Therapy of vertebrobasilar insufficiency

FIELD: medicine.

SUBSTANCE: invention refers to medicine, to neurology. The therapy involves taking the medicines improving cerebral blood circulations. Pharmacotherapy is combined with exposure to laser light within anconeus and popliteal fold regions. Laser puncture covers the points VB 20 and VB 21 symmetrically downright. Laser light is characterised with wavelength 0.89 mcm, power 3 mW and frequency 600 Hz. Herewith light exposure is 1 minute per each point and 2-3 minutes per elbow and popliteal folds. Therapeutic course is 10 days twice every second month.

EFFECT: method reduces treatment time.

3 ex, 1 tbl

 

The invention relates to medicine, in particular, neurology, and can be used for the treatment of vertebrobasilar insufficiency.

Vertebrobasilar insufficiency (VBN) is reversible brain dysfunction caused by reduced blood supply to the area, fed by vertebrates and major arteries. VBN is often a harbinger of severe cerebral strokes in the stem part and the cerebellum, the presence of transient ischemic attacks increases the risk of stroke in 6 times.

Prolonged hypokinesia leads to morphological changes in the vertebral arteries that causes the greatest production trucapture associated with frequent and prolonged exacerbations of the disease with a tendency to chronicity.

Early diagnosis and timely treatment of patients at the stage of transient ischemia of the brain and comprehensive preventive treatment in interictal period reduces the risk of heart attack the rear of the brain, and can push the development of ischemic stroke for many years and even decades.

There are ways of treatment of vertebrobasilar insufficiency, for example surgical treatment, but they are shown only a small proportion of patients with vertebrobasilar insufficiency. Surgical methods only remove nedostate the activity of the circulation, associated with decreasing diameter of the vertebral artery, resulting from stenosis, compression.

There are medical methods of treatment, including drugs, improves cerebral blood flow, metabolism vascular wall and improve its anti-platelet properties. While preference is given to drugs with a complex mechanism of action, affecting vascular, metabolic and neurotransmitter processes through the ischemic brain. Among such tools, which are able to restore blood flow, microcirculation, improve the metabolism of brain tissue, to protect neurons from ischemic hypoxia include, for example, Cavinton, trental, Actovegin, nootropil, gliatilin.

But the disadvantages of medical treatment methods are:

- the long duration of the treatment;

- the possibility of allergic reactions;

- side effects of drugs and intolerance to certain drugs, expressed in systemic blood pressure lowering, the development of tachycardia, diarrhoea symptoms, drowsiness, dizziness, weakness, impaired liver and kidney and other)

- invasiveness, as in acute need arises for the administration of drugs parenteral (Zhulev NM, Kandyba D.V. Yakovlev NA "Cervical osteoporos. Vertebral artery syndrome. Vertebral-Basilio is Naya failure. - SPb.: Publishing house "LAN", 2002. - 460-553 C.)

Close the analog prototype is the effect of helium-neon laser and infrared laser radiation on the reflex zones of the face, the projection of the vertebral artery and the cubital vein depending on the source of the autonomic tone of the cardiovascular system a wavelength of 890 nm, a frequency of 150 Hz, the power of 3 W (patent No. 2180207). The disadvantages of this method of treatment is the complexity of the effects of two kinds of laser radiation and the need to identify the source of the autonomic tone of the cardiovascular system.

The objective is to propose a method for the treatment of vertebrobasilar insufficiency.

The technical result - the simplification of the treatment of vertebrobasilar insufficiency, by using only one laser - infrared, without additional examinations of the cardiovascular system.

The technical result is achieved by the fact that in addition to medical treatment, namely, Cavinton, improves cerebral circulation, appoint percutaneous exposure to blood in the cubital and popliteal folds, so as to irradiate the blood leads to the activation of antioxidant radical scavenging the body's defence system, implemented in the pathogenetic processes of the brain, described in the table, with the help of the device "In the PR-AND-2K" with a wavelength of 0.89 microns, the power of 3 W, mode radiation pulse 110 NS, with a frequency of 600 Hz, as this is the frequency that leads to the harmonization of energy in the acupuncture points. Also affect acupuncture symmetric point of the gall bladder channel VB 20 underneath the occipital bone above the rear boundaries of hair growth by 1.5 cm hole at the outer edge of the trapezius muscle, and VB 21, located at mid-distance from the midline of the back at the level of the space between the spinous processes of C7-D1 vertebrae to tuberosity of the humerus, as the effect on these points helps to relax the muscles of the shoulder girdle, which reduces the compression of the neck vessels and improves cerebral circulation. The sequence of the exposure down on the symmetric region. Exposure time exposure: 1 minute on the acupuncture point, for 2-3 minutes on the cubital and popliteal fossa. The course of treatment is 10 days. Spend 2 treatment with a break for a month.

The advantages of the proposed method:

- reduced the number of drugs,

- reduction in disability days;

the method is pathogenic, stimulating endogenous antioxidant antiradical protection of the body and suppressing the generation of highly reactive toxic oxygen metabolites radical and non-radical nature minimizes disturbance of systemlog the free radical status;

the method is non-invasive, painless,

- prevents the pathogenetic progression of irreversible processes in the brain, induced toxic species of active oxygen metabolites

good tolerability;

The integral assessment of the processes of biogenesis of active oxygen metabolites, including free radical oxidation, used chemiluminescence method (CML). Registration has been carried out on the luminescence spectrometer LS-50B "PERKIN ELMER". Standardization of the signal and mathematical processing of the curves was performed using the program "Finlab". Defined: sutasoma for 1 min spontaneous CML, the value of which correlates with the intensity of generation of active oxygen metabolites; maximum fast flash-induced CML, indicating the content of lipid hydroperoxides, sutasoma for 2 minutes after the "fast" flash, reflecting the rate of peroxide radicals lipid nature. The kinetics of CML, initiated by N2About2in the presence of lyuminola, were analyzed by two parameters: a) maximum glow, the amplitude of which is directly proportional to the potential of a biological object to peroxide oxidation and inversely proportional to the functional activity of catalase; b) sitesome for 2 min CML, the value of which clicks the IDT is proportional to the antiradical activity of antioxidant protection. The intensity of chemiluminescence, measured in millivolts, was calculated from 1 ml of serum and expressed in relative units. The data are processed statistically using t-student test.

Analysis of the CML indicators demonstrated, see the table that in the serum of patients with the syndrome vertebrobasilar insufficiency after applying the laser puncture was observed activation of antioxidant antiradical protection system as a whole and increase resistance to peroxide oxidation, in particular.

Increased activity of detoxication systems after laserpuncture, respectively, lead to an adequate response from the opposite component of the free radical status, oppression of the processes of generation of active oxygen metabolites. Thus, our findings CML analysis of the dynamics of indicators of systemic free radical status of patients with the syndrome vertebrobasilar insufficiency suggest that the use of laser puncture in the complex treatment of this pathology pathogenetically reasonable and efficient.

Example 1

Patient K., 42 years old, with diagnosis of Dispute. The defeat of the vertebral motor segment C4-7, chronic, decompensation syndrome cervicalgia and vertebrobasilar defects in the accuracy. Complaints to intermittent pain in the neck, dizziness, weakness, decreased performance, anxiety and fear.

Ill for five years. The recent deterioration of health within one week after emotional stress. On radiography of the cervical spine instability at C4-5.

On REG: source increased tonus of arteries: the pool of the internal carotid artery 87%, vertebrobasilar pool 91%. Obstruction of the venous outflow 52%. The index of the spectral expansion of the blood flow in the vertebral artery after positional samples 55%.

CML-analysis of serum: the intensity of generation of active oxygen metabolites 0,107 oted, the concentration of lipid hydroperoxides 0,129 oted, the rate of formation and accumulation of peroxide radicals lipid nature 0,370 oted, peroxide resistance 0,192 oted, the antiradical activity of antioxidant protection 0,211 oted

The patient is assigned Cavinton in the dose of 5 mg 2 times a day and 10 sessions of laser puncture in the proposed method: puncture device Pattern-AND-2K" on the elbow and knee creases, the wavelength of 0.89 μm, the power of 3 W, a frequency of 600 Hz. Additional impact on the acupuncture points of the gall bladder channel VB 20 and VB 21 symmetrically. The sequence of the exposure down on the symmetric region. Exposure region is ing: 1 minute on the acupuncture point, for 2-3 minutes on cubital and popliteal fossa.

After the treatment: condition after treatment has improved significantly: in three days the pain disappeared in the neck, increased efficiency, decreased significantly dizziness, improved mood.

on REG: reduced initial increased tonus of arteries: the pool of the internal carotid artery 72%, vertebrobasilar pool 85%. Reducing the difficulty of venous outflow of 32%. The index of the spectral expansion of the blood flow in the vertebral artery after positional samples 37%.

CML-analysis of serum: a lower rate of generation of active oxygen metabolites to 0,065 oted, the decrease in the concentration of lipid hydroperoxides to 0,088 oted, reducing the rate of formation and accumulation of peroxide radicals lipid nature to 0,142 oted, the increase in peroxide resistance to 0,112 Rel. units, increasing the activity of antioxidant antiradical protection to 0,120 oted

Example 2

Patient M., 54 years old, with diagnosis of Dispute. The defeat of the vertebral motor segment C4-5, chronic, decompensation syndrome vertebrobasilar insufficiency.

Complaints about headaches arching nature, dizziness, flashing "flies" before the eyes, fatigue, loss of memory.

Ill for ten years. Notes seasonal deterioration sa is acestuia (autumn, spring).

On REG: source increased tonus of arteries: the pool of the internal carotid artery 89%, vertebrobasilar pool 92%. Otradnoye venous outflow 55%. The index of the spectral expansion of the blood flow in the vertebral artery after positional samples 62%.

CML-analysis of serum: the intensity of generation of active oxygen metabolites 0,134 oted, the concentration of lipid hydroperoxides 0,161 oted, the rate of formation and accumulation of peroxide radicals lipid nature 0,435 oted, peroxide resistance 0, 228 oted, the antiradical activity of antioxidant protection 0,275 oted

The patient is assigned Cavinton in the dose of 5 mg 2 times a day and 10 sessions of laser puncture in the proposed method: puncture device Pattern-AND-2K" on the elbow and knee creases, the wavelength of 0.89 μm, the power of 3 W, a frequency of 600 Hz. Additional impact on the acupuncture points of the gall bladder channel VB 20 and VB 21 symmetrically. The sequence of the exposure down on the symmetric region. Exposure time exposure: 1 minute on the acupuncture point, for 2-3 minutes on the cubital and popliteal fossa.

7 days after treatment, the condition has improved considerably: the headaches disappeared, dizziness decreased significantly improved processes of remembering.

on REG: reduced initial increased tonus of arteries: a swimming pool is the internal carotid artery 69%, vertebrobasilar pool 95%. Reducing the difficulty of venous outflow 34%. The index of the spectral expansion of the blood flow in the vertebral artery after positional samples 37%.

CML-analysis of serum: a lower rate of generation of active oxygen metabolites to 0,077 oted, the decrease in the concentration of lipid hydroperoxides to 0,090 oted, reducing the rate of formation and accumulation of peroxide radicals lipid nature to 0,165 oted, the increase in peroxide resistance to 0,141 oted, increase the activity of antioxidant antiradical protection to 0,150 oted

Example 3

Patient T., 35 years old, with diagnosis: Disapate. The defeat of the vertebral motor segment C2-4, chronic, decompensation syndrome vertebrobasilar insufficiency.

Complaints of hearing loss, tinnitus, increased from turning their heads, feeling of heaviness in the head, unsteady gait. Ill for years.

On REG: source increased tonus of arteries: the pool of the internal carotid artery 85%, vertebrobasilar pool 88%. Otradnoye venous outflow 57%. The index of the spectral expansion of the blood flow in the vertebral artery after positional samples 55%.

CML-analysis of serum: the intensity of generation of active oxygen metabolites 0,098 oted, the concentration of lipid hydroperoxides 0,110 oted, SKO is the spine formation and accumulation of peroxide radicals lipid nature 0,302 oted, the peroxide resistance rate £ 0.162 oted, the antiradical activity of antioxidant protection 0,189 oted

The patient is assigned Cavinton in the dose of 5 mg 2 times a day and 10 sessions of laser puncture in the proposed method: puncture device Pattern-AND-2K" on the elbow and knee creases, the wavelength of 0.89 μm, the power of 3 W, a frequency of 600 Hz. Additional impact on the acupuncture points of the gall bladder channel VB 20 and VB 21 symmetrically. The sequence of the exposure down on the symmetric region. Exposure time exposure: 1 minute on the acupuncture point, for 2-3 minutes on the cubital and popliteal fossa.

After the treatment: condition after treatment significantly improved after 5 days significantly decreased the noise in the ears, improved hearing, improved coordination of movements.

On REG: reduced initial increased tonus of arteries: the pool of the internal carotid artery 69%, vertebrobasilar pool 80%. Reducing the difficulty of venous outflow of 32%. The index of the spectral expansion of the blood flow in the vertebral artery after positional samples 32%. Decreased the dependence of the blood supply of the vertebral artery from the turn of the head,

CML-analysis of serum: a lower rate of generation of active oxygen metabolites up to 0.060 oted, reducing the concentration of lipid hydroperoxides to 0,079 oted, speed reduction education the project and accumulation of peroxide radicals lipid nature to 0.135 oted, the increase in peroxide resistance to 0,085 oted, increase the activity of antioxidant antiradical protection to 0,103 oted

Clinical and laboratory evaluation of the effectiveness of laserpuncture in complex therapy of vertebral-basilar insufficiency
No.Pathogenetic processes in the brain according to the CMLMedicines and laserpuncture n=30Medication n=30
1.The decrease in the intensity of generation of active oxygen complexes0,068 atmospheric air0,125 atmospheric air
2.The decrease in the concentration of lipid hydroperoxidesof 0.081 atmospheric air0,140 oted
3.The slow processes of formation and accumulation of peroxide radicals lipid nature0,136 atmospheric air0,380 oted
4.Increase resistance to peroxide oxidation0,10 oted 0,190 atmospheric air
5.The increased activity of the antioxidant defense0,122 atmospheric air0,230 atmospheric air
6.According to REG reducing the initial high tone of arteries
The pool of the internal carotid artery at the rate of 55-70%70%89%
Vertebrobasilar the pool at a rate of 60-75%85%91%
7.Improving venous outflow at the rate of 5-20%32%52%
8.The reduction of the index of the spectral expansion of the blood flow in the vertebral artery after positional sample37%52%
n - number of patients
CML chemiluminescent analysis of blood serum
REG rheovasography of vessels in the brain

A method for the treatment of vertebrobasilar insufficiency, including the administration of medications that improve blood circulation of the brain, characterized in that it further designate the puncture in the cubital and popliteal folds with a wavelength of 0.89 microns, with a capacity of 3 mW, a frequency of 600 Hz, and the point of the gall bladder channel VB 20 and VB 21 is symmetrical from top to bottom, while the exposure time is 1 min on each point of the gall bladder channel and 2-3 minutes on the elbow and knee creases, treatment twice for 10 days with a break between courses of one month.



 

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