Method of production of anti-luteolytic blood - alb, method of treatment and prevention of postpartum obstetric and gynecological diseases in cows

FIELD: veterinary medicine.

SUBSTANCE: method for production of anti-luteolytic blood - AlB is that luteolisate is administered subcutaneously to gelding twice with an interval of 14 days at a dose of 20 ml each, containing parts of the corpus luteum of pregnancy of cows, and after 14 days after the second administration the blood is taken from the jugular vein. The method of treatment and prevention of persistent corpus luteum, subinvolution of uterus and postpartum endometritis in cows comprises at the background of general therapy the use of anti-luteolytic blood that is administered subcutaneously in the neck region twice at a dose of 10 ml each with an interval of 6 days.

EFFECT: use of anti-luteolytic blood promotes the resorption of the corpus luteum of pregnancy and shortens the duration of postpartum involution of genitals that enables to prevent and reduce the time of treatment of ill cows with persistent corpus luteum, subinvolution of uterus and postpartum endometritis.

2 cl

 

The invention relates to the field of veterinary obstetrics, and can be used for the prevention and treatment of obstetric-gynecological diseases in cows.

In the reproductive system in cows after normal delivery, great changes take place. 2-3 hours after childbirth, the uterus is sawsana. The uterus becomes thick, on the surface palpation folds. Caruncula fill almost the entire lumen. Horn, who served as plodovmestylisa, more free. On days 3-5 of the lumen of the cervical canal is narrowed so that only skips 2-3 finger. Lochia in cows in the first bloody days; on days 3-5 of them in the form of thick, turbid, viscous mucus. Then the Fuckers become chocolate color; 8-th day acquire the character of mucus, and for the 10-14th day cease.

After birth the number of cells of the yellow body (Corpus luteum of pregnancy gradually begins to decrease. Vessels, richly penetrating yellow body, with a decrease in its total approach, forming a dense network. Gradually these vessels also undergo degeneration, turning into soedinitelnotkannye strands. The involution of the yellow body of pregnancy ends to the 16-th day of the postnatal period and is accompanied by intensive growth of follicles [2].

In optimal conditions, feeding, care, maintenance and proper use of natural postpartum who evolucia genital organs of cows ends up on average 3 weeks after birth, their ovaries are intensively developing in the egg follicles, produce estrogen (follicular hormone), and breeding may again come fertilization and pregnancy [9].

Because of the inadequate feeding and poor detention conditions for highly productive cows, especially in the absence of walks in the stall period, the process of involution continues until 40 days or more, these cows often there is a lack of sexual cycles (anaphrodisia)and by rectal examination found luteum in the ovaries [3, 8].

Remaining after the birth of a yellow body supports the body with a high level of progesterone. This hormone inhibits the growth of follicles and ovulation, delays postpartum involution [2].

D. Hammond (1955) indicates that in cows under the influence of the follicular hormone, increases the resistance of the uterus to infection and the risk of infection when the penetration of bacteria into the uterus is much smaller than in cows under the influence of hormone yellow body. He explains this by the fact that evolved under the influence of estrogen mucus creates a barrier for microbes, while eye-catching under the influence of progesterone, the uterine milk is a good medium for them. In addition, estrogenic hormones increase the protective function of the uterus by reinforced what I leukocyte reaction [5].

Thus, the violation of resorption of the yellow body of pregnancy in the postpartum period in cows disturbed antimicrobial and contractile function of the uterus, which contributes to the development of subinvolution of the uterus and postpartum endometritis, there is a long violation of the sexual cycles and infertility[1, 2, 3, 4, 5, 6, 7, 8].

In inflammatory processes in the uterus disrupted production of prostaglandin F2a, because what happens regression yellow body, which is delayed for a long time. Therefore, when studying cows, sick subinvolution of the uterus and postpartum endometritis, often in the ovaries detected yellow body.

Hence the main task of the modern integrated prevention subinvolution of the uterus, postpartum endometritis and persistent luteum in cows is the use of drugs for early resorption yellow body, restoring tone and contractile function, stimulation of regeneration of epithelial tissues in the uterus, increasing the overall resistance of the organism [3, 5].

The purpose of the invention is the generation and application of antisocially blood (Ala), which has therapeutic and preventive action aimed at improving the body's defenses, to accelerate the resorption of the yellow body of pregnancy and involution of the uterus in cows.

The home is jaimoe invention meets the criterion of "novelty", since the use antisocially blood (Ala) for the prevention and treatment of cows with persistent yellow body, subinvolution of the uterus, postpartum endometritis is not known.

The claimed invention meets the criterion of "significant differences", as an additional effect - profilactics postpartum obstetric-gynecologic diseases and reduces the treatment time sick cows.

To obtain antisocially blood (Ala) is a young healthy gelding, which subcutaneously injected luteolysis cows, containing parts of the yellow body of pregnancy at a dose of 20 ml, twice with an interval of 14 days. The introduction of a foreign agent promotes the formation in the body gelding biologically active substances with directed action, accelerating the absorption of the yellow body of pregnancy and involution of the uterus of cows. 14 days after the second injection of luteolata the gelding take blood from the jugular vein and add an anticoagulant.

The known method of applying prostaglandinsdanger drugs (magestrofan estrofan, dinoprost, hansaplast and others) when persistent yellow body and cysts luteum in cows, but these drugs do not have General-stimulating action. Studies have shown that therapeutic effect of magestrofana in the postpartum period yields e is the efficiency of use antisocially blood (Ala).

There is a method of using the drug KGK when persistent yellow body in cows, but it contains only gonadotropic hormones and has no purposeful action aimed at the absorption of the yellow body.

Used autohemotherapy cows with persistent yellow body - two intramuscular injections of 50-100 ml with an interval of 5 days, has only subsectimeorig effect and does not contribute to the resorption of the yellow body [3, 5].

However antisocially blood (Ala) compared with conventional Autocraft in addition to General-stimulating also has a specific action aimed at strengthening resorption yellow body of pregnancy, which accelerates postpartum involution of the genital organs. The efficiency of Ala is enhanced by the background of the use of uterotonic drugs.

Antisocially blood (Ala) is introduced to stimulate postpartum involution of the genital organs fresh cows and prevention of postpartum obstetric-gynecologic diseases (subinvolution of the uterus, postpartum endometritis, persistent yellow body) subcutaneously in the neck twice with 10 ml immediately after removal of the fetus and after 6 days.

With care to the persistent yellow body, subinvolution of the uterus, postpartum endometritis cows antisocially blood (Ala) administered subcutaneously in the neck of the double is but 10 ml, with an interval of 6 days, on the background of therapy.

Tested antisocially blood (Ala), on the background of complex treatment of sick cows with persistent yellow body, subinvolution of the uterus, postpartum endometritis (according to 5 sick animals) showed a high therapeutic efficacy.

When applying antisocially blood (Ala) from prevention to 20 fresh cows persistent yellow body, subinvolution of the uterus and postpartum endometritis they were not observed. The experimental cows were marked shortening of the period of excretion lohii and involution of the uterus.

Use antisocially blood (Ala) accelerates resorption yellow body and reduces the duration of postpartum involution of the genital organs, which allows prevent and reduce the time of treatment of cows with persistent yellow body, subinvolution of the uterus and postpartum endometritis.

Sources of information

1. Veterinary obstetrics and gynecology. Edited by Prof. Gagarinova. - L., "Kolos" (Leningrad. separa-tion), 1977. - S-361.

2. Veterinary obstetrics, gynecology and bioengineering breeding / Apostolescu, Vshield, Viamichelin andetc.; Edited Viamichelin and Megerramova. - 7th ed., revised and enlarged extra - M.: Kolos, 2000. - S-317.

3. Goncharov VP, Karpov V.A. Prevention and treatment of gynecological diseases is any cows. - 2nd ed., Rev. and supplementary): Rosagropromizdat, 1991. - 190 S.

4. Ermachenko NN. Obstetrics and gynecology farm animals. Ed. 2nd, Rev. and extra - L., "Kolos" (Leningrad. separa-tion), 1976. - S-182.

5. Sankowski IVAN Prevention and treatment of obstetric and gynecological diseases in cows. - Ufa, Bashkir publishing house, 1982. - 232 S.

6. Logvinov SHOSTAKOVICH Pregnancy and parturition in cows. - K., "Harvest", 1975, S-229.

7. Workshop on obstetrics, gynecology and bioengineering of animal reproduction./ Viamichelin, Mgerasimov, Vphone and others - M.: Colossus, 2004. - S-168.

8. Titova Century and other effects on the involution of the uterus in cows quantum method.// Titova Century, Nasibov F., Baitlesov E., Katukov Century, Vlasova,/ Dairy and beef cattle, No. 1, 2006. - P.24-25.

9. Shipilov Century Physiologically Foundation for the prevention of infertility in cows, M., 1977.-288 C.

1. The method of obtaining antisocially blood - Ala, characterized in that is used gelding, who twice with an interval of 14 days subcutaneously injected luteolysis at a dose of 20 ml, containing parts of the yellow body of pregnancy, cows, and 14 days after the second injection, blood is taken from the jugular vein.

2. Method for the treatment and prevention of persistent yellow body, subinvolution of the uterus and postpartum endometritis in cows, including on the background of therapy application antisocially blood - Ala, great for the present, however, that as a drug used antisocially blood - Ala, which is injected subcutaneously in the neck twice 10 ml with an interval of 6 days.



 

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