Microwave heat based frostbite therapy |
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IPC classes for russian patent Microwave heat based frostbite therapy (RU 2360713):
Treatment method for patients suffering from complicated trauma of limbs / 2353410
Invention refers to medicine and covers treatment of the patients suffering from complicated trauma of limbs. In postoperative period an injured site of limb is exposed to electromagnetic field generated by the first exposure cell. At the same time the patient trunk is exposed to electromagnetic field generated by the second exposure cell, while the injured limb is exposed to acoustic vibrations of low-frequency range by the third exposure cell. The first exposure cell represents two series inductance coils matched and connected to an oscillatory circuit of the first self-excited oscillator. The electric field intensity of each coil surface is 1-3 V/m. The second exposure cell represents two series inductance coils matched and connected to the second self-excited oscillator circuit, and in-built in one plane. The self-excited oscillators generate sine-wave oscillation of carrier frequency within 200-500 kHz amplitude-modulated with a low-frequency signal of constantly changing frequency within 50-10000 Hz. The third exposure cell comprises acoustic radiators. Acoustic vibrations of audio frequency are generated with a low-frequency signal with constantly changing frequency and amplitude within frequency range 50-10000 Hz. Acoustic radiation density of acoustic radiator surface is 0.1-0.5 Wt/cm2.
Method of reduction of increased functional activity in adrenal gland cortex for experiment in vivo / 2349353
Invention concerns experimental medicine and is intended for reduction of functional activity of adrenal gland cortex for experiment in vivo. Breast xiphoid appendix area of white rats is exposed to radiation of electromagnetic waves of Teraherz range with 150, 176-150, 664 GHz frequencies for 15 minutes. Radiation power density is ˜ 0.2 mW/cm2.
 Method of refractory wound treatment in experiment / 2349326
Invention concerns medicine, particularly experimental surgery. Wound surface is daily affected by gaseous ozone of 5 mg/l concentration at output of aggregate and gas flow rate of 1 l per minute for 30 minutes. Local irradiation by millimetre waves of SWF band with 'white noise' type spectre within 53.57-78.33 GHz is performed for 20 minutes.
 Method of coronary disease treatment / 2349296
Invention concerns medicine, particularly cardiology. Starting from the 2nd day of adaptation period patient undergoes extremely high frequency therapy with 4.9 mm wavelength. Starting from the fifth day of treatment radon balneotherapy with radon concentration of 40-60-80 nCi/l is added. First balneological procedure duration is 6 minutes, second procedure is 8 minutes, third one is 10 minutes, and fourth one is 12 minutes, the other procedures of 15 minutes each are performed over a day for the course of 10 physiological procedures and 8 balneological procedures. Bath procedures 1-4 are performed with radon concentration of 40 nCi/l, procedures 5-6 - 60 nCi/l, procedures 7-8 - 80 nCi/l.
Method of treatment and prevention of nonspecific inflammatory genital diseases in animals / 2345802
Vaginal or rectal region or biologically active points of sacrolumbar are daily exposed to electromagnetic millimetre radiation at frequency either 65 GHz, or 129 GHz, or 300 GHz. Biologically active points are exposed during 3-5 min per each active point designated for genital activity. Rectal exposure is takes 1-2 minutes. Vaginal exposure involves neck of uterus and mucous membrane of vagina within 1-2 minutes.
Treatment method for primary hypertension patients / 2344852
To treat primary hypertension patients, than November March and July to August periods, balneo- and EHF-therapy are conducted daily, according to schedule as follows: from 11 to 15 o'clock, EHF procedures; from 14 to 16 o'clock, balneotherapy. Than April to June and September to October periods, balneotherapy and self-control energoneuroadaptive electrostimulation (SCENAR-therapy) are conducted from 9 to 11 o'clock, with high amplitude pulse bipolar current and biological feedback, 60 Hz frequency; procedure duration being 20 to 25 minutes. Exposure is conducted daily on collar area by gradual current increase until distinct painless vibration under the electrode is occurred; the technique being labile, course includes 10 procedures. EHF exposure is conducted on corporal biologically active spots by electromagnetic radiation with 60.9-61.3 GHz frequency, as follows: VC-17, E-36 (double), TR-5 (double), VG-20; exposition time being 3 to 5 minutes on each spot, total procedure duration 20 to 30 minutes, time from 11 to 15 o'clock, course includes 10 procedures. General iodide-bromine bath of concentration 20 g/l, temperature 36-37°C, during 10 minutes, are taken every other day from 14 to 16 o'clock, course includes 10 procedures.
Method of treatment and prevention of gastroenteric disorders at animals / 2343942
Electromagnetic radiation of EHF range on frequencies of 65 GHz either 129 GHz or 300 GHz consistently influence on stomach BAT, cholic bubble and rectum during 1-2 mines on each area daily.
Method of lowered concentration of nitrites in blood plasma in conditions of stress restoration / 2342961
Area of the xiphoid appendix of the white rats that are in a condition of accute immobilisation stress, are irradiated with electromagnetic waves of terahertz range. Use frequencies of molecular spectrum of radiation and absorption of nitrogen oxide of 150.176-150.664 GHz, power density of 0.2 mW/cm2. An irradiation is spent within 30 minutes.
Method for treatment of hepatitises / 2342922
Method comprises the basic medicamental therapy and exposure with electromagnetic pulses of extremely high frequency (EMP EHF) in noise amplitude over acupuncture points. Electrocutaneous conductivity is measured in points-supporters of right and left canal branches of liver. If the index of electrocutaneous conductivity is higher on the left than one on the right, points of the left canal branch of liver F.3 and F.13 is exposed, and bracing points GI.4 and E.36 on the left are also exposed. In case if the index of electrocutaneous conductivity of the right canal branch of liver is higher, only bracing points GI.4 and E.36 are exposed on the left, and additionally the point Y.12 of anterior medial canal is exposed.
 Device for regulating physiological processes in biological object / 2341851
Proposed device for regulating physiological processes in a biological object comprises a power supply source, connected to a semiconductor device, the active layer of which contains a semiconductor structure based on a A3B5 compound. The semiconductor device has a voltage-current curve with a region with negative differential conductivity, the value of which exceeds the differential conductivity of the biological object. The semiconductor device can be in form of a Gunn diode, tunnel diode, BARRIT diode or transistor. The semiconductor structure can have at least two working objects from the same or different A3B5 compounds with different geometrical dimensions.
 Device for stimulating bone tissue regeneration / 2243793
Device has power supply source, electromagnetic oscillation source, treatment element, having two inductance coils connected in series and compliance, and capacitor forming an LC-circuit with the treatment element. The electromagnetic oscillation source is designed as self-excited oscillator, which oscillatory circuit is the LC-circuit with the treatment element. The device also has modulator unit set between the power supply source and self-excited oscillator circuit, control circuit connected to the self-excited oscillator circuit and having amplitude detector, AC amplifier and indicator unit connected in series and sectional U-shaped dielectric carcass having inductance coils of the treatment element mounted on its vertical elements and electric units of the device mounted on horizontal electric elements of the device. The self-excited oscillator produces high frequency oscillations in frequency bandwidth of 100-1000 kHz. The modulator unit has low frequency oscillator operating in the bandwidth of 10-5000 Hz. Carcass members are manufactured from hard dielectric material and connected to each other by means of flexible connection members.
 Method for preventing immunodeficiency in experiment / 2243794
Method involves exposing thymus to microwaves of millimetric bandwidth and wavelength equal to 5.6 mm. Single exposure time is equal to 1-2 min with total number of procedures, given every second-third day, being equal to 6. Immunodeficiency model is reproduced at the second day after having accomplished the procedures by combining hexenal anesthesia and abdominotomy followed by immobilization stress accompanied with immunological value control 5 days after reproducing the model.
Method for treating the cases of chronic generalized periodontitis of mild and moderate severity degree / 2248785
Method involves applying pharmacotherapy, taking Calcium Biophick and Complevit. Biologically active points and periodontium tissues are exposed to electromagnetic radiation of extremely high frequency. Noise electromagnetic radiation is used in bandwidth of 53.57-78.33 GHz and specific power of 1.0-4.0 mcW/cm2 with nonuniform noise spectrum frequency distribution no exceeding ±3 dB. First, biologically active point of He-Gu is treated on the right and left arm in turn during 5-7 min. Then, periodontium area is acted in transition fold projection on maxilla and mandible on vestibular side in turn in perpendicular to area under radiation treatment during 10-15 min. The total treatment course is 6-9 daily sessions long.
 Method for treating children and teenagers for scoliosis / 2248822
Method involves exposing motor activity points of injured dorsal muscles to pulsating extremely high frequency noise radiation in bandwidth of 52-78 GHz, duration of 1 mcs, mean power flow intensity of 0.85 mcW/cm2. Their tonus is to be determined in advance. Tonus being initially high, the daily treatment session is 5-8 min long. Tonus being initially low, the daily treatment session is 2-4 min long. The total treatment course is 8-15 procedures long.
 Method and device for treating the cases of epilepsy / 2249471
Method involves concurrently treating brain with longitudinal and transverse electromagnetic fields caused by high frequency sinusoid signals having carrier frequencies belonging to 200-1000 kHz bandwidth amplitude-modulated with low frequency signals having continuously variable frequency in frequency bandwidth of 4-24 Hz. Treatment is applied by means of two action elements of transverse electromagnetic field bitemporally placed and one longitudinal electromagnetic field action element manufactured as resonance LC-contour. The device has power supply source, electromagnetic oscillation source and two action elements. The electromagnetic oscillation source is manufactured as active oscillator which carrier frequency belongs to 200-1000 kHz bandwidth.
Method for applying reflexogenic therapy / 2253431
Method involves detecting pathological changes and setting diagnosis. Biologically active points corresponding to the disease and points or zones of Zakharyin-Gedda with low electric resistance are determined. Constant action is first applied to them with DC intensity of 1-10 mcA. Electric stimulation intensity is increased to reach sensory response of a patient. Then, magnetic infrared laser therapy is applied.
 Method for treating patients with osteoarthrosis / 2256470
One should affect with balneo-, peloido-, EHV-therapy daily at the following sequence: 9 - 11 a.m. - balneotherapy, 8-10 procedures/course, 11 a.m. - 1 p.m - therapy, 10 procedures/course, 2 p.m. - 4 p.m.- peloidotherapy, 8-10 procedures/course. Moreover, about 2-3 d before this impact one should prescribe a food additive as succinic acid at the dosage of 0.5 g thrice daily after meals for 14 -16 d. The method enables to shorten the frequency of appearance and degree of balneoreactions, shorten therapy terms without any decrease of productivity.
 Method of treating posttraumatic stress disorders / 2257238
Before treatment, condition of vegetative nervous system is examined and, when initial vegetative tonus is regarded as sympathicotonia and hypersympathicotonia, galvanization of collar region according to Shcherbak and common-use pearl bathes are recommended. When initial vegetative tonus is regarded as vagotonia, microwave therapy and common-use radon bathes are recommended.
Method for treating uterine myoma in combination with mastopathy / 2257921
One should affect biologically active points as VC-17 and RP-6 with electromagnetic waves of mm-range in interval of 60.0-61.8 hHz and density of power flow of 1.0-1.5 mW/sq. cm. Every female patient should be affected with individually matched frequency with the help of "Stella 2 " apparatus with an in-built electroconductivity indication block of acupuncture points for 14-16 min/each beginning since the 5th-7th d of menstrual cycle daily from 9 a.m. till 12 a.m. The rapeutic course consists of 10-12 procedures. The method enables to demonstrate direct depressive action towards any tumor growth.
 Method for treating idiopathic eczema under out-patient conditions / 2257922
At the background of hyposensitizing therapy in combination with applying means of external ointment therapy one should affect with electromagnetic waves of non-heat intensity. One should perform combined impact with the bundle of electromagnetic waves of non-heat intensity at frequency and amplitude modulation from "Yav'-1" apparatus supplied with "Yasnost'" adapter at wave length being 5.6 nm directly onto lesion foci. Course of therapy consists of 12 daily procedures, for 20 min/each. The method enables to interrupt clinical symptomatology at earlier terms.
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FIELD: medicine. SUBSTANCE: therapy involves microwaves supplied to a frostbitten limb SHF from different sides. The radiated power is 15 to 30 W. Exposure duration is set within 20-30 minutes. EFFECT: optimal therapeutic effect ensured by uniform heating of tissue and restoration of micro- and macrocirculation in the entire space of an affected limb with elimination of thermal damage of tissue. 4 cl, 2 dwg
The invention relates to medicine, specifically to surgery and traumatology, and is intended to reduce the severity of the impact of cold injury. Frostbite according to domestic and foreign authors up to 15% of all trauma cases (in military time up to 25% health loss) [Kotelnikov VP Frostbite. - M.: Medicine, 1988. - 256 S.]. Disability with deep lesions ranges from 20-90%. The number of frozen reaches 20% of hospital beds. The vast number of affected are people in the most productive age from 20 to 50 years, with deep frostbite 65%. Most often in clinical practice, there are frostbite of the extremities [Morazan RI. Frostbite of the extremities. - M.: Medicine, 1984. - S.], because more severe cases, usually fatal. Modern level achieved in the treatment of frostbite, reflected in the publication [Proceedings of the Third scientific and practical conference on "Cold injury". - St. Petersburg, April 8, 2002 // S-IB.: Publishing house of the military medical Academy, 2002. - 90 S.]. The main therapeutic action with deep frostbite are conservative in nature. Using traditional methods, the duration of treatment in hospitals is on average 65 days. Disability is determined by the outcome of up to 70%mortality 6%. In affect, the, there is an objective need for an effective and popular way to treat frostbite. Despite the importance of specialized techniques in the treatment of frostbite does not exist. Meanwhile, in the first two or three days after cold injury there is the possibility to exclude its irreversible consequences. The main damaging factor is, as a rule, the spasm of blood vessels, leading to the termination of the supply of tissues. The spasm is a protective reaction of the body, aimed at isolation of the affected segment in order to preserve the vital organs. Restoring vascular microcirculation able to restore occurred in the tissues of the violation, to prevent the appearance of necrosis and loss of limb segments. Of particular importance is the impact on spastic blood vessels in the depth of the affected segment. Surface heating by known means not solve this problem and even worsens the situation, as the lack of power from the remaining spazmirovanne deep vessels leading to ischemia otogretogo tissues that need oxygen and nutrition, and removal of metabolic products. The most known methods of treatment of frostbite, such as the use of heaters water tanks, etc. are extremely distant analogues offer the invention. There is a method of treatment of frostbite in the patent ["Way to treat frostbite" EN 2212210, publ. 20.09.2003], one part of which is the use of microwave heating. Microwave radiation can penetrate into the tissues, which distinguishes this method from the traditional ways. When implementing this method frostbitten limb is placed between two electrodes and forming between them in the microwave, which quickly warm the tissue to a temperature 12-41°C. When the power flux-density is about 3 W/cm2. The process is accompanied by injecting drugs. The method has several significant disadvantages. First of all, it does not provide the uniformity of the microwave field, resulting fabric are heated unevenly. In the patent (RU 2212210) States that in the implementation of the method, the temperature difference in the thickness of the object reaches 29 degrees, namely: from 12 to 41, that is, from the threshold values for the resumption of blood flow to a value close to the threshold of the destruction of tissue. A small deviation in time or power shifts the temperature range upward, then burn tissue or downward, and then is not achieved removal of vascular spasm. Meanwhile, the deviation is inevitable, considering the actual configurations, the Yu limbs - thicker proximal portion, where the field strength and intensity of heating will be smaller and thinner distal portion, where the field strength and intensity of heating will be greater. As a result, when implementing the method according to the patent (RU 2212210) the probability of additional thermal tissue damage. Applicants on the basis of multiple experiments on animals have found that the radiation power, creating the effect of rapid warming, really causes thermal damage. First, it is invisible against the background of frostbite, but in the future (5-6 a day) leads to massive destruction of tissue, the development of gangrene and the need for limb amputation. Thus, there is a method of treatment of frostbite needs improvements related to the establishment of power and time of microwave exposure. In addition, the known method is characterized by increased trauma caused by repeated introduction of drugs into tissues exposed to frostbite. The closest analog is selected as a prototype method, implemented in the patent ["microwave oven", EN 2196620 A61N 5/02, epubl]. It is used refurbished microwave oven equipped with a means of deciding microwave radiation dosage level is Amnesty to the object impacts from multiple sides. This is made more uniform heating of the object of influence. The microwave oven operates in the frequency range of about 2450 MHz (wavelength of 12 cm), highlighted in the world practice for various applications associated with microwave heating. In the specified range are industrial, household and medical facilities and there is a solid technical base for the creation of new instruments and methods. Uniform heating of the microwave radiation applied from several sides, leads to the recovery of micro - and macro-circulation in the entire volume of the affected limb, including the depth where the main feeding vessels. In the result, the surface layers during the annealing does not suffer from lack of oxygen and nutrients, as well as from accumulating metabolic products. The disadvantage of this method is the uncertainty of the modes of microwave heating, providing effective treatment of frostbite. The wrong choice of mode may, in case of excess capacity, to result in the destruction of tissue due to overheating, but in the case of lack of capacity to lack of therapeutic effect. Useful result achieved by the invention is to improve the effectiveness of treatment with the exception of thermal destruction of tissue. This result is achieved in that in the process of treatment GCP is rogeni on the principle of microwave heating, includes summing up to a frostbitten extremity of microwave radiation dosed with power level from several sides, the difference is that the input power is set in the range from 15 to 30 W, the duration of exposure to microwave radiation set within 20-30 minutes To ensure long-term therapeutic effect of exposure to microwave radiation is carried out again after 6-8 hours. For thermometric and reovazograficheskie indicators single microwave effect is produced on the second and third day. Optimization of therapeutic effect is achieved by the fact that prior to the first microwave influence on frostbitten limb impose insulating cotton-gauze bandage. The reachability of the declared result confirmed by the following: 1. The power of the microwave radiation applied to the frostbitten limbs, ranging from 15 to 30 watts of power ensures that over time the impact of homogeneous and gradual warming of the frostbitten limbs with control recovery of physiological functions through thermometry and days. Experimentally it is found that the announcement to the object the microwave radiation at a power not exceeding the specified limit, prevents local overheating of the tissue at any volume and configuration of the segments of the limb. At levels of microwave power and, greater than 30 W, the possible local overheating affecting the outcome of treatment. When the level of microwave power less than 15 watts therapeutic effect fails to occur during the impact. 2. Setting the duration of microwave exposure within 20-30 minutes provides simultaneous heating of tissues to a temperature corresponding to the cessation of spasm of the blood vessels and restore blood flow. Temperature range satisfying this condition ranges from 20 to 40°C. the Lower limit of the exposure time to 20 minutes corresponds to the minimum temperature from the specified interval in a typical volume of affected object (hand, foot). The upper limit of the exposure time to 30 minutes is limited to the requirements of GOST R 50267.6-92 "medical electrical part 2: particular requirements for the safety of the devices for microwave therapy". 3. Re (6-8 hours) application of microwave exposure provides a consolidation of simultaneous therapeutic result. Experimentally observed that for these 6-8 hours marked lowering the temperature of the affected limb at 5-8° relative to the normal temperature. It is established that repetition prevents recurrence of acute pressure provides for the maintenance of vascular micro - and macro-circulation and normalizes the temperature for a long time. 4. The procedure of microwave exposure on 2 and 3 day required under relatively severe frostbite when the restoration of vital functions of tissues requires a large time. Indications for this procedure are lowering the temperature of 5-8°C and the decrease in the rheological index to the level of 0.5-0.6 from the norm. 5. Overlay on frostbitten limb thermal insulating cotton-gauze bandage prior to the first microwave influence to prevent premature heating and accompanying him ischemia surface layers frostbitten limbs, not receiving adequate nutrition due to spasm of deep vessels. Thus, the combination of stated characteristics of the treatment for frostbite by microwave heating provides effective treatment and eliminates thermal tissue damage. The invention is illustrated by graphic illustrations figure 1-2. Figure 1 shows a graph of depth temperature frostbitten limbs in the course of the experiment. Figure 2 is a graph illustrating the dynamics of blood flow restoration in frostbitten limbs experimental animal. The device used in the implementation of the method of treatment of frostbite on the principle of microwave heating, contains a source of microwave radiation and means for summing the object of influence. The source is the RF oven. Means for summing the microwave radiation dosed with power to the target can be represented, for example, used in the method prototype set of emitters associated with the internal volume of the furnace by means of cables and probes. In the implementation of the method of treatment according to the principle of microwave heating on the subject - limb suffered frostbite, direct from different sides of the stream of microwave radiation with measured power level The difference of the proposed method is that the power level of the radiation applied to the target set in the range from 15 to 30 watts. This limitation was established experimentally by studying the dynamics of microwave heating of various objects: containers with water, chicken legs, limbs experimental animals (rabbits). Surface and deep water temperature was monitored using a thermocouple placed in the opening of the channel of the surgical needle. It is established that the excess of 30 watts may cause local overheating of the tissues that are detrimental to long-term treatment outcome. At the same time, the specified level, provided that it is not less than 15 watts is enough for the time of microwave exposure, comprising the claimed method for 20-30 minutes, raise the temperature of the object to a value within the interval, according to stuudy viable state of the biological object. This interval ranges from 20° to 40°C. The need to repeat the procedure of microwave heating in 6-8 hours due to the development of tissue edema, subjected to cold injury, and the associated difficulty of vascular micro - and macro-circulation. Figure 1 shows the time dependence of the temperature frostbitten limbs. Within a few hours after the initial microwave exposure temperature is somewhat reduced. Repeated microwave exposure restores the temperature and prevents its subsequent decline. In the case of severe frostbite may single repetition of the procedure on the second and third day. In figure 2, the solid curve shows the time dependence relations reovazograficheskie (RVG) indexes frostbitten and healthy limbs rabbit with a single microwave exposure. It is seen that without repeating the procedure, the blood flow is hampered for the past 4-5 days, which is manifested in the decrease RVG index frostbitten limbs in comparison with healthy konechnostey. The dashed line on the same figure 2 shows the time dependence of the ratio of EGR indexes by repeating the procedure of microwave heating. Show a pronounced effect of stabilization, which indicates the achievement of an optimal therapeutic effect. The specificity of cold injury is that when going into a warm room in the first place is togravity surface layers, however, the resumption of metabolism in them takes place in conditions continue spasm of deep vessels, i.e. without taking food and remove waste products. To prevent the negative effects of premature thawing of the surface layers of the affected limb is isolated from the flow of external heat cotton-gauze bandage. Experiments on live rabbits was carried out from the initial tissue temperature in the range from 0 to minus 5°C. Immediately after cooling and until the beginning of the procedure of microwave effects on limb superimposed insulating cotton-gauze bandage thickness of 5 cm Interval between the end of the cooling and the beginning of the microwave heating ranged from 30 minutes to 3 hours. Average power microwave heating from 15 to 30 watts, lasting from 20 to 30 minutes. Measurements of interstitial temperature at the surface and at depth within 6 days showed stabilization at 37-40°C. the Temperature is raised due to post-traumatic inflammatory response. There is swelling of the limb that is stabilized by the end of the first day. On rheovasogramme characterizing the condition of blood circulation (arterial, venous component, the microcirculation), for all 6 days determined by the presence of arterial inflow and outflow in the limb. On the second day frostbitten capactive involved in the movement, on the fourth day, the swelling is reduced, the animal can pinch frostbitten foot. The skin in some places rejected small fragments. On the 6th day frostbitten limb remains viable. Animals removed from the experiment. Additional advantages of the proposed method is the possibility to extend the scope of its application in different types of vascular pathologies. 1. Treatment of frostbite on the principle of microwave heating, comprising summing up to a frostbitten extremity of microwave radiation dosed with power level from several sides, characterized in that the input power is set in the range from 15 to 30 W, the duration of exposure to microwave radiation set within 20-30 minutes 2. The method according to claim 1, characterized in that the microwave exposure is carried out again after 6-8 hours 3. The method according to claim 1, characterized in that the temperature and reovazograficheskie indicators single microwave effect is produced on the second and third day. 4. The method according to claim 1, characterized in that prior to the first microwave influence on frostbitten limb impose insulating cotton-gauze bandage.
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