Method for specifying directionality of pathological process in mucinous gastric carcinoma |
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IPC classes for russian patent Method for specifying directionality of pathological process in mucinous gastric carcinoma (RU 2480771):
Method for prediction of recurrent endometrial polyps in postmenopausal women / 2478959
Transvaginal echography in the patients suffering endometrial polyps is conducted to measure an M-echo thickness, mm, the presence of obesity (Ob), blood follicle-stimulating hormone (FSH), IU/l, oestradiol (E2), pg/l; an insulin-resistance index is calculated by HOMA technique; a therapeutic strategy (ThStra) is taken into consideration; a probability of developing recurrent endometrial polyps (p) 1 year after the operation is determined by formula. If the probability exceeds 0.7, a high risk of recurrence is predicted. The probability falling within the range of 0.5 to 0.7 shows a moderate risk, while the probability of 0 to 0.5 shows a low risk.
Diagnostic technique for extraintestinal manifestations of celiac disease / 2476892
Blood serum is examined for prolactin and folic acid, and if the prolactin level is 30.6 ng/ml and more, while the folic acid level is 8.7 ng/ml and lower, the extraintestinal manifestations of celiac disease are diagnosed.
 Method for steroid profiling in dope test of sportsmen / 2467331
Invention refers to medicine, namely sports medicine, and may be used for steroid profiling in dope test of sportsmen. That is ensured by urine sample hydrolysis by a mixture of two enzymes: β-glucuronidase E.coli and arylsulphatase H.pomatia in volume ratio 1:1 to 1:3 in the presence of a citrated buffer solution and an internal standard. The hydrolysate is separated, derivatised that is followed by chromatic/mass-spectral analysis of the sample and recording of the derived results and stating the presence of endogenic steroids (ES). The ES value is determined in a sportsman for at least 10-15 times every 10-12 days. The analysis results are used to set minimum and maximum values of each of the derived ES. Said values are accepted to be a confidence range, and a steroid profile of the sportsman is drawn as a set of confidence ranges of all found ES.
Method of determining clinical effectiveness in cervical cancer / 2464576
One week after the termination of polychemotherapy, daily urine is examined for the amount of cortisol and cortisone, while blood is examined for adrenocorticotropic hormone. It is followed by calculating the relation of total cortisol and cortisone to adrenocorticotropic hormone. If the derived value is 0.74 and higher, high responsiveness to chemopreparations is stated.
Method for describing nature of arrested sexual development in boys in puberty with growth retardation / 2462720
Examination results are used to detect boys with the absence or insufficiency of blood concentrations of at least two of three hormones (luteinising hormone, follicle-stimulating hormone, total testosterone) to be used for the clinical course of transcranial magnetic therapy. The concentration of all hormones are evaluated in 1-1.5 months, and if observing increase of the concentrations of at least two hormones, including testosterone by min. 25% from the initial values, a functional nature of arrested sexual development is stated. If observing no increase or increase of the concentrations of two hormones, including testosterone by max. 25% from the initial values, an organic nature of arrested sexual development is stated.
 Diagnostic technique for idiopathic nasal breathing irregularities in pregnant women / 2456604
Blood serum of a pregnant woman is examined for the oestradiol concentration by enzyme-linked immunosorbent assay. Observing the oestradiol concentrations exceeding normal values according to weeks of gestation in 1.4 times and more enables stating idiopathic nasal breathing irregularities accompanying a period of pregnancy.
Method for prediction of level of efficiency of reduction of manifestation severity of atopic dermatitis / 2453851
Pre-therapy blood plasma is analysed for immunoglobulin E, adrenocorticotrophin and endorphin, the index SCORAD dynamics is determined by formula: Dsk=1.34147-0.000820741*IgE-0.00382642*ACTP+0.0209401*endorphin wherein IgE is the level of acute blood plasma immunoglobulin E mIU/ml; ACTP is the level of acute blood plasma adrenocorticotrophin ng/l. If observing the Dsk value exceeding 1.18, a prognosis of improving clinical dynamics of recovery is favourable; the conventional therapy is considered to be sufficient. The Dsk value being equal to 1.18 or less, the improving clinical dynamics of recovery is unfavourable, the intensified therapeutic scheme for atopic dermatitis is considered to be preferential.
 Method for identification and classification of 3-oxosteroids and their metabolites in doping test of sportsmen / 2452967
Blood plasma is examined for the presence and the position of double bonds and the related differences in structural characteristics. Common and examined steroids are chemically modified by a carboxyl group (oximes); their mass spectra are read out and recorded; characteristic ions (lc) and neutral loss (Do) are specified in the mass spectra. The specified lc and Do values are related to those specific for common 3-oxosteroid oximes by the absolute value. Herewith it is only the similar lc and Do values from both sides differing by 0.3% and less that are taken into consideration; the comparison results are used to identify 3-oxosteroid oximes.
Method of antenatal prediction of consequences of perinatal lesions of nervous system in children / 2449287
Clinical examination of pregnant woman is carried out, additionally performed are Stange's and Hench's functional respiratory tests in early period at terms of 11-19, 21-29, 31-39 weeks of gestation period, also in dynamics in I and III trimesters determined are indices of blood hormonal spectrum: T4, TSH, T3, cortisole, vitamin E, insulin, indices of lipid peroxidation and antioxidative blood activity, blood indices - hemoglobin, platelets, total protein, fibrinogen. Analysis of risk factors is carried out, their gradations and numerical values are determined and prognostic coefficients S1 and S2 are calculated by formulas. If S1>S2, presence of moderate or severe CNS lesion in children at the age of 4 is predicted. If S1<S2, presence of light degree of severity, or absence of consequences of CNS lesion in children at the age of 4 is predicted.
Method for prediction of dysthyroidism / 2446401
Method involves woman's pre-delivery blood serum examination for nitrogen oxide and relaxin that is followed by calculation of the NO/relaxin relation. If the relation is 3.6 and less, dysthyroidism is predicted.
Method for differential diagnostics of mammary diseases in men / 2244308
The present innovation deals with biochemical trials: before the onset of therapy in men one should detect blood content of thyroid hormone - free thyroxine - and at its level being 10.3-12.9 pmol/l one should diagnose mammary cancer, at the level of free throxine being 18.7-31.0 pmol/l - one should predict gynecomastia. The method enables to detect the direction of pathological process and carry out due correction of therapy tactics in men with either gynecomastia or mammary cancer.
Method for predicting the delay of intrauterine fetal development / 2246733
The method deals with studying blood serum of pregnant woman to detect the content of insulin-like growth factor (IGF) and vascular-endothelial growth factor (VEGF) and calculate the coefficient of their ratio: at its value being equal to 28.5 and lower it is possible to diagnose the delay of fetal development.
Method for differential diagnostic of chronic hepatitis and hepatic cirrhosis / 2254577
Thyroglobulin content is determined in blood serum using enzyme immunoassay. When thyroglobulin level is increased by 2 times and more compared in contrast with normal one chronic hepatitis is diagnosed, and when thyroglobulin level is decreased by 1.5-2.5 times in contrast with normal one hepatic cirrhosis is diagnosed.
Method for evaluating combined schizophrenia treatment based on atypical antipsychotic drugs and rations and electroconvulsive shock therapy / 2256181
Method involves determining dehydroepiandrosterone sulfate concentration in blood serum. Its growth above 30% when compared to the initial one being observed, treatment efficiency is determined as negative.
Method for diagnosing obliterated forms of congenital suprarenal gland cortex hyperplasia / 2261447
Method involves applying high effectiveness liquid chromatography for determining cortisol, cortisone 11-deoxycorticosterone, 11-deoxycortisone concentration in blood and free cortisol and free cortisone excretion with urine. Ratios of F/E and FF/FE are calculated, where F is the cortisol level in blood; E is the cortisone level in blood; FF is the free cortisol excretion with urine and FE is the free cortisone excretion with urine. The cortisol level in blood not exceeding norm and at least two of three signs: F/E ratio reduction by 25% and more, FF/FE ratio reduction by 25% and more, free cortisol excretion with urine being equal to 25% and more, obliterated forms of congenital suprarenal gland cortex hyperplasia is diagnosed. Corticosterone level in blood growing by 50% and higher, 21-hydroxylase defect is considered to be the case. 11-deoxycorticosterone and/or 11-deoxycortisone concentration in blood being et or greater than 50%, 11β-hydroxylase defect is considered to be the case.
 Method for diagnosing atrophic gastritis cases / 2262706
Method involves making pepsinogen 1, gastrin and Helicopter pylori infection marker combinations analysis and making input of the obtained results into data processing means comprising operation system, means for receiving, transmitting and processing data. The mentioned data processing means is usable for comparing the measured concentration value of a substance under study to a threshold value associated to the substance under study and producing information as a response to comparison results and additionally to other entered data. A set and software are used for implementing the method.
Method for predicting relapse of mammary cancer / 2263319
In the course of surveying in menopausal women after complex therapy one should state the development of mammary cancer at decreased ratio of estriol concentration to the sum of estrone and estradiol urinary concentrations from 1.68±0.23 in relapse-free patients up to 0.74±0.12 - in patients living without relapses for less than a year, up to 0.65±0.13 in patients living without relapse from 2 up to 6 years and up to 0.50±0.10 in patients with relapse-free period from 6 to 10 years. The innovation provides pre-clinical detection of mammary cancer relapse.
Method for predicting fetoplacental insufficiency in pregnant women with thyroid diseases / 2263919
Except detecting placental lactogen in blood serum one should study the content of alphafetoprotein. At placental lactogen content being below 75% against the norm and content of alphafetoprotein below 70% against the norm it is possible to conclude upon availability of fetoplacental insufficiency.
Method for predicting cholecystitis and cholelithiasis / 2263920
While diagnosing cholecystitis and cholelithiasis due to ultrasound testing one should additionally study blood plasma and bile to detect there the content of prostaglandins PGE2 and PGF2α. At PGE2/PGF2α ratio in blood plasma being equal to 6 and more, and, also, at decreased level of biliary cholecystokinin-pancreosimin by 38% and more, biliary PGE2 by 59% and more and increased level of biliary prostaglandin PGF2α by 5.9 times and more against the norm one should diagnose chlecystitis and cholelithiasis. The innovation enables to detect the above-mentioned diseases at earlier stage.
Method for predicting powerless labor in pregnant nodular goiter surgically treated on goiter occasion during pregnancy under medical supervision / 2273456
Method involves determining thyroid gland node diameter and thyrotropic hormone by applying ultrasonic examination approach. Histological examination is carried out with conclusion concerning morphologic nature being obtained like nodular colloid proliferating goiter or thyroid gland adenoma. Diagnostic index Σ is calculated from formula Σ=0.49*K1+0.07*K2-0.5*K3+1.76*K4-1.53, where K1 is the thyroid gland node diameter; K2 is the TTH concentration; K3 is the nodular colloid proliferating goiter index equal to 1 or 0; K4 is the thyroid gland adenoma index equal to 1 or 0. Diagnostic index Σ being less than zero, conclusions concerning powerless labor threat is to be drawn.
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FIELD: medicine. SUBSTANCE: in males with mucinous gastric carcinoma after a curative resection to the extent of gastrectomy, tumor tissue is analysed for the level of testosterone. If the tissue value is 7.8±0.6 ng/g, process generalisation within 6 to 12 months is predicted; the level of tissue testosterone 174.5±15.6 ng/g enables predicting the favourable clinical course of the process, prolongation of the patient's life. EFFECT: method allows the objective assessment of the pathological process directionality, the well-timed prediction of developing generalisation and taking adequate therapeutic measures. 2 ex
The invention relates to medicine, namely to Oncology, and can be used for timely assessment of the direction of development of the pathological process of the stomach and the appointment of adequate treatment. Known "Method of predicting the course of cancer" (Patent RF №2018835, bull. No. 16 from 30.08.94). The essence of the method lies in the fact that from the peripheral blood of cancer patients produce lymphocytes and neutrophils, determine the level of histamine in the next 4-5 days, I hope the attitude indicator in the lymphocytes to the level of amine in neutrophils, and values greater than 0.9 to predict an unfavorable course of the disease in the appearance of recurrence and metastases. However, the disadvantage of this method can be considered, on the one hand, the fact that the level of histamine in the blood may increase if the number of allergic diseases and intake of certain medications, but it is not possible to consider the analyzed indicator pathogenetically determined and used to forecast the development of the malignant process in the stomach, on the other hand the duration of the analysis associated with the separation of blood corpuscles and the definition and content of histamine within 4-5 days. As a prototype we have chosen "a method for predicting the development of metastases in patients with cancer who m the rectum" (Patent No. 2420742, bull. No. 16 dated 10.06.2011). The authors suggest, based on the determination of hormones testosterone and prolactin levels in tumor tissue and perifocal zone to predict the development of metastases in different terms. This method has an important prognostic value for patients with rectal cancer and is not used for gastric cancer. Also, despite the fact that the production of steroids, including local, connected with the floor, in this way, this point was not taken into account. The aim of the invention is the prediction direction for the development of malignant process in men, patients prestavitelyami gastric cancer. This goal is achieved by the fact that men in the tissue of malignant tumors of the stomach prestavitelyami of histotype after radical surgery in volume gastrectomy determine the level of testosterone, and when the values of 7.8±0.6 ng/g tissue predict the generalization process in a period of 6 to 12 months. High testosterone levels in tumor tissue (of 174.5±15,6 ng/g tissue) shows a favorable course of the process, as evidenced by the increasing life expectancy of patients. The invention "method for determining the orientation of the pathological process prestavitelyami stomach cancer" is new, because it is unknown from the level of edicine in forecasting development opportunities generalization of the malignant process. The novelty of the invention lies in the fact that in tumor tissue to determine the level of testosterone and at low concentrations predict the probability of the generalization process. This method of forecasting is new and gives the opportunity to take timely measures to prevent the development of distant metastasis of a tumor. In open sources information of Russia, CIS and abroad indications for a similar method for predicting the development of generalization prestavitelyami stomach cancer we have not identified. The invention is industrially applicable as it can be reproduced and repeated many times in the medical health care institutions. The method is as follows. A portion of the tumor tissue of the stomach in the amount of 100 mg crushed in homogenisator with 1 ml of cold sterile saline. The obtained homogenate was centrifuged for 30 min at 18000 rpm Precipitate was discarded, and the supernatant was determined by the level of testosterone by an enzyme immunoassay using sets of "Hema" (Russia). Determination of testosterone is based on the competitive enzyme immunoassay. Testosterone from a sample competes with the conjugated testosterone for binding to monoclonal antibodies on the surface of the well, forming a "sandwich", the soda is containing peroxidase. The concentration of testosterone is directly proportional to the associated activity, determined by interpolation on the calibration curve. An example of the application method can serve as a statement of case histories. Patient K., born in 1968, case history No.-16672/s, was admitted to the Department of General Oncology, RNII 12.11.2009, During the year there were pains in the epigastrium, by the end of August 2009 - nausea and occasional vomiting, lost 20 kg In October when FGDS revealed infiltrative cancer of the stomach, histological analysis No. 69043-46-persinality cancer. Ultrasound organs - increase in retroperitoneal lymph nodes epigastria to 1.5 see a Patient hospitalized in the Department to perform gastrectomy followed by chemotherapy. At laparotomy revealed a total infiltrative tumor of the stomach, spread the visceral and parietal peritoneum to 0.3 see During the surgery, the patient was taken tissue samples from the tumor. From tissue samples were prepared 10% homogenates was determined by the level of testosterone by an enzyme immunoassay using sets of "Hema" (Russia). Testosterone levels in tumor tissue amounted to 7.2 ng/g of tissue. The postoperative period was uneventful, with no complications. The level of leukocytes, peripheral blood lymphocytes was reduced; abnormalities in the biochemical analysis of blood, the total is m the urine sample was not. Sutures were removed on the 14th day. The patient was discharged in satisfactory condition with a diagnosis of stomach Cancer T3N1M1, St. IV, CL gr. II, countermats the visceral and parietal peritoneum. HA No. 72652-657/09 - persinality cancer invasion all layers of the stomach wall, MTS l/m/seal. At the place of residence had received treatment with Ftorafur per os. 6 months after surgery died in the generalization process, relapse in the anastomosis, dysphagia. Patient K., 1930 birth, history of disease-8180/s, was admitted to the Department of General Oncology, RNII 09.06.2009, Within months it had recurrent pain in the epigastrium, nausea, belching, vomiting, weakness. When FGDS revealed infiltrative tumor of the stomach, subcompensated stenosis of the output Department. Ultrasound of the abdominal cavity data for distant metastases no. The patient was hospitalized in the Department to perform gastrectomy. At laparotomy revealed infiltrative-ulcerous tumor output section of the stomach with subcompensated stenosis with the transition to the body of the stomach with metastases in lymph nodes in the projection of the left gastric vessels and greater omentum, with a diameter from 0.5 cm to 1.5 cm Distant metastases not detected. Was performed surgery in the volume gastrectomy, during which the sample was collected tumor tissue. A 10% homogenate of the tissue tumors ODA is delali testosterone by an enzyme immunoassay using a set of reagents firm "Hema" (Russia). The level of steroid in the tumor tissue was 185,4 ng/g of tissue. At discharge, the patient has the final diagnosis: gastric Cancer T3N1M0, St. III, class gr. II, HA No. 38199 - 202/09 - persinality c-r with a diffuse infiltrative growth, invasion all layers of the stomach wall, MTS m/omentum. The postoperative period was uneventful, with no complications. The level of leukocytes, peripheral blood lymphocytes was reduced; abnormalities in the biochemical blood analysis, urinalysis was not. Sutures were removed on the 12th day. The patient was discharged in satisfactory condition. Up to the present time is the observation of no evidence of disease progression (recurrence and distant metastases are absent). Were studied 15 men sick prestavitelyami gastric cancer T2-3 N0-2 M0-1, were treated in the Department of General Oncology, RNII and subjected to the operation. It is shown that 10 patients from 15 value content of testosterone in tumor tissue was varied in the range of 7.8±0.6 ng/g tissue compared. Found testosterone levels in tumor tissue was accompanied by the development of these patients have metastases in distant organs during the year (6 to 12 months). The remaining 5 patients, the level of steroid in the tumor tissue averaged 174,9±12,5 ng/g tissue. These patients are still alive within lat. Technical and economic efficiency of the method lies in the possibility of objective assessment of the direction of development of pathological process; timely forecasting of development of generalization; the adoption of adequate remedial measures. The method of determining the orientation of the pathological process prestavitelyami stomach cancer, including surgery, biochemical study, characterized in that in men with prestavitelyami gastric cancer after radical surgery in volume gastroektomii in tissue malignant tumor determine the level of testosterone and when the values of 7.8±0.6 ng/g tissue predict the generalization process in a period of 6 to 12 months, when the testosterone level of 174.5±15,6 ng/g tissue predicts favorable throughout the process, the increase of life expectancy of patients.
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