Method for selecting trained workers maintaining railroad tunnel into risk group of incipient signs of health situations

Technique involves a blood serum examination for thyrotropic hormone, mcUnit/ml, free T4, pmole/l, prolactine, mIU/ml, follicle-stimulating hormone, mIU/ml, lutenizing hormone, mIU/ml, testosterone, nmole/l, dehydroepiandrosterone sulphate, mcg/ml, cortisol, nmole/l, oestradiol, pg/ml, 17-OH progesterone, nmole/l. Calculating an integral hormone state (HIS) by formula follows. If the HIS value is below 0.799, a habitual disorder is stated, which is accompanied by a minimum risk of the reproductive disorders. The HIS values falling from the range of 0.800 to 1.000 provides stating the tensed hormonal regulation reflecting a moderate risk of the reproductive disorders. The disturbed interhormonal cooperation corresponds to the HIS value falling within the range of 1.001 to ≤1.210 that represents a high risk of the reproductive disorders. The HIS value of more than 1.211 shows the lack of reserves that testifies to a very high risk of the reproductive disorders.

For immature girls after day 3-5 of menstrual cycle a level of Anti-Mullerian Hormone is determined in blood serum by method of enzyme multiplied immunoassay (ELISA), and if its value exceeds 5.2 ng/ml the menstrual dysfunction is diagnosed against the background of polycystic ovarian syndrome.

Method involves detecting a threatening miscarriage and a carrier state of the polymorphism in the gene of folate metabolism, as well as a CD54⁺ lymphocyte ratio, lactoferrin and β-subunit of human chorionic gonadotropin (β-HCG) levels in venous blood of a pregnant woman from the onset of pregnancy to the end of the first trimester. That is followed by calculating a prognostic index (PI) by formula: PI=0.7199X₁+1.2552X₂-0.00653X₃-0.0009X₄+0.0722X₅+1.1277, wherein X₁ is the threatening miscarriage, yes/no (1/0); X₂ is the polymorphism in the gene of folate metabolism, yes/no (1/0); X₃ is the CD54⁺ lymphocyte ratio, %; X₄ is the lactoferrin level, ng/ml; X₅ is the concentration of the free β-subunit of human chorionic gonadotropin (β-HCG), ng/ml. If PI<0, the gestational complications are predicted, while PI>0 enables stating a low risk of pathological conditions accompanying pregnancy. A sensitivity of the presented method makes 81.2%, its specificity is 85.1%. The method effectiveness is 83.2%.

Invention refers to medicine. Substance of the early diagnostic technique for chronic renal disease consists in using a dosage range of dopamine of 1 to 3 mcg/kg of body weight and a standard water load of 200 ml. No glomerular filtration rate increase testifies to the presence of early signs of chronic renal disease.

First stage comprises a night suppressive test with dexamethasone 1 mg with a test considered to be positive, if plasma cortisol measured at 8.00 in the next morning exceeds 50 nmole/l. If the first stage has a positive result, the second stage is performed 1-2 days later. At the second stage, blood plasma cortisol at 24.00, daily urine free cortisol, a coefficient of circadian rhythm of cortisol secretion are determined on the same day. If at least two of the three test results are above normal: plasma cortisol at 24.00 is more than 207 nmole/l, daily urine free cortisol is more than 180 mcg/day, coefficient of circadian rhythm of cortisol secretion is more than 50%, hypercorticoidism syndrome is diagnosed. The presented technique provides higher accuracy and simplifies diagnosing of the given disease.

Invention relates to the field of immunology, namely to enzyme-immunoassay, in particular to a method of detecting forms of vascular endothelial growth factor (VEGF) with a size more than 110 amino acids in a biological sample. The method includes the following stages: contact and incubation of the biological sample with an uptake reagent, immobilised on a solid substrate, where the uptake reagent contains a monoclonal antibody, which recognises and specifically binds with residues, in quantity more than 110, from human VEGF; separation of the biological sample from the immobilised uptake reagents; contact of the immobilised molecular complex of the reagent of the uptake-target with detected antibody, which binds with VEGF domains, responsible for binding with KDR and/or FLT1 receptor, or which binds with an epitope in VEGF_1-110; measurement of the level of VEGF₁₁₀₊, bound with reagents of the uptake, with application of means of detection for the detected antibody. Set of immune assay reagents for detection of VEGF₁₁₀₊ forms in the biological sample. An antibody 5C3, obtained from hybridoma 5C3.1.1 with a depositary number PTA-7737, with the said antibody 5C3 binding VEGF₁₁₀₊ forms, including VEGF₁₂₁₊. Hybridoma 5C3.1.1, deposited in ATCC with the depositary number PTA-7737, to obtain the monoclonal antibody 5C3.

Blood is examined. The steroid hormones cortisol (nmole/l) and DHEA-S (mcmole/l), as well as the oxidative stress values - oxidative modified proteins (OMP, nM/mg, protein), malondialdehyde (MDA, nM/ml) and SH groups mg% are evaluated. The forced expiratory volume 1(%) FEV1 is calculated by formula on the basis of the derived values. If the derived FEV1 is within 50% to 80%, the presence of a moderate degree of chronic obstructive pulmonary disease; the FEV1 being within the range of 30 to 49% means a severe degree of chronic obstructive pulmonary disease (COPD), and the derived value being less than 30% shows an extremely severe degree of COPD.

Blood serum of the younger patient suffering chronic prostatitis is examined for total testosterone, sex hormone-binding globulin to calculate a free testosterone index; high-density lipoproteins and triacylglycerides are determined, and an atherogenic index is calculated by formula. If the atherogenic index is <3.7, a high risk of the early development of atherosclerosis is predicted.

What is involves is the histological examination of tissue fragments taken from the extracted lung with primary, intermediate and segmental bronchi at 4-5 cm from the tumour, and disregeneration change cases are determined in the respiratory bronchial epithelium, including: basal cell hyperplasia (BCH), squamous metaplasia (SM) and if observing a combination of basal cell hyperplasia and squamous metaplasia (BCH+SM+) in the respiratory bronchial epithelium adjacent to the tumour, a risk of developing the recurrent non-small-cell lung cancer is predicted.

Method for prediction of recurrent cervical cancer involves biochemical daily urine analysis to determine daily urine androsterone and etiocholanolone to be related; if the relation is 0.75 mg/day or less, the recurrent disease is predicted for the first 2 years, and if the relation exceeding 0.75 mg/day, a prolonged recurrence-free period up to 10 years or more is predicted.

Evaluation of the affection of main arteries of the lower extremities in points is performed. Then the outflow channel consistency coefficient (OCCC) is calculated on the basis of the obtained data by an original mathematical formula, and if OCCC coefficient is 0.8±0.18 the expected duration of the shunt patency constitutes 0.68±0.1 year, if the coefficient is 1.22±0.05 - 2.33±0.58 year, if it is 1.28±0.13 - 3.80±1.30 year, if it is 1.65±0.25 - over 5 years.

Invention refers to diagnostic visualisation tools. A nidus detection system comprises a segmentation unit of an anatomical first presented image of the region, a detection unit of high tracer accumulation according to the functional second presented image, a classification unit of high tracer accumulation in accordance with a position with regard to the anatomical structures, an accumulation detection unit, which analyses the segmented regions to identify normal and abnormal regions, an attenuation unit of high tracer accumulation on the functional second presented image on the basis of the results obtained by the classification unit, the above attenuated regions correspond to the anatomical structures, which are identified as normal; there are also provided an identification unit of the high accumulation as one of the potential pathological change, and a regulation unit configured to compare metabolic activity of the non-attenuated high-intensity regions to metabolic activity of the regions identified by the accumulation detection unit as normal. A diagnostic visualisation system for implementing a method for diagnostic visualisation comprises an anatomical image scanner, a visualisation scanner by positron tomography and said nidus detection system.

In the method, computed tomography is carried out with a scanning step of not more than 2.5 mm, analysis of the bitmap image of a structural component is carried out using a viewing program which realises a RGB colour model; the method includes assigning a coordinate system and boundaries of the analysis region, obtaining a digital matrix of colour indices of the pixels of the analysis region, determining the outline of the section of the structural component, determining the average value of the colour index of pixels of sections of the structural component; the distribution of modulus of elasticity values in the sections of the structural components is judged from the values of the elements of the digital matrix generated by the viewing program during analysis.

Invention relates to a projection value processing device for processing collected projection values. A first image is reconstructed by a reconstruction unit based on the investigated collected projection data with reconstruction allowance. A simulated projection value determining unit determines simulated projection values by simulating projection through the investigated reconstructed first image with reconstruction allowance, and difference values for the collected projection values are determined by a difference determining unit, where a difference value indicates the degree of difference between corresponding collected projection values and the reconstruction allowance, by comparing the collected projection values and the corresponding simulated projection values.

X-ray examination of a venous bed of an individual's rectum involves using 76% urografin. The inferior mesenteric vein stem and iliac vascular bundles from both sides are approached. They are catheterised and prepared by washing in 10% ammonia and distilled water. Before preparation, the inferior mesenteric vein is detected by a method of visualisation of the portal vein system. A green solution of brilliant green is inserted into its stem. The final stage is a direct X-contrast examination by fixed 12P9 Armobil-9 X-ray apparatus. 3 series of images are done. The first comparison X-ray represents plan radiography in a frontal projection of the small pelvis. The second X-ray is plan radiography in a frontal projection of the small pelvis with tight filling of the prepared bed of the rectal portal system with X-ray contrast 76% urografin. The third X-ray is plan radiography in a frontal projection of the small pelvis with tight filling of the internal iliac veins from both sides in a combination with X-ray contrast 76% urografin.

Invention can be used for the purpose of diagnosing thromboembolia of pulmonary artery (TEPA). An X-ray imaging of the thoracic organs is performed according to a standard treatment regimen if observing the clinical signs of TEPA in the patient; that is followed by a postprocessing treatment of the formed imaging by assessing total haziness intensity of an analysed area matched with a projection of a pulmonary segment. That is compared to a shadow intensity of a descending branch of the pulmonary artery from the right. If the analysed areas having the haziness intensity of less than 10% of the shadow intensity of the descending branch of the pulmonary artery are detected among the similar ones, thromboembolia of pulmonary artery is diagnosed.

Invention refers to medicine, oncology, radiodiagnostics of nonpalpable intraductal benign tumours and intraductal breast cancer manifested by nipple discharge and not presented by mammography and ultrasonic examination. The method involves a stereotaxic percutaneous invasive tumour labelling; that is ensured by enhancing the tumour first by filling the ductal system with an urographin solution; a ductograpm is derived in a frontal projection, and mutually perpendicular lines are drawn thereon - through a tumour centre in the frontal projection and through a nipple in a sagittal plane. That is followed by measuring lengths of two segments: from the nipple to a cross point of these lines and from a lateral or medial edge of the gland depending on the tumour localisation in an inner or outer quadrant, to the tumour. The drawn segments are marked on the skin by protracting the corresponding distance from the nipple and from the edge of the gland to the cross point thereof that is a point of the tumour projection on the skin. This marked point is used for the purpose of the stereotaxic localisation of the tumour by means of a wire localisation mandril.

Invention refers to medicine, namely to cardiovascular surgery and interventional arrhythmology. The preoperative stage involves an angiography with a catheter delivered through a femoral vein into a right ventricular outflow tract to reach a pulmonary valve; the examination covers an anteroposterior projection with contrasting until the right ventricle, tricuspid valve ring, pulmonary artery, pulmonary veins, left atrium, left ventricle and ascending aorta and aortic arch are visualised.

11C-methionine 350 MBq/m² is additionally administered intravenously into the patient with ¹⁸F-FDG-negative tumour at least 18 hours after ¹⁸F-FDG injection; 10-15 min later, positron emission tomographic scanning of the thoracic organ follows. Either before the emission tomographic scanning with ¹⁸F-FDG, ¹¹C-methionine 350 MBq/m² is administered intravenously into the patient, and 10-15 min later, the PET scanning is performed. The intravenous administration of ¹⁸F-FDG for the PET procedure is performed at least 3 months after the ¹¹C-methionine injection, while the PET scanning with ¹⁸F-FDG is performed at least 120 min after administered in a dose of 110 MBq/m². Typical lung carcinoid is diagnosed by the ¹¹C-methionine accumulation in the tumour and the absence of the ¹⁸F-FDG accumulation therein.

Invention relates to electrical engineering and to power supply systems. Visualisation (100) system includes stationary gantry (102) and turning gantry (104). Turning gantry (104) includes the first component (110, 114, 116), to which the first power is fed, and the second component, to which the second power is fed. The first power and the second power differ from each other. Non-contact power circuit (118) includes the first transformer (202, 204, 306) for feeding of the first power from stationary gantry (102) to turning gantry (104), as well as the second transformer (202, 204, 306) for feeding of the second power from stationary gantry (102) to turning gantry (104). The first and the second transformers (202, 204, 306) are shifted relative to each other along longitudinal axis (108) to the specified final non-zero distance (240). According to another version of implementation, visualisation system (100) includes stationary gantry (102) and turning gantry (104) rotating about longitudinal axis (108). Non-contact power circuit (118) supplies the power from stationary gantry (102) to turning gantry (104). Windings (214, 218, 230, 234) of non-contact power circuit (118) are installed on carrier (700) made on a non-polymer base.

Method involves synchronous recording of vibrational displacement and dynamic force of a sound wave emitted from a whistle source at its peak frequency in at least four points of the chest surface by means of an acoustic sensor, a position of which in space and in a relation of the individual's chest is unknown. An acoustic intensity is determined at the peak whistle frequency; real Re(W) and imaginary Im(W) parts of the acoustic intensity are related (C); a distance (r) from each specified point of the chest to the whistle source is determined taking into account an emitter type (a monopole, a dipole or a quadrupole). A location and a spread of locations of the whistle source are determined for each of three emission types separately with the use of differential distance methods; the whistle source is typed so as to have the least location spread, whereas its location is presented in the form of point or interval point in the three-dimensional space.