Method of treatment and prevention of nonspecific inflammatory genital diseases in animals

IPC classes for russian patent Method of treatment and prevention of nonspecific inflammatory genital diseases in animals (RU 2345802):

A61N5/02 - using microwaves (A61N0005010000 takes precedence);;

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Method for treating idiopathic eczema under out-patient conditions / 2257922

At the background of hyposensitizing therapy in combination with applying means of external ointment therapy one should affect with electromagnetic waves of non-heat intensity. One should perform combined impact with the bundle of electromagnetic waves of non-heat intensity at frequency and amplitude modulation from "Yav'-1" apparatus supplied with "Yasnost'" adapter at wave length being 5.6 nm directly onto lesion foci. Course of therapy consists of 12 daily procedures, for 20 min/each. The method enables to interrupt clinical symptomatology at earlier terms.

FIELD: medicine; veterinary science.

SUBSTANCE: vaginal or rectal region or biologically active points of sacrolumbar are daily exposed to electromagnetic millimetre radiation at frequency either 65 GHz, or 129 GHz, or 300 GHz. Biologically active points are exposed during 3-5 min per each active point designated for genital activity. Rectal exposure is takes 1-2 minutes. Vaginal exposure involves neck of uterus and mucous membrane of vagina within 1-2 minutes.

EFFECT: higher rate of fertilisation after recovering, higher safety, reduced time of treatment in different kinds of animals, lower disease rate in animal yield and number of sterility days.

4 cl, 12 tbl, 3 ex

The invention relates to the field of veterinary medicine and can be used for the treatment and prevention of nonspecific inflammatory diseases of the genital organs in animals, such as vaginitis, vestibulodynia, cervicitis, subinvolution of the uterus, endometritis various origins.

Know the use of various drugs for the treatment of inflammatory processes in animals, such as foramena (see RF patent № 2139709, IPC AC 36/00).

Known methods of treatment of cows with acute and chronic vestibulospinal, cervicitis, subinvolution of the uterus, endometritis, including the use of antibiotics, hormonal stimulant drugs (Mikhailov (MOSCOW, Parshutin, G.V. Kozlov, N.E. Obstetrics, gynecology and artificial insemination of farm animals. M: Agropromizdat, 1990, s-500).

However, these methods are often accompanied by side effects and low efficacy of the treatment. Moreover, antibiotics and hormones are released through the food in the human body, which is undesirable, and sometimes invalid.

There is a method of treatment of gynecological diseases in cows the influence of an alternating magnetic field (Ed. mon. The USSR 1255150, CL 61N 1/32, 1986) by the local alternate within 3-5 minutes of exposure to the cervix, and the rump when the value m is xymalos tension alternating magnetic field in the patient's body 1-4 T when the pulse frequency of 0.25-10 Hz and pulse duration of 0.1 to 1.0 milliseconds.

The disadvantages of this method lies in the high complexity, the possibility of an additional infection of the uterus.

Closest to the proposed solution is a method of treatment of inflammatory processes of the productive organs of animals by means of high-frequency therapy, including rectal placement of the irradiator in the dielectric housing and the impact of physical factors on the area of the reproductive organs. The impact carried out through the rectum wall of the high-frequency magnetic field, and additionally carry out impact on the region of the nerve plexus lumbar, pelvic area and spine (see RF patent № 2077350, IPC A61N 5/02).

The disadvantage is the possibility of trauma and the inability to apply for small ruminants, pigs, dogs and cats, the lack of effectiveness of the treatment, a high probability of spread of these diseases from one animal to another when assigning data treatment procedures.

The task of the technical solution is the creation of environmentally safe non-medicated antiseptic treatment and prevention of nonspecific inflammatory diseases of the genital organs in animals while improving the efficiency and reducing treatment time.

The problem is solved in that in the method of treatment and the pros who ACTICE nonspecific inflammatory diseases of the genital organs in animals including the effects of physical factors on the genitals of animals, according to the decision of the influence exercised by electromagnetic radiation of millimeter range on one of the resonant frequencies of the molecular spectrum of atmospheric oxygen, the effect of exercise vaginal and/or rectal impact, and/or BAT Sacro-lumbar daily for 5-7 days.

The impact on the BAHT is carried out for 3-5 min each AT responsible for the activity of the genital organs.

Rectal exposure is carried out for 1-2 minutes

Vaginal effects of exercise on the cervix and/or the mucous membrane of the vagina for 1-2 minutes

The impact carried out at a frequency of 65 GHz, or 129 GHz and 300 GHz.

The method is as follows. The effects of electromagnetic radiation of millimeter range operate at the resonant frequencies of molecular absorption spectrum and emission of atmospheric oxygen. Exposure is carried out for 1-2 minutes on each area on a daily basis. Irradiation is carried out at frequencies of 65 GHz, or 129, or 300 GHz, for example, using short-wave generator - panoramic-spectrometric complex with the quasi-optical reflectometer operating in the frequency range 118-600 GHz or apparatus "Universal-M at a frequency of 65 GHz.

Choice h is the frequency of the radiation is due to the fact, what these frequencies, the normalization of microcirculation of blood in the sex organs, improves metabolism in the diseased tissues, restores the histostructure of the mucous membranes of the genital organs, which was established by us experimentally.

70,0

Table 1 The effectiveness of therapy of nonspecific inflammatory diseases of the genital organs, depending on time and sequential modes vaginal and rectal effects,%
The exposure time	65 GHz	129 GHz	150 GHz	300 GHz
rectal	vaginally	rectal	vaginally	rectal	vaginally	rectal	vaginally
0,5	50,0	50,0	60,0	60,0	60,0	60,0	50,0	60,0
1,0	60,0	60,0	70,0	70,0	70,0	70,0	70,0	60,0
1,5	70,0	70,0	70,0	70,0	80,0	80,0	80,0
2,0	80,0	80,0	80,0	80,0	80,0	70,0	80,0	80,0
2,5	70,0	70,0	80,0	80,0	80,0	70,0	70,0	80,0

Table 2 The effectiveness of therapy of nonspecific inflammatory diseases depending on the time when exposed to BAHT Sacro-lumbar,%
The exposure time	65 GHz	129 GHz	150 GHz	300 GHz
2,0	60,0	70,0	70,0	70,0
3,0	70,0	80,0	80,0	90,0
4,0	70,0	80,0	70,0	90,0
5,0	70,0	80,0	80,0	90,0
6,0	50,0	80,0	70,0	80,0

Table 3. The effectiveness of therapy of nonspecific inflammatory diseases of elovich bodies depending on time and modes of vaginal and rectal impacts in combination, in %
The exposure time	65 GHz	129 GHz	150 GHz	300 GHz
Vaginally rectal	Vaginally rectal	Vaginally rectal	Vaginally rectal
0,5	50,0	650	60,0	550
1,0	650	70,0	75,0	70,0
1,5	70,0	75,0	80,0	850
2,0	85,0	850	850	850
2,5	75,0	80,0	80,0	70,0

Experiments with simultaneous vaginal, rectal and impact on BAT lumbosacral at different timing modes and different frequencies showed that the effectiveness of the proposed method in most animals is 65-80%.

Example. 1 In cattle.

Table 4 Hematological changes in the application of EMR EHF therapy of nonspecific inflammatory diseases of the genital organs in cattle
Indicators	Before the treatment	After the treatment
ESR, mm/g	1,1±1,19	1,2±0,18
Hemoglobin, g/l	7,87±0,58	8,48±0,34^*
The number of leukocytes, g/l	5,47±0,41	by 5.87±0,46
The number of erythrocytes, g/l	4,56±0,23	5,09±0,13^*
Leukogram, %
Basophils	0,30	0,40
Eosinophils	6,20	4,21
Neuropile:
P	1,75	3,28
	of 31.4	35,8
Lymphocytes	58,4	54,9
monocytes	1,1	2,4
Total protein, g/l	71,27	83,87
Glucose, mmol/l	1,41±0,16	1,932±0,17^*
Carotene, mg/%	0,008±0,02	0,235±0,08^***
BASK, %	52,4	58,4
FAN, %	57,0	58,6
IgG, g/l	15,65±1,50	23,76±1,50
IgM, g/l	2,48±0,22	4,07±0,18
IgA, g/l	0,36±0,03	0,535±0,04^**
Note^- hereinafter^p less than 0.05,^p less than 0.01^*0,001

Table 5 The effect of EHF EMR on the contractile function cows
The treatment	The tone of the uterus, %
3 day	6 days
0	+	++	0	+	++
65 GHz	15,8	26,31	57,89	5,26	10,52	84,22
129 GHz	14,2	27,91	57,89	4,6	the 10.1	85,3
150 GHz	10,7	29,1	60,2	4,4	9,9	85,7
300 GHz	12,49	28,3	59,21	7,3	8,9	is 83.8
Traditional (control = 17)	29,4	35,3	35,3	11,76	35,3	5,94
0 - atony + - hypotension ++ - normal uterine contractions

Table 6 Therapeutic efficacy of EMR EHF at frequency 129 GHz sick cows with postpartum pathology
The treatment	Disease	Recovered %	The time of treatment days	The period of treatment before fertilization days	The insemination index	The days of infertility
Offer	Vaginitis	95,8	of 5.89	16,2±of 7.23	1,6	73,9
Cervicitis	78,5	8,65	24,3±6,17	1,9	83,1
Endometritis	2,6	11,84	32,7±5,08	2,2	89,4
Traditional	Vaginitis	87,9	6,9	21,7±of 6.31	1,8	85,7
Cervicitis	68,8	the 9.7	35,8±5,27	2,1	99,3
Endometritis	57,8	15,7	45,8±6,92	2,47	137,5

Table 7 The effectiveness of EMR UHF at a frequency of 150 GHZ range with postpartum complication
Groups of animals	Recovery time, days	Fertilization, %	The insemination index	Number of days for infertility
From 1^thinsemination	Only
Vaginitis (n=17)	5,4±0,32	64,70	100,0	1,4	79,8±2,34
Cervicitis (n=18)	7,5±0,62	61,11	94,44	1,9	91,2±5,35
The subinvolution of the uterus (n=19)	9,7±0,82	57,89	89,47	2,3	107,5±4,89
Endometritis (n=22)	12,4±0,67	50,00	77,27	to 2.67	113,45±6,72

Example 2. In sows.

Table 8 The effectiveness of EMR UHF ranges for the prevention of postpartum diseases in sows
Group	Ill sows, %
Only	Endometritis	MMA
65 GHz	37,45	29,9	7,5
129 GHz	26,5	13,9	3,4
150 GHz	25,8	14,2	3,6
300 GHz	26,0	14,3	the 3.8
Control	78,6	46,4	32,2

Table 9 therapeutic effectiveness of EHF EMR on the frequency of atmospheric oxygen in the treatment of patients sows postpartum complication
Therapies	The average number of procedures	Outcomes % recovery	The time of treatment, days
The proposed (n=19)	Endometritis	7,6	84,21	8,2
MMA	10,7	73,68	11,3
Traditional (n=17)	Endometritis	10,9	76,47	12,1
MMA	15,8	64,71	the 17.3

Table 10 The dynamics of the gain of suckling piglets in the prevention clause is seredovich complications in sows when exposed to frequencies of nitric oxide
Groups of animals	The average number of piglets in Jack	The average weight of piglets (kg)	Average daily weight gain, g	The average litter weight, kg
The offspring from sows with EHF-therapy	1 day	9,10	1,46	-	13,28
day 10	at 8.36	2,81	138	23,05
20 day	to $ 7.91	4,60	182	36,38
30 day	7,27	6,52	203	47,40
The offspring from sows with traditional therapy	1 day	9,18	1,36	-	10,99
day 10	to $ 7.91	2,73	134	20,84
20 day	7,54	4,40	167	32,08
30 day	7,27	6,36	196	45,03

Example 3. In females.

Table 11 therapeutic effectiveness of EHF EMR on the frequency of atmospheric oxygen in the treatment of nonspecific in policlinic diseases of the genital organs in females
Indicators	Recovered %	Number of medical procedures	The time of treatment, days	Restoration of fertility days
Vaginitis	91,85	the 4.7	7,8±0,23	61,7±6,23
Cervicitis	to 73.65	5,3	9,3±0,17	62,9±5,09
Endometritis	60,20	9,2	13,5±0,35	97,9±4,27
Callingit	69,72	10,3	15,7±0,42	123,5±5,99
Oophoritis	70,53	9,8	15,4±0,27	177,2±6,25

Table 12 The blood of dogs with the use of different treatment regimens when exposed to frequencies of nitric oxide
Indicators	Days of research
Before the treatment	5^th	10^th	15^th
ESR, mm/h
experience	12,86±5,18	7,3±0,7	2,1±0,4	1,8±0,3
to the Troll	14,21±1,85	11,1±3,1	5,7±0,6	5,0±0,5
Hemoglobin,
g/l	93,0±5,69	107,8±4,3	113,5± and 4.9	118,6± and 4.9
experience	104,0±4,53	111,7±3,5	117,6±2,9	125,4±3,6
control
Erythrocytes,
g/l
experience	5,3±0,62	6,5±0,5	6,8±0,4	6,5±0,2
control	5,1±0,42	5,8±0,4	6,2±0,3	7,5±0,4
Leukocytes,
g/l	17,2±2,0	10,5±1,1	8,2±0,4	7,9±0,3
experience	17,5±1,6	16,0±1,4	11,9±1,4	9,4±0,3
control

Thus, the application of the method will reduce the treatment time for different species of animals, treatment costs, increase the percentage of fertilization after recovery, animals, increase the safety, the incidence of litter and reduce the number of days of infertility, which significantly increases the economic efficiency of livestock.

1. Method for the treatment and prevention of nonspecific inflammatory diseases of the genital organs in animals, including the effects of physical factors on the genitals of animals, characterized in that the influence exercised by electromagnetic radiation of millimeter range at a frequency of 65 GHz, or 129 GHz and 300 GHz, the effect of exercise vaginal or rectal or BAT Sacro-lumbar daily.

2. The method according to claim 1, characterized in that the impact on the BAHT is carried out for 3-5 min each AT responsible for the activity of the genital organs.

3. The method according to claim 1, characterized in that the rectal exposure is carried out for 1-2 minutes

4. The method according to claim 1, characterized in that the vaginal effects of exercise on the cervix and the mucous membrane of the vagina for 1-2 minutes