Method of treating septic wounds with using modified montmorillonite clay
SUBSTANCE: experimental wound is cleaned daily, first with normal saline (NaCl), and then coated with modified montmorillonite clay containing 0.1 to 4.35 wt % of silver. The preparation is introduced into the wound in an amount of 0.1 g per a wound of 1.5 cm in diameter.
EFFECT: higher rate of septic wound healing.
3 tbl, 3 dwg
The invention relates to the field of veterinary medicine and can be used in particular for the treatment of purulent wounds.
There is a method of treatment of purulent wounds with the use of sorbents, in particular the use of special dressing devices containing sorbents. For example, bandages Tender Wet (Germany). Tender Wet is a multilayered wound dressing comprising as sorbent polyacrylate. The sorbent before using activate ringer's solution, which for 12 hours continuously secreted into the wound. This contributes to the softening and separation areas of necrosis. Simultaneously wound exudate is absorbed by the sorbent. This exchange is due to greater affinity sorption-active layer containing protein with wound exudate, than with a saline solution, in connection with which the wound exudate displaces ringer's solution from the absorber. Dressing Tender Wet for several hours at a time irrigates the wound and removes microorganisms, tissue debris and toxins, together with the wound. Thus, the wound is washed and easy to clean. [http://www.new-info.com.ua/hartmann/hartl 01.htm]/
The disadvantage is the need for regular wetting the bandage ringer's solution, as well as the fact that it may be spontaneous bleeding.
There is a method of treatment of septic wounds according to the patent of Russian Federation №2466720, publ. 20.11.2012, where f is PS regeneration and epithelialization of the wound surface dressings, impregnated with ointment of the following composition, wt.%: silicone glycerokinase - 95,25, ciprofloxacin is 0.2, the oxytocin - 4,55. The method allows to accelerate the regenerative processes in the second and third phases of wound healing, prevent persistent infection and septic complications, shorten the treatment time. In the treatment of septic wounds, carried out in this way, complete wound healing in animals was about 16-17 days from the start of treatment.
The increasing application at the present time finding ways of treatment of purulent wounds with the use of materials containing silver ions.
Examples of treatment efficacy of silver-containing materials is given in the way of treatment with application of dressings company Urgo on the basis of lipids-colloid technology (Cellosorb NA, Cellosorb Ag, Urgotul, Urgotul S.Ag), which are headbands, created with the use of lipids-colloid technology and containing sulfadiazine [Hermelin NR. Application of dressing devices on the basis of lipids-colloid technology in local treatment of diabetic foot syndrome. Official website of the scientific-practical journal "diabetes", 2010, №3. 3/2010 3 1291. And in the article "Modern lipid-colloid dressings in treatment of trophic ulcers and nonhealing extensive wounds to the of acestei" (Dry, Dsabel, V.Vasiliev, Iagree / J. Surgeon, No. 2 // 2013), where the marked reduction in the time bandaging 4.9±0.6 minutes and the duration of inpatient treatment of patients with trophic ulcers and nonhealing extensive wounds of the extremities 7.8±3.2 days.
The closest selected for the prototype, is a method of treatment of infected wounds with natural mineral material, modified with silver, RF patent No. 2245151, publ. 27.01.2005. The method is carried out by application of a thin layer of powder containing zeolite powder Golynskogo field modified with silver, with a particle size of 17 to 20 Å. The method provides a more therapeutic effect by increasing the porosity of the zeolite and increase the area of interaction besieged in the silver surface of the wound. A complete cleansing of wounds and the beginning of the development of granulation tissue and regional epithelialization was observed for the 9th day of treatment when used to prevent contact of the wound with the environment of a special device - fixing and insulating rings.
The objective of the invention is to expand the Arsenal of methods of treatment of purulent wounds.
The technical result is to increase the speed of healing of purulent wounds through the use of modified montmorillonite-containing clay, containing from 0.1 to 4.35 mass% of silver.
The technical result is achieved by using the proposed method of treatment of purulent wounds in the experiment, including the use of natural mineral material, modified with silver, according to which the treatment of purulent wounds carried out as follows: daily pre-treated wound isotonic NaCl solution, and then on the wound surface, at a rate of 0.1 g on the wound with a diameter of 1.5 cm, make modified montmorillonite-containing clay, containing from 0.1 to 4.35 wt.% silver.
The invention is characterized by the following graphics:
Figure 1 - Graph of the dynamics of change in the number in the wound exudate in the healing process.
Figure 2 - Graph of dynamics of changes of the presence of necrotic tissue in the wound during treatment.
Figure 3 - Graph of dynamics of growth of granulation tissue in the wound during treatment.
The proposed method meets the criteria:
- "novelty", as in the prior art unknown set of features;
- "inventive step", as in the prior art unknown effect on the rate of healing of purulent wounds montmorillonite-containing clay, modified with silver ions.
Industrial applicability is confirmed by the experiments that were conducted on 40 nonlinear white Wistar rats, weighing 190-200 g
Were simulated skin and muscle wounds on the back of animals, which are then pipette introduced strains of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Proteus vulgaris and Candida albicans in fixed infecting dose of 2×108microbial bodies (by 0,5 McFarland). All rats were divided into three groups: in the treatment of the rats of the first group (I) used a modified silver montmorillonite-containing clay, containing from 0.1 to 4.35 wt.% silver, at the rate of 0.1 g on the wound with a diameter of 1.5 cm In the treatment of the rats of the second group (II) used lipidology absorption bandage Urgosorb, the third group (III) was the control. Dressing in all groups was carried out daily, pre-treating the wound surface isotonic NaCl to remove the samples deposited previously.
Throughout the experiment 1, 3, 5, 7, 10, 14, 17, 19, 21 days conducted versatile evaluation course of wound process.
Evaluation of macroscopic picture of the points presented in table 1, where 0 is the absence of exudate in the wound, 10 - maximum amount in accordance with conventional scoring from 0 to 10.
Figure 1 shows the dynamics of changes in quantities in the wound exudate in the healing process. As can be seen from table 1 and the graph in figure 1, the reduction of exudate in the wound is more in the first group of animals, where the wound was treated opredelennomu method.
|The day of the experiment||I group||Group II||Group III|
Table 2 shows that objectively wounds in the first experimental group were "cleaner" and the process of necrosis, and thus the cleansing of wounds from nonviable tissues has occurred much faster than in other groups. Figure 2 presents the corresponding table 2 the graph.
|The day of the experiment||I group||Group II||Group III|
Dynamics of growth of granulations, rich in blood vessels and young connective tissue cells developing in the healing of wounds and foci of inflammation, which multiply rapidly and replace lost tissue area, are presented in table 3, where+is the minimum amount of granulation tissue (pale, sluggish), "+++++" - granulation bright juicy, easy contact bleeding, fill in the wound, is the process of epithelialization from the wound edges.
|The day of the experiment||I group||Group II||Group III|
The data of table 3 presents the graph 3.
The resulting experiment data indicate that the rate of "purification" of purulent wounds in group I using for the treatment of montmorillonite-containing clay was 2 times faster than in the control group III and faster 1.5 times than in group II with the use of lipids-colloidal absorption dressing.
Histomorphologically picture of the course of wound process.
Morphological changes in wounds after 1 day from the moment of contamination in the two groups n is so There are intense neutrophilic infiltration by leukocytes and their fragments, as well as deposits of fibrin, edema.
On the day 3 histological picture in the main group I differs from the compare II and test III the emergence of eosinophilic leukocytes, a large number of fibroblasts, fat cells, absence of fragments of cells.
On the 5th day in the main group I, prevails granulation tissue, newly formed blood vessels, histiocytes, fibroblasts, fat cells, which cannot be said about the comparison II and test III groups, indicating the incompleteness of the exudative phase of inflammation in them.
On the 7th day in groups I and II takes place granulation tissue, which confirms the occurrence of the 2 phases of the wound healing process. In control group, along with neutrophil white cells are macrophages, mast cells, lymphocytes, indicating the completion of only 1 phase of the wound healing process.
Also were measured temperatures (thermometry) in the wound before and after the introduction of the investigated substances using electrotermometry. Reliable data on Exo - and endothermic effect of substances have been identified.
Thus, the experimental results confirm that the rate of healing of purulent wounds in group I, under the proposed method using modified montmorillon the containing clay was faster 3 times, than in the control group III and 1.5 times than in group II.
The method of treatment of purulent wounds in the experiment using montmorillonite-containing clay, modified with silver, wherein the treatment is conducted daily, and at first the wound treated with isotonic NaCl solution, and then applied a modified montmorillonite-containing clay, which contains from 0.1 to 4.35 wt.% silver, at the rate of 0.1 g on the wound with a diameter of 1.5 see
SUBSTANCE: group of inventions relates to medicine, namely to cosmetology, and can be used for treatment of skin aging. For this purpose, used is a medication, which contains a basic fibroblast growth factor (bFGF) as a single active ingredient, which is introduced intracutaneously or subcutaneously into the place of a scar or into the surrounding region, for instance, a keloid, a hypertrophic scar and a scar contracture; in addition, the medication is also intended for treatment of one or more types of skin aging, selected from the following list: skin wrinkles, sagging skin, rough skin, skin thinning and reduction of skin resilience and elasticity because of rupture of dermal tissues or reduction of functions of fibroblast cells, with skin aging being photoaging, and a value of a dose of the basic fibroblast growth factor (bFGF) constituting from 0.1 mcg to 1 mg per 1 cm2 of skin, which represents the treatment target.
EFFECT: inventions ensure significant reduction of wrinkles, improvement of the skin structure, as well as due to an increase of its turgor and an increase of the volume of the subcutaneous adipose cellular tissue.
6 cl, 4 ex, 10 dwg
SUBSTANCE: what is described is a dressing for treating skin conditions and relieving symptoms of skin conditions accompanying blood protein exudation, or for absorbing blood proteins transuding onto the skin.
EFFECT: using the dressing for clearance of waste proteins secreted onto the skin.
8 cl, 22 dwg, 7 ex
SUBSTANCE: ointment contains biologically active substances which are Apis mellifera in an amount of 21-23 wt %, St. John's wort oil in an amount of 12-14 wt %, propolis in an amount of 10-12 wt % and wax in an amount of 7-9 wt %, as well as Vaselin and lanolin as the ointment base.
EFFECT: invention accelerates cell regeneration processes considerably due to a synergetic action of the ingredients.
SUBSTANCE: method involves coating a keratoma surface with a mixture of meadow saffron tincture 1 table spoon and Phellinus tuberculosus tincture 3-4 drops. The mixture is applied once a day on the keratoma and a skin area 1.5-2.0 mm from the keratoma border. The mixture is applied by a thin brush, first with a prime layer and with a second layer after drying.
EFFECT: minimally painful keratoma removal.
SUBSTANCE: material consists of several layers: an inner layer is made from chitosan nanofibres/superfine fibres, and an outside layer are used as an electrical forming substrate and exercise the protective function. The chitosan layer is made from herbal or mixed herbal and animal chitosan and can contain antibiotic. The multilayer material can contain at least one more layer of biopolymer nanofibres/superfine fibres electroformed of cellulose diacetate or gelatin. The three-layer material with the chitosan layer of the nanofibres/superfine fibres is applicable for local wound and burn healing.
EFFECT: material resistance to mechanical stress.
15 cl, 4 dwg, 8 ex
SUBSTANCE: invention refers to medicine, namely dermatology and may be used for stimulating repair of wounds of various geneses. For this purpose, wound cleansing is followed by daily dressings with dihydroquercetin powder applied on a wound surface at the bacterial content no more than 103-4 m.c. per 1 cm2 as a layer of 1-2 mm until wound self-epithelisation, before or after autodermoplasty with a free split-skin flap. That is combined with prescribing the biologically active additive Laviocard+ orally 1 capsule 2 times a day with food for 21 day.
EFFECT: method provides correcting abnormal lipid peroxidation and activating antioxidant protection in local and systemic homeostasis by stimulating and reducing a repair length.
2 ex, 6 tbl
SUBSTANCE: invention can be used for treating degree III-IV radiation injuries on radiation fields following neutron therapy in patients suffering from local recurrent breast cancer (BC). That is ensured by wound irrigation with ozonised distilled water with ozone concentration of 10,000 mcg/l; a skin ulcerous defect is processed in a vacuum container for 10-15 minutes with gaseous ozone with the concentration of 10,000 mcg/l. That is followed by ozonised air applications with the parameters of: peroxide number - 18%, acid number - 71 mg CFU/g on the skin ulcerous defect once or twice a day for 10-15 days every 5-7 days for 2-3 courses.
EFFECT: ulcer detersion from purulent deposits, active regeneration and the skin ulcerous defect healing.
6 dwg, 2 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: group of inventions refers to medicine and may be used for treating an individual suffering from a persistent, sluggish, partially healing, open or chronic wound. That is ensured by administering anti-connexin 43 polynucleotide approximately 0.001 to approximately 1 mg/kg of body weight into the wound of the individual in a pharmaceutically acceptable carrier. Stimulating and improving wound healing, improving wound healing rate in a diabetic patient and an individual suffering from a chronic skin wound is also suggested. Kits and finished products containing Pluronic F-127 and anti-connexin 43 polynucleotide presented by SEQ ID NO: 1 for wound healing.
EFFECT: group of inventions provides wound healing, relieved inflammation within the persistent wound, as well as minimised cicatrisation.
129 cl, 4 dwg, 3 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: there are presented: using a compound of formula (1) or its salt for preparing a drug for increasing HIF-1α stabilisation in a cell, as well as for preparing a drug enhancing the immune response in an individual, for preventive management of a wound to avoid an infection, for treatment of the microbial infection, for improvement of efficacy of a vaccine for management of the wound in the individual. What is presented is a pharmaceutical composition containing the above HIF-1α prolyl hydroxylase inhibitor and one or more additives. What is shown is achieving the declared applications by using the new compound of formula (1) with the HIF-1α prolyl hydroxylase (HIFPH2 (EGLN1)) inhibitor. It makes it applicable for treating HIF-1 alpha activity related diseases, conditions and/or syndromes.
EFFECT: preparing the drug for increasing HIF-1α stabilisation in a cell.
26 cl, 20 dwg, 8 tbl, 13 ex
SUBSTANCE: invention refers to the veterinary science, particularly to substances used in treating purulent-necrotic involvements of bovine's distal extremities, including digital dermatitis. A preparation for treating bovine digital dermatitis in the form of an ointment consists of an excipient, containing an ointment base, and an active ingredient - zinc oxide and copper sulphate in the following proportions, wt %: zinc oxide 9-11, copper sulphate 35-45, the ointment base - the rest.
EFFECT: invention provides higher clinical effectiveness with cost cutting for the ointment preparation.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine. A kit for treating diseases requiring the topical application of therapeutic agents comprises a case accommodating a therapeutic agent container containing the liquid therapeutic agent in an amount sufficient for multiple application, several applicators the number of which is equal to the number of applications of the therapeutic agent; each applicator is completely made of a material possessing the properties of flexibility, elasticity and non-absorbent the therapeutic agent, comprises an integral handle and a flat blade coupled by a flexible pin with a depth of section being less than those of the handle and the blade so that the flat blade deviates when in use, and a mirror inside the case.
EFFECT: eliminating a risk of recurrent or cross contamination.
13 cl, 3 dwg
SUBSTANCE: method involves a combination of peloid applications and ultrasonic exposure. Peloid is applied on anterolateral thighs and an anterior abdominal wall. The applications are alternated every second day. Peloid is silt sulphide mud of Melkovodnenskiy deposit. The mud is applied in layer 10 mm thick at temperature 34-36°C. The applications are exposed to ultrasound at frequency 880 kHz in a continuous mode. The applications of the anterior abdominal wall are exposed to ultrasound at intensity 0.2-0.4 Wt/cm2 for 5 - 10 minutes. The anterolateral thighs are exposed to ultrasound at intensity 0.4-0.6 Wt/cm2, for 6-8 minutes for each thigh. Upon the completion of the procedure, the patient is covered with a hydrophobic tissue and left for 10 minutes. The therapeutic course is 10 procedures.
EFFECT: reducing obesity effectively by exposing on the hormonal activity of fat tissue, maintains the results obtained within three months.
SUBSTANCE: invention refers to medicine, namely rheumatology, balneotherapy and physiotherapy. The method involves the integrated treatment. There are prescribed sulphide bath with the total hydrogen sulphide concentration of 158 mg/l, the free hydrogen sulphide concentration of 108 mg/l at temperature 36-37°C. The length of the first 2-3 baths is 6-8 minutes. The length is to be increased to 8-12 minutes. The baths are taken within the period of 10.00 to 12.00 every second day. The therapeutic course is 10-12 procedures. On the same days, within the period of 14.00 to 16.00, therapeutic exercises are done, and the climatic and landscape therapy is prescribed. On the days free from taking baths, within the period of 10.00 to 12.00, the EHF therapy is prescribed to cover biologically active points (BAP) at frequency 40-43 GHz. The points G-41, 3E-5 are exposed. The hip osteoarthrosis requires the exposure on the points G-29, G-30. If observing the upper extremity osteoarthrosis, the points 3E-4, Du-4, Du-5, Di-5 are covered. In case of the knee osteoarthrosis, the points M-34, M-35, Le-7, Le-8 are exposed. The length of the exposure covering one BAP makes 5-6 minutes. The total length of the procedure is 20-30 minutes. On the same days within the period of 14.00 to 16.00, high-mineralised average sulphide mud is applied at temperature 38-40°C on the involved joints and respective spinal reflexogenic zones. A single procedure covers not more than 2-3 greater joints. The length of one procedure is 20-25 minutes. The therapeutic course is 8-10 procedures. The total length of the rehabilitation makes 20-24 days.
EFFECT: method prolongs the remission.
2 tbl, 1 dwg, 1 ex
SUBSTANCE: invention refers to medicine, namely to - arthrology, physiotherapy, balneology. The method involves physical methods of therapy, therapeutic exercises, massage, acupuncture and phytotherapy. The patients are trained to give a self-massage of the knee joints additionally during the resort therapy and after the termination of the rehabilitation. From the 1st to 10th day of the therapeutic course patient's knee joint is exposed to polychromatic polarised light at 20 cm for 6 minutes. The patients take 10 iodine-bromine baths at temperature 37°C for 10 minutes. From the 1st to 5th therapeutic days, the patients do combined therapeutic exercises; their lower extremities are massaged manually for 10 minutes. From the 6th to 15th days, the knee joints are exposed to sinusoid modulated currents (SMC) at modulation frequency 100 Hz, at a depth of 50 - 70%, current intensity to moderate vibration for 7 minutes. From the 6th to 10th days, the braking acupuncture follows by giving a 1-2-minute massage of the points 10RP, 9RP, 36E, 34E by introducing a needle for 30 seconds and by giving a point massage of cheng-fu, cuan, yang-lin-cuan, zu-sang-li, wei-yang, cheng-shan, chung-feng, hun-lun, nei-ting. The patients take a herbal infusion. From the 11th to 15th days, the knee joints are exposed to decimetric waves (DMW). That is followed by a hydro-massage of the lower extremities and lumbar region for 15 minutes up to 3 atm. Thereafter, the 10-minute post-isometric relaxation of the quadriceps muscle of thigh is applied. The patients do the complex of weight reduction exercises and take the herbal infusion. From the 16th to 20th day, the mud applications on the knee joints are prescribed at temperature 42°C for 30 minutes. If suffering gonarthrosis, the patients do the complex of therapeutic exercises. That is followed by the paravertebral vacuum therapy of the vertebral column. The 10-minute knee joint traction is applied. The patients take 20 g of the herbal infusion.
EFFECT: method recovers the joint mobility, improves the exercise tolerance of the lower extremities.
1 tbl, 2 ex
SUBSTANCE: invention relates to field of medicine, namely to dentistry, physiotherapy. Method includes influence by defocused shock wave through applications of enterosorbent "BS-P", applied on upper and lower jaw. Influence by shock wave is realised through soft tissues of maxillofacial area. Influence is performed with pulse duration 0.4-0.7 mcs, pulse frequency 90 Hz, pressure amplitude from 6 to 9 MPa, total number of pulses 1000. Procedures are carried out every second day. Course includes 7-10 sessions.
EFFECT: method enhances reparative processes due to correction of disorders of microcirculation and metabolism stimulation.
SUBSTANCE: invention refers to medicine, specifically to physiotherapy, surgery. A method consists in conducting a course of pelotherapy by applications. The therapy is started within the first four weeks following a laparotomy. The therapy involves the sulphide mud applications on an anteriolateral abdominal wall. The sulphide mud temperature is 42° C. The application length is gradually increased from 10 to 20 minutes. The procedures are performed every second day. A minimum number of the applications is 10.
EFFECT: method reduces the peritoneal adhesions.
FIELD: personal use articles.
SUBSTANCE: invention relates to cutting devices and may be used for hair clipping. The device contains a body with guides positioned on its bottom, a blade, a disk and a brush. The brush covers the blade and is installed in the body guides to that to enable reciprocating motion. The reciprocating motion is ensured with the help of the disk by way of mechanical frictional transmission.
EFFECT: ensuring the possibility of sparing mode preparation of hair cores within damaged areas of skin integuments for performance of medical manipulations.
SUBSTANCE: invention relates to medicine, namely to methods of treating diseases of various aetiologies and injuries of various visceras. Electropunctural pre-examination aims at determining the patient's overall potential and the potential in a point on the body surface at a minimal distance from the viscera to be treated, or in its immediate projection tender zones. A stem cell growth area is stimulated by placing a bee within the sternum. Then, an irritation centre is created using vacuum- or hirudotherapy in a point on the body surface at a minimal distance from the above viscera or in its immediate projection tender zones. The irritation centre is created to be intensive and short-term at the level of the potential in the point below the overall potential, or to be weak and long-term at the level of the potential in a point above the overall potential.
EFFECT: method provides the effective local therapeutic effect on the involved visceral tissues ensured by a combination of the used components of the effect.
2 cl, 3 ex
SUBSTANCE: invention refers to medicine, namely to - physiotherapy, balneology. A method involves the exposure to a low-frequency pulse magnetic field. The exposure covers 6 fields. If the exposure covers the 1st and 2nd fields, including paravertebral muscles, the mode B is used. The exposure consists of single pulses of the pulse duration for S inductor 110±10 mcs, for N inductor 260±20 mcs. Pulse length is 16 Hz, and intensity is 70-80%. The inactive N inductor is placed on the side of more evident pain sensations. Length of the exposure is 3 minutes. If the exposure covers the 3rd-6th fields including projections of the gluteus medius muscle and rectus muscle of thigh, the mode A is used. The exposure consists of paired pulses. The pulse duration for S inductor is 110±10 mcs, and for N inductor 260±20 mcs. Intensity is 80-100%. An inter-pulse interval is 40 ms. The active S inductor is placed within a projection of the gluteus medius muscle and rectus muscle of thigh in its lower one-third from the side of the surgically operated joint. The inactive N inductor is placed on a posterior thigh in its lower one-third and a projection of the rectus muscle of thigh in its upper one-third. The exposure length for the 3rd-4th and 5-6th fields makes 3 minutes for each. Total duration of a procedure is 9 minutes. The procedures are daily. The therapeutic course is 10-12 procedures. Pelotherapy by applications of peat mud onto the paravertebral lumbar spine and a projection of hip joints follows 60-90 minutes later. Mud temperature is 38 - 40°C. Duration of a procedure is 20-30 minutes. The procedures are performed every second day. The therapeutic course is 8-10 procedures. The method improves body self-adaptation ensured by optimising the immune system functioning, the lipid peroxidation system and antioxidant protection.
EFFECT: method activates the metabolic processes in joint and periarticular tissues ensured by normalising micro blood flow in the lower extremities.
2 ex, 5 tbl
SUBSTANCE: invention relates to medical equipment. An infected wound healing apparatus comprises a closed fluid container and a fluid outflow tube (5). The container is connected with an air pump element (23) through a tube and provided with a fluid supply hose (4). The container is multi-chamber, and each chamber (16-18) is connected through an individual pipe (13-15) with a collector (11) provided with a switch (12). The fluid supply hose (4) extends from the collector into a rigid cup (1) with a lower border (2) made of a viscoelastic material. The fluid outflow tube (5) is provided with an outflow level controller (29). On the surface of the cup, there is a handle (3) tightly pressing the viscoelastic border of the cup to the surrounding skin. The cup is provided with a Velcro strap (6, 7).
EFFECT: using the invention enables the higher healing quality of the wound infected by mammal bites and reducing contamination of the surrounding environment by improving the hygiene of the therapeutic procedure.
2 cl, 3 dwg
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmaceutical industry, namely to using smectite for treating or preventing celiac disease. Using smectite known as diosmectite for preparing a therapeutic agent for treating or preventing celiac disease.
EFFECT: agent is effective in preventing and treating celiac disease.