Composition applicable as personal hygiene product and methods for using it

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to cosmetology and represents a composition applicable by a user as a personal hygiene product in the form of a bath or shower gel, containing: (a) no more than 11.5 wt % of an anionic surfactant representing alkyl sulphate, alkyl sarcosinate, or any combination thereof; (b) no more than 3 wt % of a zwitterionic surfactant representing fatty acid amidoalkylbetaine, (c) not less than 0.1 wt % of a hydroxyalkylcellulose derivative with a long-chain alkyl group; and (d) water.

EFFECT: invention provides preserving and improving the functionality, such as viscosity, smooth systemic action, foaming behaviour, low surfactant load, high biological degradability and low aquatoxicity of waste water flow.

22 cl, 3 tbl, 11 dwg

 

The level of technology

People all over the world are using (products) personal hygiene, such as soap and detergents, which generally leads to the fact that in the environment with wastewater every day gets a huge amount of these materials. Among the products used for personal hygiene, classic Soaps, namely, salts of fatty acids, for various reasons, are no longer the preferred compositions. For example, it is believed that Soaps are relatively aggressive, rude or irritating the skin and eyes, they are not easy to prepare in the form preferred for the consumer compositions, such as gels, they do not light or do not leave the feeling of clean skin after application, especially when the water to wash contains impurities, such as ions, and are not particularly good carriers for delivering agents that have beneficial effects, such as odorants. Especially bad soap are in hard water, forming ions such as ions of Ca, Mg, Mn and Fe, insoluble precipitates, which are very difficult to wash.

On the basis of chemical substances, different from the classic soap, we developed a lot of songs, and most of them include surfactants of various types, also known as synthetic detergents, which are used to solubilize the Mac is l and other pollutants, helping them to rinse with skin in the shower or bath. Widely used composition for personal hygiene, prepared from surfactants, other than salts of fatty acids, which promote good pricing, improve the user's perception of agents that have beneficial effects, such as odorants, have a mild effect on the skin and make nice washing process.

However, many, if not all, of these industrial personal hygiene products contain surface-active substances (surfactants, detergents such as anionic surfactants (detergents)that can be harmful to aquatic organisms, especially in high concentrations, and are prominent components of wastewater, launchable from the premises all over the world. Some of these surfactants (detergents) have a low Biodegradability and, therefore, resistant to the environment. Perfumes (fragrances) (as a rule, chemical mixtures, also called essential oils) are an example of another component of many personal care products that may have poor Biodegradability and can have toxic effects on aquatic organisms exposed to wastewater containing residues of aromatic compounds. The Pris is the effect of these components in selling personal care products leads to the descent of treated or untreated wastewater, containing at least some of the components in streams, rivers, oceans and groundwater, sometimes with disastrous consequences.

The presence of surfactants such as anionic surfactants, and aromatic oils in the re-entry of treated wastewater can be harmful to aquatic organisms in the receiving waters. This effect is more pronounced at higher concentrations of pollutants in the wastewater. The types of organisms that can be affected include useful microorganisms, invertebrates and vertebrates, useful algae and higher plants. Also, if fresh water, where are such wastewater want to use as drinking water, the presence of such contaminants may hinder the efforts required to obtain drinking water. See, for example, the document entitled "Environmental and Health Assessment of Substances in Household Detergents and Cosmetic Detergent Products," Torben Madsen et al., Danish Environmental Protection Agency, Centre for Integrated Environment and Toxicology (CETOX), Environmental Project No. 615, 2001, at http://www2.mst.dk/udgiv/Publications/2001/87-7944-596-9/pdf/87-7944-597-7 .pdf.

The toxicity of aqueous and personal requirements for clean water cause growing concern due to the growing world population and increasing consumption per capita. Many indicator species, such as amphibians, like frogs and salamanders (tailed amphibians), during the last few decades there is a dangerous decrease in populations. Sensitive skin of such animals may be especially sensitive to the effects of surfactants, which uses people in their natural habitat (water). It is also known that surfactants cause problems with waterfowl, removing the natural fat of bird with feathers and making them prone to hypothermia. When the feathers are wet due to the flushing of surface-active substances (surfactants) natural protective skin fat, these birds also impaired the ability to fly. Due to the action of surfactants on the cell membrane pollution they cause a threat to various aquatic invertebrates. On the populations of oysters influence of surfactants falling within the coastal environment from sewage treatment facilities. The presence of surfactants, apparently, causes damage to populations of less conspicuous species, such as insect larvae and single-celled animals.

However, surfactants are extremely widely used among the population for washing and bathing. Frequent bathing and hand washing, etc. is vital to maintaining the health of the population, reducing the spread of pathological organisms and preventing epidemics. Generally people like to be clean and appreciate the purity of other people. Therefore, the use of compositions containing surfactants, are likely to continue. Therefore, it is desirable to develop a cleaning composition for the primary hygiene (wash, personal use)that is acceptable to consumers, but to reduce their impact on the environment when you hit it with the waste water, such as water for washing. Reducing human impact on the ecosystems in which people live, you can improve environmental sustainability without losing valuable and extremely important to the quality of life.

Disclosure of inventions

The present invention relates to compositions adapted for use as detergent compositions (shower or bath), usually called gels, bath or shower, personal hygiene. The compositions of the present invention provide, from the point of view of the consumer, comparable or better cleansing properties and at the same time benefit the ecosystem and the environment in General. Application of the compositions according to the invention instead of the currently used sales standard songs for personal hygiene can lead to a cleaner wastewater with improved environmental profile.

As discussed above, many products for personal hygiene, currently available on the world markets, contain components such as surfactants and aromatic oils (perfumes), which can be sustainable in the wastewater and in the environment and have a certain toxicity to aquatic organisms (aquatox what durability), and can harm the ecosystem in which they are washed off (fall). Prolonged use on a large scale such personal hygiene (personal detergents) can have a harmful effect on a huge variety of organisms that share the planet Earth with man. The use of compounds according to the invention can provide equal or better quality wash for the consumer and at the same time has reduced the harmful effects on the environment caused by the ingress (flushing) surfactants and aromatic (aromatic) compounds (odorants) in waste water.

In some embodiments, the present invention provides compositions and methods that allow the consumer to use the product for personal hygiene, which contribute to the fact that decreases the harmful effects of consumers on waste water and, therefore, pollution of the water environment and harming aquatic organisms around the world. The composition of the invention possess many desired properties of products for personal hygiene, which currently use consumers and with which they are familiar, and provide at least equal to the quality of cleaning, pricing, action flavouring substances, etc. By incorporating in the composition of the invention natural component derived natures the school cellulose, it is possible to obtain a composition, which contains a reduced number of potentially hazardous surfactants and aromatic oils compared to standard modern tools (products) personal care, while maintaining the functional properties that consumers have come to expect. The use of a composition according to the invention instead of contemporary compositions for personal hygiene can reduce the negative impact on the environment while maintaining the other properties that are valued by consumers in personal care products.

In some embodiments, the present invention provides a composition for use as a gel for the bath, means (product) personal hygiene of a person that contains:

(a) no more than about 11.5 wt%. anionic surfactants;

(b) no more than about 3 wt%. zwitterionic surfactant;

(C) not less than about 0.1% weight. derived hydroxyethylcellulose with long-chain alkyl group (long-chain (long) alkyl-hydroxyethylcellulose); and

(g) water,

and, optionally, optionally containing not more than about 2% weight. non-ionic surfactants, or not more than about 3 wt% aromatic oils, or both.

In various embodiments, the composition according to the invention can be in the form of a viscous liquid or gel adapted for use as a detergent, which carried the t their cleaning (washing) function at least as well as a modern sales (commercially available) personal care products, but has a lower percentage of potentially hazardous surfactants and aromatic oils.

In some embodiments of the invention in regard to viscosity, education and the lifetime of the foam, the intensity of the action and stability of aromatic substances, mild action on the skin and a feeling of purity, the composition according to the invention may cause the user the same feeling as when using the selling hygiene products with high concentration of surfactants, aromatic oils, or both, but not containing hydroxyethylcellulose with long-chain alkyl group.

In some embodiments, the invention provides a composition in which an aromatic oil contained in a lower concentration than in comparable composition not containing derivative hydroxyethylcellulose with long-chain alkyl group having a high content of anionic surfactants, the effect of aromatic substances on the skin, the action of aromatic substances in the free space capacity (container), or both, is not less than that of the comparison (control) composition.

In some embodiments of the invention the composition according to the invention provides less toxicity of an aqueous solution, and more in the high degree of decomposition under the action of microorganisms (biodegradation) in the wastewater, when applied in amounts comparable to sales agent (product) personal hygiene, such as shower gel or bath.

In some embodiments, the invention provides use of a composition according to the invention for the preparation of tools (product) personal hygiene.

In some embodiments, the invention provides a method of reducing the surfactant concentration in the waste (wash) waters after a bath or shower, including the application subject to their own washing in the bath or shower a certain amount of the composition according to the invention instead of using comparable amounts comparable composition not containing derivative hydroxyethylcellulose with long-chain alkyl group and having a high content anionic surfactant.

In some embodiments, the invention provides a method of reducing the load of surfactants in a wastewater treatment plant, including the application subject to their own washing in the bath or shower a certain amount of the composition according to the invention instead of using comparable amounts comparable composition not containing derivative hydroxyethylcellulose with long-chain alkyl group and having a high content anionic surfactant.

In some embodiments, the invention provides a method of reducing toxicity of wastewater for Organismo is, contact with wastewater caused by the use for personal hygiene a certain amount of gel for the bath or shower, including the use of the subject for its own wash in the bath or in the shower of an equivalent amount of the composition according to the invention.

In some embodiments, the invention provides a method of increasing the ability to decomposition under the action of the microorganism content of wastewater after use as personal care products in the form of gel for the shower or bath, including application of the subject for its own wash in the bath or in the shower of an equivalent amount of the composition according to the invention.

In some embodiments, the invention provides a method of reducing the amount of aromatic oil, washed wastewater in the ecosystem after applying a certain amount of personal hygiene products in the form of gel for the shower or bath, including application of the subject for its own wash in the bath or in the shower of an equivalent amount of the composition according to the invention.

In some embodiments, the invention provides a method of improving environmental sustainability observed in the use of personal hygiene products in the form of gel for the shower or bath, including application of the subject for its own wash in the bath or in the shower is equivalent to the number of compositions of n the invention.

Brief description of figures

The Figure 1 presents a bar chart (histogram)showing the relative toxicity, identified by the method of the REC, the composition of the bath shower gel compared with the standard composition of the cleansing gel.

The Figure 2 presents a bar chart (histogram)showing the relative cytotoxicity was determined by the method of NO-ITSELF, the composition of the bath shower gel compared with the standard composition of the cleansing gel.

The Figure 3 shows a bar chart (histogram)showing the relative cytotoxicity was determined by the method of NRU, the composition of the bath shower gel compared with the standard composition of the cleansing gel.

The Figure 4 shows a bar chart (histogram)showing the characteristics (properties) of the foam formed in aqueous solution the two compositions according to the invention, in comparison with a standard composition.

The Figure 5 presents a graph of the dependence in time of formation in aqueous solution of the foam composition of the cleansing gel according to the invention in comparison with a standard composition.

The Figure 6 presents a graph of the dependence in time of the destruction of the foam formed in aqueous solution composition of the cleansing gel according to the invention, in comparison with a standard composition.

The Figure 7 shows the ranking score (ranking) su is aktivnogo perception of cleanliness (washing) in a group of 16 users.

In Figures 8 and 9 provides a comparison of actions aromatic substances on the skin and in the free space of the vial above the product, respectively, of the composition of the cleansing gel according to the invention relative to a standard composition for a single aromatic oil.

In Figures 10 and 11 provides a comparison of actions aromatic substances on the skin and in the free space of the vial above the product, respectively, in the composition of the cleansing gel according to the invention relative to a standard composition, averaged over six different aromatic oils.

The implementation of the invention

The expression on this description of the tool (product) personal hygiene" refers to compositions, such as gel for the bath or shower, or liquid ("cleansing gel"), which is used by the person with water for washing, i.e. for washing the body and its sections, for example, in the prescribed manner or daily. The term "bathing (washing)" in this description includes the personal wash (cleansing), carried out in the tub or Jacuzzi with hot water or in a different volume of water, and includes showering in combination with the use of a water stream or spray of water, and also includes sponging wet sponge with water soaked cloth or other absorbent material. The term for this description includes the local wash, is what as washing hands and face, and local wash (hygiene) any other exterior body parts.

The term "cleansing gel" refers to the agent (product) personal hygiene, representing a viscous liquid or gel suitable for dosing (spill) of the consumer packaging, such as plastic or glass vial (bottle) or other capacity, are applied to the skin and mixed with water, forming when washing as described above cleansing foam, then the foam wash, removing oil, grease, soil and pollution of various types. "Gel" in this description may be fluid so that it can be poured from a plastic bottle, pressing her hand, and includes a liquid with a viscosity higher than the viscosity of water.

A means of personal hygiene according to the invention may, but need not necessarily, be Packed in a bottle or in a container for reusable; also included packaging for the consumer in the form of capsules, soft containers (packages), tubes, plastic push feeders, reciprocating feeders, and other types of consumer packaging. In some embodiments of the invention the cleaning gel can be dosed (pour) in any way, used for dispensing flowable compositions for washing. A hygiene product according to this description can also be used to wash children or elderly people who cannot bathemselves,or for bathing Pets, such as dogs or horses.

The term "composition" according to this description, in relation to the composition of this invention or to control the composition, referred to as the specified mixture comprising water, packaged for use and used by the user for cleaning. Accordingly, when in this description to say about the "amount" of the composition, this acknowledgement is given to the quantity, weight or volume, of the composition, which supposedly uses, including water for dilution of the active ingredients. Thus, the "amount" of the composition according to the invention, which has reduced the "content" or "percentage" anionic surfactants compared to the equivalent "amount" control composition, in fact, contains a smaller absolute number of anionic surfactants, although the number of tracks equivalent.

The terms "standard composition" or "control composition" in this description means the composition of the cleansing gel (gel bath), used for comparison with the composition according to the invention in regard to the properties and parameters. Standard or control composition similar variant compositions according to the invention except that it contains a relatively high concentration or has a relatively high content of anionic surfactants or mixtures of anionic surfactants and aroma is practical oils, and it contains no derivative hydroxyalkenals with long-chain alkyl group.

"Surfactant," "surfactant", as is well known in the prior art, means a chemical composition, molecular structure, which has the property to reduce the interfacial surface tension between water and a water-insoluble substances, such as oils or fats. Surfactants can also be effective when suspendirovanie in water solid materials, such as dirt particles. Such substances are also known as "amphiphilic materials," because their molecules provide great education, possessing both hydrophilic and lipophilic properties, which allows them to interact with water and with not miscible with water substances at the interface.

The term "anionic surfactant, surfactant" in this description refers to a surfactant that contains one or more molecular groups that carry a negative electrical charge. Anionic surfactants may contain such a group as sulfate, or phosphate, or carboxyl in anionic form, i.e. existing in aqueous solution at neutral or close to neutral pH in the ionic form. Anionic surfactants also contains a hydrophobic group associated covalent bond with a group (fragment), bearing a negative charge. In affect, the, the term anionic surfactants according to this description includes the alkyl sulphates, sulfonates, carboxylates and the like, with a long alkyl chain. An example is dodecyl sulphate. Another example is sodium Laureth sulphate, i.e. the sulfonated gidroksietilirovanny the dodecanol.. Another example is acylcarnitines (salt of N-(long chain alkanoyl), N-methylglycine). As for the surfactant, anionic surfactants may be called "anionic detergents."

The term "zwitterionic surfactants" ("zwitterionic detergent") according to this description, refers to a surfactant, in which the molecular particle contains both positive and negative electric charge generated in the molecular particles associated covalent bond with a lipophilic group (fragment). Various zwitterionic surfactants contain "betaine", i.e. a group containing carboxyl group (anionic) and Quaternary ammonium group (cationic). An example is cocamidopropylbetaine, i.e. amide of a fatty acid linked through the group with the group of N,N-dimethylglycine so that the nitrogen atom in glycine is Quaternary (cation).

The term "non-ionic surfactants (nonionic detergent)" is a surfactant that does not contain groups ionized in water at neutral or close to neutral pH value, however, are amphipatic containing as limes is a multidisciplinary, and hydrophilic fragments. Examples are esters of fatty acids and Sugars, in which the hydroxyl group of Sugars form a hydrophilic fragment.

"Aromatic oil" or "aromatic compounds", as a rule, are a complex mixture of many molecular components, usually liquid at room temperature, although some of the individual starting materials can be solid at room temperature (mixture) imparts desirable or attractive smell, such as mixtures, are well known in the prior art. Such materials are also referred to as "perfumes, aromatic substances," 'fragrant substances," "essential oils," "SW", etc., These materials consist of a combination of ingredients with a pleasant organoleptic properties, is perceived by a person, and have a separate (single) materials, a complex reaction mixture and natural compounds, usually of plant origin. Examples include various organic compounds, such as octadiene, hexyloxymethyl, derived cyclopentane, diesters dibasic aliphatic acid, 3-(10-undecyloxy)propionitrile, derivatives tricyclodecane-methylol, esters of 2-methyl-2-alkylamino acids, trimethylcyclohexylamine esters, cyanoacetylene, mole(about the)altimeter cyclohexane, nonanol, nonanol, α-examerican, the esters of safronovoi acid and maltol-2-methylalanine (see, for example, Goronszy, M.C. (1992), Treatment of perfume manufacturing wastewaters by co-metabolism with an alcohol substrate, Water Science & Technology 25 (3), 131-141). Examples include lavender oil, rose oil, essence of lilac, the essence of Lily of the valley, etc.

"Long-chain (long) alkyl" group or a derivative refers to a lipophilic fragment or substance, which molecule includes a long-chain, i.e. containing more than 10 carbon atoms, hydrocarbon radicals, such as n-dodecyl, n-hexadecyl and other long-chain alkyl group on this description can include a mixture of various forms of long-chain alkyl, such as those usually obtained from natural sources or as a result of the separation.

Examples of long-chain alkyl include cetyl, i.e. hexadecyl, and lauryl, i.e. dodecyl. The chain may be completely saturated or may contain one or more double bonds (unsaturation), and while it is often linear, and may include waste (branches off, side) groups such as alkyl groups.

"Long-chain alcoolica" group is a long-chain alkyl group bearing at one end of the carbonyl group through which this group is associated with a different group. An example is Carolina group, which are the two who is alkanoyloxy group, and includes a mixture of various long-chain alkyl gruppem unsaturated radical is oleoyl, octadec-9-enoyl.

The term "cellulose" as it is known in the prior art, relates to poly - β(1,4)-D-glucose, usually derived from wood pulp, cotton or other vegetable sources. There is also a cellulose derived from bacteria. "Hydroxyethylcellulose" is a polymer that is formed by the reaction of cellulose or its derivative with epoxide (oxirane), such as ethylene oxide (hydroxyethylcellulose) or propylene oxide (hydroxypropylcellulose). The term "Hydroxyethylcellulose with long-chain alkyl group (long-chain alkyl-hydroxyethylcellulose") according to this description, refers to a substance composed of cellulose molecules, covalently associated with hydroxyalkyl, and long-chain alkyl groups. An example is cetyl hydroxyethylcellulose, i.e. gidroksietilirovanny cellulose, which is reacted with etilovym alcohol (1-hexadecanol). Therefore, hydroxyethylcellulose with long-chain alkyl group (long-chain alkyl - hydroxyethylcellulose) is a polymeric material containing both hydrophilic and lipophilic domains.

The term "viscosity"as is well known in the technical field relates to the density of the sludge is resistance to fluidity of the composition of a liquid or gel.

The expression "soft effect on the skin" refers to the property of a solution of detergent product (hygiene) not to cause irritation or inflammation of the living human skin. Index of cytotoxicity can be used to assess the degree mild action on the skin, as substances that have a beneficial effect on the skin, should have low cytotoxicity.

The term "foam", "foam" refers to the volume, density and length of existence or stability of the suds formed by mixing a solution of detergent in water, for example, when the skin is rubbed by hand or between your hands.

The expression "perception (sensation) wash (hygiene)" refers to the subjective judgment of the person who used the composition in the bath or in the shower, how clean is felt the skin or body of the user after application of the composition and remove the skin.

"The effect of aromatics on the skin" refers to the intensity of the odor residue aromatic substances on living human skin that is felt by the user after application of the composition for washing in the bath or under the shower.

"The effect of aromatic substances in the free space capacity" refers to the perceived user odor aromatic substances (odorants) in free space of the vial Il is another tank, used for storage of the composition, prior to use, i.e. after opening the tank, but before applying the composition.

The term "waste water" refers to water after a shower or bath, which contains the remains of products for personal hygiene, applied by the subject, or to the total discharge of domestic wastewater from one or more premises (residential units)in which people wash in the bath or in the shower, or drain of the device for wastewater treatment, which receives, with sewage effluent from residential premises or other sources containing waste water after personal hygiene.

The expression "toxicity to organisms (organisms)" refers to acute or chronic toxicity of an aqueous solution containing a certain amount (percentage) of the composition, such as composition according to the invention or a control composition (composition comparison)in respect of organisms that usually spend their entire life, or part of life in the aquatic environment or in contact with an aqueous medium. Such organisms include microorganisms, invertebrates and vertebrates that spend their entire life cycle, or part of it, in or near the water, or drink this water; and plants, both unicellular and multicellular organisms that come into contact with the composition, for example, ground water is. Examples of microorganisms include bacteria and protozoa; examples of invertebrates include insects such as insects in the juvenile phase and other multicellular organisms living in the water; vertebrates include fish, amphibians and reptiles that live in the water, and reptiles, birds and mammals that are either floating in the water or drink it. Examples of plants include algae and pure aquatic plants, including algae, which live in water, and land plants, which are subjected to water contact with groundwater, irrigation, etc. it is Known that anionic surfactants, such as, among others, surfactant-based sulfates, in some concentrations have a damaging effect on living organisms, for example, preventing normal operation of the cell membranes, etc.

The term "biological degradation" refers to the destruction of the chemical components of the composition in the natural environment, such as water ecosystem, which is discharged waste water containing effluent, under the influence of natural factors, such as bacteria, fungi or photochemical mechanisms, etc. This term in this description means that when the biological decomposition of the chemical component does not necessarily have to turn into carbon dioxide and water, but at least a component which n is which toxicity, must be transformed using a natural mechanism or process, the compound or compounds with less toxicity.

The expression "reducing surfactant-load in the waste water and reduce the concentration of surfactants in waste water" refer to the reduction or decrease in the concentration of a single surfactant, or the total set of surfactants, depending on the context, in the flow of waste water (sewage water), such as treated waste water from the house or other residential premises (residential units), or treated waste water from the unit for water purification. The expression "load reduction of aromatic oils in waste water and reduce the concentration of aromatic oils in waste water" refer to the reduction or decrease in the concentration of one aromatic oils or comprehensive set of essential oils, depending on the context, in the flow of waste water (sewage water), such as treated waste water from the house or other residential premises (residential units), or treated waste water from the unit for water purification. The phrase "stream of treated wastewater" means the flow of escaping from the unit (structure) for the treatment of sewage that enters surface waters, such as streams, rivers, lakes and the ocean.

The expression "improvement of environmental sustainability" in this description refers to the holding of the superior is th, such as reduced toxicity, increased biological decomposition such as purified water, high purity water, released into the environment, and thereby to maintain the sanitary condition of the environment (ecomedicine) and reduce the potential irreversible depletion of biological sources, such as aquatic plants, animals and microorganisms.

In some embodiments, the invention relates to compositions adapted for use as a cleansing gel for personal hygiene of the person. The composition according to the invention, while retaining certain properties that are valued by consumers and users of detergents (hygiene), at the same time have benefits for the environment, compared with other types currently available on the market for personal hygiene. The authors of the present invention (s) unexpectedly found that it is possible to prepare compositions with a low concentration of potentially hazardous to the environment of the ingredients by adding a class of additives derived from natural cellulose polymer that (song) still retain the desired properties, such as viscosity, pricing, feeling clean, users, beneficial agents, such as aromatic oils, and soft effect on the skin. Replacement parts is potentially dangerous to E. the sociology of anionic surfactants and aromatic oils derived hydrocellulose with long-chain alkyl substituent in the gels for bath (washing gels) can provide a means of personal hygiene with improved environmental profile.

In some embodiments, the present invention provides a composition for use as a gel for the bath, means (product) personal hygiene of a person that contains:

(a) not more than about 11.5 wt%. anionic surfactants;

(b) not more than about 3 wt%. zwitterionic surfactant;

(C) not less than about 0.1% weight. derived hydroxyethylcellulose with long-chain alkyl group as a substituent (long-chain (long) alkyl-hydroxyethylcellulose); and

(g) water,

and, optionally, optionally containing not more than about 2% weight. non-ionic surfactants, or not more than about 3 wt% aromatic oils, or both.

In some embodiments, the composition according to the invention is in the physical state viscous liquid or gel at room temperature. Viscosity is also affected by the concentration of surfactant (detergent or detergent) in the composition On the viscosity can also be affected by the presence of salt in the form of supplements, although in comparing the compositions of the salt is either absent or its salt is contained in a certain concentration (e.g., NaCl), a some options for the composition of the invention is similar in regard to the physical condition in the form of a gel or viscous fluid, comparable to the composition, which has a higher total concentration of anionic (anionic) surfactants and aromatic oils, and surfactants other type is in, but does not contain a derivative hydroxyethylcellulose with long-chain alkyl substituent.

In some embodiments of the invention the composition may include no more than about 11.5 wt%, or no more than about 10% weight, anionic surfactant or a mixture of several (more than one) anionic surfactants. More specifically, the composition may include no more than about 9 wt%, or no more than about 8 wt%, or not more than 7 wt%, anionic surfactants or a mixture of several (more than one) anionic surfactants, in combination, approximately not less than 0.1% derived hydroxyethylcellulose with long-chain alkyl substituent.

In some embodiments of the invention the composition according to the invention as a component of the anionic surfactants may contain salt alketh sulfate (acesulfam?), acylcarnitines or any combination of them. More specifically, anionic surfactants in the compositions according to the invention may contain sodium Laureth sulphate, lauroylsarcosine sodium or kakailanganin sodium, or any combination of them.

In some embodiments of the invention the composition according to the invention may contain not more than about 2.4 wt% zwitterionic surfactant. For example, the composition may contain zwitterionic surfactant component comprising amidoalkylation fatty acids, such as cocamidopropylbetaine.

In some embodiments of the invention the composition according to the invention may contain the e more about 0.5 wt% nonionic surfactant. In some embodiments of the invention the composition according to the invention can contain non-ionic surfactants, including monoglycoside or polyglucoside fatty alcohols or any mixture. More specifically, glucoside fatty alcohol can be cocoglucoside.

In some embodiments of the invention the composition according to the invention can contain less than about 0.1 wt%, or 0.2 wt%, or 0.3 wt%, or 0.4 wt%, or 0.5 wt%, derived hydroxyethylcellulose with long-chain alkyl substituent. More specifically, the derived hydroxyethylcellulose with long-chain alkyl group (Deputy) may represent cetyl hydroxyethyl cellulose. As is well known in the prior art, examples of derivatives hydroxyethylcellulose with long-chain alkyl group can be variable molecular weight (average and srednekamennogo), a variable degree of polymerization hydroxyethylene component and a variable number of substitute groups-long-chain alkyl component. More specifically, an example is Natrosol Plus Natrosol Plus 330 CS®, manufactured by Hercules, Inc.

In some embodiments of the invention the composition according to the invention can additionally contain additives well known in the prior art, such as rheology modifiers or natural, ribosylating origin, as thickeners or suspendida agents, for example, or natural polysaccharides, such as xanthan gum, GVWR, chitosan, guar gum or derivatives thereof, or synthetic polymers such as polyacrylates, polyvinyl polymers, polymethacrylates, polyamides or their derivatives; improvers physical properties (air conditioning) polymers of natural or synthetic origin, such as Quaternary ammonium salt of acrylamide and dimethyldiallylammonium (Polyquatemium-7, Polyquaternium-7), the Quaternary ammonium salt is a reaction product of hydroxyethyl cellulose with trimethylammoniumphenyl the epoxide (Polyquatemium-10, Polyquaternium-10), Quaternary ammonium derivative and hydroxypropylamino the like; moisturizing agents, i.e. agents that bind water, such as polyols (polyalcohol), for example, glycerol, propylene glycol and the like; preservatives such as organic acids, for example, sodium benzoate; antioxidants, such as Tocopherols and their derivatives; and pH correctors, such as sodium hydroxide, lactic acid, citric acid and their salts. Other additional components may include vitamins, such as vitamin C, D or E; softeners such as petrolatum, glycerin and the like; plant extracts, non-aromatic substances, such as aloe extract (polysaccharides), glycyrrhizin, oil seed of the Shea tree, proteins or amino acids (protein hydrolysates); sterols, such as ruscogenin, disastery and sitosterol; terpenes, such as squalene; tannins and lignans (e.g., green tea, bamboo); and so on

In some embodiments of the invention the composition according to the invention may include about 0.5-3.0 wt%. aromatic oils or mixtures of various aromatic oils, chosen to ensure value for the consumer organoleptic profile. For example, the composition may contain no more than about 1.0 wt%, or no more than about 2.0 wt%, or not more than about 3.0 wt%, aromatic oils or mixtures of such oils.

In some embodiments of the invention the composition according to the invention can contain

(a) not more than about 8.0 wt%. anionic surfactants;

(b) no more than about 2.4 wt%. zwitterionic surfactant;

(C) not less than about 0.3 wt%. derived hydroxyethylcellulose with long-chain alkyl Deputy; and

(g) water;

not necessarily, additionally containing about 3% weight. aromatic oils;

moreover, the composition is in the form of a viscous liquid or gel at room temperature.

For example, the composition may contain no more than about 0.3 wt%. non-ionic surfactants, preferably, Alkylglucoside fatty alcohols, more preferably, cocoglucoside.

In some embodiments of the invention HDMI is tion according to the invention can be a composition, the viscosity is at least the same as the viscosity of the comparison (control) composition not containing derivative hydroxyethylcellulose with long-chain alkyl substituent and having a higher content of anionic surfactants or oils, or both.

For example, the composition according to the invention, containing the ingredients in a weight percentage in the range presented in below in Table 1, may have a comparable or higher viscosity than standard gel composition for a shower or a bath, such as is shown in Table 2. Some variants of the invention may have a composition containing components in the range presented in Table 1. The total concentration of anionic surfactants, contributing to the viscosity of the sample is no more than about 8 wt%.

Table 1
A typical composition according to the invention
Component% the weight.

WaterAbout 85-90
Anionic surfactants based on sulfate6.5-8.0
Zwitterion SAS 1.5-3.0
Non-ionic surfactants0.15-1.0
Hydroxyethylcellulose with long-chain alkyl group0.2-0.5
Aromatic substance0.5-2.5
Other componentsrest

For example, the composition of the gel for bath (washing gel) according to the invention may include about 7% sodium Laureth sulphate, about 2.4% of cocamidopropylbetaine, about 0.2% of cocoglucoside, about 0.3% of cetil of hydroxyethyl cellulose and about 1% of aromatic oil.

Table 2
Typical control track
Component% the weight.
WaterAbout 82-84
Anionic surfactants based on sulfate14.2
Zwitterion SAS1.8
Non-ionic surfactants0.8
Hydroxyethylcellulose with long-chain alkyl group -
Aromatic substance0.5-2.5
Other componentsrest

It turned out that the composition shown in example according to the invention, are shown in Table 1, including the agent, which have a beneficial effect (aromatic oil), and not containing NaCl or other inorganic salt has a viscosity 55.6 CP at 25°C. at a speed of 100 Brookfield viscometer spRv3. It was found that the viscosity of the control composition not containing NaCl or other inorganic salts)that have a higher content of anionic surfactants, but not containing hydroxyethylcellulose with long-chain alkyl group, such as the one shown above in Table 2, including the agent, which have a beneficial effect (aromatic oil), in the same conditions is 17.7 CP.

In some embodiments, the invention provides a composition with a soft effect on the skin, and this soft effect is the same as that of the control composition that does not contain a derivative hydroxyethylcellulose with long-chain alkyl group and having a high content anionic surfactant and may also, aromatic oils. In Figures 1-3 shows the results in comparison with results for the composition of izopet the tion.

Figure 1 compares the index of cytotoxicity, a specific method of analysis of the recovered cultures of epithelial cells (Reconstituted Human Epithelial Culture (REC)), the composition containing (left to right) control (detergent) gel for the bath without aromatic oils (EO) and aromatic oil, compared with (wet) gel for the bath according to the invention without aromatic oils (EO) and aromatic oil. The composition of the gel according to the invention compared with the control, but contains about 15 to 25% less aromatic oils. Figure 2 compares estimates of irritants in the test for chorioallantoic membrane of the chicken embryo (NO, the test ITSELF, the HET-CAM test) for compositions containing (left to right) control (detergent) gel for the bath without aromatic oils (EO) and aromatic oil, compared with (wet) gel for the bath according to the invention without aromatic oils (EO) and aromatic oil. The Figure 3 gives the comparison of the index of cytotoxicity, by definition, method of neutral red uptake (NRU) (spectral analysis), the composition containing (left to right) control (detergent) gel for the bath without aromatic oils (EO) and aromatic oil, compared with (wet) gel for the bath according to the invention without aromatic oils (EO) and aromatic oil. Each of these comparisons p is found, the composition according to the invention works as well as or better than the control composition in these analyses, each of which is an indicator (characteristic) mild action on the mucous membrane or high (good) tolerance to the eye.

In some embodiments, the invention provides a composition in which the pricing when applying (soaping) of the composition to the skin of the user at least the same as the pricing benchmark (compare) the composition does not contain a derivative hydroxyethylcellulose with long-chain alkyl group and having a higher content of anionic surfactants, when applied to the skin (soaping skin of the user in comparable conditions.

Figure 4 graphically shows the results of evaluation of properties (behavior) foam two compositions gel for bath (washing gel) according to the invention ("LS NAR SGel" and "LS NAR SGel Improved) compared with the control cleansing gel (gel bath) ("Std. SGel", "Standard SGel"), not containing derivative hydroxyethylcellulose with long-chain alkyl substituent and has a high (>11.5%) of the total concentration of anionic surfactants. From this estimate it follows that the action of the two detergent compositions of the gels (gels for bath) according to the invention at least almost the same as the action of the control gel. The evaluation was performed using m the TOD C-TP-1494/1-Mod, the product concentration in water of 1 g/l, sample volume 200 ml, T=25°C±1°C, the total number of shaking 10, measurement time: time 0 min (education) and 15 min (destruction).

In Figures 5 and 6 graphically shows the results obtained with the use of SITA Tester foam R-2000, comparing pricing and destruction of foam for the composition of the cleansing gel according to the invention ("LS-HFP gel composition for a shower") and for the control compositions ("standard composition of shower gel). The test composition: concentration of 7 g/l in deionized water, the sample volume 250 ml, T=35°C±1°C, rotor speed 950 rpm, mixing time 10 sec, total time 8 min (education), 7 min (destruction). As you can see, a variant of the composition of the cleansing gel according to the invention at least the same degree provides education and foam stability, as well as the standard composition control cleansing gel.

In some embodiments, the invention provides a composition and a positive perception (positive evaluation) cleaning of the subject using the composition, of at least the same as perception (positive evaluation) cleaning the comparable composition not containing derivative hydroxyethylcellulose with long-chain alkyl group and having a higher content of anionic surfactants. In Figure 7 is provided a subjective assessment of perception (sensation) cleanliness (washing) on the basis of the results, retrieved on 16 volunteers, variant compositions according to the invention compared with the standard reference composition of the cleansing gel. As you can see, there was no reduction of the positive feeling of cleanliness (washing)experienced by users of the composition according to the invention, in comparison with standard composition.

In some embodiments, the invention includes a composition comprising, approximately, up to 3 wt%. aromatic oils or about 2%or about 1%, the effect of aromatic substances on the skin, the action of aromatic substances in the free space capacity (container), or both, is not less than the equivalent operation compared (control) composition. In Figures 8 and 9 compare variant compositions according to the invention with a control cleansing gel, with equal concentrations of essential oils (EO), about 1-1 .3% weight. in education, for one aromatic oils on the skin and in the free space of the vial. The effect of aromatic substances determined by the method of solid phase microextraction (SPME). As you can see, "the basis of gel LS HFP (composition according to the invention) shows the effect of aromatics on the skin at time 0 and 3 hours, and in the free space of the vial, which exceeds the effect of the composition of standard cleansing gel - source cleansing gel."

On the hurah 10 and 11 provides a similar comparison of the action of aromatic oils on the skin and in the free space of the vial except the concentration of aromatic oils in the compositions according to the invention, approximately 15-25% lower, and the data represent the average of results obtained by SPME for six different aromatic oils. Again, "the basis of gel LS HFP (composition according to the invention) shows the effect of aromatics on the skin at time 0 and 3 hours, and in the free space of the vial, which exceeds the effect of the composition of standard cleansing gel - source cleansing gel."

In some embodiments, the invention includes a composition, a number of which in water is less toxicity to organisms in contact with water than the equivalent amount of the composition of the comparison (control composition that does not contain a derivative hydroxyethylcellulose with long-chain alkyl group and having a higher content of anionic surfactants. Comparison of the profile of the relative toxicity of an aqueous solution derived hydroxyethylcellulose with long-chain alkyl group with anionic alketh (alcet) surfactants is given in Table 3.

Definition of common terms is given below:

LC50 or EC50: Lethal or effective concentration 50 = Concentration in water, 50% probability of harmful effects on aquatic flora and fauna, or causes the death of 50% of the aquatic flora and fauna.

SFacute(SFOST is th ): Safety factor defined investigated next trophic levels (fish, crustaceans, algae) (the greatest, the best studied) (according to the results of acute tests on animals)

TFacute(TFacute): L(E)C50/SFacute

NOEC: Effect concentration no observed = the Highest concentration for which the difference with the control group is not statistically significant in the long-term study.

SFchronic(SFchronic): Safety factor defined investigated next trophic levels (fish, crustaceans, algae)

TFchronic: NOEC/SFchronic

Table 3
Acute and chronic aquatoxicity cetyl hydroxyethyl cellulose compared to Alketh sulfate surfactant
Acute toxicity (trophic levels of the aquatic biocenosis)Chronic toxicity (trophic levels of the aquatic biocenosis)
LC50 or EC50SFacuteTFacuteNOECSFchronicTFchroni
With 12/15 And 1-3 EO sulfate4.110000.00410.1100.01
Cetyl hydroxyethylcellulose1000100000.16001006

Obviously, the reduction of a few percent concentration of anionic surfactant in combination with the addition of cleaning gel of about 0.1-0.5 wt%. cetyl hydroxyethyl cellulose results in a cleansing gel, showing less aquatoxicity (to aquatic flora and fauna) per unit weight (mass) or volume of the composition in the sales package for use by the consumer. Anionic surfactant has a significantly higher both acute and chronic aquatoxicity than cetyl hydroxyethylcellulose, and the reduction relative to the volume of this material with a relatively high aquatoxicity, and its replacement by a smaller amount significantly less aquatoxics product reduces the overall aquatoxicity the composition of the invention relative to the comparable control the composition of the cleansing gel. The above valuable for pot is ebytes properties, equal to or greater than property sales detergent gels, allow the user to select for washing equivalent volume of product, as it will not cause (stimulus) use more volume to achieve the action (properties), for example, foam or a feeling of purity wash, beyond what is achieved when using the sales of the product.

In some embodiments, the invention includes a composition, characterized in that a large proportion of this composition is biodegradable in waste water or in an aquatic ecosystem in comparable conditions than the share of undergoing biological decomposition in the comparison (control) composition not containing derivative hydroxyethylcellulose with long-chain alkyl group and having a higher content of anionic surfactants.

In some embodiments, the invention includes a method of reducing the surfactant concentration in the waste water (sewage) after a bath or shower, consisting in the use of entity for personal washing (personal hygiene) in the bath or shower a certain amount of the composition according to the invention instead of using a comparable number comparison (control) composition not containing derivative hydroxyethylcellulose with long-chain alkyl group and having a higher content of anionic surfactants.

In some Islands Ianto the invention includes a method of reducing the load of surfactants in wastewater treatment plants, consisting in the use of entity for personal washing (personal hygiene) in the bath or shower a certain amount of the composition according to the invention instead of using a comparable number comparison (control) composition not containing derivative hydroxyethylcellulose with long-chain alkyl group and having a higher content of anionic surfactants.

In some embodiments of the invention the detergent composition of the gel according to the invention retain the diversity of functional properties (technical characteristics), which is no worse, and in some cases much better than the standard properties of the composition of the cleansing gel, such as viscosity, soft effect on the skin, foaming, user perceived sense of purity of washing and the effect of aromatic oils, but contain much less anionic surfactants. As discussed above, reduction of the concentration of anionic surfactants in combination with retention of desirable consumer functional properties comparable or higher level allows the user to use a comparable amount of cleansing gel according to the invention, and it is comparable to the number contains a smaller absolute amount of surfactant. Consequently, the waste water after washing with the detergent composition of the gel according to the invention has a lower concentration and lower General who recalls the surfactant compared with waste water after washing standard detergent gel.

Typically, the waste streams (wastewater) or served in the waste water disposal system for the primary and sometimes secondary treatment in sewage treatment plants, whence come into surface water or disposed of in house systems septic tanks arrive in the soil and groundwater. Accordingly, in some embodiments, the invention provides that the decrease in surfactant concentration in the drains for waste water after bathing or decrease in surfactant-load in the drains for waste water can bring environmental benefits to the ecosystem, which enters the waste water. In particular, if the effluent from wastewater treatment or after the septic tank is relatively high local concentrations in surface or groundwater, the cumulative reduction in surfactant-load as a result of applying for washing compositions according to the invention can have a significant positive impact on the health of the ecosystem. For example, the discharge of waste water having a reduced concentration of relatively toxic anionic surfactants, from devices for waste water treatment in wetlands (too moist) of land will lead to reduced toxicity towards aquatic organisms, the resulting reset. It is known that the health of wetlands is vital the La preserve intact, intact ecosystems, as too many sensitive ecology of the species depend on clean water in the environment on wet lands. This ecological benefits can translate into improved human health in the same way in which people consume products with wetlands, such as various cultivated plants, slave, waterfowl, etc.

In some embodiments, the invention provides a method of improving environmental sustainability, namely, that instead of using as a means of personal hygiene gel for the shower or bath containing a certain amount of one or more anionic surfactants, as a means of personal hygiene use shower gel or bath containing a smaller amount of one or more anionic surfactants and optionally containing at least about 0.1% of a derivative of hydroxyethyl cellulose with long-chain alkyl Deputy, preferably, cetyl hydroxyethyl cellulose. Reducing stress regarding the toxic components of the compositions of the cleansing gel on wastewater, and thereby improving the health of aquatic habitats and subsurface (ground) water, where does the treated (or untreated) wastewater achieve a smaller impact on the environment without compromising the quality of life of people through the use of environmentally besure the aqueous detergent gel of the present invention.

In some embodiments of the invention, the composition or method according to the invention can be any of any combinations and/or "subcommunity" of the above-described variants of the invention.

Although the invention is described and explained in sufficient detail for specialists in this field of technology in order to implement and apply, for a specialist in this field of technology are obvious different ways, modifications and improvements without departure from the essence and scope of the invention presented in the claims.

All patents and publications referenced in this description are included in the present invention by reference to the same extent as if specifically and individually indicated that each publication is included as a reference.

Used terms and expressions are used as terms to describe, but not to limit, and not assume that the use of such terms and expressions to exclude any equivalents shown and described signs or portions thereof, but it is recognized that the amount claimed in the claims various modifications are possible. Thus, it is understood that although the present invention specifically disclosed with the preferred variants and optional features, the experts in this is blasti techniques can resort to modifications and variants ideas, disclosed herein, and that it is intended that such modifications and variations are included in the scope of the present invention defined by the attached claims.

1. Composition for application by the user as a means of personal hygiene in the form of gel for the shower or bath, including:
(a) not more than 11.5 wt.% anionic surfactants, representing alket sulfate, salt acylcarnitines or any combination of them;
(b) not more than 3 wt.% zwitterionic surfactants representing amidoalkylation fatty acids;
(C) not less than 0.1 wt.% derived hydroxyethylcellulose with long-chain alkyl group; and
(g) water.

2. The composition according to claim 1, which at room temperature is in the state of a viscous liquid or gel.

3. The composition according to claim 1, containing not more than 10 wt.% anionic surfactants.

4. The composition according to claim 1, in which the anionic surfactant is a Laureth sulfate, lauroylsarcosine sodium or cocommercial sodium, or any combination of them.

5. The composition according to claim 1, containing not more than 2.4 wt.% zwitterionic surfactant.

6. The composition according to claim 1, in which amidoalkylation fatty acid is cocamidopropylbetaine.

7. The composition according to claim 1, additionally containing not more than 0.5 wt.% non-ionic surfactants.

8. The composition according to claim 7, in which the nonionic surfactant is a m is nonglucose fatty alcohol or a polyglucoside fatty alcohol, or any combination of them.

9. The composition according to claim 8, in which the glucoside fatty alcohol is cocoglucoside.

10. The composition according to claim 1, containing not less than 0.3 wt.% derived hydroxyethylcellulose with long-chain alkyl group.

11. The composition according to claim 1, in which the derived hydroxyethylcellulose with long-chain alkyl group represents cetyl hydroxyethyl cellulose.

12. The composition according to claim 1, containing:
(a) not more than 8 wt.% anionic surfactants;
(b) not more than 2.4 wt.% zwitterionic surfactant;
(C) not less than 0.3 wt.% derived hydroxyethylcellulose with long-chain alkyl group; and
(d) water, and the composition at room temperature is in the state of a viscous liquid or gel.

13. The composition according to item 12, further containing not more than 0.3 wt.% nonionic surfactants, preferably fatty Alkylglucoside (Alkylglucoside fatty alcohol), more preferably of cocoglucoside.

14. The composition according to item 12, having a viscosity of at least the same as the viscosity comparable (control) composition not containing derivative hydroxyethylcellulose with long-chain alkyl group and having a higher content of anionic surfactants.

15. Composition according to any one of claims 1 to 13, which affect the skin in at least the same soft effect that is comparable (control) comp the position, contains no derivative hydroxyethylcellulose with long-chain alkyl group and having a higher content of anionic surfactants.

16. Composition according to any one of claims 1 to 13, which causes at least the same foam as the foam is comparable (control) composition not containing derivative hydroxyethylcellulose with long-chain alkyl group and having a higher content of anionic surfactants, when applied to the skin of the user in comparable conditions.

17. Composition according to any one of claims 1 to 13, which causes the subject using the composition, of at least the same feeling of purity wash as comparable (control) composition not containing derivative hydroxyethylcellulose with long-chain alkyl group and having a higher content of anionic surfactants.

18. Composition according to any one of claims 1 to 13, containing up to 3 wt.%, or up to 2%, or 1% aromatic oils in which the action of aromatic substances on the skin, the action of aromatic substances in the free space capacity (container), or both not less (not weaker)than the effect of aromatic substances on the skin or in the free space of the vessel (container) in comparable (control) composition not containing derivative hydroxyethylcellulose with long-chain alkyl of groppoli having a higher content of anionic surfactants.

19. The composition according to p, in which the aromatic oils present in lower concentrations than in comparable control composition that does not contain a derivative hydroxyethylcellulose with long-chain alkyl group and having a higher content of anionic surfactants, and in which the action of aromatic substances on the skin, the action of aromatic substances in the free space capacity (container), or both, is not less (not weaker)than the effect of aromatic substances on the skin or in the free space of the vessel (container) in comparable (control) composition not containing derivative hydroxyethylcellulose with long-chain alkyl group, and having a higher content of anionic surfactants.

20. Composition according to any one of claims 1 to 13, in which the water is less toxicity to organisms in contact with water than an equivalent amount comparable (control) composition not containing derivative hydroxyethylcellulose with long-chain alkyl group and having a higher content of anionic surfactants.

21. Composition according to any one of claims 1 to 13, which in waste water or in an aquatic ecosystem in comparable conditions biodegradable subjected to a greater degree than undergoing biological decomposition of the comparison (control) composition not containing derivative hydroxyethylcellulose with long-chain alkyl group and having a higher content of anionic surfactants.

22. The use of a composition according to any one of claims 1 to 13 for the preparation of personal care products.



 

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FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to neurology and neurophysiology, therapy and gerontology, and concerns treating chronic cerebral ischemia. That is ensured by adding the food ration with the foodstuff 'Samarskiy Zdorovyak' in a daily dose of 180 g, three times a day 60 g per one intake - with breakfast, lunch and dinner with underlying common ethiopathogenetic drug therapy .

EFFECT: method provides higher clinical effectiveness in chronic cerebral ischemia ensured by better pharmacodynamics and pharmacokinetics of the drug preparations used in treating the given disease that in turn promotes normalising the vasoactive, neurometabolic and neuroprotective brain functions.

FIELD: medicine.

SUBSTANCE: invention refers to cosmetic and pharmaceutical industry and represents a method for improving the transdermal permeability of therapeutic or cosmetic topical preparations involving the dermal administration of 1.0 to 300.0 vol. % of liquid xenon as a part of an acceptable neutral carrier or a therapeutic or cosmetic preparation.

EFFECT: invention provides the higher therapeutic or cosmetic effectiveness ensured by improving the transdermal transport of bioactive compounds.

8 cl, 13 ex, 4 dwg

FIELD: medicine.

SUBSTANCE: invention refers to medicine, and aims at treating acute pyelonephritis in children. The method involves a combination therapy with antibacterial and antioxidant preparations. That is ensured by measuring the pre-therapeutic generation of active oxygen forms (AOF) by whole capillary blood leukocytes using luminol-dependent chemicoluminescence stimulated by barium sulphate crystals, and serum antioxidant content (AOC) by chemicoluminescence activated by rhodamine G in the presence of ferrous iron ions. If the AOF level is more than 2.70×105 quanta/s × 4π, the AOC level is below 29 relative units, a combination therapy with an antibacterial preparation and Canephron N in an age dosage is prescribed for 14 days. On the 14th therapeutic day, the AOF and AOC levels are determined in the patients receiving the combination therapy. If the AOF level is below 2.70×105 quanta/s × 4π, and the AOC level is above 29 relative units, the therapy is terminated. If the AOF level is more than 2.70×105 quanta/s × 4π, the AOC level is below 29 relative units, the Canephron N therapy is continued in the age dosage for another 14 days.

EFFECT: method is simple and high-effective in treating acute pyelonephritis in children.

3 ex

FIELD: medicine, oncology, amino acids.

SUBSTANCE: invention relates, in particular, to the development of an antitumor preparation based on natural substances. Invention relates to an amino acid preparation comprising at least one modified essential amino acid obtained by treatment of amino acid by ultraviolet radiation (UV) at wavelength 250-350 nm for 12-80 h at temperature 15-30oC or with ozone at temperature 15-25oC. The modified amino acid has no toxicity for health cells. Also, invention relates to a method for preparing such preparation. Invention provides the development of an antitumor preparation based on modified amino acids and expanded assortment of antitumor preparations being without cytotoxicity for normal cells.

EFFECT: valuable medicinal antitumor properties of preparation.

8 cl, 4 tbl, 2 dwg, 4 ex

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