Compositions and devices

FIELD: medicine.

SUBSTANCE: combined dental whitening and oral therapeutic composition for delaying and inhibiting dental caries, delaying or inhibiting demineralisation and promoting dental remineralisation. The composition contains an effective amount of a whitening agent and arginine in a salt form in the amount of 0.1 wt % to 50 wt % with the whitening agent and arginine dispersed in a matrix material.

EFFECT: improved properties of the composition.

17 cl, 11 ex

 

For this application claims the priority of patent application U.S. registration No. 61/027429, filed February 8, 2008, the contents of which are incorporated into this description by reference.

The level of technology

Products for teeth whitening are known in the art, and include devices and methods that provide without a prescription or professionally. One device used for whitening mouthguard, which is applied to whitening composition and then apply it on the teeth. See, for example, U.S. patent No. 5746598 and 5376006, the contents of which are incorporated into this description by reference. Another device for whitening strip is applied on the surface of the teeth. See, for example, U.S. patents 5891453, 6436297, 5879691, 6277458, 5894071, the contents of which are incorporated into this description by reference. Other devices for bleaching are liquid gels for teeth whitening, as described in U.S. patent 6669930, publications of the U.S. 2005/0038181 and WO 2002/032961, the contents of which are incorporated into this description by reference. While the use of these devices can lead to teeth whitening, they are usually not used to treat the oral cavity other evidence. Indeed, such devices may also aggravate some diseases of the oral cavity. For example,people, wearing such devices can be prone to keep your mouth open, thereby causing increased evaporation of saliva, resulting in dry mouth.

While the use of such products can lead to teeth whitening, there is a need to develop compositions that can whiten your teeth and treat the oral cavity, for example, to slow down or inhibit the occurrence of dental caries, reduce or inhibit demineralization and promote remineralization of the teeth, and/or to treat dryness of the mouth.

The invention

The compositions of the present invention can contribute to or improve the oral hygiene and/or General health status, including the status of the cardiovascular system, for example, reducing the possibility of generalized infection through the tissues of the mouth.

The present invention relates to compositions and devices that carry out the delivery of basic amino acids, e.g. arginine, into the oral cavity together with the bleaching agent for teeth whitening, and, for example, (i) slow down or inhibit the occurrence of dental caries, (ii) attenuate, restore or inhibit precariously damage to the enamel, e.g., as determined by quantitative fluorescence induced by light (QLF), or diagnosis of caries with the use of e is aktionscode measurement (ECM), (iii) reduce or inhibit demineralization and promote remineralization of the teeth, (iv) reduce hypersensitivity of the teeth, (v) facilitate or inhibit gingivitis, (vi) promote healing of sores or cuts in the mouth, (vii) reduce the number kislotoproduktsiya bacteria, (viii) increase the relative amount of alginolyticus bacteria, (ix) inhibit the formation of microbial biofilms in the oral cavity, (x) raise and/or maintain plaque pH at a value of at least pH 5.5, after the sugar samples (xi) slow the accumulation of plaque on the teeth, (xii) brush my teeth and mouth, (xiii) are subjected to immunization teeth against cariogenic bacteria, (xiv) improve overall health, including the state of the cardiovascular system, for example, by reducing the possibility of generalized infection through the tissues of the oral cavity, (xv) slow erosion and/or (xvi) treat, relieve or reduce dry mouth. These compositions and devices can be used separately or in combination with other compositions containing basic amino acids, for example, compositions for cleaning teeth, for the delivery of basic amino acids in the mouth.

Arginine and other basic amino acids proposed to care for the oral cavity, and it is believed that they have a significant beneficial effect in combating the appearance of cavities and tooth sensitivity. Considered is t, that basic amino acids in the oral cavity are metabolized by certain types of bacteria, such as S. sanguis, which are not cariogenic, and which compete with cariogenic bacteria such as S. mutans, for space on the teeth and in the mouth. Alginolyticus bacteria can apply arginine and other basic amino acids for the synthesis of ammonia, whereby increasing the pH of their environment, whereas cariogenic bacteria metabolize sugar, synthesizing lactic acid, reducing the pH of plaque and demineralize the teeth, eventually leading to the formation of cavities. In addition, basic amino acids such as arginine, promote remineralization of the teeth, helping to repair damage and clogging the microtubules associated with the sensitivity of the teeth. Many patients complain of hypersensitivity of the teeth after bleaching, possibly due to the fact that bleaching chemical substances can irritate the nerve endings in microtronic.

Thus, the present invention includes a composition 1.0 for teeth whitening, containing

A. an effective amount for teeth whitening can whiten your teeth by contact means for whitening teeth, and

b. the basic amino acid in free or salt form.

The present invention is that the same includes the following songs:

1.1 Composition 1.0, in which the basic amino acid is an arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutane acid, diaminopropionic acid, their salts and/or their combinations.

1.2 Composition 1.0 or 1.1, in which the basic amino acid is L-configuration.

1.3 Any of the preceding compositions, in which the basic amino acid is an arginine.

1.4 Any of the preceding compositions, in which the basic amino acid is an L-arginine.

1.5 Any of the preceding compositions containing the basic amino acid is in salt form.

1.6 Any of the preceding compositions containing phosphate arginine.

1.7 Any of the preceding compositions containing arginine hydrochloride.

1.8 Any of the preceding compositions containing percarbonate arginine.

1.9 Any of the preceding compositions containing the arginine bicarbonate.

1.10 Any of the preceding compositions containing from about 0.1% to about 50% by weight of basic amino acids.

1.11 Any of the preceding compositions, optionally containing matrix material.

1.12 Any of the preceding compositions, in which the means for whitening the teeth and the basic amino acid is distributed in a matrix material.

1.13 Any of the preceding compositions, more is tion containing carboxypolymethylene.

1.14 Any of the preceding compositions, optionally containing a matrix material containing the reaction products of carboxypolymethylene.

1.15 Any of the preceding compositions containing polyvinylpyrrolidone.

1.16 Any of the preceding compositions, optionally containing a matrix material having adhesiveness and/or resistance to dilution by saliva such that when the composition for teeth placed in a mouthguard for teeth and a mouth guard for teeth are placed over the teeth, the composition for teeth will hold the mouthguard for teeth in position over the teeth, for example, within at least about 1, 2, 3, 4 or 5 hours without significant pressure mouthguards for teeth.

1.17 Any of the preceding compositions, optionally containing water.

1.18 Any of the preceding compositions, optionally containing glycerin.

1.19 Any of the preceding compositions, optionally containing polyethylene glycol.

1.20 Any of the preceding compositions having a pH from about 5 to about 12.

1.21 Any of the preceding compositions having a pH of approximately 6,1.

1.22 Any of the preceding compositions, in which the means for whitening the teeth is chosen from the group consisting of peroxides, metal chlorite, perborates, percarbonates, peroxyketal, hypochlorites, and combinations thereof.

1.23 Any of the preceding compositions, in which a bleaching agent is hydrogen peroxide or a source of hydrogen peroxide, for example, urea peroxide or a peroxide salt or complex (such as peroxyborate, peroxocarbonate, perborate, proximality or persulfate salt; for example, proxyport calcium, perborate sodium, carbonatebased sodium, proxyport sodium and potassium persulfate), or hydroperoxide polymer complexes, such as hydrogen peroxide-polyvinylpyrrolidone polymer complexes.

1.24 Any of the preceding compositions containing carbamide peroxide, perborate sodium, percarbonate sodium and/or hydrogen peroxide.

1.25 Any of the preceding compositions in which the pH is regulated basis, selected from triethanolamine, sodium hydroxide, or basic amino acids.

1.26 Composition 1.25, in which the basic amino acid is an arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutane acid, diaminopropionic acid, their salts and/or their combinations.

1.27 Composition 1.25 or 1.26, in which the basic amino acid is in free or salt form selected from hydroxide, hydrochloride, bicarbonate, phosphate, and/or combinations thereof.

1.28 Composition 1.27, in which the basic amino acid is chosen is from arginine bicarbonate and hydroxide arginine.

1.29 Any of the preceding compositions, optionally containing a fluoride salt selected from tin fluoride, sodium fluoride, potassium fluoride, monophosphate sodium, fertilitate sodium, fertilitate ammonium, amino, ammonium fluoride, and combinations thereof.

1.30 Any of the preceding compositions containing an antibacterial agent selected from halogenated diphenyl ether (e.g., triclosan), extracts of herbs and essential oils (e.g., rosemary extract, tea extract, Magnolia extract, thymol, menthol, eucalyptus, geraniol, carvacrol, citral, hinokitiol, catechol, methyl salicylate, epigallocatechine gallate, epigallocatechin, gallium acid, extract of miswak extract, sea buckthorn), bis-guanidine antiseptics (e.g., chlorhexidine, alexidine or octenidine), Quaternary ammonium compounds (for example, cetylpyridinium (CPC), benzylaniline, tetraacetylethylenediamine (TPC), N-tetradecyl-4-ethylenedichloride (TDEPC)), phenolic antiseptics, hexetidine, octenidine, sanguinarine, iodopovidone, delmopinol, califlour, metal ions (e.g., zinc salts, e.g. zinc citrate, salts of tin, copper salts, iron salts), sanguinarine, propolis and oxidizing agents (e.g. hydrogen peroxide, buffered peroxyborate sodium or peroxicare is that), phthalic acid and its salts, monophthalmos acid and its salts and esters, ascorbinsaeure, oleoresin, alkylsulfate, dioctylsulfosuccinate, salicylanilide, domainbased, delmopinol, Octafinal and other piperidinovyh derivatives, drugs Nizina, chloritic salts; and mixtures of any of the foregoing.

1.31 Any of the preceding compositions which is a gel.

Another aspect of the implementation of the present invention is a method of whitening teeth in a patient, comprising applying any one of compositions 1.0-1.31 on the tooth, for example, in the form of a film. The composition can be dried, and the dried composition can be attached to the tooth, for example, 1-30 minutes before removing or destruction to the tooth surface.

Another variant of implementation of the present invention includes a method of whitening teeth in a patient, comprising a frame for delivery, which shall be of such dimensions to cover the surface of the teeth that have been bleached, coated with any one of compositions 1.0-1.31, the location of the frame above the teeth so that at least part of compositions 1.0-1.31 was in contact with the surface of the teeth that need whitening, keeping them in position over the teeth for at least one hour and remove the mouth guard from the teeth. Frame for delivery may be in the form of trays, the de Kappa shape to hold a certain amount of any one of compositions 1.0-1.31. Frame for delivery may be in the form of a tape, for example, a flexible tape where compositions 1.0-1.31 form a film on one side of the tape to be applied on the teeth. In another embodiment, the framework for delivery may be of such a size to cover more than one tooth.

Other embodiments of the present invention will be clear to experts in the given field of technology.

DETAILED DESCRIPTION of the PRESENT INVENTION

"Effective amount" is an amount that is sufficient to provide the desired therapeutic or prophylactic effect in the oral cavity without undue adverse side effects such as irritation or allergic reaction.

Unless otherwise indicated, as used in the present invention, the basic amino acid comprises a basic amino acid in free base form or salt form.

Whitening treatments known in the art and include any material safe for use in the oral cavity, which provides a bleaching or removing plaque. Suitable agents include peroxides, metal chlorites, perborates, percarbonates, peroxyacids, and combinations thereof. Suitable peroxide compounds include hydrogen peroxide, calcium peroxide, carbamide peroxide, and mixtures thereof. Coming up is their metal chlorites include chlorite calcium, the barium chlorite, magnesium chlorite, sodium chlorite and potassium chlorite. Suitable sources of hydrogen peroxide include, for example, urea peroxide or a peroxide salt or complexes (e.g., such as peroxyborate, peroxycarbonates, perborate, peroxynitrate or persulfate salts; for example, proxyport calcium, perborate sodium, carbonatebased sodium, proxyport sodium and potassium persulfate), or hydroperoxide polymer complexes, such as hydroperoxide polyvinylpyrrolidone polymer complexes. The effective concentration of tooth whitening are also known in the art as an effective processing time.

Basic amino acids that can be used in the compositions of the present invention include not only naturally occurring basic amino acids such as arginine, lysine and histidine, but also any basic amino acids containing in the molecule a carboxyl group and an amino group. Accordingly, the basic amino acids include, but are not limited to, arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutane acid, diaminopropionic acid, their salts, or a combination. In a specific embodiment, the basic amino acid selected from arginine, citrulline and ornithine, preferably arginine, n is the sample, l-arginine.

As used in the present invention, the reference to the primary amino acid also includes a salt thereof. Because the compositions and devices of the present invention are intended for use in the oral cavity, salts for use in the present invention should be safe for this application, in prescribed quantities and concentrations. Usually consider that a suitable salt, including salt, are known in the art that they are pharmaceutically suitable salts, are suitable in prescribed quantities and concentrations. Physiologically acceptable salts include salts derived from pharmaceutically acceptable inorganic or organic acids or bases, for example, salts of accession acid formed by the acid, which forms a physiologically acceptable anion, for example, or cleaners containing hydrochloride bremena salt, and salt joining the Foundation, formed by the bases, which form a physiologically acceptable cation, for example, salts derived from alkali metals such as sodium and potassium, or alkaline earth metals such as calcium and magnesium. Physiologically acceptable salts can be obtained using standard methods known in the art, for example, by the reaction of a sufficiently basic compound such as an amine with a suitable acid, giving a physiologically acceptable anion.

The compositions of the present invention contain an effective amount of basic amino acids. Thus, the composition may contain from about 1% to about 50% by weight of basic amino acids, for example, approximately 1, 2, 3, 4, 5, 10, 15, 20, 25, 30, 35, 40 or 45%.

The compositions of the present invention can optionally be suspended in the matrix. Suitable matrix materials are safe for use in the oral cavity, and they should not quickly dissolve in the mouth, and should not react with the remedy for teeth whitening or a basic amino acid.

Matrix materials are known in the art and usually consist of swelling in water of the polymers, such as carboxypolymethylene, carboxymethylcellulose, karboksimetilcelljuloza, poloxamer, carragenan, Wigan, carboxyvinyl polymers, polyvinylpyrrolidone and natural gums such as gum karaya, xanthan gum, guar gum, Arabia gum, tragacanth gum and mixtures thereof.

One preferred matrix material is carboxypolymethylene. Previously, it was determined that saturated carboxypolymethylene aqueous composition having a concentration of carboxypolymethylene equal to from about 3.5% to about 12%, about adut high viscosity and they can get a song for teeth with a slow release. Because the compositions of the present invention may contain non-aqueous or water-insoluble components, the concentration of carboxypolymethylene may be greater, for example, from about 15% to about 35%.

Carboxypolymethylene can be available from various sources, including B.F. Goodrich Company under the trade name CARBOPOL, such as CARBOPOL 934P and CARBOPOL 940.

It is found that carboxypolymethylene can be mixed with glycerin, which allows dispersing in water a large amount of carboxypolymethylene. The amount of glycerol in these compositions are known in the art, for example, from about 20% to about 70% by weight. Glycerin can optionally be replaced by polypropylene, sorbitol, glycols or other polyols.

The presence of carboxypolymethylene can reduce the pH of the compositions of the present invention. In order to avoid low pH values, which can erode tooth enamel and prevent the beneficial effect of basic amino acids, the compositions of the present invention may have a pH in the range from approximately 5 to 12, for example, from about 5.5 to about 6.5, for example, approximately 6,1. The pH of the compositions can be adjusted to any base known in the art that it is physiologically p is memlimit given final concentrations for example, sodium hydroxide or triethanolamine, or a basic amino acid or its salt.

Another preferred matrix is polyvinylpyrrolidone, see U.S. patent No. 6730316, the content of which is incorporated into this description by reference.

Preferably, the basic amino acid and any of the other ingredients evenly distributed in the matrix, even if these materials are insoluble in the matrix.

The compositions of the present invention are suitable for direct application on one or more teeth, for example, in the form of a thin film. The film is attached to the tooth, and stand on the tooth surface within 1-30 minutes before removing or destruction.

The compositions of the present invention can be applied to one or more teeth with frame for delivery, such as Kappa or tape, both of which are known in the art.

When frame for delivery is a mouthguard for teeth, mouthguards give this form to keep a certain amount of any one of the compositions of the present invention, for example, from about 0.5 to about 5 ml. Mouthguards for teeth are known in the art as methods for their production. Usually mouthguards for teeth give in this form, so she came to the mouth of the patient, and the content is La canal, suited for putting on on one or more teeth. The compositions of the present invention is usually distributed in the channel and then a mouthguard for teeth attach to the teeth.

When frame for delivery is the tape composition for tooth whitening of the present invention can be applied or cover tape. These tapes for teeth are known in the art as methods for their production. Tapes usually have the flexibility and rigidity, which allows them to bend and take a curved shape around a single tooth or several teeth. The tape may also have shallow wells to provide containers for the whitening composition. Usually viscous and sticky properties of the whitening composition allows you to attach the ribbon with two sides to the same or adjacent teeth. However, the viscosity is low enough to provide easy removal of the tape by the patient by peeling the tape material.

In one embodiment, the present invention composition can optionally contain an effective amount of fluoride or source of fluoride ions, e.g., a soluble fluoride salt. A great variety of substances, providing fluoride ions, can be used as sources of soluble fluoride in the present compositions. Examples of suitable substances, providing the actual operation of fluoride ions, presented in U.S. patent No. 3535421, Briner et al.; U.S. patent No. 4885155, Parran, Jr. et al., and U.S. patent No. 3678154, Widder et al., included in this description by reference.

Examples of sources of fluoride ions include, but are not limited to, tin fluoride, sodium fluoride, potassium fluoride, monitoroff sodium, forcricket sodium, forcricket ammonium, aminopterin, ammonium fluoride, and combinations thereof. In certain embodiments of the implementation of a source of fluoride ions include tin fluoride, sodium fluoride, monitoroff sodium, as well as mixtures thereof.

In certain embodiments of the implementation arrangement for the care of the oral cavity of the present invention may also contain a source of fluoride ions or ingredient containing fluorine in amounts sufficient to provide from about 25 ppm to 25,000 ppm of fluoride ions, usually at least about 500 parts per million, for example, from about 500 to about 2000 parts per million, for example, from about 1000 to about 1600 ppm, for example, approximately 1450 ppm. The proper concentration of fluoride ions will depend on the particular application. Liquid for rinsing the mouth, for example, would typically contain from about 100 to about 250 parts per million of fluoride ions. Sonapost for primary use by the consumer would typically contain from about 1000 to about 1500 parts per million, while children's toothpaste could contain several smaller amount of fluoride ions. Means for brushing or coating for professional application could contain up to 5000 or even 25,000 parts per million of fluoride ion.

The sources of fluoride ions can be added to the compositions of the present invention at a concentration equal to from about 0.01% by weight to about 10% by weight in one embodiment, or from about 0.03% by weight to about 5% by weight in another embodiment, or from about 0.1% by weight to about 1% by weight of the composition in another embodiment. Weight of fluoride salts to obtain a suitable concentration of fluoride ions will, obviously, vary depending on the weight of the counterion in the salt.

In another embodiment, the present invention composition can optionally contain an antiseptic, antimicrobial or antibacterial agent, and an agent selected from halogenated diphenyl ether (e.g., triclosan), extracts of herbs and essential oils (e.g., rosemary extract, tea extract, Magnolia extract, thymol, menthol, eucalyptus, geraniol, carvacrol, citral, hinokitiol, catechol, methyl salicylate, epigallocatechine gallate, epigallocatechin, Galiev the th acid, extract of miswak extract, sea buckthorn), bis-guanidine antiseptics (e.g., chlorhexidine, alexidine or octenidine), Quaternary ammonium compounds (for example, cetylpyridinium (CPC), benzylaniline, tetraacetylethylenediamine (TPC), N-tetradecyl-4-ethylenedichloride (TDEPC)), phenolic antiseptics, hexetidine, octenidine, sanguinarine, iodopovidone, delmopinol, califlour, metal ions (e.g., zinc salts, e.g. zinc citrate, salts of tin, copper salts, iron salts), sanguinarine, propolis and oxidizing agents (e.g. hydrogen peroxide that buffered peroxyborate sodium or peroxocarbonate), phthalic acid and its salts, monophthalmos acid and its salts and esters, ascorbinsaeure, oleoresin, alkylsulfate, dioctylsulfosuccinate, salicylanilide, domainbased, delmopinol, Octafinal and other piperidinovyh derivatives, drugs Nizina, chloritic salts; and mixtures of any of the foregoing.

The composition can further comprise an agent that inhibits or prevents the adhesion of bacteria, for example, Cabral or chitosan.

In another embodiment, the present invention compositions may optionally contain anti-inflammatory agents such as nonsteroidal anti-inflammatory drugs.

Composers the AI of the present invention can also contain corrigentov. Flavouring substances used in the practice of the present invention include, but are not limited to, essential oils, as well as various flavoring aldehydes, esters, alcohols, and similar substances. Examples of essential oils include peppermint oil Koloskova, peppermint, Wintergreen, sassafras, clove, sage, eucalyptus, marjoram, cinnamon, lemon, lime, grapefruit and orange. Also suitable are chemical compounds, such as menthol, carvon and anethole. Suitable corrigentov may also include sweeteners, such as Sucralose, aspartame, saccharin. The compositions of the present invention may also contain dyes.

Improved oral hygiene also has a beneficial effect on overall health, because the tissue of the oral cavity can be by means of penetration for generalized infection. The hygiene of the oral cavity associated with the total health status, including the status of the cardiovascular system. Compositions and methods of the present invention have specific beneficial effects, as basic amino acids, especially arginine, are sources of nitrogen, which is involved in the synthesis of NO and, thus, increases microcirculation in the tissues of the oral cavity. Reducing the acidity of the oral cavity is also one the Xia useful for alleviating gastrointestinal disorders and creates conditions less favorable for heliobacteria that are associated with gastric ulcer. In particular arginine is required for high expression of specific receptors of the immune system cells, for example, receptor T-cells, so that arginine may enhance effective immune response. Thus, the compositions and methods of the present invention are suitable for improving overall health, including the state of the cardiovascular system.

As used in the present invention, the ranges are used as the legend for a description of all values that are within a given range. Any value from the given range you can choose the limits of this range. In addition, all references in the present invention, when incorporated fully by reference. In case of contradiction of the definition of the present description and definitions in the cited reference, the present description has the advantage. It is clear that when they describe the compositions, they can be described on the basis of their ingredients, as typically performed in the art, despite the fact that these ingredients can react with each other in the real part at least of their receipt, storage and application, and assumes that these products are covered by the described compositions.

Following the E. additional examples describe and demonstrate given to illustrate embodiments of the scope of the present invention. Examples are given for purposes of illustration, and should not be construed as limiting the present invention since many possible options, not beyond the scope and essence of the invention. Various modifications of the present invention in addition to the modifications shown and described in the present invention, will be apparent to experts in the art, and it is assumed that they are included in the accompanying claims.

EXAMPLE 1

The composition for whitening of the teeth is produced by mixing the following ingredients:

remedy for teeth whitening10%
essential amino acid50%
water40%

EXAMPLE 2

25 g of salt of L-arginine was added to 50 g of water, getting a suspension. 5 g of 10% solution of carbamide peroxide was added to this suspension, and the suspension was applied to the removed tooth in vitro. The composition was washed after 2 hours of treatment, and the tooth was found to be more white in color when compared on a scale of shades.

EXAMPLE 3

25 g of bicarbonate of L-arginine was added to 50 g of water, getting a solution. 5 g of 10% solution of carbamide peroxide was added to this solution, and yellowed delete the config tooth smoker (about 25 cigarettes a day without a visit to the dentist-hygienist for 5 months) was immersed in the solution in vitro. The composition was washed after 2 hours of treatment, and the tooth was found to be more white in color when compared on a scale of shades.

EXAMPLE 4

A composition for whitening teeth were obtained by mixing the following components

carbamide peroxide10%
water21%
glycerin57%
CARBOPOL R7%
Salt L-arginine5%

EXAMPLE 5

The pH value of the composition of example 4 was brought to 10 with concentrated sodium hydroxide solution.

EXAMPLE 6

The pH value of the composition of example 4 was brought to 9 40% hydroxide solution of arginine.

EXAMPLE 7

The pH value of the composition of example 4 was brought to 8 60% solution of bicarbonate of arginine.

EXAMPLE 8

1 g of triclosan was added to 99 g of the composition of example 4 or 7.

EXAMPLE 9

The composition of examples 4, 5, 6, 7 and 8 were added to the mouthguard for teeth sufficient to cover the teeth number. The Kappa attached to the upper teeth of the patient for 3 hours and then removed. Did the conclusion that teeth treated with composition, were more white after treatment when compared on a scale of shades.

The EXAMPLE 10

Liquid helium composition for bleaching was obtained by mixing the following ingredients:

The basic formula liquid gel for whitening
Ingredientweight%
WaterEnough
The carbopol1,00
95% ethyl alcohol34,80
Glycerin5,00
PEG 60010,00
PEG 2M14,00
Hydrogen peroxide25,00
85% phosphoric acid0,05
Monotony sodium phosphate0,05
Phosphate arginine5
The total number of100

EXAMPLE 11

Sensitivity the second pressure-adhesive gel composition for bleaching was obtained by mixing the following ingredients:

The ingredients of the composition (in grams)AB
BIO pressure-sensitive silicone adhesive (high viscosity)*30,030,0
Plastigel3434
Percarbonate sodium25-
PVP H2O2cx**-25,0
Saccharin0,800,50
Corrigent14,00
PEG 400--
Polyisobutene--
The arginine bicarbonate10,010,0
*Dissolved in 60% by weight of Dimethicone.
**cx = cross-stitched polyisobutene.

1. A composition comprising an effective amount for bleaching teeth and arginine in a salt form in an amount of from 0.1% to 50% by weight, in which the means for whitening the teeth and arginine dispersed in a matrix material.

2. The composition according to claim 1, in which the effective amount for bleaching teeth ranges from 10% to 25% by weight, arginine has the L-configuration, and the remedy for teeth whitening is selected from peroxides, chlorides, metals, perborates, percarbonates, peroxyketal and their combinations.

3. The composition according to claim 1, in which arginine is in salt form that is selected from the group consisting of phosphate arginine, arginine hydrochloride, percarbonate arginine and arginine bicarbonate, and the remedy for teeth whitening is selected from the group consisting of carbamide peroxide, sodium perborate, percarbonate sodium, hydrogen peroxide, or combinations thereof.

4. The composition according to claim 3, in which the matrix material contains carboxypolymethylene.

5. The composition according to claim 3, containing polyvinylpyrrolidone.

6. The composition according to claim 1, in which the matrix material has a sticky and/or resistance to dilution by saliva such that when the composition for teeth placed in a mouthguard for teeth and a mouth guard for teeth are placed over the teeth, the composition for teeth will hold the mouthguard for teeth in position over obami without significant pressure, provide mouthguards for teeth.

7. The composition according to claim 1, additionally containing water.

8. The composition according to claim 1, additionally containing glycerin.

9. The composition according to claim 1, additionally containing polyethylene glycol.

10. The composition according to claim 1, having a pH from 5 to 12.

11. The composition of claim 10 having a pH of 6.1.

12. The composition according to claim 11, having a pH from 7 to 9.

13. The composition according to claim 3, additionally containing a fluoride salt selected from tin fluoride, sodium fluoride, potassium fluoride, monophosphate sodium, fertilitate sodium, fertilitate ammonium, amino, ammonium fluoride, and combinations thereof.

14. The composition according to claim 3, additionally containing an antibacterial agent selected from halogenated diphenyl ether, the extracts of medicinal herbs and essential oils, bis-guanidine antiseptics, Quaternary ammonium compounds, phenolic antiseptics, hexetidine, octenidine, sanguinarine, iodopovidone, delmopinol, califlour, metal ions, sanguinarine, propolis and oxidizing agents, phthalic acid and its salts, monophthalmos acid and its salts and esters, ascorbinsaeure, oleoresin, alkylsulfate, dioctylsulfosuccinate, salicylanilide, domainbased, delmopinol, Octafinal and other piperidinovyh derivatives, drugs Nizina, chloritic salts; and mixtures of any of above.

15. The composition is according to claim 5, which is a gel.

16. The composition according to 14, where
halogenated diphenyl ether is a triclosan;
herbal extracts and essential oils are rosemary extract, tea extract, Magnolia extract, thymol, menthol, eucalyptus, geraniol, carvacrol, citral, hinokitiol, catechol, methyl salicylate, epigallocatechingallate, epigallocatechin (EGC), gallium acid, extract of miswak extract of sea buckthorn;
bis-guanidine antiseptics are chlorhexidine, alexidine and actinidin;
the Quaternary ammonium compounds are cetylpyridinium (CPC), benzylaniline, tetraarylporphyrin (TPC) and N-tetradecyl-4-ethylpyridinium (TDEPC);
metal ions are zinc salts, salts of tin, salts of copper and iron salts;
oxidizing agents are hydrogen peroxide, buffered peroxyborate sodium and peroxycarbonates.

17. The composition according to item 16, where the zinc salt is a zinc citrate.



 

Same patents:

FIELD: medicine.

SUBSTANCE: wet wipe for cleansing the skin or hair of a user comprises: a wipe substrate and a single-phase liquid composition containing from 0.05% (by weight of the composition) to 50% (by weight of the composition) of at least one water dispersible silicone and from 50% (by weight of the composition) to 99.95% (by weight of the composition) of water. Silicon represents modified sorbitan siloxane having the following structure 1, wherein R1 represents an alkyl group having 7 to 21 carbon atoms, R2, R3 and R4 are independently specified in a group consisting of H and structure 2, wherein at least one of the radicals R2, R3 or R4 represents structure; a is an integer ranging from 0 to 200; b is an integer ranging from 1 to 10; z is an integer ranging from 1 to 10; c is an integer ranging from 0 to 10; d is an integer ranging from 5 to 20; n is an integer ranging from 7 to 17; e is an integer ranging from 0 to 30; f is an integer ranging from 0 to 30; g is an integer ranging from 0 to 30, wherein the sum of e, f, and g is an integer ranging from 9 to 50; and wherein the ratio of hydroxyl to carboxyl group ranges from 4:1 to 2:1.

EFFECT: invention provides user's pleasant sensations, improves the skin and hair with using no hard surfactants.

20 cl, 7 ex, 8 tbl

FIELD: medicine.

SUBSTANCE: invention relates to cosmetology and represents regenerating composition for skin care which contains regulator pH-triethanolamine, BAA, base Salcare SC80, cyclomethicone DC345, preservative, odorant, water, which is characterised by the fact, that as biologically active additive it contains protein substance from quail egg and antioxidant, and base includes UV-filter, olive oil, glycerin, emulsifier Solubilisant LRL preservative Sharomix MCI an purified water, and components in composition are in specified ratio in wt %.

EFFECT: invention ensures moistening and protection of skin from ultraviolet irradiation, as well as, regeneration, increase of tone and elasticity of skin.

3 ex, 2 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutics and cosmetology and concerns a heparanase activity inhibitor containing a cyclic carboxamide derivative being an active ingredient and presented by formula (I) or a salt thereof to be used as an anti-wrinkle or skin lightening agent.

EFFECT: developing the anti-wrinkle or skin lightening agent.

6 cl, 13 dwg, 2 tbl, 6 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to cosmetic industry and represents a cosmetic preparation containing water-dispersible polyurethane with linear main chains generally consisting of alternating hydrophilic and hydrophobic sections; herewith: a) both terminal sections (T) are hydrophibic and at least one of both sections (T) are a branched alkyl residue, b) a hydrophilic section (S) is attached to each section immediately (T), c) at least one hydrophobic section (D) is attached to at least one end of each section (S) immediately, and d) the main chain contains at least one hydrophilic section (P), if there are more than one sections (P) are provided, two sections (P) are divided by at least one hydrophobic section (D).

EFFECT: invention provides creating the cosmetic preparations having the improved viscosity maintained for longer periods of time.

9 cl, 13 ex, 4 tbl

Anti-wrinkle agents // 2503443

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to chemical-pharmaceutical industry and represents wrinkle-reducing agents containing compounds presented by general formula (1), stereoisomers or pharmacologically acceptable salts thereof, wherein R1 represents a hydrogen atom or a linear or branched alkyl group with 1-8 carbon atoms; R2 represents -SH, -SO3H, -S-X2, -SO-X3, -S02-X4, X2-X4 represents carbon atoms or aliphatic hydrocarbon groups with 1-8 carbon atoms independently, R3 represents a hydrogen atom or an acyl group with a linear or branched alkyl chain with 1-8 carbon atoms, R4 represents a phenyl, tolyl, ethyl phenyl, propyl phenyl, butyl phenyl, pentyl phenyl, hexyl phenyl, methoxyphenyl, ethoxyphenyl, propyl oxyphenyl, butyl oxyphenyl, pentyl oxyphenyl, hexyl oxyphenyl or biphenyl group, m is equal to 0, n is equal to the integer 1 or 2.

EFFECT: invention provides preparing the compounds and cosmetic products possessing the anti-wrinkle effectiveness.

10 cl, 11 ex, 2 tbl, 7 dwg

FIELD: medicine.

SUBSTANCE: invention refers to methods of treating early enamel loss. The presented method of treating or reducing early enamel caries involves the dental application of an effective amount of a dental composition wherein the dental composition has a main formulation containing dicalcium phosphate, wherein the dental composition additionally contains arginine in the free or salt form, and an effective amount of fluoride, wherein arginine is found in the amount of 2 to 10 wt % of total weight of the dental composition.

EFFECT: composition used in the method possess an ability to increase enamel demineralisation that enables treating or reducing early enamel caries.

3 cl, 1 tbl, 4 ex

FIELD: chemistry.

SUBSTANCE: invention relates to field of cosmetology and represents preparation for removing nail polish, which contains organic solvent, cosolvents and target additives characterised by the fact that propylene glycol is used as organic solvent, mixture of ethyl alcohol, ethyl acetate, propylene carbonate, dimethyl glutarate, isopropyl alcohol are used as cosolvents, and mixture of glycerol, gelatin, jojoba oil and denatonium benzoate is used as target additive, with components in preparation being in specified wt % ratio.

EFFECT: invention ensures creation of preparation for removing nail polish without unpleasant smell, with wide spectrum of efficient effect on different types of manicure polishes, as well as characterised by restoring impact on nails, and impossibility of accidental intake as food.

1 ex

FIELD: medicine.

SUBSTANCE: invention refers to cosmetology and represents a cosmetic skin care product in the form of a water-in-oil emulsion, containing: (A) a volatile hydrocarbon oil 3 to 25 wt %, (B) a non-volatile silicon oil 2 to 15 wt %, (C) polyethylene glycol mono- or diisostearate 0.1 to 0.8 wt % containing 4 to 12 groups of oxyethylene, (D) polyoxyethylene and polydimethyl siloxyehtyl dimethicone copolymer 1 to 5 wt %, an d (E) organically modified clay mineral 1.5 to 3 wt %; the ingredients normally introduced into the skin care products - the rest.

EFFECT: provided excellent stability and no oily, slick and creaking sensations.

6 cl, 3 ex, 4 tbl

FIELD: medicine.

SUBSTANCE: invention refers to cosmetology and represents a cosmetic product for lips containing the ingredients (a)-(d): (a) hydrogenised polyisobutene 10 to 30 wt %; (b) one or more methylphenylsicicones 30 to 70 wt % to be separated when mixed with (a) at 25°C specified in trimethyl pentaphenyltrisiloxane, diphenyl siloxyphenyl trimethicone, diphenyl dimethicone and phenyl trimethicone, and containing trimethyl pentaphenyl trisiloxane; (c) one or more lipophilic substrates 0.5 to 8 wt % not separated when mixed both with the ingredient (a), and with the ingredient (b) at 90°C specified in sorbitane sesquiisostearate, propylene glycol monostearate, cetyl-PEG/PPG-10/1 dimethicone and diglycerol diisostearate; and (d) wax 5 to 12 wt %.

EFFECT: provided excellent effect of second adhesion stability immediately after application, long-lasting gloss and stability.

10 cl, 22 ex, 1 dwg, 13 tbl

FIELD: medicine.

SUBSTANCE: invention refers to chemical-pharmaceutical industry and represents a method of delivering a substance from an antiperspirant and/or deodorant composition to an individual's axillary space, involving the application of the anhydrous antiperspirant and/or deodorant composition onto the individual's axillary space, wherein: a) the anhydrous composition contains a base and a metal-organic frame structure formed of reusable porous material (RPM) and a substance adsorbed in the metal-organic frame structure and b) the reusable porous material has a structure degradable in contact with water and releasing a substance with the metal-organic frame structure formed of the porous material (RPM) specified in a groupu consisting of [Co3(biphenyldicarboxylate)34,4'-bipyridine], [Co(biphenyldicarboxylate)(4,4'-bipyridine)], [Zn2(biphenyldicarboxylate)2 (1,2-bipyridineethene)], Mg3(O2C-C10-H6-CO2)3 and combinations thereof.

EFFECT: provided longer release of a flavouring agent after the application of the deodorant/antiperspirant to the individual by the release of the flavouring agent at the moment of perspiration.

16 cl, 2 tbl

FIELD: medicine.

SUBSTANCE: wet wipe for cleansing the skin or hair of a user comprises: a wipe substrate and a single-phase liquid composition containing from 0.05% (by weight of the composition) to 50% (by weight of the composition) of at least one water dispersible silicone and from 50% (by weight of the composition) to 99.95% (by weight of the composition) of water. Silicon represents modified sorbitan siloxane having the following structure 1, wherein R1 represents an alkyl group having 7 to 21 carbon atoms, R2, R3 and R4 are independently specified in a group consisting of H and structure 2, wherein at least one of the radicals R2, R3 or R4 represents structure; a is an integer ranging from 0 to 200; b is an integer ranging from 1 to 10; z is an integer ranging from 1 to 10; c is an integer ranging from 0 to 10; d is an integer ranging from 5 to 20; n is an integer ranging from 7 to 17; e is an integer ranging from 0 to 30; f is an integer ranging from 0 to 30; g is an integer ranging from 0 to 30, wherein the sum of e, f, and g is an integer ranging from 9 to 50; and wherein the ratio of hydroxyl to carboxyl group ranges from 4:1 to 2:1.

EFFECT: invention provides user's pleasant sensations, improves the skin and hair with using no hard surfactants.

20 cl, 7 ex, 8 tbl

FIELD: food industry.

SUBSTANCE: method involves preliminary milling of berries into particles sized 2-5 mm; then berries surface treatment with enzyme preparations. Before ultrasound exposure one performs the components soaking in well or purified water during 6-8 hours at a temperature of 35-40°C, after treatment one proceeds with the extract cooling and filtration.

EFFECT: method allows to produce an extract with enhanced biological activity, nutritive value and bactericidal effect and to increase the extractive, flavouring and colouring substances yield.

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely physiotherapy. A method involves the administration of chophytol, diet therapy, magnetic therapy and exposure to electric current. The magnetic therapy is performed by a low-frequency sinusoidal alternating magnetic field. The exposure covers a collar zone and liver for 10-15 minutes. A continuous mode, frequency 50 Hz, grade I-II magentic induction are specified. The magnetic therapy is immediately followed by the exposure to complex-modulated pulse electric current with a neural-like pulse shape. The exposure is generated at the level ThVII - ThXI, paravertebrally to the right, and cover skin projections within the liver and gallbladder transversally. For this purpose, the electrodes are placed in 6 procedure fields: 1 - paravertebrally to the right at the level of the ThVII spine, 2 - paravertebrally to the right at the level of the ThXI spine, 3 - in a projection of the liver on a front surface of the body, 4 - in a projection of the liver on a back surface of the body, 5 - in a projection of the gallbladder on the front surface of the body, 6 - in a projection of the gallbladder on the back surface of the body. The 1st and 2nd electrodes are connected to the channel IV, while the 3rd and 4th electrodes - to the channel I, and the 5th and 6th electrodes are connected to the channel II. The channels I, II work in a frequency-drift group mode. The channel IV work in a continuous mode at fixed frequency 20 Hz. The current intensity is adjusted to apparent vibration sensation. Duration of a session is 10-15 minutes. The therapeutic course is 10-12 daily procedures.

EFFECT: method improves the motor function of the gall bladder ensured by the improved cholekinesis, hepatic circulation and cholestasis elimination.

2 ex, 3 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, namely a method for preparing an agent possessing anticoagulant, hypotensive and diuretic action. The method for preparing the agent possessing anticoagulant, hypotensive and diuretic action, consisting in the fact that milled dark mullein is extracted in 60% ethanol by re-percolation in a cluster of 3 unequally batched percolators; the prepared extract is settled, filtered, boiled down and dried in a vacuum drier in the certain environment.

EFFECT: agent prepared by the above method possess pronounced anticoagulant, hypotensive and diuretic action.

4 tbl

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to cardiology, and may be used for treating and preventing arterial hypertension with metabolic syndrome. That is ensured by adding the food ration with the functional foodstuff 'Samarskiy Zdorovyak' No 61 in a min daily dose of 33.3 g per one intake - with breakfast or lunch or dinner with underlying drug-induced therapy.

EFFECT: enabled treatment and prevention of arterial hypertension with metabolic syndrome

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, namely to a method for preparing water-soluble fractions of mannoproteins and β-glucan. A method for preparing the water-soluble fractions of mannoproteins and β-glucan consisting in the fact that yeast biomass is prepared by mechanical activation in activators and mills; the prepared mechanical complex is added with a solution of enzymic complex showing β-glucanase or protease activity; that is followed by hydrolysis; the prepared hydrolysate is divided into mannoprotein and β-glucan fractions to be subject to purification under certain conditions.

EFFECT: method provides the more effective hydrolysis and higher yield of the end product.

2 cl, 4 dwg, 10 ex

FIELD: medicine.

SUBSTANCE: invention refers to veterinary gynaecology, particularly to treating acute postpartum endometritis in cows, and can find application in dairy farms and complexes. A method of treating acute postpartum endometritis in cows involves the intrauterine administration of an antimicrobial agent with the antimicrobial agent being presented by an emulsion consisting of sterile sunflower oil, the preparation ASD-3 and oxytetracycline, prepared of sterile sunflower oil 1000 ml added with the preparation ASD-3 35 ml and oxytetracycline-200 30 ml; the prepared suspension is kept at a room temperature for one day; before the administration, the emulsion is heated to temperature 38-39°C and administered in a dose of 110-150 ml per one animal 2-3 times every 48 hours.

EFFECT: method enables the higher therapeutic effectiveness in acute postpartum endometritis in cows by 25-30%, makes the treatment 8 days shorter.

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a composition for local application for treating vaginitis of various origins and related inflammatory inflammations. The above composition contains benzophenanthridine alkaloids, benzofuran compounds and optionally Zanthoxylum bimgeanum or Echinacea angustifolia extract.

EFFECT: composition possesses antibacterial, antifungal and antienzymic activity and reduces vaginal infections fast, eliminates the presence of saprophytes, relieves inflammation, itch and vaginal pH.

12 cl, 3 tbl, 1 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a composition for oral hygiene and for treating and preventing pathological conditions related to the dentofacial system, implants and complications following the oral surgeries. The above composition contains benzophenanthridine alkaloids, benzofuran compounds and catechine polyphenols.

EFFECT: composition possesses antibacterial, antifungal and antienzymic activity that exceeds total activities of the different ingredients if used separately.

14 cl, 2 tbl, 1 ex

Iimmunomodulator // 2504371

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, namely to an immunomodulator. An immunomodulator for the immunocorrection accompanying the integrated treatment of chronic non-specific pulmonary diseases, chronic obstructive pulmonary disease, bronchial obstruction syndrome, chronic bronchial pneumonia, pulmonary fibrosis, tracheobronchitis, chronic laryngitis, pulmonary, tracheal and pharyngeal cancer; the immunomodulator is prepared by mixing a water infusion of rose bay leaves and a water infusion of yellow melilot taken in equal proportions, with a cattle lung and larynx powder, settling the prepared mixture, keeping on a boiling water bath, cooling; further, the mixture is filtered; the prepared solution is added with cattle blood serum containing leukaemia oncovirus antibodies, hemlock infusion, ascorbic and sorbic acids until all the ingredients fully dissolved; the prepared solution is placed in the water bath, cooled, filtered, sterilised under certain conditions.

EFFECT: above preparation provides higher effectiveness and reduces the length of treating the above diseases, and ensures the higher immunobiological properties of the human body.

3 ex

FIELD: medicine, oncology, amino acids.

SUBSTANCE: invention relates, in particular, to the development of an antitumor preparation based on natural substances. Invention relates to an amino acid preparation comprising at least one modified essential amino acid obtained by treatment of amino acid by ultraviolet radiation (UV) at wavelength 250-350 nm for 12-80 h at temperature 15-30oC or with ozone at temperature 15-25oC. The modified amino acid has no toxicity for health cells. Also, invention relates to a method for preparing such preparation. Invention provides the development of an antitumor preparation based on modified amino acids and expanded assortment of antitumor preparations being without cytotoxicity for normal cells.

EFFECT: valuable medicinal antitumor properties of preparation.

8 cl, 4 tbl, 2 dwg, 4 ex

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