobrazovaniya, diameter 2.7 cm, the edge of which consisted of small brilliant translucent nodules. Conclusion dermatologist: superficial basal cell cancer. Performed a biopsy of the tumor, the histological conclusion: superficial basal cell cancer. Considering the results of the histological study and desire of the patient, it was decided to undertake a local destruction of the tumour of the skin area using jeleniewo composition. After obtaining the consent of the patient, made applique jeleniewo composition to the tumor at a dose of 0.15 ml 15 minutes after application of the surface acquired a yellowish-gray color. After 25 minutes, around it there was little swelling and strip hyperemia, and after the day was darkening and mummification. While there have been no systemic toxicity or side effects. After 36 days mummified scabs have separated from the underlying skin. At the location of the tumor within 60 days, was observed area of redness on the area, the corresponding area of application. Subsequent monitoring of the patient after treatment does not detect the lo any pathological changes of the skin at the location of the tumor, metastasis or recurrence.

Report No. 32

Patient W. born in 1939 went to the clinic of aesthetic medicine gcaron (Israel) against the availability of education in the area of the right temple. Specified education appeared about two years ago, slowly increasing in size. When viewed in the right temporal region was determined ulcerative lesions of irregular shape, with uneven saped edges, uneven bottom, hot pink color, depth 1.5-2.0 mm, partially crusted dark brown color. The size of the lesion was 1.4×1.2 cm, around him there was a zone of hyperemia, width 2-3 mm. Conclusion dermatologist: with metatypical carcinoma skin cancer. Performed a biopsy of the tumor, the histological conclusion: with metatypical carcinoma skin cancer. Considering the results of the histological examination, it was decided to hold the local destruction of the tumor using jeleniewo composition. After obtaining the consent of the patient was performed applique jeleniewo composition to the tumor at a dose of 0.15 ml After 10 minutes after application the surface of the tumor acquired a yellowish-gray color. After 25 minutes, appeared moderate edema of the skin and increased redness around the tumor, and after 24 hours was darkening and mummification. While there have been no systemic toxicity or side effects. In the period from 38 to 41 days after the pplicatio was observed exfoliation mummified scabs tumor from the subject's skin. On the location of the tumor, within 50 days, was observed in the area of hyperemia of the skin with subsequent pigmentation area, the corresponding area of application. Observation of the patient after treatment did not reveal any pathological changes in the skin at the location of the tumor or its metastases in the surrounding areas of the skin, the nearby lymph nodes or metastases to distant organs and tissues.

Report No. 33

Patient S. born in 1986 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of nodules in the lower eyelids, neck, navel. Disease duration was more than a year. When inspecting the skin of the lower eyelids, anterior surface of the neck and around the navel there were multiple, symmetrical, dense, rounded nodules, skin color, diameter from 1.0 to 3.0 mm, slightly above the level of the skin. Conclusion dermatologist: syringoma, disseminated form. Performed a biopsy of one of the knots in the umbilical region, the histological conclusion: syringoma. Considering the results of the histological examination and the insistent request of the patient, it was decided to undertake a local destruction of the Fife with jeleniewo composition. After obtaining the consent of the patient, made applique jeleniewo composition on all available syringoma, at a dose of 0.2 ml in 15 minutes after application the surface coined syringoma acquired a yellowish-gray color. After 25 minutes around them appeared slight swelling of the skin, and after 20 hours was observed darkening and mummification areas, treated selenium composition. While there have been no systemic toxicity or side effects. After 35 days mummified scabs spontaneously separated from the underlying skin. On their location within 45 days was observed hyperemia, and then increased pigmentation of the skin, the area corresponding to the area applications selectabase drug. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of the Fife.

Report No. 34

Patient S. born in 1940 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of the node on the left cheek. Described the tumor appeared a few years ago, slowly increasing in size. When viewed on the left cheek there was towering over the skin site, firm to the touch, with a diameter of 9-10 mm, covered with constant skin. Conclusion dermatologist: adenoma sebaceous glands. Performed a biopsy of the tumor, the histological conclusion: adenoma sebaceous glands. Considering the results of the histological examination and the patient, it was decided to hold the local destruction of tumor using jeleniewo composition. After obtaining the consent of the patient is performed apply the tion jeleniewo composition to the tumor, at a dose of 0.15 ml After 10 minutes after application the surface of the skin over the tumor has acquired a yellowish-gray color. After 25 minutes, there was little swelling of the skin, and after 24 hours was observed darkening and mummification of the skin and underlying tumor. While there have been no systemic toxicity or side effects. After 45 days mummified scabs tumors spontaneously separated, and the location of the tumor, within 50 days, was observed in the area of hyperemia and retraction of the skin, and then it increased pigmentation, the area corresponding to the area applications selenium composition. Subsequent observation of the patient did not reveal any pathological changes in the skin at the location of the tumor, metastasis, or recurrence.

Report No. 35

The patient Century. born in 1976 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of pigment spots on the skin of the back. Spots appeared in the 12-14 years, gradually increasing in size. When seen on the skin of the back there were multiple spots of brown and dark brown, irregular in shape with jagged edges, rough surface, covered with thick dark hair, size from 3.0×4.0 mm to 8.0×15 mm Conclusion dermatologist: pigmented hairy epidermal nevus (nevus Becker). Performed a biopsy of one of the nevi histological conclusion: pigmented hairy epidermal nevus. Considering the results of the histological examination, it was decided to hold the local destruction of nevi with jeleniewo composition. After obtaining the consent of the patient, made applique jeleniewo composition on the mole, at a dose of 0.35 ml 15 minutes after application the surface nevi acquired a yellowish-gray color. After 25 minutes, appeared moderate edema of the skin and a thin strip of redness around nevi, and a day was observed darkening and mummification. While there have been no systemic toxicity or side effects. In the period from 35 to 45 days after application were observed exfoliation mummified scabs nevi from the underlying skin. At the location of nevi, within 65 days, was observed areas of hyperemia of the skin with subsequent pigmentation area, the corresponding area of application selenium composition. Observation of the patient after treatment did not reveal any pathological changes in the skin at the location of nevi.

Report No. 36

Patient X. born in 1958 turned in aesthetic medicine clinic gcaron (Israel) 06.11.2003, against the presence of plaques on the scalp. This plaque appeared in childhood, gradually increased in size. When seen on the skin of the occipital part of the head on the right was determined flat, soft, supple with blast the overall surface of the plaque, oval in shape, with dimensions of 1.8×2.7 mm, a height of 2,0-3,0 mm Conclusion dermatologist: nevus sebaceous glands (Elassona). 10.11.2003, performed a biopsy of the nevus. The histological conclusion: nevus seborrheic. Considering the results of the histological examination and the threat of malignant transformation, it was decided to hold the local destruction of the nevus with selectabase of the drug. 03.12.2003, after obtaining the consent of the patient, made applique selectabase drug nevus, at a dose of 0.15 ml 15 minutes after application the surface of the nevus has acquired a yellowish-gray color. After 25 minutes, there was little swelling of the skin and strip the redness around the nevus and the next day was observed darkening and mummification. While there have been no systemic toxicity or side effects. After 35 days mummified scabs nevus separated from the underlying skin. On the location of the nevus, within 45 days, was observed area of redness on the area corresponding to the area applications selectabase drug. Subsequent monitoring of the patient within two years after treatment did not reveal any pathological changes of the skin on the location of the nevus.

Report No. 37

Patient Z. born in 1967 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of tumor n is the skin of the scalp. The tumor appeared in adolescence, gradually increasing in size. When viewed in the temporal region of the scalp on the left was determined dense mobile pimple skin color, round shape, with a diameter of 1.6, see the Opinion of a dermatologist: trichoepithelioma. Performed a biopsy of the tumor, the histological conclusion: trichoepithelioma. Considering the results of the histological study and desire of the patient, it was decided to hold the local destruction of the tumor using jeleniewo composition. After obtaining consent, made applique jeleniewo composition to the tumor at a dose of 0.15 ml 15 minutes after application the surface of the tumor acquired a yellowish-gray color. After 25 minutes, there was little swelling of the skin and strip hyperemia around the tumor, and the next day was observed darkening and her mummification. While there have been no systemic toxicity or side effects. After 38 days mummified scabs tumor was separated from the underlying skin. On the location of the tumor, within 50 days, was observed in the area of hyperemia and small indrawing skin area, the corresponding area of application selenium composition. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of the tumor or its recurrence.

Report No. 38

Patient S. born in 1969 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of tumor on the left cheek. Described the tumor appeared a few years ago and slowly increased in size. When seen on the skin of the right cheek was determined dense dome-shaped movable node color normal skin, with a diameter of 1.1 cm, with extended sometimes on top of it and growing out of her hair. Conclusion dermatologist: Trifolium. Performed a biopsy of the tumor, the histological conclusion: well-differentiated tumor of the hair follicle (Trifolium). Considering the results of the histological study and desire of the patient, it was decided to hold the local destruction of tumor using jeleniewo composition. After obtaining the consent of the patient is made applique jeleniewo composition to the tumor at a dose of 0.15 ml 15 minutes after application the surface of the tumor acquired a yellowish-gray color. After 25 minutes, there was little swelling of the skin and strip hyperemia around the tumor, and after 24 hours was observed darkening and mummification of the tumor. While there have been no systemic toxicity or side effects. After 42 days mummified scabs tumors spontaneously separated from the underlying skin. On the location of the tumor, within 50 days, observed the camping area of hyperemia, and then increased pigmentation of the skin, the area corresponding to the area applications selenium composition. Subsequent monitoring of the patient showed no recurrence of the tumor.

Report No. 39

Patient T. born in 1937 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of pigmented site on the skin of the back. Described the tumor appeared a few years ago and slowly increased in size. When viewed in nadopasana the right pane was determined dense flat, with a rough surface site, almost black, with a diameter of 1.2, see the Opinion of a dermatologist: basal cell cancer, nodular form. Performed a biopsy of the tumor, the histological conclusion: pigmented basal cell cancer. Considering the results of the histological examination and the patient, it was decided to hold the local destruction of tumor using jeleniewo composition. After obtaining the consent of the patient is made applique jeleniewo composition to the tumor at a dose of 0.1 ml 15 minutes after application the surface of the tumor acquired a yellowish-gray color. After 25 minutes, there was little swelling of the skin and strip hyperemia around the tumor, and after 24 hours was observed darkening and mummification of the tumor. While there have been no systemic toxicity or side effects. After 42 days modif lirovannye scabs tumors spontaneously separated from the underlying skin. On the location of the tumor, within 50 days, was observed in the area of hyperemia, and then increased pigmentation, the area corresponding to the area applications selenium composition. Subsequent observation of the patient did not reveal any pathological changes in the skin at the location of the tumor, metastasis, or recurrence.

Report No. 40

Patient S. born in 1972 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of multiple nodules on the skin of the breast. These nodules appeared about ten years ago, gradually increasing in size. When viewed on the front surface of the chest there are multiple towering over the skin nodes, white in color, firm to the touch, with a diameter of from 2.0 to 8.0 mm Conclusion dermatologist: multiple epidermal cysts. Performed a biopsy of one of the cysts, the histological conclusion: the cyst funnel. Considering the results of the histological examination and the patient, it was decided to hold the local destruction of cysts using jeleniewo composition. After obtaining the consent of the patient is made applique jeleniewo composition on all existing epidermal cysts, dose of 0.25 ml 15 minutes after application the surface of the skin over the cyst acquired a yellowish-gray color. After 25 minutes, there was little swelling and the strip is hyperemia skin, and after 24 hours was observed darkening and mummification of the skin from the underlying tissue cysts. While there have been no systemic toxicity or side effects. After 35-45 days mummified scabs spontaneously separated, and the location of the cysts within 45-55 days, was observed areas of hyperemia and retraction of the skin, and then it increased pigmentation, the area corresponding to the area applications selenium composition. Subsequent observation of the patient after treatment did not reveal any pathological changes in the skin at the location of cysts or their recurrence.

Report No. 41

Patient O. born in 1987 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of red spots on the back of the neck. The specified spot was identified at birth. When viewed on the rear surface of the neck in the midline was determined spot red telangiectasias, irregular shape with sharp edges, size 6,0 x 8,0 see the Opinion of a dermatologist: hereditary telangiectasia (Unna nevus). Performed a biopsy of the spot, the histological conclusion: capillary malformation (congenital telangiectasia). Considering the results of the histological study and desire of the patient, it was decided to hold the local destruction of the stain with jeleniewo composition. After the floor is in the consent of the patient, made applique jeleniewo composition to an area of skin with telangiectasia, at a dose of 0.2 ml in 15 minutes after application the skin surface with teleangiectasia acquired a yellowish-gray color. After 25 minutes, there was little swelling of the skin and strip hyperemia around the spot, and the next day was observed darkening and mummification. While there have been no systemic toxicity or side effects. After 25-35 days mummified scabs spots were separated from the underlying skin. At the location of telangiectasia, within 45 days, was observed in the area of hyperemia, with subsequent increased pigmentation on the area corresponding to the area applications selenium composition. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of telangiectasia.

Report No. 42

The patient M born in 1983 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of a pink spot on his right cheek. The specified spot was detected at birth and increased in size as they Mature. When viewed on the right cheek there was a spot of irregular shape, bright pink color, with clear boundaries, disappearing when diascope, size 41×36 mm Conclusion dermatologist: nevus flaming (spot color of port wine). Given these clinically the who survey and the results of diascopy, it was decided to hold local destruction flaming nevus with jeleniewo composition. After obtaining the consent of the patient was performed applique jeleniewo composition to an area of skin with a nevus, in a dose of 0.1 ml 15 minutes after application the surface of the nevus has acquired a yellowish-gray color. After 20 minutes, appeared moderate edema of the skin and strip the redness around the nevus and the next day was observed darkening and mummification. While there have been no systemic toxicity or side effects. In the period from 32 to 36 days after application were observed exfoliation mummified scabs flaming nevus from the underlying skin. On the location of the spots, for 50 days, there has been an area of hyperemia of the skin with subsequent pigmentation area, the corresponding area of application selenium composition. Monitoring the patient did not reveal any pathological changes in the skin at the location of the flame nevus.

Report No. 43

Patient S. born in 1979 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of skin with a thin dilated vessels on the forehead. These skin changes were detected at birth and increased in area as it grows. When seen on the skin of the forehead close to the center there was a skin with diffuse network extended the vessels, endangered by diascopy, size 15×28 mm Conclusion dermatologist: nevus teleangiectasias. Clinical data and results of diascopy, it was decided to hold local destruction telangiectatica nevus with jeleniewo composition. After obtaining the consent of the patient, made applique jeleniewo composition on the skin area affected by nevus, in a dose of 0.1 ml 15 minutes after application the surface of the nevus has acquired a yellowish-gray color. After 25 minutes, appeared moderate edema of the skin and a thin strip of redness around the nevus and the next day was observed darkening and his mummification. While there have been no systemic toxicity or side effects. In the period from 32 to 40 days after application were observed exfoliation mummified scabs nevus from the underlying skin. On the location of the nevus, within 62 days, there has been an area of hyperemia of the skin with subsequent pigmentation area, the corresponding area of application. Subsequent observation of the patient did not reveal any pathological changes of the skin on the location of the nevus.

Report No. 44

Patient T. born in 1960 went to the clinic of aesthetic medicine gcaron (Israel) 24.05.2000, against the presence of stains dark purple color on the chest. Described spot appeared in early childhood and increasing the elk in size as it grows. When seen on the skin of the anterior surface of the chest, at the level of the 4th rib, near the outer edge of the sternum was determined node bluish-purple color, soft-elastic consistency with a clear border, with wrinkled surface, which was viewed as bundles of varicose veins, size of 1.8×2,5 see the Opinion of a dermatologist: venous malformation (blue bubble nevus). Given the clinical evidence and the patient's desire, it was decided to undertake a local destruction of the nevus with jeleniewo composition. After obtaining the consent of the patient is made applique jeleniewo composition on nevus, in a dose of 0.1 ml 15 minutes after application the surface of the nevus has acquired a yellowish-gray color. After 25 minutes, there was little swelling of the skin and strip the redness around the nevus, and after 24 hours was observed darkening and mummification. While there have been no systemic toxicity or side effects. After 40-45 days mummified scabs nevus spontaneously separated from the underlying skin. On the location of the tumor, within 50 days, was observed in the area of hyperemia and retraction of the skin, and then it increased pigmentation, by area, the corresponding area of application. Subsequent observation of the patient did not reveal any pathological changes of the skin on the location of the nevus.

EP the crisis No. 45

Patient N. 1963 born appealed to the clinic of aesthetic medicine gcaron (Israel) against the presence of nodules on the right thigh. The specified bundle was discovered at birth and slowly increased as growth. When viewed on the anteromedial surface of the right femur in the upper third was determined be accompanied vascular bundle, dark red, irregular configuration, easily bleeding, with a diameter of 5.0 mm, an opinion of a dermatologist: angiokeratoma limited. Performed the biopsy, the histological conclusion: angiokeratoma. Considering the results of the histological study and desire of the patient, it was decided to hold the local destruction of angiokeratoma using jeleniewo composition. After obtaining consent, made applique jeleniewo composition area angiokeratoma, at a dose of 0.05 ml 15 minutes after application the surface of the tumor acquired a yellowish-gray color. After 25 minutes, there was little swelling of the skin and strip hyperemia around angiokeratoma, and a day was observed darkening and her mummification. While there have been no systemic toxicity or side effects. Later 33-36 days mummified scabs tumor was separated from the underlying skin. The location angiokeratoma, within 55 days, there has been an area of hyperemia, and then the pigment is tion, by area, the corresponding area of application selenium composition. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of angiokeratoma.

Report No. 46

Patient S. born in 1976 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of the node on the right cheek. Describes the site appeared about six months ago, after a stab wound. When viewed on the right cheek had photoelasticity, dome-shaped papule bright red color, with shiny easy bleeding surface, with a diameter of 10 mm. Conclusion dermatologist: pyogenic granuloma. Performed a biopsy of the granuloma, the histological conclusion: pyogenic granuloma. Considering the results of the histological examination and the patient, it was decided to hold the local destruction of tumor using jeleniewo composition. After obtaining the consent of the patient is made applique jeleniewo composition of the granuloma in a dose of 0.1 ml 15 minutes after application the surface pyogenic granuloma acquired a yellowish-gray color. After 25 minutes, there was little swelling of the skin and strip the redness around granulomas, and after 24 hours was observed darkening and her mummification. While there have been no systemic toxicity or side effects. Later 40-43 days mummified scab is granuloma spontaneously separated, and the place of its location, within 50 days, was observed in the area of hyperemia of the skin, and then it increased pigmentation, the area corresponding to the area applications selenium composition. Subsequent observation of the patient after treatment did not reveal any pathological changes in the skin at the location of pyogenic granuloma.

Report No. 47

Patient S. born in 1950, has addressed in clinic of aesthetic medicine gcaron (Israel) against the presence of multiple nodules on the abdomen, which appeared a few years ago and gradually increasing in size. When seen on the skin of the anterior abdominal wall were six randomly located rounded dome-shaped nodules with a smooth consistency purple-red color, with a diameter of 2.0 to 4.0 mm, in the opinion of the dermatologist: senile angioma. Performed a biopsy of one of the nodules, the histological conclusion: capillary hemangioma. Considering the results of the histological examination and the patient, it was decided to hold the local destruction of knots using jeleniewo composition. After obtaining the consent of the patient, made applique jeleniewo composition of the nodules in a dose of 0.1 ml 15 minutes after application the surface angiomas acquired a yellowish-gray color. After 25 minutes, appeared moderate edema of the skin and strip the redness around angioma, and a day OBS who was darkening and mummification angiomas. While there have been no systemic toxicity or side effects. After 30-35 days mummified scabs angiomas separated from the underlying skin. On their location within 65 days, was observed areas of hyperemia of the skin area, the corresponding area of application selenium composition. Subsequent observation of the patient did not reveal any pathological changes in the skin at the location of angiomas.

Report No. 48,

Patient T. born in 1938 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of spots on the skin of the feet. These spots appeared about one year ago and slowly increased in size. When viewed on the rear surface of the stop symmetrically defined painless reddish-bluish spots of irregular shape, with a smooth surface, sharp edges, sizes from 0.9×1.2 cm to 3.6×3,8 see In the immediate vicinity of these spots were isolated hemorrhagic lesions in the form of achimota. Conclusion dermatologist: Kaposi's sarcoma, spotty stage. When examining the patient's blood for antibodies to HIV types 1 and 2 is not detected. 10.12.2000, performed a biopsy of the tumor. The histological conclusion: Kaposi's sarcoma, stage spots. Considering the results of the histological examination and the patient, it was decided to undertake a local destruction of the SDA is Oli using selectabase of the drug. 24.12.2000, after obtaining the consent of the patient is made applique selectabase of the drug to the tumor at a dose of 0.25 ml in 25 minutes after application the surface stains acquired a yellowish-gray color. After 35 minutes appeared slight swelling of the skin and strip hyperemia around the tumor, and after 24 hours was darkening and mummification. While there have been no systemic toxicity or side effects. Later 40-55 days mummified scabs tumors spontaneously separated from the underlying skin. On the location of the tumor, within 70 days, was observed in the area of hyperemia, and then increased pigmentation, the area corresponding to the area applications selectabase drug. Subsequent monitoring of the patient within five years after treatment did not reveal any pathological changes in the skin at the location of the tumor, metastasis, or recurrence.

Report No. 49

Patient O. born in 1989 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of bubbles on the skin of the neck and armpits. These bubbles were detected at birth and slowly increased in size. When viewed on the front surface of the neck, armpits were determined group of bubbles, located on the swollen, aggregated basis, with sizes from 3 to 5,5 mm When puncturing one of the bubbles separated lymph. Conclusion dermatologist: cystic lymphangioma. Considering the results of the histological study and the parents of the patient, it was decided to hold the local destruction of all existing lymphangioma using jeleniewo composition. After obtaining parental consent the patient made applique jeleniewo composition on lymphangioma, at a dose of 0.15 ml 15 minutes after application the surface lymphangioma acquired a yellowish-gray color. After 25 minutes, there was little swelling of the skin and strip the redness around lymphangioma, and after 24 hours there was a darkening and mummification. While there have been no systemic toxicity or side effects. Later 32-38 days mummified scabs of lymphangion spontaneously separated from the underlying skin. On their location within 52 days, was observed areas of hyperemia, and then hyperpigmentation of the skin, the area corresponding to the area applications. Subsequent monitoring of the patient after treatment revealed no recurrence of lymphangioma.

Report No. 50

Patient I., born in 1963 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of tumors in the neck, chest, armpits. Tumors appeared a few years ago and slowly increased in size. When is the show on the front of the neck, under the breast and armpits had more than a dozen tumors on a narrow stalk, round or oval, smooth consistency, bumpy skin pink color, with a diameter of from 1.0 to 7.0 mm, the Opinion of a dermatologist: multiple soft fibroma. Performed a biopsy of one of the tumor, the histological conclusion: cutaneous fibroma. Considering the results of the histological study and desire of the patient, it was decided to hold the local destruction of all existing tumors using jeleniewo composition. After obtaining the consent of the patient is made applique jeleniewo composition to all existing fibroids, in the dose of 0.2 ml in 15 minutes after application the surface of the tumors acquired a yellowish-gray color. After 25 minutes, there was little swelling of the skin and strip the redness around tumors, and after 24 hours there was a darkening and mummification. While there have been no systemic toxicity or side effects. After 21-28 days mummified scabs tumors spontaneously separated from the underlying skin. On the location of the tumor, within 30 days, we observed areas of hyperemia followed by hyperpigmentation, by area, the corresponding area of application selectabase drug. Observation of the patient after treatment revealed no recurrence of tumors.

Summary No. 51

Patient R., born in 1949 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of plaques on the upper eyelids. These plaques appeared a few years ago, gradually increasing in size. When seen on the skin of the upper eyelid, symmetrically, closer to the inner corners of the eyes had a slightly raised soft plaques yellow size 2.5×0,9 see the Opinion of a dermatologist: xanthelasma. Performed a biopsy of one of the plaques, the histological conclusion: xanthoma. Considering the results of the histological examination and the patient, it was decided to hold the local destruction of xanthelasma with jeleniewo composition. After obtaining the consent of the patient is made applique jeleniewo composition on the area of the plaques at a dose of 0.15 ml 15 minutes after application the surface of the plaques acquired a yellowish-gray color. After 25 minutes, appeared moderate edema of the skin and strip the redness around plaques, and the next day there was a darkening and mummification. While there have been no systemic toxicity or side effects. Later 30-38 days mummified xanthomas separated from the underlying skin. On their location, within 45 days, we observed areas of hyperemia of the skin, and then hyperpigmentation area, the corresponding area of application selenium composition. Subsequent observing the patient did not reveal any pathological changes in the skin at the location of xantom.

Report No. 52

Patient N. 1967 born appealed to the clinic of aesthetic medicine gcaron (Israel) against the presence of a nodule on the right cheek. The specified bundle has appeared for several years before turning and slowly increased in size. When viewed on the right cheek near the wing of the nose were determined dense dome-shaped papule, reddish in color, with a smooth surface with a diameter of 5.0 mm, an opinion of a dermatologist: fibrous papule. Performed a biopsy of the tumor, the histological conclusion: fibrous papule. Considering the results of the histological study and desire of the patient, it was decided to hold the local destruction of the fibrous papules with jeleniewo composition. After obtaining consent, made applique selectabase of the drug on the tumor at a dose of 0.05 ml 15 minutes after application the surface of the tumor acquired a yellowish-gray color. After 25 minutes, there was little swelling of the skin and strip the redness around the fibrous papules, and a day was darkening and mummification. While there have been no systemic toxicity or side effects. After 32 days mummified scabs tumors spontaneously separated from the underlying skin. On the location of angiofibroma, within 40 days, was observed in the area of hyperemia, and then hyperpigmentation, by area, according to stuudy area applications. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of the fibrous papules.

Report No. 53

Patient L., born in 1935 was referred to the clinic of aesthetic medicine gcaron (Israel) against the presence of tumor on the neck. The tumor appeared about a year ago and increased in size. When viewed on the rear surface of the neck was determined dense with fuzzy boundaries with a diameter of 1.4 cm node. The skin above it had a slightly pink color, with a little pitting on the top of the site. Conclusion dermatologist: Marcelina. Performed a biopsy of the tumor, the histological conclusion: primary cutaneous neuroendocrine carcinoma (tumor cells Merkel). Considering the results of the histological study and desire of the patient, it was decided to hold the local destruction of tumor using jeleniewo composition. After obtaining the consent of the patient is made applique jeleniewo composition to the tumor at a dose of 0.15 ml 15 minutes after application the surface of the tumor acquired a yellowish-gray color. After 25 minutes, there was little swelling of the skin and strip hyperemia around the tumor, and after 24 hours was observed darkening and mummification of the tumor. While there have been no systemic toxicity or side effects. Later 38-42 days mummified scabs is the tumor spontaneously separated from the underlying skin. On the location of the tumor, in 52 days, was observed in the area of hyperemia, and then increased pigmentation of the skin, the area corresponding to the area applications selenium composition. Subsequent monitoring of the patient after treatment revealed no metastasis of the cancer or its recurrence.

Report No. 54

Patient A. born in 1961, has addressed in clinic of aesthetic medicine gcaron (Israel) against the presence of multiple tumors on the body. These tumors appeared in adolescence, combined with multiple spots, which appeared in the first years of life, and lesions of the iris. When viewed on a body of the patient was determined many randomly located spots type "coffee with milk" and more than two dozen of tumors of soft consistency, covered unchanged skin, with a diameter of from 1.0 to 4.0, see When pressing the tumor was easily moved into the subcutaneous tissue, approximately one third of the tumor was on the leg. Consulted a dermatologist conclusion: neurofibromatosis, skin form. Given the clinical evidence and the patient's desire, it was decided to hold the local destruction of tumors using jeleniewo composition. By agreement with the patient is made applique jeleniewo composition in an existing tumor, the dose of 1.5 ml in 15 minutes after application the surface of the tumors acquired yellow is WATO-gray color. After 25 minutes, there was little swelling of the skin and strip the redness around tumors, and after 24 hours there was a darkening and mummification. While there have been no systemic toxicity or side effects. Later 29-37 days mummified scabs tumors spontaneously separated from the underlying skin. On their location within 55 days, was observed areas of hyperemia, and then hyperpigmentation area, the corresponding area of application. Subsequent observation of the patient did not reveal any pathological changes in the skin at the location of tumors or recurrence.

Report No. 55

Patient W. born in 1949 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of tumors in the neck in the axillary and inguinal areas. These tumors appeared a few years ago before turning and slowly increased in size. When viewed from the lateral surfaces of the neck, armpits and groin folds were more than a dozen round, soft, inelastic processes on the leg, compressed at the base, dark red color, with a diameter of from 1.0 to 5.0 mm, in the opinion of the dermatologist: multiple fibroepithelial polyps (acrochordon). Performed a biopsy of one of the tumor, the histological conclusion: fibroepithelial polyp. Considering the results of histology the definition of research and the desire of the patient, it was decided to hold the local destruction of all existing tumors using jeleniewo composition. After obtaining the consent of the patient is made applique jeleniewo composition on all available fibroepithelial polyps, in the dose of 0.2 ml in 15 minutes after application the surface of the tumors acquired a yellowish-gray color. After 25 minutes, there was little swelling of the skin and strip the redness around tumors, and after 24 hours there was a darkening and mummification. While there have been no systemic toxicity or side effects. Later 24-29 days mummified scabs tumors spontaneously separated from the underlying skin. On the location of tumors within 36 days, was observed areas of hyperemia followed by hyperpigmentation, by area, the corresponding area of application. Observation of the patient after treatment did not reveal any pathological changes in the skin at the location of tumors or recurrence.

Report No. 56

Patient S. born in 1939 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of nodules on the face, neck and neck. These nodules appeared several years before treatment, gradually increasing in size. When viewed on the face, back of the neck, on the back of the head there were more than a dozen besporjadok is located solitary papules red-brown color with umbilicate depression and hyperkeratosis in the center, diameter of 2.0 to 6.0 mm, in the opinion of the dermatologist: the warty dyskeratosis. Performed a biopsy of one of the nodules, the histological conclusion: the warty dyskeratosis. Considering the results of the histological examination and the patient, it was decided to hold the local destruction of knots using jeleniewo composition. After obtaining the consent of the patient, made applique jeleniewo composition of the nodules in a dose of 0.2 ml 15 minutes after application of the surface nodules acquired a yellowish-gray color. After 25 minutes around them appeared moderate edema of the skin and strip hyperemia, and after the day was darkening and mummification. While there have been no systemic toxicity or side effects. Later 32-36 days mummified scabs tumors were separated from the underlying skin. On their location, within 50 days, was observed areas of hyperemia of the skin area, the corresponding area of application. Subsequent observation of the patient did not reveal any pathological changes in the skin at the location of knots or their recurrence.

Report No. 57

Patient S. born in 1946 went to the clinic of aesthetic medicine gcaron (Israel) against the available sites on the forearms and shins. These nodes appear for several years before turning and slowly increased in time is erah. When viewed on the outer surface of the forearms and on the front surface of the legs were more than a dozen flat papules with a clearly defined border, slightly pigmented, located on aromatase basis, with a diameter of 0.2-0.8 cm, the Opinion of a dermatologist: multiple both anantomy. Performed a biopsy of one of the nodes, the histological conclusion: both of acanthoma. Considering the results of the histological study and desire of the patient, it was decided to undertake a local destruction of the sites with jeleniewo composition. After obtaining the consent of the patient is made applique jeleniewo composition on all available nodes in a dose of 0.25 ml 15 minutes after application of the surface nodes acquired a yellowish-gray color. After 25 minutes, there was little swelling of the skin and strip the redness around them, and after 24 hours was observed darkening and mummification. While there have been no systemic toxicity or side effects. After 30-40 days mummified scabs nodes spontaneously separated from the underlying skin. On their location within 35-50 days, was observed areas of hyperemia, and then increased pigmentation of the skin, the area corresponding to the area applications. Subsequent monitoring of the patient after treatment did not reveal any pathological changes is s skin at the location of nodes or their recurrence.

Report No. 58

Patient K., born in 1956 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of the site on the skin of the right shoulder. Disease duration was a few years. When viewed on the outer surface of the right shoulder in the middle third had a solitary papule purple color, with a grid of Wickham, with a diameter of 0.9, see the Opinion of a dermatologist: benign elsewedy keratosis. Performed the biopsy site, the histological conclusion confirmed the opinion of a dermatologist: benign elsewedy keratosis. Considering the results of the histological study and desire of the patient, it was decided to undertake a local destruction of the site by using jeleniewo composition. After obtaining the consent of the patient, made applique jeleniewo stock on site at a dose of 0.15 ml 15 minutes after application, the surface has acquired a yellowish-gray color. After 25 minutes, around it there was little swelling and strip hyperemia, and a day was observed darkening and mummification. While there have been no systemic toxicity or side effects. 28 days later mummified scabs have separated from the underlying skin. On the location of the site within 50 days, was observed area of redness on the area, the corresponding area of application. Subsequent monitoring patients the th after treatment did not reveal any pathological changes in the skin at the location of the site or its recurrence.

Report No. 59

The patient P. born in 1946 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of warty nodes on the right hand. These sites appeared a few years ago, their appearance was preceded by the formation of gray easily dissociating small nodules. The patient worked for many years in the refinery. When viewed on the rear surface of the right hand and forearm had multiple papules, with a warty surface, pale-grayish color, with a diameter of 3-5 mm Conclusion dermatologist: tar keratosis. Performed a biopsy of one of the papules, the histological conclusion: tar keratosis. Considering the results of the histological examination and the patient, it was decided to hold local destruction papules with jeleniewo composition. After obtaining the consent of the patient is made applique jeleniewo composition on all available papules, at a dose of 0.2 ml in 15 minutes after application the surface of the papules acquired a yellowish-gray color. After 25 minutes, there was little swelling of the skin around papules, and after 24 hours there was a darkening and mummification. While there have been no systemic toxicity or side effects. After 20-28 days mummified scabs papules spontaneously separated, and the place of their location, within 30 days, watched the camping sites hyperemia followed by hyperpigmentation, by area, the corresponding area of application. Further observation of the patient after treatment did not reveal any pathological changes in the skin at the location of papules or their recurrence.

Report No. 60

Patient S. born in 1929 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of tumor on the neck. Described the tumor appeared about one and a half years ago and slowly increased in size. When viewed in the supraclavicular region at the base of the neck to the left was determined mushroom knot with warty surface, thick consistency, on a broad basis, easily bleeding with minimal trauma, brown-red color, a size of 1.6×1,5×1,2 see the Opinion of a dermatologist: warty squamous cell carcinoma. Performed a biopsy of the tumor, the histological conclusion: warty squamous cell carcinoma, stage I. Considering the results of the histological study and desire of the patient, it was decided to hold the local destruction of tumor using jeleniewo composition. After obtaining the consent of the patient is made applique jeleniewo composition to the tumor at a dose of 0.25 ml 15 minutes after application the surface of the tumor acquired a yellowish-gray color. After 25 minutes, there was little swelling of the skin and strip hyperemia around the tumor, and after 24 hours were observed her sweat is opinion and mummification. While there have been no systemic toxicity or side effects. Later 24-28 days mummified scabs tumors spontaneously separated from the underlying skin. On the location of the tumor, within 50 days, was observed in the area of hyperemia and retraction of the skin, and then hyperpigmentation, by area, the corresponding area of application. Subsequent monitoring of the patient after treatment revealed no recurrence of the tumor or its metastases.

Summary No. 61

Patient K., born in 1953 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of a lump on the eyelid of the left eye. The specified bundle appeared about a year ago and slowly increased in size. When viewed along the edge of the upper eyelid at the inner corner of the left eye was determined by a firm, round, painless nodule whitish color with a diameter of 4.0 mm, an opinion of a dermatologist: sabiana carcinoma. Performed a biopsy of the nodule, the histological conclusion: sabiana carcinoma. Considering the results of the histological study and desire of the patient, it was decided to undertake a local destruction of the bundle using jeleniewo composition. After obtaining the consent of the patient is made applique selectabase drug knot, the dose of 0.05 ml 15 minutes after application, the surface has acquired a yellowish-grey okra is ku. After 25 minutes, there was little swelling of the skin and strip hyperemia around the knot, and after 24 hours was observed darkening and mummification. While there have been no systemic toxicity or side effects. After 32 days mummified scabs nodules spontaneously separated from the underlying skin. On the location of the nodule, within 35 days, was observed in the area of hyperemia followed by hyperpigmentation, by area, the corresponding area of application. Observation of the patient after treatment revealed no recurrence of nodules or its metastases.

Report No. 62

The patient Was born in 1972 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of multiple nodes on the head, neck and mouth. These nodules appeared more than half a year ago and gradually increased in size. When viewed on the scalp, around the ears, on the side of the neck to the left and the mucosa of the left cheek had multiple randomly located pulsating nodes of soft consistence, red, diameter ranging from 3.0 mm to 10.0 mm Conclusion dermatologist: angiolymphoid hyperplasia with eosinophilia (epithelioma hemangioma). Performed a biopsy of one of the nodes, the histological conclusion: angiolymphoid hyperplasia with eosinophilia. Given the clinical data and the results of histological examination, it was decided to hold the local destruction of hemangiomas with jeleniewo composition. After obtaining the consent of the patient, made applique jeleniewo composition on all available hemangioma, at a dose of 0.4 ml 15 minutes after application the surface epitheliomas hemangioma acquired a yellowish-gray color. After 25 minutes, appeared moderate edema of the skin and a thin strip of redness around hemangiomas, and the next day there was a darkening and mummification. While there have been no systemic toxicity or side effects. In the period from 27th to 36th day after application was observed exfoliation mummified scabs hemangiomas from the underlying skin. On their location within 43 days, was observed areas of hyperemia of the skin with subsequent pigmentation area, the corresponding area of application. Observation of the patient after treatment did not reveal any pathological changes in the skin at the location of epitheliomas hemangioma.

Report No. 63

Patient O. born in 1978 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of the node on the left leg. The specified node appeared about a year ago, presumably after injury and slowly increased in size. When viewed on the outer surface of the left tibia in the middle third were determined dense intradermal is round the site with blurred boundaries and edges, merging with normal skin, slightly above its level, blue-black, with a diameter of 1.6, see the Opinion of a dermatologist: benign fibrous histiocytoma (dermatofibroma). Performed the biopsy site, the histological conclusion: benign fibrous histiocytoma. Considering the results of the histological study and desire of the patient, it was decided to hold the local destruction of dermatofibroma using jeleniewo composition. After obtaining consent, made applique jeleniewo composition to the area of the node, in a dose of 0.1 ml 15 minutes after application the surface of the site has acquired a yellowish-gray color. After 25 minutes it appeared around a slight swelling of the skin and strip hyperemia, and a day was observed darkening and mummification. While there have been no systemic toxicity or side effects. After 29 days mummified scabs site was separated from the underlying skin. On the place of its location, within 46 days, there has been an area of hyperemia, and then hyperpigmentation, by area, the corresponding area of application. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of dermatofibroma.

Report No. 64

Patient S. born in 1928 went to the clinic of aesthetic medicine gcaron (Israel) with shaking the fight on the presence of fast-growing site on the skin of the neck. The specified node appeared three months before treatment and quickly increased in size. When viewed on the side of the neck to the right was determined dense node with a smooth surface, red color, with a diameter of 1.6, see the Opinion of a dermatologist: the atypical fibroxanthoma. Performed the biopsy site, the histological conclusion: atypical, fibroxanthoma. Considering the results of the histological examination and the patient, it was decided to undertake a local destruction of the site by using jeleniewo composition. After obtaining the consent of the patient is made applique jeleniewo composition to the tumor at a dose of 0.15 ml 15 minutes after application the surface of the site has acquired a yellowish-gray color. After 25 minutes, there was little swelling of the skin and strip the redness around the site, and after 24 hours was observed darkening and mummification site. While there have been no systemic toxicity or side effects. After 32 days mummified scabs node spontaneously separated from the underlying skin. On the location of the node within 46 days, there has been an area of hyperemia, and then increased pigmentation, the area corresponding to the area applications. Subsequent observation of the patient after treatment did not reveal any pathological changes in the skin at the location of node metastases or recurrence.

Report No. 65

Patient E. born in 1935 was referred to the clinic of aesthetic medicine gcaron (Israel) against the presence of the site on the scalp. The specified node has appeared for several years before turning and slowly increased in size. When seen on the skin of the parietal region of the head there were dense solitary node, raised above the level of the skin, ulceration in the center, with a diameter of 1.9, see the Opinion of a dermatologist: hair growth. Performed the biopsy site, the histological conclusion: hair tumor (proliferating trichilemmal cyst). Considering the results of the histological study and desire of the patient, it was decided to hold the local destruction of tumor using jeleniewo composition. After obtaining the consent of the patient is made applique jeleniewo composition to the tumor at a dose of 0.25 ml 15 minutes after application the surface of the tumor acquired a yellowish-gray color. After 25 minutes around her appeared a slight swelling of the skin and strip hyperemia, and after 24 hours was darkening and mummification. While there have been no systemic toxicity or side effects. After 33 days mummified scabs tumors spontaneously separated from the underlying skin. On the location of the tumor, within 40 days, was observed in the area of hyperemia, and then increased pigmentation to the LM, area corresponding to the area of application. Subsequent monitoring of the patient after treatment did not reveal any pathological changes in the skin at the location of the hair of the cancer or its recurrence.

Report No. 66

Patient R., born in 1983 went to the clinic of aesthetic medicine gcaron (Israel) against the presence of nodes on the buttocks and thighs. These nodes were detected at birth and slowly increased in size as it grows. When viewed on the buttocks and posterior thighs randomly determined over a dozen domed nodes, soft texture, covered with smooth, flesh-colored skin, with a diameter of from 5.0 to 15.0 mm. Conclusion dermatologist: lipomatosis nevi. Performed a biopsy of one of the nodes, the histological conclusion: adipose tissue. Considering the results of the histological study and desire of the patient, it was decided to hold the local destruction of all existing lipomatosis nevi using jeleniewo composition. After obtaining the consent of the patient is made applique jeleniewo composition on all existing nevi, at a dose of 0.4 ml 15 minutes after application of the surface nodes acquired a yellowish-gray color. After 25 minutes, there was little swelling of the skin and strip the redness around sites, and within 24 hours there was a darkening and mummification. P and that there have been no systemic toxicity or side effects. Later 29-35 days mummified scabs nevi spontaneously separated from the underlying skin. On their location, within 45 days, we observed areas of hyperemia with indrawing of the skin and subsequent hyperpigmentation, the area corresponding to the area of application. Observation of the patient after treatment revealed no recurrence lipomatosis nevi.

Report No. 67

Patient I., born in 1952 went to the clinic of aesthetic medicine gcaron (Israel) with a complaint against the increased formation of wrinkles on the skin on the face. Fine surface wrinkles appeared the patient a few years ago, attempts to eliminate them with the help of cosmetics did not succeed. When viewed on facial skin in the cheeks, around the eyes, nasolabial folds, forehead was determined mesh fine superficial wrinkles, giving the skin flabby appearance. Conclusion dermatologist: wrinkles of the skin. Given the clinical data and the desire of the patient, it was decided to undertake a thorough exfoliation of the skin using jeleniewo composition. After obtaining the consent of the patient using the swab was performed applying a 10% aqueous solution selectabase of the drug to the skin with excessive wrinkling at the dose of 1.5 ml of 20 minutes after application the surface of the skin has become pale yellow in color, and after 24 hours was observed surface Modific the tion of the epidermis. While there have been no systemic toxicity or side effects. After 9-10 days mummified scabs epidermis spontaneously separated from the underlying skin. Then within 10 days celebrated its easy hyperemia. In the end, after three weeks after application there was a significant decrease in the number of small wrinkles on the face, and in some areas (cheeks) was almost complete disappearance. Further observation of the patient after peeling did not reveal any pathological changes on her skin.

Report No. 68

Patient D. (1975), applied to RCRC and PS (Moscow) with complaints about the presence of itchy red weeping spots between the toes, destruction and detachment of the nail on the I's and II's toes. Disease duration: candidiasis of the skin of the feet. When viewed in the interdigital spaces I-II, II-III, III-IV fingers of both legs had exudative pale pink spots with a touch, the nails on the I's and II's toes eaten and debonded in the distal, subungual Lodge had a yellowish color. Microscopic examination of scrapings from the affected areas of the skin found Druze fungus. Conclusion dermatologist: candidiasis of the skin of the feet with subungual lesion. After obtaining the consent of the patient, without anesthesia, performed applique selenium composition to the affected Uch the tough skin, in the dose of 0.2 ml After 12-15 minutes, the treated skin was yellow, around them there was a small swelling and hyperemia, and after 20-24 hours they darkened and mummified. 10-14 days after treatment mummified areas freely separated from the skin, and in their place for 24-28 days remained areas of hyperemia. Subsequent observation of the patient showed no recurrence of candidiasis.

0.11
No.Acid, its structural formula and mol. weightRXYMThe amount of acid RCXY(CH2)m-COOHThe number of SeO2mV=110.98TemperatureThe reaction timeThe ratio of acid:selenium dioxideThe concentration of acid
gg-molgg-mol °Cminmoth%
12-chloro-propionic CH3lC 108.52CH3NCL065.10.60.660.00690150100:195,0
2The sameCH3NCL065.10.62.660.0249012025:198,0
3The sameCH3NCL065.10.66.660.0685 9010:170,0
4The sameCH3NCL065.10.616.60.1580604:150,0
5The sameCH3NCL065.10.622.20.2751803:145,0
6The sameCH3NCL065.10.633.30.3852102:1 25,0
72-bromo-propionic CH3Snogson 152.92CH3NVG015.30.10.110.00170240100:145,0
82-fluoro-propionic CH3F 92.07CH3NF018.40.20.110.00150120200:150,0
92-chloro-2-bromo-propionic CH3rl 187.42CH3CLVG037.50.20.220.00260 90100:145,0
10Pendaftar-propionic CF3CF2COOH 164.0CF3FF032.80.20.220.0025040100:150,0
112-chloro-oil CH3CH2l 122.52With2H5NCL124.50.20.220.00275120100:165,0
122-chloro-valeric CH3(CH2)2l 136.52With3H7NCL227.30.20.00190100200:150,0
132-chloro-nylon CH3(CH2)3l 150.52With4H9NCL345.10.30.110.00118060300:190,0
142-chloro-Caprylic CH3(CH2)4l 164.52C5H11NCL432.90.20.110.00120030200:190,0
15Fenilalanina C6H5CHClCOOH 170.45With6H5N CL017.00.10.110.00121530100:195,0

1. The product in the form of a solution for the treatment of benign, viral, pre-malignant and malignant nematoctonus skin lesions, dysplastic lesions visible mucous membranes, fungal diseases of the skin, wrinkles and age spots, representing a compound of General formula
H2S3·x·[R-CFS-(CH2)m-COOH], where x=2-6,
obtained by the interaction dboxii selenium with haloalkaline
acids of General formula
R-CXY-(CH2)m-COOH,
where R = phenyl, alkyl General formula CnH2n+1;
n=1-5, X=N or Y, Y=F, Cl, Br or J, m=0-10.

2. A method of obtaining a product according to claim 1, characterized in that malodorous acid or its aqueous solution was added selenium dioxide, stirred at a temperature of 20-215°C for 5-480 min and then filtered off from the precipitate.

3. The method according to claim 2, characterized in that the concentration of the aqueous solution haloalkaliphilic acids used in the synthesis of the product according to claim 1, is in the range 1-98 wt.%.

4. Product in the form of races the thief for the treatment of benign, viral, pre-malignant and malignant nematoctonus skin lesions, dysplastic lesions visible mucous membranes, fungal diseases of the skin, wrinkles and age spots, containing 0.1-50 wt.% the product according to claim 1, 1-99 wt.% haloalkaliphilic acids and the rest is water.

5. A method of treating benign, viral, pre-malignant and malignant nematoctonus skin lesions, dysplastic lesions visible mucous membranes, fungal diseases of the skin, wrinkles and age spots, comprising topical application of the product according to claim 1 in the form of applications.

6. The method according to claim 5, characterized in that the product is used in the form of ointments, solution, cream, paste or gel.



 

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