Method of pyelonephritis prevention in experiment
SUBSTANCE: invention relates to experimental medicine and concerns pyelonephritis prevention in experiment. During 10 days preparation "Ultrasorb" is introduced to experimental animals with food in terms of 3 g/day. Then pyelonephritis is modelled by rectal infection with uropathogenic strain of lactose-negative E.Coli at the background of cold stress.
EFFECT: absence or reliable reduction of kidney tissue inflammation in animals which obtained "Ultrasorb".
The invention relates to medicine, namely to Nephrology and experimental medicine, and can be used for the prevention of pyelonephritis in experimental animals (white rats) and develop a way to prevent exacerbation of pyelonephritis in humans.
In the available scientific and patent literature methods of prevention of pyelonephritis in vivo was not found.
The invention is directed to solution of the problem: create a method of prevention of pyelonephritis in experimental animals, resulting from migration of intestinal autoflora into the systemic circulation as a result of acute stress on the background of violations of microbiocenosis of intestines due to improper feeding animals (violation-mode power supply, replacement in the diet of some other products, lack of vitamins in the diet) or artificially created intestinal dysbiosis (Berdichevsky, B.A. et al., 1993, Wmmintrin.h, 2007). You can use a method to prevent acute pyelonephritis patients.
Effect: prevention of pyelonephritis in experimental animals to develop a way to prevent exacerbation of pyelonephritis in humans.
These objectives are achieved by prophylactic use in experimental animals (white rats) t is the within 10 days of preparation "Ultrasorb" at the rate of 3 g/day, mixing it with food. Biologically active additive "Ultrasorb" issued by CJSC "Berry", Kirov, Dugino. The drug is used as a preventive measure practically healthy people when exposed to adverse environmental and production factors, with the increased risk of the formation of goiter, cancer, diabetes, immune deficiency. Also the drug is used alone or as a part of complex therapy in diseases of the gastrointestinal tract (stomatitis, dysbiosis, acute intestinal infections, ulcer of stomach and duodenum, gastritis, cholecystitis, hepatitis, enteritis, colitis), metabolic disorders (atherosclerosis, obesity, diabetes, hyperglycemia), alcohol intoxication and alcoholic pathology in inflammatory pathologies of the skin from bacterial and allergic origin in the complex therapy of secondary immune deficiency.
For the prevention of pyelonephritis this drug is not used.
The main component of "Ultrasorb are fermented insoluble and soluble dietary fiber, which helps to normalize the intestinal microflora, which in turn leads to the strengthening hepatointestinal barrier and prevents tra is socaciu conditionally pathogenic flora of the intestine into the bloodstream.
The method is as follows. The drug "Ultrasorb" after mechanical grinding in a mortar and added to feed for experimental animals (white rats) in an amount of 0.1 (10%) of the daily volume of food (30 g/day per animal, according to the existing norms) 3 g/day. Prophylactic use of the drug "Ultrasorb" is 10 days.
The experiment was performed at 25 animals male and female outbred white rats four months of age contained in standard vivarium conditions. All experiments were conducted in accordance with "the Rules of work with the use of experimental animals" (Annex to order of the Ministry of health of the USSR from 12.08.1977, N755) and the European Convention for the protection of vertebrate animals used for experimental and other scientific purposes" dated March 18, 1986
Animals were divided into 5 experimental groups: control group 2 experimental group not receiving treatment, group 2, treated as an experimental drug therapy "Ultrasorb". Pyelonephritis in animals of the experimental groups was modeled by rectal infection uropathogens lactose-negative strain of Escherichia coli with subsequent single stress exposure in the form of acute cold stress. To infect animals were used in the days the s broth culture uropathogenic strain of Escherichia coli at concentrations of 10 9and 106CFU/ml determined values method.
Group I - control (intact animals), n=5;
Group II - infected Escherichia coli at a concentration of 109CFU/ml with subsequent stress exposure in the form of acute cold stress, n=5;
Group III - infected Escherichia coli at a concentration of 106CFU/ml, also followed by cold stress, n=5;
Group IV - infected Escherichia coli at a concentration of 109CFU/ml, cold stress, giving the drug "Ultrasorb" within 10 days prior to infection and during the subsequent experiment, n=5;
Group V - infected Escherichia coli at a concentration of 106CFU/ml, cold stress, giving the drug "Ultrasorb" within 10 days prior to infection and during the subsequent experiment, n=5.
All experimental animals treated with prophylactic drug "Ultrasorb" and subjected to rectal infection uropathogenic Escherichia coli, and then acute cold stress (groups IV and V)were not significant changes in the peripheral blood during the experiment. When conducting bacteriological studies of autopsy material culture of Escherichia coli, identical in properties taken for rectal infection with the strain was isolated in a significantly smaller percentage of cases compared to animals infected with the rectal same strain, but not receiving "Ultrasorb" (P<0.001). When carrying out histological studies of autopsy material in animals treated with prophylactic treatment "Ultrasorb", inflammatory changes in the kidneys were expressed minimal or absent, whereas in kidneys of animals not receiving "Ultrasorb", attended expressed signs of pyelonephritis: limfomonotsitoza infiltration of the renal pelvis and interstitial kidney, degenerative changes in the tubules.
Examples of specific performance.
Example 1. The female white rats weighing 130 g for 10 days in a mixture with feed gave the drug "Ultrasorb" in the amount of 3 g/day. On the 11th day of the experiment under ether anesthesia the animal rectal introduced 500 µl of bacterial suspension daily broth cultures of clinical isolates uropathogenic lactose-negative Escherichia coli at a concentration of 106CFU/ ml On the next day after infection, the animal was subjected to a single stress exposure - cooling to t°=+4°C for two hours.
Subsequent studies of peripheral blood of the animal, held on the 3rd and 7th days after rectal administration culture, revealed no significant deviations of parameters from baseline. When conducting bacteriological studies of autopsy material of the seed of the studied organs not received the. When conducting histological examination revealed no inflammatory infiltrates in the interstitium and renal pelvis.
Example 2. The female white rats weighing 146 grams for 10 days in a mixture with feed gave the drug "Ultrasorb" in the amount of 3 g/day. On the 11th day of the experiment under ether anesthesia the animal rectal introduced 500 µl of bacterial suspension daily broth cultures of clinical isolates uropathogenic lactose-negative Escherichia coli at a concentration of 109CFU/ ml On the next day after infection, the animal was subjected to a single stress exposure - cooling to t°=+4°C for two hours.
Subsequent studies of peripheral blood of the animal, held on the 3rd and 7th days after rectal administration culture, revealed no significant deviations of parameters from baseline. When conducting bacteriological studies of autopsy material culture of Escherichia coli, the properties are identical to those used to infect strain, was isolated from the kidneys, spleen and liver of rats at a concentration of 102CFU/g When carrying out histological studies revealed scant inflammatory infiltration in the mucosa and stroma renal pelvis.
Example 3. The female white rats weighing 150 g for 10 days in a mixture with feed gave the drug "Ultrasorb" in the amount of 3 g/day. the as of the 11th day of the experiment under ether anesthesia the animal rectal introduced 500 µl of bacterial suspension daily broth cultures of clinical isolates uropathogenic lactose-negative Escherichia coli at a concentration of 10 9CFU/ ml On the next day after infection, the animal was subjected to a single stress exposure - cooling to t°=+4°C for two hours.
Subsequent studies of peripheral blood of the animal, held on the 3rd and 7th days after the rectal Vvedenie culture, revealed no significant deviations of parameters from baseline. When conducting bacteriological studies of autopsy material of the seed of the studied organs not retrieved. When conducting histological examination revealed no inflammatory infiltrates in the interstitium and renal pelvis.
Example 4. Anesthetized with ether female white rats weighing 140 g introduced rectally once with 500 µl bacterial suspension daily broth cultures of clinical isolates uropathogenic lactose-negative Escherichia coli at a concentration of 10 CFU/ ml On the next day after infection, the animal was subjected to a single stress exposure - cooling to t°=+4°C for two hours.
3 days after exposure to stress in the peripheral blood of the experimental animal found a significant increase of leukocytes, continuing until the conclusion of animal experiment. On the 10th day the animal was killed under ether anesthesia by transection of the spinal cord, conducted bacteriological and histolo the systematic examination of the internal organs.
When conducting bacteriological studies of autopsy material culture of Escherichia coli, the properties are identical to those used to infect strain, was isolated from the kidneys, spleen and liver of rats at a concentration of 2*106CFU/g When conducting pathological studies of the colon and small intestine in the stroma of the villi revealed infiltration by lymphocytes, neutrophils and macrophages, with a predominance of lymphocytes. In the kidneys of experimental animal found infiltration interstice by leukocytes, lymphocytes and macrophages, the plethora of vessels, granular degeneration of the epithelium of the tubules and protein cylinders in their gaps, inflammatory lymphohistiocytic infiltration with admixture of neutrophils in the mucosa and stroma renal pelvis. The revealed changes indicate the development of the animal acute pyelonephritis.
The positive effect of using the proposed method consists in preventing pyelonephritis in experimental animals on the background of violations of the composition of the intestinal microflora, resulting from improper feeding of animals.
Method of prevention of pyelonephritis in the experiment, which consists in the fact that the experimental animals with impaired intestinal microflora composition, within 10 days to give the drug, "Ultrasorb" from the calc is 3 g/day, mixing it with food.
SUBSTANCE: invention relates to medicine, namely to pediatrics and gastroenterology and can be used for treating intestine disbacteriosis in children less than 1 year old. For this purpose bifidumbacterin forte is introduced. First 2-3 days preparation is introduced by 25-30 doses per day in 4 takings. During next 3-4 weeks bifidumbacterin forte is introduced by 5 doses 2 times a day.
EFFECT: method allows increasing efficiency of treatment of disbacteriosis in children less than 1 year old due to application of definite scheme of preparation introduction first in optimally high dose mode, then in supporting doses.
SUBSTANCE: invention relates to medicine, in particular to gastroenterology, and applies to treatment of chronic duodenal obstruction. For this purpose erithromicin is introduced on account of 3.0 mg/kg of body weight 3 times a day. Additionally Alfadol-Ca is introduced in case of initial normocalcemia in dose 1 capsule 1 time a day. In case of initial hypocalcemia Alfadol-Ca dose is 1 capsule 2 times a day. Course of treatment is 3 months.
EFFECT: method ensures elimination of symptoms of chronic duodenal obstruction in patients with functional form of chronic duodenal obstruction in combination with syndrome of disturbed absorption and normalisation of calcium balance in organism.
2 dwg, 1 tbl, 2 ex
FIELD: medicine; gastroenterology.
SUBSTANCE: antibacterial therapy is presented with selective decontamination using antiklebsiellic bacteriophage within 10 days. After that prebiotic therapy including Hylak Forte, enzymatic agent and Linex in therapeutic dosage is combined with probiotic introduction. For dysbacteriosis of I stage Bifiform is introduced in dose 1 capsule 2 times a day, for dysbacteriosis of II and III stages dose is 2 capsules 2 times a day, combined with Lactobacterinum 5 doses once a day. Thus medicinal plant tincture is introduced including silverweed rootstock, salvia leaves, milfoil herb, St. John's wort herb, elecampane rootstock with roots, tickseed herb, mint leaves, fennel fruits and buckthorn bark at component ratio respectively 2:2:2:2:2:2:2:2:1 dosed 1\3 of glass 3 times a day, 30 min before meal, within 4 weeks.
EFFECT: method has no contraindications and provides fast normalisation of gastrointestinal tract microflora.
1 tbl, 1 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention concerns medicine. A soft drink on the basis of herbs consists of the concentrated vegetative extract obtained from an admixture of herbs, chosen of Sida sps., Boerhaavia diffusa, Vitis vinifera, Tinospora cordifolia and Withania somnifera, along with green palm sugar, the agent causing a fermentation, and carbonised water, in which proportion Sida sps.: Boerhaavia diffusa: Vitis vinifera: Tinospora cordifolia: Withania somnifera in a powdery admixture makes (15-20 : (5-10 : (15-20 : (5-10 : (5-10); Proportion of wt/wt: green palm sugar: the concentrated vegetative extract makes from 1 : 3 to 1 : 4; wt/wt, a proportion of carbonised water: the admixture of the concentrated vegetative extract, green palm sugar and the agent causing a fermentation, makes from 1 : 3 to 1 : 5. Perform: (a) obtaining of parts of Sida sps., Boerhaavia diffusa, Vitis vinifera, Tinospora cordifolia and Withania somnifera; (b) crushing of parts of plants and their mixing with obtaining of a powdery admixture; (c) water addition to a powdery admixture from a stage (b) for obtaining of a water extract; (d) concentration of a water extract from the stage (c); (e) filtration of the concentrated extract from the stage (d); (f) admixture of green palm sugar to the filtered extract from the stage (e); (g) addition of Sacromyces strain and the agent causing fermentation, to the admixture from the stage (f); (h) fermentation of the admixture from the stage (g) during the period of time from 3 till 6 days; (i) filtration of the fermented admixture from the stage (h); (j) concentration of the fermented filtrate from the stage (i) with obtaining of the basic solution and (k) mixing of the basic solution (j) with the carbonised water in wt/wt proportion from 1 : 3 to 1 : 5 with obtaining of a soft drink on the basis of herbs.
EFFECT: creation of a soft drink on the basis of herbs.
11 cl, 5 tbl, 8 ex
FIELD: medicine; pharmacology.
SUBSTANCE: invention concerns production of herbal tea for prevention and complex treatment of intestinal disbacteriosis. The herbal tea includes cinquefoil rootstocks, salvia leaves, milfoil grass, St. John's wort grass, elecampane rootstock and roots, sticktight grass, mint leaves, fennel fruit and buckthorn bark in the ratio of 2:2:2:2:2:2:2:2:1 respectively.
EFFECT: extended medicine range for prevention and complex treatment of intestinal disbacteriosis by sanitation of opportunistic intestinal microflora.
FIELD: medicine; pharmacy.
SUBSTANCE: first version implies that pharmaceutical formulation contains antibiotic and prebiotic - oligosaccharide selected from: fructooligosaccharides, galactooligosaccharides, xylooligosaccharides, maltooligosaccharides and isomaltooligosaccharides by degree of polymerization from 2 to 10, and particles sizes up to 0.3 mm and purity not less than 95%, and antibiotic with particles sizes from 20 to 200 mcm; antibiotic and oligosaccharide are included in mass proportion from 1:1 to 1:100 respectively. Second version implies that pharmaceutical formulation contains powder antibiotic with particles from 20 to 200 mcm selected from: beta-lactamase, including combinations of beta-lactams and bacterial beta-lactamases inhibitors; azalides, fluoroquinolones, amphenicoles, glycopeptides, ansamicynes, nitrofurans, phosphonic acid derivatives, cycloserine, trimetoprym, and as a prebiotic - powder oligosaccharide by degree of polymerization from 2 to 10, particles sizes up to 0.3 mm and purity not less than 95%; antibiotic and oligosaccharide are included in mass proportion from 1:1 to 1:100 respectively; mentioned compositions are intended for oral introduction and applied for bowel disbios prevention caused by antibiotic therapy.
EFFECT: stimulates lactobacilli and bifidus bacteria action.
4 cl, 9 ex
SUBSTANCE: method involves introducing ozonized physiologic saline once a day during 30 min in addition to traditionally applied drugs. The ozonized solution has ozone in concentration of 100-150 mcg/l in the amount of 100-150 ml when treating children younger than 3 years. Children being elder then 3 years, ozone concentration is 200-250 mcg/l, its amount is 200-250 ml. The total therapy course is 5 days long. The traditionally applied drugs are not to be used within 30 min before and after ozonized physiologic saline application.
EFFECT: accelerated treatment course; no antibiotics being used; reduced risk of adverse side effects.
FIELD: medicine, biochemistry, pharmacy.
SUBSTANCE: invention relates to drugs used in treatment and prophylaxis of diseases associated with deficiency or absence of enzyme lactase in human body. Agent comprises enzyme lactase isolated from cultural fluid of microscopic fungus Penicillium canescens with activity 10000 U/g, not less, and shows stability in the pH range from 2.5 to 7.0 and temperatures from 4°C to 60°C. Agent provides effective cleavage of lactose in milk and dairy foodstuffs to a mixture of easily assimilable monosuccharides: glucose and galactose that results to availability of dairy foodstuffs for their using by humans suffering from lactose intolerance. Enzyme is stable that allows its using both for dosing orally with simultaneous using dairy foodstuffs and for their preliminary treatment.
EFFECT: valuable medicinal and nutrient properties of agent.
2 cl, 2 tbl, 2 dwg, 2 ex
SUBSTANCE: method involves applying dietotherapy containing nutrient fibers at a dose of 10-20 g/day. De-nol is additionally introduced at a dose of 120 mg 3-4 times 30 min before taking meals and Mezyme forte at a dose of 1 tablet 3 times a day while eating.
EFFECT: enhanced effectiveness in normalizing intestinal flora; reduced number of adverse side effects; excluded disease recurrence.
FIELD: medicine, pharmacology, biochemistry, enzymes.
SUBSTANCE: invention relates to an enzyme-containing medicinal agent wherein enzymes are chosen from a group consisting of hydrolases, lipases, amylases, glycosidases, phospholipases, phosphodiesterases, phosphatases prepared from infusoria. Also, invention relates to a method for using indicated enzymes in improving digestion or in treatment of digestion disorders. Invention enhances resistance to stomach acid media and preparing from safety microorganism.
EFFECT: valuable medicinal properties of enzymes.
7 cl, 2 tbl, 7 dwg, 2 ex
SUBSTANCE: method concerns medicine, namely to endocrinology, and concerns treatments of a diffusive euthyroid struma. For this purpose the complex therapy including Iodidum of potassium is carried out - in a dose of 200 mkg/day, sodium selenate - in a dose - 150 mkg/day and Rekicene RD in a dose 10 g 3 times a day.
EFFECT: such complex of medicamental therapy provides effective pathogenetic treatment at the expense of a restore of deficiency of necessary trace substances in a combination to a selective sorption of salts of serious metals, arsenic and other potential goitrogens.
4 tbl, 1 ex
FIELD: medicine; intensive care.
SUBSTANCE: for combined injury and blood loss patients, tube feeding with balanced nutrient mix is conducted in 24 to 36 hours of hospitalisation. The mix is introduced dropwise, 500 ml during first 24 h at rate 25-50 ml/h, 1000 ml during the second day at rate 75-100 ml/h. On following days the mix is introduced in quantity 1500 to 2000 ml at rate 100-150 ml/h. Feeding is continued until swallowing is gained and the patient is capable to eat by himself.
EFFECT: reduction in cytogenetic abnormalities, induced by severe injury and blood loss, due to early nutritive maintenance.
1 tbl, 1 ex
FIELD: medicine; veterinary.
SUBSTANCE: medicine includes metal iodine and potassium iodide, prolongator and water. 1,2-propylene glycol is used as prolongator, and additionally vitamin A (retinol acetate), vitamin E (alpha-tocopherol acetate), vitamin B1 (thiamine hydrochloride), vitamin B2 (riboflavin), vitamin B6 (pyridoxine hydrochloride), vitamin B12 (cyanocobalamin), iron carbonate, magnium phosphate, manganese sulfate, copper sulfate, zinc sulfate, cobalt chloride, sodium chloride, amber acid, glucose, rectified ethyl alcohol (96%) are applied. Medicine components are taken at the following rate, g/100 ml of distilled water: metal iodine, chemically pure 0.112-0.187; potassium iodide, R 0.337-0.562; vitamin E (alpha-tocopherol acetate) 0.060-0.100; vitamin A (retinol acetate) 3.750-6.250 thousand mass units; vitamin B1 (thiamine hydrochloride) 0.052-0.087; vitamin B2 (riboflavin) 0.037-0.062; vitamin B6 (pyridoxine hydrochloride) 0.034-0.056; vitamin B12 (cyanocobalamin) 0.026-0.044; iron carbonate, R 0.337-0.562; magnium phosphate, R 0.337-0.562; manganese sulfate, R 0.172-0.287; copper sulfate, R 0.090-0.150; zinc sulfate, R 0.315-0.525; cobalt chloride, R 0.071-0.119; sodium chloride, R 0.589-0.981; amber acid, primary standard 0.225-0.375; glucose, AR 0.172-0.287; rectified ethyl alcohol (96%) 0.300-0.500 ml; 1,2- propylene glycol 0.900-1.500 ml. Method involves medicine administration with fodder in dosage of 1.00-1.50 mg per 1 kg of fish weight once per day for 5-7 days.
EFFECT: correction of needs for bioactive substances, prevention of avitaminosis, achievement of high antioxidant organism protection level, prevention of accumulation of non-saturated fatty acid peroxides harmful to fish.
2 cl, 3 tbl, 3 ex
FIELD: medicine; veterinary medicine.
SUBSTANCE: remedy contains, wt %: 48.5-51.5 of iodinebismuthsulphamide and 51.5-48.5 of biopolymer. The biopolymer is produced by means of urea, Formalinum and Glycerinum interaction at temperature of reactionary mass 85-87°C with the subsequent injection of 50% polyvinylpyrolidone solution, at a relative component proportion, wt %: 19.8-20.2 of urea; 19.8-20.2 of Formalinum; 39.5-40.5 of Glycerinum; 4.5-5.5 of distilled water; 4.5-5.5 of polyvinylpyrolidone. The target product combines properties of antiseptic and film covering. The preventive effect is ensured by means of application on papillas skin and papillary aperture area.
EFFECT: increase of remedy preventive efficiency cost reduction of animal treatment.
3 tbl, 7 ex
FIELD: medicine; endocrinology.
SUBSTANCE: lowered caloric content diet #5 is prescribed, in combination with fasting days 2 times a week with caloricity of 1000-1200 kilocalorie per day. Therapeutic physical training with individual exercise dosage is carried out daily in the first half the day for 30-40 minutes, within 21-24 days. The general manual massage is alternated by days with Charcot's douche, during the course of 8-10 procedures. A Charcot's douche effects the back thigh surface , buttocks, frontal abdominal wall - clockwise at pressure of 1.5-2 atmospheres, water temperature of 36°C, 0.5-1 minute per zone, total effect time is 4 minutes. The procedure is caried out in the second half of the day, in the course of 10-12 procedures. Electrosleep is carried out by oculo-cervical method at frequency of 10-20 Hz, current intensity up to 1-2 mA, exposure time is 30 minutes. Besides the procedure is carried out in the middle of the day, daily, in the course of 10-15 procedures. Group and individual appointments with the psychologist are carried out on the daily basis, during 45-60 minutes, within 21-24 days. Patients with combination of obesity and struma in addition are provided with iodide-bromine baths with iodine concentration of 10 mg/l, Bromum of 25 mg/l, water temperature is 37°C, procedure duration is 8-10 minutes, alternating by days with Charcot's douche, in the course of 8-10 procedures. The general massage is carried out at the same day with iodide-bromine baths, iodbalance intake is 100-200 mkg/per day, daily, after meal. In case of psychocorection additional activities are done for formation of motivation, loss of weight and long-term iodine drugs intake, reduction of anxiety, aggression and increase of self-appraisal.
EFFECT: body weight reduction, normalisation of arterial pressure, increase of exercise tolerance, correction of metabolic, hormonal and vegetative status parameters.
7 tbl, 2 ex
SUBSTANCE: present invention concerns medicine and describes the liquid antimicrobial composition containing (1) admixture of iodide anions and thiocyanide anions, thereat weight ratio of iodide anions to thiocyanide anions makes from 0.2:1 to 20:1; (2) periodide acid or its salt; and (3) at least, one polymer or a copolymer containing in quality of monomeric units (a) 5-100 wt %, of at least one monoethenoid saturated monomer containing nitrogen - and-or phosphorus-containing groups, (b) 0-95 wt %, of at least, one monoethenoid saturated comonomer, containing acid groups, (c) 0-75 wt %, of at least, one additional comonomer, chosen from the group including monoethenoid saturated monomers, distinct from (a) and (b), and monomers, free from ethylene saturated groups, suitable for formation of polyaethers, and (d) 0-5 wt % of cross-linking comonomers, containing, at least, two ethylene saturated groups.
EFFECT: rising of term of stability and long-term system effectiveness due to including of synthetic polymers and copolymers.
1 tbl, 1 ex, 6 ex
SUBSTANCE: method involves carrying out balneotherapy, foing physiotherapy exercises and intaking iodomarine and/or L-tiroksin. In first half of the day, physiotherapy exercises are performed, general artificial radon baths being performed in the second half of the day. Manual massages of a collar zone are perform in days free from baths. From November till March phonophoresis of Traumel S ointment on a thyroid gland projection is also performed with an intensity of 0.05 W/cm2, continuous regimen, duration of influence of 3-5 minutes on the right and at the left, general time of influence of 6-10 minutes, in a day with a magnetotherapy on a projection of palatine tonsils, size of a magnetic induction being 6-9 mT, for 5-6 minutes from each party, general time of 10-12 minutes, in a course of 8-10 procedures. At treatment during the period from April till October, patients are additionally prescribed a group galotherapy in the second half of the day, in a course of 10-15 procedures, and phototherapy of red range at a wavelength of 660-675 nanometers, densities of power of radiation of 1 mW/cm2 and an infra-red range at a wavelength of 840-950 nanometers, densities of power of radiation of 2.7 mW/cm2 to biologically active points: VC-20, VC-22, E-36 symmetrically on the right and the left, Gi-4 symmetrically on the right and the left. Time of influence for one point is 1.5-2 minutes, general time of influence being 9-12 minutes, daily, in 10-12 procedures, with duration of treatment making up 21-24 days.
EFFECT: decrease of exacerbations of chronic centres infection frequency; normalising action on the immunologic status during the most adverse periods of a year and maintenance of a condition of euthyroidism within all year.
3 tbl, 2 ex
FIELD: medicine; pharmacology.
SUBSTANCE: invention refers to pharmaceutical formulation applied for metastasis prevention and increasing of malignant hormone-dependant tissue tumour sensitisation to chemotherapeutic agents. Proposed oral pharmaceutical composition contains as active agents indole-3-carbinole, epigallocatechine-3-gallate and mineral premix including copper sulphate or gluconate, potassium or sodium iodide, iron lactate, sodium selenite, zinc sulphate or oxide, manganese sulphate or carbonate taken at specified ratio.
EFFECT: prevention of metastasis accompanying malignant tumour and increasing of tumour sensitisation to chemotherapeutic agents.
3 cl, 5 ex, 3 dwg
FIELD: medicine; pharmacology.
SUBSTANCE: invention concerns medicinal agent applied for various dermal diseases, injuries, stab, cut and septic wounds, burns and frostbites. Stated medicinal agent is antiseptic ointment containing iodophor as reactant, and polyethylene glycol as ointment base. As iodophor stated ointment contains pharmaiodine, and as ointment base - mixed polyethylene oxide-1500, polyethylene oxide-400 and glycerine taken in proportions as follows, (mass.%): pharmaiodine 5.0-20.0 (0.5-2.0 by active iodine); polyethylene oxide -1500 35-40; glycerine 15-17; polyethylene oxide-400 and other components to 100.
EFFECT: ointment is characterised by antiseptic, anti-inflammatory and wound healing action.
FIELD: medicine; dental surgery.
SUBSTANCE: for this purpose first of all root canals are filled with paste based on eugenol, zinc oxide, dry iodoform and lincomycin hydrochloride taken in ratio 3:3:1:1. Then cortical plate trepanation and cyst membrane extraction are followed with ultrasonic treatment of bone cavity through 0.05% miramistine within 5 minutes using ultrasonic device US-102 at exposure intensity 0.05-0.4 Wt/cm in pulse mode. Treated bone cavity is introduced with filling-bandage "Collost" and with mixed osteoplastic gel "Collost" and lincomycin hydrochloride taken in ratio 2:1, and is covered with membrane "Collost". Wound is isolated from mouth cavity with film "Dyplene-denta" with lincomycin.
EFFECT: enables to accelerated wound healing process due to complete osteointegration and angioosteogenesis of implanted material.
SUBSTANCE: invention concerns medicine, obstetrics and rehabilitation and can be applied in diagnostics and treatment of water balance disorder for pregnant women. Water balance disorder type is defined for patient. For I type characterised by 'empty' vessels and hydropic interstition, hypokinetic blood circulation type, average venous hematocrit indicators of 39% or over, low average peripheral hematocrit indicators of 34% or lower and hematocrit indicator difference over 3%, differentiated infusion therapy is performed, with infusion therapy volume calculated with account of circulation blood volume (CBV) increase expected for healthy woman at second or third trimester, equal to 40% or 30% respectively, and of indicators of dependency between original body weight before pregnancy and infusion therapy volume rated per 1 kg of body weight by nomogram No 3. Infusion therapy includes 10% refortan in dosage selected for each pregnant woman with account of her original body weight and pregnancy term by nomogram No 2 and glucose and magnesium mix in amount of 400 ml: 325 ml of 20% glucose solution and 75 ml of 25% magnesium sulfate solution. Infusion therapy volume is calculated so as liquid volume combined with water consumed in one day time comprises normal CBV increase for second or third trimester. For II type characterised by 'empty' vessels and 'dry' interstition, transsudate presence in peritoneal cavity, uterus and parenchymic tissue edema, hyperkinetic blood circulation type, venous and peripheral hematocrit indicators of over 43% and 42% respectively and their difference not larger than 2%, infusion therapy similar to that of I type is performed, with addition of saline solution in volume corresponding to water-binding properties of 10% refortan. For III type characterized by total hyperhydration, hypo- or hyperkinetic blood circulation type, average venous and peripheral hematocrit indicators of under 35% and 33% respectively and their difference not larger than 2%, dehydration therapy by lasiks and euphillin microdosage is performed, III type is transformed into I type, and infusion therapy corresponding to I type is performed with a single difference in total liquid volume administered in one day time, reduced in connection to hypervolemia by value equal to water amount, which can be drawn to vessel course by refortan.
EFFECT: improved treatment results for pregnant patients with water balance disorder by development of differentiated infusion therapy with account of pathological water and original body weight redistribution type both before and after labour, thus reducing number of lethal outcome.
6 tbl, 3 dwg, 3 ex