Method of treating patients with hypomotor dysfunction of gallbladder. RU patent 2504411.
| Hepatoprotective herbal tea / 2500418 Invention refers to pharmaceutical industry, particularly to a hepatoprotective herbal tea. The hepatoprotective herbal tea that contains black currant leaves, red raspberry leaves, great willow herb, meadowsweet herb in certain proportions. |
 Incapsulated hepatocyte composition / 2500390Invention refers to pharmaceutical industry, namely to a microcapsules for preventing or treating hepatic disorders. The microcapsules for preventing or treating hepatic disorders containing a capsule coating, an encapsulating suspension of a therapeutically effective hepatocyte count in a physical contact with a hepatocyte-stimulating amount of erythropoietin. A method for preparing microcapsules involving preparing the suspension of the therapeutically effective hepatocyte count and the hepatocyte-stimulating amount of erythropoietin to bring them in physical contact with each other, and encapsulating the suspension of hepatocytes and erythropoietin in a biologically compatible capsule shell so that to form a microcapsule. A method for preventing or treating a hepatic disorder in an individual in need thereof involving administering the microcapsules in the individual in need thereof. The method for introducing the hepatocytes in the individual involving administering the microcapsules in the individual. A method for hepatocyte culture in a culture medium involving hepatocyte culture in the microcapsules in the appropriate culture medium. |
 Method of treating non-alcoholic steatohepatitis (nash) with using cysteamine products / 2498795Group of inventions refers to treating fatty liver degeneration. The method of treating a patient suffering fatty liver degeneration involves administering a therapeutically effective amount of cysteamine or cystamine, or a pharmaceutically acceptable salt thereof as a part of a composition. The method of treating the patient suffering non-alcoholic fatty liver degeneration (NAFLD) or non-alcoholic steatohepatitis (HASH) involves administering the therapeutically effective amount of the composition containing cysteamine or cystamine, or the pharmaceutically acceptable salt thereof. In both methods, the composition may be presented by a delayed or controlled release dosage form containing an enteric coating and providing the improved delivery of cysteamine or cystamine, or the pharmaceutically acceptable salt thereof. |
| Immunomodulator / 2497514 Invention refers to chemical-pharmaceutical industry, and represents an immunomodulator for treating chronic hepatitis, hepatic cancer, lymphatic sarcoma, chronic leukemia, and for improving the functions of liver and blood-forming organs, for enhancing the immunobiological body characteristics, prepared by mixing 1000 ml of an aqueous infusion of sandy everlasting blossom, pepper mint herb and chicory herb with 50 ml of bovine serum containing leukaemia oncovirus antibodies, 20 ml of wild rosemary infusion, 40 g of ascorbic acid, 2 g of sorbic acid, 0.2 g of folic acid until the ingredients are dissolved completely, with adding 60 g of liver powder, 30 g of lymphatic node powder, 30 g of young bovine spleen powder; the prepared solution is settled at room temperature for 24 hours, then kept at a boiling water bath for 30 minutes and cooled for 6-8 hours at room temperature; the settled solution is filtered, wherein the aqueous herbal solution is prepared by mixing equal proportions of the separately prepared aqueous infusions of 40 g of pepper mint herb in 1000 ml of water, 30 g of sandy everlasting blossom in 1000 ml of water and 30 g of chicory herb in 1000 ml of water, while the wild rosemary infusion is prepared by infusing 60 g of ground wild rosemary blossom in 1000 ml of 70% purified ethanol. |
 Method of treating viral hepatitis c / 2496512Group of inventions refers to medicine, namely to gastroenterology and may be used for treating hepatitis C. For this purpose, an effective amount of glutaryl histamine or a pharmaceutically acceptable salt thereof is introduced into the patient. The above agent may be administered in a combination with pegylated interferon and ribavirin. The group of inventions also refers to a pharmaceutical composition for treating viral hepatitis C. This group of inventions enables disclosing a new drug preparation having a manifested antiviral effect and being effective in treating viral hepatitis C. |
| Method of treating visceras / 2495683 Invention relates to medicine, namely to methods of treating diseases of various aetiologies and injuries of various visceras. Electropunctural pre-examination aims at determining the patient's overall potential and the potential in a point on the body surface at a minimal distance from the viscera to be treated, or in its immediate projection tender zones. A stem cell growth area is stimulated by placing a bee within the sternum. Then, an irritation centre is created using vacuum- or hirudotherapy in a point on the body surface at a minimal distance from the above viscera or in its immediate projection tender zones. The irritation centre is created to be intensive and short-term at the level of the potential in the point below the overall potential, or to be weak and long-term at the level of the potential in a point above the overall potential. |
| Method for preventing and treating liver dystrophy in cattle / 2494759 Invention relates to therapy of internal non-infectious diseases, particularly to compositions for preventing and treating liver dystrophy in cattle. An agent for preventing and treating liver dystrophy in cattle contains an antihepatotoxic serum and an antispleenotoxic serum; the serums are pre-processed in acidic and enzymatic hydrolysis at pH 3.9-4.0 and pepsin concentration 49-51 mg per protein 100 g for 17.5-18.5 hours at temperature 37-38°C; then hydrolised serums are mixed with sterile saline, preserved phenol concentrated 0.4-0.5% at 1.0 ml thereof, the antihepatotoxic serum - 9.0-11.0 titre units and the antispleenotoxic serum - 9.0-11.0 titre units. |
| Synergetic preparation for treating cardiovascular diseases, diabetes mellitus and hepatobiliary diseases / 2493841 Invention refers to a synergetic preparation for treating cardiovascular insufficiency, types I and II diabetes mellitus, hepatobiliary diseases, containing a combination of a pharmaceutically acceptable salt of 2-ethyl-6-methyl-3-pyridin-3-ole and taurin in the amount of 2-75% and pharmaceutically acceptable carriers, excipients and additives with the mass ratio of the active ingredients of the combination making 9:1 to 1:9. The preparation may be presented in the form of a tablet, a capsule or a solution for injections. The invention also refers to a method of treating cardiovascular insufficiency, types I and II diabetes mellitus, hepatobiliary diseases wherein the therapeutically effective amount of the synergetic preparation is administered to the patient. |
 Treating fibrotic diseases / 2491934Present group of inventions refers to medicine, namely therapy, and concerns treating fibrotic diseases. That is ensured by administering 40-O-(2-hydroxy)ethylrapamycin or a pharmaceutical composition thereof in the effective amount. |
 Pharmaceutical composition containing 1,2-dithiol-thione derivative for preventing or treating diseases mediated by high lxr-alpha expression / 2491065Invention refers to pharmaceutics and medicine, and concerns a pharmaceutical composition for preventing and treating diseases mediated by high expression or high activity of liver X receptor (LXRa), high expression or high activity of a sterol regulatory element-binding protein-1c (SREBP-1). |
| Method for integrated physiotherapeutic treatment and prevention of recurrent urolithiasis / 2502532 Invention refers to medicine, namely - to physiotherapy, urology. A method involves the integrated physiotherapeutic effect of three physical factors. The ultrasonic exposure is characterised by frequency 2.7 kHz + 0.2 kHz, length 9 ms, pulse period 200 ms. The exposure to magnetic field is characterised by magnetic induction amplitude 1300 mT, pulse period 80 ms. The laser exposure is characterised by power 5.0 Wt, frequency 80 Hz. Total duration of a procedure is 30 minutes. |
| Method of treating encephalopathy in children / 2501584 Invention refers to medicine, namely - to physiotherapy, paediatrics and neurology. The patient is exposed to a EEG-assisted combination of a magnetic field and laser light. The exposure involves a running magnetic field in a continuous mode. The inductance is 6-40 mT, and frequency is 50 Hz. The exposure involves laser light at wave length 0.85-0.9 mcm, frequency 50 Hz, power 3.5-5 mWt. The exposure is bitemporal along the spinal column at the level of C1-L1. Duration of a procedure is 10-12 minutes. The procedures are daily. The therapeutic course is 10 procedures. |
| Method of treating patients with acute ischemic stroke / 2500441 Invention refers to medicine, namely - to neurology. With underlying integrated therapy, the daily transcranial magnetic stimulation is generated by Neuro-MS apparatus. The exposure involves the contact coils IK-02-150 to be placed above a projection of the ischemic centre; the session length makes 1-2 minutes; the pulse train interval is 3 seconds; the train length is 3 seconds; the simulation frequency is 5 Hz, while the magnetic pulse induction peak makes 20%. The coil IK-02-150 is used to exposure the hemisphere opposite to the ischemic centre with the session length of 1-2 minutes, the pulse train interval of 3 seconds, the train length of 3 seconds, the simulation frequency of 0.1 Hz, and the magnetic pulse induction peak of 20%. A left frontal region is exposed to the coil IDU-02-100. The session length is 1-2 minutes, the pulse train interval is 5 seconds; the train length is 2.5 seconds. The simulation frequency is 10 Hz, and the magnetic stimulation peak is 20%. The procedures are daily; the therapeutic course is 10 procedures. |
| Method for electromagnetic stimulation of central and peripheral nerve system / 2499614 Invention refers to medicine, namely to neurosurgery and rehabilitation medicine. A principal stage of the surgical intervention is followed by placing at least one electrode for neuromodulation in an abnormal focus. In the postoperative period, the Kronlein - Brusova scheme is used to localise a projection of anterior central gyri on the head skin, and the transcranial Doppler sonography follows. The presence and location of the temporal and suboccipical window are stated. It is the temporal window the closest to a projection of the anterior central gyri that is selected. Local magnetic emitters are placed in projections of the selected temporal and suboccipital windows. That is combined with the local exposure to the magnetic field by means of the placed emitters and electric current through the electrodes for neurostimulation. The 10-15-minute stimulation is performed three times a day for 15-20 days. |
 Magnetic therapy apparatus / 2496533Invention refers to medicine, more specifically to magnetic therapy, and may be used in healthcare facilities and domiciliary. Substance of the invention consists in the fact that a magnetic therapy apparatus comprises a time-varying current generator and an inductor connected to the current generator; the current generators is a flicker noise current generator, and the inductor is flat, rectangular and comprises four segments of a ribbon cable and four junction plates which are arranged between two identical rectangular solid segments and fixed in between; the flicker noise current generator is provided in an outer pocket clipped on the outer surface of the upper segment of solid tissue in the lower corner portion. In the particular case, the magnetic therapy apparatus is presented in the form of a bedcover. |
 Method for generating magnetotherapeutic exposure and device for implementing it / 2496532Invention refers to medical equipment, namely to agents for integrated magnetotherapy. The method consists in placing along the patient's body, above and below it, two layers of identical units in the form of electromagnetic filed generators, supplying electric signals of adjustable frequency and porosity thereto through control units from a control computer. Each electromagnetic field generator consists of a three-component inductor, which together with bridge current drivers, a local control device in the form of a microcontroller, and with the connected circuits of thermometers and current and magnetic field intensity probes, represents a unit cell being a part of one of the twelve unit cell matrixes with the personal address. The control computer selects the driving unit cell among the identical unit cells to generate a clock signal for the driven unit cells. There are formed three signal sets each of which comprises a impulse ratio modulation signal and a polarity signal to provide the individual exposure to magnetic field from the unit cells. The device implements the method for generating the magnetotherapeutic exposure and generating the common magnetotherapeutic medium. |
| Method of treating luetic optic neuropathy / 2494775 Invention relates to medicine, namely to ophthalmology, and can be used for treating luetic optic neuropathy. That is ensured by subconjunctival administration of Cefazolin 0.3-0.5 mg. That is combined with intramuscular injection of Gliatilin 2.0-4.9 ml, 1-3% Glutoxim 2.0 ml and Milgamma 1.0-2.0 ml. Dexazon 0.5 ml is introduced parabulbarly. The preparations are introduced once a day for 10 days. Additionally, starting with the first therapeutic day, 10 sessions of percutaneous transcranial magnetic stimulation of the optic nerves are conducted daily. |
| Method of treating progressing myopia in children / 2494708 Invention relates to medicine, namely to ophthalmology and pediatrics, and can be used for treatment of progressing myopia in children. For this purpose homeopathic medication placenta compositum is introduced into acupuncture points BL1 (UB1), ST1, EX-HN7(QIUHOU), GB1, EX-HN4(YUYAO) in dose 0.2 ml into each point. After that head area is subjected to exposure to pulse low-frequency electromagnetic field (PLEMF). Course of treatment constitutes 10 procedures, performed every second day. |
 Method for late rehabilitation of patients suffering osteoarthrosis following total hip replacement / 2493890Invention refers to medicine, namely to - physiotherapy, balneology. A method involves the exposure to a low-frequency pulse magnetic field. The exposure covers 6 fields. If the exposure covers the 1st and 2nd fields, including paravertebral muscles, the mode B is used. The exposure consists of single pulses of the pulse duration for S inductor 110±10 mcs, for N inductor 260±20 mcs. Pulse length is 16 Hz, and intensity is 70-80%. The inactive N inductor is placed on the side of more evident pain sensations. Length of the exposure is 3 minutes. If the exposure covers the 3rd-6th fields including projections of the gluteus medius muscle and rectus muscle of thigh, the mode A is used. The exposure consists of paired pulses. The pulse duration for S inductor is 110±10 mcs, and for N inductor 260±20 mcs. Intensity is 80-100%. An inter-pulse interval is 40 ms. The active S inductor is placed within a projection of the gluteus medius muscle and rectus muscle of thigh in its lower one-third from the side of the surgically operated joint. The inactive N inductor is placed on a posterior thigh in its lower one-third and a projection of the rectus muscle of thigh in its upper one-third. The exposure length for the 3rd-4th and 5-6th fields makes 3 minutes for each. Total duration of a procedure is 9 minutes. The procedures are daily. The therapeutic course is 10-12 procedures. Pelotherapy by applications of peat mud onto the paravertebral lumbar spine and a projection of hip joints follows 60-90 minutes later. Mud temperature is 38 - 40°C. Duration of a procedure is 20-30 minutes. The procedures are performed every second day. The therapeutic course is 8-10 procedures. The method improves body self-adaptation ensured by optimising the immune system functioning, the lipid peroxidation system and antioxidant protection. |
| Method of treating vertebral compression in children / 2489180 Invention refers to medicine, namely - to physiotherapy and traumatology. According to the method, the initially prone patient is exposed to a traveling pulse magnetic field generated by ALMAG apparatus. Inductor coils are arranged in contact along the spine within a projection of the compression fracture. That is followed by induction of 20 mT. The exposure length is specified according to a child's age. When treating the 8-11-year-old children, the exposure length is 8 minutes, while the 12-14-year-old children are treated for 10 minutes. The procedures are daily. The therapeutic course is 8-10 procedures. Starting from the 3-5th day, the daily course of therapeutic exercises is prescribed. The therapeutic course is 8-10 procedures. |
| Method for rehabilitation of patients suffering deforming arthrosis of knee joints / 2502500 Invention refers to medicine, namely to - arthrology, physiotherapy, balneology. The method involves physical methods of therapy, therapeutic exercises, massage, acupuncture and phytotherapy. The patients are trained to give a self-massage of the knee joints additionally during the resort therapy and after the termination of the rehabilitation. From the 1st to 10th day of the therapeutic course patient's knee joint is exposed to polychromatic polarised light at 20 cm for 6 minutes. The patients take 10 iodine-bromine baths at temperature 37°C for 10 minutes. From the 1st to 5th therapeutic days, the patients do combined therapeutic exercises; their lower extremities are massaged manually for 10 minutes. From the 6th to 15th days, the knee joints are exposed to sinusoid modulated currents (SMC) at modulation frequency 100 Hz, at a depth of 50 - 70%, current intensity to moderate vibration for 7 minutes. From the 6th to 10th days, the braking acupuncture follows by giving a 1-2-minute massage of the points 10RP, 9RP, 36E, 34E by introducing a needle for 30 seconds and by giving a point massage of cheng-fu, cuan, yang-lin-cuan, zu-sang-li, wei-yang, cheng-shan, chung-feng, hun-lun, nei-ting. The patients take a herbal infusion. From the 11th to 15th days, the knee joints are exposed to decimetric waves (DMW). That is followed by a hydro-massage of the lower extremities and lumbar region for 15 minutes up to 3 atm. Thereafter, the 10-minute post-isometric relaxation of the quadriceps muscle of thigh is applied. The patients do the complex of weight reduction exercises and take the herbal infusion. From the 16th to 20th day, the mud applications on the knee joints are prescribed at temperature 42°C for 30 minutes. If suffering gonarthrosis, the patients do the complex of therapeutic exercises. That is followed by the paravertebral vacuum therapy of the vertebral column. The 10-minute knee joint traction is applied. The patients take 20 g of the herbal infusion. |
FIELD: medicine.
SUBSTANCE: invention refers to medicine, namely physiotherapy. A method involves the administration of chophytol, diet therapy, magnetic therapy and exposure to electric current. The magnetic therapy is performed by a low-frequency sinusoidal alternating magnetic field. The exposure covers a collar zone and liver for 10-15 minutes. A continuous mode, frequency 50 Hz, grade I-II magentic induction are specified. The magnetic therapy is immediately followed by the exposure to complex-modulated pulse electric current with a neural-like pulse shape. The exposure is generated at the level ThVII - ThXI, paravertebrally to the right, and cover skin projections within the liver and gallbladder transversally. For this purpose, the electrodes are placed in 6 procedure fields: 1 - paravertebrally to the right at the level of the ThVII spine, 2 - paravertebrally to the right at the level of the ThXI spine, 3 - in a projection of the liver on a front surface of the body, 4 - in a projection of the liver on a back surface of the body, 5 - in a projection of the gallbladder on the front surface of the body, 6 - in a projection of the gallbladder on the back surface of the body. The 1st and 2nd electrodes are connected to the channel IV, while the 3rd and 4th electrodes - to the channel I, and the 5th and 6th electrodes are connected to the channel II. The channels I, II work in a frequency-drift group mode. The channel IV work in a continuous mode at fixed frequency 20 Hz. The current intensity is adjusted to apparent vibration sensation. Duration of a session is 10-15 minutes. The therapeutic course is 10-12 daily procedures.
EFFECT: method improves the motor function of the gall bladder ensured by the improved cholekinesis, hepatic circulation and cholestasis elimination.
2 ex, 3 tbl
The invention relates to medicine, namely, physiotherapy, and can be used for the treatment of patients with dysfunction of the gallbladder.
In the complex treatment of functional disorders of the gastrointestinal tract with insufficiency of motor function apply the low-frequency magnetotherapy [for an invention patent RU №2357768]. The method of treatment of patients with functional constipation hypotonic type. The continually shifting inductor-electromagnet on the skin of the anterior abdominal wall in the projection of the colon.
According to the authors of the proposed method, magnetotherapy by the given method is not effective enough, as the focal impact of the magnetic field can have only a local effect, improving the blood circulation of the colon, slimming swelling, increasing the excitability and conductivity of nerve fibers of the colon, but not has a normalizing effect on the autonomic nervous system. It is known that in the regulation of muscle tone gallbladder participate sympathetic and parasympathetic nervous system. When sympathicotonia tone walls and motor function body are reduced. The magnetic field has a corrective effect by reducing the activity of the sympathetic and increase of activity of the parasympathetic autonomic nervous system.
According to the literature, low-frequency magnetotherapy used to provide effect hypertension [Miloslavsky D.K. Clinical and pathogenetic basis of efficiency with hypertension: Avtoref. Dis. kand. honey. Sciences. - Kharkov, 1995]. Under the influence of the method is the amplification of the parasympathetic nervous system. However, the techniques of using the specified physical factor to correction of the function of the autonomic nervous system in dysfunction of the gallbladder in the available literature is not detected. Low frequency magnetic field is applied in the treatment of patients with biliary diseases as reparative-regenerative method [Physiotherapy: national manual / edited by G.N. Ponomarenko. - M: GEOTAR-Media, 2009. - 864 C. .420].
For the treatment of patients with dysfunction apply the methods of physiotherapy, providing action: drinking treatment of mineral waters, amplipulse therapy [Ponomarenko, G.N. Zolotareva T.A. Physical methods of treatment in gastroenterology. - SPb.: IPC «Baltika», 2004. - 287 ..227]; drinking treatment of mineral waters, probing changes, electrostimulation of the gallbladder and biliary tract sinusoidal modulated currents [Physiotherapy: national manual / edited by G.N. Ponomarenko. - M: GEOTAR-Media, 2009. - 864 C. .420-421]. With the purpose of rendering influence recommended electric shocks: transcranial , transcranial electrostimulation, electrosleep, interference therapy, amplipulse therapy [Physiotherapy: national manual / edited by G.N. Ponomarenko. - M: GEOTAR-Media, 2009. -864 ..420, 402].
To achieve effect using chloride-sulfate, sodium-magnesium, mineral drinking water Essentuki # 4 and 17, , Borjomi, , , Moscow, Izhevsk, Б and other Time is dependant on the kislotoobrazoutei the stomach. Water temperature 36-45°With, starting with 100 ml and gradually increasing up to 200-250 ml 3-4 times a day (depending on the mode of supply) small SIPS, slowly, a course of treatment in the outpatient 28-40 days [Ponomarenko, G.N. Zolotareva T.A. Physical methods of treatment in gastroenterology. - SPb.: IPC «Baltika», 2004. - 287 C. .232].
The disadvantage is the large duration of treatment and the lack of influence on the function of the autonomic nervous system.
For the treatment of patients with biliary dyskinesia hypotonic type applied sinusoidal modulated currents affect the area of projection of a gall bladder, apply II mode, current PP (II kind of work), modulation frequency of 10 Hz, the depth of the modulation 50-75%, current - up to the light vibration, 10 minutes, the duration of 10 procedures carried out daily [Ponomarenko, G.N. Zolotareva T.A. Physical methods of treatment in gastroenterology. - SPb.: IPC «Baltika», 2004. - 287 C. .232].
Electrostimulation of the gallbladder by the mentioned method is not effective enough, as is impact on one procedural field, excluding dystonia of the autonomic nervous system and circulatory disorders of the liver.
Application with purpose of transcranial impacts of different types of low-frequency electrotherapy is not efficient enough because of the large number of contraindications, the presence of the patient's discomfort (tingling) under the electrodes due to irritation of the skin products of electrolysis (action DC), short period of aftereffect (up to 2-3 months).
As a prototype very close to the technical nature of chosen method of treatment of patients with biliary diseases, including dysfunction of the gallbladder. Way is the impact of low frequency magnetic field on the epigastric region. Methodology alopecia, , mode continuous, pulse form sinusoidal, frequency 50 Hz, induction of 20-25 MT, duration 10-15 minutes, the 10 daily routines [Physiotherapy: national manual / edited by G.N. Ponomarenko. - M: GEOTAR-Media, 2009. -864 ..420, 403].
The disadvantage of the prototype is not sufficiently high efficiency, there is a therapeutic physical factor, regulation of activity of the gallbladder reflex occurs due to the effect on the secretory function of the stomach. Not that this has an impact on the motor activity of the gallbladder, impaired circulation to the liver.
Effect : enhanced efficiency of treatment of patients with dysfunction of the gallbladder by improving motor function of the gallbladder by improving , circulation of the blood in the liver and the elimination of the cholestasis.
The technical result of the invention is attained by the fact that on the background of the bile hofitol drug and diet spend magnetotherapy on the region of the neck area and liver low-frequency alternating magnetic field of sine-shaped form, using rectangular inductors, continuous mode, frequency of 50 Hz magnetic induction (I-II levels intensity for 10-15 minutes, then immediately perform multi-channel influence pulsed electric current with neural pulse shape at the level of the Th-VII-Th XI , paravertebral right, skin projection transversely in the liver and the gall bladder, using the 3 therapeutic channel, electrodes are set in 6 treatment fields: 1 - paravertebral right at the level of the VII Th vertebra, 2 - paravertebral right at the level of the XI Th vertebra, 3 - in the liver projection on the front surface of the trunk, 4 - in projection on liver the back surface of the trunk, 5 - in projection of a gall bladder on the front surface of the trunk, 6 - in projection of a gall bladder on the back surface of the trunk, and 1 and 2 electrodes connected to IV channel, 3 and 4 electrodes - to a channel I, 5 and 6 to the second channel, friendly way in the channel, mixed, i.e. I, II channels operate in batch mode with frequency drift, and IV channel - in continuous mode with fixed frequency - the frequency of 20 Hz, the period of migration of current through the channels 8, current - up feelings expressed vibration under the electrodes, the duration of electrostimulation 10-15 minutes; course treatment is 10-12 procedures, daily 1 procedure.
The method is as follows.
On the background of the bile hofitol drug and diet affect low-frequency alternating magnetic field of sine-shaped form on the region of the neck area and liver. Apply apparatus «pole-2M». Method of contact, and inductors-electromagnets with rectangular core feature in the neck area and in the projection of the liver. Mode continuous. Frequency 50 Hz. Magnetic induction - I-II degree. Duration of exposure 10-15 minutes. Then, immediately after this, that is, without a time interval, affect pulsed electric current with neural pulse shape at the level of the Th-VII - Th XI , paravertebral right, skin projection in the liver and gall bladder cross. Apply apparatus «-040». Use 3 therapeutic channel. Electrodes are set in 6 treatment fields: 1 - paravertebral right level vertebra Th VII ; 2 - paravertebral right level vertebra Th XI ; 3 - liver projection on the front surface of the body; 4 - in the liver projection on the back the surface of the body; 5 - a projection of a gall bladder on the front surface of the body; 6 - a projection of a gall bladder on the back surface of the trunk, and 1 and 2 electrodes connected to IV channel, 3 and 4 electrodes - to a channel I, 5 and 6 to the second channel, friendly mode of operation channels mixed, I and II channels - group with a drift frequency and IV channel - continuous with fixed frequency of 20 Hz, the period of migration of current through the channels 8, current - to the feeling expressed vibration under electrodes, duration of the procedure 10-15 min, the course of treatment is 10-12 procedures, daily 1 procedure.
Distinctive essential features of the invention and the causal links between them and achieve the result of the following.
- Carry out impact on the region and neck area and liver low-frequency alternating magnetic field of sine-shaped form, using rectangular inductors, continuous mode, frequency of 50 Hz magnetic induction (I-II levels of intensity for 10-15 minutes.
Impact on the region and the neck area and the liver can have a complex effect, because under the influence of magnetic field on the collar region there is the correction of functional disorders in the brain, and the autonomic nervous system, internal organs, and with focal impact is the activation of local blood flow, increased blood circulation and trophic liver.
Application of the magnetic field of sine-shaped form with a frequency of 50 Hz has a soft, gentle action, is used to influence the reflexogenic zones, sympathetic ganglia and contributes to the elimination of vegetative-vascular disorders, normalization and emotional condition and sleep.
The value of magnetic induction up to 30 MT (I-II stage), sufficient to impact on the vegetative nerve and liver tissue, has effect with the improvement of the hemorheological properties of blood.
- Immediately after the procedure magnetotherapy carry out multi-channel influence pulsed electric current with neural pulse shape at the level of the Th-VII-Th XI , paravertebral right, skin projection transversely in the liver and the gall bladder, using the 3 therapeutic channel, electrodes are set in 6 treatment fields: 1 - paravertebral right at the level of the VII Th vertebra, 2 - paravertebral right at the level of the XI Th vertebra, 3 - in the liver projection on the front surface of the trunk, 4 - in the liver projection on the back surface of the trunk, 5 - in projection of a gall bladder on the front surface of the trunk, 6 - in projection gall bladder on the back surface of the body.
Use pulse electric current with neural impulse shapes contributes to increasing the excitability and conduction of a nerve fibers, stimulation of nerve and vascular lesions of the gallbladder wall and improvement of motor-evacuation function of the gallbladder and the General condition of the patients.
Pulsed electric current with neural pulse shape is variable, the amount of electrical deviations momentum equal to zero, which shall ensure the elimination of arising under the action of the cathode emission electric asymmetries in the tissues on the surface of the current-carrying electrodes, softness and physiological impacts, prevention adaptation of tissues to the action of physical factor, good tolerability sick, no side effects.
The use of 3 therapeutic channels and the installation in 6 treatment fields allows us to provide a stimulating effect on the gall bladder muscles, circulation of the blood in the liver and reflex innervation of these bodies.
Regime friendly to the work of channels mixed, i.e. I and II channels operate in batch mode with frequency drift, and IV channel - in continuous mode with a fixed frequency of 20 Hz. Differentiated selection of the frequency (20 Hz) allows cause , vasodilatation. In drift mode frequency (auto-modulation) prevails irritant, the action of the current.
During the migration period of current through the channels 8, with lets get rate walls of a gall bladder close to physiological.
Impact pulsed electric current is carried out directly after exposure to low-frequency alternating magnetic field. Consistent, without time frame, the application of the procedures is one of the ways combination of physiotherapy (sequential therapy) and allows obtaining a synergy effect through the influence of factors on different stages of pathogenesis of the disease.
- The combined effect of low-frequency alternating magnetic field and pulsed electric shock by the present method allows us to provide comprehensive, pathogenetically grounded impact on the body as gall bladder dysfunction can develop when dystonia of the autonomic nervous system, which leads to an imbalance between sympathetic and pair-sympathetic influences, infringement of blood circulation and microcirculation in the liver.
- Length of procedures for magnetic therapy, and electrical stimulation for 10-15 minutes, and also a course of treatment is 10-12 procedures daily 1 procedure are sufficient to achieve a positive effect.
Set of distinctive essential features for a new and increases the efficiency of treatment of patients with dysfunction of the gallbladder by improving motor function of the gallbladder by improving , circulation of the blood in the liver and the elimination of the cholestasis.
Provide examples of their clinical practice.
Example 1. (The proposed method)
Patient M.K., 17 years. Diagnosis: gall bladder dysfunction.
Complaints about gravity in the right hypochondrium, bitterness in a mouth, bad breath, belching, electoral appetite, and fatigue.
Palpation is determined soreness in the area of , positive blistering symptoms. Liver +1.5 cm from under a costal arch, the edge of elastic.
Abdominal ultrasound - gallbladder increased in size, the pear-shaped form. The wall is thickened, in the lumen - thick wall bile.
- maximum degree of reduction of the gallbladder - 26%. Hypokinesia gallbladder.
Rheogeopathographia () - decrease of the common hepatic blood flow due to both its fractions (arterial and portal), lowering the tone of hepatic arterial vessels, slowing of portal blood flow, the stagnation of blood in the portal system of the liver.
Biochemical blood test: total bilirubin - of 28.64 umol/l, alkaline phosphatase 342,20 U/HP
- maximum degree of reduction of 46%. The norm.
On there is a significant improvement of hepatic blood flow through the normalization of arterial resistance vessels of the liver. In the biochemical analysis of blood - total bilirubin - 20,12 umol/l, alkaline phosphatase 230,10 U/HP
After discharge, within 6 months of exacerbations of pain syndrome was observed.
Clinical example of treatment by the method prototype
Patient LTD, 35 years. Diagnosis gall bladder dysfunction.
Sick for three years. Complaints of pain in the right hypochondrium, poor appetite, intolerance to fatty foods, dry language, a bitter aftertaste in the mouth, flatulence, unstable chair (alternating constipation and diarrhea).
On palpation of the abdomen was determined by the pain in the right hypochondrium, liver acted from under the edge of a costal arch to 1.0 cm identified positive blistering symptoms: Ortner, Kepa, Murphy.
Abdominal ultrasound - loose sludge in gall bladder.
- maximum Degree of reduction of the gallbladder - 29%. Hypokinesia gallbladder.
Violations in the biochemical analysis of blood: total bilirubin - 26,64 umol/l, alkaline phosphatase 400,40 U/HP
Rheogeopathographia () - decrease of the common hepatic blood flow through the portal of the faction, the deceleration of the portal blood flow, the stagnation of blood in the portal system of the liver.
After the course of treatment the patient has declined the complaint of pain and a feeling of gravity in the right hypochondrium, appetite improved, disappeared a bitter aftertaste in the mouth.
On palpation, liver acted from under the edge of a costal arch 0.5 cm, symptom Ortner negative symptoms Kera, Murphy positive normalized chair.
In the biochemical analysis of blood - total bilirubin - 22,14 umol/l, alkaline phosphatase 300,16 U/HP
Rheogeopathographia () no changes.
Clinical and laboratory complete remission has not been obtained. The patient is assigned therapy.
The proposed method of treatment of patients with dysfunction of the gallbladder is tested on 50 patients (I group) aged from 17 to 45 years. The comparison group (group II) consisted of 30 patients of the same age, have developed a method prototype. The effectiveness of treatment on the dynamics of clinical indicators of PDF and data in the main group was significantly higher than in the comparison group (96,0% and 50.0%, p<0.05).
Positive dynamics was observed in all patients. In group I patients, there was a reduction in pain 86.0 d%nausea 80,0 d%, flatulence by 56.0 d%, constipation 30.0 d%, asthenic complaints by 58.0 d%, whereas in group II respectively 56.7 d%66,7 d%30,0 d%16,6 d%43,3 d%. The disappearance of pain was observed in group I to 4,6 approximately 0.5 day, in group II to 10,3±0,8 day (P<0,05). Diarrhoeal phenomenon stoped respectively to 5.2±0,6 and 12.6±0,7 days (P<0.05). In the process of treatment was stopped cholestasis syndrome, however, only in group I, marked with the reliable positive dynamics of the level of bilirubin, including direct, and cholesterol in blood serum (table 1).
When conducting dynamic it was shown that treatment with the use of a combined physiotherapy was accompanied by a distinct positive changes in all the indicators of motor function of the gall bladder (table 2).
Improved hepatic hemodynamics (table 3).
Thus, the proposed method increases the effectiveness of treatment of patients with dysfunction of the gallbladder by improving motor function of the gallbladder by improving , circulation of the blood in the liver and the elimination of the cholestasis.
For the proposed method is characterized by the absence of adverse reactions, it is available to perform the average medical personnel, technically safe.
Method developed at the Department of physiotherapy and medical rehabilitation Department of public health and health care of North-West state medical University. I.I. Mechnikov and the Department of propedeutics of children's diseases with the course of the General care of children of Saint-Petersburg state pediatric medical Academy and was tested with positive results.
Table 1A dynamics of biochemical parameters of blood serum in patients with dysfunction of the gallbladder to the approbation of the proposed method and the treatment method prototype (Pitch m)
SignsGroup I, n=50
RGroup II, n=30
Rbefore treatment
after treatment
before treatment
after treatment
ACT, mkmol/l
0,54±0,02
0,28±0,02
<0,050,61±0,02
0,31±0,02
<0,05ALT, mkmol/l
0,81±0,06
0,40±0,05
<0,050,76±0,07
0,34±0,02
<0,05Total bilirubin, mkmol/l
18,90±0,41
12,60±1,23*
<0,0519,30±1,09
16,70±1,51
>0,05Direct bilirubin, mkmol/l
3,43±0,24
1,95±0,40*
<0,054,00±0,69
2,88±0,43
>0,05Total protein, g/l
72,40±0,92
78,60±0,90
<0,0574,10±1,30
75,10±0,98
>0,05Cholesterol-Rin mmol/l
5,72±0,05
4,06 ħ 0.09
<0,055,06±0,10
4,12±0,19
>0,05Alkaline phosphatase, U/l
361,18±86,33
162,50±69,34*
<0,05314,90±75,28
208,90±32,48
<0,05* - P I,II <0,05
Table 2Dynamics of indicators of motor-evacuation function of the gallbladder, in patients with approbation of the proposed method and the treatment method prototype (Pitch m)
SignsGroup I, n=50
pGroup III, n=30
pbefore treatment
after treatment
before treatment
after treatment
The initial volume, ml
139,5 ħ 5.1
72,4±2,3
<0,05128,4±4,3
85,1±2,9
<0,05The maximum registered reduction of the gall bladder, min
88,6 approximately 0.5
42,4±0,2*
<0,0583,4 approximately 0.5
71,8±0,3
>0,05The degree of maximum reduction, %
32,8 approximately 0.5
48,9±0,1
<0,0532,4±0,2
35,9±0,7
>0,05The relative speed of cholelithiasisderive %/min
0,42±0,05
0,82±0,03*
<0,050,41±0,05
0,45±0,04
>0,05* - P I,II <0,05
Table 3Dynamics of indicators of hemodynamics of the liver in patients with dysfunction of the gallbladder to the approbation of the proposed method and the treatment method of the prototype (Pitch m)
SignsGroup I, n=50
pGroup III, n=30
Rbefore treatment
after treatment
before treatment
after treatment
systolic index - Rice
0,51±0,03
1,14±0,11
<0,050,56±0,02
0,86±0,08
>0,05diastolic index - Reid
0,32±0,02
0,40±0,02
>0,050,28±0,02
0,31±0,03
>0,05The time of maximal systolic blood supply to the body-alpha,
0,25±0,03
0,17±0,01
<0,050,25±0,03
0,20±0,03
>0,05Amplitude ratio
1,86±0,15
2,16±0,22
>0,051,86±0,15
1,94±0,25
>0,05Duration of diastolic wave - TD with
0,59±0,03
0,20±0,02
<0,050,61±0,03
0,32±0,02
<0,05The indicator of the speed of pulse - SRP,%
20,01±2,10
26,16±1,58
>0,0521,12±2,11
(LK 23 : 43±1,76
>0,05Resistance, Ohm
51,42±5,30
38,75±2,12
<0,0550,23 ħ 4.83
48,12±2,46
>0,05The method of treatment of patients with dysfunction of the gallbladder, which consists in that the intake of bile hofitol drug and diet spend magnetotherapy, characterized in that the additional immediately after the procedure magnetotherapy affect pulsed electric current with neural impulse shapes, and the impact of the magnetic field carried out on the area of the neck area and liver, low-frequency alternating magnetic field of sine-shaped form, using rectangular inductors, continuous mode, frequency of 50 Hz magnetic induction (I-II levels of intensity for 10-15 minutes; multi-channel influence of pulsed electric shock with neural impulse shapes carry out at the level of the Th-VII-Th XI , paravertebral right, skin projection in the liver and gall bladder cross, using the 3 therapeutic channel, electrodes are set in 6 treatment fields: 1 - paravertebral right, at the level of the VII Th vertebra, 2 - paravertebral right, at the level of the XI Th vertebra, 3 - in the liver projection on the front surface of the trunk, 4 - in the liver projection on the back surface of the trunk, 5 - in projection of a gall bladder on the front surface of the trunk, 6 - in projection of a gall bubble on the back surface the torso, and 1 and 2 electrodes connected to IV channel, 3 and 4 electrodes - to a channel I, 5 and 6 to the second channel, friendly way in the channel, mixed, i.e. I, II channels operate in batch mode with frequency drift, and IV channel - continuous mode, fixed frequency, frequency of 20 Hz, the period of migration of current through the channels - 8, current - to the feeling expressed vibration under the electrodes, the duration of electrostimulation 10-15 minutes; course of treatment is 10-12 procedures, daily 1 procedure.