The method of identifying the location of functionally similar areas in anatomically complete the fields receptive sensitivity

 

The invention relates to the field of neurophysiology and physiology of sensory systems, exploring the integration of visceral and somatic analyzers, and can be used to create refleksodiagnostika systems for diagnostics of the condition of the body and diseases of the internal organs. The method includes the irritation or inhibition of receptors one of the predefined areas of the first receptive field sensitivity, registration reaction rhythmic activity potentials of the brain, which determine their frequency and amplitude before and after stimulation or inhibition of receptors. Then the same work performed sequentially on all defined zones of different receptive field sensitivity and equality reactions rhythmic activity of the brain potentials identified in the surveyed areas of the receptive field sensitivity, make a conclusion about the functional similarity of these zones. For pickup reactions potentials rhythmic brain activity electrodes placed in the temporo-parietal and frontal derivations. The process is carried out at the time, much larger than the period of the lowest recorded frequency. The method provides an opportunity to objectively identify funk is eljnosti. 1 C. p. F.-ly, 20 ill.

The invention relates to the field of neurophysiology and physiology of sensory systems, exploring the integration of analytic systems, more specifically the integration of visceral and somatic analyzers, and can be used to create refleksodiagnostika systems for diagnostics of the condition of the body and diseases of internal organs.

Known methods of detecting the location of functionally similar areas in anatomically complete receptive fields of sensitivity, including "mapping" representations skin analyzer in somatosensory area postcentral gyrus cortex of the human brain, which, by comparing the points of irritation on the skin surface with dots of bark, giving the maximum response, find the "projection" of different areas of the body surface in somatosensory cortex "point to point". In primary somatosensory area there is a high degree of topographic organization scheme of the body and signs of meta-dimensions (see books Adrian E. D. Double representation of the feet in the sensory cortex of the cat. J. Phiziol., 1940, v.98, pl6.; Mountcastle V. B. Medical Pfysiology, v.2, St. Louis, 1968; Darian-Smith I. Somatic sensation. - Ann. Rev. Physiol., 1969, v.31, p.417, and close enough stated capitalista visceral systems", Nauka, Leningrad, 1973, s.). Because somatic and visceral afferent systems have in the cortex of the same topical representation with the typical "one metameric" the plan of the building, this allows the interaction of both systems (viscero-somatic integration) at all levels of the brain and spinal cord as in the primary projection areas and associative fields of sensitivity. The "map" representation of visceral systems in the brain cortex obtained by the method of evoked potentials, However, this "map" can be used in the diagnosis of conditions of the internal organs only in the acute experience. To remove from the scalp information about the status of individual elements of maps (high resolution) is not possible (when renting the EEG from the scalp of the distance between the electrodes is less than 2 cm is not justified. When the size of the Central sulcus 5-6 cm this gives a very low accuracy of topographic measurements. Shevelev I. A. Functional brain mapping/ W-L. the Success of the physiological Sciences. 1987, 18 so. 2. S. 17). In this regard, the above-mentioned methods are purely methodological value not found application in practical medicine.

Seceptible sensitivity including irritation of one of the predefined areas of the first receptive field sensitivity and the subsequent examination of all specified other areas receptive field sensitivity with detection of the location of the zone, reacted to this irritation (see the book of Kropa H. "a Brief guide to the auricular-acupuncture." Brochure 3.2.0. Systematics. Translated from the German Ed. by Professor F. G. Portnov, Riga. 1977).

This method has either low resolution (the minimum size of the detectable zone of the dermatome, if you use the methodology, correct positions, recognized by modern medicine), or characterized by subjectivity (acupuncture technology).

If we consider the listed known methods from the perspective of interaction between the two receptor field - field visceral sensitivity (internal organs) and the cutaneous somatic sensitivity, then it is implemented either on the basis of known segmental toiletries internal organs, either empirically (acupuncture), which introduces a considerable uncertainty in the interpretation of diagnostic information.

The challenge which aims stated the decision reflected in the increasing resolution sposobnostey to provide opportunities for identifying functionally similar areas of any given size, in addition, it eliminates the subjectivity of this process by introducing a single, easy-qualimetric objective setting, in addition, on the basis of this objective parameter provides the opportunity to identify functionally similar areas, regardless of the type of benchmark, anatomically complete receptive field sensitivity.

The problem is solved in that a method of identifying the location of functionally similar areas in anatomically complete receptive fields of sensitivity, including the stimulation of one of the defined areas on the first receptive field sensitivity and the subsequent examination of all specified other areas receptive field sensitivity with detection of the location of the zone, reacted to this irritation, characterized in that when the stimulation of one of the defined areas on the first receptive field sensitivity register maximum reaction rhythmic activity potentials of the brain, which determine their frequency and amplitude before and after stimulation, then the same work performed sequentially on all defined zones of different receptive field sensitivity then, with equal reactions rhythmic aktivnog sensitivity make a conclusion about the functional similarity of these zones. In addition, identify the difference between rhythmic activity in temporo-parietal and frontal derivations brain. In addition, for the removal of reaction potentials of rhythmic brain activity electrodes placed in the temporo-parietal and frontal derivations, the process is conducted at the time of integration, much larger than the period of the lowest recorded frequency.

Comparative analysis of the characteristics of the claimed solution with the characteristics of the prototype and analogues demonstrates compliance of the claimed solution to the criterion "novelty".

The characteristics of the characterizing portion of the claims, solves the following functional tasks: Feature "... when the stimulation of one of the defined areas on the first receptive field sensitivity register maximum reaction rhythmic activity of the brain potentials" provides an assessment of the reactions to stimulation zones in any anatomically complete receptive fields based on the sensitivity of using a single lightwelterweight (i.e. measured quantitatively) objective setting, the fixation of which is well established and legkosti.

Sign achival the possibility of detecting and fixing the parameters of the reaction receptive areas of irritation.

The sign "...then the same work performed sequentially on all defined zones of different receptive field sensitivity allows to detect the parameters of the reaction zones any other receptive field sensitivity, i.e., to obtain the objective material for comparative assessment.

Signs "...and then, with equal maximum reactions rhythmic activity of the brain potentials identified in the surveyed areas anatomically complete receptive field sensitivity, make a conclusion about the functional similarity of these zones provide a process of comparison.

Signs of the second and third claim of the invention provide improved accuracy and reliability evaluation.

In Fig. 1-3 are illustrations explaining the principles of organization "Segmental matrix used for topographic binding provisions of the surveyed areas on the body. In Fig. 1 shows directly Segmental matrix of Fig. 2 shows the segmental innervation of the body (divide its surface into dermatomes) of Fig. 3 - same - zonal innervation of the body (divide its surface into vertical zones); Fig. 4-9 show examples of the irritation of different topography of skin analysis is t "Segmental matrix: Fig. 4 is a view of the envelope of the power spectrum when the irritation anteromedian one line in the sacral segments of the spectral coordinate of the peak response (coordinate S2, F7-4 - here and later in the envelope spectrum solid line - right hemisphere, dotted - left); Fig. 5 is a view of the envelope of the power spectrum when the irritation sidesliding line (back) in the segment L3. The maximum response spectrum with coordinates (Fl-2, L3); Fig. 6 is a view of the envelope of the power spectrum when the irritation segment Th1 along the paravertebral line (back). The maximum response spectrum with coordinates (F2-1, Th1); Fig. 7 is a view of the envelope of the power spectrum when the irritation segment Th7 on axillary midline. The maximum response spectrum with coordinates (F4-2, Th7); Fig. 8 is a view of the envelope of the power spectrum when the irritation segment Th8-9 at the line of the abdomen, a few inches above and to the right of the navel. The maximum response spectrum with coordinates ( F7-2, Th9 ); Fig. 9 is a view of the envelope of the power spectrum when the irritation segment L5 on the line of the abdomen on the left. The maximum response spectrum with coordinates (F6-1, L5); Fig. 10 shows a powerful anomaly (asymmetry) in the spectral region with coordinates (F6-1, Th1); Fig. 11 shows the projection of the field of skin sensitivity on the outside on the species of nasal mucosa drug "IT". The maximum response synchronization of the left and right hemisphere was observed in cells "segmental matrix with coordinates (F2-4, Th3-4). In Fig. 14 shows the excited-beta-1 adrenergic receptors in the myocardium in segmental region ( Th1-Th3 ) - synchronization of the left and right hemisphere and the process of inhibition of beta-1 adrenergic drug INDERAL, Fig. 15 shows the maximum error in the activity of the left and right hemispheres (braking), is observed in cells "segmental matrix (F2-2, a Th1-Th4), and Fig. 16 and 17 shows the braking process of the M-cholinergic receptors zone of the gastric fundus drug GASTROTSEPIN (Fig. 16 - a shows the initial state of Fig. 17 is a direct response). Maximum inhibition (asymmetry of the left and right hemispheres) was observed in cells segmental matrix (F6-5, Th6-7); Fig. 18 and 19 shows the process of pronounced excitation of beta-2 adrenergic receptors region of the cervix drug GINIPRAL (Fig. 18 - a shows the initial state of Fig. 19 is a direct response). The maximum response of cells "segmental matrix is observed in the coordinates (Fl-4, L5); Fig. 20 shows the result of the sequential comparison and determination of zones with the same spectral response of the same cells in the grace of afferent systems, made by the following authors: A. S. Batuev, A. C. Waldman, R. A. Durinyan, E. W. life of our birds, and studies on nonspecific and activating functions of the brain: R. A. Durinyan, C. F. Ananin, etc.

When solving a task, it is important to have a system of coordinates in which the position of each zone of the receptive field sensitivity can be uniquely tied. Historically, that a research center and a kind of reference system in the integration of analyzers has become the most available to research in the field of skin sensitivity.

When implementing the claimed solution direction is in the description of the coordinate diagram of the body, based on the use of traces one metameric organization of a peripheral section of the Central nervous system. In the framework of this direction is known (authors A. M. Greenstein (1946), Hansen, Schilak (1962), M. B. Kroll (1936), Forster (1936), V. M. Bekhterev (1926) and others), in which the main principles viscerotonic integration using the concepts of "dermatomes" and "segments of the body" to describe the coordinates of the various interaction effects receptive field analyzer. It is known that the distribution of cutaneous nerves (mainly sensitive) trunk organizer is also proliferation of peripheral spenomegaly cutaneous nerves of the trunk and sensitive effector-sympathetic and secretory nerve fibers that Innervate smooth muscle, blood vessels and skin cancer) form a vertically oriented zones, which specify the appropriate division (zoning) of dermatomes on the plots. Zonal innervation forms columns segmental matrix (see Fig. 3). Segmental and zonal innervation of the skin is formed by various branches of the intercostal nerves.

Thus, Segmental matrix is a table h cells and occupies the spectral band from 27 to 0.1 Hz. On the vertical axis are the number of dermatomes - 32, horizontal - each dermatome is divided into 35 cells (7 zones, each of which, for greater accuracy, divided by 5 plots).

The method includes the following steps: - put the electrodes for the removal of the electroencephalogram with human head and connect them to the amplifier for registration reaction rhythmic activity potentials of the brain (as measured by their frequency and amplitude before and after stimulation); - for comparison, take at least two fields receptors odnomomentnoe or of multimodal chuvstvitelno one field sensitivity; in the recorded power spectrum of the electroencephalogram (frequency and amplitude potentials) are looking for a specific answer, which is different from the background removal by increasing the degree of synchronization of the left and right hemispheres on the specific spectral frequency (if receptors were excited) or increase the degree of asymmetry of power left and right hemispheres (desynchronization) on a specific spectral frequency (if receptors inhibited); - take the second field sensitivity and consistently irritate him receptors and record his answers in the power spectrum of the EEG; - areas of receptive fields with a single spectral frequency and response synchronization and / or timing, combined into one coherent structure. Many coherent (single-frequency) elements functionally identically regulated one coherent structure activating system of the brain, i.e., functionally similar.

To implement the method required electroencephalograph any known construction, providing a broad band of the signal (from 0.1 to 30 Hz), and the spectral signal analyzer electroencephalogram.

The method is as follows.

Register e is m electrodes Fs and TPs connected to the inputs "-" and "+" one of the differential amplifier electroencephalograph, and electrodes (Fd) and (TPd) is connected, respectively, to the inputs "-" and "+" other differential amplifier. In this connection the amplitude and frequency of the local left and right signal amplifiers is proportional to the functional activity of the Activating System of the Brain, or rather its "frontal" - brake and temporo-parietal" - activating regions.

The derivations analyze the amplitude and frequency of the local maxima and minima, and the degree of synchronization of the left and right hemispheres. The integration time of the signal is not less than 210 C. the Spectrum recorded in the range from 28 to 0.1 Hz.

Further steps based on the detected authors phenomenon spectral somatotopy odnodolnyh receptors sensitive fields, i.e., the topographic location of each receptor's sensitivity has a spectral difference. In addition, a significant spectral difference and have the answers at stimulation of receptors of different types of sensitivity. Irritation of the receptor leads to the appearance of the spectral maximum synchronously in the left and right hemispheres, inhibition of the receptor leads to asymmetry of the spectral density in the hemispheres. An illustration of this phenomenon is shown in " pain sensitivity of the whole body), why start with any necessary resolution to put a point of irritation receptors by any known method (for example, superficial skin prick until pain). After application of each of irritation register spectral power and frequency rhythmic activity of the Activating System of the Brain, secrete abnormally reacting to irritation spectral plots (clusters) and register them. Each topographic area receptive fields put my spectral maximum.

Take another functionally and anatomically complete field sensitivity of the same or another modality (e.g., the outer surface of the auricle) and start with any necessary topographic discontinuity to cause irritation of receptors (for example, pain - point injection needle to the pain). For each point of the field register spectral responses Activating System of the Brain and produce abnormal response to stimulation in the form of maximum response frequency and amplitude of the potentials of the brain.

Two points on different fields of sensitivity with the same spectral maximum, are regulated in one part of the receptors of these areas occur synchronously, they find a strong functional relationship.

Thus, two functionally and anatomically complete field sensitivity based on pointwise equality of their spectral characteristics of topographically to combine or make them functionally similar. While knowledge of the local sensitivity of one part of the field automatically leads to the knowledge of the status of such area of another field.

Take N-oe field sensitivity (field visceral receptors in internal organs, iris eyes, scalp, hand, foot, mucosa of the tongue, nose, etc.,) and in the selected coordinate system build functional similarity odnodolnyh or multimodal receptive fields with any desired topographical resolution.

The method allows to detect the functional status of any remote field sensitivity (visceral analyzer) is functionally similar, but easily accessible for analysis field (for example, the surface of the ear), and thereby to build a diagnostic system with any given accuracy and topographical resolution.

EXAMPLE 1. The construction of the functional similarity of two analytic fields of skin sensitivity.

Impose sensors and record the electroencephalogram in two leads - frontal left and right Fs, Fd; temporo-parietal left and right TPs, TPd. The electrodes Fs and TPs connected to the inputs "-" and "+" one differential amplifier (S), the Electrode Fd and TPd connected to inputs "-" and "+" another differential amplifier (D). The derivations analyze the amplitude and frequency of the maximum reaction potentials of the brain. The spectrum recorded in the range from 28 to 0.1 Hz, the integration time of the signal is not less than 210 C. the Irritation of different areas of the skin was carried out by needle - surface injection to pain. Before irritation was filmed background, after stimulation control 3 times for 20 minutes

At the beginning of the studied field cutaneous sensation in the body. When the irritation of the back of the brush, in the first pipestem between dorsal digital nerve p. digitalis dorsalis (C6,7,8) (area acupuncture points HAE-GU) in the power spectrum appeared anomalous component of 0.3 Hz. When you study other people (minimum 10 people) revealed recurring natural spectral region in the range of 0.27-0,316 Hz with a center frequency 0,307 Hz. Consistently taken any other skin ovie field areas of skin sensitivity on the one hand and the spectral characteristics of these sites when you register on the electroencephalogram of man (excited certain coherent structures of the brain).

Take the second field sensitivity for determining the relative functional projection - for example, the outer skin surface of the ear. Similarly spend irritation of the separate parts of the ear and record the response of the power spectrum of the EEG. For example, upon stimulation of the deepest region in the bowl of the ear (auricular point acupuncture 100) recorded the strongest anomaly (asymmetry) in the spectral region with coordinates (F6-1, Thi) - Fig. 10. Thus, each point of the surface of the ear corresponds to its frequency in the power spectrum of the electroencephalogram or specific cell in the "segmental matrix". Comparing the frequency organization of the cutaneous surface of the body and the outer surface of the auricle, highlighting areas with equal frequency spectrum, build mutual projection of the two fields of sensitivity. If the coordinate system is taken segmental matrix", it is inscribed in the first and in the second field of skin sensitivity (Fig. 11).

EXAMPLE 2. Building mutual projection of two analytic fields - the outer surface of the skin of the auricle and visceral receptors in internal organs (field interoreceptors). Wpisy the Example 1. Enter in the frequency coordinate system "segmental matrix" field interoreceptors internal organs, which consistently annoying (slow) receptors in the internal organs in any way, such as pharmacological blockers or mimetics of certain receptors.

In Fig. 12 shows the inhibition and excitation (Fig. 13) alpha adrenoreceptor vessels of the nasal mucosa drug "IT". The maximum response synchronization of the left and right hemisphere was observed in cells "segmental matrix with coordinates (F2-4, Th3-4).

In Fig. 14 shows the excited-beta-1 adrenergic receptors in the myocardium in segmental region (Th1-Th3) - synchronization of the left and right hemisphere and the process of inhibition of beta-1 adrenergic drug INDERAL.

The maximum error in the activity of the left and right hemispheres (inhibition) was observed in cells "segmental matrix (F2-2, a Th1-Th4) (Fig. 15). In Fig. 16 and 17 shows the braking process of the M-cholinergic receptors zone of the gastric fundus drug GASTROTSEPIN. Maximum inhibition (asymmetry of the left and right hemispheres) was observed in cells segmental matrix (F6-5, Th6-7).

In Fig. 18 and 19 shows the process expressed excitement "beta 2" adrenopause in the coordinates (Fl-4, L5). Thus, different groups of receptors visceral field sensitivity are transferred into the system spectral coordinate segmental matrix".

Build the projection field of interoreceptors internal organs on the field of skin sensitivity outer surface of the auricle, sequentially comparing and determining the fields with the same spectral response (the same cells in the segmental spectral matrix). The result of this sequential comparison is shown in Fig. 20.

With this method of construction is easily achieved resolution field mapping sensitivity 1000 or more cells with high accuracy. Resolution acupuncture methods of mapping the outer surface of the auricle on the order of less - 110 acupuncture points, reflecting the state of the internal organs of the International European classification.

On the basis of the present invention can be constructed of an effective system of diagnostics of diseases of internal organs.

Claims

1. The method of identifying the location of functionally similar zones in the receptive fields of sensitivity, including rasdr is the R other zones receptive field sensitivity characterized in that during stimulation or inhibition of receptors one of the predefined areas of the first receptive field sensitivity register response rhythmic activity potentials of the brain, which determine their frequency and amplitude before and after stimulation or inhibition of receptors defined zones of the first receptive field sensitivity, then the same work performed sequentially on all defined zones of different receptive field sensitivity, and then, with equal reactions rhythmic activity of the brain potentials identified in the surveyed areas of the receptive field sensitivity, make a conclusion about the functional similarity of these zones.

2. The method according to p. 1, wherein for removal of the reaction potentials of rhythmic brain activity electrodes placed in the temporo-parietal and frontal derivations, the process is carried out at a time much larger than the period of the lowest recorded frequency.

 

Same patents:

The invention relates to the field of medicine and medical equipment, namely to bioinformatics molecular clinical diagnostics

The invention relates to the field of medicine, reflexodiagnostics and vertebrogenic

The invention relates to medical equipment and can be used to assess the electrophysiological state of the acupuncture points (TA) in reflexogenic and reflexology, as well as to search for THE

The invention relates to medical information and measuring equipment and can be used in specialized diagnostic information systems and stand-alone devices for medical institutions intended for diagnostic studies according to the method of R. Voll

The invention relates to medical equipment, namely, devices for obtaining information when conducting diagnostic tests on the parameters of the skin at acupuncture points

The invention relates to medical equipment and can be used for diagnostic purposes, namely for the rapid and non-invasive assessment of functional state of man, his organs and systems

The invention relates to medical information and measuring equipment and can be used in specialized diagnostic information systems and stand-alone devices for medical institutions intended to diagnose, according to the method of R.

The invention relates to medicine and veterinary medicine in the diagnosis of relevant biological organisms
The invention relates to medicine, Oncology

The invention relates to medicine and can be used in the treatment of diseases through effects on biologically active points

The invention relates to medicine, namely to neurophysiology, neuroregenerative, neurology and neurosurgery, and can be used to predict treatment outcomes of patients with persistent vegetative state (PVS)
The invention relates to medicine and can find application in neuro-ophthalmology

The invention relates to medicine, namely to clinical physiology, neurology, neurotraumatology, neuroanesthesiology

The invention relates to medicine, namely to psychiatry

The invention relates to medicine, namely neurosurgery and neurology, may be used to identify the focus of epileptic activity in patients with epilepsy

The invention relates to medicine, namely to Pediatrics, and can be used to predict the course and outcome of the disease in children with respiratory distress syndrome
The invention relates to medicine, namely to methods for recovery psikhofiziologicheskikh parameters of the body using electroencephalographic biological acoustic feedback (EEG-BOS), and can be used in various fields of medicine in the treatment of a wide range of diseases, such as functional disorders of the Central nervous system, psychosomatic diseases and effects of organic brain damage

The invention relates to medicine, namely to psychiatry and neurology, and can be used as a method of revealing hidden epileptogenesis

FIELD: medicine, neurology, psychopathology, neurosurgery, neurophysiology, experimental neurobiology.

SUBSTANCE: one should simultaneously register electroencephalogram (EEG) to detect the level of constant potential (LCP). At LCP negativization and increased EEG power one should detect depolarizational activation of neurons and enhanced metabolism. At LCP negativization and decreased EEG power - depolarized inhibition of neurons and metabolism suppression. At LCP positivation and increased EEG power - either repolarized or hyperpolarized activation of neurons and enhanced metabolism. At LCP positivation and decreased EEG power - hyperpolarized suppression of neurons and decreased metabolism of nervous tissue. The method enables to correctly detect therapeutic tactics due to simultaneous LCP and EEG registration that enables to differentiate transition from one functional and metabolic state into another.

EFFECT: higher accuracy of diagnostics.

5 dwg, 1 ex, 1 tbl

Up!