Method of bone resorption to remodelling analysis |
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IPC classes for russian patent Method of bone resorption to remodelling analysis (RU 2403870):
  
Method for assessment of kidney function in felines by measurement of ghrelin hormone levels / 2403573
Method for assessment of kidney function in felines includes determination of observed level of ghrelin in tissue or biofluid of feline and establishment of direct dependence of observed level of ghrelin on kidney function by comparison of observed level of ghrelin with reference level of ghrelin that characterises normal kidney function. Method for diagnostics of kidney disease in felines includes detection of observed level of ghrelin in tissue or biofluid of feline and comparison of observed ghrelin level with referent level of ghrelin, which characterises normal kidney function, where observed level lower than reference level indicates kidney disease or predisposition to it. Method for detection of kidney disease beginning in felines includes monitoring level of ghrelin in tissue or biofluid of feline for a certain period of time; where beginning is identified, if at any moment of time level of ghrelin decreases compared to initial level that characterises healthy kidney function. Diagnostics set includes (a) one or more test materials to detect observed levels of ghrelin in tissue or biofluid of feline; and (b) one or more user-available mediums bearing the following information: (i) reference level of ghrelin that corresponds to a specific feline; and (ii) algorithm of direct dependence of observed ghrelin level relative to reference level on kidney function or reverse dependence of observed ghrelin level relative to reference level on availability of kidney disease or predisposition to kidney disease.
Diagnostic technique for foetal maturity / 2399058
There are determined daily excretion of progesterone metabolite - pregnandiol (Pd), foetal steroids - 16α-hydroxy-ethiocholanolone (16α-OH-Et), 16α-hydroxy-androsterone (16α-OH-An), 16α-hydroxy-dihydroepiandrosterone (16α-OH-DHEA) and oestradiol (Oe) in pregnant women on their 37-42 weeks of pregnancy by capillary gas chromatography. A mature foetus is indicated by the following indices: daily Pd excretion is 150.4-348.3 mcmol/24 hour, 16α-OH-Et - 7.9-16.9 mcmol/24 hour, 16α-OH-An - 6.4-12.6 mkmol/24 hour, 16α-OH-DHEA - 15.4-26.1 mcmol/24 hour, Oe - 24.0-38.7 mcmol/24 hour, while an immature foetus show the indices as follows: daily Pd excretion 80.1-150.2 mcmol/24 hour, 16α-OH-Et - 5.8-7.8 mcmol/24 hour, 16α-OH-An - 4.6-6.3 mcmol/24 hour, 16α-OH-DHEA - 10.2-15.3 mcmol/24 hour, and Oe - 14.5-15.6 mcmol/24 hour, and in a overmature foetus, daily Pd excretion, 16α-OH-Et, 16α-OH-An, 16α-OH-DHEA and Oe are considerably lowered and are less than 50.0 mcmol/24 hour, less than 12.0 mcmol/24 hour, less than 5.8 mcmol/24 hour, less than 4.6 mcmol/24 hour, less than 10.2 mcmol/24 hour, respectively.
Method for prediction of clinical course in disseminated skin melanoma patients / 2399057
Method is implemented by blood analysis for total and free triiodothyronine after the termination of integrated treatment to derive the total to free triiodothyronine ratio, and it is within the range 0.26-0.31, steady state is predicted to be kept in the patients; the ratio within the range 0.19-0.22 ensures to predict the disease generalisation. Technical and economic efficiency of the invention consists in the fact that the derived prognosis factor is an informative laboratory covariant of the favourable or unfavourable development of the pathology.
Method for prediction of effectiveness of neoadjuvant automyelochemotherapy in patients with recurrent breast cancer / 2393484
Prior to begin the therapy, the patient's blood is tested for oestradiol concentration. If the concentration is 18.40 to 29.40 nmol/l, tumour size loss after the neoadjuvant automyelochemotherapy by 67-70% is predicted, that is a partial regress of the tumour, while oestradiol concentration 208.50 to 1541.0 nmol/l enables to predict the tumour size loss by 5-45% that is process stabilisation.
Method for determination severity level of trophological insufficiency in patients with chronic obstructive pulmonary disease / 2390026
Body weight index (BWI) is evaluated; if it is lower than 20 kg/m2, additional analysis is needed to determine the serum leptin concentration. If it is within 16.01±0.64 to 10.15±0.91 ng/ml, the absence of trophological insufficiency is diagnosed, while the values within 5.49±0.46 to 2.26 ng/ml enable to diagnose trophological insufficiency of medium severity, while the values 1.90 to 0.72±0.09 ng/ml indicate severe trophological insufficiency.
Method of forecasting retrocessions of larynx cancer / 2389030
In patients suffering from larynx cancer after surgical oncotomy in the course of dispensary observation levels of androsteron and estradiol in 24-hour collection urine are examined and their ratio to each other are determined. At ratio level more than 3 emergence of disease retrocession or metastasis in the near future is forecasted. At ratio level lower than 3 a long-lasting recurrence-free period is forecasted.
 Diagnostic technique for desynchronosis of hypophysial thyroid system in patients with severe bronchial asthma, previously not taking glucocorticoid therapy / 2382366
Diagnostic technique for desynchronosis of hypophysial thyroid system in the patients with severe bronchial asthma refers to medicine. Substance consists that blood of the patients is radioimmunoassayed for concentration of TSH, T3, T4 hormones. The obtained data are processed to draw a graphic curve of circadian rhythm for each hormone that provides a basis to determine individual acrophase and batiphase time. The acrophase (confidence interval) TSH development biorhythm 9 h 11 min (confidential interval 4 h 57 min to 13 h 26 min), T3 hormone - 15 h 01 min (confidential interval 8 h 05 min to 21 h 57 min) T4 hormone - 16 h 34 min (confidential interval 8 h 55 min to 24 h 13 min), and batiphase of circadian TSH secretion rhythm 21 h to 22 h, T3 - 2 h to 4 h, T4 4 h to 5 h ensure to diagnose apparent desynchronosis of hypophysial thyroid system.
Method for predicting depressive behaviour in aged primate, rates of aging and development of stress-dependent pathological changes / 2377570
Invention refers to medicine and veterinary science and can be used for predicting depressive behaviour of an aged primate, rates of ageing and development of stress-dependent pathological changes. According to the claimed invention, an aged primate is examined for psychoemotional reaction on soft and acute psychoemotional stress effect, molar concentration ratio of cortisol and dehydroepiandrosterone sulphate in peripheral blood plasma and percentage concentration of cortisol in peripheral blood plasma in the evening (20 o'clock 45 minutes - 21 o'clock 15 minutes) to concentration of cortisol in peripheral blood plasma in the morning (8 o'clock 45 minutes - 9 o'clock 15 minutes) to predict depressive behaviour in the aged primate with accelerated rates of ageing and development of stress-dependent pathological changes in depressive reaction on soft and acute psychoemotional stress effect, if molar concentration ratio of cortisol and dehydroepiandrosterone sulphate in peripheral blood plasma is not less than 4.3, and concentration of cortisol in peripheral blood plasma in the evening to concentration of cortisol in peripheral blood plasma in the morning is not less than 66%.
Method of estimating efficiency of neoadjuvant autohemochemotherapy in patients suffering from carcinoma of cervival stump / 2375063
Invention concerns medicine, namely oncology and can be used in estimation of clinical effectiveness factors in treatment of carcinoma of cervical stump. Daily urine is analysed for estradiol content and if decreased after treatment from initial level within 8.44-12.85 nmol/days, positive antineoplastic effect of treatment is stated, and if urine estradiol content is maintained in the treated patients within 8.81-11.38 nmol/days, the absence of antineoplastic effect is stated. The obtained results allow considering dynamics of estradiol content in daily urine of the patients suffering from carcinoma of cervical stump prior to AHCT as an additional laboratory test to estimate efficiency of presented pharmacotherapy. Observed positive clinical effect is confirmed by higher operability and improved life quality of the patients.
Method of determining effeciency of larynx cancer treatment / 2375003
Invention relates to medicine, namely to oncology and can be applied in presence of locally advanced process. In daily urine of patients before treatment tetrahydro-11-desoxycortisol is determined. If its level before treatment does not exceed 2 mcmol/day relapse-free period is forecasted during 2 and more years; initial level of fraction over 2 mcmol/day indicates about disease relapse or metastases during first year after treatment.
Method of detection of specific liver disease in leprosy patients / 2403869
Invention refers to medicine, namely to leprology, and can be used particularly for the detection of specific liver disease in the leprosy patients. Blood serum of the leprosy patients is analysed to determine the level of US-M.leprae and DIS-BSA leprosy mycobacteria antigen antibodies, and also the concentration of alpha-1-antitrypsin. If observing the level of antibodies to two antigens increased as compared to a norm and the concentration of alpha-1-antitrypsin increased higher than 346.7 mg/dl, liver disease is detected in the leprosy patients.
Method of risk evaluation of metabolic syndrome in patients with chronic cholecystitis / 2403868
Invention refers to medicine, namely to gastroenterology and cardiology, can be used in medical institutions for determination of severity level of metabolic disorders and risk of metabolic syndrome in the patients suffering chronic cholecystitis. For risk evaluation of metabolic syndrome in the patients with chronic cholecystitis by the severity of immune-metabolic disorders, the following significant diagnostic characters are used: fasting glucose, apoprotein atherogenicity coefficient (apoB/anoAl), high density lipoprotein cholesterol, T-helpers and T-suppressors ratio, phagocytic index. The derived values are entered in an arithmetic formula to evaluate the risk of metabolic syndrome by the severity level of immune-metabolic disorders by total value expressed in standard units.
Preoperative differential diagnostic technique of peripheral nerve tumours / 2403862
Invention refers to medicine, namely to neurosurgery. It involves clinico-neurological examination to be carried on. A degree of nerve conduction abnormality is determined. Neurofibroma is diagnosed by the presence of pain symptom, a palpated space-occupying lesion and the absence or functionally insignificant decrease in nerve trunk conductivity. Neurinoma is diagnosed by the presence of pain symptom, a palpated space-occupying lesion and the evident functionally significant abnormalities of nerve trunk conductivity.
Method for prediction of cerebral metastases of pulmonary cancer / 2402280
Invention refers to medicine, namely to oncology and can be used for prediction of cerebral metastases of pulmonary cancer The method involves the determination of prognostic indices by clinical anamnestic data If observing such prognostic indices as 55-60-year-old age in males, diagnosed peripheral adenocarcinoma or small cell carcinoma of right lung, T2-T3N2 (IIIA) stage, non-administered adjuvant therapy, the occurrence of cerebral metastases, mainly in the left brain is predicted within approximately 10 months after a primary tumour has been detected.
Method for prediction of myopia transition to progressive form / 2402279
Invention refers to medicine, particularly to ophthalmology, can be used for prediction of progression of myopia acquired in schools in 10-14 and 15-17 year old children. Blood serum is analysed for cartilage glycoprotein-39 with the use of sandwich-type enzyme immunoassay. If its concentration is within 34.7-53.4 ng/ml in 10-14-year-old children and 22-56.3 ng/ml in 15-17-year-old children, a permanent course of myopia is predicted. The concentration 18.5-33.9 ng/ml in 10-14-year-old children and 53.7-69 ng/ml in 15-17-year-old children enables to predict a progressive course of myopia.
Method of noninvasive evaluation of histology activity index in patients with chronic viral hepatitis / 2402278
Method relates to medicine, hepatology. In a patient with chronic viral hepatitis, abdominal ultrasound is applied. The following diagnostic criteria are observed: thickness of left lobe of liver; length of spleen, liver size, liver echogenicity, diametre of splenic vein; diametre of superior mesenteric vein, diametre of hepatic artery, mean blood velocity in portal vein. The histology activity index is calculated by an original mathematical formula.
 Method of optimising diagnosis of stages of acute disseminated intravascular coagulation / 2402277
Invention refers to medicine, namely to aggressive medical therapy, resuscitation science, critical care medicine, laboratory diagnostics and can be used by resuscitators, intensivists, laboratory doctors for well-timed diagnosis and consequently, for individualised aggressive medical therapy of acute disseminated intravascular coagulation. The integrated assessment of links of haemostatic system and the clinical appraisal of organ dysfunction are applied in a measurer, and when observing structural hypercoagulation characterised by fibrinogen level increase, thrombocyte activity increase, growth of soluble fibrin complex (SFC) level, and also when observing chronometric hypercoagulation characterised by time tests, palette-derived factor 4 activity (P4) with manifested petechial haemorrhage and organ dysfunction, and coagulation cascade activation with underlying depression of antithrombin III and protein C, a hypercoagulation stage of acute DIC is diagnosed. Chronometric hypercoagulation by Activated partial thromboplastin time (APTT), INR, fibrinogen and P4 with manifested signs of structural hypocoagulation by thrombin time prolongation and D-dimer activity increase with underlying further intensification of anticoagulant system deficiency, progression of target organs dysfunction and mixed haemorrhage show a transitive stage of acute DIC. If observing said hypocoagulation changes and disturbed fibrinolytic activity with prevailing either decompensated organ and tissue dysfunction, or hemorrhagic syndrome up to system haemorrhages, or their combination with hemorrhagic syndrome characterised by polymorphism of clinical picture and localisation: petechial-haematoma haemorrhage at the stress-induced stomach ulcers, hematuria, a coagulopathy stage of acute DIC is diagnosed that is characterised either by depression of fibrinolysis, or preserved fibrinolytic activity, or by activation of secondary fibrinolysis, or by acute primary fibrinolysis.
Diagnostic technique for respiratory function of erythrocyte in pregnant women by erythrocyte glutathione reductase activity test in aggravated herpes virus infection / 2402276
Invention refers to medicine, namely to diagnostic techniques and concerns a diagnostic techniques technique for respiratory function of peripheral blood erythrocytes in pregnant women in herpes virus infection episode in the third trimester. The technique consists in determination of glutathione reductase and herpes virus antibody titre concentration by the enzyme immunoassay in peripheral blood in pregnant women suffered from a herpes virus infection episode. If glutathione reductase concentration is 8.36±0.137 E/g Hb (ref. - 7.82±0.185 E/g Hb), herpes virus antibody titre is 1:6400. If herpes virus antibody titre is increased to 1:12800, erythrocyte glutathione reductase concentration is decreased 4.48±0.22 E/g Hb.
 Method of chewing system functioning evaluation / 2402275
Method of chewing system functioning evaluation refers to medicine, particularly to orthopaedic dentistry. A chewing test involves face bow recording in patients. A face bow index (FBI) is calculated by formula:
 Differential diagnostic technique for herpetic infections of gastric mucosa or dental pulp / 2401072
Differential diagnostics of herpetic infections of gastric mucosa us membranes of a stomach or dental pulp is ensured by coordination marking of a biopsy material. Histologic sections of thickness no more than 3 mcm are prepared. The prepared sections are applied on slides as follows: the first section is arranged on the first slide, the second section is applied on the second, the third slide is used for the third section, the fourth section is placed on the first slide and further the same sequence, the number of slides is determined by the identified virus count. Each preparation is analysed for specific viruses of the herpes groups by immunohistochemistry with using specific monoclonal antibodies. The results of each reaction are recorded by the presence of specifically stained antigen granules in a histologic sample, and the images of the results of each reaction are saved in the electronic form. The formed images of the following sections are aligned by the coordination mark. If observing the specifically stained antigen granules of various localisation, herpetic mixed infection of gastric mucosa and dental pulp is diagnosed. When observing the specifically stained antigen granules of the same localisation herpetic monoinfection with immune cross-reaction is diagnosed.
 Method for predicting the result of acute peroral intoxication with cauterizing liquids / 2244930
At patient's hospitalization one should gather the data of clinical and laboratory values: on the type of chemical substance, patient's age, data of clinical survey and laboratory values: body temperature, the presence or absence of dysphonia, oliguria being below 30 ml/h, hemoglobinuria, erythrocytic hemolysis, exotoxic shock, glucose level in blood, fibrinogen and creatinine concentration in blood serum, general bilirubin, prothrombin index (PTI), Ph-plasma, the state of blood clotting system. The state of every sign should be evaluated in points to be then summed up and at exceeding the sum of points being above "+20" one should predict unfavorable result. At the sum of "-13" prediction should be stated upon as favorable and at "-13" up to "+20" - prediction is considered to be doubtful.
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FIELD: medicine. SUBSTANCE: invention refers to medicine, namely to biochemistry, surgery and dentistry. The bone resorption to remodeling analysis is based on the biochemical blood examination. An the blood coefficient K1 is calculated by formula: K1=[(PTH:A)+(TNF-α:B)+(IL-1β:C)]:3, where PTH is the parathyroid hormone concentration (pg/ml) in the patients, A is the same value in healthy individuals, TNF-α is the level of tumor necrosis factor -α (pg/ml) in the patients, B is the same value in healthy individuals, IL-1β is the interleukin-1β concentration (pg/ml) in the patients, C is the same value in healthy individuals to derive the blood coefficient K2 by formula: K2=[(calcitonin: D) + (osteocalcin: E)]:2, where the calcitonin concentration (ng/ml) in the patients, D is the same value in healthy individuals, the osteocalcin level (ng/ml) in the patients, E is the same value in healthy individuals. Then the bone metabolism control coefficient (BMCC) is calculated by formula BMCC=K1:K2, and the higher BMCC than 1.17, the more intensive resorption prevails over remodelling; and the lower BMCC than 0.83, the more intensive remodelling prevails over resorption. EFFECT: method allows high accuracy detection of prevalence of resorption or remodelling intensity in the bone stock metabolism control in practically healthy individuals (monitoring) and in pathology cased for the purpose of diagnosis, assessment and therapeutic prognosis. 5 tbl, 3 dwg, 2 ex
The invention relates to the field of medicine, namely biochemistry, surgery and dentistry, can be used to determine the correlation between physiological resorption and remodeling in the regulation of metabolism of bone tissue in healthy individuals (control) and in pathology for the purpose of diagnosis, evaluation and treatment. There is a method of evaluation of the balance of bone formation and bone resorption on the display (in the form of two rectangles) content in bone peptidoglycan and protein-bound hydroxyproline (Systemic osteoporosis in the development of periodontal disease. /Vis, Npesr, Genvissa and other / / / Visnyk. - 1997. No. 4. - S-556). This method, shown in figure 1, was selected as the prototype. However, this method only allows us to Express the assumption of a possible change in the balance between biosynthesis and degradation of collagen on the basis of determination of the fractions peptidoglycan and protein-bound hydroxyproline, as the authors did not observe the scale: on the image in a generalized periodontitis, chronic course 1 degree above the 1.44 mg/l peptidoglycan hydroxyproline and 8,79 mg/l protein-bound hydroxyproline depicted by rectangles almost the same size, and the digital values are represented by only men and women who h they are missing. At 2 degrees and exacerbated chronic periodontitis digital values are missing in men and women. Thus, 10 units of 12 not confirmed mathematically. The objective of the invention is to increase the efficiency evaluation of the balance of resorption and remodeling of bone. The technical result is to increase the accuracy of the estimate of the ratio of resorption and remodeling of bone tissue. This is due to the fact that I expect the coefficient K1in the blood by the formula: K1=[(PTH:A) + (TNF-α:B) + (IL-1β:)]:3, where PTH is the content of parathormone (PG/ml) in patients And in healthy people, TNF-α - levels of tumor necrosis factor-α (PG/ml) in patients with B - healthy, IL-1β concentration of interleukin-1β (PG/ml) patients, in healthy people, then determine the factor K2in the blood by the formula: To2=[(calcitonin:G) + (osteocalcin:D)]:2, where the concentration of calcitonin (ng/ml) patients, in healthy people, the level of osteocalcin (ng/ml) patients, Dr. in healthy people, and then calculate the ratio of bone metabolism regulation (KROK) by the formula KROK=K1:2at higher KROK values of 1.17, the more prevalent the process of resorption over remodeling; and the lower the step the values of 0.83, the more prevalent remodeling over resorption. To identify what regulirovaniya processes of resorption and remodeling of bone were taken parathyroid hormone, the tumor necrosis factor-α, interleukin-1β, as they are common markers for assessment of bone resorption, and calcitonin, osteocalcin as markers of bone turnover. Is the CROC 1.17 and 0,83 obtained by mathematical calculations. As a highly credible evidence of the prevalence of resorption and remodeling, are not taken into account is the step of 0.83 to 1.17, as they are in the range of twice the average statistical error (±m), the average value (M) of variational series of n number of members. The dimensions of atrophy of the alveolar part of the jaw was studied on the basis of local dental status, including inspection, palpation, analysis plaster diagnostic models, data orthopantomography and computed tomography. The condition of the alveolar part of the jaw has been evaluated depending on the volume of bone, sufficient for dental implantation, following classification (table 1.) (Misch S.E., Judy K.W.M. Classification of partially edentulous arches for implant dentistry // Int. J. Oral Implant. 1987. - Vol.4. - P.7-12).
We investigated 62 people, including 10 healthy individuals of both sexes. As in most cases, atrophy of alveolar bone combined with thyroid cancer, 52 patients were divided into 2 groups. 22 patients of both sexes aged 35-50 with atrophy of the jaw bone categories and hyperthyroidism various etiologies formed the first group. II group consisted of 30 patients (20 women and 10 men) aged 30-50 years with hypofunction of the thyroid gland and atrophy of the jaw bone category b and C. The method is as follows: the patient performed a biochemical analysis of blood, detect the concentration of markers of bone and calculate the K-factor1in formula is: K 1=[(PTH:A) + (TNF-α:B) + (IL-1β:)]:3, where PTH is the content of parathormone (PG/ml) in patients And in healthy people, TNF-α - levels of tumor necrosis factor-α (PG/ml) in patients with B - healthy, IL-1β concentration of interleukin-1β (PG/ml) patients, in healthy people, then determine the factor K2according to the formula: To2=[(calcitonin:G) + (osteocalcin:D)]:2, where the concentration of calcitonin (ng/ml) patients, in healthy people, the level of osteocalcin (ng/ml) patients, Dr. in healthy people, and then calculate the ratio of bone metabolism regulation (KROK) by the formula KROK=K1:2at higher 1,17 is the CROC, the more prevalent the process of resorption over remodeling, and the lower 0.83 value of the CRIC, the more prevalent remodeling over resorption. Is the CROC of 0.83 to 1.17 is in the range of twice the average statistical error (±m) arithmetic mean value (M), and should not be considered as highly reliable evidence of the prevalence of resorption over bone remodeling. To assess and forecast the treatment method can be carried out repeatedly. Clinical example 1. Patient C., 48 years old, came in CDC University with complaints about the lack of teeth in the lower jaw. When clinical and radiological examination atrophy of the alveolar part of the lower h is lusty height less than 8 mm and width 5 mm (atrophy categories), she spent the biochemical analysis of blood revealed the concentration of markers of resorption and remodeling of bone tissue, was calculated (see table 2), the coefficient K1according to the formula: K1=[(PTH:A)+(TNF-α:B)+(IL-1β:)]:3=[(85,6:53,0)+(21,6:8,1)+(19,6:5,0)]:3=2,71, further identified factor K2according to the formula: K2=[(calcitonin:G) + (osteocalcin:D)]:2=[(1,6:3,0)+(8,3:13,0))]:2=0,58, then calculated the coefficient of metabolism regulation of bone CROC by the formula KROK=K1:2=2,71:0,58=4,67. The conclusion was made about the prevalence of the patient Century. the process of resorption over the remodeling of bone tissue. After treatment, the patient was re-conducted biochemical analysis of the blood revealed the concentration of markers of resorption and remodeling of bone tissue and calculated (see table 2) factor K1according to the formula: K1=[(PTH:A)+(TNF-α:B)+(IL-1β:)]:3=[(55,2:53,0)+(9,2:8,1)+(5,4:5,0)]:3=1,09, hereinafter defined coefficient K2according to the formula: K2=[(calcitonin:G) + (osteocalcin:D)]:2=[(2,9:3,0)+(12,8:13,0))]:2=0,97, then calculated the coefficient of metabolism regulation of bone CROC by the formula KROK=K1:2=1,09:0,97=1,12. The conclusion was made about the lack of after treatment, the prevalence of highly reliable process of remodeling of bone tissue over resorption, as is the CROC less 1,17. Clearly seen in table 2 and in the calculation of the odds that the patient C. the content of f is Ktorov resorption of bone tissue before treatment dramatically increased, and factors remodeling is significantly reduced, compared with the control. The treatment helped raise her blood remodeling factors and reduction factors of bone resorption.
Similar changes are listed in table 3 and figure 2 (figure 2 - factor KROK, calculated on the basis of the coefficients of K1and K2reflecting before and after comprehensive adjustment balance between factors that promote bone resorption (PTH, TNF-α, IL-1β) and osteogenesis (calcitonin, osteocalcin) in 22 patients of reproductive age with atrophy of alveolar bone categories With osteopenic syndrome with hyperactivity of the thyroid gland, with indicators of the 22 patients of group I.
To1before treatment: = PTH + TNF-α + IL-1β: 1,71+3,11+was 4.02=8,84. The average value of K1of the three definitions 8,84:3=2,97. To2before treatment. The sum of the two factors stimulate osteogenesis calcitonin and osteocalcin 0,56+0,55=1,02. The average K2two definitions of 1.02:2=0,51. KROK before treatment. The ratio of the two mean values of the factors stimulating resorption and remodeling of 2.97:0,51=of 5.82. K1after the treatment. The sum of three factors stimulate bone resorption PTH+TNF-α+IL-1β: 1,04+1,16+1,28=3,48. The average value of the three definitions of 3.48:3=1,16. To2after the treatment. The sum of the two factors of stimulation is of osteogenesis calcitonin and osteocalcin 0,93+0,92=1,95. The average value of the two definitions 1,95:2=0,97. KROK after treatment. The ratio of averages resorption and bone remodeling after treatment 1,16:0,97=1,19. It was concluded that increase of nearly 6 times the value of the CROC in this group of patients before treatment and the drop in the value KROK after treatment almost 5 times. However, after the fall there is a small prevalence of resorption over remodeling, which, apparently, may indicate a lack of full recovery. II group-30 women of reproductive age with hypofunction of the thyroid gland and atrophy of the jaw bone of the upper jaw categories b and C. Clinical example 2. Patient P., 49 years old, came in CDC University with complaints about the lack of teeth in the upper jaw on the left. After clinical and radiographic examination revealed atrophy of the alveolar ridge of the upper jaw height less than 5 mm (bone atrophy categories). Comparison of biochemical parameters resorption and remodeling of bone in the blood (M±m) patient N. with bone atrophy categories and hypothyroidism before and after treatment with the blood of healthy individuals without atrophy of the jaw bone, osteopenia and osteoporosis (control a, B, C, D, e). The blood counts of patients and healthy persons
K1before treatment. The sum of three factors stimulate bone resorption PTH+TNF-α+IL-1β: 1,24+1,37+1,24=3,85. The average value of the three definitions of 3.45:3=1,28. To2before treatment. The sum of the two factors stimulate osteogenesis calcitonin and osteocalcin: 0,70+0,41=1,17. The average value of K1of the two definitions 1,17:2=0,58. KROK before treatment. The ratio of mean values of factors resorption and stimulation of bone turnover before treatment 1,28:0,58=2,21. K1after the treatment. The sum of three factors stimulate bone resorption PTH+TNF-α+IL-1β: 0,98+0,96+1,00=2,94. The average value of the three parameters after treatment 2,94:3=0,98. To2after the treatment. The sum of the two factors stimulate osteogenesis, calcitonin and osteocalcin: 1,07+1,01=2,08. The average value of K1of the two definitions 2,08:2=1,04. KROK after treatment. The ratio of mean values of factors resorption and bone remodeling after treatment: 0,98:1,04=0,94. The same offense as the patient P., detected during the examination of all persons group II. Comparison of biochemical parameters resorption and remodeling of bone in the blood (M±m) after the correction of the imbalance remodeling in patients of reproductive age with hypothyroidism.
Figure 3 presents the ratio of the CRIC, calculated on the basis of the coefficients K1and K2reflecting before and after comprehensive adjustment balance between factors that promote bone resorption (PTH, TNF-α, IL-1β) and osteogenesis (Kahle is Ionin, osteocalcin), 30 women of reproductive age with atrophy of alveolar bone category b and C in osteopenic syndrome and hypothyroidism. Figure 3 shows more than doubled (compared with control) to increase the value KROK patients with atrophy of the alveolar ridge of the mandible, and then convincing the decrease in the value CROC to 0.94, which confirms the effectiveness of treatment. The method of evaluation of the balance of resorption and remodeling of bone on the basis of the evaluation of biochemical parameters of blood, characterized in that the calculated coefficient K1in the blood by the formula:
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