Method of treating chronic generalised parodontitis
SUBSTANCE: invention relates to medicine, namely to stomatology, and can be used for treatment of chronic generalised periodontitis. For this purpose cryotherapy is applied on ulnar artery nerve plexus, by exposing ulnar artery in lower part of foream and placing cryoapplicator on it. Application duration is 10 s at temperature -186°C. After that detralex is administered in dose 1 tablet 2 times a day for 2 weeks, then for two weeks: grandaxin 1 tablet in the morning, spasgan 1 tablet in the afternoon and atarax 1/2 tablet before going to bed.
EFFECT: increase of treatment efficiency; increase of disease remission terms due to improvement of peripheral blood circulation at the background of compensation of patient's vegetative profile.
The invention relates to dentistry and can be used for the treatment of patients with chronic generalized periodontitis.
Traditional approaches to the treatment of this disease consist in the use of local applications of drugs or surgical methods to reduce the severity of the pathological process (Beck JD, Slade G, Ofrenbacher S. Oral disease, cardiovascular disease and systemic inflammation. Calls 2000; 23:110-120) /1/. This local approach with a large number of unsatisfactory results and the progression of the disease in 52-76% of patients.
Meanwhile, at the present time it is established that chronic periodontitis is a multifactorial disease, in its development in humans have not identified any simple, direct connection "pathogenic factor - disease", which complicates the search for optimal methods of treatment. As one of the factors in the development of periodontitis consider the result of a complex interaction of infectious agents (bacteria) and the immune system of the host, which is often regulated by environmental factors and behavioral characteristics. It is proved, in particular, that on the progression of periodontitis affected by demographic, environmental and biological factors.
Advanced age and the presence of gingivitis are established risk factors is the development of periodontitis. In addition, severe periodontitis significantly associated with risk factors such as male gender, presence of dental calculus, low level of education and oral hygiene and the presence of diabetes.
In the light of recent research a key role in the development of periodontitis divert the immune reactivity of the host, namely such violations in the immune inflammatory response, leading to the destruction of periodontal tissues. Genetic factors probably play a role in the development and progression of periodontitis. It is shown that many of genetically determined disorders of leukocyte adhesion and changes in the Fc-fragment specific leukocytes, as well as metabolic changes leading to impaired bone formation, contribute to the development and rapid progression of periodontitis. According to Japanese researchers, genetic polymorphism of inflammatory mediators and structural proteins of the connective tissue of the periodontium determines the speed and character of the course of pathological processes in periodontitis.
Russian researchers have shown that in the development of generalized periodontitis and related diseases of internal organs play a pathogenetic role violations of peroxide oxidation of lipids, proteins and low molecular weight thiols, and immunologica the cue imbalance and shortage of basic macro - and micronutrients (CA, Mg, K, Na, Zn, Cu, Fe).
Found a significant Association between chronic periodontitis and systemic disease such as atherosclerosis, ischemic heart disease and chronic lung disease. It is also shown that the presence of periodontitis in the past 10 years significantly increases the risk of developing disorders of glucose tolerance with subsequent increased risk of diabetes mellitus type II.
Thus, at the present time practically no doubt that the development and progression of chronic periodontitis play a role as a system component, and the presence of periodontal disease as a chronic inflammation was noted with the system response is a risk factor for other diseases, the pathogenesis of which a systemic inflammatory response plays an adverse role.
There is a method of treatment of chronic generalized periodontitis mild and moderate severity (Patent RU 2248785, publ g) /2/. The known method includes EHF-therapy, which consists of electromagnetic radiation of extremely high frequency on periodontal tissues and biologically active points (BAP) for 20 minutes at 6-7 sessions daily in the treatment of diseases of slight severity and 7-9 sessions in the treatment of periodontitis of moderate severity. This EHF-therapy on the background of medical therap and, involving drugs "Biovita calcium and Complivit" standard schemas.
The result achieved in a known manner, consists in relieving the symptoms of inflammation and normalization of local circulation in the periodontal tissues through physical therapy effects on inflamed periodontal tissues against medical and reflex effects on the body. This approach to treatment can also be attributed to local, it affects the result and not the cause of the disease, and therefore cannot give long-term effect.
The authors have not revealed information about the medical treatment of periodontal disease, taking into account the influence of the system component in the development and progression of this disease.
The present invention is directed to establish such a method of treatment of chronic generalized periodontitis, which would help to compensate for the more complex factors that lead to inflammation and poor circulation in the tissues.
The invention is based on accumulated during the last decade of data that the sympathetic part of the ANS innervates all lymphoid organs, and that the catecholamines are the main mediators of the sympathetic ANS is able to influence some parameters of immunity. It is shown that, firstly, all of the Central and peripheral organs of the immune system have R is switow network noradrenergic nerve endings, and, secondly, all immune cells have receptors for norepinephrine as circulating and secreted locally from asinapticheskikh branches of nerve fibers. Thus, the sympathetic nervous system provides a direct and explicit link between the brain and the immune system.
Currently, it is revealed that the catecholamines, as well as corticosteroids, in certain concentrations and under certain conditions can provide not only immune, but a variety of (often mixed) immunomodulatory effect. Study characteristics influence neuroendocrine influences on the immune response allows a clearer picture of the pathogenesis of many pathological conditions, such as infectious diseases, autoimmune and inflammatory reactions, allergic and neoplastic diseases.
The authors of the present invention require the presence of such interactions in the pathogenesis of periodontitis. In the periodontal tissues may occur functional voltage exceeding physiological, which to a certain extent be compensated by appropriate tissue and vascular reactions of periodontal (compensated functional overload). During its progression opportunities vascular system that supports the appropriate level of metabolism in the tissue is s, exhausted and decompensation occurs.
A leading role in the mechanism of development of dystrophic changes of the periodontium in traumatic occlusion is attached to circulatory disorders. Such changes occur when expressed hesitation functional load. Changes in vascular aging and various diseases also lead to the violation of cushioning and trophic function of the periodontium. In addition, there is excessive stretching of the fibers of the periodontal disease, and congestive changes in the microcirculation system, accompanied by acidosis.
The claimed invention is to eliminate changes in the balance of sympathetic and parasympathetic parts of the autonomic nervous system. Restored balance will cause the autonomic nervous system will be able to determine the nature of the microcirculation, including the seat of chronic inflammation, and modulate immune response. This explanation now seems very likely, since practice has shown that the effects on the autonomic nervous system has a positive effect on the course of periodontitis.
The invention consists in the application of cryotherapy on the nerve plexus ulnar artery duration appliques 10 seconds, the number of cycles 2, at a temperature of -186°C and the subsequent drug is ecene two courses. The first course produced after cryotherapy for two weeks drugs "Detralex" 1 tablet 2 times a day and Nikoshpan 1 tablet 3 times a day. The second course is produced within two weeks drugs "Grandaxin" 1 tablet in the morning, "Sashan" 1 tablet in the afternoon and "Atarax" 1/2 pill at night. The first course of treatment drugs can improve venous blood flow and improve blood flow, the second is to accelerate the payment of the autonomic profile of the nervous system.
In this case, the cryogenic nervous plexus ulnar artery carry out compensation of the autonomic profile of the patient, and using certain way chosen complex drug therapy, carried out within 2 weeks, accelerate treatment time, getting earlier and lasting results.
Thus, a new technical result achieved by the claimed invention is an accelerated improvement of peripheral blood flow on the background of the compensation vegetative patient profile that allows you to achieve better results of treatment of patients with chronic generalized periodontitis, to extend periods of remission, favorably influence the course of comorbidities. In addition, compared with the method /2/ claimed method is more comfortable for the patient is well, since the duration of cryotherapy for 10 seconds in two cycles at one time differs significantly from 20 minutes for 6-9 cycles. Medication takes half the time than in the known method /2/. Equipment for carrying out the treatment is easier and cheaper than devices for EHF-therapy.
Patient Dmitriev, 40 years, complaints about the presence of bleeding gums, sore mouth, loss of teeth within 2 years, the inefficiency of conservative treatment medical therapy. When examination revealed signs of generalized periodontitis.
The condition is satisfactory HELL 130/90, P 80 beats per minute, diseases of the cardiovascular system, internal organs not. If rheoencephalography signs subcompensation peripheral blood flow EN=2,7-3,2, KA=2.5 and α=71-73°. Preparation for surgery traditional. Under local anesthesia Sol. lidocaini 2%-2.0 dissect the skin projection of the ulnar artery in the lower third of the forearm for 1 cm, then install miniature allow that using videoassistance techniques in layers extend deep into the wound, making the dissection of soft tissues. Soft tissue gradually divert the retractor of they, exposing the ulnar artery. The tip of cryoapplicator a diameter of 2 mm are installed on Nude artery, p is izvodyat cryogenic duration appliques 10 seconds the number of cycles 2, at a temperature of -186°C. Then cryoapplicator warm and remove from the wound, the edges of which suture.
After cryotherapy provide medical treatment of a patient with two courses. The first course in the two weeks drugs "Detralex" 1 tablet 2 times a day and Nikoshpan 1 tablet 3 times a day. The second course in the two weeks drugs "Grandaxin" 1 tablet in the morning, "Sashan" 1 tablet in the afternoon and "Atarax" 1/2 pill at night.
In the period after the intervention for cryotherapy pain relief was required during the first days, bed rest is not required, the sutures were removed on the fourteenth day. Complications of surgery were noted. At check in 1.3 months showed signs of compensation of chronic periodontitis, peripheral blood flow, autonomic profile, the patient no complaints. In this way treated 50 patients, complications were not observed.
The claimed method of treatment of patients with chronic generalized periodontitis allows to achieve better results of treatment, to prolong the period of remission of the disease, to have a beneficial effect on the course of diseases and, in particular hypertension. Especially important is that this method of treatment gives a very persistent put the preliminary results in the group of patients previously long and unsuccessfully treated with other methods.
The method of treatment of chronic generalized periodontitis, characterized in that operate at cryogenic nerve plexus ulnar artery by exposure of the ulnar artery in the lower third of the forearm and installation of cryoapplicator with length appliques 10 s at a temperature of -186°C, followed by drug treatment two courses of a duration of two weeks: first course - Detralex - 1 tablet 2 times a day, nikoshpana - 1 tablet 3 times a day; second course-grandaxin - 1 tablet in the morning, sashan - 1 tablet day atarax - 1/2 pill at night.
SUBSTANCE: invention concerns pharmaceutical industry, in particular, an agent for prevention of teeth caries. The tooth elixir for prevention of teeth caries, containing fluoride of sodium, glycerin, infusion of a labrador tea marsh, creeping myrtle, peppermint, tillet, and also Kislovodskaya Celebnaya mineral water, taken in a certain ratio.
EFFECT: above described tooth elixir is effective for prevention of teeth caries.
1 tbl, 1 ex
SUBSTANCE: invention concerns medicine area, namely, stomatology and concerns agents of local application for treatment of stomatologic diseases. The invention represents a probiotic mean in the form of the ointment, containing bacteria of sort Bifidobacterium and Lactobacillus forming a conglomerate with a pharmaceutically comprehensible sorbent, an adhesive component, surface-active substance, and as fat oils of a phytogenesis or Solutioes oleosa of vitamins.
EFFECT: inventions preventing of development of pathogenic microflora in a mouth, stopping inflammatory processes, rendering, thus, the expressed medical action, excepting by-effects and increasing of the efficiency of treatment of inflammatory stomatologic diseases and carrising out in the medicinal form simple and convenient for application.
7 cl, 7 ex
SUBSTANCE: invention concerns dentistry, particularly oral compositions containing moistening agent and/or abrasive compound and effective antibacterial quantity of compound of the formula (I). In different version of implementation, the composition includes approximately 0.001 to 10 wt % of compound of the formula (I).
EFFECT: antibacterial effect, prevention of dental deposit formation in oral cavity.
11 cl, 2 ex, 1 tbl
FIELD: medicine; dentistry.
SUBSTANCE: treatment of inferior dental nerve neuritis caused by filling material delivery into mandibular canal is ensured with introduction of antibacterial agent before operation. Thereafter filling material is surgically removed from mandibular canal. Operation procedure is followed with introduction of antibacterial and immune correcting agents, antisensitisers, Reaferone, vitamins B1 and B12, adenosine triphosphate. Besides mandibular region is exposure to laser magnetotherapy with using dental apparatus Optodan, accompanied with intraoral HBO-therapy, hydromassage, hydrocortisone phonophoresis, 2% nicotinic acid solution amplipulse phoresis, Tambukan mud therapy, pine needle and pearl baths, acupuncture with using local and regional points.
EFFECT: higher treatment efficiency, restored blood circulation, accelerated rehabilitation, complete relief of evident pain syndrome and post-amputation pains, simplicity, efficiency.
SUBSTANCE: traditional treatment includes operative intervention with additionally detected phase of menstrual cycle for women of childbearing age. In case disease is developed in late folliculin phase, Clopidogrel is introduced orally in single dose 75 mg in the day of operation. Then alveolar process from vestibule of mouth cavity is covered with bolsters impregnated with 0.2% 5-oxy 4-methyluracyl in 10% dimethylsulphoxide within 15-20 minutes up to 5 times a day. And since the second day after operation phonophoresis method is applied daily in amount 10-20 ml within 5-7 minutes during 5 days.
EFFECT: provides improved rheological and coagulation properties of blood, correction of oral immunity that is accompanied with reduction of inflammatory process and short-term tissue regeneration after surgical intervention.
FIELD: medicine; stomatology.
SUBSTANCE: on a vestibular surface of gum mucosa in the field of the damaged site or if the lesion is generalised - that in the field of roots of 4 or 5 teeth of a corresponding jaw fix size of amplitude of the electromagnetic fluctuations induced in a tissue by external natural electromagnetic fields (EMF) as a result of its bioelectric activity. According to amplitude, form initial parametres of a low-frequency impulsive complex of modulated electromagnetic field (CM EMF). Form the field with parametres: frequency of modulation in a range from 0.3 to 0.8 Hz, frequency of following of impulses in a range from 3 to 30 Hz, with width of a spectrum of harmonious components in a range from 500 Hz to 1 kHz, size of an induction of a magnetic field from 8 to 12 mT. Apply by means of applications a medical product on a surface of a gum mucosa from the oral and vestibular sides and a normal saline solution on a surface of teeth. As a medical product, use a composition prepared on a basis organosilicone glycerogel and containing chlorhexidine, metronidazole, pefloxacin at a following parity of masses, %: chlorhexidine - from 0.001 to 0.2; metronidazole - from 1.0 to 1.5; pefloxacin - from 1.0 to 1.5; organosilicone glycerogel - the rest. Influence CM EMF simultaneously on the parodontium tissues and on a spine column. In the course of influence constantly supervise size of amplitude of electromagnetic fluctuations and change size of CM EMF by a feedback principle.
EFFECT: deep penetration of a medical product into area of locomotive structures of teeth and creation of depot of a pharmacological preparation of the necessary concentration, the expressed local antiinflammatory, antiedematous and antibacterial effect at patients with chronic generalised periodontosis of various severity level, chronic granulating periodontitis, chronic periodontitis, including an exacerbation stage.
FIELD: medicine; pharmacology.
SUBSTANCE: edible membrane including effective quantity of film-forming substance, representing an admixture of maltodextrin, an excipient, a hydrocolloid and effective quantity of an extract of a magnolia bark, with a certain minimum quantity of an extract of bark from membrane weight. Method of disinfection of an oral cavity by placing of edible membrane in an oral cavity, thus the membrane contains effective quantity of the film-forming substance representing an admixture of maltodextrin, an excipient, a hydrocolloid and effective quantity of an extract of a magnolia bark with a certain minimum quantity of an extract of a magnolia bark from membrane weight. The method of obtaining of the edible membrane, including preparation of the aqueous solution containing maltodextrin, a hydrocolloid and an excipient, addition in the specified aqueous solution of effective quantity of an antimicrobic agent, and the specified antimicrobic agent contains an extract a magnolia bark; and also drying of the specified aqueous solution for formation of dry edible membrane. The method of treatment for reduction of quantity or depression of activity of bacteria in an oral cavity, including maintenance of edible membrane and introduction to the person requiring treatment of the specified membrane, and as a result of such treatment, occurs reduction of quantity or deactivation of bacteria in an oral cavity of the specified person. The edible membrane containing effective quantity of film-forming substance, including an admixture of maltodextrin, an excipient and a hydrocolloid, and effective quantity of an extract of a magnolia bark for depression of concentration Porphyromonas gingivalis (P. gingivalis) and Fusobacterium nucleatum (F. nucleatum) in consumer's oral cavity, and structure provides certain concentration of an extract of a magnolia bark in a consumer's oral cavity.
EFFECT: increased efficiency for disinfection of an oral cavity and refreshing of breath.
71 cl, 4 tbl
FIELD: medicine; stomatology.
SUBSTANCE: compound contains in wt. %: butylated hydroxytoluene 0.02-0.03, camphorquinone 0.05-0.15, trimetacrylatetriethanolamine 0.26-0.27, methyl silicone 5.4-5.6, polymethyl metacrylate 5.4-5.9, kabosile 36.0-37.0, sodium fluoric 4.9-5.1 and oligourethanemetacrylate OUA 2000F - the rest.
EFFECT: compound is not rigid; plastic; it is intended for teeth with drawn walls; reduces the price of sealing cost.
2 ex, 2 tbl
FIELD: medicine; dentistry.
SUBSTANCE: invention implies production of therapeutic agent and treatment method for periodontium and pulp diseases as well as to production of periodontal tissue regenerative transplant neurotrophic agents as active substance.
EFFECT: invention provides more effective endodontic therapy.
23 cl, 8 ex, 43 dwg
FIELD: medicine, stomatology.
SUBSTANCE: medicinal and preventive elixir for oral cavity care contains alcohol, surface-active substance, glycerin, perfume, biologically active additive with chloroform extract of herbs, i.e. nettle, plantain, myrrh, flowers of chamomile and calendula, Vitamin 'A', sodium fluoride, anion-active SAS, antiseptic, as preservative - nipagin, nipasol, perfume, colouring agent.
EFFECT: prolonged biological activity, anti-inflammatory capacity and expressed desensitising property.
2 cl, 4 ex
SUBSTANCE: invention refers to medicine, particularly to experimental cardiopharmacology and can be used for correction of endothelial dysfunction in experiment ensured by modelling endothelial dysfunction in laboratory animals during 7 days through daily intraperitoneal introduction of L-nitro-arginine-methyl ester dosed 25 mg/kg and followed with endogastric introduction of macrolide Midecamycin in single dose 10 and 30 mg/kg a day.
EFFECT: method ensures effective correction of endothelial dysfunction due to anti-oxidant action of Midecamycin.
1 ex, 1 tbl
SUBSTANCE: invention refers to experimental medicine, particularly to experimental cardiopharmacology and can be used for endothelium dysfunction correction. For this purpose dysfunction is modelled by intraperitoneal introduction of L-nitro-arginine-methyl ester dosed 25 mg/kg daily during 7 days to rats. This therapy is combined with endogastric introduction of macrolide agent Josamycin dosed 10 and 30 mg/kg singly a day.
EFFECT: method provides correction in any antioxidant profile.
1 ex, 1 tbl
SUBSTANCE: invention concerns medicine, in particular, gastroenterology, and concerns treatments of a peptic ulcer of a stomach and a duodenum, associated with Helicobacter pylori. For this purpose introduction of antihelicobacter antibiotics and a Linex medication is performed. Upon termination of the course of treatment with antihelicobacter antibiotics it is continued to administer Linex medication on 2 capsules 3 times a day within 3 days.
EFFECT: method allows warning development of implications of the dysbacteriosis caused by reception of antihelicobacter antibiotics, and also provides cupping of dyspeptic implications within 3 days after cancellation of antibiotics at any duration of the course.
SUBSTANCE: invention relates to medicine, in particular to gastroenterology, and applies to treatment of chronic duodenal obstruction. For this purpose erithromicin is introduced on account of 3.0 mg/kg of body weight 3 times a day. Additionally Alfadol-Ca is introduced in case of initial normocalcemia in dose 1 capsule 1 time a day. In case of initial hypocalcemia Alfadol-Ca dose is 1 capsule 2 times a day. Course of treatment is 3 months.
EFFECT: method ensures elimination of symptoms of chronic duodenal obstruction in patients with functional form of chronic duodenal obstruction in combination with syndrome of disturbed absorption and normalisation of calcium balance in organism.
2 dwg, 1 tbl, 2 ex
SUBSTANCE: it is offered: Ivermectine application for obtaining of a pharmaceutical composition for local application for treatment of pink eels, a pharmaceutical composition for the local drawing, intended for the person, containing Ivermectine both certain dissolvents and water, and also its application in dermatology.
EFFECT: invention is distinguished by Ivermectine high stability in compositions at different value pH and good acceptability for a skin.
24 cl, 10 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention concerns pharmaceutical industry, particularly means of cerebral cardiovascular disease treatment and prevention. Pharmaceutical composition for cerebral cardiovascular disease treatment and prevention includes definite steroid saponins in definie amount. Method of pharmaceutical composition preparation involves weighing furostanol saponin and spyrostanol saponin, mixing them at definite ratio, adding pharmaceutically acceptable adjuvants. Method of obtaining pharmaceutical composition involves cutting or breaking of rhizome of definite plants, extraction, extract filtering and passing through a column with absorbing resin, eluate disposal, column flushing with water, flush water disposal, column elution, eluate collection and concentration, adding alcohol to concentrated solution, filtrate collection after filtration, filtrate concentration and drying, adding pharmaceutically acceptable adjuvates. Pharmaceutical composition is applied in pharmaceutical medicine production for cerebral cardiovascular disease treatment and prevention.
EFFECT: highly stable composition efficient for cerebral cardiovascular disease treatment and prevention.
17 cl, 4 dwg, 8 tbl, 8 ex
SUBSTANCE: invention concerns crystalline azithromycin L-malate monohydrate of formula (I) with high stability, solubility and non-hygroscopicity. Also invention concerns pharmaceutical composition for microbe infection treatment, based on compound of the formula (I), and method of obtaining compound of the formula (I), involving: a) interaction of azithromycin with malic acid in aqueous organic solvent, or b) recrystallisation of water-free azithromycin L-malate from aqueous organic solvent.
EFFECT: obtaining crystalline azithromycin L-malate monohydrate of formula (I) with high stability, solubility and non-hygroscopicity.
15 cl, 7 tbl, 7 dwg, 18 ex
FIELD: medicine; venereology.
SUBSTANCE: treatment of urogenital Chlamidia infection in women is ensured by subcutaneous introduction of betaendolysin dosed 7-8 ng/kg/day within 5 days, 5-6 days before menstruation, combined with antibacterial therapy prescribed 3-4 days before menstruation.
EFFECT: klendusity activation before physiological immunodeficiency and optimum for causative agent elimination.
FIELD: medicine; gastroenterology.
SUBSTANCE: method includes introduction of omeprazol and mixture of the following antibacterial medications - clarithromycin and amoxicillin in almagel suspension. Additionally 30 minutes before introduction of suspension, 20 mg of buscopan are introduced orally. At that doses of antibacterial medications used are 6 times less than the recommended ones.
EFFECT: reduction of antibacterial medications dose due to slowdown of stomach peristaltic activity and clearance of stomach mucous membrane.
FIELD: chemistry; pharmacology.
SUBSTANCE: present invention relates to new non-steroidal anti-inflammatory compounds represented with the formula I: , where M is a macrolide subunit of the formula , D is a non-steroidal subunit, obtained from a non-steroidal anti-inflammatory drug, L is a connecting group with the formula X1-(CH2)m-Q-(CH2)n-X2, or their pharmaceutically permissible salts or separate diastereoisomer. Apart from that, this invention relates to the method of obtaining compounds of the formula I (versions), to the pharmaceutical composition on the basis of the compounds of formula I or their pharmaceutically permissible salts and also to the administration of formula I or their pharmaceutically permissible salts to obtain medicine (versions). The values of the substitutes R1-R6, A, B, E, U, Y, Z, W, S1, M, D, X1, X2, Q, m, are shown in the formula of the device.
EFFECT: obtaining new non-steroidal anti-inflammatory compounds.
11 cl, 1 tbl, 7 dwg, 23 ex
SUBSTANCE: invention concerns medicine, namely to psychiatry, and can be used at treatment of patients with a neurosis of obsessional conditions. For this purpose within 20 days pharmacotherapy is performed, including Diazepamum introduction, Mexidol and Tymogene. Thus Tymogene is administered intramusculary in a dose of 0.1-0.125 mg once in two days in amount of 10 injections. Simultaneously with pharmacotherapy within the first 15 days hyperbaric oxygenation is performed.
EFFECT: method provides appreciable reduction of the undesirable effects arising owing to administration of benzodiazepine anxiolytics, namely muscle relaxing activity, and also prevents possibility of medicinal dependence to the given group of preparations.