Combination therapy of children suffering from celiac disease at health resort stage

FIELD: medicine.

SUBSTANCE: there is prescribed gluten-free diet with eliminating cereals and additional order of protein: meat 100.0 g, cottage cheese 100.0 g, or sour cream 100.0 g daily. Creon is dosed 10000 ME at mealtime within 2 weeks. It is combined with physiotherapy exercises (PTE) within 20-30 minutes. During afternoon, every second day circular douche is applied at pressure 1.5-2 atmospheres, water temperature 36-35°C for 3-4 minutes within therapeutic course 10-12 procedures. On another days, radon baths are taken at water temperature 36°C, dosed 0.75 kBq/l for 8-10 minutes within therapeutic course 8-10 procedures. Electrophoresis is applied daily with 50% Dimexide solution (±) for small intestine projection by transverse technique, current density 0.05 mA/cm2 within 12-15 minutes within therapeutic course 10-12. The BAPs VC-20, VC-22, E-36, Gi-4 are exposed to red and infrared light daily within 1.5-2 minutes per each point within therapeutic course 10-12 procedures.

EFFECT: reduced specific immunologic markers of autoimmune intestine inflammations and cytokine generation level, normalised immune response of an organism, normalised hormonal and exchange processes.

2 ex, 2 tbl

 

The invention relates to regenerative medicine, balneology, physiotherapy, Pediatrics, and can be used for rehabilitation of children with celiac disease in a sanatorium, health-care and rehabilitation facilities.

Known methods of rehabilitation of children with celiac disease, by assigning a gliadin free diet, enzyme preparations, preformed physical and natural factors[1, 2, 3, 4, 5, 6, 7, 8, 10,]. The disadvantage of these methods is the lack of efficiency due to fragmented using videofactory, lack of a comprehensive exposure to all stages of pathogenesis of the clinical course of the disease.

Closest to the present invention is a method of treatment of celiac disease, including diet therapy, drug treatments aimed at relief of abdominal pain, dyspeptic syndrome [1]. The disadvantage of this method is inefficient due to the lack of effects on the immune system, including autoimmune inflammatory process in the body.

The new technical problem of the invention is improving the efficiency of treatment by creating conditions for the normalization of clinical and immunological parameters.

To solve the problem in the method of complex treatment of children with Celia the iej, including gluten-free diet, enzyme therapy and physiobalneotherapy aimed at relief of abdominal pain, dyspeptic syndrome, correction of immune status, prescribed gluten-free diet with the exception of cereals and additional appointment protein: meat 100.0 g, curd 100.0 g or sour cream 100.0 g daily; drug therapy includes assigning CREON dose of 10000 ME during the meal within 2 weeks; fiziolechenie includes physical therapy (physical therapy), daily, 20-30 minutes, 21-24 days; circular shower pressure 1.5-2 atmosphere with the temperature of the water 36-35°C for 3-4 minutes, the procedure in the second half of the day, through the day, the course of 10-12 treatments; radon baths, water temperature 36°C 0,75 kBq/l, a day in the days free from the soul, for 8-10 minutes over a course of 8-10 treatments, and the procedure is carried in the second half of the day; electrophoresis of a 50% solution of Dimexidum (±) on the projection of the small intestine along the transverse method, the current density of 0.05 mA/cm2, current up to 5 mA, the exposure time is 12-15 minutes, at the rate of 10-12 daily, the procedure in 1-1,5 hours after a meal, also a local impact on prescription BAHT in the first half of the day using red light therapy and infrared range at BAT: VC-20, VC-22, F-36, Gi-4, symmetrically to the right and to the left, the method is stable, contact, vozdeystviyna one point 1.5-2 minutes, the total exposure time is 9-12 minutes, daily, 10-12 procedures.

The method consists in the application of the complex, including an optimized diet therapy, enzyme preparations, the effects of physiotherapeutic factors aimed at relief of abdominal pain syndrome, enteric, (balneotherapy), for normalization of immune status additionally conduct a local impact on prescription BAHT in the first half of the day using red light therapy and infrared range of the device, "Geske-Politsvet" at BAT: VC-20, VC-22, E-36 (symmetrically right and left), Gi-4 (symmetrically right and left), the method is stable, contact, the exposure time for one point 1.5-2 minutes, the total exposure time is 9-12 minutes, daily, 10-12 procedures.

The advantages of this method consist in a comprehensive approach to rehabilitation of children with celiac disease, aimed at the relief of abdominal pain, dyspeptic syndrome, correction of nutritional status. Of particular importance is the inclusion in the complex treatment of patients with phototherapy on BAT for the correction of impaired immunological parameters.

The method is as follows: children with celiac disease prescribed gluten-free diet, enzyme therapy and physiobalneotherapy aimed at relief of abdominal pain, the var is classical syndrome, correction of some indicators of immune status. Additionally appointed protein: meat 100,0, cheese 100,0 or sour cream 100,0 daily; drug therapy includes assigning CREON 10000 ME during the meal within 2 weeks; physical therapy (physical therapy), daily, 20-30 minutes, 21-24 days; circular shower, pressure of 1.5-2 atmospheres, the temperature of the water 36-35°C, for 3-4 minutes, the procedure is carried out in the second half of the day, every other day, at the rate of 10-12 procedures; appoint a radon bath, the water temperature is 36°C 0,75 kBq/l, every other day (days free soul), for 8-10 minutes over a course of 8-10 procedures (procedure will be released in the second half of the day); and electrophoresis of a 50% solution of Dimexidum (±) designate the projection of the small intestine by a transverse technique: forked anode placed on perdre-side surface of the anterior abdominal wall (anterior-axillary line on the right and left side, on the skin of the abdomen causing a 50% solution of Dimexidum 0.5-1 cm from the border of the anode in the amount of 1-2 ml, distributing on the front surface of the stomach with a glass rod to maintain a wet surface (pre-fixing electrodes). In the case of drying of the drug add Dimexidum when the electrodes. The cathode is disposed on the opposite side - the back so that the cross section of the electrodes formed an isosceles triangle. The size of the market anodes is determined by the length of the surface of the skin, which is applied to the Dimexidum, and their width does not exceed 2-3 cm, the area of the cathode is 25% of the area occupied by the drug. S1=S2=50 cm2(anode "+"), S3=70-100 cm2(cathode "-"). The current density of 0.05 mA/cm2, current up to 5 mA. The exposure time is 12-15 minutes, at the rate of 10-12 daily procedures.

Note: the procedure is released through 1-1,5 hours after a meal. Test for Dimexidum is held the day before the appointment procedure, for which: stick apply a 50% solution of Dimexidum on the inner surface of the forearm and see for 4-6 hours. The sample is considered positive when the appearance of redness, swelling, itching, rash at the application site Dimexidum. Pets slight redness of the skin at the site of impact. Additionally, conduct a local impact on prescription BAHT in the first half of the day using red light therapy and infrared range of the device, "Geske-Politsvet" at BAT: VC-20, VC-22, E-36 (symmetrically right and left), Gi-4 (symmetrically right and left), the method is stable, contact, the exposure time per point 1.5-2 minutes, the total exposure time is 9-12 minutes, daily, 10-12 procedures.

Rehabilitation of patients with celiac disease on the sanatorium stage was not given proper attention, not developed medical standards for treatment of children with this pathology in sanatoriums and preventoriums

Celiac disease is an autoimmune T-cell mediated enteropathy induced by gluten in genetically predisposed individuals. This disease is regarded as a chronic inflammation of the mucous membrane of the small intestine with the development of reversible atrophy of the mucosa and violation of the membrane processes of digestion and absorption of nutrients[4, 8, 11, 14, 15, 16]. Celiac disease is a multifactorial disease. It is proved that the manifestation of the disease occurs due to activation of both cellular and humoral immunity in genetically predisposed individuals, in response to the presence of gluten: prolamins and glutenin wheat, rye, barley, and (rarely) oats[2, 4, 5, 6, 19, 20].

Pathophysiological mechanisms underlying the damaging effects of gluten, closely associated with T-lymphocytes and deterministic genes of major histocompatibility complex (GCGS) [5, 14, 18, 19]. Association with celiac disease have been identified for many alleles and specificdate HLA. The genotype HLA - DQ2 detected in almost 95% of celiac patients, while other patients have HLA - DQ8. The main manifestation of the disease is a malabsorption syndrome, forming violations of all types of metabolism, as well as the polymorphism of clinical symptoms, making it difficult to diagnose, contributing to the development of many deficient state, the support is moved by the difficulties of adaptation of the child in society and eventually leads to disability [2, 3, 4, 5, 6, 16, 17]. Among the autoimmune disease celiac disease (CD) is still the least studied.

Delayed diagnosis a great contribution to the clinical picture of the disease contribute deficient state, which determine the polymorphism of the clinical symptoms [Yankina G.N., 2004; Gizybowska - Chlebowczyk U., H. Wos, Weicek S. et al., 2005; V. Ojetti, Nucera g, et al. 2005]. According to foreign researchers in the long unrecognized celiac disease increases the risk of tumors of the gastrointestinal tract and other localized and associated with celiac disease autoimmune diseases - diabetes of the 1st type, autoimmune thyroiditis and other[2, 5, 6, 10, 11, 12, 13].

The diagnosis of celiac disease is established on the basis of stage of diagnosis[2, 3, 4, 5, 6, 10, 11, 12, 13]. Methods of diagnosis of celiac disease consisted of 3 stages. At stage 1 are serological tests, including the determination antigliadin antibodies (Antigliadin antibody - AGA) class a and G, using kits "Hema" (Moscow). The 2nd stage involves performing endoscopic examination of duodenum and jejunum with taking a biopsy of the mucosa of the duodenum and/or jejunum with subsequent histological examination. The third stage involves the NLA - typing for specification of the diagnosis in case of negative results of the phase 1 or the violation for which sledovatelnot diagnosis and treatment (histological studies on the background of a gluten-free diet).

Currently, the only treatment for celiac disease is a strict lifelong gluten-free diet. Celiac disease should be excluded from the diet all glutaradehyde products and mixtures that contain wheat, rye, oat and barley flour. It should be noted that the diet of patients with celiac disease can be described as natural, full, fortified, without preservatives and fillers, food "market". In this situation, the family focuses on the use of natural food products rather than "by-products". A special place is occupied by enzyme therapy. On the background of a strict gluten-free diet in children with poor nutritional status appointed enzyme therapy aimed at correcting enteric disorders in celiac disease: CREON in age dosage 3 times a day for 2 weeks or more if necessary (RU Russia P # 015581/01, manufacturer Solvay pharmaceuticals GmbH, Hans-bockler-Allee 20 30173 Hannover, Germany) [4].

In the proposed method, the parameters of influence factors rehabilitation sanatorium stage selected taking into account the main pathogenetic mechanisms of the disease development, promoting as relief of clinical symptoms, correction of some indicators of immune status. Hydrotherapy is shown when RA is personal diseases and have a tonic, toning, training effect on the body. With this purpose appoint circular shower. Pressure of 1.5-2 atmospheres selected taking into account the child's age;water temperature 36-35°C with the aim of zaklepanja of the body and stimulation of nonspecific resistance; a time for 3-4 minutes selected with consideration of the peculiarities of thermoregulation in children; the procedure is carried out in the second half of the day, so the child can relax during afternoon NAP after the procedure, arrangement circular shower every other day due to the inappropriateness of assigning bath and shower in one day (procedures General effects on the body); in the course of 10-12 selected based on the duration of treatment of patients in the sanatorium. The purpose of radon baths based on their General anti-inflammatory action, activating the system, nonspecific resistance, giposensibiliziruyuschey effect. In clinical studies it was found that under the influence of radon baths in children and adolescents with autoimmune diseases there were positive changes in the clinical picture, decreased immunological tension, hyposensitizing effect by reducing the amount of circulating immune complexes in the peripheral blood, normalization of the number of lymphocytes, a decrease in the number of antibodies. Among such diseases include celiac disease. Baths in C which show the method prescribed through the day, to avoid overloading adaptive systems of children. With the same purpose, the selected concentration of radon baths, duration of procedure, the time of receipt of the baths in the afternoon. The number of procedures 8-10, in the present method is selected taking into account the duration of the treatment of the child in sanatorium-and-Spa institution (21-24 days).

The obvious need for the application of non-invasive techniques of correction of secondary immunodeficiency in children with celiac disease, such as exposure to red-infrared radiation on biologically active points (BAP) [8, 15]. Light therapy is a natural treatment. Proved the identity of the biological effect of laser and non-coherent radiation at the same wavelength and intensity) has created a series of devices without laser radiation, which as sources of optical radiation of red, infrared LEDs are used as "GESKE", "GESKE-POLITSVET" [8]. Red (620-780 nm) - has a stimulating effect on humans, accelerates blood flow, metabolism, increases immunity. Light therapy is prescribed to correct the above violations red (wavelength 660-675 nm, the radiation power density of 1 mW/cm2) and infrared range (wavelength 840-950 nm, the radiation power density of 2.7 mW/cm) at BAT: VC-20, VC-22,E-36 (symmetrically right and left), Gi-4 (symmetrically right and left), according to the conventional formulation [8], the exposure time per point 1.5-2 minutes, the total exposure time is 9-12 minutes, daily, 10-12 procedures. Treatment 21-24 days. Therapeutic effect of phototherapy is associated with biostimulating effect on the most important activity of tissue enzymes, biosynthesis of proteins, DNA, RNA, makroergov, resulting in a change metabolism in tissues. The activation of transport processes due to the increased permeability of the cytoplasmic membrane increases the redox potential and oxygenation in the tissues. And because of phototherapy exposure exposed to the blood and lymph, then almost any local irradiation may be the nature of the exposure. It was established that DNA molecules, for example, a typical maximum spectral sensitivity in the range 660-675 nm (red emission) and 840-950 nm (infrared radiation). This explains the greatest efficiency therapeutic therapeutic radiation that range. The choice of the density of the radiation power of 1 mW/cm2provided the most gentle effect on the reflex points of the body. The exposure time per point 1.5-2 minutes were intended to provide a stimulating impact on the BAHT, which is responsible for the immunity in the body. Appointment procedures daily is UPE and the rate of 10-12 impacts caused by the reaction of the "expectations" of the body and a more active response to the healing factor.

Important for reduction of chronic inflammation in the small intestine and improve reparative processes is the search for new physiotherapy therapies for local use. In this connection it is noteworthy galvanization, electrophoresis of drugs, which in addition to anti-inflammatory actions, contribute to the normalization of contractile and enzymatic activity of the digestive system [8, 15].

In connection with the above becomes relevant application in the form of electrophoresis of drugs with General and local anti-inflammatory activity, local anesthetic, antiseptic and anti-fibrinolytic action. These properties characterise the Dimexidum, fast and good penetration through biological membranes, including the skin and mucous membranes, increasing their permeability to other medicines. Dimexide changes the sensitivity of microflora that are resistant to antibiotics. In most cases it is used in combination with other medicinal substances (pre-dissolved in it or applying it on the skin for better and deeper penetration in tissue.

Using the proposed method of treatment in children and adolescents with celiac disease contributes to relief of abdominal pain, dyspeptic syndrome, str is ccheney nutritional status, correction of some parameters of the immune system.

Thus, a comprehensive approach to treatment will eventually lead to improving the quality of life of a child with celiac disease.

For a better understanding of the essence of the method proposed specific examples of its implementation.

Example 1

Patient M., aged 14, was in the children's Department from March 22 to April 15, 2006 with a diagnosis of Celiac disease, a typical phase subcompensation.

From the anamnesis: it is under the supervision of a gastroenterologist since 1999, when I first complained about abdominal pain, recurrent vomiting after eating the cereal, dairy products, constipation, stool with oily gloss, born with a bad gain in body weight. From the family anamnesis it is known that the girl's parents suffer from chronic colitis, gastroduodenitis, mom perenosa dairy products. The patient's body weight corresponded to 50, and the growth of the 25th percentiles. The body mass index was 18.7, which corresponds to the class I of body mass index. Sexual development is age-appropriate. Focuses on the examination and treatment at the children's ward 1 city children's hospital. At admission there were complaints of recurrent abdominal pain, mainly associated with the violation of gluten-free diet (bread, biscuits), reduced appetite, discomfort in the epigastrium, fatigue, tendency to constipation (stool 1 is AZ in 2-3 days decorated with bold gloss), dry skin.

At the examination before treatment pale skin on the buttocks, thighs, stomach, dryness, flaking.

Immunological analysis of blood before treatment: leukocytes is 6.4×109, lymphocytes - 39% (1.68 g/l, leucocytes - 61% (4,16 g/l), b-lymphocytes - 17%, T-lymphocytes - 27%, T-helpers - 14%, T-suppressors - 13%, antibodies to gluten IgA class is 3.5 units/ml (normal up to 40 units/ml), IgG - 141,7 IU/ml (normal up to 35 u/ml). IL-1β - 198,67 PG/ml, TNF-α - 368,84 PG/ml, IL-4 - 125,46 PG/ml, IL-6 - 104,58 PG/ml.

A biopsy of the small intestine in the studied fragment of the jejunal villi large, tortuous, with signs of atrophy. The stroma of the villi moderately swollen with scarce infiltration by eosinophils.

Hormones blood corresponded to the reference values: TSH=2,54 mIU/ml, T3=1,4.

Treatment is appointed in accordance with the claimed method.

Day 1:

- Diet gluten-free (with the exception of cereals). Additionally appointed protein: meat 100.0 g, cheese 100.0 g or sour cream 100.0 g daily.

- Physical therapy, 30 minutes, daily, at the rate of 24 treatments.

- Light (red and infrared) through the BAT [16]: VC-20, VC-22, E-36 (steam room), Gi-4 (steam room), the method is stable, contact, the exposure time per point 2 minutes total exposure time of 12 minutes. In the course of 12 treatments daily in the first half of the day.

- Circular shower, pressure water jet 2 and the layer of atmosphere, water temperature 35°C, 4 minutes, in the course of 12 treatments every other day (alternating days with radon baths) in the second half of the day.

Electrophoresis solution Dimexidum 50% on the projection of the small intestine by a transverse technique. The location of the electrodes: a forked electrode - the anode is located on the front-side surface of the anterior abdominal wall in the anterior-axillary line on the right and left, the dimensions of the electrodes (anodes) are determined by the length of the surface of the skin, which is applied to the Dimexidum, and their width does not exceed 2-3 cm (S1=S2=50 cm2), the area of the cathode is 25% of the area occupied by the drug (S3=70-100 cm2). The cathode is located opposite on the back so that the cross section of the electrodes formed an isosceles triangle. On the skin of the abdomen in the projection of 0.5-1 cm from the border of the bifurcated electrode (anode) with a glass rod to apply the solution Dimexidum 50% - 1,0-2,0 ml of a current Density of 0.05 mA/cm2, current up to 5 mA. The exposure time is 15 minutes, in the course of 10 daily procedures. The procedure is performed through 1-1,5 hours after a meal.

Note: the test Dimexidum is held the day before the appointment procedure and is carried out as follows: a solution of Dimexidum 50% is applied with a wand on the inner surface of the forearm and the skin reaction is observed for 4-6 hours. The sample is considered Polo is sustained fashion with the appearance of redness, swelling, itching, rash at the application site Dimexidum. Pets slight redness of the skin at the site of impact.

- Medication: CREON 10000 IU 3 times a day during meals for 2 weeks.

Day 2:

- Diet gluten-free (with the exception of cereals). Additionally appointed protein: meat 100,0, cheese 100,0 or sour cream 100,0 daily.

- Physical therapy, 30 minutes, daily, at the rate of 24 treatments.

- Light (red and infrared) through the BAT [16]: VC-20, VC-22, E-36 (steam room), Gi-4 (steam room), the method is stable, contact, the exposure time per point 2 minutes total exposure time of 12 minutes. In the course of 12 treatments daily in the first half of the day.

- Radon baths (artificial) 0,75 kBq/l, water temperature 35°C, with a duration of 10 minutes, in the course of 10 treatments every other day (alternating days with a circular shower) in the second half of the day.

Electrophoresis solution Dimexidum 50% on the projection of the small intestine by a transverse technique. The location of the electrodes: a forked electrode - the anode is located on the front-side surface of the anterior abdominal wall in the anterior-axillary line on the right and left, the dimensions of the electrodes (anodes) are determined by the length of the surface of the skin, which is applied to the Dimexidum, and their width does not exceed 2-3 cm (S1=S2=50 cm2), the area of the cathode is 25% of the horses, consumption of medicinal substance (S3=70-100 cm2). The cathode is located opposite on the back so that the cross section of the electrodes formed an isosceles triangle. On the skin of the abdomen in the projection of 0.5-1 cm from the border of the bifurcated electrode (anode) with a glass rod to apply the solution Dimexidum 50% to 2.0 ml of the current Density of 0.05 mA/cm2, current up to 5 mA. The exposure time is 15 minutes, in the course of 12 daily procedures. The procedure is performed through 1-1,5 hours after a meal.

Note: the test Dimexidum is held the day before the appointment procedure and is carried out as follows: a solution of Dimexidum 50% is applied with a wand on the inner surface of the forearm and the skin reaction is observed for 4-6 hours. The sample is considered positive when the appearance of redness, swelling, itching, rash at the application site Dimexidum. Pets slight redness of the skin at the site of impact.

Medical therapy: CREON 10000 IU 3 times a day during meals, for 2 weeks.

The duration of treatment was 24 days. Health by the end of treatment had not suffered abdominal pain syndrome regressed gradually was noted after treatment, dry skin became less pronounced, the chair became a daily or every other day, decorated, non-greasy. Volume and structure of the thyroid gland after treatment has not changed. The weight gain part of the La 1.2 kg after treatment. Immunological analysis of blood after treatment: leukocytes of 6.1×109, lymphocytes - 30% (1.56 g/l, leucocytes - 70% (4,48 g/l), b-lymphocytes - 15%, T-lymphocytes - 28%, T-helpers - 12%, T-suppressors - 16%, antibodies to gluten IgA class is 3.5 units/ml (normal up to 40 units/ml), IgG - 47,7 IU/ml (normal up to 35 u/ml). IL-1β - 124,54 PG/ml, TNF-α - 278,18 PG/ml, IL-4 - 146,61 PG/ml, IL-6 - 101,65 PG/ml.

Example 2

Patient E., age 8, was in the children's Department from 1 February to 24 February 2007 with a diagnosis of Celiac disease, atypical, phase subcompensation.

From the anamnesis: it is under the supervision of a gastroenterologist since 2001, when I first complained about lag in physical development, abdominal pain, constipation, sometimes diarrhea with oily Shine, iron deficiency anemia with 1 year. From the family anamnesis it is known that the girl's mother suffers from intolerance to cow's milk and chronic pancreatitis. The patient's body weight corresponded to 50, and the growth of the 25th percentiles. The body mass index was 16.8, which corresponds to the class I of body mass index. Aimed at the treatment research Institute of medical genetics, the children's Department, where she was diagnosed with celiac disease. Child over 6 years is stogi gluten-free diet.

During the inspection to ensure the skin is pale, dry, brittle nails and hair. Asthenic physique. Belly increased in volume (swollen), palpation painless is a, rumbling along the small and large intestines, liver 2 cm stands from under the costal arch on srednechrochnoy line, painless at the point Kera.

Immunological analysis of blood before treatment: leukocytes of 56.4×109, lymphocytes - 41% (1,74 g/l, leucocytes - 59% (of 3.78 g/l), b-lymphocytes - 13%, T-lymphocytes - 28%, T-helpers - 10%, T-suppressors - 19%, antibodies to gluten IgA class of 14.5 units/ml (normal up to 40 units/ml), IgG - 41,7 IU/ml (normal up to 35 u/ml). IL-1β - 173,65 PG/ml, TNF-α - 321,80 PG/ml, IL-4 - at 83.54 PG/ml, IL-6 - schedule rate is now 99.14 PG/ml.

A biopsy of the small intestine in the studied fragment of the jejunal villi large, tortuous, with no signs of atrophy. The stroma of the villi moderately swollen with scarce infiltration by lymphocytes.

Hormones blood corresponded to the reference values: TSH=1,87 mIU/ml, T3=1,5.

Treatment is appointed in accordance with the claimed method.

Day 1:

- Diet gluten-free (with the exception of cereals). Additionally appointed protein: meat 100.0 g, cheese 100.0 g, or sour cream 100.0 g daily.

- Physical therapy, for 20 minutes daily, at the rate of 21 procedure.

- Light (red and infrared) through the BAT [16]: VC-20, VC-22, E-36 (steam room), Gi-4 (steam room), the method is stable, contact, the exposure time per point 1.5 minutes, the total exposure time is 9 minutes. In the course of 10 procedures carried out daily in the first half of the day.

- Circular shower, pressure structure is water 1.5 atmosphere, the water temperature is 36°C for 3 minutes, in the course of 10 treatments every other day (alternating days with radon baths) in the second half of the day.

Electrophoresis solution Dimexidum 50% on the projection of the small intestine by a transverse technique. The location of the electrodes: a forked electrode - the anode is located on the front-side surface of the anterior abdominal wall in the anterior-axillary line on the right and left, the dimensions of the electrodes (anodes) are determined by the length of the surface of the skin, which is applied to the Dimexidum, and their width does not exceed 2-3 cm (S1=S2=50 cm2), the area of the cathode is 25% of the area occupied by the drug (S3=70-100 cm2). The cathode is located opposite on the back so that the cross section of the electrodes formed an isosceles triangle. On the skin of the abdomen in the projection of 0.5-1 cm from the border of the bifurcated electrode (anode) with a glass rod to apply the solution Dimexidum 50% to 1.0 ml of the current Density of 0.05 mA/cm2, current up to 5 mA. The exposure time of 12 minutes, at the rate of 10 daily procedures. The procedure is performed through 1-1,5 hours after a meal.

Note: the test Dimexidum is held the day before the appointment procedure and is carried out as follows: a solution of Dimexidum 50% is applied with a wand on the inner surface of the forearm and the skin reaction is observed for 4-6 hours. The sample is put is entrusted with the appearance of redness, swelling, itching, rash at the application site Dimexidum. Pets slight redness of the skin at the site of impact.

- Medication: CREON 10000 IU 3 times a day during meals for 2 weeks.

Day 2:

- Diet gluten-free (with the exception of cereals). Additionally appointed protein: meat 100.0 g, cheese 100.0 g, or sour cream 100.0 g daily.

- Physical therapy, for 20 minutes daily, at the rate of 21 procedure.

- Light (red and infrared) through the BAT [16]: VC-20, VC-22, E-36 (steam room), Gi-4 (steam room), the method is stable, contact, the exposure time per point 1.5 minutes, the total exposure time is 9 minutes. In the course of 10 procedures carried out daily in the first half of the day.

- Radon baths (artificial) 0,75 kBq/l, with a water temperature of 36°C, with a duration of 10 minutes over a course of 8 treatments every other day (alternating days with a circular shower) in the second half of the day.

Electrophoresis solution Dimexidum - 50% on the projection of the small intestine by a transverse technique. The location of the electrodes: a forked electrode - the anode is located on the front-side surface of the anterior abdominal wall in the anterior-axillary line on the right and left, the dimensions of the electrodes (anodes) are determined by the length of the surface of the skin, which is applied to the Dimexidum, and their width does not exceed 2-3 cm (S1=S2=50 cm2), the area of the cathode sostavljaet% of the area, consumption of medicinal substance (S3=70-100 cm2). The cathode is located opposite on the back so that the cross section of the electrodes formed an isosceles triangle. On the skin of the abdomen in the projection of 0.5-1 cm from the border of the bifurcated electrode (anode) with a glass rod to apply the solution Dimexidum 50% to 1.0 ml of the current Density of 0.05 mA/cm2, current up to 5 mA. The exposure time of 12 minutes, at the rate of 10 daily procedures. The procedure is performed through 1-1,5 hours after a meal.

Note: the test Dimexidum is held the day before the appointment procedure and is carried out as follows: a solution of Dimexidum 50% is applied with a wand on the inner surface of the forearm and the skin reaction is observed for 4-6 hours. The sample is considered positive when the appearance of redness, swelling, itching, rash at the application site Dimexidum. Pets slight redness of the skin at the site of impact.

Medical therapy: CREON 10000 IU 2 times a day during meals, for 2 weeks.

The duration of treatment was 21 days. Health by the end of treatment had not suffered abdominal pain syndrome is not disturbed, dry skin decreased stool daily, decorated, non-greasy, occasionally liquefaction chair until pasty. The weight gain of 0.8 kg after treatment. Immunological analysis of blood after treatment: Le is cocity - the 5.7×109, lymphocytes - 33% (1.50 g/l, leucocytes - 67% (4,08 g/l), b-lymphocytes - 13%, T-lymphocytes - 20%, T-helpers - 12%, T-suppressors - 19%, antibodies to gluten IgA class - 11,0 units/ml (normal up to 40 units/ml), IgG - 34,6 IU/ml (normal up to 35 u/ml). IL-1β - 95,48 PG/ml, TNF-α - 252,47 PG/ml, IL-4 - 83,21 PG/ml, IL-6 - 81.51 seen PG/ml.

The execution mode of the proposed method is based on clinical observations.

The criteria for assessing the effectiveness of treatment are the following indicators:

1) reducing the number of complaints and clinical symptoms; celiac disease: mild abdominal pain, enteric syndrome;

2) increase of body weight during the treatment period;

3) improvement of some immunological parameters of blood.

Under observation in the clinic FGI "Tomsk scientific research Institute of balneology and physiotherapy University" were 27 children with various forms of celiac disease (typical and atypical). The average age of patients was 8.6±0,7 years. Boys surveyed were 16 (59.2 per cent) people, girls 11 people (40,8%). The comparison group consisted of 20 healthy children of the same age and sex who do not have chronic diseases and acute in the last 2-3 months prior to the survey. Stunting and underweight was observed in 12 (75%) of people with typical shape and 7 (63,6%) with atypical.

The typical clinical course of the disease was noted in 16 children (59,2%), 11 (40.8 per cent) patentovedenie disease was characterized as atypical. Typical symptoms were abdominal pain in 11 children (68,8%), steatorrhea in 8 patients (50%), diarrhea in 7 (43.7 per cent), nausea in 8 patients (50%). Children with atypical form of celiac disease was characterized by the absence of intestinal symptoms, (however, due to the presence of the conjugate of a pathology gastrointestinal tract (chronic gastroduodenitis, parasitosis) 7 (63,6%) patients had abdominal pain syndrome. Extraintestinal manifestations such as anemia, met in 5 patients (45.4 per cent), alopecia in 2 cases (18.2%)and autoimmune thyroiditis in 8 children (72,7%), atopic dermatitis in 5 men (45.4%), bronchial asthma in 3 cases (27,2%).

Immunological examination held on 27 children with celiac disease. Level antigliadin antibodies (AGA) class a and G were determined using kits "Hema" (Moscow). In children with typical form of the disease the level of the AGA was raised in 15 (89%), 1 child (11%) level of AGA was normal. In a typical form of celiac disease level AGA AND was raised in 6 (37.5%) of the people (55,71±8,78, u/ml), AGA G was increased in 15 (93,7%) children (177,33±8,5, IU/ml). This increased level of antibodies both classes registered in 6 (37.5%) of the people - AND YEAH 114,09±17,2, IU/ml; AGA G 240,17±17,21, IU/ml With an atypical form of the disease the level of the AGA was increased in 8 (72.7%) patients AND YEAH 35,54±9,4, IU/ml; AGA G - 142,99±remaining 9.08, IU/ml); the simultaneous increase of the level and the antibodies of both classes was noted in 5 (45.4%) of the people - YEAH AND 74,67±volume of 34.12, IU/ml; AGA G - 124,54±12,34, IU/ml; isolated increase AGA G in 6 (54.5 per cent) of children 157,7±are 11.62, IU/ml

The histological pattern corresponding to the 1 stage of the disease (.Marsh, 1995), was detected in 18 (49%) children, 2nd stage 2 (5%), stage 9 (24%) patients, and 36 stage 8 (22%) children. More pronounced effects hyperelementary atrophy was observed at typical celiac 30% vs. 16% for atypical.

After treatment with typical forms of the disease abdominal symptoms such as pain was gone in 10 children (90%), steatorrhea, 6 patients (75%), diarrhea - all 7 (100%), nausea in 6 (75%) children. When atypical forms after therapy anemia persisted in 2 patients (18.2%)and atopic dermatitis had a tendency to regress skin symptoms in 4 people (80%). During the time spent in the Department of children gaining weight from 200,0 to 1200 grams.

All patients were informed about the necessity of a strict GFD, the presence of the hidden gluten in various products. When monitoring children 6 months in 18 out of 27 people (66,6%) of children registered increase isoretonin indicators on average 0.67±0,12, (kg) appetite returned to normal in 14 (51,8%) children, chair 21 (77,7%), increase growth in 9 people (33,3%) for 6 months was 2.2±0,10, (cm).

Celiac disease occurs lymphocytosis. On the background of sanatorium-resort treatment number is impositon (absolute and relative) was significantly decreased (table 1). This fact may indicate a reduction in the activity of the autoimmune process against the background of complex treatment.

Under the supervision and compliance of gliadin free diet observed decrease and normalization of the number antigliadin antibodies, which testifies to the development of autoimmune inflammation of the mucous membrane of the small intestine. Of the 27 children constantly dieted in the follow-up period (>6 months) 22 (81.5%of) people. Against this background, in 19 (86,3%) children were normalized level antigliadin antibodies (mean YEAH BUT 10,1 (U/ml), AGA 27,2 G (U/ml).

Immune responses are regulated by endogenous mediators - cytokines produced by immune cells. Cytokines affect the proliferation of cells of the mucous membranes, local and systemic immune response.

The results of the evaluation of the level of cytokines (IL-1β, IL-6, TNF-α, IL-4) in serum are presented in table 2.

In 24 patients with celiac disease have conducted cytokine profile of blood. Interleukins IL-1β, TNF-α, IL-4, IL-6 was determined by ELISA using a standard set by "Vector-best". Comparative analysis was performed between children with celiac disease before and after treatment, comparing with the group of healthy patients. The division into typical or atypical forms are not conducted.

When evaluating the obtained results revealed that IL-1β had high values at admission in children with celiac disease, compared with healthy (table 2). Due to the treatment with this cytokine has not changed. However, the level of IL-1β in the group with normal levels of IL-1β was normalized during treatment.

On the background of complex therapy showed a significant decrease of proinflammatory indicators of IL-1β, IL-6 and TNF-α in the range of normal values. Two patients with severe resistant for celiac disease had high levels of all studied cytokines, which in the course of treatment was not changed.

In patients with celiac disease with a high content of IL-4, which is a natural inhibitor of Pro-inflammatory cytokines - IL-1β, IL-6, TNF-α plays a positive role, aimed at limiting the inflammatory and destructive processes in the mucous membrane of the small intestine. On the other hand a high concentration of IL-4 in patients with celiac disease supports the production of antibodies to gliadin, tissue transglutaminase. The assessment of the content of cytokines with functionally different properties is a qualitative indicator of the adequacy of the immune response, helping to analyze the effectiveness of treatment of patients with celiac disease.

Thus, the developed complex rehabilitation helps reverse the dynamics of clinical symptoms of the disease, improve nutritional status, reduce specific immunological markers of autoimmune FOTS the population in the intestine and the level of production of cytokines, the normalization of the immune response. The criteria for assessing the effectiveness of treatment are the following indicators: reduction in the number of complaints and clinical symptoms; celiac disease: mild abdominal pain, enteric syndrome; the increase in body weight during the treatment period; the improvement of some immunological parameters of blood of the patients.

Under observation in the clinic FGI "Tomsk scientific research Institute of balneology and physiotherapy University" were 27 children with various forms of celiac disease (typical and atypical). The average age of patients was 8.6±0,7 years. Boys surveyed were 16 (59.2 per cent) people, girls 11 people (40,8%). The comparison group consisted of 20 healthy children of the same age and sex who do not have chronic diseases and acute in the last 2-3 months prior to the survey. Stunting and underweight was observed in 12 (75%) of people with typical shape and 7 (63,6%) with atypical.

The typical clinical course of the disease was noted in 16 children (59,2%), 11 (40,8%) patients the disease was characterized as atypical. Typical symptoms were abdominal pain in 11 children (68,8%), steatorrhea in 8 patients (50%), diarrhea in 7 (43.7 per cent), nausea in 8 patients (50%). Children with atypical form of celiac disease was characterized by the absence of intestinal symptoms, (however, due to the presence of a conjugate is pathology of the gastrointestinal tract (chronic gastroduodenitis, the parasitosis) 7 (63,6%) patients had abdominal pain syndrome. Extraintestinal manifestations such as anemia, met in 5 patients (45.4 per cent), alopecia in 2 cases (18.2%)and autoimmune thyroiditis in 8 children (72,7%), atopic dermatitis in 5 men (45.4%), bronchial asthma in 3 cases (27,2%).

Immunological examination held on 27 children with celiac disease. Level antigliadin antibodies (AGA) class a and G were determined using kits "Hema" (Moscow). In children with typical form of the disease the level of the AGA was raised in 15 (89%), 1 child (11%) level of AGA was normal. In a typical form of celiac disease level AGA AND was raised in 6 (37.5%) of the people (55,71±8,78, u/ml), AGA G was increased in 15 (93,7%) children (177,33±8,5, IU/ml). This increased level of antibodies both classes registered in 6 (37.5%) of the people - AND YEAH 114,09±17,2, IU/ml; AGA G 240,17±17,21, IU/ml With an atypical form of the disease the level of the AGA was increased in 8 (72.7%) patients AND YEAH 35,54±9,4, IU/ml; AGA G - 142,99±remaining 9.08, IU/ml); the simultaneous increase in the level of antibodies of both classes was noted in 5 (45.4%) of the people - AND YEAH 74,67±volume of 34.12, IU/ml; G YEAH - 124,54±12,34, IU/ml; isolated increase AGA G in 6 (54.5 per cent) of children 157,7±are 11.62, IU/ml

The histological pattern corresponding to the 1 stage of the disease (.Marsh, 1995), was detected in 18 (49%) children, 2nd stage 2 (5%) people. For stage 9 (24%) patients, and 36 stage 8 (22%) on the TEI. More pronounced effects hyperelementary atrophy was observed at typical celiac 30% vs. 16% for atypical.

After treatment with typical forms of the disease abdominal symptoms such as pain was gone in 10 children (90%), steatorrhea, 6 patients (75%), diarrhea - all 7 (100%), nausea in 6 (75%) children. When atypical forms after therapy anemia persisted in 2 patients (18.2%)and atopic dermatitis had a tendency to regress skin symptoms in 4 people (80%). During the time spent in the Department of children gaining weight from 200,0 to 1200 grams.

All patients were informed about the necessity of a strict GFD, the presence of the hidden gluten in various products. When monitoring children 6 months in 18 out of 27 people (66,6%) of children registered increase the weight and height values on average 0.67±0,12, (kg) appetite returned to normal in 14 (51,8%) children, chair 21 (77,7%), increase growth in 9 people (33,3%) for 6 months was 2.2±0,10, (cm). Celiac disease occurs lymphocytosis. On the background of sanatorium-resort treatment, the number of lymphocytes (absolute and relative) was significantly decreased (table 1). This fact may indicate a reduction in the activity of the autoimmune process against the background of complex treatment.

Under the supervision and compliance of gliadin free diet observed decrease and normal is the nation's number antigliadin antibodies that testifies to the development of autoimmune inflammation of the mucous membrane of the small intestine. Of the 27 children constantly dieted in the follow-up period (>6 months) 22 (81.5%of) people. Against this background, in 19 (86,3%) children were normalized level antigliadin antibodies (mean YEAH BUT 10,1 (U/ml), AGA 27,2 G (U/ml).

Immune responses are regulated by endogenous mediators - cytokines produced by immune cells. Cytokines affect the proliferation of cells of the mucous membranes, local and systemic immune response.

The results of the evaluation of the level of cytokines (IL-1β, IL-6, TNF-α, IL-4) in serum are presented in table 2.

In 24 patients with celiac disease have conducted cytokine profile of blood. Interleukins IL-1β, TNF-α, IL-4, IL-6 was determined by ELISA using a standard set by "Vector-best". Comparative analysis was performed between children with celiac disease before and after treatment, comparing with the group of healthy patients. The division into typical or atypical forms did not. When evaluating the obtained results revealed that IL-1β had high values at admission in children with celiac disease, compared with healthy (table 2). Due to the treatment with this cytokine has not changed. However, the level of IL-1β in the group with normal levels of IL-1β was normalized during treatment.

On the background have the th complex therapy showed a significant decrease of proinflammatory indicators of IL-1β, IL-6 and TNF-α in the range of normal values. Two patients with severe resistant for celiac disease had high levels of all studied cytokines, which in the course of treatment was not changed.

In patients with celiac disease with a high content of IL-4, which is a natural inhibitor of Pro-inflammatory cytokines - IL-1β, IL-6, TNF-α plays a positive role, aimed at limiting the inflammatory and destructive processes in the mucous membrane of the small intestine. On the other hand a high concentration of IL-4 in patients with celiac disease supports the production of antibodies to gliadin, tissue transglutaminase. The assessment of the content of cytokines with functionally different properties is a qualitative indicator of the adequacy of the immune response, helping to analyze the effectiveness of treatment of patients with celiac disease.

Thus, the developed complex rehabilitation helps reverse the dynamics of clinical symptoms of the disease, improve nutritional status, reduce specific immunological markers of autoimmune inflammation in the intestine and the level of production of cytokines, the normalization of the immune response, reduction, weight, maintaining functional status and reducing the size of an enlarged thyroid, correction of vegetative status, normalize hormonal and metabolic processes, improve the structure of physical performance, motivation for treatment, reducing the emotional and personality disorders.

Sources of information

1. Avdeev VG Questions of pathogenesis, diagnosis and treatment of celiac disease // Clinical pharmacology and therapeutics. - 2004, 13 (1). - P.34-38.

2. Arwin LI, Kapeller L.L., Isakov V.A. Belmer SV a Draft Protocol for the diagnosis and treatment of celiac disease in children // child nutrition. - 2004. - Vol.2, No. 1. - P.87-103.

3. Belmer SV, Gasilina T., Kovalenko A.A. Celiac disease: state of the problem // the physician. 2003. - N-6. Pp.69-71.

4. Valevich M.N., Gaskov A.P., Beisebaev E.A., Bugembaeva PPM three-tiered approach to the assessment of chronic diseases for example celiac // Allergology and immunology. - 2000. No. 3. - Ñ.38-48.

5. Laboratory diagnosis of celiac disease. Emanuel V.L., vohmjanina NV, Revnova MO, Krasnogorsk I.N. Method recommendations. - SPb., 2004. - 25 S.

6. Morphological diagnosis of diseases of the stomach and intestines. - M., 1998. - 384 S.

7. Clinical immunology. Ed. Ehizacoloni. - M.: Medicine, 1998. - P.106-192.

8. Overgrown A.N., Karachevtseva T.V., Yasnohorodska V.G. and other Manual physiotherapy and physioprophylactics childhood diseases. - M.: Medicine, 1987. - 384 S. Finger M.A., Ivanov A.A. Intercellular interaction. - M.: Medicine, 1995. - S.43-51.

9. Ouran IE, Gulyaev V.Y., Obraztsova RG and other New variant of electrophoresis // Questions of balneology, physiotherap and and physical therapy. - 1983. No. 6. - P.15-18.

10. Parfenov A.I. Enterology. - M.: Triada-X, 2002. - S-420.

11. Puzyrev V.P. Genetics of multifactorial diseases: between past and future // Medical genetics. 2003. Vol.2. No. 12. S-508.

12. Puzyrev VP, Stepanov V.A., Nazarenko, S.A. Genomic studies of hereditary diseases and genetic diversity of Siberian populations // Molecular biology. 2004. V.38. No. 4. P.129-138.

13. Rout A., Brostoff J., Email Doctor Of Medicine / Immunology. TRANS. from English. - M.: Mir, 2000. - S-527. Tabolin VA, Mukhina YG, Belmer SV current views on the pathogenesis of celiac disease // Russian journal of gastroenterology, Hepatology, Coloproctology. 1996. N3. C.11-20.1.

14. Frolkis AV Coeliac disease // Diseases of the gastrointestinal tract and heredity. - SPb., 1995. - S-110.

15. Ulaschyk V.S., Lukomsky IV General physiotherapy. - Minsk: 2003. - 353 S.

16. Yankina G.N., Lukanina O., Didenko LI, Terentia A.A. Celiac disease in children // journal of gastroenterology and Hepatology. - 2003, No. 16-17. S-243.

17. Yankina G.N., Kondratiev H. R., Nazarenko, L.P., Lashkova E.V., Ishchenko D.A. health Status of children with celiac disease and their relatives // Siberian journal of gastroenterology and Hepatology. - 2004, No. 18 S-100.

18. Yankina G.N., Kondratiev H. R., Nazarenko, L.P., Lashkova E.V., Didenko LI, Veit E.A. Clinical-genealogical and immunological characterization of CE is eacii in children // 25 years the faculty of improvement of professional skill and retraining of specialists: Collection of scientific works. Edited by Prof. Lavorativo, Professor Vimalaprabha. Tomsk, 2004. S-106.

19. Dinarello C.A. Inflammatory cytokines: interleukin-1 and tumor necrosis factor as effector molecules in autoimmune diseases // Curr. Opin. Immunol, - 1991 - Vol.3 - p.941-948.

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21. Research, Cambridge. 2003. P.449-457.

Table 2
Dynamics of blood cytokines in children with celiac disease on a background of treatment (X±p) (PG/ml)
Indicator (PG/ml)Before treatment (n=25)After treatment (n=25)Healthy (PG/ml) n=20
IL 1B200,6250±33,4971131,0000±43,702318,07976±3,1
R1=0,049951p2=0,052962
R2=0,074951
IL124,7619±19,2554186,8750±25,960213,50843±2,7
pl=0,060059p2=0,042631
p2=0,059951
IL 6106,8182±13,7445100,5000±12,783112,68332±3,3
R1=0,492460R2=0,694317
R2=0,064951
TNF375,000±44,054290,476±33,73943,5368±5,6
R1=0,020659R2=0,041654
p2=0,039951
Note: R1the significance of differences before and after treatment (<0,05);
R2the significance of differences between patients (before and after treatment) and healthy (<0,05).

The method of complex treatment of children with celiac disease, including gluten-free diet, enzyme therapy and physiobalneotherapy aimed at relief of abdominal pain, dyspeptic syndrome, correction of immune status, characterized in that the prescribed gluten-free diet with the exception of cereals and additional appointment protein: meat 100.0 g, cheese 100.0 g or sour cream 100.0 g daily; m is Diamantina therapy includes assigning CREON dose of 10000 ME during the meal within 2 weeks; the physiobalneotherapy includes physical therapy (physical therapy) daily, 20-30 minutes, 21-24 days; circular shower under a pressure of 1.5-2 atmospheres with water temperature 36-35°C for 3-4 min, the procedure is carried out in the second half of the day, through the day, the course of 10-12 treatments; radon baths, water temperature 36°C 0,75 kBq/l, a day in the days free from the soul, for 8-10 minutes, at the rate of 8-10 procedures, and the procedure is carried out in the second half of the day; electrophoresis of a 50%aqueous solution of Dimexidum (±) on the projection the small intestine along the transverse method, the current density of 0.05 mA/cm2, current up to 5 mA, the exposure time is 12-15 minutes, at the rate of 10-12, every day the procedure is performed through 1-1,5 hours after eating, also a local impact on prescription BAHT in the first half of the day using red light therapy and infrared range of the BAT: VC-20, VC-22, F-36, Gi-4, symmetrically to the right and to the left, the technique of stable contact, the exposure time per point 1.5-2 min, the total time of exposure 9-12 min, daily, 10-12 procedures.



 

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2 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, urology, physiotherapy and to be used in the patients suffering from chronic pyelonephritis accompanied with chronic prostatitis and chronic cystitis. The method involves taking the mineral water of the Slavjanovsky source dosed 3 - 5 ml per kg of body weight, combined with carbonic mineral baths 35-37°C for 15 minutes 3 times a day, № 8-10, mud "panties" at 40-42°C within 30 minutes to 1.5 hours, prostate massage № 8-10, additionally 50-60 minutes later followed with electropulse therapy combined with exposure to laser magnetic rays. Electropulse therapy involves low-frequency, low-voltage pulse current with a spherical unipolar electrode. Exposure is contact, labile, clockwise and located at skin projection of ascending, transverse and descending large intestine at frequency 30.2 Hz within 8-10 minutes. The course of treatment is 10-12 procedures.

EFFECT: method improves life quality of the patients both in latent phase of inflammatory process, and in mild and moderate active chronic process.

2 ex, 2 tbl

FIELD: medicine.

SUBSTANCE: invention concerns ophthalmology and is intended for treatment of infectious diseases of a cornea. Photodynamic therapy with the use of gel containing an octacation phthalocyanine of zinc in concentration of 1-3 mg/ml, which is applied on a cornea as a photosensitinogen, is performed. The conjunctival cavity is washed out after 30 - 40 minutes and influenced with a laser radiation with a wavelength of 675 nm with a light dose 20 - 60 J/cm2 in of 5 minutes, once a day. 1-8 sessions during each course.

EFFECT: method allows destroying the originator of keratitis in a cell with the maximum safety of surrounding tissues of the cornea.

2 tbl, 3 dwg, 1 ex

FIELD: medicine.

SUBSTANCE: invention concerns medicine, namely, physiotherapy, reflexotherapy. Prior to the beginning of backbone extension acupuncture by the rule "Mother-son" is performed. In 3-5 days the backbone is simultaneously influenced with a magnetic-laser radiation and extension is performed. The magnetic-laser radiation influence is spent in red 630-650 nm and infra-red 890-950 nm ranges with 50 mT intensity of a magnetic field. Backbone extension is spent in mass of a load by 15-30 kg. Total time of the procedure makes 15-20 minutes.

EFFECT: method increases analgetic effect, reduces puffiness and improves microcirculation and trophicity of tissues.

1 ex

FIELD: medicine.

SUBSTANCE: invention concerns medicine and is intended for treatment of a diencephalic syndrome of the pubertal period. Influences by the physical factor on area of the eyes, traditional medicinal therapy, massage, hypohigh-calorie diet are performed. Influence is carried out by intermittent giving of electromagnetic waves of an optical range with a wavelength from 400 to 760 nm and duration of impulse from 1 till 8 seconds. Before each procedure for selection of a wavelength of influence the patient is suggested to choose the most pleasant to him at present colour from a range of lengths of waves from 400 to 760 nm, with an exception of those colours which are contraindicative to it according to accompanying diseases and prevailing semiology in a picture of its disease. Other parametres of the procedure - smooth or sharp increase of the intensity of light exposure, brightness, presence of pauses between flashes and additional illumination of area of eyes are selected before each procedure individually depending on sensitivity of the visual analyser of the patient to light exposure and rhythm choices. Influence by one colour in a prone position is carried out within 8 minutes. Influence is performed daily in first half of day. The course consists of 10 procedures.

EFFECT: offered way provides the best psychoemotional shipping of procedures with children, absence of fear before influence on eyes, absence of contraindications at allergic reactions to medicinal preparations, individual approach to each patient.

2 ex, 5 tbl

FIELD: veterinary.

SUBSTANCE: invention relates to field of veterinary. Method includes preliminary feeding medical herb flour to cattle on the background of main diet. After feeding with medical herb flour, cattle is subjected to single low-intensity magnet-laser exposure with semi-conductor laser "Isel-Victoria" on the region of spine from withers to tail attachment from both sides. Exposure is performed for 5-10 minutes from each side, for cows from distance 10-12 cm, for calves from distance 3-4 cm from middle sagittal line. Exposure is performed with the following radiation modes: wave length 0.85-0.89 mcm, laser impulse power 3.5 mW -5.0 W, pulse repetition frequency -50-80 Hz, energy dose - 0.002-0.024 J/cm2, power density - 0.1-0.3 mW/cm2 .

EFFECT: method allows to remove heavy metals from cattle organism in short time.

3 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to dermatology and cosmetology and can be used for treatment of such skin disease as rosacea. For this purpose Doppler examination of face skin microcirculation is carried out, during which background volume rate of tissue blood flow on affected and unaffected sections of face skin is determined with further comparison of obtained parameters with each other. In case compared parameters have deviation value not less than 10%, base care of face skin is prescribed: use of purifying and moisturising preparations for sensitive skin, microcurrent therapy in lymphodrainage mode for 20 minutes 2-3 tines a week with course of 8-10 sessions, and introduction of Sulodexide 250 LSU after meal with 4-8 week course. In case compared parameters of background volume rate of blood flow have deviation value from 10 to 20% in case of papula-pustular stage of rosacea, course of microcurrent therapy in lymphodrainage mode is carried out 3 times a week with course consisting of 10 sessions, and Sulodexide is introduced with course of 4 weeks. In case compared parameters of background volume rate of blood flow have deviation value from 20% and greater, rosacea stage being hypertrophic, Sulodexide is introduced with course of 8 weeks, and microcurrent therapy in lymphodrainage mode is carried out from 4th week 3 times a week with course consisting of 10 sessions in combination with basic care of face skin.

EFFECT: method allows ensuring stable therapeutic effect including treatment of severe forms of rosacea due to complex influence.

3 cl, 2 ex

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