Diagnostic technique for idiopathic nasal breathing irregularities in pregnant women |
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IPC classes for russian patent Diagnostic technique for idiopathic nasal breathing irregularities in pregnant women (RU 2456604):
      
Method for prediction of level of efficiency of reduction of manifestation severity of atopic dermatitis / 2453851
Pre-therapy blood plasma is analysed for immunoglobulin E, adrenocorticotrophin and endorphin, the index SCORAD dynamics is determined by formula: Dsk=1.34147-0.000820741*IgE-0.00382642*ACTP+0.0209401*endorphin wherein IgE is the level of acute blood plasma immunoglobulin E mIU/ml; ACTP is the level of acute blood plasma adrenocorticotrophin ng/l. If observing the Dsk value exceeding 1.18, a prognosis of improving clinical dynamics of recovery is favourable; the conventional therapy is considered to be sufficient. The Dsk value being equal to 1.18 or less, the improving clinical dynamics of recovery is unfavourable, the intensified therapeutic scheme for atopic dermatitis is considered to be preferential.
 Method for identification and classification of 3-oxosteroids and their metabolites in doping test of sportsmen / 2452967
Blood plasma is examined for the presence and the position of double bonds and the related differences in structural characteristics. Common and examined steroids are chemically modified by a carboxyl group (oximes); their mass spectra are read out and recorded; characteristic ions (lc) and neutral loss (Do) are specified in the mass spectra. The specified lc and Do values are related to those specific for common 3-oxosteroid oximes by the absolute value. Herewith it is only the similar lc and Do values from both sides differing by 0.3% and less that are taken into consideration; the comparison results are used to identify 3-oxosteroid oximes.
Method of antenatal prediction of consequences of perinatal lesions of nervous system in children / 2449287
Clinical examination of pregnant woman is carried out, additionally performed are Stange's and Hench's functional respiratory tests in early period at terms of 11-19, 21-29, 31-39 weeks of gestation period, also in dynamics in I and III trimesters determined are indices of blood hormonal spectrum: T4, TSH, T3, cortisole, vitamin E, insulin, indices of lipid peroxidation and antioxidative blood activity, blood indices - hemoglobin, platelets, total protein, fibrinogen. Analysis of risk factors is carried out, their gradations and numerical values are determined and prognostic coefficients S1 and S2 are calculated by formulas. If S1>S2, presence of moderate or severe CNS lesion in children at the age of 4 is predicted. If S1<S2, presence of light degree of severity, or absence of consequences of CNS lesion in children at the age of 4 is predicted.
Method for prediction of dysthyroidism / 2446401
Method involves woman's pre-delivery blood serum examination for nitrogen oxide and relaxin that is followed by calculation of the NO/relaxin relation. If the relation is 3.6 and less, dysthyroidism is predicted.
Method of predicting development of cerebral metastases in case of lung cancer in women / 2439579
In women in tissue of lung malignant tumour after radical surgery in pulmonectomy volume and in intact lung tissue, obtained from ablated from lung section of the same lung, level of progesterone is determined. If it reduces in tumour in 5 times and more relative the level of progesterone in intact lung tissue, development of cerebral lung cancer metastases in women within the term from 3 to 8 months is predicted.
Method of diagnosing androgenic deficiency / 2439578
In blood serum bioavailable testosterone fraction bound to albumin is determined. If its value is lower than 185.7 pg/ml, disease is diagnosed.
 Method of predicting survival potential of patients with malignant gliomas / 2439577
In patient's urine content of 6-sulfatoximelatonin is determined. If determined content of 6-sulfatoximelatonin after operation before complex treatment equals 292.7 nmol/ml survival to 2.3±0.5 months is predicted, if 22.4 nmol/ml is determined, survival for more than 12 months is predicted. If after chemical therapy determined content of 6-sulfatoximelatonin equals 268.2 nmll/ml, predicted survival time equals to 2.1±0.6 months, if content is 32.8 nmol/ml - more than 12 months. If after a month after treatment determined content of 6-sulfatoximelatonin equals 479.3 nmol/ml predicted is survival for 1.2±0.5 months, in case of 37.4 nmol/ml - survival for more than 12 months.
Method for prediction of cervical cancer metastases / 2436102
In 10-14 days following a surgical removal of a tumour in a patient, daily urine is analysed for sex hormones: oestradiol and pregnandiol. Then, they are related to each other. If the value exceeds 0.8, the onset of metastases or a recurrent disease for the following one and a half or two years is predicted. If the relation is less than 0.8, a metastases-free and recurrence-free period for more than 8-10 years is predicted.
Method of predicting state of fertility in women of reproductive age with uterus myoma / 2433411
At lutein phase of menstrual cycle concentrations of 2-hydroxyestrone 16α - hydroxyestrone in urine, concentration of progesterone in blood serum are determined. Then, canonical value is calculated by formula: K=4.23-0.04×A+0.0016×B-0.18×C, where A is concentration of progesterone in blood serum on 20-21 days of menstrual cycle (lutein phase) (nmol/l), B - concentration of 2-hydroxyestrone in urine (nmol/l), C - concentration of 16α - hydroxyestrone in urine (nmol/l). If K is higher than -0.175, infertility is predicted, if K is lower than -0.175 - safe fertility.
Method of predicting pregnancy in programme of extracorporal fertilisation and transfer of embryos in standard long protocol of superovulation stimulation / 2430379
Before programme of ECF and TE in standard long protocol of superovulation stimulation in patient analysis of hormonal status is performed - content of progesterone receptors in mononuclear fraction of peripheral blood cells is determined. Content of progesterone receptors in mononuclear fraction of peripheral blood cells is determined in the middle of luteal phase of patient's menstrual cycle, before administration of gonadotropin-releasing hormone agonist when carrying out treatment in accordance with standard long protocol of superovulation stimulation. If value is more than 700 progesterone receptors per cell, pregnancy as a result of programme of ECF and TE in standard long protocol of superovulation stimulation is predicted.
Method for prediction of developing mixed tick-borne encephalitis and borreliosis infection / 2456603
There are involved recording clinical and laboratory manifestations of a CNS injury during the first days of the disease that is followed by the calculation of total diagnostic coefficients related to the detected graduation levels of pathognomonic signs of the disease. Total (+)7 points and more is related to predicting the developing mixed tick-borne encephalitis and borreliosis infection. Total (-)8 points and less shows the developing potential monoinfection of tick-borne encephalitis. If deriving the intermediate values of total diagnostic coefficients when none of said limits is reached, the prognosis is uncertain.
Method for prediction of developing mixed tick-borne encephalitis and borreliosis infection / 2456603
There are involved recording clinical and laboratory manifestations of a CNS injury during the first days of the disease that is followed by the calculation of total diagnostic coefficients related to the detected graduation levels of pathognomonic signs of the disease. Total (+)7 points and more is related to predicting the developing mixed tick-borne encephalitis and borreliosis infection. Total (-)8 points and less shows the developing potential monoinfection of tick-borne encephalitis. If deriving the intermediate values of total diagnostic coefficients when none of said limits is reached, the prognosis is uncertain.
 Diagnostic technique in malignant solid tumours and remote metastases / 2456602
Blood serum (plasma) is examined by V-dehydration technique to study the produced structural macro-image. If observing in the central zone amorphous formations or grain crystals, as well as black mesh microcracks and black straight cracks extending into the intermediate zones, and/or if observing in the intermediate and/or border zones y-cracks, a malignant solid growth is diagnosed.
 Method for estimating clinical course of wound process accompanying diabetic foot syndrome / 2456601
On the second postoperative day, patient's blood serum is examined for low-density lipoproteins, malonic dialdehyde, glutathione peroxidase and glutathione reductase. Their integrals are calculated as the relation of the content of said lipid peroxidation products and antioxidant enzymes in the patients to an average content in healthy people. A prognostic coefficient is calculated by the relation of productions of the integrals of lipoproteins and malonic dialdehyde (P1×P2) to glutathione peroxidase and glutathione reductase (P3×P4) by formula
 Method for individual prediction of twenty-year risk of fatal cardiovascular event in middle-aged males / 2456600
It involves determining the blood lipid concentration, measuring an arterial pressure and rest heart rate in submaximal pre- and post-load test. Then a presented mathematical model is used to evaluate a risk of a fatal cardiovascular event over a twenty-year period.
 Method for prediction of developing postpartum osteopenic syndrome / 2456599
Bone isoenzyme of alkaline phosphatase and osteocalcin are evaluated on 22-24th weeks of pregnancy. If observing bone isoenzyme of alkaline phosphatase more than 6.0 Units/l and osteocalcin more than 9.0 ng/ml, developing postpartum osteopenic syndrome is predicted.
 Method for keeping viable blood cells for purposes of chemoluminescent analysis / 2456595
Method for keeping viable blood cells for purposes of chemoluminescence analysis involves blood sampling and preserving with the blood sampled in disposable plastic test tubes and Faglucide® used as a haemopreserving agent in the ratio 1:6; the prepared blood is kept at temperature 2 to 6°C.
Method of screening estimation of human functional body condition / 2455645
Invention describes a method of screening estimation of the humal functional body condition, involving the collection of exhaled moisture condensate (expirate), the preparation of a biosensor - luminescent lyophilised bacteria 'Ecolum', the addition of the expirate 0.5 cm3 to the biosensor 0.5 cm3, the 15-minute exposition, the measurement of luminescent emission of mixed bacterial suspension and condensate for 1000 sec, the recording of its maximum (Iop, imp/sec.), the comparison of said value with an analogue parameter Ik, imp/sec., derived by introducing distilled water in a bioluminometer tray instead of condensate in equal proportions, the determination of a coefficient K as the Iop/Ik relation which has a value of K=1 enables to state an optimal oxidative status; the value K>1 shows the prevailing pro-oxidative processes (a high level of formation of oxygen radicals, an insufficient level of protection against their damaging action), the value K<1 provides stating active antioxidant processes, sufficient reserves of protective mechanisms.
Method for prediction of developing recurrent angina following myocardial revascularisation / 2455644
Fresh morning urine is analysed for an albumin level (H). The values H≥0.15 g/l enable predicting developing recurrent angina following myocardial revascularisation.
Differential diagnostic technique for morphological forms of prostate cancer / 2455643
Invention describes a differential diagnostic technique for morphological forms of prostate cancer involving the examination of a blood serum sample, the processing of the derived data and the diagnosis of diseases wherein the examination is preceded by introducing chemical reagents in the blood serum sample, namely: phosphate buffer with pH 7.4-7.5, ferric sulphate (FeSO4) and hydrogen peroxide, light flux generated by conducting the chemical reaction; maximum luminous intensity (Imax) and light sum (S) characterising light emission for the first 30 seconds are recorded and measured; if observing the maximum luminous intensity (Imax) more than 3.2 mV and the light sum (S) more than 24.9 mV, prostate cancer is diagnosed as a tumour with infiltrating growth, while the value Imax being equal to or less than 3.2 mV and the value S equal to or less than 24.9 mV enable diagnosing prostate cancer without infiltrating growth.
 Method for assay of blood plasma density / 2244304
Invention relates to laboratory methods for blood analysis. Plasma is dropped in copper sulfate solution with density 1.023 g/cm3, not above, and time for drop falling on bottom of graduated cylinder with column height 243 mm is measured. The blood plasma density value is calculated by the formula:
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FIELD: medicine. SUBSTANCE: blood serum of a pregnant woman is examined for the oestradiol concentration by enzyme-linked immunosorbent assay. Observing the oestradiol concentrations exceeding normal values according to weeks of gestation in 1.4 times and more enables stating idiopathic nasal breathing irregularities accompanying a period of pregnancy. EFFECT: using the technique enables choosing an adequate therapeutic approach to the given pathology and avoiding to prescribe a number of unnecessary preparations undesired during pregnancy and causing a potential adverse effect on foetus development. 1 tbl, 3 ex
The invention relates to medicine, in particular to otorhinolaryngology. Idiopathic violation of nasal breathing occurs only during pregnancy, 20% of women in different periods of gestation (Ellegard E.K., N.G. Karlsson, 1999). For the first time this pathology was described by MacKenzie (MacKenzie J.N., 1898). For a long time, many researchers believed that idiopathic violation of nasal breathing is only a consequence of the effect of pregnancy on the available pathology of the nose and paranasal sinuses. Currently, however, idiopathic violation of nasal breathing is an independent nosological unit. Idiopathic violation of nasal breathing during pregnancy is a problem that needs currently, increasing attention not only because of the reduction in the quality of life of women, but also because of the impact of this disease on the reproductive health indicators and the negative impact on the offspring. The lack of adequate breathing leads to hypoxic disorders in the mother and the developing fetus. The difficulty of nasal breathing triggers the development of hypertension, pre-eclampsia in pregnant women, as well as slow fetal growth and lower scores on the Apgar scale for assessing the status of the child after birth (K..Franklin, P.A.Holmgren et al., 2000). A number of researchers traced the link between rhinitis pregnant, preeclampsia is her (N.Edwards, D.M.Blyton, T.Kirjavainen et al., 2000). This raises the problem idiopathic nasal breathing disorders in a broader framework. The pathogenesis of idiopathic nasal breathing disorders remains to be elucidated. Researchers propose several factors that cause symptoms and is typical for pregnant women, increased circulating blood volume, an increase in the concentration of progesterone that causes the relaxation of smooth muscles of blood vessels in the nasal cavity, the effects of estrogen, stimulating swelling of the mucous membrane through receptors found in the nasal cavities (Toppozada N., Michaels L, 1982). However, starting factor for the development of this pathology it is not revealed because of these changes in a woman's body is characteristic for all pregnant women, not only for patients with idiopathic violation of nasal breathing during pregnancy. Diagnosis of idiopathic nasal breathing disorders used by clinicians, based on the subjective complaints of the patient and rhinological seen by a doctor and is a diagnosis of exclusion allergic and inflammatory pathology of the nasal cavity. The specific method of diagnosis of this pathology it is not revealed. Some otorhinolaryngologists apply the method of rhinomanometry to assess the respiratory function of the nose, but this method is not the tsya objective, so as not to exclude other pathology, and only confirms the presence of nasal obstruction in a pregnant (Avenula, Nmeri, 2009). All this testifies to the relevance of the development method for the diagnosis of idiopathic nasal breathing disorders in pregnant women. The novelty of the proposal is that the regularities between nasal obstruction and changes in hormonal levels, namely the level of estradiol. The essential difference is that determines the concentration of estradiol and testimony, exceeding the norm by weeks of gestation 1.4 times or more, it is possible to judge about idiopathic violation of nasal breathing during pregnancy. We examined 35 pregnant women with idiopathic violation of nasal breathing associated with development of pregnancy in the absence of signs of respiratory infections and known allergic reasons. Women with concomitant diseases that affect the function of nasal breathing, from the study were excluded. Pregnant women were divided into subgroups depending on the period of gestation. We examined 11 women in the first trimester (7-8 week), and 15 women in the second (21-22 week) and 9 - III (35-36 weeks). The control group consisted of 25 healthy pregnant women without symptoms of nasal obstruction (8, 10, 7 patients in the I, II and III trimesters, respectively). We take what the R was determined by the level of estradiol in the serum by the method of enzyme-linked immunosorbent assay using a set of "DRG-diagnostics" on the analyzer Multiskan MS company "Labsystems (Finland). Estradiol was chosen for this study because of the potential effect on the mucous membrane through the estrogen receptors located in the nasal cavities. Women with idiopathic violation of nasal breathing disturbed nasal congestion, manifesting in various stages of pregnancy, in the absence of symptoms of respiratory infections, known allergic cause and mechanical barriers to adequate nasal breathing. However, to exclude a possible rhinosinusitis, also accompanied by nasal congestion, pregnant by standard methods (x-ray, computerized tomography (CT) was not possible due to the negative impact of these techniques on the fetus. When endoscopic examination of the nasal cavity of the studied contingent mucous membrane was pale pink, edematous, with signs of stagnation, sometimes there was scant serous-mucous discharge. In pregnant women with adequate nasal breathing mucous membrane of the nose was pink, nasal turbinates not increased. The nasal passages available and clean. When determining the level of estradiol in the serum following data were obtained in comparison with the control (see Figure 1). In the first trimester at 7-8 weeks in the study group the level of estradiol was 6.58+0.93 pmol/l, that is ,4 times higher compared to the control at the same gestation. In the second trimester at 21-22 weeks, the level of estradiol in the serum of pregnant women reached the level 41.53±3.68 pmol/l, that of 1.87 times higher than the data of the control group. In the third trimester at 35-36 weeks before the birth of the level of the investigated hormone was 136.28±10.04 pmol/l, which in turn exceeds the parameters of the control group at 1.37 times. The concentration of estradiol in the blood serum of the control group of pregnant women in I, II and III trimesters agreement with literature data of acceptable standards of this hormone by weeks of pregnancy (Gamalia, 1992). The calculation was performed by calculating the arithmetic mean values, variances, and allowable error. Calculation:
Δ=x-b, where A1, A2,...an - estradiol levels in the blood serum of women n - number of studied women in the group x - received a mean concentration of estradiol in the group Δ - deviation b - the minimum value of the concentration of estradiol in the group Control group I term:
Δ=3.67-2.7=0.97 Control group II trimester:
Δ=25.23-22.18=3.05 Control group III trimester:
Δ=105.46-99.68=5.78 The first trimester:
Δ=7.51-6.58=0.93 Second trimester:
Δ=at 45.21-41.53=3.68 Third trimester:
Δ=146.32-136.28=10.04 Clinical cases. Example 1: Patient M, 22 years. First pregnancy 21-22 weeks. Complaints of nasal obstruction, recurrent headaches with 7-8 weeks of pregnancy, always use vasoconstrictive drops. Pathology of pregnancy is not identified. When endoscopic examination of the nasal cavity mucosa pale pink, swollen, lower nasal turbinates increased with signs of stagnation, the nasal septum in the midline, the nasal passages available and clean. The level of estradiol in the blood 45,21 pmol/L. Conclusion: The patient idiopathic violation of nasal breathing. Recommended refusal drops, irrigation of the nasal cavity preparation "Dolphin". Nasal breathing has improved after 2 weeks of using the drug. Example 2: Patient B., 32 years. Second pregnancy 35-36 weeks. Complaints of nasal congestion, a feeling of lack of air, use vasoconstrictive drops, periodically applies the antibacterial drug "Bioparoks". Notes the appearance of nasal congestion with 7-8 weeks, with the first pregnancy from 11-12 weeks. Endoscopically in the nose: mucosa pink, pasty, lower nasal turbinates are enlarged, with stagnation. The nasal septum in the midline. The nasal passages available, scanty serous-mucous is e detachable. The level of estradiol in the blood 139,27 pmol/L. Conclusion: The patient idiopathic violation of nasal breathing. Recommended refusal drops, "Bioparox", short course drug "Nasonex" within 5-7 days, the irrigation of the nasal cavity "Dolphin". After treatment nasal congestion decreased concerned, only at night. Example 3: Palatka S., 27 years. First pregnancy 7-8 weeks. Complaints from ENT does not show. Nasal breathing is free. The mucosa of the nasal cavity pink wet. The nasal passages available and clean. The nasal septum in the midline. The lower nasal turbinates normal size. The level of estradiol in the blood 2.76 pmol/L. Conclusion: Healthy. Our research shows that levels of estradiol in serum significantly higher in pregnant women with idiopathic violation of nasal breathing compared with pregnant women without symptoms 2.4 times in the first trimester, 1,87 - II and 1,37 - in the third trimester. We observed a significant difference between the levels of estradiol in women with abnormal breathing in I and II trimesters of pregnancy and women in the control groups II and III terms that do not affect nasal congestion. It may be connected with a complex multifactorial mechanism of hormonal regulation of the physiology of the pregnant woman, preserving innediately the surface of the fruit. Thus, on the basis of our observations, the concentration of estradiol in the serum of women with idiopathic violation of nasal breathing during pregnancy can be a diagnostic criterion of this nosology. Accurate diagnosis of idiopathic nasal breathing disorders during pregnancy will allow you to pick a proper treatment of this pathology and to avoid unnecessary use of drugs (antibiotics, intranasal antibiotics, antihistamines and decongestants), which is undesirable during pregnancy and may have a negative impact on fetal development. Literature: 1. Agataeva IB, Kurlov AV Rhinitis pregnant. // Ross. rhinology, 2010, №3. - P.36-39. 2. Noula E.V., Black NM Features and clinical significance of objective testing of nasal breathing in pregnant women. // Russian otolaryngology, 2009, Appendix 2. - S-259. 3. Handbook of obstetrics and gynecology. // Edited Gamaliel. - M.: Medicine, 1992. - S. 4. Edwards N., Blyton D.M., Kirjavainen T., et al. Nasal continuous positiv eairway pressure reduces sleep-induced blood pressure increment sin preeclampsia. // Am J Respir Crit Care Med 2000, - Vol.162. - P.252-257. 5. Ellegard E.K., N.G. Karlsson Nasal congestion during pregnancy. // Clin. Otolaryngol., 1999. - Vol.24. - P.307-311. 6. Franklin K A., Holmgren P.A., Jfnsson F., etal. Snoring, pregnancy induced hypertension, and grow thretardation of the fetus. // Chest, 2000. - Vol.117. - P.41-137. 7. Topozada H., Michaels L., Toppozada M, El-Ghazzawie, Talaat M & S. Elwany The human nasal respiratory mucosa in pregnancy. An electron microscopic and histochemical study. // J. Laryngol. Otol., 1982, Vol.96, P.613-626. Method for the diagnosis of idiopathic nasal breathing disorders in pregnant through clinical research, characterized in that to determine the concentration of estradiol in serum and testimony, exceeding the norm by week pregnancy 1.4 times or more is judged idiopathic violation of nasal breathing.
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