Biomechanical stimulation of collagen synthesis in skin cells and reduction of skin small lines and wrinkles

FIELD: medicine.

SUBSTANCE: invention represents a method for biomechanical stimulation of collagen synthesis in skin cells and reduction of skin small lines and wrinkles involving: (a) forming a polymer composition containing a first polymer and a second polymer that are dissolved or dispersed in a solvent system containing water, wherein the above first polymer represents a water-soluble or water-dispersible anionic polymer able to be reduced after solvent evaporation, and wherein the above second polymer represents a water-soluble or water-dispersible cationic polymer able to form a polymer complex able to bind to a skin surface, (b) applying the polymer composition on a first skin region and a second skin region, wherein the first and second regions are separated from each other at a specified distance by at least one small line or wrinkle in between; and (c) drying the polymer composition in the first and second skin regions in the first and second skin regions so that water evaporates in the solvent system and the polymer composition is initiated to be reduced in the first and second skin regions, wherein the above reduction creates a tension over the skin surface between the first and second regions; the tension provides the biomechanical stimulation of collagen in skin cells and reduction of skin small lines and wrinkles.

EFFECT: invention provides the biomechanical stimulation of collagen in skin cells and reduction of skin small lines and wrinkles.

16 cl, 7 dwg

 

The SCOPE TO WHICH the INVENTION RELATES.

The present invention relates to a method of applying a polymer composition onto the skin in such a way as to create surface tension across the width of the skin that mimics the mechanical tension that is found in young skin, thereby biomechanically stimulating the synthesis of collagen and reducing the appearance of fine lines and wrinkles on the skin.

BACKGROUND of the INVENTION

Mechanical forces are important regulators for maintaining proper functionality of the skin. The cells of the skin can feel the tension (i.e., deformation) in the extracellular matrix (ECM)caused by mechanical stresses, and transmit this information to adaptive responses, such as, for example, increase or decrease production of the protein, through the mechanism of feedback and response. Between skin cells and the ECM there is a permanent relationship, and cellular responses to mechanical strain or stress is generated within a fraction of a second through a 3-stage process, which includes mechanosensitivity stage, mechanotransduction and mahaarachchi. When the ECM affects the external tension, it causes exposure to biologically active kryptofix sites in the ECM, which in turn starts the Assembly of the matrix ECM in the extracellular environment. In particular, the Assembly of the matrix ECM includes the involvement of p is slichnih matrix proteins in affected areas ESM, involvement and broadcast integrins, restructuring/tension of the matrix caused by the power of the inclusion matrix functionalities and similar processes. External tension also affects the areas of adhesion between the ECM and the cell of the skin, which leads to structural reorganization and distribution of signals from sites of adhesion to the cell nucleus. In response, the cell changes the levels of protein expression and corrects cellular functions to adapt to changes in the intracellular environment.

As people get older, the skin in General loses mechanical tension. Collagen fibers in the skin are responsible for the provision and maintenance of mechanical tension, which in turn controls the functions of fibroblasts, and Vice versa. A sufficient amount of mechanical tension or stress plays a key role in maintaining a balanced production of proteins and proteases fibroblastlike cells. However, the absence of mechanical tension in aged skin causes the collapse fibroblastic cells. Collaboratories fibroblastlike cells tend to produce less collagen and more collagenase, which in turn leads to a further reduction of the mechanical tension in the skin. In other words, it is a vicious circle, which accelerates the aging process of the skin.

The present invention is to enable the development of a method of biomechanical stimulation of the synthesis of collagen and reduce the appearance of fine lines and wrinkles on the skin by providing the mechanical tension of the skin to simulate natural mechanical tension, found in young skin.

SUMMARY of the INVENTION

The present invention relates to a method of biomechanical stimulation of collagen synthesis in skin cells and reduce the appearance of fine lines and wrinkles in the skin, including:

(a) forming a polymeric composition comprising a first polymer and a second polymer, which is dissolved or dispersed in a solvent system containing one or more solvents, where the first polymer is an anionic polymer, is able to decrease after evaporation of the solvent, where the second polymer is a cationic polymer capable of forming a polymer complex with the first polymer and simultaneously contact the surface of the skin;

(b) applying a polymer composition onto the first area and the second area on the skin where the first and the second region are separated from each other by a specified distance, at least one fine line or wrinkle between them; and

(c) drying the applied resin composition in the first and second areas on the skin, so that happened evaporation of one or more solvents in the solvent system and was initiated by the reduction of the polymer compositions in the first and second fields,

where the reduction creates a mechanical tension on the skin surface between the first and second regions that f is nctional for biomechanical stimulation of collagen synthesis in skin cells and reduce the appearance of fine lines or wrinkles on the skin.

The present invention also relates to a cosmetic device, including:

a housing including a first compartment, a filled polymer composition comprising a first polymer and a second polymer, which is dissolved or dispersed in a solvent system containing one or more solvents, where the first polymer is an anionic polymer, is able to decrease after evaporation of the solvent, where the second polymer is a cationic polymer capable of forming a polymer complex with the first polymer and simultaneously contact the surface of the skin; and

head first applicator located at the end of the housing, and through the fluid chamber connected with the first compartment, where the head of the first applicator is designed for feeding a polymer composition to the skin surface for the formation of an elongated strip having a width in the range from about 2 mm to about 2 cm

In a preferred, but not required embodiment of the present invention, the housing further includes a second compartment filled with a cosmetic composition containing at least one active ingredient, a biologically capable of stimulating the synthesis of collagen in the skin cells and reduce the appearance of fine lines and wrinkles on the skin, and the device further includes W is the ROI the head of the applicator, located at the other, opposite end of the housing and is communicated through the fluid from the second compartment. The second applicator head is designed to supply cosmetic compositions to the skin surface in the form of lines having a width in the range from about 0.1 mm to about 2 mm

The present invention additionally relates to compositions for topical application containing:

(a) from about 20% wt. up to about 40% of the mass. the first polymer selected from the group consisting of polystyrenesulfonate sodium styrene/acrylate/methacrylate ammonium copolymer of vinylcaprolactam/vinylpyrrolidone/dimethylaminoethylmethacrylate, copolymer of vinylpyrrolidone/dimethylaminoethylmethacrylate, copolymer of vinylpyrrolidone/dimethylaminoethylmethacrylate and copolymer dimethylacrylamide/acrylic acid/politicalintelligence;

(b) from about 1% wt. up to about 20% of the mass. a second polymer selected from the group consisting of a copolymer of polyfactorial with butylmethacrylate, copolymer of vinylpyrrolidone/dimethylaminoethylmethacrylate/ methylenedioxymethamphetamine, copolymer of vinylpyrrolidone /metallicametallicametall, copolymer of vinylpyrrolidone/dimethylaminoethylmethacrylate and complex stereoselectivity of hydroxyethyl cellulose/hyaluronic acid the OIC acid;

(c) from about 0.1% wt. to about 1% of the mass. preservative and

(d) from about 40% wt. to about 80% of the mass. water.

Other aspects and objectives of the present invention will become more apparent from the following description, examples and claims.

DEFINITION

Yet other specifications, the term "percentage" or "%"used in the present description in connection with the amount or concentration of an ingredient or component in a composition refers to the percentage relative to the total weight of the final composition.

Used in the present description, the term "essentially parallel" refers to the maximum deviation of ±30° from the horizontal direction.

Used in the present description, the term "tension" refers to deformation of the skin in percent caused by applying the polymeric composition of the present invention to the skin and subsequent drying, as measured by a modified method of Correlation digital speckled image (DISC), as described in application for U.S. patent No. 2009/0022665A1, the contents of which are fully incorporated in the present description for all purposes.

BRIEF DESCRIPTION of DRAWINGS

In Fig. 1 is a diagram, which uses column compares the number of type I collagen produced by every cell in three different types fibroblastic glue is OK dermis, obtained from individuals of different ages (respectively, newborn, at the age of 24 and 45 years) with and without the application of a static linear tension after 24 hours of growth in vitro.

In Fig. 2 is a diagram, which uses column compares the number of fibronectin produced for each cell, three different types fibroblastic cells of the dermis obtained from individuals of different ages (respectively, newborn, at the age of 24 and 45 years) with and without the application of a static linear tension after 24 hours of growth in vitro.

In Fig. 3 is a diagram, which uses column compares the number of laminin produced for each cell, four different types fibroblastic cells of the dermis obtained from individuals of different ages (respectively, newborn, at the age of 24 years, 45 years and 68 years) with and without the application of a static linear tension after 24 hours of growth in vitro.

In Fig. 4A and 4B is a schematic illustrating the polymer composition of the present invention is applied to a wrinkle in the skin to create mechanical stresses on the skin surface for biomechanical stimulation of collagen synthesis in skin cells and reduce the appearance of wrinkles of the skin.

In Fig. 5 is redstavlena schematic diagram, showing how the polymer composition of the present invention can be applied to the facial region of the user for biomechanical processing typical facial lines and wrinkles.

In Fig. 6A and 6B shows a side view and a top illustrative cosmetic device of the present invention for applying a polymer composition onto the skin for the formation of elongated polymeric strips.

In Fig. 7 shows a side view illustrative of the cosmetic device according to the present application with the first and second heads of the applicator for applying the polymer composition according to the present application and additional cosmetic compositions to the skin.

DETAILED DESCRIPTION of the INVENTION AND ITS PREFERRED embodiments

To assess the impact of deformation caused by the application of external mechanical force or stress on the levels of expression of the protein of skin cells growing in vitro, the applicants used the system FlexCell® FX-5000™, manufactured by FlexCell International Corp at Hillsborough, NC. System FlexCell® FX-5000TMis a computer-controlled bioreactor that uses vacuum pressure to the application of cyclic or static voltage on the cells cultivated on cultural tablets with flexible bottom. A certain, adjustable static or cyclic strain can be to EDI, growing in vitro, and the degree of deformation is governed by the applied force of the vacuum, which can provide an elongation of the substrate up to 25%.

Three different types fibroblastic cells of the dermis, which included neonatal dermal fibroblast cells, dermal fibroblast cells derived from 24-year-old individual, and dermal fibroblast cells obtained from a 45-year-old individual was tested to identify the impact of the supplied external voltage on the levels of protein expression in cells obtained from individuals of different ages. All three types of dermal fibroblastic cells were placed in tablets for cell culture system FlexCell® FX-5000TM. Different types of dermal fibroblasts grown and subcultured modified in Dulbecco environment Needle (catalog number 11965, Invitrogen, Carlsbad, CA) supplemented with 10% fetal calf serum (catalog number SH30071.03, Hyclone, Logan UT) and 1% penicillin (5000 IU/ml)/Streptomycin (5000 μg/ml) (catalog number 30-001-CI, Mediatech, Manassas, VA). Cells are grown at 37°C in 100% humidified atmosphere containing 5% CO2. The vacuum force applied to each culture plate to obtain a static line voltage to provide elongation of the substrate by about 10% within about 24 hours. In the following, the number of type I collagen and fibronectin produced n the each cell, measured for each type of dermal fibroblasts and then compared with the number produced by the control cells (i.e., the same type of dermal fibroblasts grown for 24 hours, but without voltage). The measurement results illustrated in Fig. 1 and 2, which indicate that the filing of a linear static stress had little or no effect on the levels of expression of type I collagen and fibronectin in the neonatal dermal fibroblastic cells, but it significantly increased the levels of expression of type I collagen and fibronectin in the dermal fibroblasts obtained from 24-year-old and 45-year-old individuals.

Tests similar to those described above in this application was performed to measure the static line voltage on the expression of laminin in the dermal fibroblasts. In particular, four different types of dermal fibroblastic cells, which included neonatal dermal fibroblast cells and dermal fibroblast cells derived from 24-year-old individual, 45-year-old individual and 68-year-old individual was placed in cell culture the tablet system FlexCell® FX-5000TM. The vacuum force applied to each culture plate to obtain a static line voltage to provide elongation of the substrate by about 10% for example is but 24 hours. In the following, for each type of dermal fibroblasts was measured by the number of laminin produced in every cell, and then compared with the amount of laminin produced by the control cells (i.e., dermal fibroblasts of the same type, grown for 24 hours, but without affecting the voltage). The measurement results illustrated in Fig. 3, indicate that the application of the static line voltage provided or little effect or even a negative effect on the expression level of laminin in younger cells (i.e., in the neonatal and obtained from 24-of letnich individuals dermal fibroblastic cells), but it significantly increased the expression level of laminin in older cells (i.e., dermal fibroblasts, obtained from a 45-year-olds and 68-year-old individuals).

Collagen, fibronectin and laminin are important proteins responsible for maintaining the structural integrity and cellular function of skin cells and improve elasticity and density of skin. On the basis described above in this application of the experimental results, the applicants believe that the application of an external stress or tension to the skin surface can effectively stimulate the synthesis of these important proteins in the skin cells, which in turn will improve the elasticity and firmness of the skin, reduce the appearance of fine lines and Armin on the skin and give the user a more youthful appearance.

This external voltage or tension exerted through the skin surface, is achieved in this invention by application to the skin polymeric composition which is able to shrink after drying. In particular, the polymer composition of the present invention includes the first polymer and the second polymer, or dissolved or dispersed in a solvent system containing one or more solvents. The first polymer is an anionic polymer, is able to decrease after evaporation of one or more solvents, while the second polymer is a cationic polymer capable of forming a polymer complex with the first polymer, and simultaneously contact the surface of the skin. The first and second polymers in combination form a polymeric network, which is well associated with the surface of the skin, and is also able to decrease after evaporation of the solvent for tensioning or stretching of the skin.

The system described above solvent may include any solvent or solvents suitable for use in cosmetic products and products for skin care. Suitable solvents that can be used in the polymeric compositions of the present invention, include, without limitation: water, C1-C4 alcohols, such as ethanol, propanol, isoprop the Nol, the polyols and the PoE-oil, such as carbitol, 2-butoxyethanol, polypropylenglycol, simple onomatology ether of propylene glycol, simple onomatology ether of diethylene glycol, simple onomatology ether, butyleneglycol, hexyleneglycol, glycerol, ethoxyphenol, etokxidiglicol; propylene carbonate, and mixtures thereof. In a preferred, but not required embodiment of the present invention, the solvent system contains water and optionally one or more miscible with water solvents. In a more preferred embodiment, the solvent system consists essentially of water.

The amount of solvent (solvent)contained in the polymer composition of the present invention, may be in the range of from about 1% to about 99% relative to the total weight of the composition, preferably from about 10% to about 90 wt. -%, and preferably, from about 40% to about 80% of the mass.

As described above, the first polymer is preferably soluble in water or dispersible in water anionic polymer, such as, for example, polystyrenesulfonate sodium, which is commercially available from Akzo Nobel Surface Chemistry LLC (Chicago, IL) under the brand name Flexan® II; a copolymer of styrene/acrylate/methacrylate ammonium, which is commercially available from Interpolymer Corporation (Louisville, KY) trading under the brand name Syntran® PC5100NP; a copolymer of caprolactam/vinylpyrrolidone/dimethylaminoethylmethacrylate, which is commercially available from International Specialty Products (Wayne, NJ) under the trademarks Advantage® S and Gaffix® VC-713; a copolymer of vinylpyrrolidone/dimethylaminoethylmethacrylate, which is commercially available from International Specialty Products (Wayne, NJ) under the trade name Styleze® CC-10; a copolymer of vinylpyrrolidone/dimethylaminoethylmethacrylate, which is commercially available from International Specialty Products (Wayne, NJ) as copolymer 958, and a copolymer of dimethylacrylamide/acrylic acid/polystyrene ethyl methacrylate, commercially available from the company Polytherapeutics, Inc. (New Brunswick, NJ) under the trademark PharmaDur®.

The amount of the first polymer contained in the polymer composition of the present invention, may be in the range of from about 1% to about 60% relative to the total weight of the composition, preferably from about 10% to about 50 wt. -%, and preferably, from about 20% to about 40% of the mass.

As described above, the second polymer is preferably soluble in water or dispersible in water anionic polymer, such as, for example, a copolymer of polyfactorial with butylmethacrylate, which is also referred to as "polyquaternium-51" and commercially available from NOF Corporation (Tokyo, Japan) under the trade names Lipidure®-PMB and Lipidure®-Ph 10; the copolymer of winhelper the lidón/dimethylaminoethylmethacrylate/ methylenedioxymethamphetamine, which is also referred to as "polyquaternium-55" and commercially available from International Specialty Products (Wayne, NJ) under the trade name Styleze® W-20; a copolymer of vinylpyrrolidone/metallicametallicametall, which is also referred to as "polyquaternium-28" and commercially available from International Specialty Products (Wayne, NJ) under the trade name Gafquat® HS-100; a copolymer of vinylpyrrolidone/dimethylaminoethylmethacrylate, which is also referred to as "polyquaternium-11" and commercially available from International Specialty Products (Wayne, NJ) under the trademark Gafquat® 755N; and associational complex and stereoselectivity of hydroxyethyl cellulose (also referred to as the "polyquaternium-24") and hyaluronic acid with high molecular weight, which is commercially available from Amerchol Corporation (Bound Brook, NJ) under the trade name BIOCARE Polymer HA-24.

The amount of the second polymer contained in the polymer composition of the present invention, may be in the range of from about 0.1% to about 50% relative to the total weight of the composition, preferably from about 1% to about 20 wt. -%, and preferably, from about 2% to about 15% of the mass.

The polymer composition of the present invention may also contain a preservative, preferably, water-soluble preservatives such as Phenoxyethanol, potassium sorbate, imidazolidinethione, p-hydroxybenzoate, clonality p-hydroxybenzoic acid, designed for CTFA (Association of cosmetic, hygienic and aromatic funds), parabens, Ethylhexylglycerin, carisolrodol/Phenoxyethanol/hexyleneglycol etc. Other preservatives suitable for use in the polymer compositions of the present invention, described in the International Cosmetic Ingredient Dictionary and Handbook, twelfth edition, 2004 (International dictionary and guide for cosmetic ingredients, 12th edition), the complete disclosure of which is incorporated into the present application by reference.

The amount of preservative contained in the polymer composition of the present invention, may be in the range of from about 0,001% to about 10% relative to the total weight of the composition, preferably from about 0.01% to about 5 wt. -%, and preferably, from about 0.1% to about 1% of the mass.

In a preferred, but not necessary, embodiment of the present invention, the above-described polymer composition comprises from about 20 wt%. up to about 40% of the mass. the first polymer, from about 1 wt%. up to about 20% of the mass. the second polymer, from about 0.1 wt%. to about 1% of the mass. preservative and from about 40 wt%. to about 80% of the mass. water. Preferably, the first polymer is polystyrenesulfonate sodium; the second polymer is a copolymer of polyfactorial with butylmethacrylate and design is rvant represents Phenoxyethanol.

In an even more preferred embodiment of the present invention the polymer composition contains from about 25% of the mass. up to about 30% of the mass. polystyrenesulfonate sodium, from about 8% of the mass. to about 12% of the mass. copolymer polyfactorial with butylmethacrylate, from about 0.3% of the mass. to about 0.8% of the mass. of Phenoxyethanol and from about 55% wt. up to about 70% of the mass. water. Most preferably, the polymer composition of the present invention consists essentially of the above ingredients.

The polymer composition of the present invention may optionally contain one or more active ingredients for skin care products or active substances for skin care, well-known in this field. Used in the present description, the term "active ingredients for skin care products or active substances for skin care" refers to agents that provide a beneficial effect on the skin, not just improve the physical characteristics of the composition for local application. For example, the polymer composition may contain anti-aging, which can protect the skin against photo - aging by acceptional free radicals, prevention of lipid peroxidation, inactivation of lipoxygenase, inhibition of undesirable enzymatic activity the opportunities and the stimulation of collagen synthesis. The polymer composition may also include anti-acne preparations inhibiting enzymes, tools, stimulating collagen, sunscreens, antioxidants, exfoliants, means for removing age spots, keratoses and wrinkles, analgesics, anesthetics, antibacterial agents, protivogryazevye tools, antifungal agents, antiviral agents, anti-dandruff, anti-dermatitis, anti-itching, anti-emetics, anti-inflammatories, anti-hyperkeratosis, antiperspirants, antipsoriatic drugs, anti-seborrhea, anti-wrinkle, antihistamines, medicines for skin lightening, depigmentosus remedies, vitamins corticosteroids, fake tan, hormones, retinoids, such as retinoic acid and retinol, topical cardiovascular tools, clotrimazole, ketoconazole, miconazole, griseofulvin, hydroxyzine, diphenhydramine, pramoxine, lidocaine, procaine, mepivacaine, monobenzone, erythromycin, tetracycline, clindamycin, meclocycline, hydroquinone, minocycline, naproxen, ibuprofen, theophylline, kromolin, albuterol, topical steroids, such as hydrocortisone, hydrocortisone 21-acetate, hydrocortisone 17-valerate and hydrocortisone 17-butyrate, betamethasone shaft is at, betamethasone dipropionate, benzoyl peroxide, crotamiton, propranolol, promethazine, vitamin a palmitate, vitamin E acetate, and mixtures thereof.

The above-described active ingredients for skin care are only optional components of the polymer compositions of the present invention and may not be included in such a composition without a material impact on the desired function of polymer composition.

Polymer composition according to the present application may further comprise a substance, usually used in compositions for topical application or used for skin care compositions which include without limitation, wetting agents, binding agents, chelating agents, surfactants, softeners, stabilizers, thickeners, moisturizers, pigments, etc. Such substances should be present only in amounts that do not affect the ability of the polymeric composition to contact the skin surface and to decrease after evaporation of the solvent.

For example, softeners that can be used in the polymeric compositions of the present invention, include, without limitation: stearyl alcohol, cetyl alcohol, alerby alcohol, societally alcohol, fatty alcohols, propane-1,2-diol, butane-1,3-diol, octadecane-2-ol, glycerylmonostearate, isoprop isostearate, stearic acid, isostearoyl acid, isolatedstore, isopropylene, butilstearat, isopropylene, exellent, decillia, isobutylacetate, cetylpalmitate, isopropyl, palmitic acid, dimethylpolysiloxane, glycerylmonostearate, di-n-BUTYLCARBAMATE, isopropylmyristate, Boutilimit, myristoleate, isopropylindole, laurinlactam, myristylated, polyethylene glycol, triethylene glycol, lanolin, acetylated lanolin, sesame oil, coconut oil, peanut oil, castor oil, mink oil, mineral oil and petrolatum. Softening substance, in case of its presence in the compositions of the present invention, preferably, is present in a total amount from about 1% to about 20%, and preferably from about 5% to about 15% relative to the total weight of the composition.

Additionally, any suitable thickener commonly used in cosmetic and used for personal care products, can be added to polymer compositions of the present invention to increase the viscosity of the compositions. Preferably, the thickening agent includes, without limitation: starch, resin (such as Arabian gum), clays (such as kaolin), hydrogenated aluminum silicate, magnesium silicate-aluminum, white carbon, polyacrylic acid, hydroxyethyl cellulose, CT is oxygenology polymer, sodium carboxymethylcellulose or other derivatives of cellulose, the glycol monostearate and sodium alginates. Thickener, in case of its presence in the compositions of the present invention, preferably, is present in a total amount from about 1% to about 20%, and preferably, from about 5% to about 15% relative to the total weight of the composition.

Humidifiers that can be used include, without limitation: polyhydric alcohols, including glycerol, polyalkyleneglycol and alkylenedioxy and mixtures thereof, hyaluronic acid, urea, glycerol, sorbitol, 2-pyrrolidone-5-carboxylate sodium, soluble collagen, dibutyl phthalate and gelatin. Humidifier, if present in the compositions of the present invention, preferably, is present in a total amount from about 1% to about 20%, and preferably, from about 5% to about 15% relative to the total weight of the composition.

The polymer composition of the present invention may also contain additional cosmetic ingredients that complement the aesthetic and functional characteristics of the compositions of the present invention. For example, pigments, powders and flavourings can be used to increase the aesthetic appeal of the composition of the present invention. The pigments can be selected from the bottle : the Ki acceptable inorganic and organic pigments, such as pigments described in the 12th edition of the International dictionary and guide for cosmetic ingredients 2004 Suitable inorganic pigments may include iron oxides, titanium dioxide, zinc oxide, silicates of metals (such as mica, talc, kaolin, etc.), bismuth oxychloride and the like. Suitable organic pigments may include aluminum colorful lacquer, zirconium colorful lacquer, calcium colorful lacquer, dyes, D&C and FD&C and colorful nail polishes. Powders that can be added to the composition for topical application according to the present invention, include chalk, talc, fallerovo earth, colloidal silicon dioxide, sodium polyacrylate, tetraalkyl and/or the smectites of trialkylamine and chemically modified silicate of magnesium-aluminum. Composition for topical application according to the present invention may optionally contain a flavouring agent in a quantity sufficient to make the composition more attractive for the consumer. The pigment(s), powder or flavoring, if present in the compositions of the present invention, preferably, is present in a total amount from about 1% to about 20%, and preferably, from about 5% to about 15% relative to the total weight of the composition.

Fig. 4A and 4B illustrate how such a polymer composition can use is taken to create the desired stress or tension on the skin surface. As shown in Fig. 4A, the polymer composition according to the present application is applied to the first and second areas on the skin for the formation of the first and second elongated polymeric strips 12 and 14. Preferably, but not necessarily, each of the bands 12 and 14 is characterized by a width in the range from approximately 2 mm to approximately 2 refer to First and second elongated polymer strip 12 and 14 are separated from each other by a specified distance (D)between them at least one fine line or wrinkle 10. Preferably, but not necessarily, extra long polymer lines 12 and 14 extend in the direction which is essentially parallel fine lines or wrinkles 10. In Fig. 4B shows that after subsequent drying and evaporation of the solvent (solvent) of the polymer composition, elongated polymer strip 12 and 14 are reduced with increasing distance (d) between them by pulling or stretching the skin for biomechanical stimulation of collagen synthesis in skin cells reducing the appearance of fine lines or wrinkles 10. Preferably, but not necessarily, the stretching of the skin is from about 5% to 20%, according to the modified measurement technique Correlation digital speckled image (DISC), as described in application for U.S. patent No. 2009/0022665A1, the contents of which are fully incorporated in the present description for all goals is to it.

Fig. 5 illustrates how the polymer composition of the present invention can be applied to different areas of the face of a potential user. For example, the polymer composition may be applied along the lines 20 on the forehead of the user for the formation of elongated polymeric strips 22 and 24, each of which is located on one side of the lines 20 and runs essentially parallel to the wrinkle 20. The polymer composition may also be applied along wrinkles 30 in the corner of the user's eyes to the formation of two elongated polymeric strips 32 and 34, each of which is located on one side of wrinkles 30 and runs essentially parallel to the wrinkle 30. The polymer composition may further be applied along lines 40 around the mouth of the user for the formation of two elongated polymeric strips 42 and 44, each of which is located on one side of the lines 40 and runs essentially parallel to the wrinkle 40.

Certain ways of applying the present invention will depend on the final intended use of the above-described polymeric composition. For example, the polymer composition may be applied to the skin based on the need to achieve results immediate wrinkle reduction (usually observed in the range of five to ten minutes). Alternatively, it can be applied to the skin again in line the AI with a pre-established schedule, to achieve the effect of long-term stimulation of collagen synthesis and the effect of reduction of wrinkles. The polymer composition of the present invention can be applied directly to clean skin, without applying any moisturizer, Foundation, cosmetics, etc. Alternative, the polymer composition of the present invention can be applied over moisturizer or under him, and, optionally, over or under Foundation and/or cosmetics. The amount of polymeric composition, the subject application every time, the area of application, duration of application and frequency of application can vary widely, depending on the specific needs of the user. For example, the polymer composition can be applied during at least one month and with a frequency in the range from about once per week to about five times a day. As another example, the polymer composition is applied over a period of about six months and with a frequency in the range from about three times a week to about three times per day, and preferably, about once or twice a day.

Polymer strips described above can be easily formed using a cosmetic device comprising a housing having a compartment filled with the above-described polymer composition, and the head of the applicator, the location is nnow at one end of the housing, and built through the liquid with a fluid-filled compartment. Applicator head may have any profile or shape and may be made of any material suitable for feeding a polymer composition to the skin surface for the formation of an elongated strip having a width in the range from about 2 mm to about 2 cm

For example, in Fig. 6A and 6B shows the side and top views of illustrative cosmetic device 50 that includes an elongated housing 51, which has a compartment 52, the filled polymer composition of the present invention. Cosmetic device 50 also includes the head of the applicator 54, which is located at one end of the elongated housing 51 and through the fluid communicates with the fluid-filled compartment 52. At the tip of the applicator head 54 has an elongated hole 54a through which the polymer composition can be supplied from the first compartment 52 for the formation of elongated polymer strips (not shown) on the surface of the skin. Width educated in this way the elongated polymer strips is determined by the length of the openings 54a, which preferably is in the range from about 2 mm to about 2 cm When not in use, the head of the applicator 54 preferably is closed by a cap 55 in order to prevent contamination or leakage.

In an alternative embodiment, n is a free-standing applications cosmetic composition comprising at least one active ingredient, a biologically capable of stimulating the synthesis of collagen in the skin cells, in addition, is provided in addition to the above-described polymer composition, and such cosmetic composition is applied directly on fine lines and wrinkles on the skin to reduce their appearance. Suitable active ingredients that can be used for the formation of such cosmetic compositions include, without limitation: vitamins A, C, and E and their analogues and derivatives (such as retinoic acid, retinal, retinol, reinjected or retinilpalmitat, ascorbic acid, ascorbyl palmitate, magnesium ascorbyl phosphate, sodium ascorbyl phosphate, ascorbyl alpha - and beta-glucoside, Tocopheryl and Tocopheryl acetate), aminoacylase connection glucan (such as alpha-glucan and beta-glucans), specific growth factors such as transforming growth factor or TGF beta), ginsenoside, certain hydrolyzed proteins (e.g., hydrolyzed milk or whey protein). The active ingredients that are often used to stimulate the synthesis of collagen, also include peptides and their derivatives, such as, for example, carnitine, carnosine, creatine, peptides matrikin (e.g., lysyl-threonyl-threonyl-lysyl-serine), peptide structure, t is the cue as palmitoylation Pentapeptide (for example, Matrixyl manufactured by the company Sederma) and Oligopeptide with the trade name winkipedia (manufactured by the company Vincience, France). In addition, as stimulators of collagen synthesis are used such compounds as asianova acid, madecassoside acid, madecassoside, asiaticoside, plant extracts, such as extracts from species of aloe, umbrella, Czestochowa, soy extract and soy isoflavones, extracts of Ginkgo biloba extract, Niacinamide, astaxanthin, genistein, daidzein, rutin, chrysin, Morin, alkaloids betel nuts, Forskolin, betulin acid, glutamine, glycolic acid, fragments of collagen, flavonoids, tannins and saponins, such as obtained from the bark of Mimosa, kudzu root or root of Scutellaria (skullcap), resveratrol and derivatives thereof, and water-soluble aluminum salts such as aluminum chloride), calcium, magnesium and iron.

The above-described cosmetic composition can be used in combination with a polymer composition of the present invention to achieve and biological, and biomechanical stimulation of collagen synthesis. In Fig. 7 shows a side view illustrative of the cosmetic device 100, which can be used for filing a joint polymeric compositions and cosmetic compositions for the treatment of wrinkles by double exposure. In particular, a cosmetic device 100 contains UD is inanny housing 110, with two compartments for liquid 112 and 116. The first compartment for liquid 112 is filled polymer composition of the present invention, as described above, while the second compartment for fluid 116 filled with the above-described cosmetic composition. The first applicator head 114 is located at one end of the housing 110 and is conveyed through the liquid from the first compartment 112. The first applicator head 114 may be formed of a porous material such as felt or nylon fiber, for feeding a polymer composition to the skin surface for the formation of the elongated polymer strip having a width in the range from approximately 2 mm to approximately 2 see the Second applicator head 118 is located at the other, opposite end of the housing 110 and is conveyed through the liquid from the second compartment 116. The second applicator head 118 can be formed in the form of a pen tip for the filing of cosmetic compositions directly on a fine line or wrinkle in the form of lines having a width in the range from about 0.1 mm to about 2 mm When not in use, the applicator head 114 and 118, preferably, respectively, covered by a cap 115 and 119 in order to prevent contamination or leakage.

Although the invention has been variously described with reference to illustrative embodiments of and signs, it should be understood that the above-described variants of the wasp is estline and signs are not intended to limit the scope of the invention, and that other variations, modifications and other embodiments of will be apparent to the average of the experts in this field. Therefore, the invention should be considered in a broad aspect, in accordance with the following claims.

1. The way biomechanical stimulation of collagen synthesis in skin cells and reduce the appearance of fine lines and wrinkles on the skin, including:
(a) forming a polymeric composition comprising a first polymer and a second polymer, which is dissolved or dispersed in a solvent system containing water, where the first polymer is a water-soluble or dispersible in water anionic polymer, is able to decrease after evaporation of the solvent, and is selected from the group consisting of polystyrenesulfonate sodium styrene/acrylate/methacrylate ammonium copolymer of vinylcaprolactam/vinylpyrrolidone/dimethylaminoethylmethacrylate, copolymer of vinylpyrrolidone/dimethylaminoethylmethacrylate, copolymer of vinylpyrrolidone/dimethylaminoethylmethacrylate and copolymer dimethylacrylamide/acrylic acid/politicalintelligence, and where specified the second polymer is a water-soluble or dispersible in water, a cationic polymer, capable of forming a polymer complex with the first polymer, and odnovremennoubezhdaet with the surface of the skin, and selected from the group consisting of a copolymer of polyfactorial with butylmethacrylate, copolymer of vinylpyrrolidone/dimethylaminoethylmethacrylate/methylenedioxymethamphetamine copolymer of vinylpyrrolidone/metallicametallicametall, copolymer of vinylpyrrolidone/dimethylaminoethylmethacrylate and complex stereoselectivity of hydroxyethyl cellulose/hyaluronic acid;
(b) applying a polymer composition onto the first area and the second area on the skin where the first and the second region are separated from each other by a specified distance, at least one fine line or wrinkle between them; and
(c) drying the applied resin composition in the first and second areas on the skin to evaporate the water in the solvent system, and was initiated by the reduction of the polymer compositions in the first and second areas,
where the specified reduction creates a mechanical tension on the skin surface between the first and second regions, which has been running for biomechanical stimulation of collagen synthesis in skin cells and reduce the appearance of fine lines or wrinkles on the skin.

2. The method according to claim 1, where the polymer composition contains:
(a) from about 20% wt. up to about 40% of the mass. polystyrenesulfonate sodium;
(b) from about 1% wt. up to about 20% of the mass. copolymer polyfactorial and butylmethyl the same;
(C) further comprises from about 0.1 wt%. to about 1% of the mass. preservative; and
(d) from about 40% wt. to about 80% of the mass. water.

3. The method according to claim 1, where the polymer composition is applied to the first and second areas on the skin for the formation of elongated polymer lines located in the direction that is essentially parallel to the at least one fine line or wrinkle.

4. The method according to claim 3, where each of the elongated polymeric strips has a width in the range from about 2 mm to about 2 cm

5. The method according to claim 3, where each of the elongated polymer strips is reduced after evaporation of the solvent system containing water to create a tension in the range from about 5% to about 20%.

6. The method according to claim 1, further comprising applying at least one fine line or wrinkle cosmetic composition containing at least one active ingredient, a biologically capable of stimulating the synthesis of collagen in the skin cells and reduce the appearance of fine lines and wrinkles on the skin.

7. The method according to claim 6, where the specified at least one active ingredient selected from the group consisting of vitamins a, C and E, and their analogues and derivatives, aminoethylamide connection, glucans, growth factors, ginsenoside, hydrolyzed protein, peptide substances or their structures and derivatives, fragments of call is s, asiatoday acid, madecassol acid, madecassoside, asiaticoside, Botanical extracts of aloe, umbrella, Czestochowa, soy extract and soy isoflavones, extracts of Ginkgo biloba, Niacinamide, astaxanthin, genistein, daidzein, rutin, hrisin, Morin, alkaloids betel nuts, Forskolin, Betulinol acid, glutamine, glycolic acid, flavonoids, tannins, saponins, resveratrol and its derivatives, water soluble salts of aluminum, calcium, magnesium and iron, and mixtures thereof.

8. The method according to claim 6, where this cosmetic composition is applied directly on a fine line or wrinkle in the form of a strip having a width in the range from about 0.1 mm to about 2 mm

9. Cosmetic device for applying a polymer composition onto the skin, including:
a housing including a first compartment, a filled polymer composition comprising a first polymer and a second polymer, which is dissolved or dispersed in a solvent system containing water, where the first polymer is a water-soluble or dispersible in water anionic polymer, is able to decrease after evaporation of the solvent, and is selected from the group consisting of polystyrenesulfonate sodium styrene/acrylate/methacrylate ammonium copolymer of vinylcaprolactam/vinylpyrrolidone/dimethylaminoethyl the acrylate, copolymer of vinylpyrrolidone/dimethylaminoethylmethacrylate, copolymer of vinylpyrrolidone/dimethylaminoethylmethacrylate and copolymer dimethylacrylamide/acrylic acid/politicalintelligence, and where the second polymer is a water-soluble or dispersible in water, a cationic polymer, capable of forming a polymer complex with the first polymer, and simultaneously contact the surface of the skin, and is selected from the group consisting of a copolymer of polyfactorial with butylmethacrylate, copolymer of vinylpyrrolidone/dimethylaminoethylmethacrylate/methylenedioxymethamphetamine, copolymer of vinylpyrrolidone /metallicametallicametall, copolymer of vinylpyrrolidone/dimethylaminoethylmethacrylate and complex stereoselectivity of hydroxyethyl cellulose/hyaluronic acid; and
head first applicator located at the end of the housing, and through the fluid chamber connected with the first compartment, where the head of the first applicator is designed for feeding a polymer composition to the skin surface for the formation of an elongated strip having a width in the range from about 2 mm to about 2 cm

10. Cosmetic device according to claim 9, where the polymer composition contains:
(a) from about 20% wt. up to about 40% of the mass. polystyrenesulfonate sodium;
(b) when is Erno 1% of the mass. up to about 20% of the mass. copolymer polyfactorial and butyl methacrylate;
(c) further comprises from about 0.1 wt%. to about 1% of the mass. preservative and
(d) from about 40% wt. to about 80% of the mass. water.

11. Cosmetic device according to claim 9, where the polymer composition contains:
(a) from about 25% of the mass. up to about 30% of the mass. polystyrenesulfonate sodium;
(b) from about 8% of the mass. to about 12% of the mass. copolymer polyfactorial and butyl methacrylate;
(c) further comprises from about 0.3% of the mass. to about 0.8% of the mass. preservative and
(d) from about 55% wt. up to about 70% of the mass. water.

12. Cosmetic device according to claim 9, where the specified enclosure further includes a second compartment filled with a cosmetic composition containing at least one active ingredient, a biologically capable of stimulating the synthesis of collagen in the skin cells and reduce the appearance of fine lines and wrinkles on the skin, and where said device further includes a second applicator head located at the other, opposite end of the housing and is communicated through the fluid with the specified second compartment where the specified second applicator head is designed to supply cosmetic compositions to the skin surface in the form of a strip having a width in the range from about 0.1 mm to about 2 mm

3. Cosmetic device according to item 12, where the at least one active ingredient selected from the group consisting of vitamins a, C and E, and their analogues and derivatives, aminoethylamide connection, glucans, growth factors, ginsenoside, hydrolyzed protein, peptide substances or their structures and derivatives, fragments of collagen, asiatoday acid, madecassol acid, madecassoside, asiaticoside, Botanical extracts of aloe, umbrella, Czestochowa, soy extract and soy isoflavones, extracts of Ginkgo biloba, Niacinamide, astaxanthin, genistein, daidzein, rutin, hrisin, Morin, alkaloids nuts betel, Forskolin, Betulinol acid, glutamine, glycolic acid, flavonoids, tannins, saponins, resveratrol and its derivatives, water soluble salts of aluminum, calcium, magnesium and iron, and mixtures thereof.

14. Composition for topical application, for biomechanical stimulation of collagen synthesis in skin cells and reduce the appearance of fine lines or wrinkles on the skin, containing:
(a) from about 20% wt. up to about 40% of the mass. the first polymer selected from the group consisting of polystyrenesulfonate sodium styrene/acrylate/methacrylate ammonium copolymer of vinylcaprolactam/vinylpyrrolidone/dimethylaminoethylmethacrylate, copolymer of vinylpyrrolidone/dimethylaminoethylmethacrylate, with the polymer of vinylpyrrolidone/dimethylaminoethylmethacrylate and copolymer dimethylacrylamide/acrylic acid/politicalintelligence;
(b) from about 1% wt. up to about 20% of the mass. a second polymer selected from the group consisting of a copolymer of polyfactorial with butylmethacrylate, copolymer of vinylpyrrolidone/dimethylaminoethylmethacrylate/methylenedioxymethamphetamine, copolymer of vinylpyrrolidone /metallicametallicametall, copolymer of vinylpyrrolidone/dimethylaminoethylmethacrylate and complex stereoselectivity of hydroxyethyl cellulose/hyaluronic acid;
(c) from about 0.1% wt. to about 1% of the mass. preservative and
(d) from about 40% wt. to about 80% of the mass. water.

15. Composition for topical application according to 14, where the first polymer is polystyrenesulfonate sodium, where the second polymer is a copolymer of polyfactorial with butylmethacrylate, and where preservatives are Phenoxyethanol.

16. Composition for topical application according to § 15, consisting essentially of polystyrenesulfonate sodium copolymer polyfactorial with butylmethacrylate, Phenoxyethanol and water.



 

Same patents:

FIELD: medicine.

SUBSTANCE: as active ingredients, the presented toothpaste contains troxerutin in the amount of 0.1-0.3 wt %, ectoin in the amount of 0.01-0.1 wt % and nicotinamide in the amount of 0.05-0.1 wt %, as well as a biologically active additive containing aloe vera and herbal infusion; an anti-caries additive and target additives in the amounts to make the above functions be fulfilled; a cosmetically acceptable base containing an abrasive, a humectant, a thickening agent, a cleansing and foaming agent, a sweetening agent, and water as a medium.

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14 cl, 5 tbl, 2 ex

FIELD: medicine.

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EFFECT: improved properties of the composition.

17 cl, 11 ex

FIELD: medicine.

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EFFECT: invention provides user's pleasant sensations, improves the skin and hair with using no hard surfactants.

20 cl, 7 ex, 8 tbl

FIELD: medicine.

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3 ex, 2 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutics and cosmetology and concerns a heparanase activity inhibitor containing a cyclic carboxamide derivative being an active ingredient and presented by formula (I) or a salt thereof to be used as an anti-wrinkle or skin lightening agent.

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6 cl, 13 dwg, 2 tbl, 6 ex

FIELD: medicine, pharmaceutics.

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9 cl, 13 ex, 4 tbl

Anti-wrinkle agents // 2503443

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to chemical-pharmaceutical industry and represents wrinkle-reducing agents containing compounds presented by general formula (1), stereoisomers or pharmacologically acceptable salts thereof, wherein R1 represents a hydrogen atom or a linear or branched alkyl group with 1-8 carbon atoms; R2 represents -SH, -SO3H, -S-X2, -SO-X3, -S02-X4, X2-X4 represents carbon atoms or aliphatic hydrocarbon groups with 1-8 carbon atoms independently, R3 represents a hydrogen atom or an acyl group with a linear or branched alkyl chain with 1-8 carbon atoms, R4 represents a phenyl, tolyl, ethyl phenyl, propyl phenyl, butyl phenyl, pentyl phenyl, hexyl phenyl, methoxyphenyl, ethoxyphenyl, propyl oxyphenyl, butyl oxyphenyl, pentyl oxyphenyl, hexyl oxyphenyl or biphenyl group, m is equal to 0, n is equal to the integer 1 or 2.

EFFECT: invention provides preparing the compounds and cosmetic products possessing the anti-wrinkle effectiveness.

10 cl, 11 ex, 2 tbl, 7 dwg

FIELD: medicine.

SUBSTANCE: invention refers to methods of treating early enamel loss. The presented method of treating or reducing early enamel caries involves the dental application of an effective amount of a dental composition wherein the dental composition has a main formulation containing dicalcium phosphate, wherein the dental composition additionally contains arginine in the free or salt form, and an effective amount of fluoride, wherein arginine is found in the amount of 2 to 10 wt % of total weight of the dental composition.

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3 cl, 1 tbl, 4 ex

FIELD: chemistry.

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1 ex

FIELD: medicine.

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6 cl, 3 ex, 4 tbl

FIELD: medicine.

SUBSTANCE: as active ingredients, the presented toothpaste contains troxerutin in the amount of 0.1-0.3 wt %, ectoin in the amount of 0.01-0.1 wt % and nicotinamide in the amount of 0.05-0.1 wt %, as well as a biologically active additive containing aloe vera and herbal infusion; an anti-caries additive and target additives in the amounts to make the above functions be fulfilled; a cosmetically acceptable base containing an abrasive, a humectant, a thickening agent, a cleansing and foaming agent, a sweetening agent, and water as a medium.

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14 cl, 5 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: combined dental whitening and oral therapeutic composition for delaying and inhibiting dental caries, delaying or inhibiting demineralisation and promoting dental remineralisation. The composition contains an effective amount of a whitening agent and arginine in a salt form in the amount of 0.1 wt % to 50 wt % with the whitening agent and arginine dispersed in a matrix material.

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17 cl, 11 ex

FIELD: medicine.

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EFFECT: invention provides user's pleasant sensations, improves the skin and hair with using no hard surfactants.

20 cl, 7 ex, 8 tbl

FIELD: food industry.

SUBSTANCE: method involves preliminary milling of berries into particles sized 2-5 mm; then berries surface treatment with enzyme preparations. Before ultrasound exposure one performs the components soaking in well or purified water during 6-8 hours at a temperature of 35-40°C, after treatment one proceeds with the extract cooling and filtration.

EFFECT: method allows to produce an extract with enhanced biological activity, nutritive value and bactericidal effect and to increase the extractive, flavouring and colouring substances yield.

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely physiotherapy. A method involves the administration of chophytol, diet therapy, magnetic therapy and exposure to electric current. The magnetic therapy is performed by a low-frequency sinusoidal alternating magnetic field. The exposure covers a collar zone and liver for 10-15 minutes. A continuous mode, frequency 50 Hz, grade I-II magentic induction are specified. The magnetic therapy is immediately followed by the exposure to complex-modulated pulse electric current with a neural-like pulse shape. The exposure is generated at the level ThVII - ThXI, paravertebrally to the right, and cover skin projections within the liver and gallbladder transversally. For this purpose, the electrodes are placed in 6 procedure fields: 1 - paravertebrally to the right at the level of the ThVII spine, 2 - paravertebrally to the right at the level of the ThXI spine, 3 - in a projection of the liver on a front surface of the body, 4 - in a projection of the liver on a back surface of the body, 5 - in a projection of the gallbladder on the front surface of the body, 6 - in a projection of the gallbladder on the back surface of the body. The 1st and 2nd electrodes are connected to the channel IV, while the 3rd and 4th electrodes - to the channel I, and the 5th and 6th electrodes are connected to the channel II. The channels I, II work in a frequency-drift group mode. The channel IV work in a continuous mode at fixed frequency 20 Hz. The current intensity is adjusted to apparent vibration sensation. Duration of a session is 10-15 minutes. The therapeutic course is 10-12 daily procedures.

EFFECT: method improves the motor function of the gall bladder ensured by the improved cholekinesis, hepatic circulation and cholestasis elimination.

2 ex, 3 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, namely a method for preparing an agent possessing anticoagulant, hypotensive and diuretic action. The method for preparing the agent possessing anticoagulant, hypotensive and diuretic action, consisting in the fact that milled dark mullein is extracted in 60% ethanol by re-percolation in a cluster of 3 unequally batched percolators; the prepared extract is settled, filtered, boiled down and dried in a vacuum drier in the certain environment.

EFFECT: agent prepared by the above method possess pronounced anticoagulant, hypotensive and diuretic action.

4 tbl

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to cardiology, and may be used for treating and preventing arterial hypertension with metabolic syndrome. That is ensured by adding the food ration with the functional foodstuff 'Samarskiy Zdorovyak' No 61 in a min daily dose of 33.3 g per one intake - with breakfast or lunch or dinner with underlying drug-induced therapy.

EFFECT: enabled treatment and prevention of arterial hypertension with metabolic syndrome

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, namely to a method for preparing water-soluble fractions of mannoproteins and β-glucan. A method for preparing the water-soluble fractions of mannoproteins and β-glucan consisting in the fact that yeast biomass is prepared by mechanical activation in activators and mills; the prepared mechanical complex is added with a solution of enzymic complex showing β-glucanase or protease activity; that is followed by hydrolysis; the prepared hydrolysate is divided into mannoprotein and β-glucan fractions to be subject to purification under certain conditions.

EFFECT: method provides the more effective hydrolysis and higher yield of the end product.

2 cl, 4 dwg, 10 ex

FIELD: medicine.

SUBSTANCE: invention refers to veterinary gynaecology, particularly to treating acute postpartum endometritis in cows, and can find application in dairy farms and complexes. A method of treating acute postpartum endometritis in cows involves the intrauterine administration of an antimicrobial agent with the antimicrobial agent being presented by an emulsion consisting of sterile sunflower oil, the preparation ASD-3 and oxytetracycline, prepared of sterile sunflower oil 1000 ml added with the preparation ASD-3 35 ml and oxytetracycline-200 30 ml; the prepared suspension is kept at a room temperature for one day; before the administration, the emulsion is heated to temperature 38-39°C and administered in a dose of 110-150 ml per one animal 2-3 times every 48 hours.

EFFECT: method enables the higher therapeutic effectiveness in acute postpartum endometritis in cows by 25-30%, makes the treatment 8 days shorter.

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a composition for local application for treating vaginitis of various origins and related inflammatory inflammations. The above composition contains benzophenanthridine alkaloids, benzofuran compounds and optionally Zanthoxylum bimgeanum or Echinacea angustifolia extract.

EFFECT: composition possesses antibacterial, antifungal and antienzymic activity and reduces vaginal infections fast, eliminates the presence of saprophytes, relieves inflammation, itch and vaginal pH.

12 cl, 3 tbl, 1 ex

FIELD: medicine, oncology, amino acids.

SUBSTANCE: invention relates, in particular, to the development of an antitumor preparation based on natural substances. Invention relates to an amino acid preparation comprising at least one modified essential amino acid obtained by treatment of amino acid by ultraviolet radiation (UV) at wavelength 250-350 nm for 12-80 h at temperature 15-30oC or with ozone at temperature 15-25oC. The modified amino acid has no toxicity for health cells. Also, invention relates to a method for preparing such preparation. Invention provides the development of an antitumor preparation based on modified amino acids and expanded assortment of antitumor preparations being without cytotoxicity for normal cells.

EFFECT: valuable medicinal antitumor properties of preparation.

8 cl, 4 tbl, 2 dwg, 4 ex

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