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RussianPatents.com
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Method of treating ulcerous pyloroduodenal stenosis Invention refers to medicine and can be used for treating ulcerous pyloroduodenal stenosis. That is ensured by single injections of patient's platelet rich plasma into a gastric mucosa on the periphery of scar tissues of a pyloric canal all around uniformly into 6 points in a dose of 0.2 ml. Then the stenotic area is exposed to ionised argon plasma for 5-8 days in a mode of unipolar spray coagulation at a power of 30 W, an argon flow of 1.5 litres a minute for 5-6 seconds; the number of exposures per one session makes 3 to 5. |
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Ointment consists of emulsion base and pharmacologically active substance. The pharmacologically active substance of the ointment is presented by a fraction having a boiling temperature of 170-215°C (5-6 mm Hg) prepared by yolk pyrolysis on montmorillonite clay at 250-280°C for 20-30 min. The ointment also contains Carbomer, monoglycerides, hydrogenated coconut oil, glycerol, stearic acid, liquid paraffin, ethanol, myristyl myristate, hydrogenated lanolin, butylene glycol, polydimethyl siloxane, dimethicone, Nipagin, Nipasol, and a flavouring agent in certain proportions. |
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Invention refers to biotechnology and concerns cDNA coding human dysferlin, a genetically engineered construct wherein such cDNA is cloned, a recombinant adenovirus and a pharmaceutical composition. The described genetically engineered construct comprises an expression plasmid adenovirus vector pAd/CMV/V5-DEST, wherein the codon-optimised cDNA having a sequence presented in SEQ ID NO: 1 and coding human dysferlin is cloned according to recombination sites attB1 and attB2. The recombinant replication defect adenovirus serotype 5 is prepared with using such genetically engineered construct and included into the pharmaceutical composition in an effective amount. |
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Parenteral composition, method for preparing and using composition Invention refers to pharmaceutical industry, namely to an immunomodulatory composition for injection into a mammal. The immunomodulatory composition for injection into a mammal containing a hydrolysate prepared by acid and/or enzymatic hydrolysis of one or more bioresources specified in a group consisting of bivalve molluscs, annelids, leeches, and water taken in certain proportions. A method for preparing the immunomodulatory composition for injection into a mammal. A method of treating a pathological condition in a mammal in need thereof involving the injections of the immunomodulatory composition into the above mammal. Using the composition for normalising metabolism into the mammal in need thereof. |
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Method for skin restoration in patients with vast wounds with soft tissue defects (versions) Waste skin is incised on the periphery of the wound. The incised skin is prepared from the residual subcutaneous fat and milled to fragments having an area of 1-2 mm2. A dermal matrix made of dead donor's tissue is simulated after the wound shape. The dermal matrix (DM) is perforated to create traumatic discharge outflow tracts and laid on a wound bed so that to form a diastasis between perforation edges. Patient's waste skin fragments are introduced into the perforations in a staggered order. The wound is closed with a sterile gauze dressing. The other invention is allogenic mesenchymal multipotent stromal cell (MMSC) transplantation onto the wound bed in the form of the suspension by means of injections at a depth of 0.1-0.3 mm at a rate of 10 injections per 1 cm2. A volume of each injection makes 0.05-0.1 ml. The dermal matrix made of dead donor's tissue is simulated after the wound shape. That is perforated to form the traumatic discharge outflow tracts and laid on the wound bed. The wound is closed with the sterile gauze dressing. The effect is ensured by using the DM as an optimum biocompatible cell carrier and creating a required micromedium in the wound, stimulating the regeneration processes ensured by a combination with the homogenised autologous skin or allogenic MMSC injections into the wound. |
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Combined graft (CG) represents a dermal matrix (DM) prepared of a donor layer with self-specific multipotent mesenchymal stromal cells (MMSC) colonised on the surface thereof to the number of not less than 750-1500 thousand per 1 cm2. The group of inventions also refers to a method for preparing the combined graft involving bone marrow sampling from the patient, preparing a MMSC culture, applying a MMSC suspension in the concentration of not less than 1 million/ml on the DM surface at 1 million MMSC per 5 cm2 of the DM. |
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Method for local wound healing involving using a biological dressing which is applied on a wound surface. The biological dressing contains a polymer base of a hydrophobic perforated silicone film coated with a layer of human collagen type I and human diploid cells. The biological dressing is square-shaped and contains the diploid cells in the form of the characterised live cells of M-20 human fibroblasts at the level of passages No. 20-33 in the form of cell monolayers of 70-80% saturation density prepared at a starting density of (4-5)×104 cells per 1 cm2 of the dressing and culturing in a nutrient medium with fibrinolytically active plasma added. Vast injuries may require placing a desired number of the line-on-line dressings on the wound surface. Preferentially, the dressing is applied from the 1st-2nd post-injury day. |
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Method for prevention of developing bacterial intestinal infection Group of inventions refers to medicine, namely to medical microbiology, and can be used for treating intestinal yersiniosis, or pseudotuberculosis, or salmonellosis experimentally. That is ensured by simulating one of the above pathologies in experimental animals followed by oral administration of therapeutic preparations in therapeutically effective doses with controlling the content of pathological microflora for a period of time providing elimination of the disease. Stimbifid or a culture fluid of lactic acid bacilli is administered orally as the therapeutic preparation into each animal for the first 2 hours after infection once a day as a monotherapeutic preparation promoting the colonisation resistance of the intestinal mucosa to an agent. Stimbifid is administered into each animal in a dose of 13 mg for 5 days from the moment of the infection, while the culture fluid is administered in an amount of 0.2 ml throughout 7 days from the moment of the injection. What is also presented is a method for preparing an agent for treating intestinal yersiniosis, or pseudotuberculosis, or salmonellosis experimentally. |
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Pharmaceutical composition and method for preparing antiviral fractions (antivirus-c) Group of inventions refers to medicine and aims at cell protection against the cytopathogenic action of hepatitis C virus. What is declared is a pharmaceutical composition possessing antiviral action on hepatitis C virus and a method for preparing it. The chicken broiler's head is electrically stimulated in a mode of 100-120 V 3-4 A for 3-4 s. The blood is sampled and incubated at 4-8°C for 18-24 hours. The serum is sampled. The sampled serum is filtered through a filter of a pore size of 10 nm, lyophilised and irradiated in a line electron accelerator (LEA) in a mode of 10-40 kGy. |
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Method of evaluation of antivariolic activity of therapeutic and prophylactic preparations Method of evaluation of antivariolic activity of therapeutic and prophylactic preparations comprises administering to the body of the animal model of control and test groups in a predetermined scheme of suspension of investigational antiviral preparation. Their intranasal infection is carried out with the strain of monkeypox virus, followed by incubation of the virus in animal bodies. The concentration of virus in the lungs of animals is determined, followed by the calculation of estimated indicators. The animal model is used as ordinary steppe heterosexual marmots Marmota bobak of 1-2-year-old age. The strain of monkeypox virus the strain of monkeypox virus V79-1-005 is used, deposited in the State collection of causative agents of viral infections and rickettsial diseases of the Federal budget institution of science State Research Centre of Virology and Biotechnology "Vector" under the registration number V-309. |
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Method for production of anti-luteolytic blood - AlB is that luteolisate is administered subcutaneously to gelding twice with an interval of 14 days at a dose of 20 ml each, containing parts of the corpus luteum of pregnancy of cows, and after 14 days after the second administration the blood is taken from the jugular vein. The method of treatment and prevention of persistent corpus luteum, subinvolution of uterus and postpartum endometritis in cows comprises at the background of general therapy the use of anti-luteolytic blood that is administered subcutaneously in the neck region twice at a dose of 10 ml each with an interval of 6 days. |
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Biomaterial and preparation with biomaterial, stimulating anti-tumour activity Described is biomaterial, stimulating the anti-tumour activity, which contains lyophilisate of postnatal induced lymphatic nodes (PNILN) of a patient with cancer. Described is a preparation, stimulating the anti-tumour activity, which contains as an active substance lyophilisate of PNILN of the patient with cancer, and as a solvent, water for injections, cremofor RH-40, an emulsifier T-2, peach oil, glycerol, Kollidon CL-M and benzyl alcohol with the specified component ratio. |
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Invention relates to the pharmaceutical industry, in particular to the application of the lanocholesterol fraction of wool grease as a bioemulsifier for cosmetic anti-aging preparations. Application of the lanocholesterol fraction of wool grease as the bioemulsifier for cosmetic anti-aging preparations is obtained by alkaline hydrolysis of wool grease with a mixture of ethanol, sodium hydroxide, pyrogallol and water, or with a mixture of ethanol, sodium hydroxide, pyrogallol, toluene and water, taken in a specified ratio, with further separation and purification under certain conditions. |
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Ointment for burns, folliculitis, furunculosis, vasculitis treatment and wound healing Invention refers to the pharmaceutical industry, namely to an ointment for burns, folliculitis, furunculosis, vasculitis treatment and wound healing. The ointment for burns, folliculitis, furunculosis, vasculitis treatment and wound healing containing: bees wax, line seed oil, kerosene and visceral fat of pig taken in certain proportions. |
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Nutritive composition for mammal immune system improvement Inventions group relates to food industry. The nutritive composition for improvement of the immune system with a mammal, preferably, with the human includes the following components: (a) at least 18 en% of protein material; (b) at least 12 wt % of leucine of the total quantity of protein material; (c) lipid fraction including at least one ω-3 polyunsaturated fatty acid chosen from the group consisting of eicosapentaenoic acid, docosahexaenoic acid, eicosatetraenoic acid and docosapentaenoic acid; (d) immunomodulator. |
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Method of production of bacteriophage Method of production of bacteriophage comprises: inoculation with the bacterial culture of the host strain in the titre of 108-109 CFU/ml in the vessel for culturing on the slant having a layer thickness from 10 mm to 25 mm, culturing for 3-3.5 hours at optimum temperature for growth of the host strain culture, then on the resulting lawn of culture of the host strain the stock bacteriophage is inoculated in the titre 105-106 CFU/ml and cultured for 13-15 hours at the optimum temperature and the thickness of the air layer over the surface of the solid medium of 25 mm to 40 mm. the phage lysate is prepared and sucked into a sterile container, chloroform is added, incubated for 30-45 minutes with continuous shuttling. The supernatant is centrifuged and sterilised by filtration through the filter with a pore diameter of 0.2-0.22 microns. |
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Allogenic multipotent mesenchymal stromal cells in the number of 6 million cells/kg are introduced intravenously in a dose of 3.0 Gy into rats suffered from radiation exposure. Additionally, haemopoietic stem cells recovered from umbilical blood in the number of 300 thousand cells/kg are introduced. The cells are transplanted in such a manner 60 min after radiation exposure. |
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Method of treating septic wounds with using modified montmorillonite clay Experimental wound is cleaned daily, first with normal saline (NaCl), and then coated with modified montmorillonite clay containing 0.1 to 4.35 wt % of silver. The preparation is introduced into the wound in an amount of 0.1 g per a wound of 1.5 cm in diameter. |
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Method for endothelial protection with api-phytocomposition Method involves simulating endothelial dysfunction in Wistar male rats by daily intraperitoneal introduction of L-nitro-arginine-methyl ester 25 mg/kg/day for 7 days. Endothelial dysfunction is corrected by intragastric introduction of an api-phytocomposition in the form of an aqueous suspension of honey, royal jelly, bee bread, Resveratrol in the ratio of 10:1:1:2. The composition is introduced in a dose of 200 mg/kg of an animal's body weight once a day for 7 days. |
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Method for hepatic protection with api-phytocomposition Method involves simulating hepatitis by 7-day alcoholisation in female rats. A hepatoprotective agent is presented by an api-phytocomposition in the form of an aqueous suspension of honey, lecithin and licorice root extract in the ratio of 10:2:1. The composition is introduced twice a day intragastrically before feeding in a dose of 200 mg/kg of body weight 5 days before ethanol introduction and for 7 days one hour before ethanol introduction. |
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Method for immune correction with api-phytocomposition Immune deficiency is modulated in laboratory animals by single cyclophosphan administration in a dose of 200 mg/kg of body weight (the first day of an experiment). The immune deficiency is corrected by an api-phytocomposition in the form of an aqueous suspension of honey, pollen, propolis, purple Echinacea extract in a ratio of 10:1:1:2. The composition is administered into the laboratory animal intragastrically (through a probe) in a dose of 200 mg/kg daily for 10 days on the second day of the experiment. |
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Invention relates to functional food products and represents a method for production of a non-aqueous health-improving product that is administrated in the form of drops and contains strain of lactic bacteria suspended in vegetable food oil; vegetable food oil is mixed with vitamin D; Lactobacillus rhamnosus GG lactic bacteria are suspended in the produced oil mixture. |
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Method of preparing anti-inflammatory veterinary ointment Method of preparing the anti-inflammatory veterinary ointment for outward application consists in mixing while heating to the temperature of 40-50°C in the reactor of molten petrolatum, pine oleoresin, chlorophyll-carotene paste until homogenous consistency, then glycerine and olive oil is fed portionwise with continuous stirring, after which again mixing of the components is carried out for 10-30 minutes until the homogeneous mass, the resulting ointment is cooled and packaged, at that the components of the mixture are taken in the following ratio, wt %: pine oleoresin 3.0; chlorophyll-carotene paste 3.0; petrolatum 69.0; glycerine 5.0; olive oil 20.0. |
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Method of combination treatment of chronic endometritis in cows Aminoseleton is administered subcutaneously to animals in combination with symptomatic preparations - magestrofan, uteroton, tetragidrovit and etiotropic preparation. As etiotropic preparation the combination antimicrobial agent is used containing cefotaxime, neomycin, prednisolone, emulsifier, monoglyceride, vaseline oil, in the following ratio of components, wt %: cefotaxime - 7.0%, neomycin - 1.0%, prednisolone - 0.2%, emulsifier - 3.0%, monoglyceride - 1.0%, vaseline oil to 100.0, which is administered intrauterine 2-3 times with the 24-hour intervals in a dose of 20 ml. |
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Method for making dermal matrix Method involves skin sampling from a dead donor in an operating room with using a skin grafting knife according to the standard procedure in compliance with aseptic and antiseptic regulations. Immediately after preparation, the biological material is placed in a sterile container with an aqueous solution of broad-spectrum antibiotic. The container is hermetically sealed keeping them sterile. The biomaterial is stored at -40°C until the donor's pathoanatomical findings have been obtained, and biological safety of the donor's tissues has been studied. The biomaterial with the proved biological safety is used for preparing the DM. Preparing the DM involves the following stages: separating the epidermis and the derma, conducting decellularisation of the derma, providing biocompatibility of the graft. |
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Combined bone allograft and method for preparing it What is described is a combined bone allograft representing a non-demineralised bone block prepared of a donor's spongy bone and containing human type I collagen in the form of a fine-cellular sponge prepared by lyophilisation of the bone block impregnated with a collagen solution, throughout the bone block. What is described is a method for preparing the combined bone allograft providing preparing the non-demineralised bone block of the donor's spongy bone, impregnating the bone block with the human type I collagen solution and conducting lyophilisation under the conditions providing the collagen solution transformation into the fine-cellular sponge throughout the bone block. |
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Method for preparing sports supplements Invention enables creating complex formulations of functional sports supplements of single foods with the specified concentrations of vitamins and mineral substances for sportsmen of various sports. |
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Bacterial strain lactobacillus acidophilus used to prepare fermented milk product Strain Lactobacillus acidophilus No. 9-PS has biochemical activity and high acidity. The strain is deposited in the Departmental collection of beneficial microorganisms for agricultural purposes of Russian Agricultural Academy (RCAM) under the registration number of RCAM01850. The strain may find application in prevention and correction of disorders of microbiocenosis of the gastrointestinal tract. |
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Invention relates to the pharmaceutical industry, namely to a pharmaceutical composition for treatment of a diabetic ulcer. Application of the pharmaceutical composition in manufacturing a pharmaceutical preparation in the area ofan extremity or on a body surface, or in manufacturing a dressing material for treatment of the diabetic ulcer, where the pharmaceutical composition consists of an edible bee wax, prepared on the basis of the sesame oil extract of rhizome of Scutellaria - Huangqin (Huang Qin), rhizome of Coptis - Huanglian (Huang Lian), bark of Phellodendron- Huangbai (Huang Bai), earthworm and poppy capsule, taken in a specified ratio. The dressing material for treatment of the diabetic ulcer in the area of the extremity or on the body surface, where the said dressing material contains the pharmaceutical composition, consisting of: edible bee wax, prepared on the basis of sesame oil extract of rhizome of Scutellaria - Huangqin (Huang Qin), rhizome of Coptis - Huanglian (Huang Lian), bark of Phellodendron- Huangbai (Huang Bai), earthworm and poppy capsule, taken in a specified ratio. The first aid kit for treatment of the diabetic ulcer in the area of the extremity or on the body surface. |
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Halogenated hydrocarbonate chloride sodium, alkaline, boron, high-magnesium, iodine and fluorine natural mineral water 'Lazarevskaya Tselebnaya' No. 84-E of the Volkonskoye deposit in Sochi is taken according to the following procedure: 18-20 minutes before meals in small sips, 6 times a day daily in a dose of 180-200 ml at t=24-25°C for 40 days every 3-5 days with taking the above natural halogenated mineral water in the same amounts for the following 45 days. The therapeutic course makes 3 years and repeats every 3 months. |
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Method for preservation of honey bees drone homogenate Drone larvae are separated from honeycombs. One performs pressing with subsequent adsorption of mixture of lactose and glucose into the raw product in the mixer. The prepared raw product is maintained in a sterile PET bag during 24 hours in the refrigerator. Then the raw product is arranged in a 2.0-2.5 cm layer on mylar substrates of IR-dryer screen trays; drying is performed with IR-rays during 4.0 hours at a temperature of 42-45°C in the "heating-cooling" pulse mode till production of dry crumbly clumps with moisture content equal to 10-13%. Irradiation time amounting to 5-7 sec corresponds to the "heating-cooling" pulse mode. The radiation source is represented by KGT lamps with IR radiation wavelength band equal to 1.2-2.4 mcm. |
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Method talasana-med for individual health improvement and prevention of diseases (versions) According to one version, the method involves studying the heart rate variability and a motion state, dietary nutrition, baths with mineral water, mineral water intake, physiotherapeutic procedures. The dietary regimen is specified taking into account the measured immunoglobulin IgG values to detect food intolerance and elimination thereof from the nutrition. Low-salt sulphate calcium-magnesium-sodium mineral water is taken. The baths are taken with mineral water from a water-bearing formation of Middle Devonian at a depth of 1100-1278 m by using mineral water representing a salt brine of Devonian Sea M 240-260 g/dm3 of sodium-chloride composition Cl>95, Na++K+>80 mg-eq.%, with an acid reaction of the medium, at pH 4.7-5.5. According to the other version, the method additionally contains massage sessions and acupuncture taking into account the patient's heart rate variability. |
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Method for activating myeloid tissue regeneration in old laboratory animals Method involves intravenous allogeneic transplantation of multipotent mesenchymal stromal cells recovered from the placenta in an amount of 6 mln cells/kg. Additionally, haemopoietic stem cells recovered from umbilical blood in an amount of 300 thousand cells/kg are introduced. |
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Ointment contains biologically active substances which are Apis mellifera in an amount of 21-23 wt %, St. John's wort oil in an amount of 12-14 wt %, propolis in an amount of 10-12 wt % and wax in an amount of 7-9 wt %, as well as Vaselin and lanolin as the ointment base. |
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Method of obtaining mineral silicic water Invention relates to a method of obtaining mineral silicic water (MSW), intended for application for medical purposes. The method of obtaining includes hydrolysis of tetraethoxysilane in the TEOS mixture: ethanol: water, acidified by HCl. Nanosol is obtained at a temperature of 55-65°C for 1.5 hours with evaporation of ethanol to the volume reduction by 1/3, then, dilution of the obtained nanosol with a physiological solution NaCl is carried out in 2 steps with equal portions of the physiological solution, preliminarily heated to 40-50 in a ratio of volumes of the initial nanosol: physiological solution 1:7 with 15-minute interval. After each dilution a temperature of the solution is kept in the range of 55-65°C. |
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Extracellular matrix compositions for treating cancer Group of inventions refers to medicine and can be applicable for the inhibition of tumour cell growth and proliferation. The tumour cell contacts with an extracellular matrix composition. The extracellular matrix composition is prepared by a human fibroblast cell culture on microcarrier granules in the hypoxic environment at the oxygen concentration of 1-5%. |
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Method of therapy of remittent multiple sclerosis Invention refers to medicine, namely neurology, and is applicable for treating damaged remitting multiple sclerosis. That is ensured by introducing autologous regulatory T-cells of CD4+CD25+Foxp3+ grown ex vivo at 4.5-5.5 mln cells per 1 kg of a patient's body weight in the remitting multiple sclerosis remission stage. |
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Protective coating for removable dentures Invention represents a protective coating for removable dentures differing by the fact that the coating is presented by an alcoholic amber varnish. |
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Method of treating chronic inflammatory diseases accompanied by immune deficiencies Invention refers to medicine and can be used in treating chronic inflammatory diseases accompanied by immune deficiencies. To do this, having a clinical-ambulatory immune deficiency stated, the therapeutic stage of a primary disease is followed by introducing to a patient of one-group fresh umbilical blood in an amount of three millilitres mixed with one gram of a broad-spectrum antibiotic, and one millilitre of a local anaesthetic. The above is injected three times into an infrascapular region every two days. |
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Composition for cell-replacement therapy of soft tissue defects Composition is proposed which comprises stem cells of human amniotic fluid with the phenotype CD73+/CD90+/CD105+/CK19+, nutrient medium, erythropoietin, epidermal growth factor, and collagen taken in an effective amount. |
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Method of assessment of activity of therapeutic and prophylactic preparations against natural smallpox comprises administering to an animal model of control and test groups in a predetermined scheme of suspension of the antiviral preparation under study, their intranasal infection with a strain of natural smallpox virus, incubation of the virus in animal bodies and determining the concentration of virus in the lungs of animals with the subsequent calculation of estimate values of decrease in the concentration of virus in lungs. The preparation is administered to animal bodies one day prior to infecting, on the day of infecting and every day during the time of the virus incubation. The animal models are used as outbred white mice ICR of different sexes weighing 7-9 g. The strain of natural smallpox virus is used as the strain India-3a deposited at the National Collection of pathogens of viral infections and rickettsioses of the Federal budget institution of science State Research Centre of Virology and Biotechnology "Vector" under the registration number V-45. |
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Method of treating chronic endometritis Invention relates to medicine, namely to gynaecology, reflexotherapy and pelotherapy. A method includes carrying out a course of antibacterial and/or antiviral therapy, which is started on 5-7 day of a menstrual cycle. From 5-7 day of the following menstrual cycle a course of pharmacopuncture is performed by introduction of homeopathic preparations into acupuncture points (AP). On 1, 3, 5, 7, 9, 11 and 13 days of the course Traumel C is introduced into points E36 (2), V31 (2), V32 (2), V33 (2), V34 (2). On 2, 4, 6, 8, 10, 12, 14 days of the course Ovarium compositum is introduced in AP Rp6 (2). Simultaneously with the course of pharmacopuncture or starting from 5-7 day of the following menstrual cycle a course of pelotherapy is carried out. Introduction of gel, based on the Dead Sea mud, is performed rectally for 30 minutes, 1 time per day. |
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Invention relates to industrial microbiology, namely to a method of obtaining a composition, intended for prevention of a cow milk protein allergy (CMPA) and a higher sensitivity to allergens in newborn babies and infants. The method includes a stage of milk substrate bioconversion by means of a culture of Bifidobacterium breve BBC50 strain, deposited on May 31 1999 in the National Collection of Cultures of Microorganisms (CNCM) under the number I-2219, by keeping a substrate in contact with the strain culture under conditions unfavourable for production of an acid by the strain. |
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Invention relates to the pharmaceutical industry, namely to a personal preparation from earthworms for treatment of diabetes. The method of obtaining the personal preparation from earthworms for treatment of diabetes includes placement of sexually mature earthworms in a medium, consisting of organics, which additionally contains a solution of a patient's urine, after that, the sexually mature earthworms are removed and for 3 months each 7-10 days fresh organic food is added to the remaining mass, after that, the sexually mature earthworms are separated, placed in a reservoir and sprayed with an alcohol solution, mixed, poured with the alcohol solution and placed into dark place under the specified temperature, with the solution being mixed daily, with further separation of the extract from the sediment. The personal preparation for treatment of diabetes. |
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Agent for treating mastitis in cows and method for using it Group of inventions refers to veterinary science and is applicable for treating mastitis in cows. The declared agent contains veterinary Vivaton - 10%, ASD-2 - 4%, Bursanatal - 6% and 0.9% normal saline up to 100%. The method involves administering the declared agent with underlying general strengthening and stimulating therapy. The agent is intra-cisternal into an involved one-quarter of a dug in a dose of 5 ml daily once a day using a syringe in number of 3-5 procedures. |
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Agent for stimulating substantia Nissl synthesis in spinal cord motor neurons and spinal cord motor neuronal process growth, and a method for stimulating substantia Nissl synthesis in spinal cord motor neurons and spinal cord motor neuronal process growth. The agent represents a swine or foetal adrenal cortical alcohol extract which contains natural corticosteroids in the minor concentrations. The adrenal cortical alcohol extract of swine or foetal animal cells is prepared on the basis of organ preparations. |
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Prevention and treatment of allergic diarrhoea Invention relates to the pharmaceutical industry and represents application of a composition, containing Bifidobacterium breve CNCM I-3865 (NCC2950) for preparation of a composition for prevention of allergic diarrhoea. |
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Method of industrial production of fibrin-monomer from blood plasma Invention relates to the pharmaceutical industry, namely to a method of industrial production of fibrin-monomer from the blood plasma. The method of industrial production of fibrin-monomer from the blood plasma consists in defrosting fresh frozen human plasma with continuous mixing, with further addition into plasma of a saturated ammonium sulphate solution, the obtained mixture is kept at a temperature, after which it is centrifuged, a supernatant liquid is poured out; after that, urea is dissolved in a phosphate buffer and heated, with further dissolution in the buffer of the earlier obtained fibrinogen sediment, then, human thrombin is added and mixed; the mixture is kept at a room temperature, further, the obtained mixture is divided into three parts, the phosphate buffer is introduced into a reservoir with one of the three parts of the initial fibrinogen solution, a fibrin clot, formed in the reservoir is collected, washed in distilled water and pressed, as a result, three washed fibrin clots are obtained, after that, washing of the fibrin clot is repeated two more times in the same way, the final product - fibrin-monomer is obtained by dissolution of the washed fibrin clot in an acetate buffer with urea, the obtained fibrin-monomer is poured into flasks, after that, flasks with fibrin-monomer are frozen and freeze-dried under specified conditions. |
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Halogen-containing hydrocarbonate chloride sodium, alkaline, boron high-magnesium, iodine and fluorine natural mineral water 'Lazarevskaya Tselebnaya' No. 84-E of the Volokonskoye deposite in Sochi is taken according to the following procedure: 30-35 minutes before meals in small sips, six times a day daily in a dose of 200-250 ml at t°=(23-24)°C, for 45 days every 2-3 days with taking the above natural halogen-containing mineral water in the same volumes for the following 45 days. The therapeutic course makes 3 years. |
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Group of inventions relates to biotechnology. The strain Bifidobacterium lactis CNCM I-3446 is applicable in preparing a probiotic composition for stimulating development of initial bifidogenic intestinal microbiota in the children delivered by caesarean section. The strain may be used in preparing the probiotic composition for reducing a risk of further development of allergy, as well as for preventing or treating diarrhoea in these children. |
Another patent 2513290.
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