Method of neoadjuvant chemoradiotherapy in patients suffering from thoracic esophagus cancer
SUBSTANCE: invention refers to medicine, oncology and to be used for neoadjuvant chemoradiotherapy in the patients suffering from thoracic oesophagus cancer. Said therapy is ensured by introduction of cisplatin and leucovorin, and continuous intravenous infusions of fluorouracil dosed 300 mg/m2. Cisplatin solution is introduced intravenously drop-by-drop and dosed 6 mg/m2 daily once a day within 1 hour. Leucovorin is injected intravenously jet-like and dosed 30 mg/m2. Radiotherapy involves daily fractions 3 Gy to total basic dose 30 Gy. The course dose of fluorouracil is 3600 mg/m2, of cisplatin is 72 mg/m2, of leucovorin 360 mg/m2. Chemotherapy and radiotherapy are to be started the same day.
EFFECT: disclosed method allows for considerably reduced toxicity of treatment to be continuous, treatment of the patients originally of bad performance status, for doubly reduced time of neoadjuvant treatment with maintaining high clinical effectiveness.
The invention relates to medicine, namely to the combined use of chemotherapy and radiotherapy, and is intended to enhance the antitumor effects of radiation therapy in the neoadjuvant regimen in patients with cancer of the thoracic esophagus.
Increasing the resectability in patients with cancer of the thoracic esophagus and attempt to improve long-term outcomes contribute to the emergence of new antitumor combinations, including through a combination of radiation therapy and chemotherapy.
The basis for selection of chemotherapy in combination with radiation therapy was two works from Japan [1, 2], which were given high immediate results of treatment with low toxicity due to prolonged administration of cytostatics. The authors have introduced neoadjuvant the drug 5-fluorouracil as a continuous infusion at a dose of 250 mg/m2, cisplatin 5 mg/m21 hour before radiotherapy, leucovorin (30 mg/m2. Then radiotherapy was performed on the region of the esophagus 2 Gy per day to a total dose of 40 Gy.
However, this method of chemoradiation treatment has a number of disadvantages. First, the radiation therapy in the traditional mode of fractionation at a dose of 40 Gy in 4 weeks followed by a break in treatment for 2-3 weeks needed for ku is investing radiation reactions, is long enough (about 6-7 weeks), which requires additional costs for hospitalization and delays the timing of surgical treatment. Secondly, the prolonged introduction of drugs during this period is poorly tolerated by patients, which significantly reduces the quality of life.
The aim of the invention is the reduction of toxicity, as a consequence, the possibility of treatment for patients in poor General status (Karnofsky index = 70%); the reduction of treatment time; the length of hospitalization, while maintaining the high efficiency of treatment.
This goal is achieved by the introduction of mode fractionation radiotherapy at a total dose of 30 Gy at 3 Gy per fraction, 5 times a week for 2 weeks and by reducing the duration of treatment up to 3 weeks, increasing doses of cytostatics, enter daily: cisplatin 6 mg/m2, fluorouracil at a dose of 300 mg/m2, leucovorin (30 mg/m2.
The mentioned combination and sequence of distinctive actions are not known and are not derived explicitly from the current level of science and technology, therefore, the inventive method corresponds to inventive step.
The method is as follows.
After the examination to clarify the stage of the disease and obtain morphological confirmed what I cancer of the thoracic esophagus before treatment all patients perform catheterization of the subclavian vein by the Seldinger. Begin ongoing (hour), long-term (throughout the course of radiation therapy) intravenous fluorouracil at a dose of 300 mg/m2a day via infusion pump. Heading dose of 3600 mg/m2. In parallel with the introduction of fluorouracil, once a day, daily, intravenously, within 1 hour injected cisplatin 6 mg/m2400 ml of 0.9% saline solution. Heading dose of 72 mg/m2. Once a day (before radiation therapy, intravenous, jet within 3-5 min, administered leucovorin (30 mg/m2. Heading dose of 360 mg/m2. Chemotherapy and external beam irradiation start in one day. Within 30-60 min after injection drugs all patients receive external beam irradiation for breast esophagus, paraesophageal tissue and lymph nodes of the mediastinum with a single focal dose of 3 Gy, 5 times a week up to a total focal dose of 30 Gy. 7-10 days after the end of treatment check-up examination and perform surgical treatment in the amount Subtotal resection of the esophagus. The General term neoadjuvant treatment is 21-24 days.
Said treatment conducted in 27 patients with cancer of the thoracic esophagus, which in neoadjuvant mode conducted simultaneous production of the radiation treatment by the proposed method, thanks to all the patients received treatment in full, without interruption, toxic reactions of III degree was not observed. Reduction of toxicity has made possible the treatment of some patients with Karnofsky index = 70%. Reduced treatment time from 6-7 weeks to 3 weeks. The immediate effectiveness of the treatment was 70.4%, taking into account the stabilization of the tumor process - 100%.
Here are clinical examples of the use of the method.
Example 1. Patient P., aged 63, clinical diagnosis: Cancer of the middle third of the thoracic esophagus T3N0M0 IIA Art. Dysphagia III Art. the Histological conclusion squamous cell carcinoma moderate degree of differentiation. According to the survey, the length of the tumor in the esophagus was 3 cm, soft tissue component by x-ray 2,5 see as neoadjuvant chemoradiation treatment of the patient was performed radiation therapy in total ML 30 G, were carried out in parallel infusion of cytotoxic drugs: cisplatin 6 mg/m2, leucovorin (30 mg/m2bolus, fluorouracil at a dose of 300 mg/m2in a continuous infusion throughout the duration of radiation therapy (12 days). Complication - nausea II. Through 7 days after the end of chemoradiation therapy performed x-ray and endoscopic examination, which did not reveal the presence of a tumor in the esophagus. E is e after 3 days the patient was performed Subtotal resection of the esophagus with simultaneous formation of the esophago-gastric anastomosis in the neck. The histological conclusion therapeutic pathomorphosis of the fourth degree. The patient was discharged in satisfactory condition.
Example 2. Patient W., 52 years, clinical diagnosis: Cancer of the middle and lower third of the thoracic esophagus T3N0M0 IIA Art. Dysphagia II Art. the Histological conclusion squamous cell carcinoma moderate degree of differentiation. According to the survey, the length of the tumor in the esophagus was 5 cm, soft tissue component by x-ray 3 see as neoadjuvant chemoradiation treatment of the patient was performed radiation therapy in total ML 30 G, were carried out in parallel infusion of cytotoxic drugs: cisplatin 6 mg/m2, leucovorin (30 mg/m2bolus, fluorouracil at a dose of 300 mg/m2in a continuous infusion throughout the duration of radiation therapy (12 days). Complications nausea I degree. Through 7 days after the end of chemoradiation therapy performed control tests, which revealed a tumor resorption 80%. After 3 days the patient was performed Subtotal resection of the esophagus with simultaneous formation of the esophago-gastric anastomosis in the neck. The histological conclusion therapeutic pathomorphosis of the fourth degree. The patient was discharged in satisfactory condition home.
Thus, the inventive method can significantly reduce the toxicity of treatment and to complete all clients who am the planned treatment without interruption, allows for the treatment of patients in the original bad General status (Karnofsky index = 70%); leads to a twofold reduction of the time neoadjuvant treatment while maintaining high immediate effectiveness of therapy.
1. Shimoyama S, Aoki F, Kojima J, Kaminishi M. A case of complete response to esophageal cancer by a novel concurrent chemoradiation therapy. Hepatogastroenterology. 1999 Jul-Aug; 46(28): 2409-13.
2. Itoh Y, Fuwa N, Matsumoto A, et al. Concurrent chemoradiotherapy using a protracted infusion of low-dose CDDP and 5-FU and radiotherapy for esophageal cancer. Nippon-Igaku-Hoshasen-Gakkai-Zasshi. 1999 Jul; 59(8): 395-401.
The way neoadjuvant chemoradiation therapy in patients with cancer of the thoracic esophagus, including the introduction of cisplatin and fluorouracil, characterized in that it further administered leucovorin, the solution of fluorouracil injected hour infusion at a dose of 300 mg/m2solution of cisplatin is administered at a dose of 6 mg/m2daily once a day by intravenous drip for 1 h, and leucovorin is administered at a dose of 30 mg/m2intravenous bolus, radiation therapy performed by fractions of 3 Gy daily until the total focal dose of 30 Gy, and the dose rate of fluorouracil is 3600 mg/m2, cisplatin 72 mg/m2, leucovorin 360 mg/m2, chemotherapy and radiation therapy is started in one day.
SUBSTANCE: there is disclosed application of compound antagonist VEGF representing VEGFR1R2-FcΔCl(a) or Flt1D2. Flk1D3. FcΔCl (a) and antiproliferative agent: paclitaxel, docetaxel, or cisplatin, carboplatin, iproplatin for making a medical product for cancer treatment and/or tumour growth reduction or inhibition in an indigent person (versions), relevant method, pharmaceutical composition and a kit for cancer treatment.
EFFECT: overtotal effect of the disclosed combination (97% tumour suppression) observed without any by-effects.
10 cl, 2 dwg, 1 tbl
SUBSTANCE: invention refers to medicine, namely to oncology. General combined anaesthesia is followed with visual estimation of cancer process dissemination in organs, including with using of intraoperative ultrasonic diagnostics to localise secondary cancerous lesions. Primary cancerous lesion is extracted. The diagnosed and visible secondary cancerous lesions are extracted in any sequence. Extended limphodissection is followed by lavage with irrigating solutions within 15-20 minutes after all surgery stages. Irrigating solution is removed to install suction drains made of polymeric material, namely of silicone. Polyethylene film crucially incised in the middle is attached to wound edges with filling the operative tank with dialytic-based or Ringer-Locke solution containing ground and supplementary chemicals. Herewith perfusion solution contains Mitomycin C dosed 20 mg/m2 of body area as a ground chemical, 5-Fluorouracil dosed 1 g/m2 of body area as a supplementary chemical. Perfusion solution is introduced through the suction drains into upper operational cavity, and evacuated therefrom at temperature 42.5°C or higher through the suction drains installed in lower operational cavity. The temperature of perfusion chemical solution is controlled by thermal sensors mounted in said suction drains. Intraoperative intracavitary hyperthermal chemotherapy involves closed circulation of perfusion chemical solution within 60-120 minutes in operational cavity at rate 500-2000 ml/min combined with simultaneous mechanical agitation of the chemical solution. Intraoperative intracavitary hyperthermal chemotherapy is followed with complete closure of operational cavity and introduction of chemotherapeutical dialytic-based or Ringer-Locke solution containing 5-Fluorouracil dosed 1 g/m2 of body area and exposed in operational cavity within 8-12 hours, in the postoperative period daily 1st to 5th days after operation through the suction drains. Then the suction drains are removed. Thus prior to the operation the patient is placed on a mattress warmed up to 37-39°C on a surgical table. After extended thoracotomy, secondary cancerous lesions are localised and sised on parietal and visceral pleura with using intraoperative ultrasonic diagnostics. Pneumonectomy is carried out, while diagnosed and visible secondary cancerous lesions sised 10 mm and more including once penetrated 5 mm and deeper into invaded tissues, are extracted in any sequence. Parietal pleural areas are removed by including subtotal or total pleurectomy with thoracic lavage with irrigating solutions thereafter removed from thoracic cavity wherein suction drains made of polymeric material are installed. Polyethylene film crucially incised in the middle is attached to the edges of formed thoracic reservoir. In hyperthermal chemotherapy preparation stage, the heating mattress is disabled, while in the beginning and during hyperthermal chemotherapy, occiput and great vessel neck area are artificially cooled. Also 5% glucose solution is used as perfusion solution for hyperthermal chemotherapy. Besides the ground chemical of perfusion solution is Oxaliplatine (Eloxatine) dosed 50-130 mg/m2 of body surface area. The temperature of perfusion solution for hyperthermal chemotherapy is 43-48°C. It is introduced through the suction drains into upper thoracic cavity and evacuated through the suction drains installed in lower thoracic cavity. Intrapleural chemotherapy of the postoperative period involves introduction of chemotherapeutic solution of temperature 37-38°C through the left suction drains, combined with additional introduction of perfusion solution of 5% glucose.
EFFECT: more reliable prevention of intraoperational tumour cell penetration into vascular and lymphatic bed, prevention of malignant cell distribution and growth.
3 cl, 3 ex
SUBSTANCE: versions of the bond intended for linkage with the external domain B (ED-B) of a fibronectin are offered. The bond includes an antigen-binding fragment of one-chained antibody L19 and a cysteinum-containing linker for hanging of a radioactive label. Versions of a pharmaceutical composition for diagnostics and treatment of angiogenic diseases on the basis of the specified bond are opened. Application of bond for linkage with radioactive bond is described. The method of reception of bond in eucariotic cells is opened, including in Pichia pastoris and a set for reception is radioactive labelled agents on the basis of bond.
EFFECT: high-avid bond accumulation in solid tumours.
23 cl, 4 dwg, 5 tbl, 15 ex
SUBSTANCE: method provides interaction of cells of a medullary carcinoma of a thyroid gland with agonist SSTR2 representing bond of the formula of cyclo [Tic-Tyr-D-Trp-Lys-Abu-Phe].
EFFECT: reduction of rate of proliferation of cells of thyroid gland medullary carcinoma.
3 cl, 8 dwg, 2 tbl, 1 ex
SUBSTANCE: novel crystalline form of topotecan monohydrochloride pentahydrate is pentahydrate of 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4': 6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione monohydrochloride, as well as to preparation method, corresponding pharmaceutical compositions.
EFFECT: possibility of using claimed invention to treat anti-viral and cancer-related diseases.
23 cl, 3 dwg, 2 tbl, 3 ex
SUBSTANCE: invention concerns medicine, in particular, oncology and can be used for treatment of patients with ovarian cancer. Evacuation of an exsudate from an abdominal cavity, collection of an ascitic liquid in a sterile package is performed. Then its filtrational detoxicating is performed, removal of medium - and low-molecular ballast substances. The obtained albuminous concentrate is split for four portions, three portions are frozen, one portion is centrifugated, collecting a supernatant concentrate and entered intravenously in a perioperative period. In day of carrying out of chemotherapy one portion of an albuminous concentrate is defreezed and incubated with chemical preparations, then entered intraperitoneal. The remained two portions of an albuminous concentrate of the ascitic liquid are used for carrying out of two subsequent courses of polychemotherapy.
EFFECT: method allows to accelerate process of neogenesis at the expense of filtrational detoxicating, cryoapheresis and restores of loss of own fiber; to increase tropicity of chemical preparations to tumour tissues, centres of local and remote innidiation, the quantity and expression of by-effects decreases.
SUBSTANCE: invention concerns medicine, in particular, oncourology and can be used at treatment of a cancer of bladder. The essence of the method consists that after endoscopic oncotomy of a bladder a flexible needle is pulled in a resectoscope radiographic cone, 200 mg of Cyclophosphanum, incubated with 20 ml of plasma of the patient is injected through the submucosal layer in the basis of the removed tumour and in 6 points round it and a depot of chemical preparations is created in a zone of the removed tumour.
EFFECT: reduction of frequency of local recuring of tumours at the expense of cytotoxic action of chemical preparation by lymphogenous micrometastasises at intraparietal introduction, decrease of frequency of postoperative cystitis at the expense of chemical preparations introduction on autoplasma.
SUBSTANCE: pharmaceutical antitumoral medicinal system includes a biologically inert proto-medicine and biologically inert activation medical product. After the period of delay, which promotes differential concentrating of proto-medicines in tumoral either invasive tissues - or cells-targets, the nontoxic medical product is modified by means of an activation medical product selectively to reach toxic levels of a pharmacologically active agent in target tissues.
EFFECT: new antitumoral system possesses high efficiency and the lowered level of toxicity in comparison with already known systems.
34 cl, 5 ex
SUBSTANCE: invention concerns medicine, namely, oncology, and can be used in a complex conservative cancer treatment of an infraampullar rectum department. On the operation eve sampling of 200 ml an autoblood is made. With the method of centrifugation from blood plasma, leukomass are allocated, placing 20 ml of autoplasma and 500 mg of 5-FU in the first vial, 20 ml of autoplasma and 500 mg of 5-FU in the second vial, 20 ml of autoleukomass and 500 mg of 5-FU in the third vial, in the fourth vial - the remained components of blood and 50 mg of oxaliplatin. The vials are incubated separately during 40 minutes at 37°C. During the operation, 5 ml of autoplasma with 5-FU from the first vial are injected into the "leg" of an exophytic tumour, then its excising and introduction of the remained autoplasma with 5-FU from the first vial in mucous and a submucosal layer of an intestine round a removed tumour is made. The autoleukomass with 5-FU from the third vial is transcutaneously entered into a pararectal fat in a zone of a removed tumour. An autoplasma with 5-FU from the second vial is entered in a lymphatic vessel of the footstep. An autoblood with oxaliplatin from the fourth vial is entered intravenously-driply throughout all operation.
EFFECT: method allows reducing invalidism of patients at the expense of performance of conservative operation, to reduce amount of relapses and metastasises.
SUBSTANCE: invention concerns medicine, namely, oncology, and can be used in complex treatment of cancer of rectum. Essence of the invention consist that in the postoperative period before the beginning of radial therapy of 200 ml autoblood sampling is made, autoleukomass is allocated with the method of centrifugation from blood. Then it is placed 20 ml of the autoleukomass and 1000 mg of the 5-FU in the first vial, in the second vial - the remained formulated elements of blood and plasma, the vials with contents are incubated separately within 40 minutes at 37°C. The autoleukomass with 5-FU from the first vial is administered in intraintestinal manner into nonfunctioning intestine of the double-barrel colostomy, autoblood from the second vial is reinfused intravenously driply, then sessions of radial treatment are spent. Irradiation is made in a regimen of classical fractionating with a single dose of 2 Gy within 5 sessions in a week on primary tumour to the general dose of 40-70 Gy, the intraintestinal chemotherapy on autoleukomass with intravenous autohemotherapy is repeated once a week throughout a course of radial treatment.
EFFECT: method allows to enlarge efficiency of radial therapy, to reduce perifocal inflammation, to move patients in the resectable condition, to reduce frequency of postoperative and radial complications.
SUBSTANCE: invention refers to medicine, urology, physiotherapy and to be used in the patients suffering from chronic pyelonephritis accompanied with chronic prostatitis and chronic cystitis. The method involves taking the mineral water of the Slavjanovsky source dosed 3 - 5 ml per kg of body weight, combined with carbonic mineral baths 35-37°C for 15 minutes 3 times a day, № 8-10, mud "panties" at 40-42°C within 30 minutes to 1.5 hours, prostate massage № 8-10, additionally 50-60 minutes later followed with electropulse therapy combined with exposure to laser magnetic rays. Electropulse therapy involves low-frequency, low-voltage pulse current with a spherical unipolar electrode. Exposure is contact, labile, clockwise and located at skin projection of ascending, transverse and descending large intestine at frequency 30.2 Hz within 8-10 minutes. The course of treatment is 10-12 procedures.
EFFECT: method improves life quality of the patients both in latent phase of inflammatory process, and in mild and moderate active chronic process.
2 ex, 2 tbl
SUBSTANCE: invention concerns ophthalmology and is intended for treatment of infectious diseases of a cornea. Photodynamic therapy with the use of gel containing an octacation phthalocyanine of zinc in concentration of 1-3 mg/ml, which is applied on a cornea as a photosensitinogen, is performed. The conjunctival cavity is washed out after 30 - 40 minutes and influenced with a laser radiation with a wavelength of 675 nm with a light dose 20 - 60 J/cm2 in of 5 minutes, once a day. 1-8 sessions during each course.
EFFECT: method allows destroying the originator of keratitis in a cell with the maximum safety of surrounding tissues of the cornea.
2 tbl, 3 dwg, 1 ex
SUBSTANCE: invention concerns medicine, namely, physiotherapy, reflexotherapy. Prior to the beginning of backbone extension acupuncture by the rule "Mother-son" is performed. In 3-5 days the backbone is simultaneously influenced with a magnetic-laser radiation and extension is performed. The magnetic-laser radiation influence is spent in red 630-650 nm and infra-red 890-950 nm ranges with 50 mT intensity of a magnetic field. Backbone extension is spent in mass of a load by 15-30 kg. Total time of the procedure makes 15-20 minutes.
EFFECT: method increases analgetic effect, reduces puffiness and improves microcirculation and trophicity of tissues.
SUBSTANCE: invention relates to field of veterinary. Method includes preliminary feeding medical herb flour to cattle on the background of main diet. After feeding with medical herb flour, cattle is subjected to single low-intensity magnet-laser exposure with semi-conductor laser "Isel-Victoria" on the region of spine from withers to tail attachment from both sides. Exposure is performed for 5-10 minutes from each side, for cows from distance 10-12 cm, for calves from distance 3-4 cm from middle sagittal line. Exposure is performed with the following radiation modes: wave length 0.85-0.89 mcm, laser impulse power 3.5 mW -5.0 W, pulse repetition frequency -50-80 Hz, energy dose - 0.002-0.024 J/cm2, power density - 0.1-0.3 mW/cm2 .
EFFECT: method allows to remove heavy metals from cattle organism in short time.
SUBSTANCE: invention relates to medicine, namely to psychotherapy, reflexotherapy and concerns treating patients suffering from compulsive overeating. Psychotherapeutic influence is realised by means of individual suggestive influence. Patient is brought into the state of trance and simultaneously their acupuncture points are influenced, before individual suggestive influence, neurolinguistic programming is carried out and new ecological image of "healthy Ego" is formed. Essence transformations of personality are realised and new healthy principles of correct nutrition are formed, prevention of "diet depression" is also realised, individual suggestive influence being directed to psychological support, distraction from persistent thoughts about food, weight and figure, normalisation of food intake, elimination of diet self-restrictions, solution of life difficulties; reflexotherapeutic influence on acupuncture points is realised by infrared photobiostimulation and extremely high-frequency exposure onto corporal points, after which patient is given home task in form of "diary of correct food behavior". Infrared photobiostimulation is performed on point T20, extremely high-frequency exposure is performed on corporal points E36, MC6, GL4, VB8, VC12, RP6. Individual suggestive influence is performed by means of Ericksonian hypnosis. On finishing the course of treatment, psychological support is carried out in form of consultations in order to form and support strategy of correct food behaviour. In process of carrying out reflexotherapy course simultaneously infrared exposure of low intensity and extremely high-frequency exposure are used. Individual suggestive influence, infrared exposure of low intensity and extremely high-frequency exposure are carried out simultaneously.
EFFECT: method lies in increasing treatment efficiency.
SUBSTANCE: simultaneous joint physiotherapeutic influence repeating during several days by a magnetic field, infra-red laser radiation and radiation of light-emitting diodes on area of a postoperative wound is performed. Physiotherapeutic influence is carried out starting from the second day after operation, within 10 days, twice a day during morning and evening time, with a therapy break for the fourth day. And from the first till the third day laser radiation is influenced at frequency of repetition of impulses of 5 Hz, powers of radiation 30 mW and duration of 6 minutes. From the fifth till the tenth day laser radiation at frequency of repetition of impulses from 50 Hz to 600 Hz, power of continuous radiation is influenced of the light-emitting diodes 60 mW and duration of influence of 5 minutes.
EFFECT: acceleration of an angenesis of patients after operation, analgesic effect, absence of purulent complications, possibility to refuse a fixing thoracal corset.
FIELD: medicine; surgery.
SUBSTANCE: for treatment of keloid or hypertrophic cicatrixes of a skin unitary freeze a cicatrical tissue on a site in diameter 1 the exposition of 15-20 seconds. Thus rate of handpiece cooling makes 220°C/minute. Temperature on a working part of the handpiece makes 180°C. Then, without waiting of thawing, a laser photocoagulation in a pulsed operation is carried out. Frequency of a pulsed operation makes 10-12 Hz, power 5 W. All area of cicatrix is treated in the same way.
EFFECT: rising of efficiency of treatment, reduction of number of relapses, treatment depreciation, reduction of terms of treatment, maintenance of painlessness of procedure.
SUBSTANCE: invention concerns medicine, particularly cardiology, and can be applied in coronary disease treatment, exertional angina of I-II functional class. Magnet laser therapy is performed starting from 4th adaptation day. Infrared laser radiation is applied with wavelength of 0.89 mcm in impulse mode of intensity of 7 W, pulse frequency of 80 Hz and constant magnetic field with induction of 50 mTl. Each of 4-5 symmetrical bioactive points is affected for 1 minute. Total impact time is 8-10 minutes. Full-body hydrosulfide baths are added starting from 5th day of treatment with hydrosulfide concentration of 50-150 mg/l for exertional angina of I functional class and with hydrosulfide concentration of 50-100 mg/l for exertional angina of II functional class. Water temperature is 36°C, duration comprises 6-15 minutes. Baths are performed on days free from magnet laser therapy. A course includes 8 physiological procedures and 8 balneological procedures.
EFFECT: enhanced physical efficiency, stimulated activity of involuntary nervous system, improved indicator values of lipid exchange, peroxide lipid oxidation, antioxidant and coagulation systems, reduced risk of coronary disease complications.
2 ex, 14 tbl, 3 dwg
SUBSTANCE: correction of pain syndrome accompanying severe psoriasis is ensured with skin irradiation within affected region or above inflammatory tissue using low intensity IR rays of CO2 laser. Laser wavelength is 10.6 mcm. Radiation power density in pulse-periodic regime is 0.015-1 Wt/cm2, radiation pulse duration is 0.5-10 mc, pulse window is 10-100 mc, and highly directional IR radiation divergence is 10-2 radians. While radiation, laser beam is moved on skin within affected region during 5-10 minutes, herewith zone exposure duration determined by laser beam diameter is 1-2 sec. Skin is preliminary coated with adenosine triphosphate with daily exposure within course of 10-15 days.
EFFECT: evident reparative analgesic effect, reduced time of hospital stay, prevention of complications.
FIELD: medicine; physiotherapy.
SUBSTANCE: ultrasonic inhalations of 10 ml solution of 1% placenta hydrolyzate are applied at temperature of solution 35°C within 10 minutes. Procedure is applied in the morning on an empty stomach, or 40-60 minutes after eating. It is followed with scanning laser therapy with infra-red laser radiation from laser scanning physiotherapeutic stimulator LSPS-03.2IR. Output power at light guide end is 2 mWt, power flux density is 50 mWt/cm2. While exposure the patient is positioned lying on stomach, thus effecting paravertebral fields to the right and to the left at level D3-D9, within 3 minutes per each field. Then while the patient is positioned lying on back, liver region is exposure within 8 minutes. Course is 10 daily procedures.
EFFECT: normalised eliminative properties of epithelial barrier of a respiratory tract and local immunity of airway mucous membrane.
3 tbl, 2 ex
SUBSTANCE: invention relates to chemical-pharmaceutical industry. Set of biologically active substances "Predstar" for prevention of premature aging of human organism includes capsules of food oil "Eiconol" and vitamin-mineral complex. Application of set for prevention of premature aging of human organism and method of prevention of premature aging of organism lying in using set 1-2 times a day, capsules of food oil "Eiconol" are taken in amount 6-8 g/day 0.5-1.0 hour after meal and capsules of vitamin-mineral complex are taken in amount 1 g/day during meal during 40-60 days with course 3 times a year. "Predstar" protects organism from heart diseases, arthritises and immune diseases.
EFFECT: can be used for prevention of premature aging of organism.
3 cl, 4 tbl