Method of and device for filling powder into socket

FIELD: mechanical engineering; powder filling devices.

SUBSTANCE: proposed invention relates to method and device for filling powder into socket with use of meter provided with elongated space with open end and plunger opposite to open end and capable of moving along space to form variable-volume space between plunger and open end. Method provides, with plunger forming the volume exceeding volume of socket, driving of open end into powder source to fill powder into volume, placing of open end over socket, movement of plunger to force powder from open end into socket and compression of powder to preset packed density. Feeding of powder into socket is provided by plunger moved with force which does not depend on displacement of plunger, and moving of open end from socket to leave socket filled with powder at preset packed density.

EFFECT: provision of control of force on plunger in process of socket filling and preset volume density of powder.

33 cl, 11 dwg

The present invention relates to a method and apparatus for introducing powder into the slot, allowing you to move the powder, for example for inhalation, from the source and unload in the nest substrate.

Well known for the preparation of a dry powder for inhalation using a platform for powder and moving powder from this platform in the slot of the carrier (substrate)using a dispenser. In particular, you can specify U.S. patents 3,847,191, 4,542,835 and 5,826,633.

Platform for powder usually made in the form of a rotating disk with a squeegee, which serves for smoothing the surface of the powder. This provides the powder with a constant bulk (volume) density and smooth surface.

The dispenser is made in the form of a tube with sharp edges and with the Central plunger. The plunger is positioned so that to form inside the tube period equivalent to the desired dose of the powder. Then the spout is introduced into the powder on the platform for the powder to fill the formed volume. In this way, when the dispenser away, it is transferred portion of the powder in the desired quantity. The powder may be moved to the substrate, and then introduced into the slot by the action of the plunger.

This known system has several disadvantages. In particular, after the discharge of the dispenser from the platform to the powder, the powder is poured from the tip of the dispenser directly on trainim way. In addition, the powder may be lost during the move from the platform to the substrate, and the powder can stick to the inner and outer surfaces of the dispenser instead to move in the slot. In this way there are discrepancies in the amount of powder introduced into the slot.

The present invention is to overcome or at least reduce the problems of known systems.

According to the present invention, it is proposed a method of introducing powder into the socket having an open side providing:

the orientation of the slot with the open side facing at least partially upwards;

providing nest powder with a volume greater than the volume of the nest;

the compression volume of the powder to a predetermined bulk density; and

remove excess powder to leave a nest full of powder with a given bulk density.

Thus, the substrate is filled with a reliable and repeatable manner essentially the same amount of powder. In particular, this quantity is determined only by the amount of nests and compression applied to the powder. Apply compression can be controlled in various ways. It is clear that in practice a given bulk density will cover a small range of bulk densities due to different tolerances and requirements for powder, placed supply plug. Therefore, the operation of the compression of the powder allows small changes to the actual bulk density. These changes can be seen as a given bulk density, and they all lead essentially to the same amount of powder, which is required when using it.

The amount of powder may be limited by space, adjacent the open side.

According to the present invention, it is proposed a method of introducing powder into the nest using a dispenser having an elongated cavity with an open end and a plunger opposite the open end and capable of moving along the cavity for the formation, between the plunger and the open end, a space of variable volume, including:

education using a plunger volume greater than the volume of the nest, the introduction of the open end in the source powder to fill this volume powder,

the location of the open end over the nest,

movement of the plunger to eject the powder from the open end into the slot and compress it to the desired bulk density, and

the abstraction of the open end from the socket to leave the nest full of powder with a given bulk density.

Thus, the slots are filled specified amount of powder does not depend on, to a specified number of correctly transferred from the source powder to GN is SDU. If the amount of powder captured by the dispenser, is changed, i.e. if the powder falls out of the dispenser when migrating, or different amounts of detergent left in the dispenser after filling the slot, it will not have a direct effect on the amount of powder provided in the socket. In particular, the socket is completely filled and compacted to a predetermined bulk density. Thus, the amount of powder in the nest directly affect only the volume of the nest and the compression applied to it. Controlling compression can be done in various ways. An additional advantage compared with the known systems is that the socket is completely filled and, therefore, they have no free space above the product or extra volume. In other words, no nests unoccupied volume. The exception of space above the product can significantly reduce the content of undesirable moisture and gases in a sealed nest. In addition, the weight of the powder filling the nest, less dependent on the state of the powder in the source. In particular, it is not important even to the powder in this source had known density, because at the stage of compression, it would in any case be reduced to a predetermined bulk density.

In one embodiment, the dispenser has many of these elongated cavities with the respective open ends and an appropriate amount of the above-mentioned plungers, opposite the respective open ends and capable of moving along the cavities for education between the plungers and the open ends of the respective spaces of variable volume, the method additionally provides for the movement of these plungers together, for example, at the same time.

According to the present invention, a device for introducing powder into the slot containing the metering device, which has:

an elongated cavity with an open end;

the plunger opposite the open end and capable of moving along the cavity for the formation, between the plunger and the open end, a space of variable volume for receiving powder; and

actuator to move the plunger along the cavity, and an actuator able to move the plunger to the open end so as to compress the powder to a predetermined bulk density.

Thus, the powder can be introduced into the socket and compress to a predetermined bulk density. It has become possible to completely fill the slot and get the aforementioned advantages.

In addition, you can perform fine adjustment of the process, changing the compression provided by the plunger. This allows variations in the properties of the powder and sizes of slots to be filled.

In one embodiment, the dispenser has many mentioned elongated cavities according to the respective open ends; and

the appropriate amount of the above-mentioned plungers opposite referred to the respective open ends and capable of moving along the cavities for the formation, between the plungers and the open ends of the corresponding spaces of variable volume; and in which

the actuator moves all the corresponding plungers together.

The dispenser preferably is returned to the source of powder, and the plunger is moved to the open end, or at least partially through it, to push out any remaining detergent from the dispenser and to return the remaining powder in the source.

Thus, the dispenser can make a loop to fill successive nests. Thanks to the return of the remaining powder in the source, this powder can be used again to fill the other slots. In addition, return it to the source allows the source to handle the powder and return it in its uncompressed state.

The system fills the nest with excellent accuracy. However, the surface of the powder into the nest, you can straighten, to remove any small amounts of excess powder. This can be achieved by holding the squeegee over the surface of the substrate in which is formed the slot, and therefore, cleaning the surface, removing any excess powder.

Thus, the system is less dependent on the precision is, with which the remaining powder into the open end is separated from the powder into the nest. Processing squeegee ensures that all slots will be filled in the same way, and clear the surrounding surface of the powder, thereby facilitating the subsequent adhesion of the sealing layer.

The actuator may cause compression of the powder through the movement of the plunger or plungers to the open end with a preset force.

Alternatively, the plunger can be moved at a controlled distance from the gap between the tube of the dispenser and the surface surrounding the slot determining the pressure in the hole. In particular, the excess powder will sleep on the side of the gap, determining the pressure at the input Jack, so it does not matter if the resistance to movement of the plunger is variable.

The actuator can move the plunger or plungers to the open end with a force that does not depend on the displacement of the plunger or group of plungers.

The actuator may be a pneumatic cylinder, which moves the plunger or plungers to a set pressure.

This provides a convenient mechanism that can compress the powder to a predetermined bulk density.

The dispenser is preferably in the form of a tube, and the profile of the edge of the tube formed around its open end, is chosen so as to optimize the synchronize two processes - capture of the powder and its issuance in the container (nest). Sharpened edge of the tube is preferred to allow the introduction of the dispenser to the source of powder to fill the space in the tube powder. However, the flat edge of the tube can be advantageous for sealing relative to the surfaces surrounding the respective sockets without damaging these surfaces to ensure that the powder from the space in the tube received inside the socket and tightened as required. The profile of the region will therefore depend on the specific design of the container and the properties of the powder.

The sharp profile is preferred to allow the introduction of the dispenser to the source of powder to fill the space with powder. In addition, the sharp edge can be advantageous when combined with the surfaces around the appropriate slots to ensure that the powder from the space to be entered into the slot and tightened as required.

Preferably, the device further comprises a transmitting mechanism for moving the spout between the source powder and the socket control system to control the transmission mechanism and the drive.

Thus, the system can be automated to provide the ability to populate successive nests powder from the source. As will be discussed below, the use of multiple dosing, serial slot or group of slots can be filled accordingly.

The control system preferably controls the transmission mechanism and the actuator so that automatically, in turn, enters the open end into a source of powder, put the open end over the nest, moves the plunger to eject the powder from the open end into the slot and compress it to the desired bulk density, to take the open end from the nest to return the dispenser to the source of powder and to move the plunger to dislodge any remaining powder.

Therefore, the management system provides a cycle which can be repeated for successive nests.

The control system preferably controls the drive, before the introduction of the open end into a source of powder, so as to position the plunger to form a volume greater than the volume of the nest. The control system is not required to control the position of the return of the plunger, simply to begin the return or release the plunger to return. The plunger can be returned to its original position by any suitable mechanism. His final position can be determined simply by the length of the path (stroke) of the plunger in the cavity, or some adjustment by means of screw type, to determine the position of the stop.

Volume greater than the volume of the nest, predpochtitel is but is sufficient to obtain, when the powder in the above-mentioned space is compressed to a predetermined bulk density, volume of compressed powder is greater than the volume of the nest.

This is required when the powder is reduced in volume under compression.

When placed over the socket, open end, essentially the entire open area of the slot is preferably located inside the open end.

This ensures proper filling of the nest powder.

It is clear that it may be important to center the dispenser on the nest, however, the diameter of the tube of the dispenser must not be larger than the diameter of the socket. For some parameters, the filling process can be performed equally well with the diameter of the tube dispenser is less than the diameter of the socket.

The device is preferably provided with many dispensers are located in the group corresponding to at least part of the group of slots in the substrate.

Thus, many nests can be filled simultaneously. In particular, some or all of the nest substrate can be completed in one cycle of the device.

The method and apparatus is particularly advantageous when used for the introduction of a dry powder for inhalation in the nest substrate type blister packaging.

In particular, it is proposed to use a substrate holding the liners, each liner forms a socket. The liners can be removed from the substrate to about the excite the grant contained in the powder. In the preferred construction, the substrate is formed as a plate with through holes, each through hole contains the corresponding liner. Liners and, therefore, the socket may be formed using a molding process in the substrate or, in a variant, be molded separately and then paste into the substrate.

The invention is further explained with the embodiments thereof with reference to the accompanying drawings, on which:

Fig. 1(a) and 1(b) are schematic views of the device according to the invention;

Fig. 2(a) to 2(g) stage of the preferred method according to the invention; and

Fig. 3(a) and 3(b) shows the combination of a tube dispenser with the socket.

As shown in Fig. 1(a), to move the powder from the source powder 20 into the slot 32 of the substrate 30 provided with the dispenser 10. The actuator or drive mechanism 40 is provided for control or actuation of the dispenser 10, and the transmitting mechanism 50 is provided to move the dispenser 10 from a source 20 of the powder to the socket 32. The device is controlled from the control system 60, which, in particular, can drive transmission mechanism 50 and a drive mechanism 40.

It is clear that Fig. 1(a) is very sketchy and is provided only to illustrate the various components of the device. The drive mechanism 40 and the transmitting mechanism 50 can have an alternative implementation. In particular, the transmitting mechanism may be in the form of a linear mechanism, instead of the rotary mechanism shown in Fig. 1(a). Indeed, it is possible to provide the movement, moving the source 20 and the substrate 30, and not the dispenser 10, that is, by moving the source and the substrate, and leaving the fixed dispenser.

The device may also contain a variety of dispensers are located in the group corresponding to at least part of the group of nests of the substrate or, as shown in Fig. 1(b), the dispenser may include multiple tubes arranged in a group corresponding to at least part of the group of nests of the substrate.

Now how the whole system with reference to Fig. 2(a) to 2(g).

As shown, the dispenser 10 includes a plunger or pistil 12. The dispenser 10 is preferably in the form of a tube, which has an axial passage forming an elongated cavity. The cavity extends from the open end 14 and the plunger 12 are able to move to the open end 14 and from him along the cavity. Thus between the open end 14 and the plunger 12 is formed a space 16 variable volume. The actuator 40 moves the plunger 12 along the cavity of the dispenser 10 to change the amount of space 16, as required.

Cross-section of the cavity and the plunger is preferably round, although you can use any cross-sectional shape. The shape and cross-sectional area of the plunger 12 and the cavity correspond to each other is GU, in order to ensure the normal position of the piston/cylinder.

As will be described below, the cavity is used to receive the powder. The gap between the plunger 12 and the walls of the cavity is chosen accordingly. In the device used powder for inhalation, which is very thin, there is a risk that some of the powder will pass between the plunger 12 and the cavity walls. Therefore, the clearance between the plunger 12 and the cavity walls do not make too tight, as the powder will be captured in the trap, and that will adversely affect the effort required to move the plunger 12. On the other hand, if the clearance is too loose between the plunger 12 and the cavity walls will move a significant amount of powder so that it will affect the precision.

As shown in Fig. 2(b), the dispenser 10 is introduced into the powder 22 source 20. This source shows just how small the container. However, it is preferable to provide a platform for powder known type, for example, with a rotating disk with squeegee for smoothing the surface of the powder.

When the dispenser 10 is introduced into the powder 22, the plunger 12 is in position, withdrawn from the open end 14 to provide a space 16, having a volume greater than the volume of the socket, which should be placed the powder.

As shown, the dispenser 10 is made in the form of a tube with astronamy edges. Sharpened edge 18 around the periphery of the open end 14 is advantageous to allow the dispenser to easily and accurately enter the powder 22. Indeed, this is further enhanced by providing the dispenser 10 by a thin wall along its length at least to the depth to which it should be entered in the powder 22.

As shown in Fig. 2(c), the dispenser 10 is then removed from the powder 22, while grabbing a portion of the powder 24 in the space 16 between the open end 14 and the plunger 12. Then, the dispenser 10 is moved toward the socket 32 of the substrate 30. This can be achieved by the transmitting mechanism 50, such as shown in Fig. 1(a) and 1(b), or moving source 20 of the powder and the substrate 30. The open end 14 of the dispenser 10 is then placed over the socket 32 of the substrate 30. In particular, being held against his hole socket 32 and, in this preferred embodiment, the peripheral edge 18 of the open end 14 is in contact with the periphery of the hole of the socket 32, to provide a combination or essentially seal.

Fig. 3(a) and 3(b) are presented to illustrate the factors related to the alignment tube of the dispenser with the socket.

As shown in these drawings, the tube dispenser 10 is displaced from the slot 32 at the distance L. it is Established that a significant shift may lead to a change in bulk density in the nest. The alignment of the slot with the dispenser should be better than 20% of the width is NESDA, and more preferably better than 10%.

The reason for this error is that if the powder 44 is caught between the plunger 12 and the surface surrounding the slot 32, it can create sufficient resistance to movement to stop the plunger. In addition, a larger gap G, on the other hand, allows the powder to leak when put pressure plunger.

In many cases, the dispenser pipe will be in contact with the surface 45, surrounding the slot 32, so that the height H of the tube of the dispenser above the nest will be zero. However, in some cases, this height may be selected to some value greater than zero. In particular, it is possible to choose to avoid damage to the tube dispenser or nests, or allow a small amount of powder to leak, to prevent excessive compaction.

Additionally, as shown in Fig. 1(b), in the case when simultaneously using multiple tubes pipettors, any angular offset between the plane of the ends of the tubes 10b of the dispensers and the plane of the tops of the sockets will inevitably cause at least a slight change in height.

If the clearance is sufficient to allow the powder to leak out the side during the move, the compression ratio may be lost.

The required sizes will depend on the particle size of the powder, the characteristics of the flow and can be determined by the specialist according to the specific option.

Tube feeders can choose the width, the width of the slot which is less than, equal to or greater than it.

You can make a choice, given the precision mechanics of the device and the flow characteristics of the powder.

The use of the dispenser, which is less than the slot permits a displacement of the dispenser relative to the socket, without compromising performance, since the dispenser will still be over the nest. Smaller dosage may be required for large nests as wide dispensers will not capture the powder. However, the force of compression (compression ratio) of the dispenser will not be applied over the entire surface and, for a freely running powders, this can lead to unreliable management density.

The use of a metering device of the same size with the socket enables better control of the uniformity of the density compression ratio, but requires precise alignment.

The use of the dispenser, which is more nests, reduces alignment requirements and reduces the height of the powder in the dispenser pipe compared to conventional tubes. However, in the case logosauce powders, the powder may get stuck around the edges, preventing the application of the desired pressure to the powder in the socket.

Therefore, the ratio between the width of the slot and the width of the dispenser should be chosen depending on the accuracy that can be achieved in position the implement and the characteristics of the powder. Typically, the preferred ratio will be within ±20% of the units.

In the context of filling substrates dose of powder for inhalation, it is proposed that the edge 18 of the open end 14 in contact with the surface of the substrate 30 is slightly outside the periphery of the hole of the socket 32, for example, approximately 0.5 mm, However, the edge 18 should not be much longer, since then the powder will not leak and will be a seal of the captured powder.

As described above, in this embodiment, the connection between the edge 18 and the surface of the substrate 30 should be sufficiently tight to prevent leakage of too much powder, but enough freedom to let out the air.

This design is shown in Fig. 2(d).

The plunger 12 can then lead to the open end 14. He pushes the powder from the dispenser into the slot 32. The actuator 40 moves the plunger 12 in this respect, so that the powder 24 is compressed to a predetermined bulk density. In this preferred embodiment, the plunger is moved with a preset force. In particular, the force applied to the plunger (and from it), preferably not depends on its displacement. In this regard, the actuator 40 is preferably in the form of a pneumatic mechanism, so as to fill the slot of the plunger at least you were the AMB using the specified air/gas pressure, to ensure that the powder 24 is compressed corresponding to a given bulk density. For the variant according to Fig. 1(b), the plungers can be mechanically jointed and can be controlled from a single pneumatic cylinder, or each plunger can move the corresponding pneumatic cylinder connected to a common source of air/gas.

Here it should be noted that, as mentioned above, the amount of space 16 at the stage of introduction of the powder shown in Fig. 2(b), exceeds the volume of the socket 32. Thus, as shown in Fig. 2(e), when the socket 32 is filled with powder 24 of the dispenser 10, the plunger has not yet reached the open end 14 and, therefore, the powder 24 is still in the space 16 between the open end 14 and the plunger 12.

It should be understood that the amount of powder 24 may decrease when it is compressed by the plunger 12. In this case, the initial volume of the space 16 that is used when the dispenser 10 is introduced into the powder 22, as shown in Fig. 2(b), must be sufficient so that, when the powder is compressed to a predetermined bulk density, the final volume of compressed powder was still more volume nests. In other words, the powder was still in the dispenser 10 when the socket 32 will be filled.

At the next stage, as shown in Fig. 2(f), the dispenser 10 and, therefore, the open end 14 away from the substrate 30. As shown, this leaves p is rosok 26, remaining in the space between the open end 14 and the plunger 12.

For the successful implementation of the method it is important that when the dispenser away from the nest, the powder in the dispenser remained in place and cleanly separated from the powder in the nest on the surface of the nest, leaving the nest, filled only over the surface of the nest.

This allows using a simple squeegee to remove the excess, leaving a nest full and without additional powder, poured over the nest. For many powders have found that it is reliably provided by a simple lifting of the tube dispenser perpendicularly from the plane of the orifice slot. However, for some powders, split point may be insufficiently reliable. In these cases there may be additional steps of separation. They may include:

a) lateral movement of the dispenser by a distance equal to the width of the slot, so that the powder moves to the top of the nest;

b) a transverse wave with an amplitude less than the width of the slot for the sliding part of the column of powder in the desired place;

c) the tilt tube of the dispenser to initiate separation of the connection between the spout and socket.

When lateral movement of the dispenser can put the open end of the dispenser on a flat surface, and adjacent to this surface, the plunger in the dispenser can be activated again to additionally the compact powder, ensuring that he will remain in the dispenser when it is raised. Therefore, the dispenser pipe is used as a squeegee to ensure a clean, flat surface of the powder in the socket.

As shown in Fig. 2(g), then the dispenser 10 can be returned to the source 20 of the powder. By the time the plunger 12 is moved so that its front face surface located at the open end 14 or, preferably, outside, and the remaining powder 26 is returned to the source 20 of the powder.

It is clear that, as schematically shown in Fig. 2(f), excess powder 28 can be left in the socket 32. In General, it may be relatively small quantity. However, as mentioned above and shown in Fig. 2(g), powder 28 in the socket 32 can be trim in order to remove any excess powder. In particular, a squeegee or scraper 70 can be removed from the surface of the substrate 30 in order to clean off any excess powder. Scraper 70 can move on command of the control system 60.

Finally, although not shown, the plunger is moved back into the position of Fig. 2(a). Although it may be initiated by the control system 60, it is possible to provide a separate mechanical and return the position of the stop.

Thus, in conclusion, with the slots 32 of a given size may reliable and repeatable movement of specified quantities of powder in these nests is. In particular, this amount of powder is determined by the volume of the nest and a given bulk density created by the plunger 12.

It is clear that this system can be used to move powders of any kind. However, frequent application is filling in the substrate powder for inhalation. For these powders, it is extremely important that the substrate reliably and repeatable way were secured by specified amounts or doses.

The substrate can have any desired shape and size, for example, typically known substrate in the form of blister packs. However, the surface of the substrate surrounding the periphery of the slots 32, preferably should be almost flat, to allow proper connection edge 18 of the open end 14, and also to improve pozdravlenie with a scraper 70. Of course, other shapes and configurations for the additional edges 18 and the surfaces of the substrate 30 together with scrapers 70 corresponding form.

Although the invention is described with reference to the dispenser, it can also be translate in other ways. For example, with the slots facing upward, the volume of the powder can be provided for nests in any convenient way and to compress to a predetermined bulk density. For each nest, the appropriate amount of powder may be limited by space, adjacent the open side of the socket, before he bodø is compressed in the socket.

As described above, to control the amount of powder in the nest, it is necessary to accurately control the density to the target value. For many powders, this can be achieved by using the force or pressure applied by the plunger when the powder is moved from the dispenser into the slot.

However, for some powders and form nests can be difficult to ensure that the force applied to the plunger, in a reproducible manner over the powder in the dispenser pipe to compress the powder in the slot to the desired bulk density.

This applies in particular to easily compressible sticky powders, when even a small length of the powder in the tube will be stuck and will not slide forward while pulling.

In these cases it may be appropriate to move the plunger with the help of some additional mechanism which ensures the movement of the powder into the nest. Move the powder in the slot of the dispenser in these cases can be achieved by using:

- obstuctive or vibration of the tube of the dispenser, allowing the powder to fall under the force of gravity;

- vibration of the dispenser while pulling powder to help move the powder in the nest;

- creating a differential pressure on the powder to help it move into the slot.

In Fig. 1(a) shows the mechanism 110 to create vibrations in trusteduser.

In these cases, after the powder has been moved from the tube in the socket, you can use a separate process to set the bulk density of the powder in the socket on the specified value. This can be achieved by using:

compression flat surface by pressing with a known force on the surface of the powder. For this you can use the plunger movement;

- obstuctive or vibration of the socket to allow the powder to settle under the force of gravity;

- suction through the slot to draw the powder into place;

rapid rotation of the socket around the point over the nest, using centrifugal force to durable press the powder into the nest.

In cases where the present invention is used for filling containers with the medication, the powder may consist of two components, drug and filler. However, the concentration of drug in the batches may vary. If this is the case, then, to ensure that each slot contains the same amount of medicinal product from batch to batch, it would be preferable to maintain the same amount of slots, and to be able to adjust the volume density during filling.

To ensure this, it is proposed to change the volume density in the nest during the filling or after it./p>

With conventional medicinal powders, where the filler is lactose, bulk density can be controlled within a sufficient range to accommodate an ordinary party to a change of concentration of a batch of a medicinal product, which is rarely more than ±5%. For these powders management volume density can be ensured by controlling the force on the plunger during the filling of the slot. Pressure between 1 bar and 10 bars, applied by the plunger to the powder, are suitable for good compaction of the powder into the nest.

The change in bulk density by the force of the plunger depends on the powder and the geometry of the slot. For plunger with an area of 28 mm²and aspect ratio of approximately 3:1, the volume density of lactose powder can be increased by 10%, increasing the pressure of the plunger from 2 bar to 4 bar.

As mentioned above, in cases where the method is used for simultaneous filling of multiple nests, requires lots of tubes, pipettes, or many separate dispensers, or, as shown in Fig. 1(b), or as a dispenser with multiple dosing tubes.

Thus it is necessary to consider several detailed embodiments.

If the distance between the tubes of the dispenser similar to the width of the tube of the dispenser, then the powder will seek to fill the gap between the tubes. This is not lateline. To overcome this, you can increase this space or remove the powder, when the number of dispensers is still above the layer of powder.

In cases where the method is carried out with a number of dispensers having a respective tube, each dispenser may have an independent tool for creating the effort on your plunger. However, it can be extremely challenging for a cost effective implementation.

To allow the use of a separate dispenser, in some cases it may be preferable to provide an approximation of independent control of force by, for example:

- hard install all of the plungers together and bring into action all of them in parallel from a common pressure source;

- installation of each plunger springs from a common plate and movement of this plate at a fixed distance to compress the springs so that each has created pressure for its own plunger;

connection group plungers with a common pressure source;

- minimizing the change of quantity of powder in the range of dispensers to provide the same offset all of the plungers in this series to create the same effort on each plunger.

Although, as a private advantage of the present invention, the final control volume density in the nest is carried out after filling, m which may be obtained advantages, provide management bulk density of the powder, take the tube of the dispenser. This can be used for:

- minimizing powder falling from the dispenser during filling;

- to minimize the density changes between the tubes of the dispenser in the series;

control the final density of the fill.

Bulk density in the tube (tubes) of the dispenser may be different due to a number of parameters, showing how the dispenser penetrates through the powder in the powder layer. These options include:

the height of the end of the dosing stopped above the base layer of powder;

the depth of the layer of powder;

distance from the plunger to the open end of the tube dispenser.

The value of each option can be determined experimentally, and they will be customized for a specific cooking techniques powder and the geometry of the slot.

1. The method of introducing powder into the socket having an open side providing: the orientation of the slot with the open side facing at least partially up the software in the nest volume of powder more volume nests, the compression volume of the powder to a predetermined bulk density and the removal of excess powder to leave a nest full of powder with a given bulk density, and the introduction of the powder into the nest carry out what longeron (plungers), roaming (roaming) with a force that is not dependent on the displacement of the plunger (plungers).

2. The method according to claim 1, in which the volume of the powder is limited to the space adjacent to the open side.

3. The method of introduction of the powder into the nest using a dispenser having an elongated cavity with an open end and a plunger opposite the open end, is able to move along the cavity for education between the plunger and the open end of the space variable volume, providing: education using a plunger volume greater than the volume of the nest, the introduction of the open end in the source powder to fill this amount of powder, the location of the open end over the nest, moving the plunger to eject the powder from the open end into the slot and compress it to the desired bulk density, and movement of the plunger carried out with a force that is not dependent on the displacement of the plunger, and the abstraction of the open end from the socket to leave a nest full of powder with a given bulk density.

4. The method according to claim 3, in which the plunger is moved with a preset force.

5. The method according to claim 3, in which the dispenser has many mentioned elongated cavities with respective open ends and an appropriate amount of the above-mentioned plungers, respective opposite open ends and capable of displacement is the change along the cavities for education between the plungers and the open ends of the respective spaces of variable volume, the method further provides for the movement of these plungers together.

6. The method according to claim 5, providing for the movement of the plungers by applying a given force to the plungers, as a group.

7. The method according to claim 3, further providing for: the return of the dispenser to the source of powder and the movement of the plunger (plungers) to the open end or, at least, partially through it to push out any remaining detergent from the dispenser and to return the remaining powder in the source.

8. The method according to claim 3, further providing for leveling the surface of the powder in the slot to remove any excess powder.

9. The method according to claim 8, in which the alignment includes on the surface of the powder squeegee to remove any excess powder.

10. The method according to claim 3, additionally providing for the vibration of the dispenser to facilitate the movement of the powder from the said space or spaces.

11. The method according to claim 3, in which the open end is removed from the slot lateral movement with respect to the slot transversely of the specified surface to control the separation of the powder into the nest from the powder in the dispenser to act as a squeegee.

12. The method according to any of PP-11, in which the volume exceeds the volume of the socket, sufficient to, when the powder in the above-mentioned prostranstva to a predetermined bulk density, the obtained volume is compressed powder was greater than the volume of the nest.

13. The method according to any of PP-11, in which the open end is placed over the nest, essentially the entire outer peripheral edge of the socket is inside the open end.

14. The method according to any of PP-11, which use a variety of dispensers are placed in the group corresponding to at least part of the group of slots in the substrate.

15. The method according to any of PP-11 for use with the introduction of a dry powder for inhalation in the nest substrates for distribution to consumers.

16. Device for introducing powder into the slot containing the dispenser having: an elongated cavity with an open end, the plunger opposite the open end and capable of moving along the cavity for education between the plunger and the open end space of variable volume, and the actuator to move the plunger along the cavity, and an actuator able to move the plunger to the open end so as to compress the powder to a predetermined density, the actuator moves the plunger to the open end with a force that is not dependent on the displacement of the plunger.

17. The device according to clause 16, in which the actuator is able to move the plunger to the open end with a preset force to compress the powder to a predetermined bulk density.

18. The device according to clause 16, in which the dispenser is made in the form of a tube with C is strannye edges or tube with flat edges.

19. The device according to clause 16, in which the dispenser has many mentioned elongated cavities with respective open ends and an appropriate amount of the above-mentioned plungers, opposite referred to the respective open ends and capable of moving along the cavities for education between the plungers and the open ends of the respective spaces of variable volume, and in which the actuator moves the whole multitude of the plungers together, and the actuator moves the plungers with a force that is not dependent on the displacement of the plungers.

20. The device according to claim 19, in which the actuator applies a specified force to the respective plungers, as a group.

21. The device according to claim 19, in which the dispenser contains many tubes with sharpened edges forming respective elongated cavity.

22. The device according to claim 20, in which the sharp edge is formed around the open end.

23. The device according to item 21, in which the sharp edge is formed around the open end.

24. Device according to any one of p-23, in which the actuator is a pneumatic mechanism and moving the plunger (plungers) to the open end (the ends) with a given force actuates the plunger to a set pressure.

25. Device according to any one of p-23, additionally containing a mechanism for the application of vibration to the dispenser to facilitate d is iginio powder from the said space or spaces.

26. Device according to any one of p-23, further comprising: transmitting mechanism for moving the spout between the source powder and the socket control system to control the transmission mechanism and the drive.

27. The device according to p, in which the control system controls the transmission mechanism and the drive to, in turn, automatically enter the open end into a source of powder, put the open end over the nest, to cause the plunger with a preset force to push the powder from the open end into the slot and compress it to the desired bulk density, to take the open end from the nest to return the dispenser to the source of powder and to cause the plunger to push out any remaining powder.

28. The device according to p in which the transfer mechanism removes the open end from the socket with a relative lateral movement of the socket and the dispenser to control the separation of the powder into the nest from the powder in the dispenser and to act as a squeegee.

29. The device according to p in combination with a socket, in which the control system controls the drive before the introduction of the open end in the source powder to position the plunger for the formation of a volume greater than the volume of the nest.

30. The method according to clause 29, in which the volume exceeds the volume of the socket, sufficient to, when the powder in the above paragraph is stranstvo compressed to a predetermined bulk density, the obtained volume is compressed powder was more of the volume of the nest.

31. The device according to item 30, in which the open end is placed over the nest, essentially the entire outer peripheral edge of the socket is inside the open end.

32. Device according to any one of p-23 with multiple dispensers placed in the group corresponding to at least part of the group of slots in the substrate.

33. Device according to any one of p-23 for use with the introduction of a dry powder for inhalation in the nest substrates for distribution to consumers.