Cross-linked hyaluronic acid and production method thereof. RU patent 2456299.

FIELD: chemistry.

SUBSTANCE: method involves activation of hyaluronic acid using a cross-linking agent and an auxiliary cross-linking agent. The activated hyaluronic acid then reacts with a nucleophilic cross-linking agent. The pH of the reaction medium ranges from 8 to 12. The nucleophilic cross-linking agent contains at least 50 wt % oligopeptide or polypeptide. Further, pH of the reaction medium is regulated to 5-7 and cross-linked hyaluronic acid is precipitated in the organic solvent. The invention also relates to use of the cross-linked hyaluronic acid obtained using this method in plastic surgery to make implants and to a hedrogel containing said cross-linked hyaluronic acid in a buffer aqueous solvent.

EFFECT: invention enables to obtain cross-linked hyaluronic acid in dry form, having high resistance to decomposition factors such as temperature, free radicals and enzymes.

18 cl, 3 tbl, 3 ex

IPC classes for russian patent Cross-linked hyaluronic acid and production method thereof. RU patent 2456299. (RU 2456299):

C08B37/08 - Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

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