Wound-healing remedy

FIELD: medicine, cosmetology.

SUBSTANCE: the suggested wound-healing remedy includes a gel-forming agent, an active substance and distilled (deionized) water. As the active substance it contains Mexidol (2-ethyl 6-methyl 3-oxypyrridine succinate) at the following ratio of components, weight%: gel-forming agent 0.5-5.0, stabilizing agent 0.01-0.8, conservant 0.01-1.0, Mexidol 0.01-10.0, distilled (deionized) water - the rest. The suggested remedy is highly efficient. It is of pronounced wound-healing action in 1, 2 and 3 phases of wound process. It quickly liquidates inflammatory processes, decreases painfulness, edema, considerably improves the state of affected tissues, accelerates reparative-degenerative processes and terms of epithelization. It possesses the wide spectrum of action, manifests pronounced action at treating different skin and mucosal lesions - wounds, fissures, bedsores, trophic ulcers of different genesis, surface burns of 1-3 degree, radiation lesions, it, also, removes skin microlesions that possess the nature of cosmetic defects, moreover, it improves skin structure.

EFFECT: higher efficiency of application.

2 ex

 

The invention relates to medicine and cosmetology, namely to medicines, made in the form of a gel for local application - treatment of skin lesions and mucous, trophic ulcers, wounds, burns, injury of the skin is complicated by purulent-inflammatory processes.

There are a large number of wound healing medicines for local use, made in the form of various dosage forms, ointments, emulsions, applications, gels.

Known ointments used in the first phase of wound healing containing substances with antimicrobial action, for example syntomycin, tetracycline, gentamicina and others:

- Kotelnikov VP Wounds and their treatment. - M. Knowledge. 1991. - 123 C.;

- Kuzin M.I. Wounds and wound infection. - M. Medicine, 1990. - 484 S.;

- Lyapunov N.A., Kalinichenko NF New opportunities for local treatment of wounds complicated anaerobic infection. // Implementation of scientific achievements in practical pharmacy: proc. Dokl. Rep. The scientific. Proc. October 16-18, 1991 - Kharkov, 1991 - 38 C.

The disadvantage of these ointments is the unidirectionality of their action - antimicrobial. They have limitations because of their individual intolerances, as well as the risk of development of side effects with long - term use to reduce the sensitivity of microflora, disorders of the internal is of lanov.

Complex influence on the wound surface multicomponent have ointment on osmotically active basis "Levomicol", "Sulfamyl", "Levein" (Mashkovsky PPM Medicines: a Manual for physicians: 2 T. M.: Medicine, 1995, - 575 S.).

However, these ointments also contain antibacterial and sulfanilamide drugs and have side effects.

It is known for the treatment of various skin lesions and mucous "Solcoseryl"containing standardized deproteinizing hemodialysate from the blood of calves produced in the form of ointment, cream and gel (Reference Vidal, drugs in Russia, Astra Pharm Service, 1997, 531 S.).

"Solcoseryl" improves metabolism, accelerates regeneration of damaged cells and tissues.

The disadvantage of the drug is its low efficiency. "Solcoseryl" on the gel and ointment basis recommended for integrated use with the appearance of fresh granulation on the surface of wounds, ulcers, burns the surface. This requires long-term treatment and compliance with recommendations, which often disturbed patients and does not lead to proper results.

As the closest analogue taken a wound healing agent "Vitamaster-gel" (EN 2185149, CL IPC a 61 K 9/06; 31/715; 35/56, a 61 P 29/00, 2002), containing gelling, mummy cleaned and distilled water in the following ratio of components, wt.%:

Gelling1.0-3.0
Shilajit is cleared1.0-5.0
Distilled waterrest

As a gelling in some cases can be selected from polysaccharides, at least galactomannan or glucomannan or hyaluronic acid. In other cases, as the gel can be selected gelatin or pectin, or Aerosil, or zeolites.

The disadvantages of the above, the gel composition can be attributed to the fact that Shilajit, as a drug, clinically strictly not been studied. It is considered that it is of animal origin. However, all of the components included in it, up to the present time is not defined. Therefore, the application of ointment and gel compositions with Shilajit can cause in patients with allergic reactions. As a result, the gel can be used only in a limited contingent of patients in the treatment of skin lesions and mucous various origins. Treatment of patients with the use of this gel requires an individual approach.

The objective of the invention is to provide a highly effective wound healing agent, with a more pronounced clinical effect with more functionality.

Things the ity of the invention is what a wound healing agent, comprising gelling, the active substance and distilled water, as the active substance contains Mexidol (2-ethyl 6-methyl-3-oksipiridina succinate) in the following ratio, wt.%:

Gelling0.5-5.0
Stabilizer0.01-0.8
Preservative0.01-1.0
Mexidol0.01-10.0

Distilled (deionized) water - the rest.

The use of the invention allows to obtain the following technical result.

We offer wound healing is highly effective. It has a strong healing effect 1, 2 and 3 phases of wound healing.

Quickly eliminate inflammation. 2-3 days of its application marked reduction of pain, edema, significantly improves the condition of damaged tissues, accelerated repair-degenerative processes, significantly accelerated epithelization time.

It has a wide range of actions and functionality, shows a pronounced therapeutic effect in the treatment of various skin lesions and mucous membranes, wounds, fractures, pressure ulcers, venous ulcers of various origins, surface is x burns 1-3 degrees, radiation injuries, eliminates pinholes skin, cosmetic defects, improves skin texture and can be used in medicine and cosmetology.

This gel has no contraindications, harmless, do not cause allergic reactions has no contraindications and age restrictions. Does not require additional use of other drugs, including antimicrobial drugs and other

The technical result is achieved due to the introduction of the gel drugs Mexidol, synergies and prolonged action of its components.

High therapeutic effect of the gel is primarily due to the wide range of his actions and pathogenetically focus on all stages of the wound healing process.

Mexidol has anti-inflammatory, antibacterial, anti-inflammatory, adaptogenic, antihypoxic, anti-toxic effect, improves microcirculation, reparative-regenerative processes, improves local immunity that allows you to simultaneously affect all links in the pathogenesis of wound healing.

The restoration of the microcirculation occurs due to the stabilization of the cell membrane permeability of the capillary walls maintain their elasticity, normalize them in metabolic processes. Mexidol inhibits the intensity of the freedoms radikalnogo oxidation of lipids, thereby increasing its direct action on the respiratory chain by increasing adenosine triphosphate (antihypoxic effect), which leads to improved oxygen supply to tissues. The change of membrane fluidity capillaries helps to reduce blood viscosity due to the normalization of the ratio of atherogenic and antiatherogenic functions of lipoproteins, to improve the rheological properties of blood, improve blood circulation, thereby stimulating the processes of regeneration and repair.

Antitoxic effect of Mexidol is achieved by reducing toxic levels of free radicals, sorption effects on the primary source of inflammatory endotoxemia (binding endo - and exotoxins), which is enhanced by the presence of the sorption properties of the gelling base. While increasing the drainage function of the lymphatic system. The gel thus promotes rapid removal of toxins from the hearth to the stabilization of cell membranes and blood vessels, which provides the active substance, it prevents the penetration of pathogenic microorganisms, toxins and degradation products in the blood.

Mexidol, having membranostabiliziruyuschim properties, stimulates detoxification processes, to normalize the microflora, which leads to normalization of metabolism of damaged cells and danestone energy processes, he also contributes to a significant improvement of treatment results.

Encouraging links nespetsificheskoi humoral protection, boosting local immunity at the expense of the phagocytic activity of leukocytes, Mexidol leads to rapid elimination of the inflammatory process in the damaged tissues.

High therapeutic activity of the gel due to the presence of Mexidol, as a powerful antioxidant, while immunomodulatory and immunostimulant properties.

Given that Mexidol chemically active substance, the authors conducted research on the choice of a compatible basis, because it leads to the destruction of the most used in the Russian and foreign pharmaceutical industry, gel and ointment bases.

The basis of the following demands were met:

- the possibility of application in the pharmaceutical industry.

- compatible with Mexidol

- suitable for application to the mucous membrane

- do not create a barrier to the gradual penetration of the main active substances deep into the tissues.

As a result of tests it was determined that the basis - gelling substance of a series of cellulose ethers or gel-forming substance on the basis of polyvinylpyrolidone (PVP), or gel-forming substance on the basis of resins that meet the requirements for IP is of use them as protection for medicines in the pharmaceutical industry in accordance with the regulatory organizations of different countries.

Mexidol in the proposed ratio optimally interacts with the gelling base, giving it its properties, because it is neutral. This Foundation provides active diffusion and deep penetration of Mexidol in the damaged tissue, its gradual release and prolonged action, thus enabling you to get quick and pronounced therapeutic effect. While on the surface of the wound is formed almost monomolecular film having high gas permeability while at the same time strong biocidal and reparative effects on the fabric.

As the gel-forming bases (gel) using a hydroxyethyl cellulose or sodium carboxymethyl cellulose or hydroxypropylcellulose:

- hydroxyethylcellulose pharmaceutical purposes (SCE) is a non-ionic cellulose ether, quickly dissolved in water. In solution this product acts as a thickener and controlling the rheology agent, a protective colloid, binder, stabilizer and auxiliary agent for dispersion (analog is NATROSOL 250 Pharm).

the sodium carboxymethyl cellulose (CMC). Analog is BLANOSE Cellulose Gum. Meets the requirements of the European Pharmacopoeia and United States Pharmacopeia.

- hydroxypropylcellulose (GOC). Similar "KLUCEL Pharm. Combines thermo is elasticnet and surface activity, and stabilizing properties.

As preservative choose is compatible with Mexidol and well-established sodium salts of parabens, meeting the requirements of the Pharmacopoeia, methylparaben, propylparaben and the like). Perhaps the usage of other preservatives such as propylene glycol, etc.

As a stabilizer can be used used in the pharmaceutical industry sodium salt of ethylenediaminetetraacetic acid analog is TRILON-B or other, similar properties and actions. As active substances are used Mexidol® (2-ethyl 6-methyl-3-oksipiridina succinate).

A wound healing agent is prepared as follows.

Prepare all the necessary components: gel-forming base, a stabilizer, a preservative, an active substance - Mexidol and distilled water in the prescription number.

In a special reactor placed the required amount of deionized distilled water, heat it up to 70°and with constant stirring injected gel-forming base and stabilizer.

Next, in a separate container dissolve under stirring at room temperature preservative, then add Mexidol and stirred until complete transparency of the solution. The resulting solutions are mixed while stirring for two hours to full the th transparency and homogeneity of the system.

The obtained gel is cooled to room temperature. Measure the viscosity and pH. Viscosity pH should be 5.0-7.0.

Ready gel Packed in metal or plastic tubes.

Example 1. The content of the components of therapeutic composition, wt.%:

The sodium carboxymethyl cellulose1.0
Nitromethylene0.01
Trilon B0.01
Mexidol0.1
Deionized waterrest

First dissolve under stirring at room temperature methylparaben to full transparency of the solution (about 15 min). Then at room temperature dissolve Mexidol® and stirred until complete transparency of the solution. Next, in a separate container heat the water to 40°and dissolved Trilon B under stirring until complete transparency R-RA, then the resulting solution was heated to 70°and with vigorous stirring asleep carboxymethylcellulose and stirred for two hours to full transparency and homogeneity of the system. Add to the solution previously obtained solution and stir for 10 minutes. The prepared gel is cooled to room temperature. Next measure the viscosity and pH of the gel. pH GE is I =5.0-7.0.

Example 2. The content of the components of therapeutic composition, wt.%:

The sodium carboxymethyl cellulose5.0
Nitropropiophenone1.0
Trilon B0.8
Mexidol10.0
Deionized waterrest

First dissolve under stirring at room temperature methylparaben to full transparency of the solution (about 15 min). Then at room temperature dissolve Mexidol® and stirred until complete transparency of the solution. Later in another capacity heat the water to 40°and dissolved Trilon B under stirring until complete transparency R-RA, then the resulting solution was heated to 70°and with vigorous stirring asleep carboxymethylcellulose and stirred for two hours to full transparency and homogeneity of the system. Add to the solution previously obtained solution and stir for 10 minutes. The prepared gel is cooled to room temperature. Next measure the viscosity and pH of the gel. the pH of the gel = 5.0-7.0.

The composition is a homogeneous plastic mass, withstands term storage without changing microbiological, physico-chemical properties of not less than 2 years.

Provedeniyavirtualnyh test wound healing agent.

In order to identify the effect of the gel on the epithelial tissue was used in the mouse experiment. The wound inflicted by the scalpel on the shaved skin of the mouse. The depth of the wound was about 0.8 mm, the length of the wound 3 mm in the first day after application of the gel began to form a scab, on the third day, the wound edges are fully met, the skin has regained its elasticity on day 7.

To study the activity of the gel burns CG extent and for muscle-planar wound using a standard model in rats. The experiment showed that the gel has a pronounced healing effect in the initial phase of wound healing and provides earlier complete wound healing as compared to the commonly used multi-component ointments.

The gel used to prepare the wound surface to free skin grafting in burns 2-ST degree. After it was noted good condition granulated tissue, made of skin plasticity. Engraftment of the graft was 100%.

It should be noted self-epithelization of the wound surface areas that are not closed with a skin graft, no unsightly scars. The tests took place with all the selected gelling the basics.

Trials have shown clinical efficacy of the proposed wound healing agent. So the way developed a universal composition with Mexidol, simple enough and technologically reproducible, meets all the requirements of the pharmaceutical and cosmetic industry, which can be recommended for widespread use for the treatment of wounds, erosions, trophic ulcers, burns, pressure sores and other skin lesions and mucous membranes, especially complicated by purulent-inflammatory processes.

The gel can also be used to improve the trophic tissue, varicose veins of the lower limbs, bruises, edema, hematomas, to improve the skin structure.

A wound healing agent, comprising gelling, the active substance and distilled water, characterized in that the active substance contains Mexidol (2-ethyl 6-methyl-3-oksipiridina succinate) in the following ratio, wt.%:

Gelling0,5-5,0
Stabilizerof 0.01 to 0.8
Preservative0,01-1,0
Mexidolof 0.01 to 10.0
Distilled water
deionizedRest



 

Same patents:

FIELD: medicine, therapeutic stomatology, dermatology.

SUBSTANCE: the present innovation deals with introducing desensitizing remedies, local application of hormonal preparation onto oral mucosa and, also, a keratoplastic preparation as 4%-chitosan water-insoluble colloid solution at deacetylation degree of 0.95, molecular weight of 100-120 kD. This preparation should be applied with a thin layer onto affected parts of oral mucosa for 30 d which should be pre-treated with 1%-hydrogen peroxide solution and dried. Then therapy should be continued with the above-mentioned chitosan solution once daily after meals and once nocturnally, for 30 d, as well. The innovation provides quick interruption of inflammation, complete epithelization due to high adhesion of preparation at oral mucosa.

EFFECT: higher efficiency of therapy.

4 dwg, 2 ex, 2 tbl

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to manufacturing medicinal preparations with wound-healing effect, in particular, to preparation with wound-healing effect comprising an agent stimulating epithelization. The wound-healing agent comprises vitamin E in concentrations 0.01-5.0 wt.-% in chitosan gel. Preferable variant represents applying chitosan gel formed by fractionated low-molecular chitosan of molecular mass from 10 to 20 kDa, or from 20 to 50 kDa, or from 50 to 300 kDa taken in the concentration from 1.0 to 10.0 wt.-%. Except for, it is possible additional applying antibacterial agent in wound-healing agent taken among the following order: chloramfenicol, lyncomycin, metronidazol, ciprofloxacin, benzalkonium chloride, additional using an antibacterial agent and lidocaine in agent, additional using an antibacterial agent and adrenaline in agent, and additional using hydrocortisone in the concentration 0.5 wt.-% in agent. Invention provides preparing wound-healing effect that occurs early essentially in epithelization and without formation of colloidal scars and reduces time for appearance of tissue regeneration markers.

EFFECT: valuable properties of agent.

8 cl, 2 tbl, 3 ex

FIELD: medicine, surgery.

SUBSTANCE: method involves every day covering a wound with an agent comprising of pig spleen homogenate and oxygenated with perfluorane taken in the following amounts: 100 g of pig spleen homogenate and 10 ml of oxygenated perfluorane. Invention promotes to accelerating sanitation of suppurative wounds due to activation of topical immunity and activation of regenerating processes. Invention can be used in treatment of suppurative wounds.

EFFECT: improved treatment method of wounds.

2 ex

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to curative ointments with anti-inflammatory effect and with biostimulating properties for treatment of burns, suppurative and infected wounds of different etiology and to a method for treatment above said diseases using the ointment said. The proposed ointment comprising bee wax and greasy basis comprises colophony additionally. As greasy basis the ointment comprises butter and vegetable oil in the following ratio of components, wt.-%: bee wax, 20-30; butter, 30-40; vegetable oil, 15-25; colophony, 15-25. Method involves applying ointment by thin layer 0.5-3 mm on dense cotton fabric, its applying to damaged site, keeping and removing ointment with change of bandage 1-3 times per 24 h for 3-14 days. Method provides enhancing the therapeutic effectiveness of ointment due to significant acceleration the healing process of suppurative wounds and insidious furuncles being the ointment doesn't cause irritating effect.

EFFECT: improved and valuable medicinal properties of ointment.

2 cl, 4 ex

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to medicinal preparations used for treatment of suppurative wounds. Invention involves applying boric acid (powder) and multi-component ointments on water-soluble base (Laevomecolum or Laevosinum) taken in the ratio 1:10 and used for treatment of suppurative wounds. Invention provides the development of agent exhibiting the expressed antibacterial, dehydrating and necrolytic effect.

EFFECT: valuable medicinal properties of agent.

2 ex

FIELD: medicine, dermatology.

SUBSTANCE: one should apply an applicator onto affected parts of skin that contains 5-aminolevulinic acid at concentration of 5-20%. After keeping and removing the applicator it is necessary to irradiate with light at wave length being 630 ± 10 nm and energy density of 10-1200 J/sq. cm. Control should be carried out due to evaluating the concentration of photosensitizer at affected parts of skin due to fixing fluorescence ranges at all basic stages of photodynamic therapy. The method enables to adjust skin relief and achieve scars' whitening and their regression.

EFFECT: higher efficiency of therapy and control.

6 cl, 2 dwg, 3 ex

FIELD: pharmaceutics.

SUBSTANCE: the innovation deals with manufacturing remedies to prevent wound suppuration based upon polymeric matrix and antimicrobial substance due to mixing components in solution, forming the film to obtain a powder-like medicinal form by providing the safety of antimicrobial activity of medicinal preparation. The obtained remedy is completely biodestructed in the body and requires no repeated operation on its removal after the end of tissue regeneration processes.

EFFECT: higher efficiency of manufacturing.

1 cl, 3 ex, 1 tbl

FIELD: medicine.

SUBSTANCE: the present innovation deals with preparing ointments to be applied at treating both surface and deeply penetrating cutaneous burns and other skin diseases, as well. Composition of the suggested ointment includes, weight%: 45…67% food sunflower oil, 15…37% food olive oil, 1…2% Calendulae officinalis extract, 0.8…1.8% labdanum, 2.5…8% colophony, 6.5…11.5% white bee wax, 0.7…1.8% the main bismuth gallate and 0.7…1.8% camphor. The suggested ointment is highly efficient for rapid and successful treatment of burns III and IV degree. It should be also applied for treating shin's ulcer and, also, in gynecology - for treating inflammation of uterine cervix.

EFFECT: higher efficiency of therapy.

4 ex

FIELD: medicine.

SUBSTANCE: the present innovation deals with treating different wounds. The suggested perfluorocarbon emulsion is being used as the medium in case of ultrasound treatment of wounds. Moreover, the enhancement of reparative processes is observed in the wound along with accelerated wound healing due to development of perfluorophages in area of inflammatory process and to higher gas saturation of perfluorocarbon emulsion against other media applied before. The emulsion under the action of low-frequency ultrasound obtains other properties (increased specific weight, increased fluidity, higher wettability of purified surface, the presence of abrasive properties) necessary for achieving technical result. All these measures, thus, enhance reparative processes in the wound because low-frequency ultrasound raise to a higher power the action of perfluorocarbon emulsion both regarding ultrasound purification and its curative action upon wound.

EFFECT: higher efficiency.

5 dwg, 1 ex

FIELD: medicine, pharmaceutical, cosmetic and food industry.

SUBSTANCE: method involves destruction and hydrolysis of alga taken among the group including: laminaria, zooster and focus followed by separating the cytoplasmatic fraction and addition of food acid polyvalent metal salt. Then correction of acidity is carried out to obtain pH = 5-7 followed by drying and conversion of fraction to form useful for storage by sterilization or freezing, or drying, or preserving. The food acid polyvalent metal an aqueous solution is added preferably in the amount 0.75% of preparation mass. Invention provides expanding functional capacity of the preparation with respect to stimulation of processes in healing wounds and burns, regeneration of post-traumatic damages, oncoprotecting and photo-sensitizing activity with respect to cancer cells at maximal absorption of light radiation in the region 630-770 nm.

EFFECT: improved producing method, valuable medicinal properties of preparation.

11 cl, 3 ex

FIELD: medicine, arthrology, pharmacy.

SUBSTANCE: agent comprises glucosamine salt as saccharide, dimethylsulfoxide, ointment base and ibuprofen or nimesulide, or piroxicam, or meloxicam, or diclofenac salt, or indometacin, or ketoprofen as a nonsteroid anti-inflammatory agent. Glucosamine hydrochloride, glucosamine sulfate sodium, potassium or calcium salt is used as glucosamine, and diclofenac potassium or sodium salt is used as diclofenac salt. New ointment shows high perfusion rate of active substances to the articulation zone and enhanced effectiveness. Invention expands assortment of agents used in treatment of articulations.

EFFECT: improved, enhanced and valuable medicinal properties of agent.

2 cl, 14 ex

FIELD: cosmetic industry, cosmetics.

SUBSTANCE: invention relates to a method for preparing a base for cosmetic agents used in skin care. Method for preparing biologically active base for cosmetic agents comprises fermentation of cultures of strains lactobacilli and bifidobacteria in hydrolyzate-milk medium containing lactulose. The ferment of lactobacilli and bifidobacteria in the amount 3-5% of nutrient medium volume is plated and fermented for 6-8 x up to formation of suspension with acidity value = 70°-100° and with titer value 1010 CFU followed by its heating at temperature 80-85°C for 10-15 min and cooling. The content of lactulose in medium is 1.5-2 wt.-%. The base prepared by proposed method provides reducing loss of biologically active substances to minimal value and allows conferring to the base high nutrient activity and producing regenerating, softening, bactericidal and anti-inflammatory effects on skin.

EFFECT: improved preparing method, improved and valuable medicinal and cosmetic properties of base.

2 cl, 1 tbl, 4 ex

FIELD: medicine, dermatology, chemical-pharmaceutical industry, pharmacy.

SUBSTANCE: invention relates to an antifungal gel pharmaceutical composition based on ketoconazole and clotrimazole that are derivatives of imidazole. The composition comprises ketoconazole or clotrimazole as an active component, polyethylene glycol-400 (PEG-400) as a solvent, carboxyvinyl polymer as a gel-forming agent, polyethylene glycol as a gel stabilizing agent, organic amine or inorganic bas as a regulator of pH and water taken in the definite ratio of components. The composition is prepared by dissolving active component in PEG-400, dispersing carboxyvinyl polymer in water, successive addition to dispersion propylene glycol as a stabilizing agent and regulator of pH and combination of prepared solution and gel followed by stirring the mixture up to preparing the gel composition with pH 5-7. Invention provides preparing antifungal composition with reduced adverse effect.

EFFECT: improved preparing method, valuable medicinal properties of composition.

2 cl, 1 tbl, 11 ex

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to curative ointments with anti-inflammatory effect and with biostimulating properties for treatment of burns, suppurative and infected wounds of different etiology and to a method for treatment above said diseases using the ointment said. The proposed ointment comprising bee wax and greasy basis comprises colophony additionally. As greasy basis the ointment comprises butter and vegetable oil in the following ratio of components, wt.-%: bee wax, 20-30; butter, 30-40; vegetable oil, 15-25; colophony, 15-25. Method involves applying ointment by thin layer 0.5-3 mm on dense cotton fabric, its applying to damaged site, keeping and removing ointment with change of bandage 1-3 times per 24 h for 3-14 days. Method provides enhancing the therapeutic effectiveness of ointment due to significant acceleration the healing process of suppurative wounds and insidious furuncles being the ointment doesn't cause irritating effect.

EFFECT: improved and valuable medicinal properties of ointment.

2 cl, 4 ex

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to medicinal preparations used for treatment of suppurative wounds. Invention involves applying boric acid (powder) and multi-component ointments on water-soluble base (Laevomecolum or Laevosinum) taken in the ratio 1:10 and used for treatment of suppurative wounds. Invention provides the development of agent exhibiting the expressed antibacterial, dehydrating and necrolytic effect.

EFFECT: valuable medicinal properties of agent.

2 ex

FIELD: medicine, in particular homoeopathic ointment for treatment of hemorrhoids, dermatitis and rhinitis.

SUBSTANCE: claimed ointment includes Calendula D 1, Hamamelis D 1, Aesculus D 1, and menthol as active ingredients and zinc oxide and vaseline as ointment base in specific ratio. Ointment of present invention makes it possible to improve microcirculation and cell respiration in tissues, to reduce venous engorgement, to increase immunity, to stimulate regeneration processes.

EFFECT: ointment for treatment of hemorrhoids, dermatitis and rhinitis of improved effect.

1 tbl

FIELD: medicine.

SUBSTANCE: the present innovation deals with preparing ointments to be applied at treating both surface and deeply penetrating cutaneous burns and other skin diseases, as well. Composition of the suggested ointment includes, weight%: 45…67% food sunflower oil, 15…37% food olive oil, 1…2% Calendulae officinalis extract, 0.8…1.8% labdanum, 2.5…8% colophony, 6.5…11.5% white bee wax, 0.7…1.8% the main bismuth gallate and 0.7…1.8% camphor. The suggested ointment is highly efficient for rapid and successful treatment of burns III and IV degree. It should be also applied for treating shin's ulcer and, also, in gynecology - for treating inflammation of uterine cervix.

EFFECT: higher efficiency of therapy.

4 ex

FIELD: pharmaceutics.

SUBSTANCE: the present innovation deals with cryoprotective ointment containing recombinant interferon-α2. The suggested cryoprotective ointment contains recombinant interferon-α2, glycerol, polyethylene glycol 300-6000, polyglucin, buffered 0.02%-Trilon B solution at pH of 5.5-7.0 and ointment foundation at a certain content of components per 1.0 g ointment. Additionally, cryoprotective ointment could contain glycine 3,7-bis(dimethylamino)phenothiazonium chloride, dry immunoglobulin preparation or dry immunoglobulin preparation for enteral application. Ointment foundation of cryoprotective ointment could contain water-free lanolin, Vaseline and Vaseline oil, at the following ratio of components: 2.5;3.5:1 - 6.5:0.5:1. The innovation provides maximal safety of recombinant interferon-α2 activity in cryoprotective ointment at multiple alteration of positive and negative environmental temperature and at keeping cryoprotective ointment under these conditions.

EFFECT: higher efficiency of application.

8 cl, 8 ex

FIELD: pharmaceutics.

SUBSTANCE: the suggested composition has got viscosity being below of about 15000 cP and pH being approximately 3.0-9.0 for treating human skin diseases. He suggested composition consists of (a) therapeutically efficient quantity of, at least, one compound being useful in treating the above-mentioned disease; (b) pharmaceutically acceptable, partially bound polymer of polyacrylic acid being compatible with the compound; (c) not obligatory, a solvent being mixed with water, (d) not obligatory, a conserving agent, (e) not obligatory, a component of butyric phase and acceptable surface-active substance, and (f) water. The suggested composition is useful to treat inflammatory skin disease, acne or acne erythematosa. The composition of low viscosity has got its advantage in the fact that it is applied more accurately when in contact with a container that doses the composition in the form of drops.

EFFECT: higher efficiency of application.

23 cl, 15 ex, 19 tbl

FIELD: medicine, gynecology, pharmacology, pharmaceutical industry.

SUBSTANCE: invention proposes a preparation that comprises bacterial mass of live microorganisms as an active component, protecting medium and fat base. The preparation comprises lactobacilli as bacterial mass and one or some eubiotic microorganisms taken among the following group: bifidobacteria, streptococci and lactococci taken in the amount per a single dose. Also, the preparation comprises additionally an acceptable sorbent and a biologically active supplement. Also, invention relates to a method for preparing this preparation that involves preparing firstly lactobacilli bacterial mass and one or some genus of eubiotic microorganisms taken among the following group: bifidobacteria, streptococci and lactococci. Then the prepared bacterial mass of microorganisms is immobilized on sorbent used in medicine in its ratio to bacterial mass of microorganisms = (9-1):(1-9) followed by addition of the protecting medium and biologically active supplement to formed mass in the necessary amount. Also, invention describes a method for prophylaxis and treatment of bacterial vaginitis that involves intravaginal administration of the preparation described above in the amount 1-3 doses, 1-3 times per 24 h. The treatment course is prescribed individually. Invention provides expanding assortment of agents used for treatment of bacterial vaginitis. Invention can be used in obstetric-gynecological practice.

EFFECT: improved method for vaginitis treatment, valuable medicinal properties of preparation.

13 cl, 4 tbl, 1 ex

FIELD: medicine, immunology, narcology, biochemistry.

SUBSTANCE: invention elates to correction of immune disturbances in opium narcomania. Method is carried out by administration of an immunomodulating agent, 2-ethyl-6-methyl-3-oxypyridine succinate, in period for arresting opium abstinent syndrome by intravenous route, 2 times per a day in daily dose 0.1-0.4 g for 5-7 days, and at the stage of post-abstinent state - by intramuscular route in daily dose 0.1-0.2 g, 2 times per a day for 7-14 days, and at the reablement stage - by intramuscular route in daily dose 0.1-0.2 g every other day for 3-4 weeks. Method provides reducing activity of lymphocyte NO-synthase and normalization of immunocytogram picture.

EFFECT: improved method for correction.

2 ex

Up!