Method of treating acute radioreactions in patients with larynx cancer
SUBSTANCE: invention relates to medicine, oncology, surgery, radiology, physical therapy and can be used for treating patients with larynx cancer. Area of radiation and surrounding tissues is exposed to infrared laser irradiation. From first day of radioreaction diagnostics, exposure to infrared laser irradiation with constant magnetic field with magnetic induction intensity within 20 mTa, recurrence frequency of pulse laser irradiation of infrared spectrum within 80 Hz, power 0.5-1.0 W on all zone of irradiation is performed with defocused ray for 30-120 seconds. Course includes 3-8 procedures with further application on irradiation zones and intake of a teaspoon of cedar nut oil and before going to bed daily during the whole course of radiation therapy.
EFFECT: method allows to increase efficiency of treatment of early radioreactions and prevent development of later radiation damage reducing severity and frequency of their development.
The invention relates to medicine, Oncology, surgery, physiotherapy and can be used to treat radiation reactions in patients with cancer of the larynx.
There is a method of treatment of acute radiation reactions, including pharmacotherapy . However, this method is not effective enough, because it recommends only the use of drugs, the use of which is not sufficiently effective and adequate, as it has some side effects, such as allergic reactions, in addition, it is not possible in a short period of time to completely remove radiation reaction, especially in the defeat of the skin. The main effect it aims to mucous membranes and to a lesser extent on the skin.
Closest to the present invention is a method for the treatment of radiation reaction  when radiation epithelia oropharyngeal area using a red laser radiation. The scope of it is limited, because the penetrating ability of the radiation spectrum is small (in millimeters), so the depth of the skin, its effect is not fully.
New technical problem - increasing the efficiency of the method by reducing the frequency and severity of radiation reactions, reduction of terms of treatment.
To solve the problem in the treatment of acute radiation reactions in patients with cancer of the larynx include the eating of the effect of infrared laser radiation in the irradiation region and the surrounding tissue, from the first days after diagnosis of daily radiation reaction effect of infrared laser radiation with a constant magnetic field with the intensity of the magnetic induction within 20 MT, a repetition rate of pulsed laser radiation in the infrared spectrum in the range of 80 Hz with 0.5-1.0 W across the exposure zone defocused beam within 30-120 sec, the course includes 3-8 procedures, with subsequent implementation of applications for radiation areas twice a day: immediately after treatment, combined with the ingestion of cedar oil on a teaspoon and night, every day during the entire course of radiation therapy.
In the existing literature is not found the proposed combination of distinctive features and they are not explicitly derived for the expert from the prior art. Thus, the proposed method meets the criteria of the invention of "novelty" and "inventive step. This method has been clinically tested at the Institute of Oncology in conjunction WITH Russian. Thus, the method meets the criterion of "industrial application".
The method is as follows: from the first days after diagnosis of acute radiation reactions are daily exposed to infrared laser radiation with a constant magnetic field, the intensity of the magnetic induction within 20 MT, h is depends repetition pulsed laser radiation in the infrared spectrum in the range of 80 Hz, with a capacity of 0.5-1.0 W across the exposure zone defocused beam for 30-120 seconds. The course includes 3-8 procedures depending on the type of radiation reaction, carried out daily with the subsequent implementation of applications for radiation areas twice a day: immediately after treatment, combined with the ingestion of cedar oil on a teaspoon and at night (only application), daily throughout the course of radiation therapy.
Cedar oil, sertaline handmade, manufactured by LLC "Laboratory of Ruzaeva", Tomsk, Russia THE 9141-001-58913946, has a pronounced anti-inflammatory and wound healing properties.
Patient S., 54 years old, diagnosed with Cancer of the larynx (T3N0M0), followed by radiation therapy. The patient complained of pain in the radiation zone, difficulty swallowing, pain when passing food, cough. Diagnosis: Acute radiation reaction to a dose of 44 Gy - epithelitis, dermatitis. The treatment according to the proposed method: a day in the first days after diagnosis of acute radiation reactions assigned to the influence of magneto laser using a blurred beam of infrared laser 80 Hz, 120 sec. the area of irradiation and the surrounding tissues, with the influence of a constant magnetic field of 20 MT, daily, twice a day: eposredstvenno after the procedure was performed by application of cedar oil on the irradiation zone with simultaneous ingestion teaspoon of cedar oil and at night (only application) before the end of the course of radiation therapy, leading to a radical dose within 8 days. Upon completion of the treatment course of 8 days was observed complete disappearance of pain and restored function of swallowing, stopped coughing. The phenomenon of epithelia and dermatitis were not registered.
Patient P., 58 years old, diagnosed with Cancer of the larynx (T2N0M0). In the preoperative period prescribed course of DHT. Acute radiation reaction to a dose of 20 Gy - epithelia. The patient complained of sore throat, hoarseness and pain when swallowing. The following treatment was performed in accordance with the claimed method, namely: daily was administered the magneto laser defocused beam on an area of exposure, frequency of 80 Hz for 30 seconds on the whole area of the irradiation and the surrounding tissues with the influence of a constant magnetic field of 20 MT, daily for 3 days followed by applications and the simultaneous ingestion of a teaspoon of cedar oil immediately after the procedure and at night in the form of applications throughout the course of radiation therapy, leading to a radical dose. Upon completion of the treatment of complaints and phenomena of epithelia not registered, the voice was restored.
The mode of the proposed method of treatment is chosen on the basis of data analysis of clinical observations. Treatment by the claimed method was performed in 72 patients in the Institute of Oncology in conjunction WITH the AMS. The treatment results were evaluated according to clinical and laboratory studies, as well as perform endoscopic examinations - fibroadipose.
Feature of the proposed method is the possibility of its use in the early period after diagnosis of radiation reactions with damage as mucous membranes, and skin. On the basis of clinical observations of patients with this pathology parameters of mode of exposure and dose of cedar oil selected optimal in obtaining anti-inflammatory and healing effect, aimed at creating conditions for removal of radiation damage and repair the skin and mucous membranes due to the normalization of blood circulation, especially in the area of the small blood vessels of the irradiation zone and surrounding tissues. The proposed regime contributes to shortening the healing time due to the stimulation of trophic and enhance local immunity. In addition, the conditions in preventing the development of late radiation reactions in the remote period. Infrared laser pulse mode, which is the basis of magnetic-laser therapy, avoids thermal effect due to the short pulse, which penetrates deeply into tissue (4-8 cm), which creates the possibility to influence the whole of the mucous membrane and the thickness of skin and subcutaneous clutch the key during the procedure, by changing the distance from the surface of the skin. The presence of the magnetic field and the application of cedar oil, which has anti-inflammatory and wound healing properties, in the form of applications in the area of influence of radiation therapy twice a day - right after the procedure, combined with the simultaneous ingestion and at night in the form of applications, enhance this effect, and to prevent the development of radiation fibrosis. Dose of oil - one teaspoon is optimal for healing and reduce inflammation in the affected area. Hyposensitizing these physical factors allows you to remove and prevent the development of allergic reactions. The conditions for more effective healing of the surface on which the manufactured radiation exposure, and cosmetic treatment of the skin, which leads to prevention of the formation of fibrous connective tissue and the development of late radiation reactions.
Thus, the proposed method has several advantages: reduces the frequency of side effects during radiation therapy, creating the opportunity to continue when necessary courses of radiation therapy, leading to a radical dose. The application of the method prevents the development of late radiation reactions, reduces the recovery time in patients undergoing radiation therapy and creates prob is the possibility to continue continuously required a course of radiation therapy, improving the quality of treatment and duration of life for patients.
1. Sparrows SCI Local reactions and complications (damage) in radiation therapy of malignant tumors of the head and neck. Prevention and treatment // Honey. radiology. - 1991. - N3, p.50-52.
2. Vazhenin AV, Klutina I. Laser therapy of radioepitheliitis during radiation treatment of cancer oropharyngeal area. / Laser and magnetic therapy in experimental and clinical studies. Obninsk, 1993, p.51.
A method of treating acute radiation reactions in patients with cancer of the larynx, including the effects of infrared laser radiation in the irradiation region and the surrounding tissue, characterized in that from the first day after the diagnosis, radiation reaction, daily exposed to infrared laser radiation with a constant magnetic field with the intensity of the magnetic induction within 20 MT, a repetition rate of pulsed laser radiation in the infrared spectrum in the range of 80 Hz with 0.5-1.0 W across the exposure zone defocused beam for 30-120 s, the course includes 3-8 procedures, with subsequent implementation of applications for radiation areas twice a day: immediately after treatment combined with the ingestion of cedar oil on a teaspoon and night, every day during the entire course of radiation therapy
FIELD: medicine; physiotherapy.
SUBSTANCE: 0.5% dihydroquercetine solution in amount 3 ml is introduced in lacuna cavity of palatine tonsils. Then palatine tonsil surface is exposed with distal end of flexible light guide of light-emitting diode device "АФС/К". Exposure is carried out at wavelength 0.63-0.64 mcm, maximum output power of radiation is 120 mWt. Diameter of light spot is within 3 to 5 cm. Duration of exposure is 5 minutes for each tonsil. Course of treatment is 5 sessions.
EFFECT: method provides deep penetration and fast absorption dihydroquercetine solution by surface of palatine tonsils mucous membrane due to exposure of light-emitting diode radiation of red light spectrum.
1 ex, 2 tbl
FIELD: medicine; otorhinolaryngology.
SUBSTANCE: before operation autoblood is sampled followed by thrombocyte-rich plasma clot preparation. Clot is squeezed to thickness 2-3 mm and inlaid to open wound formed after tonsil extraction.
EFFECT: method allows for reliable wound haemostasis due to faster wound regeneration affected by thrombocyte agents.
1 tbl, 1 ex
SUBSTANCE: invention is referred to medicine, namely - to otorhinolaryngology, physiotherapy. 3 ml of 0.5 % solution of dihydroquercetin administer into palatine tonsils lacunas. Then affect a surface of palatine tonsils with a distal end face of a flexible light guide of light-emitting diode apparatus "АФС/С". The wavelength is 0.45 microns; the maximum power output of radiation 120 mW, diameter of light spot from 3 to 5 cm. Duration of treatment takes 5 minutes on each tonsil. The course of treatment takes 5 sessions. The method provides deep penetration and fast absorption of a medicinal preparation with mucosa of palatine tonsils.
EFFECT: provision of deep penetration and a fast absorption of a medicinal preparation with mucosa of palatine tonsils.
1 ex, 2 tbl
SUBSTANCE: invention is referred to medicine, namely - to otorhinolaryngology, physiotherapy. 3 ml of 0.5 % solution of dihydroquercetin administer into palatine tonsils lacunas. Then affect a surface of palatine tonsils with a distal end face of a flexible light guide of light-emitting diode apparatus "АФС/ИК". The wavelength is 0.85 microns; the maximum power output of radiation 60 mW, diameter of light spot from 3 to 5 cm. Duration of treatment takes 5 minutes on each tonsil. The course of treatment takes 5 sessions. The method allows providing deeper and faster absorption of the medicinal preparation with a surface of mucosa of palatine tonsils possessing antioxidatic action, reducing inflammatory process in palatine tonsils, thus to slow down the process of peroxidation of lipids and to raise level of antioxidatic protection of tissues.
EFFECT: provision of deep penetration and fast absorption of a medicinal preparation by mucosa of palatine tonsils.
2 tbl, 1 ex
SUBSTANCE: invention is referred to medicine, namely - to otorhinolaryngology, physiotherapy. 3 ml of 0.5 % solution of dihydroquercetin administer into palatine tonsils lacunas. Then affect a surface of palatine tonsils with a distal end face of a flexible light guide of light-emitting diode apparatus "АФС/З". The wavelength is 0.53 microns; the maximum power output of radiation 60 mW, diameter of light spot from 3 to 5 cm. Duration of treatment takes 5 minutes on each tonsil. The course of treatment takes 5 sessions. The method provides deep penetration and fast absorption of a medicinal preparation with mucosa of palatine tonsils.
EFFECT: provision of deep penetration and a fast absorption of a medicinal preparation with mucosa of palatine tonsils.
1 ex, 2 tbl
FIELD: medicine; pharmacology.
SUBSTANCE: pharmaceutical formulation as solid dosage form for local treatment of mouth and pharynx inflammatory diseases, containing at least one mucus-producing medicinal plant as dry extract and at least one local analgesic taken in specified ratio. Application of pharmaceutical formulation described above for local treatment of painful inflammatory diseases of mouth cavity and pharynx.
EFFECT: composition is effective for local treatment of painful inflammatory diseases of mouth cavity and pharynx.
9 cl, 4 tbl
FIELD: medicine; otorhinolaryngology.
SUBSTANCE: application anaesthesia of posterior wall pharynx mucous membrane is performed with 10% lydocaine solution, and then 1 ml of 0.001% dalargin aqueous solution is injected in submucosa.
EFFECT: enables to reduce treatment time due to activated regeneration of pharynx mucous membrane and improved intratissual microcirculation.
2 tbl, 2 ex
FIELD: medicine; veterinary.
SUBSTANCE: antagonists of metabotropic glutamate receptor 5 (MGLUR5) are suggested to inhibit the transit relaxation of the inferior esophageal sphincter, as well as the corresponding method of treatment and/or prevention of related disorders. Particularly, such disorders include gastroesophageal reflux, gastroesophageal reflux disease, regurgitation, pulmonary disease, hypoplasia of organism, and asthma. The following antagonists of metabotropic glutamate receptor 5 are preferable: 2-methyl-6-(fenyl-etynyl) pyridine, hydrochloride 2- methyl-6-(fenyl-etynyl) pyridine, 3-[3-(5- fluoropyridine -2-il)-1,2,4-oxadiazol-5-il]-5-(metoxymethyl) benzonitrile, 3-fluor-5-[3-(5- fluoropyridine -2-il)-1,2,4- oxadiazol-5-il] benzonitrile.
EFFECT: compounds inhibited the pressure of inferior esophageal sphincter decreased by infusion pomp, in dogs.
26 cl, 4 tbl, 3 ex
FIELD: medicine, otorhinolaryngology.
SUBSTANCE: invention proposes a composition that prevents dryness in mouth and voice "breaking" and maintains tonus of vocal chords comprising the following components, weight %: (a) Piper cubeba extract, 0.5-2; (b) Glycyrrhiza glabra extract, 0.5-2; (c) Acorus calamus extract, 0.01-0.1; (d) Alpinia galanga extract, 0.01-0.1; (e) Zingiber officinale extract, 0.01-0.1, and (f) pharmaceutically acceptable additives, the balance. Method for preparing the composition involves the following steps: (a) preparing necessary parts of medicinal plants; (b) drying vegetable material from step (a) in shade; (c) milling dried vegetable material from step (b) for preparing small powder; (d) extraction of milled vegetable material from step (c) with aqueous-alcoholic solution at temperature 25-350C for 4-7 days for preparing aqueous-alcoholic extract; (e) concentrating the extract from step (d) under reduced pressure and temperature 40-600C for preparing the concentrated extract; (f) lyophilization of the concentrated extract from step (e) for complete removal of solvent residue and preparing the necessary vegetable extract, and (g) addition of vegetable extract from step (f) to prescription in common with suitable pharmaceutically acceptable additives for preparing the necessary composition. The composition is used in bronchitis and allergic throat diseases. Invention provides realization of indicated designations.
EFFECT: valuable medicinal properties of composition.
35 cl, 2 tbl, 5 ex
SUBSTANCE: endoscopy-controlled tissue of adenoid vegetation is pretreated with 0.01% miramistin solution, after which 8-10 mL of 0.1% levamisol are introduced into adenoid crypts.
EFFECT: enhanced treatment efficiency due to optimal amounts and concentrations of drugs as well as methods for administration thereof.
SUBSTANCE: invention relates to field of medicine, namely to ophthalmology. Laser stroboscopy is carried out during 5 days, 2 times a day with 1 hour interval. First 10 minutes each eye is influenced in turn, then for 5 minutes both eyes are influenced simultaneously. Distance to speckle is 1 m.
EFFECT: recovering binocular functions with elimination of anisoaccomodation, enhancing binocular interaction, increasing visual acuity.
3 cl, 2 ex
SUBSTANCE: invention refers to medicine and aims at epilepsy management. Carotid and vertebral arteries are sequentially exposed to IR laser light, infra-red laser radiation to the right and to the left each for 5 minutes. Frontal, temporal, parietal and occipital lobes are exposed to magnetic field and microwave radiation to the right and to the left each for 3 minutes. And visual analyser is exposed to IR waves within 30 minutes. It is combined with electroencephalographic training with course of treatment 15 procedures.
EFFECT: disclosed method allows for improved mental measurements, relieved remove proneness to convulsive activity, suppressed epileptogenic zones, improved metabolic and energy cerebral processes, normalised cerebral blood flow regulation, recovered cortical neurodynamic disorders.
SUBSTANCE: invention refers to medicine, oncology and to be used for neoadjuvant chemoradiotherapy in the patients suffering from thoracic oesophagus cancer. Said therapy is ensured by introduction of cisplatin and leucovorin, and continuous intravenous infusions of fluorouracil dosed 300 mg/m2. Cisplatin solution is introduced intravenously drop-by-drop and dosed 6 mg/m2 daily once a day within 1 hour. Leucovorin is injected intravenously jet-like and dosed 30 mg/m2. Radiotherapy involves daily fractions 3 Gy to total basic dose 30 Gy. The course dose of fluorouracil is 3600 mg/m2, of cisplatin is 72 mg/m2, of leucovorin 360 mg/m2. Chemotherapy and radiotherapy are to be started the same day.
EFFECT: disclosed method allows for considerably reduced toxicity of treatment to be continuous, treatment of the patients originally of bad performance status, for doubly reduced time of neoadjuvant treatment with maintaining high clinical effectiveness.
SUBSTANCE: invention refers to medicine, urology, physiotherapy and to be used in the patients suffering from chronic pyelonephritis accompanied with chronic prostatitis and chronic cystitis. The method involves taking the mineral water of the Slavjanovsky source dosed 3 - 5 ml per kg of body weight, combined with carbonic mineral baths 35-37°C for 15 minutes 3 times a day, № 8-10, mud "panties" at 40-42°C within 30 minutes to 1.5 hours, prostate massage № 8-10, additionally 50-60 minutes later followed with electropulse therapy combined with exposure to laser magnetic rays. Electropulse therapy involves low-frequency, low-voltage pulse current with a spherical unipolar electrode. Exposure is contact, labile, clockwise and located at skin projection of ascending, transverse and descending large intestine at frequency 30.2 Hz within 8-10 minutes. The course of treatment is 10-12 procedures.
EFFECT: method improves life quality of the patients both in latent phase of inflammatory process, and in mild and moderate active chronic process.
2 ex, 2 tbl
SUBSTANCE: invention concerns ophthalmology and is intended for treatment of infectious diseases of a cornea. Photodynamic therapy with the use of gel containing an octacation phthalocyanine of zinc in concentration of 1-3 mg/ml, which is applied on a cornea as a photosensitinogen, is performed. The conjunctival cavity is washed out after 30 - 40 minutes and influenced with a laser radiation with a wavelength of 675 nm with a light dose 20 - 60 J/cm2 in of 5 minutes, once a day. 1-8 sessions during each course.
EFFECT: method allows destroying the originator of keratitis in a cell with the maximum safety of surrounding tissues of the cornea.
2 tbl, 3 dwg, 1 ex
SUBSTANCE: invention concerns medicine, namely, physiotherapy, reflexotherapy. Prior to the beginning of backbone extension acupuncture by the rule "Mother-son" is performed. In 3-5 days the backbone is simultaneously influenced with a magnetic-laser radiation and extension is performed. The magnetic-laser radiation influence is spent in red 630-650 nm and infra-red 890-950 nm ranges with 50 mT intensity of a magnetic field. Backbone extension is spent in mass of a load by 15-30 kg. Total time of the procedure makes 15-20 minutes.
EFFECT: method increases analgetic effect, reduces puffiness and improves microcirculation and trophicity of tissues.
SUBSTANCE: invention relates to field of veterinary. Method includes preliminary feeding medical herb flour to cattle on the background of main diet. After feeding with medical herb flour, cattle is subjected to single low-intensity magnet-laser exposure with semi-conductor laser "Isel-Victoria" on the region of spine from withers to tail attachment from both sides. Exposure is performed for 5-10 minutes from each side, for cows from distance 10-12 cm, for calves from distance 3-4 cm from middle sagittal line. Exposure is performed with the following radiation modes: wave length 0.85-0.89 mcm, laser impulse power 3.5 mW -5.0 W, pulse repetition frequency -50-80 Hz, energy dose - 0.002-0.024 J/cm2, power density - 0.1-0.3 mW/cm2 .
EFFECT: method allows to remove heavy metals from cattle organism in short time.
SUBSTANCE: invention relates to medicine, namely to psychotherapy, reflexotherapy and concerns treating patients suffering from compulsive overeating. Psychotherapeutic influence is realised by means of individual suggestive influence. Patient is brought into the state of trance and simultaneously their acupuncture points are influenced, before individual suggestive influence, neurolinguistic programming is carried out and new ecological image of "healthy Ego" is formed. Essence transformations of personality are realised and new healthy principles of correct nutrition are formed, prevention of "diet depression" is also realised, individual suggestive influence being directed to psychological support, distraction from persistent thoughts about food, weight and figure, normalisation of food intake, elimination of diet self-restrictions, solution of life difficulties; reflexotherapeutic influence on acupuncture points is realised by infrared photobiostimulation and extremely high-frequency exposure onto corporal points, after which patient is given home task in form of "diary of correct food behavior". Infrared photobiostimulation is performed on point T20, extremely high-frequency exposure is performed on corporal points E36, MC6, GL4, VB8, VC12, RP6. Individual suggestive influence is performed by means of Ericksonian hypnosis. On finishing the course of treatment, psychological support is carried out in form of consultations in order to form and support strategy of correct food behaviour. In process of carrying out reflexotherapy course simultaneously infrared exposure of low intensity and extremely high-frequency exposure are used. Individual suggestive influence, infrared exposure of low intensity and extremely high-frequency exposure are carried out simultaneously.
EFFECT: method lies in increasing treatment efficiency.
SUBSTANCE: simultaneous joint physiotherapeutic influence repeating during several days by a magnetic field, infra-red laser radiation and radiation of light-emitting diodes on area of a postoperative wound is performed. Physiotherapeutic influence is carried out starting from the second day after operation, within 10 days, twice a day during morning and evening time, with a therapy break for the fourth day. And from the first till the third day laser radiation is influenced at frequency of repetition of impulses of 5 Hz, powers of radiation 30 mW and duration of 6 minutes. From the fifth till the tenth day laser radiation at frequency of repetition of impulses from 50 Hz to 600 Hz, power of continuous radiation is influenced of the light-emitting diodes 60 mW and duration of influence of 5 minutes.
EFFECT: acceleration of an angenesis of patients after operation, analgesic effect, absence of purulent complications, possibility to refuse a fixing thoracal corset.
FIELD: medicine; surgery.
SUBSTANCE: for treatment of keloid or hypertrophic cicatrixes of a skin unitary freeze a cicatrical tissue on a site in diameter 1 the exposition of 15-20 seconds. Thus rate of handpiece cooling makes 220°C/minute. Temperature on a working part of the handpiece makes 180°C. Then, without waiting of thawing, a laser photocoagulation in a pulsed operation is carried out. Frequency of a pulsed operation makes 10-12 Hz, power 5 W. All area of cicatrix is treated in the same way.
EFFECT: rising of efficiency of treatment, reduction of number of relapses, treatment depreciation, reduction of terms of treatment, maintenance of painlessness of procedure.
SUBSTANCE: claimed invention relates to chemical-pharmaceutical industry and concerns auxiliary binding substances for manufacturing drop-shaped tablets and to preparation of drop-shaped tablets. Auxiliary binding substances according to claimed invention are selected from group which consists of monosaccharide, oligosaccharide, polysaccharide, sugar ester, sugar of alcohol structure, alpha-hydroxy acid, higher fatty acid derivative, higher aliphatic alcohol, polyol, urea and poly(ethyleneoxide) derivative.
EFFECT: claimed invention reduces toxicity caused by polyethylene glycol, improves drop-shaped tablet quality and accelerates development of drop-shaped tablets.
20 cl, 68 ex, 2 tbl