Method for radioactive substance washout from biological tissue with natural halogen-containing mineral water

FIELD: medicine.

SUBSTANCE: halogen-containing hydrocarbonate chloride sodium, alkaline, boron high-magnesium, iodine and fluorine natural mineral water 'Lazarevskaya Tselebnaya' No. 84-E of the Volokonskoye deposite in Sochi is taken according to the following procedure: 30-35 minutes before meals in small sips, six times a day daily in a dose of 200-250 ml at t°=(23-24)°C, for 45 days every 2-3 days with taking the above natural halogen-containing mineral water in the same volumes for the following 45 days. The therapeutic course makes 3 years.

EFFECT: method enables improving the health status in the individuals subject to the hazardous effect of radionuclides taken with water or food.

2 cl, 6 tbl, 3 ex

 

The technical field

The invention relates to medicine, in particular to a system of therapeutic and preventive measures aimed at accelerating the excretion of biological tissues of animals and human body of radioactive substances.

The level of technology

The problem of removing radioactive substances from the external environment and living organisms rather actively discussed in the scientific literature since the late 40-ies of the last century. In particular, in 1980, published by Atomizdat" (USSR) came Methodical recommendations on sanitary control over the content of radioactive substances in AN external environment. Seas, A.S. Zykova, 1980 [Annex 1, § 11], where it was systematically described the role of radioprotectors that protect the body from external radioactive contamination. At the same time, the guidelines No. 5779-91 [Annex 1, item 1] the Ministry of health of the former USSR indicated the feasibility of using effective radioprotectors for the prevention and treatment of the effects of radiation poisoning. In these and subsequent documents on similar topics [Annex 1, p.2] States that "existing protectors are far from perfect. A landmark in the search for new chemical remedies is the so-called ideal radioprotector, which must meet the following requirements is to be: 1) high efficiency in the absence of toxicity; 2) the convenience of the dosage form (oral or intramuscular); 3) low cost to manufacture and stability during storage; duration of symptoms of protective action (which must start from the first minutes after administration and last for several hours); 4) the ability to use the drug when exposed to different types of ionizing radiation". When developing methods of monitoring the well-being of the human environment, Federal state scientific institution "Federal medical biophysical Center. A.I. of Burnazyan" [Annex 1, section 3] were formed scientific idea that natural substances can also be seen in the form of natural radioprotectors, because they are activating the protective resources of the body and acting on neurohumoral and immune-hematopoietic (blood-forming) of the regulatory system, improve the General nonspecific resistance of the organism, i.e. stimulate endogenous background of radioresistance (complex endogenous biologically active compounds: amines, thiols, and other antioxidants that suppress the accumulation is detrimental to living cells of excess radiation products of peroxide oxidation)".

As noted by several domestic and foreign researchers [Annex 1, claims 4, 5, 6, 7], for the particular protection of the radiation damage include measures to accelerate the excretion of radionuclides, received it and in the organs and tissues. Accelerated removal (decorporate) of radionuclides from the organism may to a greater or lesser extent, to prevent or interrupt the negative effects of physiological systems mikroorganizmov upon further irradiation, therefore, such events can only conditionally be considered as a preventive. In addition to mechanical methods of removing radionuclides from biological tissues (frequent baths, stimulating sweating, flushing of the stomach and intestines) and apply such funds excretion, as a special diet [Annex 1, item 8] in combination with taking laxatives and diuretics substances; sorbents (and complexing agents), binding radionuclides in patterns, quickly flushed out of the body. Of sorbents are currently considered promising [Annex 1, item 9] ferrocin and polysorin, absorbing, respectively, cesium and strontium, are also used drugs: alginates (containing polysaccharides extracted from algae), high-activity cellulose, preparations of activated carbon, barium sulfate, etc. According to the testimony of representatives of leading Russian medical schools radiologists [Annex 1, paragraph 10] "the most effective medication radioprotectors are representatives of two classes of chemical compounds: mercaptal is ylamino and indolealkylamines. Integral index of the radioprotective efficiency of radioprotectors is the value of a factor reducing the absorbed dose FOOD, or factor changing the dose of feeds that show how many times increases (changes) is equally effective doses when using these pharmaceuticals. As equally effective doses typically compare sub-lethal doses of irradiation (denoted as LD), i.e. the dose causing death in 50% of irradiated animals."

It is known the use of natural substances as natural radioprotectors for the removal of biological tissue of radioactive substances. For example, there is a method of use as a food additive natural zeolite tuff in patent 2063229 [1].

There is also known a technique for accelerating the excretion of radioactive substances, primarily cesium-137 and its analogues from the human body by patent No. 2113228 [2], which consists in receiving the infusion of medicinal herbs that have diuretic, diaphoretic, laxative and digestive action, and potassium herbs in combination with a water-thermal treatment.

The above methods of deducing from biological tissues radioactive substances does not include use for ingestion halogenated natural mineral waters resort With the Chi.

The mechanism of action of halogenated natural mineral waters is based on the ability of monovalent fluorine content in the chemical formula, for example, natural mineral water "lasarevskoye healing" reaches as a specific component of 3.5 mg/l in the total mineralization called water 5,9-6,1 mg/l, more actively than traditional medical schemes to optimize not only the dynamics of the level of lipid peroxidation, but also indicators HCT-test on the Park, which determine the degree of biocenose neutrophilic granulocytes contained in the tested blood volume (1 ml) of individuals exposed to harmful external effects, the cause of which are radionuclides, including products active half-life of salts of heavy metals entering the body of water or food. In this study the immune-hematopoietic (blood-forming) regulatory functions of the above individuals was based on the methods of clarifying the fibrinolytic activity of plasmin, tolerance of blood to the heparin, the identification of such constants of the biochemical status as the activity of glutathione-S-transferase (G-S-T) in saliva, alanine aminotransferase (ALT) and aspartate aminotransferase (ACT). In addition, these properties of natural halogenated mineral water "lasarevskoye Celje is owned confirmed by the study of the dynamics of indicators phagocytic cell protection mikroorganizmov, where played an essential role definition, phagocytic index, i.e. the percentage of actively faguoqitirute cells (phagocytes) and phagocytic index, i.e. the average number of microbes, absorbed one phagocyto individuals exposed to harmful external effects, the cause of which are radionuclides, including products active half-life of salts of heavy metals entering the body of water or food. The dynamics of a subpopulation of T cells bearing surface antigens D3+(Mature T cells), CD4+(the helper), CD8+(suppressors), and the level of performance IgA, IgM, IgG serum was determined by radial immunodiffusion according to G. Mancini using standard antiimmunoglobulin sera.

Based on this mechanism of regulation of parameters of biochemical and immuno-hematopoietic status of named individuals (n=278, p<0,05) was first investigated the influence of physical persons exposed to harmful external effects, the cause of which are radionuclides, including products active half-life of salts of heavy metals entering the body of water or food) drinking balneotherapy using mineralized hydrocarbonate-chloride sodium, alkaline, boric, with a high content of magnesium, iodine and fluorine nature is ne mineral water "lasarevskoye healing" wells No. 84-e Volkonsky field of Sochi (see "Lasarevskoye" according to GOST R 54316-2011. Water natural mineral drinking. General specifications).

Prototype by the present invention no. The analysis of the problem and the data of their own studies allowed the authors to conclude about the feasibility of deducing from biological tissues of radioactive substances by the claimed method of drinking balneotherapy using natural halogenated mineral water "lasarevskoye healing".

The technical result

The technical result achieved by the claimed invention is the improvement of the health status of individuals exposed to harmful external effects, the cause of which are radionuclides, including products active half-life of salts of heavy metals entering the body of water or food, i.e. normalization: 1) indicators of phagocytic cell defenses and a subpopulation of T-cells bearing the surface antigens D3+(Mature T cells), CD4+(the helper), CD8+(suppressors), IgA, IgM, IgG serum and cytokines (IFN-γ, IL-4) blood; 2) levels of products of lipid peroxidation (in heptane and isopropanole phase); 3) basal and stimulated activity of neutrophilic granulocytes (indicators HCT-test Park), kislorodozawisimae biocenose when calculating with the front cytochemical coefficient (test Mrs x Yablokova, 1999) [14]; 4) the fibrinolytic activity of plasmin and tolerance of blood to heparin; 5) level of ALT (alanine aminotransferase) and aspartate aminotransferase (ACT).

Also the technical result is the fact that as a result of use of the claimed copyright of complex drinking balneotherapy 86,3% of the observed individuals (n=240, p<0.05), and subjected to harmful external influences (the cause of which are radionuclides, including products active half-life of salts of heavy metals entering the body of water or food), were classified as "healthy" according to the dynamics of their clinical and functional and laboratory parameters, i.e. macroorganism was not observed the presence of the marker "99mTc - pertechnetate used to determine using gamma cameras company "Toshiba" when identifying the level of accumulation of radioactive substances in biological tissues.

The invention

The technical result is achieved by way of the removal of biological tissue of radioactive substances include the use of halogenated hydro-carbonate-sodium chloride, alkaline, boric, with a high content of magnesium, iodine and fluoride in natural mineral water "lasarevskoye healing" wells No. 84-e Volkonsky field Sochi by the following method: for 30-35 the minutes before meals in small SIPS, six times a day every day for 200-250 ml at t°=(23-24°C), within 45 days, followed by a break for 2-3 days and repeat drinking receiving the same amounts of these natural halogenated mineral water within the next 45 days. The treatment includes a three-year term drinking natural mineral water "lasarevskoye healing", and a specific time daily consumption of this mineral water is determined at 8.00, 10.00, 12.00,14.00, 16.00, 18.00 hours.

Disclosure of inventions

The inventive method includes scientifically based balneotherapy techniques of correction of the consequences of the negative impact of external influences, the cause of which are radionuclides, including products active half-life of salts of heavy metals entering the body of water or food.

The leading of these clinical and laboratory manifestations are: 1) reducing phagocytic cell defenses and destruction of a subpopulation of T cells bearing surface antigens CD3+(Mature T cells), CD4+(the helper), CD8+(suppressors), IgA, IgM, IgG serum and cytokines (IFN-γ, IL-4) blood; 2) levels of products of lipid peroxidation (in heptane and isopropanole phase); 3) basal and stimulated activity of neutrophilic granulocytes (indicators HCT-test Park), their oxygen is independent of biocenose when calculating the average cytochemical coefficient (test Mrs x Yablokova, 1999); 4) reduction in fibrinolytic activity of plasmin and tolerance of blood to heparin; 5) increases in ALT (alanine aminotransferase) and aspartate aminotransferase (ACT).

The inventive method of deducing from biological tissues radioactive substances involves the use of halogenated hydro-carbonate-sodium chloride, alkaline, boric, with a high content of magnesium, iodine and fluoride in natural mineral water "lasarevskoye healing" wells No. 84-e Volkonsky field of Sochi by the following method: for 30-35 minutes before meals in small SIPS, six times per day to 200-250 ml at t°=(23-24°C), within 45 days, followed by a break for 2-3 days and repeat drinking receiving the same amounts of these natural halogenated mineral water for the next 45 days. The treatment includes a three-year term drinking natural mineral water "lasarevskoye healing", and a specific time daily consumption of this mineral water is determined at 8.00, 10.00, 12.00, 14.00, 16.00, 18.00 hours.

Drinking mineral water (certificate of state registration №U from 01.11.2006) with the trade name "lasarevskoye healing" refers to waters with low mineralization Volkonsky or Salenikovich mineral medical-table water is lasarevskoye" and is extracted from the sources:

b) well No. 84-e Volkonsky deposits: mineral water of low salinity, bicarbonate-sodium chloride, alkaline, boric, with a high fluorine content.

The formula of the ionic composition and other characteristics of mineral water "lasarevskoye healing" are shown in table 1.

The content of Halogens (fluorine) in the chemical formula of natural mineral water "lasarevskoye healing" reaches as a specific component of 3.0-3.5 mg/l in the total mineralization called water 5,9-6,1 mg/l

Table 1
No. SLE., fieldName of state registration and trade nameThe formula of the ionic compositionSpecificity, mg/DM3FLOW rate, m3/dUse
No. 84-e Volkovskoe"Lasarevskoye healing"H3BO3274,4 F3,5569,5The filling plants, of the hospital (for General bathing, drinking, and local procedures)

As mentioned above, the mechanism d is istia halogenated natural mineral waters is based on the ability of monovalent fluorine more active than traditional medical schemes to optimize not only the dynamics of the level of lipid peroxidation, but also indicators HCT-test on the Park, which determine the degree of biocenose neutrophilic granulocytes contained in the tested blood volume (1 ml) of individuals exposed to harmful external effects, the cause of which are radionuclides, including products active half-life of salts of heavy metals entering the body of water or food.

The Federal service for supervision of consumer rights protection and human welfare (Rospotrebnadzor), signed by the chief sanitary doctor, Onishchenko issued a Certificate of state registration №U from 01.11.2006 that water mineral dining room "lasarevskoye healing" (THE 9185-002-95093915-06) passed the state registration, registered in the State register and approved for production on the territory of the Russian Federation, import and circulation on the territory of the Russian Federation (Annex 2). This certificate is issued on the basis of balneological conclusions SIC balneology and rehabilitation of the black sea zone control of specialized sanatorium of Ministry from 08.08.06, No. 75, Protocol ATL RDC "Quality" (№ ROSS RU.0001.2117) from 01.08.06, No. 1290. The validity of the certificate of state the civil register is set by the CPS for the entire period of the industrial production of Russian production or supply of imported goods (number of the certificate 0037130).

In addition, the Federal service for supervision of consumer rights protection and human welfare in the water mineral table "lasarevskoye healing" (THE 9185-002-95093915-06) issued by the Sanitary-epidemiological conclusion No. T from 01.11.2006, about the compliance of this mineral table water of the state sanitary-epidemiological rules and norms SanPiN 2.3.2. 1078-01 "Hygienic requirements for safety and nutrition value of food products". This Sanitary-epidemiological conclusion is also signed by the head of Rospotrebnadzor, Onishchenko (Annex 3).

Using the proposed method with the specified modes drinking balneotherapy allowed on a quarterly basis (at the time of observation in the course of 3 years, a statistically significant number of individuals, n=278 at p<0,05) to achieve normalization of the biochemical characteristics of status and immune-hematopoietic (blood-forming) regulatory functions of the above individuals (exposed to harmful external effects, the cause of which are radionuclides, including products active half-life of salts of heavy metals entering the body of water or food), namely: 1) fibrinolytic activity of plasmin, tolerance of blood to the heparin activity put the tion-S-transferase (G-S-T) in saliva, the level of alanine aminotransferase and aspartate aminotransferase (table 2); 2) indicators phagocytic cell protection mikroorganizmov, i.e. the percentage of actively faguoqitirute cells (phagocytes) and phagocytic index and the average number of microbes, absorbed one phagocyto, the dynamics of a subpopulation of T cells bearing surface antigens CD3+(Mature T cells), CD4+(the helper), CD8+(suppressors), and the level of performance IgA, IgM, IgG serum and cytokines (IFN-γ, IL-4) blood (table 3); 3) levels of products of lipid peroxidation (table 4) in heptane and isopropanole phase; 4) basal and stimulated activity (table 5) neutrophilic granulocytes (indicators HCT-test Park), kislorodozawisimae biocenose when calculating the average cytochemical coefficient (test EVGENIY Yablokova, 1999).

Illustration of therapeutic efficacy of the claimed method is the fact that the use proposed by the authors way of drinking balneotherapy on the bases of research: CJSC "Sanatorium "lasarevskoye" (354200, Russia, Krasnodar region, Sochi, Sochi highway 6; the act of implementation No. 40 dated 28.01.2013); CJSC "Sanatorium "starfish" (354200, Russia, Sochi, Lazarevsky district, St. the Victory, 15; the act of implementation No. 100 dated 24.01.2013), 86.3% of the observed individuals (n=240, p<0,05), exposed to harmful external effects is the textbooks (the cause of which are radionuclides, including products active half-life of salts of heavy metals entering the body of water or food), were classified as "healthy" according to the dynamics of their clinical and functional and laboratory parameters, i.e. macroorganism was not observed the presence of the marker "99mTc - pertechnetate used to determine using gamma cameras company "Toshiba GCA-90B" to identify the level of accumulation of radioactive substances in biological tissues. In the control group where patients (n=278, p<0,05) was treated in the same database research (CJSC "Sanatorium "lasarevskoye" (354200, Russia, Krasnodar region, Sochi, Sochi highway 6; the act of implementation No. 40 dated 28.01.2013); CJSC "Sanatorium "starfish" (354200, Russia, Sochi, Lazarevsky district, St. the Victory, 15; the act of implementation No. 100 dated 24.01.2013), standard methods radioprotective therapy (sulfa radioprotectors is a modern derivative of mercaptoethylamine, radioprotective activity which the mechanism of action is associated with the presence of free SH-groups; indoleamine, including serotonin, tryptamine, 5-methoxytryptamine; daily by or serum globulins with normal autoantibodies), therapeutic efficacy was 1.5 times lower (which is presented in table 6).

The same serum globulins (with normal autoantibodies), who introduced intraperitoneally in the experiment in vivarium conditions white mice, turned out to be less effective radioprotectors than natural halogenated mineral water "lasarevskoye healing"used for removing radioactive substances from biological tissues of mice. It should be emphasized that these radioactive substances are introduced in a natural way the mice eating the milk taken by the method of unintentional selection in cows from the zone of radioactive contamination resulting from the Chernobyl accident (3.7 Bq/kg and above, with the aim of determining the Sr90and Cs137). The sample of milk (by weight up to 1.5 kg) was acidified, evaporated on a hotplate and after migration in porcelain cups were applevale to the stage of ashing in a muffle furnace at 400 to 500°C. Then, the filtrate was determined by the content of caesium-137 in the sediment of oxalate isolated from this sample, we determined the levels of strontium-90. In the radiometric measurements revealed the following facts: 1) in the first group of laboratory mice, which were vipavadee for 3 consecutive days the milk taken by the method of unintentional selection in cows from the zone of radioactive contamination resulting from the Chernobyl accident (3.7 Bq/kg and above), there has been an acceleration of excretion of named products half-life of salts of heavy metals, because the mouse in this group is not something which are received in the diet of an unlimited number of halogenated natural mineral water "lasarevskoye healing", but also subjected to forced procedure of dipping in a container with the above-mentioned mineral water 3 times a day, that is 20 minutes or up to 1 hour daily. While the half-life Cs137was in radiation-based measurement in the organism of experimental mice 29 days, a Sr90 -21 days after application of the above techniques use of natural halogenated mineral water "lasarevskoye healing" in the form of a radioprotector. Observations were carried out on a statistically significant level (n=278, p<0,05); 2) in the control group mice, where food animals observed were added sulfur-containing radioprotectors (without the use of natural mineral water "lasarevskoye healing"), the consumption of milk taken by the method of unintentional selection in cows from the zone of radioactive contamination resulting from the Chernobyl accident (3.7 Bq/kg and above, with the aim of determining the Sr90and Cs137), the rate of excretion of the named products half-life of salts of heavy metals was as follows: strontium-90 was available in biological tissues of mice 30-32 days, and cesium-137 was maintained for up to 1.5 months after triple daily drink this milk. The data of this laboratory experiment are also given in table 6.

Heme is poeticeska (hematopoietic) regulatory system is observed individuals (n=240, p<0.05), and subjected to harmful external influences (the cause of which are radionuclides, including products active half-life of salts of heavy metals entering the body of water or food), was evaluated according to the indicators (table 2) fibrinolytic activity of plasmin, tolerance of blood to the heparin activity of glutathione-S-transferase (G-S-T) in the saliva, the level of alanine aminotransferase (ALT) and aspartate aminotransferase (ACT).

Table 2
Differences biochemical statusThe main group (n=278)Control gr. (n=278)
before the treatmentafterbefore the treatmentafter
The activity of glutathione-S-transferase (G-S-T) in saliva, N=127-129 µmol/g proteinEUR 188.4±2,6128,1±1,5190,4±1,6146,9±1,8
ACT (N=25-28 ME)38,9±0,426,7±0,238,6±0,332,4±0,5
The LT (N=28-31 ME) 39,8±0,629,5±0,339,4±0,733,8±0,1
Tolerance of blood to the heparin (N=40-50)73±248±173±158±2
Fibrinolytic activity of plasmin (N=8-15 mm2)6,2±0,49,2±0,16,3±0,27,3±0,1

Commenting on the data in table 2, should indicate that initially deformed figures of hematopoietic (blood-forming) system was regulated by using the inventive method of drinking balneotherapy and had only a tendency to normalize influenced by standard methods radioprotective therapy sulfa radioprotectors is a modern derivative of mercaptoethylamine, radioprotective activity whose mechanism of action is associated with the presence of free SH-groups; indoleamine, including serot NIN, tryptamine, 5-methoxytryptamine; daily by or serum globulins with normal autoantibodies. In addition, the claimed method provides normalization in patients of the main group monitoring indicators alanineaminotransferase is s (from 39.8±0,6 ME to 29.5±0,3 ME when N=28-31 ME) and aspartate aminotransferase (from 38.9±0,4 ME to 26.7±0,2 ME when N=25-28 ME). In the control group indicators ALT ACT after receiving the above-mentioned pharmacological radioprotectors left (respectively) at the level of 33.8±0,1 ME and 32.4±0,5 ME that says on therapeutic efficacy of the claimed method. At the same time, such a significant indicator of the biochemical status of the system the hematopoietic (blood-forming) system, as tolerance of blood to the heparin under the influence of the claimed method, normalized to the level of 48±1 with initially increased to 73±2 when N=40-50 C. with this, the fibrinolytic activity of plasmin (N=8-15 mm2)initially reduced in both groups follow-up values of 6.2-6.3 mm2increased in patients of the main group of observations to 9.2±0.1 mm2remained at the level of 7.3±0.1 mm2patients from the control. The activity of glutathione-S-transferase (G-S-T) in saliva when N=127-129 µmol/g protein amounted to patients of the main group observations (using the claimed method of drinking balneotherapy using natural halogenated mineral water "lasarevskoye healing") 128,1±1.5 µmol/g protein (originally EUR 188.4±2.6 µmol/g protein). The same indicator in patients in the control group remained at the level of 146,9±1.8 µmol/g protein, which was higher by almost 14% from the norm.

Dynamics of phagocytic cell defenses and other character who sticks immune status are presented in table 3.

Commenting on the data of table 3, should indicate that initially the percentage of normal values immune characteristics in the study group observations were made of the total number of observed patients: a) phagocytic index 58%; b) on the maturation of CD4+lymphocytes to 19.3%; b) on the maturation of CD8+lymphocytes to 18.3%; d) activation of B-lymphocytes to 21.1%; d) in terms of normal sitestatistics effect of 22.2%. After implementation of the claimed method the percentage of normal values immune characteristics ranged from the total number of observed patients: a) phagocytic index 93%; b) on the maturation of CD4+lymphocytes 75,6%; b) on the maturation of CD8+lymphocytes from 71.3%; d) activation of b-lymphocytes 73,1%; d) in terms of normal sitestatistics effect to 72.4%. In the control group similar figures were 1.3-1.5 times lower. Similar dynamics were observed in the main and control groups observed patients (before and after administration of pharmacological or natural radioprotectors in the form of mineral water "lasarevskoye healing"), when initially reduced to ensure the level of immunoglobulin IgM (1,41±0.04 with N=to 1.59-1.63 g/l) were normalized in patients of the main group, not reaching threshold standards of patients from the control group observations, and initially elevated in the study group monitoring of IgG and IgA, respectively, fell the of n to values 11,70±0.04 g/l 1.48±0.03 g/l (and not coming to normal in patients receiving only medical radioprotectors). The latter was significantly (p<0,05) correlated with decreased initially violated characteristics of CD 11 b+CD 20+CD 25+CD 95+and HLA-DR+that was achieved, including through scientific inventive method drinking balneotherapy using halogenated natural mineral water "lasarevskoye healing".

Dynamics of the level of lipid peroxidation (comparing the effectiveness of drug and natural radioprotectors) are presented in table 4.

Table 4
Products FLOOR in the relative. units extinctionThe main group (n=278)Control gr. (n=278)
before the treatmentafterbefore the treatmentafter
Heptane phase:
E232/220-diene conjugates (N=0,542-0,544)0,734±0,0120,543±0,001advanced 0.729±0,0170,583±0,010
E278/220-conjugate ketotriose (N=0,382-0,385)0,449±0,0140,384±0,0010,446±0,0120,397±0,001
E400/220-chiffony reasons (N=0,012-0,014)0,028±0,0030,013±0,0010,029±0,0020,019±0,001
Isopropanolate phase:
E232/220-diene conjugates (N=0,445-0,448)determined as 0.720±0,0220,446±0,0010,721±0,0170,498±0,003
E278/220-conjugate ketotriose (N=0,275-0,277)0,410±0,0240,276±0,0010,409±0,0250,283±0,001
E400/220-chiffony reasons (N=0,047-0,049)0,098±0,0050,048±0,0010,099±0,0030,064±0,002

Commenting on the data of table 4, it should be emphasized that the claimed method of drinking balneotherapy is more effective than standard methods radioprotective therapy, i.e. modern derivative m is repeatedley, 5-methoxytryptamine or serum globulins with normal autoantibodies had an impact on the normalization E/220-diene conjugates (N=0,542-0,544) in heptane phase with the initial level 0,734±0,012 to 0,543±0.001 relative. units extinction. At the same time diene conjugates in isopropanole phase (N=0,445-0,448) is normalized in the main group of observations with the initial level determined as 0.720±0,022 to 0,446±0,001 remained at the level 0,498±0,003 a relative. units extinction upon completion of the course medical radioprotectors. A similar trend has been for other products of lipid peroxidation, including paired ketotriose and chiffony Foundation. The latter was in direct correlation with the characteristics of basal and stimulated activity of neutrophilic granulocytes, which are presented in table 5.

Table 5
Biocenose neutrophilic granulocytesThe main group (n=278)Control gr. (n=278)
before the treatmentafterbefore the treatmentafter
1. The results of HCT-test Park:
- basal activity of neutrophilic granulocytes (N=10%)8,1%9,9%8,2%9,3%
- stimulated activity of neutrophilic granulocytes (N=40-60%)29,8%54,4%29,9%39,2%
2. The assessment of the content of lysosomal cationic proteins (test EVGENIY Yablokova, 1999) when calculating the average cytochemical coefficient (CCS) kislorodozawisimae biocenose neutrophilic granulocytes
(N=1.5-1.7 services. unit)
1,07±0,04 srvc. units1,62±0,03 services. units1,09±0.05 srvc. unitsof 1.26±0.02 srvc. units

Commenting on the data of table 5, it should be emphasized that the claimed method was possible to normalize the indicator kislorodozawisimae biocenose neutrophilic granulocytes (N=1.5-1.7 services. units), which initially reduced to 1.07±0.04 srvc. units) after administration of the claimed method of use of natural radioprotector in the form of mineral water "lasarevskoye healing" rose to the level of 1.2±0.03 services. units in patients of the main group observations. Simultaneously, the main group observations basal activity of neutrophilic granulocytes increased to 9.9% (originally by 8.1% when N=10%), remained in the control group observations at the level of 9.3%. Stimulated activity of neutrophilic granulocytes (N=40-60%) in the study group was (after the implementation of the claimed method) to 54.4%, remained in the control group at the level of 39.2%.

The final therapeutic efficacy of the claimed method (when implementing the experimental part of the research justification) are presented in table 6.

Table 6
Experimental indicatorsThe main group (n=278)Control gr. (n=278)
before the treatmentafterbefore the treatmentafter
1. The level of decorporation (excretion) from the body of the observed patients radionuclides, natural penetrated by water or foodhealthy 0%turn the key to healthy 86,3% healthy 0%healthy 55,4%
products:(100 days)(100 days)
Cs13745 days70 days
Sr9040 days61 days
2. The level of decorporation (excretion) of biological tissues of mice radionuclides penetrated in a natural way with milk taken by the method of unintentional selection in cows from the zone of radioactive contamination resulting from the Chernobyl accident (3.7 Bq/kg and above):100 days100 days
Cs13729 days 44 days
Sr9021 days32 days

Commenting on the data of table 6, it should be noted that in the first group of laboratory mice, which were vipavadee for 3 consecutive days the milk taken by the method of unintentional selection in cows from the zone of radioactive contamination resulting from the Chernobyl accident (3.7 Bq/kg and above), were detected after application of the inventive method the acceleration of excretion of named products half-life of salts of heavy metals. While the half-life Cs137was in radiation-based measurement in the organism of experimental mice 29 days, and Sr90- 21 days. In the control group, similar rates were 1.5 times higher and were respectively 44 and 32 days. At the same time, the level of decorporation (excretion) from the body of the observed patients radionuclides, natural penetrated by water or food, under the influence of the claimed method was higher than 1.5 times than the standard methods radioprotective therapy sulfa radioprotectors or indoleamine, including serotonin, tryptamine, 5-methoxytryptamine. This took into account the camping, what the national Standard GOST R 54316-2011(natural mineral Water drinking natural mineral halogenated water "lasarevskoye healing" with General mineralization of 5.0-6.0 g/DM3does not imply limitations in daily and course doses consumption, and in the composition of its biologically active components present in industrial concentrations ions of boron, magnesium and fluorine, contributing to the normalization of clinical, physiological, immunological and biochemical constants of individuals exposed to harmful external effects, the cause of which are radionuclides, including products active half-life of salts of heavy metals entering the body of water or food.

Examples of the method

Example 1. The patient Himself s, 36 years old, and a/b No. 798/12 passed course drinking balneotherapy claimed process at CJSC "Sanatorium "lasarevskoye" (354200, Russia, Krasnodar region, Sochi, Sochi highway 6) 04.12.2012 on 18.01.2013 (45 days, the 1st course drinking balneotherapy using natural halogenated mineral water "lasarevskoye healing") and 23.01.2013 on 11.03.2013 (45 days 2nd course drinking balneotherapy using natural halogenated mineral water "lasarevskoye healing"). Diagnosis on arrival at the sanatorium map: adverse impact is authorized radiation (Z 57.1 ICD-X). From the anamnesis: the patient within 10 years working as postanalytical equipment in nuclear power plants. Complaint for permanent weakness (malaise), loss of physical capacity, drowsiness, increased bleeding from the tissues when small (domestic or industrial) lesions of the skin, headache, especially in the evening, after exercise, irritability and conflicts for minor reasons, the relative reduction in sexual potency. Is in the dispensary in the departmental health care institution at the place of production activities in the last 3 years about syndromal together the above clinical and functional manifestations caused by the production of risk factors and classified according to International statistical classification of diseases in the Class XXI Factors influencing health status and contact with health institutions"that are officially classified in category Z 57.1 ICD-X with the phrase "Adverse effects of the production of radiation." The treatment was carried out in the last 3 years at the place of deployment of departmental health care facilities (using standard methods radioprotective therapy, including sulfur-containing radioprotectors with the belt derivative mercaptoethylamine, radioprotective activity whose mechanism of action is associated with the presence of free SH-groups, as well as indolylmaleimide, including serotonin, tryptamine, 5-methoxytryptamine). In the absence of planned therapeutic effect was sent to the departmental health care institution in the course of drinking balneotherapy in CJSC "Sanatorium "lasarevskoye" (Sochi). Complaints at admission: permanent weakness (malaise), loss of physical capacity, drowsiness, increased bleeding from the tissues when small (domestic or industrial) lesions of the skin, headache, especially in the evening, after exercise, irritability and conflicts for minor reasons, the relative reduction in sexual potency. Objectively: the patient is a proper physique, normal power (when the height is 172 cm and has a weight of 75.8 kg). The vesicular breathing, wheezing no. Heart sounds rhythmic, somewhat muted. Percutere: the borders of relative heart dullness within normal limits, tongue moist, coated small whitish bloom. The abdomen is soft, painless. Percutere border of the liver is on the edge of the costal arch. Chair - irregular (the tendency to constipation). Urination free, painless, Newcastle. Symptom of Pasternack negative on both side is N. Urine color is straw-yellow.

Laboratory tests: complete blood count - hemoglobin 134 g/l, CVP 0.9, platelets 210·109leukocyte 10,3·109, EOS. 6, PAL. 3, segm. 73, limp. 25, mon. 10, the sedimentation rate of 18 mm/h; obshch. an. urine - tank weight 1012, transp. full. reacts. sour, no protein, no sugar, an epithelium flat, small Qty, leukocytes 2-4 p/TREN., no mucus.

Clinical and laboratory characteristics: activity of glutathione-S-transferase (G-S-T) in saliva, N=127-129 µmol/g protein EUR 188.4±2.6 µmol/g protein; ACT (N=25-28 ME) 38,9±0,4 ME; ALT (N=28-31 ME) 39,8±0,6 ME; tolerance blood to heparin (N=40-50) 73±2; fibrinolytic activity of plasmin (N=8-15 mm2) of 6.2±0.4 mm2; The FLOOR in the relative. units extinction: 1) heptane phase: E232/220-diene, conju-Gata (N=0,542-0,544) 0,734±0,012; E278/220-conjugate ketotriose (N=0,382-0,385) 0,449±0,014; E400/220-chiffony reasons (N=0,012-0,014) 0,028±0,003 a relative. units extinction; 2) isopropanolate phase: E/220-diene conjugates (N=0,445-0,448) determined as 0.720±0,022; E/220-conjugate ketotriose (N=0,275-0,277) 0,410±0,024; E400/220-chiffony reasons (N=0,047-0,049) 0,098±0,005 a relative. units extinction. The percentage of normal faguoqitirute of cells, the phagocytic index (N=92%), laboratory reduced to 58%, and the phagocytic index, i.e. the average number of microbes, absorbed one phagocyto (N=8-10), reduced to 5. Cytokines blood IFN-γ, PG/ml (N=25-28) 34,26±0,28; IL-4, PG/ml (N=19-20) 36,10±0,15; Th1/Th2 dysbalance (N=1.4 To 1.5) 1,65±0,02; IgM/ g/l (N=1,59-1,63) 1,41±0,04; IgG, g/l (N=11,2-11,9) 16,98 the 0,21; IgA, g/l (N=1.5) To 2.18±0.02 And Other indicators of immune status at admission: CD4/CD8 (N=1,98-1,99) 1,92±0,02; CD16+, % (N=11,1-11,4) 19, 22 the±0,11; CD25+, % (N=6,17-to 6.19) to 4.98±0,26; HLA-DR+, % (N=12,4-12,6) 9,59±0,41; CD95+, % (N=24,1-24,3) 19,28±0,16. Biocenose neutrophilic granulocytes, including the results of HCT-test Park: basal activity of neutrophilic granulocytes (N=10%) 8,1%; stimulated the activity of neutrophilic granulocytes (N=40-60%) 29.8 per cent. Laboratory evaluation of the content of lysosomal cationic proteins (test EVGENIY Yablokova, 1999) when calculating the average cytochemical coefficient (CCS) kislorodozawisimae biocenose neutrophilic granulocytes (N=1.5 to 1.7 usled) 1,07±0,04 used

According to history, clinical, laboratory, instrumental and functional studies for admission to the sanatorium diagnosed Adverse effects of industrial radiation (Z 57.1 ICD-X), contributing to the clinical and functional deformity (deterioration) indicators of biocenose neutrophilic granulocytes, characteristics, GENDER, rheological properties of blood, decreased activity of glutathione-S-transferase (G-S-T), phagocytic index and phagocytic index and maturation of CD4+-lymphocytes, CD8+-lymphocytes, activated b-lymphocytes.

Treatment: designated copyright scheme derive from biological tissues radioactive substances, on which the includes the use of halogenated hydro-carbonate-sodium chloride, alkaline, boric, with a high content of magnesium, iodine and fluoride in natural mineral water "lasarevskoye healing" wells No. 11-M Salenikovich field of Sochi by the following procedure: 30 minutes before meals in small SIPS, six times a day every day of 200 ml at t°=23°C, for 45 days. The daily consumption of mineral water at 8.00, 10.00, 12.00, 14.00, 16.00, 18.00 hours. Followed by a break of 2 days and repeat drinking receiving the same amounts of these natural halogenated mineral water within the next 45 days.

As a result of the treatment: indicates a return to feeling normal health, the disappearance of increased bleeding when microtraumas, the normalization of the parameters of sexual life, reducing irritability and conflict for minor reasons, the restoration of regular (normal consistency) of the chair.

Laboratory tests: complete blood count - hemoglobin 124 g/l, Cup 1,0, platelets 209·109leukocyte 6,1·109, EOS. 2, PAL. 1, segm. 61, limp. 15, mon. 5, the sedimentation rate of 12 mm/h; obshch. an. urine - tank weight 1012, transp. full. reacts. sour, no protein, no sugar, an epithelium flat, small Qty, leukocytes 2-4 p/TREN., no mucus.

Clinical and laboratory characteristics: activity of glutathione-S-transferase (G-S-T) in saliva, N=127-129 µmol/g b is the left main coronary artery 128/1±1.5 µmol/g protein; ACT (N=25-28 ME) TO 26.7±0,2 ME; ALT (N=28-31 ME) TO 29.5±0,3 ME; tolerance blood to heparin (N=40-50) 48±1; fibrinolytic activity of plasmin (N=8-15 mm2) 9,2±0.1 mm2; The FLOOR in the relative. units extinction: 1) heptane phase: E/220-diene conjugates (N=0,542-0,544) 0,543±0,01; E278/220-conjugate ketotriose (N=0,382-0,385) 0,384±0,01; E400/220-chiffony reasons (N=0,012-0,014) 0,013±0.01 relative. units extinction; 2) isopropanolate phase: E/220-diene conjugates (N=0,445-0,448) 0,446±0,01; E278/220-conjugate ketotriose (N=0,275-0,277) 0,276±0,01; E400/220-chiffony reasons (N=0,047-0,049) 0,048±0.01 relative. units extinction. The percentage of normal faguoqitirute of cells, the phagocytic index (N=92%), laboratory increased to 93%, and the phagocytic index, i.e. the average number of microbes, absorbed one phagocyto (N=8-10), increased to 9. Cytokines blood IFN-γ, PG/ml (N=25-28) 27,07±0,02; IL-4, PG/ml (N=19-20) 19,67±0,03; Thl/Th2 (N=1.4 to 1.5) 1/47±0,01; IgM, g/l (N=1,59-1,63) Of 1.62±0,01; IgG, g/l (N=11,2-11,9) 11,70±0,04; IgA, g/l (N=1.5) to 1.48±0.03 in. Other indicators of immune status at admission: CD4/CD8 (N=1,98-1,99) 1,99±0,01; CD16+, % (N=11,1-11,4) of 11.2±0,09; CD25+, % (N=6,17-to 6.19) 6,18±0/01; HLA-DR+, % (N=12,4-12,6) 12,47±0,02; CD95+, % (N=24,1-24,3) 24,12±0,02. Biocenose neutrophilic granulocytes, including the results of HCT-test Park: basal activity of neutrophilic granulocytes (N=10%) 9,9%; stimulated the activity of neutrophilic granulocytes (N=40-60%) to 54.4%. Laboratory evaluation of the content of lysosomal cationic proteins (test Mrs x, I have lakova, 1999) when calculating the average cytochemical coefficient (CCS) kislorodozawisimae biocenose neutrophilic granulocytes (N=1.5-1.7 services. units) of 1.62±0.03 services. units

Thus, according to current criteria patient Himself s, 36 years old, and a/b No. 798/12 held course drinking balneotherapy claimed process at CJSC "Sanatorium "lasarevskoye" (354200, Russia, Krasnodar region, Sochi, Sochi highway 6) 04.12.2012 on 18.01.2013 (45 days, the 1st course drinking balneotherapy using natural halogenated mineral water "lasarevskoye healing") and 23.01.2013 on 11.03.2013 (45 days 2nd course drinking balneotherapy using natural halogenated mineral water "lasarevskoye healing"), recognized as healthy. Recommendation - binding repeat treatment on a quarterly basis over a three-year term drinking natural mineral water "lasarevskoye healing", and a specific time daily consumption of this mineral water is determined at 8.00, 10.00, 12.00,14.00, 16.00, 18.00 hours.

Example 2. Patient Paradise Islands, 34, and/b No. 801/12 passed course drinking balneotherapy claimed process at CJSC "Sanatorium "lasarevskoye" (354200, Russia, Krasnodar region, Sochi, Sochi highway 6) 05.12.2012 on 19.01.2013 (45 days, the 1st course drinking balneotherapy using natural halogenated mineral water "Lazarevska the healing") and 24.01.2013 on 12.03.2013 (45 days, 2nd course drinking balneotherapy using natural halogenated mineral water "lasarevskoye healing"). Diagnosis on arrival at the sanatorium map: adverse effects of industrial radiation (Z 57.1 ICD-X). From the anamnesis: the patient within 8 years of experience operator technical control equipment at nuclear power plants. Complaint for permanent weakness (malaise), loss of physical capacity, drowsiness, increased bleeding from the tissues when small (domestic or industrial) lesions of the skin, headache, especially in the evening, after exercise, irritability and conflicts for minor reasons, algodonera and irregular (delay of up to 5-8 days from the planned offensive) monthly. Is in the dispensary in the departmental health care institution at the place of production activities in the last 4 years about syndromal together the above clinical and functional manifestations caused by the production of risk factors and classified according to International statistical classification of diseases in the Class XXI Factors influencing health status and contact with health institutions"that are officially classified in the ubrique Z 57.1 ICD-X with the phrase "Adverse effects of the production of radiation." The treatment was carried out in the last 4 years at the place of deployment of departmental health care facilities (using standard methods radioprotective therapy, including sulfur-containing radioprotectors is a modern derivative mercaptoethylamine, radioprotective activity whose mechanism of action is associated with the presence of free SH-groups, as well as indolylmaleimide, including serotonin, tryptamine, 5-methoxytryptamine). In the absence of planned therapeutic effect was directed by the departmental health care institution in the course of drinking balneotherapy in CJSC "Sanatorium "lasarevskoye" (Sochi). Complaints at admission: permanent weakness (malaise), loss of physical capacity, drowsiness, increased bleeding from the tissues when small (domestic or industrial) lesions of the skin, headache, especially in the evening, after exercise, irritability and conflicts for minor reasons, algodonera and irregular (delay of up to 5-8 days from the planned offensive) monthly. Objectively: the patient the right physique, several low power (when the height is 158 cm has a weight of 54.1 kg). The vesicular breathing, wheezing Nittany heart rhythmic, somewhat muted. Percutere: border relative activities is Noah cardiac dullness within normal limits, tongue moist, coated small whitish bloom. The abdomen is soft, painless. Percutere border of the liver is on the edge of the costal arch. Chair - irregular (the tendency to constipation). Urination free, painless, Newcastle. Symptom of Pasternack negative on both sides. Urine color is straw-yellow.

Laboratory tests: complete blood count - hemoglobin 129 g/l, CVP 0.9, platelets 212·109leukocyte 12,4·109, EOS. 5, PAL. 5, segm. 72, limp. 26, mon. 11, the sedimentation rate of 20 mm/h; obshch. an. urine - tank weight 1010, transp. full. reacts. sour, no protein, no sugar, an epithelium flat, small Qty, leukocytes 2-3 n/SREN., no mucus.

Clinical and laboratory characteristics; the activity of glutathione-S-transferase (G-S-T) in saliva, N=127-129 µmol/g protein 186,2±1.5 µmol/g protein; ACT (N=25-28 ME) 38,5±0,2 ME; ALT (N=28-31 ME) AND 39.7±0,3 ME; tolerance blood to heparin (N=40-50) 71±3; fibrinolytic activity of plasmin (N=8-15 mm2) of 6.1±0.3 mm2; The FLOOR in the relative. units extinction: 1) heptane phase: E/220-diene conjugates (N=0,542-0,544) 0,732±0,009; E278/220-conjugate ketotriose (N=0,382-0,385) 0,448±0,011; E400/220-chiffony reasons (N=0,012-0,014) 0,029±0,004 a relative. units extinction; 2) isopropanolate phase: E232/220-diene conjugates (N=0,445-0,448) 0,721±0,023; E278/220-conjugate ketotriose (N=0,275-0,277) 0,409±0,025; E400/220-chiffony reasons (N=0,047-0,049) 0,097±0.002 relative. units extinction. The percentage of normal fagalicious the cells, i.e. phagocytic index (N=92%), laboratory reduced to 59%, and the phagocytic index, i.e. the average number of microbes, absorbed one phagocyto (N=8-10), reduced to 4. Cytokines blood IFN-γ, PG/ml (N=25-28) 34,22±0,17; IL-4, PG/ml (N=19-20) 36,08±0,04; Th1/Th2 (N=1.4 To 1.5) 1,64±0,01; IgM, g/l (N=1,59-1,63) 1,42±0,02; IgG, g/l (N=11,2-11,9) 16,85±0,12; IgA, g/l (N=1.5) of 2.16±0.03 in. Other indicators of immune status at admission: CD4/CD8 (N=1,98-1,99) 1,91±0,01; CD16+, % (N=11,1-11,4) 19,19±0,05; CD25+, % (N=6,17-to 6.19) 4,96±0/13; HLA-DR+, % (N=12,4-12,6) being 9.61±0,32; CD95+, % (N=24,1-24,3) 19,24±0/05. Biocenose neutrophilic granulocytes, including the results of HCT-test Park: basal activity of neutrophilic granulocytes (N=10%) 8,2%; stimulated the activity of neutrophilic granulocytes (N=40-60%) to 30.1%. Laboratory evaluation of the content of lysosomal cationic proteins (test EVGENIY Yablokova, 1999) when calculating the average cytochemical coefficient (CCS) kislorodozawisimae biocenose neutrophilic granulocytes (N=1.5-1.7 services. units) of 1.06±0.06 srvc. units

According to history, clinical, laboratory, instrumental and functional studies for admission to the sanatorium diagnosed Adverse effects of industrial radiation (Z 57.1 ICD-X), contributing to the clinical and functional deformity (deterioration) indicators of biocenose neutrophilic granulocytes, characteristics, GENDER, rheological properties of blood, decrease of activity of glutation-S-transferase (G-S-T), phagocytic index and phagocytic index and maturation of CD4+-lymphocytes, CD8+-lymphocytes, activated b-lymphocytes.

Treatment: designated copyright scheme derive from biological tissues radioactive substances, which includes the use of halogenated hydro-carbonate-sodium chloride, alkaline, boric, with a high content of magnesium, iodine and fluoride in natural mineral water "lasarevskoye healing" wells No. 84-e Volkonsky field of Sochi, according to the following procedure: for 35 minutes before meals in small SIPS, six times a day, 250 ml at t°=24°C for 45 days. The daily consumption of mineral water at 8.00, 10.00, 12.00, 14.00, 16.00, 18.00 hours. Followed by a break for 3 days and repeat drinking receiving the same amounts of these natural halogenated mineral water within the next 45 days.

As a result of the treatment: indicates a return to feeling normal health, the disappearance of increased bleeding when microtraumas, normalization of the regular onset of menstruation, reducing irritability and conflict for minor reasons, the restoration of regular (normal consistency) of the chair.

Laboratory tests: complete blood count - hemoglobin 123 g/l, Cup 1,0, thrombosis is the ITA 208·10 9leukocyte 6,2·109, EOS. 1, PAL. 2, segm. 56, limp. 8, mon. 3, the sedimentation rate of 14 mm/h; Gen. an. urine - tank weight 1012, transp. full. reacts. sour, no protein, no sugar, an epithelium flat, small Qty, leukocytes 2-3 n/SREN., no mucus.

Clinical and laboratory characteristics: activity of glutathione-S-transferase (G-S-T) in saliva, N=127-129 µmol/g protein of 128.6±0.2 µmol/g protein; ACT (N=25-28 ME) TO 26.6±0,3 ME; ALT (N=28-31 ME) 29,2±0,4 ME; tolerance blood to heparin (N=40-50) 47±2; fibrinolytic activity of plasmin (N=8-15 mm2) of 9.6±0.2 mm2; The FLOOR in the relative. units extinction: 1) heptane phase: E/220-diene, conju-Gata (N=0,542-0,544) 0,544±0,01; E/220-conjugate ketotriose (N=0,382-0,385) 0,383±0,01; E400/220-chiffony reasons (N=0,012-0,014) of 0.014±0.01 relative. units extinction; 2) isopropanolate phase: E/220-diene conjugates (N=0,445-0,448) 0,447±0,01; E/220-conjugate ketotriose (N=0,275-0,277) 0,277±0,01; E400/220-chiffony reasons (N=0,047-0,049) 0,049±0.01 relative. units extinction. The percentage of normal faguoqitirute of cells, the phagocytic index (N=92%), laboratory increased to 91%, and the phagocytic index, i.e. the average number of microbes, absorbed one phagocyto (N=8-10), increased to 8. Cytokines blood IFN-γ, PG/ml (N=25-28) 27,35±0,04; IL-4, PG/ml (N=19-20) 19,42±0,02; Thl/Th2 (N=1.4 To 1.5) 1,45±0,01; IgM, g/l (N=1,59-1,63) 1,61±0,02; IgG, g/l (N=11,2-11,9) 11,44±0,03; IgA, g/l (N=1.5) 1,49±0,01. Other indicators of immune status at admission: CD4/CD8 (N=1,98-1,99) 1,98±0,02; CD16+, % (N=11/1-11,4) 11,3±0,03; CD25+/sup> , % (N=6,17-to 6.19) to 6.19±0,01; HLA-DR+, % (N=12,4-12,6) 12,45±0,01; CD95+, % (N=24,1-24,3) 24,18±0,03. Biocenose neutrophilic granulocytes, including the results of HCT-test Park: basal activity of neutrophilic granulocytes (N=10%) 9,8%; stimulated the activity of neutrophilic granulocytes (N=40-60%) of 51.6%. Laboratory evaluation of the content of lysosomal cationic proteins (test EVGENIY Yablokova, 1999) when calculating the average cytochemical coefficient (CCS) kislorodozawisimae biocenose neutrophilic granulocytes (N=1.5-1.7 services. units) of 1.61±0.04 srvc. units

Thus, according to current criteria patient Paradise Islands, 34, and/b No. 801/12 held course drinking balneotherapy claimed process at CJSC "Sanatorium "lasarevskoye" (354200, Russia, Krasnodar region, Sochi, Sochi highway 6) 05.12.2012 on 19.01.2013 (45 days, the 1st course drinking balneotherapy using natural halogenated mineral water "lasarevskoye healing") and 24.01.2013 on 12.03.2013 (45 days 2nd course drinking balneotherapy using natural halogenated mineral water "lasarevskoye healing"), recognized as healthy. Recommendation - binding repeat treatment on a quarterly basis over a three-year term drinking natural mineral water "lasarevskoye healing", and a specific time daily consumption of this mineral water is determined at 8.00,10.00, 12.00, 14.00, 16.00, 18.00 hours.

Example 3. In the experiment, the radioactive substance was administered in a natural way white laboratory mice (ntotal=556) by eating the milk taken by the method of unintentional selection in cows from the zone of radioactive contamination resulting from the Chernobyl accident (3.7 Bq/kg and above, with the aim of determining the Sr90and Cs137). The sample of milk (by weight up to 1.5 kg) was acidified, evaporated on a hotplate and after migration in porcelain cups were applevale to the stage of ashing in a muffle furnace at 400 to 500°C. Then, the filtrate was determined by the content of caesium-137 in the sediment - oxalate isolated from this sample, we determined the levels of strontium-90. In the radiometric measurements revealed the following facts: 1) in the first group of mice (n=278, p<0,05), which was vipavadee for 3 consecutive days the milk taken by the method of unintentional selection in cows from the zone of radioactive contamination resulting from the Chernobyl accident (3.7 Bq/kg and above), there has been an acceleration of excretion of named products half-life of salts of heavy metals, because the mouse in this group not only received dietary unlimited number of halogenated natural mineral water "lasarevskoye healing"but is subjected to forced procedure of dipping in a container with the above-mentioned mineral water 3 times a day, i.e. for 20 minutes or up to 1 hour daily. While the half-life Cs137was in radiation-based measurement in the organism of experimental mice 29 days, a Sr90- 21 days from the time of application of the above techniques use of natural halogenated mineral water "lasarevskoye healing" as radioprotector; 2) in the control group (n=278, p<0,05) mice, where food animals observed were added sulfur-containing radioprotectors (without the use of natural mineral water "lasarevskoye healing") against human consumption of the milk taken by the method of unintentional selection in cows from the zone of radioactive contamination resulting from the Chernobyl accident (3.7 Bq/kg and above, with the aim of determining the Sr90and Cs137), the rate of excretion of the named products half-life of salts of heavy metals was as follows: strontium-90 was available in biological tissues of mice 30-32 days, and cesium-137 was maintained for up to 1.5 months after triple daily drink this milk.

These data allow us to conclude about the efficiency of the proposed method of removal of biological tissue of radioactive substances with the use of drinking mineral water with the trade name "lasarevskoye healing". D. the I individuals, subjected to the adverse effects of radiation, the preferred method can be used at the stage of outpatient treatment in outpatient and in health facilities.

SOURCES of INFORMATION

1. RF patent №2063229. Tool for removing deposited in the body of radionuclides (published: 10.07.1996).

2. RF patent №113228. Way to accelerate the excretion of radioactive substances, primarily cesium-137 and its analogues from the human body (published: 20.06.1998).

Appendix # 1

References

1. Cesium-137. Determination in foods. Methodical instructions MZ the Russian Federation No. 5779-91. - M.: Medicine, 1991. - 142 S.

2. Basic sanitary rules for radiation safety (OSPORB-99)SP 2.6.1. 799-99. - M.: RIO MOH, 2000. - 148 C.

3. Cesium-137. Control methods. Physical factors. Determination of specific activity in food products. HOWTO (MUK 4.3.2504-09).- Federal medical biophysical Center. A.I. of Burnazyan, 2009. - 79 S.

4. Vodnikova L.V., Koryagin A.S., A.A. Eliseev Influence of EHF-radiation on the blood system and lipid peroxidation in experimental radiation sickness // Vestnik of Novgorod state University. N. I. Lobachevsky. No. 2. - 2001.- Pp.31-36.

5. Lumps M., Lebedev V.N. A practical guide for radiation protection in uskoritel the x charged particles. ISD-E. - M.: Izd-vo "Energoizdat", 2001. - 294 S.

6. Kozlov, V.F. Reference radiation safety. Ed. 6-E. - M.: Izd-vo "Energoatomizdat", 2002. - 318 S.

7. Mashkovich, VP, Kudryavtseva F. W. Protection against ionizing radiation. The Handbook. Ed. 5-E. - M.: Izd-vo "Energoatomizdat", 2000. - 182 C.

8. Tutelian V.A. et al. Methodology liberalized diet for persons exposed to harmful external effects of radiation // Modern diet therapy: proceedings of the IV all-Russian. Conf.- Nizhny Novgorod, 2002. - P.4-8.

9. HOWTO "Determination of individual effective and equivalent doses and organization of control of occupational exposure under controlled conditions of handling of radiation sources. General requirements" MU 2.6.1.016-2000. - M.: RIO Corporation, 2000. - 226 C.

10. Ilyin L.A., Kirillov V.F., Korenkov I.P. Radiation safety and protection. M.: Medicine, 1996. - 296 S.

11. Seas A.N., Zykova A.S. Methodical recommendations on sanitary control over the content of radioactive substances in the external environment. - M.: Atomizdat, 1980. - 336 S.

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1. The method of deducing from biological tissues radioactive substances involves the use of halogenated hydro-chlor is ne sodium, alkaline, boric, with a high content of magnesium, iodine and fluoride in natural mineral water "lasarevskoye healing" wells No. 84-e Volkonsky field of Sochi by the following method: for 30-35 minutes before meals in small SIPS, six times per day to 200-250 ml at t°=(23-24°C), within 45 days, followed by a break for 2-3 days and repeat drinking receiving the same amounts of these natural halogenated mineral water within the next 45 days, and the treatment includes a three-year term drinking natural mineral water "Lazarevskoye healing".

2. The method according to claim 1, including daily consumption of mineral water at 8.00, 10.00, 12.00, 14.00, 16.00, 18.00 hours.



 

Same patents:

FIELD: medicine.

SUBSTANCE: food ration is added with multi-component natural concentrated food products (NCFP) with high concentrations of biologically active substances (BAS) of herbal (HNCFP) and (or) protein-herbal (PHNCFP) raw material, for the purpose of nutritional support of sportsmen doing various sports, their individual physiological requirements; that results in recovering a set of characteristics of physiological functions and qualities determining a degree of activity of morphofunctional body systems, activities of daily living and professional performance, with providing preventing donozological and pathological conditions, achieving high sport scores. The above food products can be presented by NCFP Antitox and NCFP SportAtiv-2.

EFFECT: invention provides easier exercise tolerance and recovery thereafter, improving health in sportsmen.

5 cl

FIELD: medicine.

SUBSTANCE: method involves preliminary intraperitoneal single administration of 5% aqueous alloxan in a dose of 15 mg/kg of body weight into a rat's body on an empty stomach. That is followed by administering afobazol under conditions of oxidative stress after observing the rat's blood glucose gain at least twice. Afobazol is administered subcutaneously in a dose of 10 mg/kg of body weight once a day for 30 days with underlying administration of L-arginine in a dose of 10 mg/kg of body weight or with underlying NG-nitroarginine methyl ester (L-NAME)-inhibitor of NOS-3 enzyme in a dose of 25 mg/kg of animal's weight.

EFFECT: method enables correcting the oxidative stress and NO-producing endothelial dysfunction accompanying vascular complications of diabetes mellitus.

1 dwg, 6 tbl, 1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to rehabilitation medicine and concerns prevention of meteopathic reactions. That is ensured by administering an adaptogene agent presented by a phytococktail containing mixed 70% tinctures of eleuterococcus, common licorice and rhodiola rosea in the ratio of 2:1:1. The cocktail is introduced in a dose of 10-15 drops for two weeks once a day, taking into account an individual's chronotype. That is followed by a magnetic-infrared-laser exposure covering the acupuncture points Tr(X)5 - Wai Guan, E(III)36 - Zuo San Li, Tr(X)15 - Tian Liao and MC(IX)5 - Jian Shi through an applicator wetted in the phytococktail containing 70% alcoholates of rhodiola rosea, common licorice, yellow starwort and spiny eleuterococcus in the ratio of 2:2:1:1, in a combination with an aromatherapy with Atlas cedar oil.

EFFECT: integrated exposure in the developed mode provides higher non-specific body resistance to meteorological factors.

2 ex, 3 tbl, 8 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: there are presented: using a compound of formula (1) or its salt for preparing a drug for increasing HIF-1α stabilisation in a cell, as well as for preparing a drug enhancing the immune response in an individual, for preventive management of a wound to avoid an infection, for treatment of the microbial infection, for improvement of efficacy of a vaccine for management of the wound in the individual. What is presented is a pharmaceutical composition containing the above HIF-1α prolyl hydroxylase inhibitor and one or more additives. What is shown is achieving the declared applications by using the new compound of formula (1) with the HIF-1α prolyl hydroxylase (HIFPH2 (EGLN1)) inhibitor. It makes it applicable for treating HIF-1 alpha activity related diseases, conditions and/or syndromes.

EFFECT: preparing the drug for increasing HIF-1α stabilisation in a cell.

26 cl, 20 dwg, 8 tbl, 13 ex

FIELD: medicine.

SUBSTANCE: what is used is a 20% alcoholic tincture (1:10) of medicinal herbs in the following weight proportions: Rhaponticum carthamoides roots and rhizomes - 2, tormentil roots - 1, peppermint leaves - 3. A mouthwash is prescribed before a dentist's appointment for 3-4 days 3 times a day, as well as 10-15 minutes before an impression manipulation.

EFFECT: method provides reducing intensity a gag reflex accompanying dental manipulations.

FIELD: medicine.

SUBSTANCE: what is presented is a method for stimulating the post-traumatic spinal cord regeneration consisting in a single-stage transplantation of human umbilical cord blood mononuclear cells pre-transduced with recombinant adenovirus with a cloned gene of glial derived neurotrophic factor (gdnf), in the damage area.

EFFECT: using the invention enables providing a better outcome of the post-traumatic spinal cord regeneration, reduced length of staying in hospital of patients suffering from a spinal cord injury and improving the patients' quality of life.

1 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to the pharmaceutical industry, particularly to a pharmaceutical composition for dehydration, atrophy and removal of abnormal tissues, and to using it. The pharmaceutical composition for dehydration, atrophy and removal of abnormal tissues contains a composite of an inorganic polymer iron salt as an active ingredient; the composite of the inorganic polymer iron salt is polymer ferrous sulphate silicate (PFSS), or polyferrous silicate chloride (PFSC), or polyphosphate ferrous sulphate (PPFS). Using the pharmaceutical composition consists in preparing the drug for dehydration, atrophy and removal of abnormal tissues.

EFFECT: pharmaceutical composition is effective for dehydration, atrophy and removal of abnormal tissues in treating haemorrhoids, haemangiomas, varicose veins, burns, bleeding traumatic wounds, local wounds caused by chemicals or microorganisms.

9 cl, 12 dwg, 2 tbl, 7 ex

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine and can be used for modification of eating behaviour in a subject. For this purpose peripheral introduction of PYY in an amount, efficient for achieving physiological levels of PYY3-36 in blood, plasma and serum, determined after food intake, is performed; or performed is peripheral introduction of PYY agonist in an amount, efficient for imitation of physiological levels of PYY3-36 in blood, plasma or serum, determined after food intake with modification of eating behaviour, by reducing intake of calories, food consumption or appetite reduction or increase of energy consumption in the subject. Also claimed is application of PYY or its agonist as an active ingredient in production of medication.

EFFECT: group of inventions provides weight reduction in the subject due to reduction of intake of calories, appetite reduction or increase of energy consumption in the subject.

50 cl, 9 dwg, 6 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to chemical-pharmaceutical industry and represents a preparation for involving a mesenchymal stem cell of the bone marrow into peripheral blood from the bone marrow, which is introduced into the blood vessel or muscle and which contains any of components: (a) protein HMGB1; (b) HMGB1 protein-secreting cell; (c) a vector, into which HMGB1 protein-coding DNA is inserted; (d) protein HMGB2; (e) HMGB2 protein-secreting cell; (f) a vector, into which HMGB2 protein-coding DNA is inserted; (g) protein HMGB3; (h) HMGB3 protein-secreting cell; and (i) a vector, into which HMGB3 protein-coding DNA is inserted.

EFFECT: elaboration of the preparation for involving the mesenchymal stem cell of the bone marrow into peripheral blood from the bone marrow.

3 cl, 6 ex, 1 tbl, 14 dwg

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely immunology, and may be used for reducing eosinophil count in a human body. That is ensured by the parenteral administration of approximately 0.01 mg/kg to approximately 0.25 mg/kg of a monoclonal chimeric humanised antibody or a human antibody which binds to IL-5P and contains an immunoglobulin Fc fragment and is fucose-free; the administered antibody reduces the peripheral blood circulating eosinophil count below the detection threshold, and the circulating eosinophil calculation level remains below the detection threshold for approximately 28 days after antibody dosing.

EFFECT: using the given method leads to fast and prolonged reduction of peripheral blood eosinophils.

9 cl, 14 ex, 31 dwg, 1 tbl

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to a method of preventing complications of rhinitis or an influenza-like syndrome. The method of preventing complications of rhinitis or the influenza-like syndrome consists in the following: an isoosmotic ionic sea water-based solution with osmolarity, equal to 250-350 mOsm/kg, is introduced daily into each nostril of patients suffering from rhinitis or the influenza-like syndrome, and at the remission stage in the certain regimens.

EFFECT: increased method efficiency.

9 cl, 13 dwg, 13 tbl, 1 ex

FIELD: medicine.

SUBSTANCE: method involves a dietary therapy, taking mineral water in an amount of 100-150 ml, 3 times a day and exposure to a physical factor. What is used is the Pevzner's diet No. 5. Karachinskaya chloride-hydrocarbonate sodium gas-free mineral water of total mineralisation up to 3 g/dm3, at a temperature of 38-40°C is taken 30-40 minutes before a meal. The physical factor represents a magnetic laser therapy and an EHF therapy. The contact magnetic laser therapy covers three zones sequentially at a frequency of 5 Hz: an epigastric zone and the right and left upper hypochondria along the midclavicular lines, for 4 minutes for each zone within the course of 10 procedures. The EHF therapy involves combined exposure on two projection zones: in the right hypochondrium and on the sternum generated by a broadband noise emitter at an emission frequency of 40-63 GHz, for 20 minutes, every day within the course of 10 procedures.

EFFECT: method provides more effective rehabilitation treatment following endoscopic cholecystectomy ensured by the early integrated therapeutic exposure.

2 ex, 4 tbl

FIELD: medicine.

SUBSTANCE: method involves the intake of low-mineralised low-carbonate sulphate-hydrocarbonate sodium-calcium mineral water of Slavyanovskiy source. The mineral water is taken 45 minutes before meals, in a dose of 3.3 g/kg of body weight per one intake, 3 times a day. That is combined with a partial-load physical activity, dietary therapy No. 5, mineral baths with the above mineral water at temperature 36-37°C, for 15 minutes, every second day; the therapeutic course involves 10 procedures; that is also combined with a dynamic electrical nerve stimulation (DENS) according to the schedule. The therapeutic exposure is segmental at frequency 7710 Hz for 10 minutes. The therapeutic exposure covers a projection of a liver at frequency 10 Hz for 5-10 minutes. The therapeutic exposure covers a projection of a pancreatic gland 77 Hz for 10 minutes and biologically active points (BAPs) GI-4(He Gu) and RP(sang-yin-jiao). The BAP exposure with programmed minimum effective dose (MED) is alternated every second day. The therapeutic course is 10 procedures.

EFFECT: method provides relieving pain and dyspeptic syndrome, improving the functional status of the pancreatic gland, regulating the digestion process and stimulating the adaptive reserves.

3 ex, 4 tbl

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely gynaecology, physiotherapy. A method involves the integrated treatment of the patients with genital endometriosis and hysteromyoma. The treatment involves taking mineral water, observing a biologically programmed light pattern, taking radon baths and radon gynaecological irrigations and small enemas, as well as conducting a laser therapy of biologically active points (BAPs). The patients take carbonated chloride-hydrocarbonate-sulphate sodium-calcium warm Narzan water taken from sources No. 4, No. 7 and No. 24, 3.4 mg per kg 3 times ad day, 40 minutes before meals. The radon baths are taken with the radon concentration of 1.5 kBq/l. The radon gynaecological irrigations and microenemas are performed with the radon concentration of 6.5 kBq/l, temperature 36°C, for 15 minutes within the course of 10-12 procedures. The BAP laser therapy is conducted in an autoresonant mode. The BAPs of anterior median meridian are covered, including: 1-2 (qu-gu), 1-3 (zhong-ji), 1-4 (guan-yuan), 1-5 (shi-men), 1-7 (yin-jiao); renal meridian: R-12 (da-ho), R-13 (qi-xu), R-14 (si-man), R-15 (zhong-zhu), R-16 (huang-shu); bladder meridian: V-31 (shang-liao), V-32 (ci-liao), V-33 (zhong-liao), V-34 (xia-liao); posterior median meridian: T-2 (yao-shu), T-3 (yao-yang-guan), T-4 (min-man), T-5 (xuan-shu). Using the radon baths of the different radon concentrations 'softens' an effect of the absorbed radiation dose on the homeostasis systems and preserves an effect of a high absorbed dose on the genital system. The laser therapy in the autoresonant mode within pathological BAPs improves the accuracy of the exposure on the pathological processes within a target organs.

EFFECT: method prolongs the remission, normalises the hormonal ratios in the remote period.

2 dwg, 4 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to physiotherapy, balneotherapy. Taking baths is realised. Bath includes gas-saturated water, and beer. Saturation with gas is performed by addition of fresh non-filtered beer in ratio 1:10 and supply of air, heated to 25°C from bottom to top. 1/2 part of water, heated to 40°C is poured into bathtub. After that, beer is added and then water, heated to 40°C, in amount of remaining 1/2 part. Bathtub is made from oak with holes.

EFFECT: method increases efficiency of bath realisation due to complex impact on organism with thermal and chemical factors and aeromassage.

FIELD: medicine.

SUBSTANCE: invention refers to medicine, and aims at treating irritable bowel syndrome with diarrhoea. What is used is a low-mineralised sodium hydrocarbonate Abalakhskaya mineral water (AMW) with an faintly alkaline reaction of aqueous medium. The complex therapeutic course makes 21 days including drinking therapy - 18 days, a single drinking dose of AMW of temperature 38-40°C is gradually increased from 50-80 ml to 180-200 ml; the procedures of duodenal drainage are performed with the use of AMW of temperature 37-38°C in the amount of 200 ml of a single dose; for the procedures of intestinal irrigations, AMW is pre-heated to 40-42°C, while a single dose makes 500 ml gradually increased to 800 ml; the procedures of intestinal irrigations are alternated with baths.

EFFECT: method provides higher clinical effectiveness in irritable bowel syndrome, normalised intestinal motility.

2 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely rehabilitation medicine, physiotherapy and urology and may be used for the purpose of rehabilitation of the patients suffering urolithiasis following lithitripsy. That is ensured by the intake of the herbal tea "Veres" containing wild camomile blossom, knotgrass herb, nosebleed herb and horsetail herb, juniper fruits, sage leaves, birch leaves, red bilberry leaves, linseeds taken in equal proportions. The infusion is taken in a dose of 100 ml 3 times a day 30 minutes before meals for 5-7 preoperative days. The common background therapy follows the lithotripsy procedure. That is combined with the additional intake of the herbal tea "Veres" for 10 days following the above procedure and hydrocarbonate sulphate calcium-magnesium mineral water "Kazachinskaya" of mineralisation 1.44g/l for 24 days following lithotripsy. The mineral water "Kazachinskaya" is taken in a dose of 200-250 ml 3 times a day before meals. Further, after the lithotripsy procedure, a projection of the involved kidneys and renal duct is exposed to the apparatus Bemer-3000 at AC field frequency 30-1000 Hz and magnetic field intensity 8.5-100 mcT. The exposure is generated by an intensive contact applicator from 2 fields in the mode-1 (2-4 stages) of 8 minutes. The therapeutic course makes 10 daily procedures. The background therapy is followed by another one-month intake of the herbal tea "Veres", as well as by another exposure to the apparatus "Bemer-3000" at the same parameters of the electromagnetic field. The contact exposure also covers the kidneys and the lower one-third of the renal duct by means of the intensive application from 2-4 fields in the mode-2 (2-4 stages) of 12 minutes. The exposure is daily, two times a day.

EFFECT: method provides reducing the length of calculus fragments discharge following the lithotripsy procedure, improving the clinical and biochemical blood and urine statuses, renal blood flow, treating and preventing the postoperative complications, recovering the immunological responsiveness and antioxidant protection.

4 dwg, 3 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to gastroenterology and represents a method of treating irritable bowel syndrome with constipations with using low-mineralised hydrocarbonate sodium mineral water "Alabakhskaya" (AMW) with a faintly alkaline reaction of the aqueous medium involving the daily three-time drinking of AMW, duodenal drainages with using AMW, intestinal irrigations with using AMW following cleansing enemas, taking toning pine or salt-water baths; the integrated therapeutic course makes 21 day, including an 18-day drinking therapy, a single drinking dose of AMW at temperature 36-38°C is gradually increased from 50-80 ml to 200 ml; the duodenal drainage is conducted with using AMW at temperature 37-39°C in the amount of 200 ml of a single dose; for intestinal irrigations, AMW is pre-heated to 39-40°C, while a single dose makes 500 ml to be gradually increased to 800 ml; the intestinal irrigations are alternated with taking baths.

EFFECT: invention provides higher clinical effectiveness and reduces the length of treatment of irritable bowel syndrome with constipations.

2 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine and aims at treating bile passage dysfunction. What is involved is a 2-staged integrated treatment. At the 1st stage, a diet, sorbents, mineral water, physiotherapy (thermal vibromassage of the area of the gall bladder and liver, or biologically active points) are prescribed. At the 2nd stage, the treatment is prolonged by administering adsorbents in the form of herbal preparations, as well as pelotherapy considering a type of dysfunction.

EFFECT: method enables reducing the length of pain management, prolonging remission or achieving full rehabilitation in children and adolescents suffering bile passage dysfunction and living in environmentally unfriendly regions.

3 cl, 4 ex, 2 tbl

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to physiotherapy, gastroenterology. The method involves dietary therapy No. 5, general pine baths, magnetic laser therapy, intake of mineral water with underlying sparing training regimen followed by transverse galvanisation of the epigastrial area. The transverse galvanisation immediately follows the intake of mineral water between 10 to 11 o'clock. Additionally, the right hypochondrium and sternum are exposed to EHF radiation generated by a broadband noise transducer with a frequency of 40-63 GHz, for 10 minutes per each area, every day; the therapeutic course is 10-12 procedures.

EFFECT: method enables higher clinical effectiveness ensured by using a chronobiological approach to treating the patients for the purpose of relieving the functional disorders of the bile system with underlying increased adaptive capacities of the body.

2 ex, 2 tbl

FIELD: medicinal microbiology, medicine, pharmacy.

SUBSTANCE: invention relates to agents used for enhancing sensitivity of microorganisms to antibacterial preparations. Invention involves applying hydrocarbonate chloride-sodium drinking mineral water "Obukhovskaya" with the total mineralization 1.8-2.2 g/l as an agent for enhancing sensitivity of microorganisms to antibacterial preparations that is used early for treatment of atopic dermatitis and as an agent for treatment of iodine-deficient states. It has been found by method using disks that mineral water "Obukhovskaya" provides enhancing sensitivity of microorganisms to such antibacterial preparations as antibiotics and specific preparations against yeast-like fungi.

EFFECT: improved and valuable agent.

6 tbl, 6 ex

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