Method of lowered concentration of nitrites in blood plasma in conditions of stress restoration |
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IPC classes for russian patent Method of lowered concentration of nitrites in blood plasma in conditions of stress restoration (RU 2342961):
Method for treatment of hepatitises / 2342922
Method comprises the basic medicamental therapy and exposure with electromagnetic pulses of extremely high frequency (EMP EHF) in noise amplitude over acupuncture points. Electrocutaneous conductivity is measured in points-supporters of right and left canal branches of liver. If the index of electrocutaneous conductivity is higher on the left than one on the right, points of the left canal branch of liver F.3 and F.13 is exposed, and bracing points GI.4 and E.36 on the left are also exposed. In case if the index of electrocutaneous conductivity of the right canal branch of liver is higher, only bracing points GI.4 and E.36 are exposed on the left, and additionally the point Y.12 of anterior medial canal is exposed.
 Device for regulating physiological processes in biological object / 2341851
Proposed device for regulating physiological processes in a biological object comprises a power supply source, connected to a semiconductor device, the active layer of which contains a semiconductor structure based on a A3B5 compound. The semiconductor device has a voltage-current curve with a region with negative differential conductivity, the value of which exceeds the differential conductivity of the biological object. The semiconductor device can be in form of a Gunn diode, tunnel diode, BARRIT diode or transistor. The semiconductor structure can have at least two working objects from the same or different A3B5 compounds with different geometrical dimensions.
Method of animal's respiratory apparatus disease treatment / 2341304
Bioactive point (BAP) of respiratory apparatus and nasal region is series exposed to EHF electromagnetic radiation during 2 min at frequencies either 65 GHz or 129 GHz or 300 GHz daily.
 Method for optimisation of vegetative functions of human body and device for its realisation / 2339413
Group of inventions concerns medicine and is intended for optimisation of vegetative functions of a human body. Influence electromagnetic pulse (EMP) in a centimetric range on biologically active zones of a human body on a wavelength equivalent on the linear sizes of each influence zone. Perform exposure with constant energy exposure rate during all session, with peak modulation of a signal quasirandomly varying in a range 20 Hz - 50 kHz and with circular polarisation of radiation. The device for realisation of the method contains the consistently bridged generator of ultrahigh frequencies, the modulator in the form of a pulse generator of the pseudo-random signals, radiating aerial in the form of a flat synphasic antenna grid, and, bridged with each of these blocks, the control block. The aerial is executed with circular polarisation, radiates in a centimeter range and is supplied on a plane by a dielectric lining of the fixed thickness from a transparent material for working frequency range.
Method of alcohol-induced liver injury treatment using extremely high frequencies based therapy / 2337730
Tender zone is exposed with extremely high frequencies at wavelength 7.1 mm in fractional mode at interchanging pulsing 5 minutes and pause 5 minutes. Density of power flow is 6 mWt/cm2. Exposure time is 20 minutes daily, course of treatment is 5-10 procedures.
Method of treatment of stomatologic diseases / 2336915
Invention concerns medicine and is intended for treatment of stomatologic diseases. Perform affecting of organs and oral cavity tissues with electromagnetic radiation of the highest frequency of noise amplitude of 52-78 GHz, modulated by frequency of 9.4 Hz, with information density of 5×10-4 - 8×10-4 mcW/cm2. An ultrasonic head is applied on the affected place or its projection to the skin.
 Method of physical therapy / 2335308
Invention is referred to medicine, physiotherapy. The method includes selection of biologically active zones (BAZ) important for treatment. For this purpose perform measurements of electromagnetic radiation of millimeter wavelength (EMR MM) over an integument in projection of eight zones. Then perform processing of each measured signal by its transformation to the digital form, spectral characteristics calculations. Build two graphic dependences: dependence of intensity of the measured signal in time and distribution of a spectrum of the measured signal. Analyze the received diagrams. If slow or fast oscillatory process of changes of signal strength in time is present on the first diagram and-or exponential dependence of distribution of frequencies is absent on the second diagram, choose BAZ for medical influence. The course of treatment includes not less than 14 sessions of an irradiation of area of an integument projection of the chosen BAZ with low intensity impulsive noise electromagnetic radiation in a frequency range of 0.03-500 GHz within 1.5-3 minutes. After the end of the course perform control measurement EMR MM over an integument in BAZ projection. Similarly perform processing of the measured signal and the analysis of its results. Taking into account the obtained results whether prescribe an additional course of procedures, or cancel treatment. The method increases efficiency of treatment due to selection of biologically active zones and a mode of exposure, necessary for treatment.
Method of treatment of pathological dependence on negative factors / 2335277
Invention relates to psychiatry. At the beginning of session rational non-directive psychotherapeutical action is performed. Then main and additional corporal and auricular biologically active points (BAP) are subjected to exposure to extremely-high-frequency electromagnetic radiation of non-heat intensity (EHF-radiation). Further resonance therapy is carried out by recording information from BAP on irradiator, which represents Gann diode, switched to EHF-therapy apparatus, which after that is fixed on BAP P1. Duration of one treatment session is 60-90 minutes; course of treatment consists of 3-7 sessions.
 Device for limb frostbite treatment / 2334494
Device for limb frostbite treatment contains SHF-oven, which includes source of SHF radiation and working volume, and means for bringing SHF radiation to object of exposure. Means for bringing SHF radiation to object of exposure is made in the form of separate screened working chamber connected with working volume of SHF oven by window made in their common wall. Separate screened working chamber is supplied with hole, on whose perimeter opening of flexible hose made from metal net placed between fabric layers, is fixed. In addition, in working volume of oven there is radiation absorber made in the form of vessel with water, partially filling oven working volume.
 Method of experimental blood flow linear velocity normalisation in great vessels associated with acute stress-reaction / 2327493
Xiphoid appendix area of albino rats under acute immobilisation stress is exposed to rays. For this purpose, electromagnetic waves of gigahertz frequency range of power 0.7 mW are applied within frequency range of nitrogen oxide radiation and absorption 150.176-150.664 GHz during 5 minutes.
 Device for stimulating bone tissue regeneration / 2243793
Device has power supply source, electromagnetic oscillation source, treatment element, having two inductance coils connected in series and compliance, and capacitor forming an LC-circuit with the treatment element. The electromagnetic oscillation source is designed as self-excited oscillator, which oscillatory circuit is the LC-circuit with the treatment element. The device also has modulator unit set between the power supply source and self-excited oscillator circuit, control circuit connected to the self-excited oscillator circuit and having amplitude detector, AC amplifier and indicator unit connected in series and sectional U-shaped dielectric carcass having inductance coils of the treatment element mounted on its vertical elements and electric units of the device mounted on horizontal electric elements of the device. The self-excited oscillator produces high frequency oscillations in frequency bandwidth of 100-1000 kHz. The modulator unit has low frequency oscillator operating in the bandwidth of 10-5000 Hz. Carcass members are manufactured from hard dielectric material and connected to each other by means of flexible connection members.
 Method for preventing immunodeficiency in experiment / 2243794
Method involves exposing thymus to microwaves of millimetric bandwidth and wavelength equal to 5.6 mm. Single exposure time is equal to 1-2 min with total number of procedures, given every second-third day, being equal to 6. Immunodeficiency model is reproduced at the second day after having accomplished the procedures by combining hexenal anesthesia and abdominotomy followed by immobilization stress accompanied with immunological value control 5 days after reproducing the model.
Method for treating the cases of chronic generalized periodontitis of mild and moderate severity degree / 2248785
Method involves applying pharmacotherapy, taking Calcium Biophick and Complevit. Biologically active points and periodontium tissues are exposed to electromagnetic radiation of extremely high frequency. Noise electromagnetic radiation is used in bandwidth of 53.57-78.33 GHz and specific power of 1.0-4.0 mcW/cm2 with nonuniform noise spectrum frequency distribution no exceeding ±3 dB. First, biologically active point of He-Gu is treated on the right and left arm in turn during 5-7 min. Then, periodontium area is acted in transition fold projection on maxilla and mandible on vestibular side in turn in perpendicular to area under radiation treatment during 10-15 min. The total treatment course is 6-9 daily sessions long.
 Method for treating children and teenagers for scoliosis / 2248822
Method involves exposing motor activity points of injured dorsal muscles to pulsating extremely high frequency noise radiation in bandwidth of 52-78 GHz, duration of 1 mcs, mean power flow intensity of 0.85 mcW/cm2. Their tonus is to be determined in advance. Tonus being initially high, the daily treatment session is 5-8 min long. Tonus being initially low, the daily treatment session is 2-4 min long. The total treatment course is 8-15 procedures long.
 Method and device for treating the cases of epilepsy / 2249471
Method involves concurrently treating brain with longitudinal and transverse electromagnetic fields caused by high frequency sinusoid signals having carrier frequencies belonging to 200-1000 kHz bandwidth amplitude-modulated with low frequency signals having continuously variable frequency in frequency bandwidth of 4-24 Hz. Treatment is applied by means of two action elements of transverse electromagnetic field bitemporally placed and one longitudinal electromagnetic field action element manufactured as resonance LC-contour. The device has power supply source, electromagnetic oscillation source and two action elements. The electromagnetic oscillation source is manufactured as active oscillator which carrier frequency belongs to 200-1000 kHz bandwidth.
Method for applying reflexogenic therapy / 2253431
Method involves detecting pathological changes and setting diagnosis. Biologically active points corresponding to the disease and points or zones of Zakharyin-Gedda with low electric resistance are determined. Constant action is first applied to them with DC intensity of 1-10 mcA. Electric stimulation intensity is increased to reach sensory response of a patient. Then, magnetic infrared laser therapy is applied.
 Method for treating patients with osteoarthrosis / 2256470
One should affect with balneo-, peloido-, EHV-therapy daily at the following sequence: 9 - 11 a.m. - balneotherapy, 8-10 procedures/course, 11 a.m. - 1 p.m - therapy, 10 procedures/course, 2 p.m. - 4 p.m.- peloidotherapy, 8-10 procedures/course. Moreover, about 2-3 d before this impact one should prescribe a food additive as succinic acid at the dosage of 0.5 g thrice daily after meals for 14 -16 d. The method enables to shorten the frequency of appearance and degree of balneoreactions, shorten therapy terms without any decrease of productivity.
 Method of treating posttraumatic stress disorders / 2257238
Before treatment, condition of vegetative nervous system is examined and, when initial vegetative tonus is regarded as sympathicotonia and hypersympathicotonia, galvanization of collar region according to Shcherbak and common-use pearl bathes are recommended. When initial vegetative tonus is regarded as vagotonia, microwave therapy and common-use radon bathes are recommended.
Method for treating uterine myoma in combination with mastopathy / 2257921
One should affect biologically active points as VC-17 and RP-6 with electromagnetic waves of mm-range in interval of 60.0-61.8 hHz and density of power flow of 1.0-1.5 mW/sq. cm. Every female patient should be affected with individually matched frequency with the help of "Stella 2 " apparatus with an in-built electroconductivity indication block of acupuncture points for 14-16 min/each beginning since the 5th-7th d of menstrual cycle daily from 9 a.m. till 12 a.m. The rapeutic course consists of 10-12 procedures. The method enables to demonstrate direct depressive action towards any tumor growth.
 Method for treating idiopathic eczema under out-patient conditions / 2257922
At the background of hyposensitizing therapy in combination with applying means of external ointment therapy one should affect with electromagnetic waves of non-heat intensity. One should perform combined impact with the bundle of electromagnetic waves of non-heat intensity at frequency and amplitude modulation from "Yav'-1" apparatus supplied with "Yasnost'" adapter at wave length being 5.6 nm directly onto lesion foci. Course of therapy consists of 12 daily procedures, for 20 min/each. The method enables to interrupt clinical symptomatology at earlier terms.
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FIELD: medicine. SUBSTANCE: area of the xiphoid appendix of the white rats that are in a condition of accute immobilisation stress, are irradiated with electromagnetic waves of terahertz range. Use frequencies of molecular spectrum of radiation and absorption of nitrogen oxide of 150.176-150.664 GHz, power density of 0.2 mW/cm2. An irradiation is spent within 30 minutes. EFFECT: production normalisation of nitrogen oxide, endothelium function at post-stress conditions. 1 tbl
The invention relates to medicine, particularly cardiology, and can be used to restore the reduced production of nitrite in blood plasma of cardiac patients. Endothelial dysfunction is the initial step in the pathogenesis of various diseases of the cardiovascular system such as hypertension, atherosclerosis, coronary heart disease: stable and unstable angina [Stokes CO Granger D.N. The microcirculation: a motor for the systemic inflammatory response and large vessel disease induced by hypercholestcrolaemia? // J Physiol. - 2004. - V.562 No. 3. - P.647-653.]. Endothelial dysfunction is accompanied by a drop in the production of vasodilatory and anti-platelet agents and prevalence of vasoconstrictor and prothrombogenic factors that leads to increased vascular tone and provokes the development of thrombosis. One of the most important factors released by the endothelium is nitric oxide [Ignarro L.G., Murad F. Nitric oxide: biochemistry, molecular biology and therapeutic Memorandum. // Adv. Pharmacol. - 1995. - V.34. - P.1-516.]. In addition, nitric oxide regulates the production of other biologically active substances, in particular of prostacyclin [J.P.J. Halcox, Nour K.R.A., Zalos G, Quyumi A.A. Coronary vasodilatation-and improvement in endothelial dysfunction with endothelin ETA receptor blockade. // Circ. Res. - 2001. - V.89. - P.969-976]. Endogenous nitric oxide exists and is continuously synthesized in organs, tissues and cells by enzymatic with the participation of NO-synthase - th is VA of cytochrome P-450-like enzymes, using as substrate the amino acid L-arginine. Formed in the body nitric oxide, oxidized, goes into nitrites and then into nitrates [Karpyuk V.B. have been, Chernyak US, Subic MG Laboratory monitoring nitroxidergic vasorelaxation after subarachnoid hemorrhage. // Clinical and laboratory diagnosis - 2000. No. 5. - P.16-19.]. It is proved that in patients already at the initial stages of development of diseases of the cardiovascular system is the reduction of nitric oxide by the endothelium, which leads to reduced concentration in the blood plasma of its stable metabolites nitrite and nitrate [manukhina E.B., Lyamin, NP, Zolotovsky PV, Lyamin S. Role of nitric oxide and oxygen free radicals in the pathogenesis of hypertension. // Cardiology. - 2002. No. 11. - P.34-7.]. One of the most important etiological factors leading to the development of diseases of the cardiovascular system, is stress. Excessive strength or duration of the stress response leads to the development of disorders that gives rise to a number of diseases [Meyerson FS Adaptation, stress, and prevention /. M.: Nauka, 1981. - 425 S.]. Currently grounded insight generation of nitric oxide as a separate stress-limiting system. It is activated when the effect on the body's stress f is Ktorov and in the process of adaptation to the repeated impacts of environmental factors [Malyshev YOU, Manukhina E.B. Stress, adaptation and nitric oxide. // Biochemistry. - 1998. - T. No. 7. - S-1006.; Manukhina E.B., Malyshev YOU Stress-limiting system of nitric oxide. // Ross. Fiziol. log them. Sechenov. - 2000. - T. No. .10. - S-1292.]. Increased nitric oxide production is usually observed when the effect of short-term stressors and, apparently, corresponds to the stage of mobilization with adequate stress response. The decrease in NO production occurs when prolonged and severe stress and corresponds to the stage of exhaustion when excessive stress reactions [Malyshev YOU, manukhina E.B. Stress, adaptation and nitric oxide. // Biochemistry. - 1998. - T. No. 7. - S-1006.; Manukhina E.B., Malyshev YOU Stress-limiting system of the nitric oxide // Ross. Fiziol. log them. Sechenov. - 2000. - T. No. .10. - S-1292]. Research and development of control methods of synthesis, to maintain the physiological level of concentration and functional status of endogenous nitric oxide in cells, organs and the organism as a whole is of great scientific and practical interest. Currently known methods of correction of nitric oxide production by group of drugs donor of nitric oxide. However, pharmacological regulation of NO synthesis in vivo may be accompanied by unwanted and sometimes harmful side effects is impressive. Clinical applications of organic nitrates as a donor of nitric oxide is accompanied by the development of tolerance and cross-tolerance also may contribute to endothelial dysfunction, further reducing the production of nitric oxide by the endothelium [Münzel So, Daiber, A., Mülsch A. Explaining the Phenomenon of Nitrate Tolerance. // AHA Circulation Research. - 2005. - V.97. - P.618-645.]. This necessitates a survey of non-invasive physical controllers synthesis of endogenous nitric oxide on the basis of natural physiological regulation. To assess endogenous synthesis of nitric oxide along with direct measurement of NOS activity (education citruline) use concentration of stable metabolites nitrite and nitrate. The concentration of nitrite is an objective criterion activity nitroxidergic system [Karpyuk V.B. have been, Chernyak US, Subic MG Laboratory monitoring nitroxidergic vasorelaxation after subarachnoid hemorrhage. // Clinical and laboratory diagnosis - 2000. No. 5 - P.16-19.]. Our first proposed method of recovery of low concentrations of nitrite in plasma under conditions of stress, including exposure to animals electromagnetic waves with a power of 0.7 mW (power density flux of 0.2 mW/cm2) at frequencies of molecular spectrum of emission and absorption of oxide AZ is the 150,176-150,664 GHz for 30 minutes Was to study serum samples blood 80 white nonlinear of male rats weighing 180-220 g As a model of acute stress, we used a rigid fixation on the back within 3 hours [Kirichuk V.F., Ivanov A.N., Antipova OLGA, Krenicki A.P., it was found A.V., Tupikin E, Betsky OV Influence of EHF-radiation on the function of platelets and red blood cells white rats under stress. // Cytology - 2005. - T (1). - P.64-70.]. Irradiation of animals THZ-waves at frequencies SIP of nitric oxide 150,176-150,664 GHz was conducted by generator "EHF-NO", developed in the Medico-technical Association of EHF (Moscow) in cooperation with the Federal state unitary enterprise "SPE-Source" (Grazyna) and OJSC extremely high frequencies stimulated (Saratov) [Betsky OV, Krenicki A.P., it was found A.V., Tupikin E Apparatus for the treatment of waves of extremely high frequency. // RF patent for useful model №50835 from 27.01.2006]. Was irradiated skin surface area of 3 cm2above the xiphoid process of the sternum. The irradiator was located at a distance of 1.5 cm above the surface of the body of the animal. The radiation power of the generator was equal to 0.7 mW, and the power density incident on the area of skin the size of 3 cm2was 0.2 mW/cm2. The exposure dose was determined by the power density incident on the skin, and the total irradiation time. Single irradiation of animals in a state of acute stress was conducted in accordance with the ie 30 minutes. Blood sampling was carried out by puncture of the right departments of heart. Determining the concentration of nitrite in plasma was performed using reagent Griss [Kartok V.B. have been, Chernyak US, Subic MG Laboratory monitoring nitroxidergic vasorelaxation after subarachnoid hemorrhage. // Clinical and laboratory diagnosis - 2000. No. 5 - P.16-19.]. The study was conducted on 3 groups of animals: group 1 - control, consisted of 20 intact animals; 2nd group - comparative, contained 28 of male rats in a state of acute immobilization stress; 3rd group - experienced, included 32 animals subjected to the THZ-radiation at frequencies of molecular spectrum of emission and absorption of nitric oxide 150,176-150,664 GHz. All animals were housed under identical conditions. In control groups and comparison was carried out the same manipulations associated with irradiation, as in animals experienced group. Experiments on animals were conducted in accordance with the requirements of the Geneva Convention "International Guiding Principles for Biomedical Research Involving Animals" (Geneva, 1990). Statistical data processing was performed using the program Statistica 6.0. Tested hypotheses about the form of the distributions (criterion Shapiro-Wilks). Most of our data are not inconsistent with a normal distribution, therefore, to compare the values of ispolzovalsya U-test Mann-Whitney. As a result of the research found that of male rats subjected to 3-hour immobilization, is a statistically significant decrease in the concentration of nitrite in plasma (table). This indicates the decrease in the concentration of nitric oxide in the blood plasma of male rats in a state of immobilization stress. It is established that exposure of white rats-males in a state of immobilization stress, electromagnetic waves in the terahertz range of frequencies of molecular spectrum of emission and absorption of nitric oxide leads to increased concentrations of nitrite in blood plasma (table). However, it should be noted that the range of variability of the concentration of nitrites in animals subjected to irradiation of THz waves on the background of immobilization stress significantly wider variability of this indicator in animals of the control group (table). As examples of the data 3 of male rats weighing 200, 210 and 190 g, respectively. The first one is not subjected to any stress control, the second was in a state of acute immobilization stress (3-hour immobilization) and the third is subjected to 30-min THZ-radiation on the background of acute immobilization stress. Concentration in the serum of the first animal was 0,500 mg/ml, the second LM is now - of 0.333 mg/ml and the third - 0,444 µg/ml. Thus, for the first time established that electromagnetic terahertz radiation at frequencies of molecular spectrum of nitric oxide 150,176-150,664 GHz capable to recover low concentrations of nitrite in plasma under conditions of stress, which indirectly indicates the normalization of nitric oxide production and allows to normalize endothelial function at poststressornah States. In addition, the proposed method it is possible to extrapolate to patients for the treatment of several diseases associated with reduced nitric oxide production, and hence the concentration of stable metabolites nitrite (arterial hypertension, ischemic heart disease: stable and unstable angina and other diseases of the cardiovascular system).
Method of recovering low concentration of nitrite in plasma under conditions of stress, namely, that the area of the xiphoid process of the sternum white rats in a state of acute immobilization stress, is irradiated with electromagnetic waves in the terahertz range of frequencies of molecular spectrum of emission and absorption of nitric oxide 150,176-150,664 GHz power density of 0.2 mW/cm2within 30 minutes
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