Method of preparing anti-inflammatory veterinary ointment

FIELD: veterinary medicine.

SUBSTANCE: method of preparing the anti-inflammatory veterinary ointment for outward application consists in mixing while heating to the temperature of 40-50°C in the reactor of molten petrolatum, pine oleoresin, chlorophyll-carotene paste until homogenous consistency, then glycerine and olive oil is fed portionwise with continuous stirring, after which again mixing of the components is carried out for 10-30 minutes until the homogeneous mass, the resulting ointment is cooled and packaged, at that the components of the mixture are taken in the following ratio, wt %: pine oleoresin 3.0; chlorophyll-carotene paste 3.0; petrolatum 69.0; glycerine 5.0; olive oil 20.0.

EFFECT: improved efficacy of treatment.

2 ex

 

The invention relates to veterinary medicine, in particular to a technology for anti-inflammatory veterinary ointment for the treatment of mastitis, burns, eczema, tissue damage, and cracks.

Known methods of preparing ointments, comprising mixing the drug or biologically active substances with fatty materials [Reference Ed. I.E. Mozgova. Veterinary compounding with the basics of treatment and prevention. M VO "Agropromizdat", 1988 (1)].

Known composition of the anti-inflammatory ointment for external application "Paton, including SAP pine 19,0-21,0%, beeswax is 16.8-17.5 percent, chalk 10,5-12,0%, fat basis else [Patent RU 2097056, publ. 1997.11.27 (2)]. However, the method of its preparation is time-consuming and inefficient, the presence of chalk negative impact on the technology of preparation and application of ointment.

The aim of the invention is to develop the most effective, more efficient technology for the production of anti-inflammatory veterinary ointment that can improve the homogeneity, the main quality of the ointment.

Method of preparation of anti-inflammatory veterinary ointment for external use is mixing while heating to a temperature of 40-50°C in the reactor melted vaseline, pine resin, chlorophylla-carotene paste until smooth, then parti the NGO serves glycerin and olive oil with constant stirring, then again carry out the mixing of the components within 10-30 minutes until smooth, then cooled and Packed, while the components of the mixture taken in the following ratio, wt.%:

The pine oleoresin3,0
Paste chlorophylla carotene3,0
Vaseline69,0
Glycerin5,0
Olive oil20,0

The oleoresin of pine gives antiseptic properties ointment, is well combined with the components. After application to the wound and drying forms an antiseptic film.

Paste the coniferous chlorophylla-carotene due to the presence in its composition of natural compounds that stimulate the healing of affected areas, and powerful antioxidants cleanse the wound of necrotic tissue, anti-inflammatory, protects against external pathogens, stimulate repair processes.

Vaseline and glycerin to give adhesion to the skin and cloth (wool, bristles and the like). Forms a protective thin layer on the surface of wounds (burns), air-permeable and resistant to the log.

Olive oil contains a complex of vitamins E and A are responsible for the hydration and elasticity of the skin; B, D, K, and monounsaturated fats affect the improvement of the skin and promote the regeneration of skin cells and give the oil its healing effect.

Anti-inflammatory veterinary ointment is a homogeneous mass of light yellow color with a smell of pine needles. When applied to the skin ointment penetrates through the sebaceous glands and partially through the intercellular passages, where the transition in a soluble state and gradually absorbed, helping to expand the vessels, improve blood circulation and accelerate the resorption of hematomas.

Veterinary ointment used to treat farm animals with mastitis, wounds, burns, traumatic tissue damage, eczema, dermatitis, bursitis, contusions, when the warts and sores on the nipple of the udder.

The ointment is applied in a thin layer on a clean white cloth or gauze, which cover the affected area of the body, and then strengthen the bandage or special glue. When injuries, mastitis impose warming bandage.

Example 1. In a reactor equipped with a jacket and a stirrer, serves 13,8 kg vaseline, melt it and add 0.6 kg of oleoresin of pine, pre-cleaned from mechanical impurities and water, 0.6 kg of pasta, chlorophylla-carotene is howling. The ingredients are heated to a temperature of 40-50°C, mix until smooth, then slowly serves 1.0 kg of glycerin and 4.0 kg of olive oil. After downloading all of the ingredients the mixture is stirred until a homogeneous state for 10-30 minutes. The resulting ointment is cooled and Packed.

Example 2. In a reactor equipped with a jacket and a stirrer, serves 13,8 kg vaseline, melt it and add 0.6 kg of oleoresin of pine, pre-cleaned from mechanical impurities and water, 0.6 kg of pasta, chlorophylla-carotene. The ingredients are heated to a temperature of 40-50°C, mix until smooth, then slowly serves 1.0 kg of glycerin and 4.0 kg of olive oil. After downloading all of the ingredients the mixture is stirred until a homogeneous state within 10-40 minutes. The resulting ointment is cooled and Packed.

The study veterinary ointment at the Department of veterinary pathology Agricultural Institute FGBOU VPO "Mordovian state University. N.P. Ogarev", Saransk, preliminary results have been positive. Experiments on the treatment of wounds with ointments on the basis of the proposed structure showed the following results: different animals clinical signs of the disease are expressed in varying degrees, because of the nature of the wound microflora and reaction scenariothe. The boundaries of the separate tissues and anatomical structure masked by fibrin, mixed with the remnants of blood. By 5-7 days in some areas, free from blood clots, appeared pink-red nodules the size of a millet seed, which do not bleed, had a granular appearance, fairly thick consistency, noted the presence of small amounts of gray-white exudate. By that time, was the demarcation of viable tissue, which are then rejected and were visualized in the wound. The amount of discharge from the wound quickly dwindled, became serous. Application of ointments on the basis of the oleoresin of pine improved biochemical parameters in experimental laboratory animals, by the 12th day there was a trend toward normalization of metabolic processes.

Studies have shown that the application of ointments on the basis of the proposed structure provides optimum flow conditions of metabolic processes in tissues by affecting local microcirculation, stimulation of reparative processes in the wound and prevention of secondary infection of wounds, especially microorganisms with polyresistance to modern antiseptical.

Sources of information

1. Handbook Ed. I.E. Mozgova. Veterinary compounding with the basics of treatment and prevention. M: Agropromizdat, 1988.

2. Patent RU 2097056, SDA is L. 1997.11.27, prototype.

Method of preparation of anti-inflammatory veterinary ointment for external use, which consists in mixing while heating to a temperature of 40-50°C in the reactor melted vaseline, pine resin, chlorophylla-carotene paste until smooth, then portions served glycerin and olive oil with constant stirring, then again carry out the mixing of the components within 10-30 minutes until a homogeneous mass is obtained ointment cooled and Packed, while the components of the mixture taken in the following ratio, wt.%:

The pine oleoresin3,0
Paste chlorophylla carotene3,0
Vaseline69,0
Glycerin5,0
Olive oil20,0



 

Same patents:

FIELD: medicine.

SUBSTANCE: drug preparation for treating tuberculosis contains an active substance isoniaside, and a pharmaceutical carrier tiozol gel with the isoniaside concentration of 5.7-54.5 wt % and the tiozol gel concentration of 45.5-94.3 wt %.

EFFECT: higher clinical effectiveness in tuberculosis and lower toxicity.

2 cl, 2 tbl

Burn ointment // 2523551

FIELD: medicine.

SUBSTANCE: ointment contains biologically active substances which are Apis mellifera in an amount of 21-23 wt %, St. John's wort oil in an amount of 12-14 wt %, propolis in an amount of 10-12 wt % and wax in an amount of 7-9 wt %, as well as Vaselin and lanolin as the ointment base.

EFFECT: invention accelerates cell regeneration processes considerably due to a synergetic action of the ingredients.

7 ex

FIELD: medicine.

SUBSTANCE: pharmaceutical composition can additionally contain ethylenediaminotetraacetic acid, polyvinyl pyrrolidone, polyvinyl alcohol, a preserving agent specified in a group: Nipagin, Nipasol, benzoic acid, sodium benzoate, sorbic acid, benzalkonium chloride. As a body-forming base, the composition can contain distilled water, polyethylene oxide 400, polyethylene oxide 4000, polyethylene glycol, propylene glycol, a phosphate buffer, a borate buffer, an acetate-borate buffer depending on a dosage form.

EFFECT: high therapeutic effectiveness, prolonged corneal contact of the preparation which reduces the number of instillations, avoids a risk of side effects and provides good tolerance.

5 cl, 5 ex

FIELD: medicine.

SUBSTANCE: invention refers to the veterinary science and is applicable for treating bovine digital dermatitis. A method involves applying a preparation in the form of an ointment of the following formulation, wt %: veterinary copper sulphate 35-45, zinc oxide 9-11, an ointment base - the rest. The preparation is made by mixing the ingredients until smooth. The preparation is applied on the involved regions 1-2 times with or without a protective dressing.

EFFECT: method is effective in treating bovine digital dermatitis.

1 tbl, 1 ex

FIELD: medicine.

SUBSTANCE: topical gel composition for treating erythema or a related symptom contains brimonidine 0.4 wt % to 0.6 wt %, preferentially in the form of brimonidine tartrate, a gelatinising agent, and at least one polyol. The topical application of the gel composition on the skin involved in erythema or having a manifestation of the related symptom has an effect on a serum or plasma profile of brimonidine with an average Cmax approximately 54±28 pcg/ml or less and an average AUC0-24h approximately 568±277 pcg·h/ml or less.

EFFECT: safe and effective treatment of erythema causing no inadequate drug-related side effects.

19 cl, 3 dwg, 5 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: invention refers to a composition containing encapsulated triterpenic acid: betulinic acid, ursolic acid or derivatives thereof in the form of salts and esters, or triterpene alcohol - betulin, which may be used in medicine for treating and preventing viral infections caused by DNA and RNA-containing viruses, such as influenza viruses, oncogenic viruses, herpes virus, herpes zoster virus, as well as infections caused by gram-positive and gram-negative bacteria: Staphylococcus spp., Streptococcus spp., Enterococcus spp., Shigella spp., Escherichia spp., Salmonella spp., Proteus spp., Acinetobacter spp., Citrobacter spp., Pseudomonas spp., Serratia spp., Klebsiella spp., Antracoides spp., Cryptococcus spp., pathogenic fungi of the genus Microsporum, Trichophyton, Nocardia, Aspergillus, yeast-like fungi of the genus Candida, including multiresistant strains, as well as Actinomycetes and some pathogenic protozoa: Entamoeba histolytica, Trichomonas vaginalis. The invention presents the composition containing an active ingredient presented by 0.5 wt % of betulin or 0.5 wt % of encapsulated triterpenic acid: betulinic acid, ursolic acid or derivatives thereof in the form of salts and esters and others, and carriers presented by: β-cyclodextrins, fullerene, lecithins and polymers binding to the ingredients to form ingredient-carrier complexes, and excipients.

EFFECT: higher efficacy of using the composition.

3 cl

Wound-healing drug // 2517065

FIELD: chemistry.

SUBSTANCE: invention relates to a wound-healing drug which consists of stearic acid; castor oil; zinc stearate; 70% alcohol extract of a plant collection including oak tree bark, marigold flowers, wild chamomile flowers, nettle leaves, taken in ratio of 1:3:2:1, respectively; Na salts of fatty acids of wool fat; boric acid; vaseline; glycerine; triethanolamine; treated water; vegetable oil; Tipton weed extract; wild rose oil or sea buckthorn oil; 10% propolis oily solution; natural L-amino acid-peptide biocomplex obtained by extracting native paunch manure of ruminants with 2.0-3.0% NaCl solution; purified lanolin and derivatives thereof.

EFFECT: improved bactericidal, anti-inflammatory, regenerating, antioxidant and antimicrobial properties, drug does not have allergic action.

4 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, namely to an agent for treating an oral mucosal involvement accompanying lichen acuminatus. An adhesive ointment for treating the oral mucosal involvements accompanying lichen acuminatus containing sea buckthorn oil and 0.5% prednisolone ointment, socoseryl dental adhesive paste and vitamin A in the specific proportions.

EFFECT: ointment is effective for treating the oral mucosal involvements accompanying lichen acuminatus.

3 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, namely an agent possessing anticoagulant activity. A method for preparing a dry fucus extract possessing anticoagulant action by the complex treatment of Fucus vesiculosus. The dry fucus extract possessing anticoagulant activity representing a polysaccharide complex containing fucoidan having the following composition: neutral monosaccharides - fucose, xylose, mannose, galacose, glucose, uronic acid; as well as polyphenols and sulphates in specific amount. The anticoagulant ointment containing the dry fucus extract.

EFFECT: agents described above possess pronounced anticoagulant action.

4 cl, 4 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine, namely to pharmacy and concerns the development of an ointment containing mechanically activated amorphous or amorphous crystalline calcium gluconate, and may be used in the integrated treatment of skin diseases related to calcium deficiency, namely to the integrated treatment of dermatoses: psoriasis, atopic dermatitis, eczema and keratoderma. As an active ingredient, the ointment contains mechanically activated amorphous or amorphous crystalline calcium gluconate; an ointment base is Vaseline, glycerol, emulsifier No.1, Lutrol F 127 and purified water in the following proportions, wt %: mechanically activated amorphous or amorphous crystalline calcium gluconate-5.0; Vaselin-10.0; glycerol-10.0; emulsifier No.1-8.0; lutrol F 127-2.0 and purified water up to 100.0.

EFFECT: ointment possesses high therapeutic activity, provides the uniform release of the active ingredient that is mechanically activated amorphous or amorphous crystalline calcium gluconate, the manifested prolonged action and applicability by the patient.

4 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to the pharmaceutical industry, in particular to a peroral pharmaceutical composition, which contains polysaccharides from platyclades of Opuntia Ficus Indica, an extract of Olea Europeae leaves, alginate and sodium bicarbonate in a specified ratio. Components of the composition described above act with respect to reduction of gastroesophageal reflux.

EFFECT: peroral pharmaceutical composition is intended for the prevention and treatment of gastroesophageal reflux and GERD.

4 cl, 9 tbl, 6 dwg

FIELD: medicine.

SUBSTANCE: antimicrobial composition for coating a medical device includes a material, which forms a polymer film, and an antimicrobial preparation from the traditional Chinese medicine, selected from a group: extract of Houttuynia cordata, sodium houttuyfonat and sodium new houttuyfonat or their mixtures. The medical device, covered with an antimicrobial composition, is made in the form of an implanted device.

EFFECT: invention provides the antimicrobial effectiveness with respect to microorganisms - causative agents of surgical infections.

19 cl, 2 dwg, 7 tbl, 4 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to the field of pharmaceutics, in particular represents compositions and methods for the oral cavity care, in which a composition includes chalcone as a colour-changing component, which can represent phenyl-3-methoxy-4-hydroxystyrylketone. The change of colour of the colour-changing component is caused by an addition of saliva and/or change of the composition pH.

EFFECT: composition and methods provide a favourable impact, including provision of the user with visual keys.

13 cl, 1 dwg, 5 ex, 1 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to the pharmaceutical industry, namely to a composition for the prevention and treatment of esophageal reflux. The composition for the prevention and treatment of esophageal reflux contains a lipophilic extract of Zingiber officinale and a lipophilic extract of Echinacea angustifolia in specified weight ranges, obtained by the extraction with carbon dioxide. The application of the lipophilic extract of Zingiber officinale and the lipophilic extract of Echinacea angustifolia, taken in the specified weight ranges, for the prevention and treatment of esophageal reflux.

EFFECT: composition is effective for the prevention and treatment of esophageal reflux.

6 cl, 2 ex

FIELD: medicine.

SUBSTANCE: group of inventions relates to veterinary and medicine, in particular to obtaining and application of biopreparations for immunotherapy of ecopathologies. The group of inventions includes obtaining a protein antigen from a mixture of anatoxins from three enteropathogenic virulent strains of a pathogen of escherichiosis of calves E.coli No. 378, 379, 380 by their growing on Hottinger medium with further addition of 0.4-0.5% formalin, following thermostating for 10-12 days and cooling the mixture of anatoxins with a sterile solution of aluminium hydroxide, after that obtaining radioantigen from E.coli "PL-6" by growing cultures on a meat infusion agar with further washing away a biomass by a physiological solution and irradiation of the obtained suspension with a concentration of 1.2·1010 m.c./cm3 on a gamma-installation in a dose of 140-150 Gr with following thermostating and extraction of radiotoxin with 70% acidified with 0.05% hydrochloric acid to pH 5.5 ethanol, following evaporation of the exractant to the initial volume, after that, obtaining protein-cadmium radioantigen first by preliminary dechlorination of cadmium chloride, obtaining cadmium hydroxide, addition into the obtained 2.7% solution of the antigen of 0.77% solution of cadmium hydroxide in a ratio of 1:1 with following thermostating at a temperature of 37°C for 30 minutes, evaporation and dissolution of the residue to 12.8% concentration, further obtaining protein-cadmium radioantigen by an addition of 1.2% solution of a mixture of three anatoxins of E.coli and 12.8% solution of cadmium radioantigen in a ratio of 1:9, conjugation of components at room temperature for 8-10 hours, standardisation by a dry substance to 10% concentration and pouring into vials, and storage at a temperature of 4-6°C. The group of inventions also relates to a method of treating radiation, chemical and/or bacteriological damage to an organism by introduction of 10% solution of complex protein-cadmium radioantigen.

EFFECT: application of the group of inventions is effective in treatment of radiation, chemical and/or biological damage.

4 cl, 6 ex

FIELD: cosmetology.

SUBSTANCE: cosmetological set comprises 25-50 biodegradable meso-sutures based on polydioxanone, attached at the sharp ends of the guide-needles of high strength steel with size of 25G-31G, and 0.75-2.5 ml of the preparation on the base of the hydrolyzate of placenta, which is a Laennec and/or Curacen, and also a method of lifting the soft tissues using the above set.

EFFECT: effective skin rejuvenation and removal of soft tissue defects with aesthetic long-lasting effect in patients of different age groups.

4 cl, 3 ex

FIELD: medicine.

SUBSTANCE: invention enables creating complex formulations of functional sports supplements of single foods with the specified concentrations of vitamins and mineral substances for sportsmen of various sports.

EFFECT: recovered physiological body saturation with vitamins and mineral substances on the basis of an algorithm for determining sportsmen's body saturation with these nutrients.

4 cl

FIELD: biotechnology.

SUBSTANCE: compounds have the general formula: X1-X2-X3-Pro-X4-Pro-X5, where X1 is selected from H, Ac-, Palm-; X2 is selected from Trp, Tyr; X3 is selected from Trp, Tyr; X4 is selected from Lys, Orn, Dbu, Dpr, Arg; X5 is selected from-OH, -NH2, -OCH3, -OC2H5, -NH-C6H5. This compound can be represented in the form of retroisomer.

EFFECT: invention enables to block selectively the muscle nicotinic acetylcholine receptor with high efficiency.

12 cl, 7 dwg, 1 tbl, 5 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to the field of pharmaceutics. An extract of Fraxinus excelsior seeds, capable of activating PPAR-alpha, which contains nuzhenide GI3, oleoside methyl ester, excelside B, GI5, salidroside, in effective quantities. An application of the extract of Fraxinus excelsior seeds to obtain a medication for treating a state, in which the PPAR-alpha activation is useful, is described. Also described is a method of treating a subject with the state, in which the PPAR-alpha activation is useful. A method of obtaining the extract of Fraxinus excelsior seeds is disclosed.

EFFECT: application of the claimed extract makes it possible to treat states, in which the PPAR-alpha activation is useful in an efficient way.

14 cl, 11 dwg, 2 tbl, 13 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions relates to a composition for teeth cleaning and a method of its obtaining. The claimed composition for teeth cleaning contains in one phase an orally acceptable carrier; a source of fluorine ions; a source of bivalent tin ions; a source of zinc ions and, at least, one polyphosphate salt, selected from a group, which consists of inorganic polyphosphates, which have 3 or fewer atoms of phosphorus; and the general content of water in the composition for teeth cleaning constitutes less than approximately 10% of the composition mass. The method of obtaining the claimed composition includes mixing the source of bivalent tin ions with a water buffer system, adapted for chelation of bivalent tin ions in a premix, formed in this way; and combining the premix with the active components and the orally acceptable carrier.

EFFECT: combination of sources of bivalent tin, fluorine, zinc and the upper mentioned polyphosphate with a low content of water makes it possible to obtain the composition for teeth cleaning in the form of a one-phase system, which provides a possibility of an effective delivery of unstable in water active ingredients, which begin a reaction with each other in one phase.

28 cl, 2 dwg, 3 tbl, 5 ex

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine. Course of chemotherapy with intravenous drop introduction of 100 mg/m2 of cisplatin, doxorubicin - 30 mg/m2 and vincristine - 4 mg/m2 is carried out. After distant gamma-therapy with bringing onto initial focus and regional lymph nodes of total dose 20 Gy, 11-12 sessions of intracavitary Co therapy by two fractions in 2.5 Gy with 5-hour interval, with rhythm 2 times per week alternating with distant gamma-therapy on regional lymph nodes and weekly intravenous introduction of 250 mg of 5-fluorofuracyl at all stages of irradiation.

EFFECT: application of claimed method makes it possible to increase single and total focus doses in intracavitary irradiation, improve results of combined radiotherapy, reduce reactions to normal tissues of adjacent organs and improve life quality of patients with cancer of said localisation in the process of treatment.

1 ex

Up!