Method for chitosane production |
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IPC classes for russian patent Method for chitosane production (RU 2250909):
Method for producing of chitosan from chitin of cancerous / 2246880
Method involves providing deacetylation of raw material with the use of preliminarily cooled alkaline solution; washing and drying. Deacetylation process is performed in three stages, first stage being performed for 7 days and subsequent two stages being performed for 2 hours each, combined with thermal processing at temperature of 55-590C. Washing process is provided after each deacetylation stage.
 Macroporous chitosan granules and method of production thereof, a method of culturing cells / 2234514
The invention relates to macroporous chitosan granules having a relatively large and uniform pore size of 30-150 μm inside and outside, which are distributed from the surface to the area of the nucleus, and the way they are received, which includes the following stages: adding dropwise chitosan solution, the aqueous chitosan solution, or a mixture thereof in the low-temperature organic solvent or liquid nitrogen; regulation of pore size using the method of phase separation due to temperature differences
The method of obtaining innovating derivatives of chitosan oligosaccharide / 2232775
The invention relates to a method for producing derivatives of chitosan oligosaccharide and can be used in medical and food industries, as components of various compositions
 Method cross-linkage carboxylating polysaccharides / 2230073
The invention relates to a method of cross stitching carboxylating polysaccharides and can be used in medical and pharmaceutical fields, and in cosmetology
A method of obtaining modified chitosan emulsions and products on its basis / 2223279
The invention relates to chemical technology, particularly to a method for producing a gel or suspension of chitosan, and can be used in food, cosmetic, pharmaceutical and other industries
A method of producing chitosan / 2221811
The invention relates to a method of producing chitosan, which can be used as a sorbent, emulsifier, foaming agent
 The method of obtaining food biosorbent / 2219997
The invention relates to the microbiological industry, and specifically to methods for biosorbent by microbiological synthesis, which can be used as activator beer fermentation
 The way waste complex processing of chitin-containing raw material / 2207033
The invention relates to a method for integrated processing of chitin-containing raw materials with the aim of obtaining chitin/chitosan and enzymatic protein hydrolysates for use as the basis of microbiological culture media
 Photoallergen gel based on crosslinked hyaluronic acid and method thereof / 2197501
The invention relates to biocompatible fototienda gel based on crosslinked hyaluronic acid, which has specific physical properties, the methods of its production and its applications as biomedical materials
Method for producing of chitosan from chitin of cancerous / 2246880
Method involves providing deacetylation of raw material with the use of preliminarily cooled alkaline solution; washing and drying. Deacetylation process is performed in three stages, first stage being performed for 7 days and subsequent two stages being performed for 2 hours each, combined with thermal processing at temperature of 55-590C. Washing process is provided after each deacetylation stage.
Method for chitosane production / 2250909
Claimed method includes subsequent chitosane-containing raw material with non-polar liquefied gas, water, alkali, water, acid, water, alkali, and water to produce target product in form of solid residue, wherein in at least first extraction step pressure in reaction mixture is periodically released to provide extractant boiling, and than increased up to starting value.
 Method for preparing water-soluble derivatives of chitosan / 2263681
Invention describes a method for preparing water-soluble derivatives of chitosan. Method involves treatment of chitosan with acid medium up to its swelling wherein vapor medium water-acid is used as acid medium. Treatment of chitosan is carried out with vapor of monobasic acid aqueous solution taken among the group including hydrochloric acid, formic acid and acetic acid. Method allows simplifying technology in preparing water-soluble derivatives of chitosan.
Method for preparing chitosan polyethylene glycol ester / 2266915
Invention relates to methods for preparing chitosan esters. Invention describes a method for preparing chitosan polyethylene glycol ester that involves dissolving chitosan in acetic acid followed by alkalization. Then the reaction mixture is subjected for effect of ethylene oxide under pressure 1-3 atm and temperature 60-100°C, and the concentration of reaction mass is corrected by addition of distilled water up to the density value of solution 1.030-1.032 g/cm3. Then the reaction mass is purified by electrodialysis at the rate value of solution in treatment chambers 3.0 cm/s, not less, temperature 20-45°C, the current density value 0.25-0.75 A/dm2 and the constant volume of the reaction mass. Method provides enhancing the effectiveness of purification by electrodialysis due to reducing energy consumptions. Chitosan esters can be used in medicine, cosmetics, food and chemical industry.
 Modified chitosan / 2269542
Invention relates to the group of chitosan-containing compounds. Invention relates to synthesis of modified chitosan of the following structure:
 Chitosan preparation process / 2277543
Chitosan preparation process comprises breaking naturally occurring chitin-containing material, charging it into reactor, demineralization with 6-7% aqueous hydrochloric acid, deproteination with sodium hydroxide solution at 85-95°C, deacetylation with sodium hydroxide solution on heating, decoloration, and washing with water after each stage to pH 6.5. Process is characterized by that chitin-containing material broken to achieve fraction 0.5-6 mm is fed simultaneously into a number of reactors, wherein demineralization is effected with aqueous hydrochloric acid stream at 85-95°C for 1.5 h while controlling pH in each reactor exit to achieve acid concentration in each reactor exit the same as concentration of the initial acid by way of feeding it in a continuous manner. In addition, deproteination is carried out with 6-7% sodium hydroxide solution stream for 1.5 h followed by discharging treated material into autoclave to perform deacetylation simultaneously with decoloration using 50% sodium hydroxide solution at 130-140°C in inert gas environment and in presence of 3-5% hydrogen peroxide solution used in amount 3-5% of the total volume of mixture.
 Method for preparing water-soluble saline complexes of hyaluronic acid (variants) / 2280041
Invention relates to methods for preparing water-soluble saline complexes (associates) of hyaluronic acid with d-metals of IV, V and VI periods of Mendeleyev's periodic system of elements that can be used in pharmacology and cosmetology. Invention describes a method for preparing water-soluble saline complexes of hyaluronic acid involving preparing an aqueous solution of salt of d-metal of IV, V and VI periods of periodic system and its mixing with hyaluronic acid sodium salt, holding the mixture, its stirring, dilution with water and isolation of the end product. For mixing method involves using the amount of aqueous salt of abovementioned d-metal that is equivalent to the amount of carboxy-groups of hyaluronic acid sodium salt or in the limit from 0.95 to 1.10. After dilution with water the solution mixture is subjected for ultrafiltration on separating membranes with simultaneous washing out with aqueous salt solution of abovementioned d-metal firstly and then with deionized water followed by concentrating the product. By another variant for mixing the method involves the amount of aqueous solution of d-metal salt lesser of the equivalent amount of carboxy-groups in hyaluronic acid sodium salt. After dilution with water the mixture is subjected for ultrafiltration on separating membranes with simultaneous washing out with deionized water followed by concentrating the product also. Method is characterized by the decreased time of processes and simplicity.
Method for production of ionically bound depolymerized chitosane derivatives / 2281292
Claimed method is based on using of chitosanase in acetic acid medium and spray drying of and depolymerized chitosane and is characterized in that obtained depolymerized chitosane is preliminary converted in non-ionized form by neutralizing of bound acetic acid with ammonium hydroxide followed by precipitation in ethanol and air drying. Further interaction is carried out with ammonium lipoate or glutathione in aqueous medium. Claimed products may be used individually or in combination with other components.
 Method for preparing modified glycosaminoglycans possessing analgesic property / 2283320
Invention relates to a method for preparing modified glycosaminoglycans possessing analgesic properties. Method involves interaction of glycosaminoglycans with 1-phenyl-2,3-dimethyl-4-aminopyrazolone-5-(4-aminoantipyrine) in aqueous medium at pH = 4.7-4.8 in the presence water-soluble 1-ethyl-3-[3-(dimethlamino)propyl]carbodiimide as a condensing agent at room temperature followed by purification from low-molecular reagents. Method involves a single step that simplifies technology in preparing modified glycosaminoglycans.
 Method for isolating purified chitosan from reaction mixture (variant) / 2286352
Invention relates to a method for preparing chitosan and purification from components of the reaction mixture - low-molecular products of deacetylation and alkali excess. Invention relates to a method for purifying chitosan prepared by solid-state method involving treatment of reaction mass with extractant consisting of 3.3-20.0% of water, 32.2-57.1% of ethyl acetate and 24.6-64.5% of ethanol at the extractant boiling point. Also, invention relates to a method for purifying chitosan prepared by suspension method and involving treatment of the reaction mass with ethyl acetate and the following treatment with extractant consisting of 6.2-25.0% of water, 12.5-62.5% of ethyl acetate and 31.3-62.5% of ethanol at the extractant boiling point.
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FIELD: organic chemistry. SUBSTANCE: claimed method includes subsequent chitosane-containing raw material with non-polar liquefied gas, water, alkali, water, acid, water, alkali, and water to produce target product in form of solid residue, wherein in at least first extraction step pressure in reaction mixture is periodically released to provide extractant boiling, and than increased up to starting value. EFFECT: method with reduced energy consumption.
The invention relates to technology chitosan production. A method of producing chitosan, which provides the consistent extraction of chitin-containing raw material nonpolar liquefied gas in the field of ultrasonic vibrations at a constant pressure above atmospheric, which is discharged to atmosphere after the completion of this phase extraction, water, alkali, obtained by dispersion in water, liquid ammonia, water, acid, water, alkali and water to obtain the desired product as a solid residue (EN 2116314 C1, 27.07.1998). The disadvantage of this method is the high energy intensity. The technical result of the invention is to reduce energy consumption. This result is achieved in that in the method of production of chitosan, which provides the consistent extraction of chitin-containing raw material nonpolar liquefied gas, water, alkali, water, acid, water, alkali and water to obtain the desired product as a solid residue, according to the invention at least in the first stage of extraction pressure in the extraction mixture is periodically reset to the value that provides the lash of the extractant, and increase to its original value. The method is implemented as follows, Chitinous biological raw materials, for example the EP crustacean shells, sequentially extracted first nonpolar liquefied gas by well-known methods (Kasyanov GI and other Processing of plant raw material liquefied and compressed gases. - M.: Agroniiteipp, 1993 - 40 C.)and then with water, alkali, water, acid, water, alkali and water by well-known methods (EN 2000066 WITH, 07.09.1993) to obtain the target product as a solid residue. At least at first, and preferably at each stage of extraction pressure in the extraction mixture is periodically reset to the value that provides the lash of the extractant, and increase to its original value. Initial pressure at each stage of extraction corresponds to the vapor pressure of the solvent at the temperature of the extraction mixture. The initial temperature of the extraction mixture corresponds recommended for each stage of the extraction according to the above sources of information. The frequency and quantity of discharge pressure is determined for each stage of extraction by well-known methods (Lomachinskiy VA high technology processing of vegetable raw materials. - M.: Russian technology, 1996, p.54-56). Education each bubble of gas phase in the extraction mixture is accompanied by the creation of a shock wave that destroys the cellular structure of biological materials. As is known, the action of the shock wave slabeva is proportional to the square of the distance from the epicenter, that is, in this case from the place of formation of a bubble of the gas phase. When the discharge pressure of the solid phase particles in the extraction mixture serve as centers of vaporization, and most of the bubbles formed directly on the surface of the chitin-containing raw material. The processing of the extraction mixture introduced from the outside by ultrasonic vibrations, as provided in the first stage of extraction in the closest analogue, has a rather low efficiency due to low efficiency of ultrasonic emitters, scattering of ultrasound in the wall of the extraction vessel, the interaction of the input and reflected on the interfaces of the phases of ultrasonic waves in the extraction mixture. Creating shock waves in the liquid ammonia in the extraction mixture in the gas phase, as provided in the third stage extraction in the closest analogue is more effective than the introduction of external ultrasonic vibrations, However, the formation of bubbles of the gas phase in this case occurs at the surface of contact of water and ammonia, that is at some distance from the particles of the extracted raw materials, resulting in the closest analogue in comparison with the proposed method is guaranteed a large share of the energy costs of the destruction of the cell structure of chitin-containing raw material and obtaining hits is on, respectively. It should be noted that the destruction of the cell structure of materials under the action of shock waves begins with minor changes, the speed and the depth of which is increasing with the accumulation of fatigue stresses in raw materials. The destruction of the cellular structure of the raw materials and the kinetics of extraction in this case is determined by the known laws (Vasenkov I. improving the technology of production and application of extracts of plant materials in the food industry. Dis. Ph.D.): VNIIKOP-Rossiter, 1996 - 42 C.). In this case, since the changes are irreversible, periodic reset and the pressure increase in the extraction mixture should be implemented at the first stage of extraction. When you reset and the pressure in the extraction mixture not only at first, but the later stages of the extraction process intensifies in comparison with the closest analogue from the stage of extraction, in addition to the first, where the next discharge and the pressure increase in the extraction mixture. The intensification of the process in this case is estimated by the known laws (Tyrsin Y.A. Intensification of hydrolysis in biotechnology and the food industry. Abstract of thesis. Dr.): MHAPP, 1993 - 54 C.). Obtained according to the described technology product complies with THE 9289-026-4511441-01 and provided for their physico-chemical and sensory characteristics different from those obtained for the closest analogue to the values not exceed the errors of their determination. Experiments have shown that the reduction of specific energy consumption in comparison with the closest analogue in the proposed method ranges from 23% to 4% when the discharge pressure only at the first stage and at all stages of extraction, respectively. At the same time, the manufacturing cycle may be equal to the closest analogue or reduced by 24% without sacrificing the quality of the target product with the same boundary conditions. Thus, the proposed method allows to reduce the specific energy consumption, and possible ways of its implementation to further reduce the duration of the technological cycle. Method for the production of chitosan, which provides the consistent extraction of chitin-containing raw material nonpolar liquefied gas, water, alkali, water, acid, water, alkali and water to obtain the desired product as a solid residue, characterized in that at least at the first stage of extraction pressure in the extraction mixture is periodically reset to the value that provides the lash of the extractant, and increase to its original value.
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