Method for describing nature of arrested sexual development in boys in puberty with growth retardation |
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IPC classes for russian patent Method for describing nature of arrested sexual development in boys in puberty with growth retardation (RU 2462720):
 Diagnostic technique for idiopathic nasal breathing irregularities in pregnant women / 2456604
Blood serum of a pregnant woman is examined for the oestradiol concentration by enzyme-linked immunosorbent assay. Observing the oestradiol concentrations exceeding normal values according to weeks of gestation in 1.4 times and more enables stating idiopathic nasal breathing irregularities accompanying a period of pregnancy.
Method for prediction of level of efficiency of reduction of manifestation severity of atopic dermatitis / 2453851
Pre-therapy blood plasma is analysed for immunoglobulin E, adrenocorticotrophin and endorphin, the index SCORAD dynamics is determined by formula: Dsk=1.34147-0.000820741*IgE-0.00382642*ACTP+0.0209401*endorphin wherein IgE is the level of acute blood plasma immunoglobulin E mIU/ml; ACTP is the level of acute blood plasma adrenocorticotrophin ng/l. If observing the Dsk value exceeding 1.18, a prognosis of improving clinical dynamics of recovery is favourable; the conventional therapy is considered to be sufficient. The Dsk value being equal to 1.18 or less, the improving clinical dynamics of recovery is unfavourable, the intensified therapeutic scheme for atopic dermatitis is considered to be preferential.
 Method for identification and classification of 3-oxosteroids and their metabolites in doping test of sportsmen / 2452967
Blood plasma is examined for the presence and the position of double bonds and the related differences in structural characteristics. Common and examined steroids are chemically modified by a carboxyl group (oximes); their mass spectra are read out and recorded; characteristic ions (lc) and neutral loss (Do) are specified in the mass spectra. The specified lc and Do values are related to those specific for common 3-oxosteroid oximes by the absolute value. Herewith it is only the similar lc and Do values from both sides differing by 0.3% and less that are taken into consideration; the comparison results are used to identify 3-oxosteroid oximes.
Method of antenatal prediction of consequences of perinatal lesions of nervous system in children / 2449287
Clinical examination of pregnant woman is carried out, additionally performed are Stange's and Hench's functional respiratory tests in early period at terms of 11-19, 21-29, 31-39 weeks of gestation period, also in dynamics in I and III trimesters determined are indices of blood hormonal spectrum: T4, TSH, T3, cortisole, vitamin E, insulin, indices of lipid peroxidation and antioxidative blood activity, blood indices - hemoglobin, platelets, total protein, fibrinogen. Analysis of risk factors is carried out, their gradations and numerical values are determined and prognostic coefficients S1 and S2 are calculated by formulas. If S1>S2, presence of moderate or severe CNS lesion in children at the age of 4 is predicted. If S1<S2, presence of light degree of severity, or absence of consequences of CNS lesion in children at the age of 4 is predicted.
Method for prediction of dysthyroidism / 2446401
Method involves woman's pre-delivery blood serum examination for nitrogen oxide and relaxin that is followed by calculation of the NO/relaxin relation. If the relation is 3.6 and less, dysthyroidism is predicted.
Method of predicting development of cerebral metastases in case of lung cancer in women / 2439579
In women in tissue of lung malignant tumour after radical surgery in pulmonectomy volume and in intact lung tissue, obtained from ablated from lung section of the same lung, level of progesterone is determined. If it reduces in tumour in 5 times and more relative the level of progesterone in intact lung tissue, development of cerebral lung cancer metastases in women within the term from 3 to 8 months is predicted.
Method of diagnosing androgenic deficiency / 2439578
In blood serum bioavailable testosterone fraction bound to albumin is determined. If its value is lower than 185.7 pg/ml, disease is diagnosed.
 Method of predicting survival potential of patients with malignant gliomas / 2439577
In patient's urine content of 6-sulfatoximelatonin is determined. If determined content of 6-sulfatoximelatonin after operation before complex treatment equals 292.7 nmol/ml survival to 2.3±0.5 months is predicted, if 22.4 nmol/ml is determined, survival for more than 12 months is predicted. If after chemical therapy determined content of 6-sulfatoximelatonin equals 268.2 nmll/ml, predicted survival time equals to 2.1±0.6 months, if content is 32.8 nmol/ml - more than 12 months. If after a month after treatment determined content of 6-sulfatoximelatonin equals 479.3 nmol/ml predicted is survival for 1.2±0.5 months, in case of 37.4 nmol/ml - survival for more than 12 months.
Method for prediction of cervical cancer metastases / 2436102
In 10-14 days following a surgical removal of a tumour in a patient, daily urine is analysed for sex hormones: oestradiol and pregnandiol. Then, they are related to each other. If the value exceeds 0.8, the onset of metastases or a recurrent disease for the following one and a half or two years is predicted. If the relation is less than 0.8, a metastases-free and recurrence-free period for more than 8-10 years is predicted.
Method of predicting state of fertility in women of reproductive age with uterus myoma / 2433411
At lutein phase of menstrual cycle concentrations of 2-hydroxyestrone 16α - hydroxyestrone in urine, concentration of progesterone in blood serum are determined. Then, canonical value is calculated by formula: K=4.23-0.04×A+0.0016×B-0.18×C, where A is concentration of progesterone in blood serum on 20-21 days of menstrual cycle (lutein phase) (nmol/l), B - concentration of 2-hydroxyestrone in urine (nmol/l), C - concentration of 16α - hydroxyestrone in urine (nmol/l). If K is higher than -0.175, infertility is predicted, if K is lower than -0.175 - safe fertility.
Method for differential diagnostics of mammary diseases in men / 2244308
The present innovation deals with biochemical trials: before the onset of therapy in men one should detect blood content of thyroid hormone - free thyroxine - and at its level being 10.3-12.9 pmol/l one should diagnose mammary cancer, at the level of free throxine being 18.7-31.0 pmol/l - one should predict gynecomastia. The method enables to detect the direction of pathological process and carry out due correction of therapy tactics in men with either gynecomastia or mammary cancer.
Method for predicting the delay of intrauterine fetal development / 2246733
The method deals with studying blood serum of pregnant woman to detect the content of insulin-like growth factor (IGF) and vascular-endothelial growth factor (VEGF) and calculate the coefficient of their ratio: at its value being equal to 28.5 and lower it is possible to diagnose the delay of fetal development.
Method for differential diagnostic of chronic hepatitis and hepatic cirrhosis / 2254577
Thyroglobulin content is determined in blood serum using enzyme immunoassay. When thyroglobulin level is increased by 2 times and more compared in contrast with normal one chronic hepatitis is diagnosed, and when thyroglobulin level is decreased by 1.5-2.5 times in contrast with normal one hepatic cirrhosis is diagnosed.
Method for evaluating combined schizophrenia treatment based on atypical antipsychotic drugs and rations and electroconvulsive shock therapy / 2256181
Method involves determining dehydroepiandrosterone sulfate concentration in blood serum. Its growth above 30% when compared to the initial one being observed, treatment efficiency is determined as negative.
Method for diagnosing obliterated forms of congenital suprarenal gland cortex hyperplasia / 2261447
Method involves applying high effectiveness liquid chromatography for determining cortisol, cortisone 11-deoxycorticosterone, 11-deoxycortisone concentration in blood and free cortisol and free cortisone excretion with urine. Ratios of F/E and FF/FE are calculated, where F is the cortisol level in blood; E is the cortisone level in blood; FF is the free cortisol excretion with urine and FE is the free cortisone excretion with urine. The cortisol level in blood not exceeding norm and at least two of three signs: F/E ratio reduction by 25% and more, FF/FE ratio reduction by 25% and more, free cortisol excretion with urine being equal to 25% and more, obliterated forms of congenital suprarenal gland cortex hyperplasia is diagnosed. Corticosterone level in blood growing by 50% and higher, 21-hydroxylase defect is considered to be the case. 11-deoxycorticosterone and/or 11-deoxycortisone concentration in blood being et or greater than 50%, 11β-hydroxylase defect is considered to be the case.
 Method for diagnosing atrophic gastritis cases / 2262706
Method involves making pepsinogen 1, gastrin and Helicopter pylori infection marker combinations analysis and making input of the obtained results into data processing means comprising operation system, means for receiving, transmitting and processing data. The mentioned data processing means is usable for comparing the measured concentration value of a substance under study to a threshold value associated to the substance under study and producing information as a response to comparison results and additionally to other entered data. A set and software are used for implementing the method.
Method for predicting relapse of mammary cancer / 2263319
In the course of surveying in menopausal women after complex therapy one should state the development of mammary cancer at decreased ratio of estriol concentration to the sum of estrone and estradiol urinary concentrations from 1.68±0.23 in relapse-free patients up to 0.74±0.12 - in patients living without relapses for less than a year, up to 0.65±0.13 in patients living without relapse from 2 up to 6 years and up to 0.50±0.10 in patients with relapse-free period from 6 to 10 years. The innovation provides pre-clinical detection of mammary cancer relapse.
Method for predicting fetoplacental insufficiency in pregnant women with thyroid diseases / 2263919
Except detecting placental lactogen in blood serum one should study the content of alphafetoprotein. At placental lactogen content being below 75% against the norm and content of alphafetoprotein below 70% against the norm it is possible to conclude upon availability of fetoplacental insufficiency.
Method for predicting cholecystitis and cholelithiasis / 2263920
While diagnosing cholecystitis and cholelithiasis due to ultrasound testing one should additionally study blood plasma and bile to detect there the content of prostaglandins PGE2 and PGF2α. At PGE2/PGF2α ratio in blood plasma being equal to 6 and more, and, also, at decreased level of biliary cholecystokinin-pancreosimin by 38% and more, biliary PGE2 by 59% and more and increased level of biliary prostaglandin PGF2α by 5.9 times and more against the norm one should diagnose chlecystitis and cholelithiasis. The innovation enables to detect the above-mentioned diseases at earlier stage.
Method for predicting powerless labor in pregnant nodular goiter surgically treated on goiter occasion during pregnancy under medical supervision / 2273456
Method involves determining thyroid gland node diameter and thyrotropic hormone by applying ultrasonic examination approach. Histological examination is carried out with conclusion concerning morphologic nature being obtained like nodular colloid proliferating goiter or thyroid gland adenoma. Diagnostic index Σ is calculated from formula Σ=0.49*K1+0.07*K2-0.5*K3+1.76*K4-1.53, where K1 is the thyroid gland node diameter; K2 is the TTH concentration; K3 is the nodular colloid proliferating goiter index equal to 1 or 0; K4 is the thyroid gland adenoma index equal to 1 or 0. Diagnostic index Σ being less than zero, conclusions concerning powerless labor threat is to be drawn.
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FIELD: medicine. SUBSTANCE: examination results are used to detect boys with the absence or insufficiency of blood concentrations of at least two of three hormones (luteinising hormone, follicle-stimulating hormone, total testosterone) to be used for the clinical course of transcranial magnetic therapy. The concentration of all hormones are evaluated in 1-1.5 months, and if observing increase of the concentrations of at least two hormones, including testosterone by min. 25% from the initial values, a functional nature of arrested sexual development is stated. If observing no increase or increase of the concentrations of two hormones, including testosterone by max. 25% from the initial values, an organic nature of arrested sexual development is stated. EFFECT: lower invasiveness of the method for describing the nature of arrested sexual development in boys in puberty suffering growth retardation. 1 tbl, 3 ex
The invention relates to medicine, namely to endocrinology, neurology and physiotherapy, and can be used to determine the nature of the delay of sexual development in boys during puberty with growth retardation. A known method for the diagnosis of disorders of puberty for boys based on the content of testosterone in blood plasma (Starikov N.T. basis of clinical andrology. - M., 1973, p.3). However, the known method detects only forms of abuse, due to the reduction of functional activity of the testes, and is not possible to determine violations of puberty, caused by insufficient sensitivity of specific receptor systems androgen-dependent organs. There is also known a method of identifying disorders of sexual development in boys by determining the activity of absorption of N3-testosterone skin cells in the genital area. On a variance of indices of age diagnosed violation of puberty (USSR Author's certificate No. 1000021, IPC AB 10/00. Publ. 28.02.1983, bull. No. 8). The disadvantage of this method is its invasiveness and lack of information, because the definition of H3testosterone makes no assumptions about the nature of disorders of sexual development. Closest to the proposed its the technical essence is a method of differential diagnosis of functional delay puberty in boys include a definition in their blood concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and total testosterone (T), and compare the obtained values with standard values for children in this age group and a functional test to assess gonadotropic function of the pituitary gland in patients with impaired timing of puberty. To test use diferelin 0.1 mg (triptorelin; Beaufour Ipsen International) - synthetic Decapeptide, a structural analogue of gonadotropin-releasing hormone prolonged action. Collection of samples of blood after the injection is carried out before and after 1, 4 and 24 hours after subcutaneous injection. About puberty character secretion of gonadotropins shows the level of luteinizing hormone, greater than 10 mIU/L. lower value indicates a delay of pubertal development without revealing his character (Ivan Dedov, Gasolinetm. Rational pharmacotherapy of diseases of the endocrine system and metabolic disorders. A guide for practitioners. - M., 2006, s). The disadvantage of this method is its high invasiveness (fourfold blood sampling during the day), mandatory for hours near the laboratory between samples, the inability to determine the nature of the delay, poliwag the development in boys during puberty with growth retardation. Task to be solved by the claimed invention is directed, is to reduce the invasiveness of the method and determination of the nature of the delay of sexual development in boys during puberty with growth retardation. The technical result is to stimulate the function of the hypothalamic-pituitary system, which is responsible, in particular, hormonal profile. The problem is solved in that in the method of differential diagnostics of functional delay puberty in boys, which includes the determination in their blood concentrations of luteinizing hormone, follicle-stimulating hormone and total testosterone, and compare the obtained values with standard values for children of this age group, according to a survey distinguish the boys from the absence or insufficiency in their blood concentrations of at least two hormones, including testosterone, and hold them rate transcranial magnetic therapy (CRT) by affecting the brain daily for 10-12 minutes running alternating magnetic field with a frequency of 50-100 Hz bitemporal scanning the mode with frequency field scanning 8-12 Hz when the value of the magnetic induction 15-20 MT, a course of 10 treatments. Then after 1-1,5 month re-determine the concentration of these hormones: LH, FSH, T, and in case of an increase to the of ncentrate, at least two hormones, including testosterone, not less than 25% from the original values make a conclusion about the functional nature of the delay of sexual development, and in the absence of enhancing or increasing concentrations of the two hormones, including testosterone, less than 25% from the original values - about the organic nature of the delay of sexual development. The course transcranial magnetic therapy by bitemporal effects on the brain daily for 10-12 minutes running alternating magnetic field improves blood circulation and nutrition of the relevant brain structures. The application running alternating magnetic field with a frequency of 50-100 Hz in the scan mode with a scan rate field 8-12 Hz when the value of the magnetic induction 15-20 MT optimizes transcranial impact for children of this age, which normalizes the function of the hypothalamic-pituitary system, the blood circulation in the vessels of the brain and the power of his tissues, accompanied by improvement in clinical and hormonal parameters, i.e. has a restorative effect on the course of puberty in boys with delayed growth. The use of magnetic induction value of 15-20 MT experimentally substantiated and is the optimal value for children in this age group. When using the smaller C is acene the desired effect of transcranial magnetic therapy in children is not achieved. When the values of the magnetic induction exceeding 20 MT, there is a risk of damage of brain tissue due to spasm of the vessels, as a response to overly aggressive effect. The interval of 1-1 .5 months for re-determination in blood boys concentrations of hormones associated with the delayed action of magnetic fields on the structure of the brain and the peculiarity of the formation of the responses from the point of view of the production of hormones. According to the follow-up examination, the inventors found that increasing concentrations of at least two hormones, including testosterone, not less than 25% from the original values indicates the functional character of delayed sexual development, and the lack of improvement or increasing concentrations of the two hormones, including testosterone, less than 25% from the original values - about the organic nature of the delay of sexual development. The method is as follows. Examine boys puberty with growth delay by determining in their blood concentrations of hormones: LH, FSH and T, for example, enzyme-linked immunosorbent assay using a test kit: follicle-stimulating hormone (FSH IRMA), luteinizing hormone (LH IRMA) and other Then compare the obtained values with standard values for the children of this age group and survey results distinguish the boys from the absence or insufficiency in their blood concentrations, at least two hormones, including testosterone. Teach these boys transcranial magnetic therapy by influencing traveling magnetic field frequency of 50-100 Hz bitemporal in the scanning mode when moving field synchronously on both sides of the temporal lobes to the occipital region with a scanning frequency of 8-12 Hz. After 1-1,5 month re-determine the concentration of these hormones and the results of the survey are judged on the nature of the delay of sexual development. I.e. in the case of increasing concentrations of at least two hormones, including testosterone, not less than 25% from the original values conclude that the presence of boys in the functional nature of the delay of sexual development. In the absence of enhancing or increasing concentrations of at least two hormones, including testosterone, less than 25% from the original values conclude that the presence of boys organic nature of the delay of sexual development. The method is implemented at the Department of propaedeutics of children's diseases, pediatric endocrinology and diabetology, Saratov State medical University n.a. Viethumble. A survey of 67 boys 13-14 years with stunting on a single plan, which included the assessment of complaints, identifying the stage of sexual development according to Tanner, the carrying out of hormonal research is Avani: determination of serum LH, FSH and So On initial examination in the pubertal age main complaint was delayed growth and sexual development: the average value of the SDS growth amounted to 1.2±0,7; sexual development corresponded to the 1st stage Tanner. Levels of sex hormones corresponded populartity values: average value of total testosterone there were 1.2±0.07 nmol/l, LH=1,4±0,2 mIU/l, FSH=1,7±0.4 mIU/L. To determine the nature of the delay puberty boys was applied transcranial magnetic therapy using the apparatus "AMO-ATOS" with the prefix "Headband" (manufacturer: OOO "TRIM" Saratov), representing two emitter traveling magnetic field prismatic shape. The magnetic field was carried out in running mode with a frequency of 50-100 Hz and a frequency field scanning 8-12 Hz when the value of the magnetic induction 15-20 MT daily for 10-12 minutes, the course is 10 sessions. Boys with growth retardation randomly were divided into two groups: 1st group (35 people), which was used CRT and a control group (32 persons) - boys who did not receive CRT (placebo: emitters during the procedure were turned off). The results were evaluated through 1-1,5 month after CRT. According to the survey results patients of the 1st group were divided into two subgroups (see table): 1A - 28 boys where REP is Pnom determining the levels of sex hormones was observed an increase on average by 25% or more from the original values, and 1B - 7 boys who have indicators of sex hormones has not changed by more than 10%. In the control group-placebo (32 boy) indicators of sex hormones increased by no more than 25% from the original values. Thus, 28 boys 1A group conducted using transcranial magnetic therapy has been identified functional nature of the delay of sexual development, which allowed unlike the prototype method to eliminate additional invasive procedures, long stay near the laboratory between samples. No reliably positive results in children of the control group-placebo who were administered placebo treatments, demonstrates the direct effect of magnetic field on the brain structures and excludes positive placebo effect.
To confirm the identified organic pathology (i.e. non-functional) 7 boys 1B group, have not recorded a positive performance of transcranial the th magnetotherapy (increase sex hormone levels did not exceed 25%), was conducted stimulation test with diphereline on the prototype method, the results of which have 6 children stimulated LH did not exceed 10 mIU/L. these patients was diagnosed gipogonadotropny hypogonadism (organic delayed sexual development). With repeated follow-up examination after one year from the beginning of the survey in 25 (82,3%) boys 1A group revealed positive dynamics of the flow of puberty and the increase of sex hormones. This proves that the increasing concentrations of at least two hormones, including testosterone, not less than 25% from the original values indicates the functional character of delayed sexual development, and the lack of improvement or increasing concentrations of the two hormones, including testosterone, less than 25% from the original values - about the organic nature of the delay of sexual development. Example 1. Patient A., 14.5 years. The boy was admitted to the Department of propaedeutics of children's diseases, pediatric endocrinology and diabetology, Saratov State medical University n.a. Viethumble complaining of delayed growth and sexual development. In the initial examination was delayed physical development: growth=140 cm, weight=32 kg, BMI=16,3 kg/m2, SDS growth=-2, SDS BMI=-1. When assessing sexual development identified coubertain the e size of the genital organs: the volume of gonads 3,5/3 ml, penis length 4 cm, sexual development corresponded to the 1st stage of puberty by Tanner (P1G1). When hormonal examination revealed low values of sex hormones: LH=1,0 mIU/l, FSH=1,6 mIU/l, T=1.7 nmol/L. To determine the nature of the delay of puberty, the patient was applied transcranial magnetic therapy using the apparatus "AMO-ATOS" with the prefix "Headband" (registration certificate №SDF 2009/04781). The exposure was carried out with an alternating magnetic field in the running mode with a frequency of 50 Hz and a frequency field scanning 8 Hz when the value of magnetic induction of 15 MT daily for 11 minutes, a course of 10 treatments. 1 month after the holding magnet therapy re-examined the levels of sex hormones, which amounted to: LH=1,27 mIU/l, FSH=2,02 mIU/l, T=2.21 nmol/L. According to the results of hormonal inspection revealed an increase in LH 27%, FSH on 26,25%, T by 30%. Thus, increasing the concentration of the two hormones of the three investigated, namely LH and T, more than 25% testified about the functional nature of the delay of sexual development. Long-term results during the follow-up examination of the patient after 1 year showed a significant improvement in physical and sexual development: growth=148 cm, weight=37 kg, BMI=16,9 kg/m2, SDS growth=-1,6; SDS BMI=of 0,95; the volume of gonads 4,5/5 ml, the length of a sexual member is=4.5 cm, sexual development was consistent with stage 2 of puberty by Tanner (P2G2). Hormonal examination revealed a significant increase of the values of sex hormones: LH=a 1.8 mIU/l, FSH=to 2.5 mIU/l, T=4.3 nmol/L. Thus, the trigger to stimulate hormonal profile this boy survived for quite a long time, which has led to improved levels of physical and sexual development and confirmed the presence of a functional nature, delay of sexual development. Example 2. Patient M., aged 14. The boy was admitted to the Department of propaedeutics of children's diseases, pediatric endocrinology and diabetology, Saratov State medical University n.a. Viethumble complaining of delayed growth and sexual development. The examination detected a delay in physical development: growth=138 cm, weight=34 kg, BMI=17.8 kg/m2, SDS growth=-2,2; SDS BMI=-0,16. When assessing sexual development identified daubentonia the sizes of genitals: the volume of gonads 3/3 ml, penis length 4 cm, sexual development corresponded to the 1st stage of puberty by Tanner (P1G1). When hormonal examination revealed low values of sex hormones: LH=0,6 mIU/l, FSH=1,3 mIU/l, T=0.83 nmol/L. The patient was held transcranial magnetic therapy using the apparatus "AMO-ATOS" with the prefix "Headband". The impact has been displaced is owned by a magnetic field in a running mode with a frequency of 100 Hz and a frequency of the scan field 12 Hz when the value of the magnetic induction 20 MT daily for 10 minutes, the course is 10 sessions. 1 month after the holding magnet therapy re-examined the levels of sex hormones, which amounted to: LH=0,75 mIU/l, FSH=1,66 mIU/l, T=1.2 nmol/L. According to the results of hormonal inspection revealed an increase in LH 25%, FSH on 27,69%, T 44,58%. Thus, increasing the concentration of the two hormones of the three investigated, namely LH and T, more than 25% testified about the functional nature of the delay of sexual development. Long-term results during the follow-up examination of the patient after 1 year showed a significant improvement in physical and sexual development: growth=142 cm, weight=40 kg, BMI=19.8 kg/m2, SDS growth=-1,43; SDS BMI=+0,8; the volume of gonads 4,5/5 ml, penis length=4.5 cm, sexual development corresponded to stage 2 of puberty by Tanner (P2G2). Hormonal examination revealed a significant increase of the values of sex hormones: LH=1,2 mIU/l, FSH=2,2 mIU/l, T=1.9 nmol/L. Thus, this method of determining the functional delay sexual development simultaneously adjusts functional delay sexual development through an additional course of treatment. Example 3. Patient O., 13.5 years. The boy was admitted to the Department of propaedeutics of children's diseases, pediatric endocrinology and diabetology, Saratov State medical University n.a. Viezu who's complaining of delayed growth and sexual development. The examination detected a delay in physical development: growth=148 cm, weight=35 kg, BMI=15,98 kg/m2, SDS growth=-1,14; SDS BMI=-0,96. When assessing sexual development identified daubentonia the sizes of genitals: the volume of gonads 3/3 ml, penis length 3 cm, sexual development corresponded to the 1st stage of puberty by Tanner (P1G1). When hormonal examination revealed low values of sex hormones: LH=0,1 mIU/l, FSH=1,8 mIU/l, T=1.2 nmol/L. To determine the nature of the delay of puberty, the patient was held transcranial magnetic therapy using the apparatus "AMO-ATOS" with the prefix "Headband". The exposure was carried out with an alternating magnetic field in the running mode with a frequency of 50 Hz and a frequency field scanning 8 Hz when the value of magnetic induction of 15 MT daily for 11 minutes, a course of 10 treatments. 1 month after the holding magnet therapy re-examined the levels of sex hormones, which amounted to: LH=0,1 mIU/l, FSH=1,9 mIU/l, T=1,34 nmol/L. According to the results of hormonal research, improved hormonal profile (T, LH, FSH) does not exceed 25%, which was indicative of organic pathology in this boy. To confirm the organic nature of the delay of sexual development (identify gipogonadotropny hypogonadism) patient was held diphereline sample (0.1 mg). After 1 hour, the level art is melirovanie LH corresponded to 3.3 mIU/l, after 4 hours and 4.4 mIU/l, 24 hours to 2.5 mIU/L. I.e. the lack of increase in luteinizing hormone in the background stimulation diphereline confirmed organic nature of the delay of sexual development. Long-term results during the follow-up examination of the patient after 1 year showed no increase in hormone levels and improve clinical data. In connection with which the child was assigned to hormone replacement therapy. Thus, the above examples confirm that the claimed method allows effective to determine the nature of the delay of sexual development in boys during puberty with growth retardation. The method of determining the nature of the delay of sexual development in boys during puberty with growth retardation, including examination by defining in their blood concentrations of luteinizing hormone, follicle-stimulating hormone and total testosterone, comparing the obtained values with standard values for children of this age group, characterized in that the survey distinguish the boys from the absence or insufficiency in their blood concentrations of at least two hormones, including testosterone, and hold them rate transcranial magnetic therapy by affecting the brain structures daily 10 -12 min running an alternating magnetic field with a frequency of 50-100 Hz bitemporal scanning the mode and frequency field scanning 8-12 Hz when the value of the magnetic induction 15-20 MT, the course is 10 sessions, then after 1-1,5 month re-determine the concentration of these hormones, and in the case of increasing concentrations of at least two hormones, including testosterone, not less than 25% from the original values make a conclusion about the functional nature of the delay of sexual development, and in the absence of enhancing or increasing concentrations of the two hormones, including testosterone, less than 25% from the original values - about the organic nature of the delay of sexual development.
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