Method of forecasting retrocessions of larynx cancer |
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IPC classes for russian patent Method of forecasting retrocessions of larynx cancer (RU 2389030):
 Diagnostic technique for desynchronosis of hypophysial thyroid system in patients with severe bronchial asthma, previously not taking glucocorticoid therapy / 2382366
Diagnostic technique for desynchronosis of hypophysial thyroid system in the patients with severe bronchial asthma refers to medicine. Substance consists that blood of the patients is radioimmunoassayed for concentration of TSH, T3, T4 hormones. The obtained data are processed to draw a graphic curve of circadian rhythm for each hormone that provides a basis to determine individual acrophase and batiphase time. The acrophase (confidence interval) TSH development biorhythm 9 h 11 min (confidential interval 4 h 57 min to 13 h 26 min), T3 hormone - 15 h 01 min (confidential interval 8 h 05 min to 21 h 57 min) T4 hormone - 16 h 34 min (confidential interval 8 h 55 min to 24 h 13 min), and batiphase of circadian TSH secretion rhythm 21 h to 22 h, T3 - 2 h to 4 h, T4 4 h to 5 h ensure to diagnose apparent desynchronosis of hypophysial thyroid system.
Method for predicting depressive behaviour in aged primate, rates of aging and development of stress-dependent pathological changes / 2377570
Invention refers to medicine and veterinary science and can be used for predicting depressive behaviour of an aged primate, rates of ageing and development of stress-dependent pathological changes. According to the claimed invention, an aged primate is examined for psychoemotional reaction on soft and acute psychoemotional stress effect, molar concentration ratio of cortisol and dehydroepiandrosterone sulphate in peripheral blood plasma and percentage concentration of cortisol in peripheral blood plasma in the evening (20 o'clock 45 minutes - 21 o'clock 15 minutes) to concentration of cortisol in peripheral blood plasma in the morning (8 o'clock 45 minutes - 9 o'clock 15 minutes) to predict depressive behaviour in the aged primate with accelerated rates of ageing and development of stress-dependent pathological changes in depressive reaction on soft and acute psychoemotional stress effect, if molar concentration ratio of cortisol and dehydroepiandrosterone sulphate in peripheral blood plasma is not less than 4.3, and concentration of cortisol in peripheral blood plasma in the evening to concentration of cortisol in peripheral blood plasma in the morning is not less than 66%.
Method of estimating efficiency of neoadjuvant autohemochemotherapy in patients suffering from carcinoma of cervival stump / 2375063
Invention concerns medicine, namely oncology and can be used in estimation of clinical effectiveness factors in treatment of carcinoma of cervical stump. Daily urine is analysed for estradiol content and if decreased after treatment from initial level within 8.44-12.85 nmol/days, positive antineoplastic effect of treatment is stated, and if urine estradiol content is maintained in the treated patients within 8.81-11.38 nmol/days, the absence of antineoplastic effect is stated. The obtained results allow considering dynamics of estradiol content in daily urine of the patients suffering from carcinoma of cervical stump prior to AHCT as an additional laboratory test to estimate efficiency of presented pharmacotherapy. Observed positive clinical effect is confirmed by higher operability and improved life quality of the patients.
Method of determining effeciency of larynx cancer treatment / 2375003
Invention relates to medicine, namely to oncology and can be applied in presence of locally advanced process. In daily urine of patients before treatment tetrahydro-11-desoxycortisol is determined. If its level before treatment does not exceed 2 mcmol/day relapse-free period is forecasted during 2 and more years; initial level of fraction over 2 mcmol/day indicates about disease relapse or metastases during first year after treatment.
Way of forecasting of restoration of menstrual function at patients with nervous anorexia / 2363002
Invention concerns medicine, namely to gynecology, and can be used at treatment of patients with amenorrhea caused by nervous anorexia. Level of leptin is defined in blood serum using enzyme immunoassay method for realisation of the way of forecasting of restoration of menstrual function at patients with a nervous anorexia. Then an index of mass of a body (BMI) and a parity leptin/BMI is counted. In case the parity leptin/BMI makes 0.8 and more - normalisation of menstrual function is prognosticated.
Way of diagnostics of male sterility / 2362167
Invention concerns medicine area, namely to andrology, and concerns diagnostics of male sterility. The way includes studying compaction degree of chromatin of spermatozoids, percentage of defective cells in an ejaculate, level of B in blood serum. On the basis of the received data diagnostic index DI is calculated; its value helps to diagnose sterility, or absence of pathology.
 Method of diagnosing functional hyperprolactinaemia in girls / 2351935
In girls with suspected functional hyperprolactinaemia determined are level of prolactin two hours after falling asleep, concentration of general triiodtrionin, cortisol, and ultra-sound examination of small pelvis organs is carried out in order to determine volume of right ovary. On the basis of obtained data canonical value (K) is calculated by formula, and if K is greater than (-2.28) and lower than 1.27 functional hyperprolactinaemia is determined.
 Method of diagnosing hormonally inactive microadenomas of hypophysis in girls / 2351934
Invention can be used for diagnosing hormonally inactive microadenomas of hypophysis (IAH) in girls. In order to realise the method levels of prolactin in blood is determined in girls with suspected two hours after falling asleep and at 6 o'clock in the morning. On the basis of obtained data, canonical value (K) is calculated by formula, and if K is greater than (-1.69) and smaller than 1.86 IAH is diagnosed.
Method of determination of orientation of pathological process at cancer of ovaries / 2350966
Invention concerns medicine, namely to onco-gynecology. The essence of the method consists in the following: level of Testosteron is defined and at its content peer or above 2.5 nmol/l, intraoperative in blood of women with tumorous formations of ovaries before operation. In a tissue of a tumour of ovaries the maintenance of Testosteron is defined and at augmentation of its indicator above 2 nmol/g operation of full volume is carried out.
 Evaluation method for perioperative stress and quality of organism nociceptive protection / 2342669
Invention relates to medicine, namely surgery and anesthesiology, and refers to evaluation method for perioperative stress and quality of organism nociceptive protection. The method consists in radioimmunoassay of cortisol content in daily urine before and after the operation, beginning with first post-operative urine portion, and finishing with next day morning urine. If cortisol concentration has grown twice and higher, then inadequate organism protection from operative stress and post-operative pain syndrome is stated.
Method for differential diagnostics of mammary diseases in men / 2244308
The present innovation deals with biochemical trials: before the onset of therapy in men one should detect blood content of thyroid hormone - free thyroxine - and at its level being 10.3-12.9 pmol/l one should diagnose mammary cancer, at the level of free throxine being 18.7-31.0 pmol/l - one should predict gynecomastia. The method enables to detect the direction of pathological process and carry out due correction of therapy tactics in men with either gynecomastia or mammary cancer.
Method for predicting the delay of intrauterine fetal development / 2246733
The method deals with studying blood serum of pregnant woman to detect the content of insulin-like growth factor (IGF) and vascular-endothelial growth factor (VEGF) and calculate the coefficient of their ratio: at its value being equal to 28.5 and lower it is possible to diagnose the delay of fetal development.
Method for differential diagnostic of chronic hepatitis and hepatic cirrhosis / 2254577
Thyroglobulin content is determined in blood serum using enzyme immunoassay. When thyroglobulin level is increased by 2 times and more compared in contrast with normal one chronic hepatitis is diagnosed, and when thyroglobulin level is decreased by 1.5-2.5 times in contrast with normal one hepatic cirrhosis is diagnosed.
Method for evaluating combined schizophrenia treatment based on atypical antipsychotic drugs and rations and electroconvulsive shock therapy / 2256181
Method involves determining dehydroepiandrosterone sulfate concentration in blood serum. Its growth above 30% when compared to the initial one being observed, treatment efficiency is determined as negative.
Method for diagnosing obliterated forms of congenital suprarenal gland cortex hyperplasia / 2261447
Method involves applying high effectiveness liquid chromatography for determining cortisol, cortisone 11-deoxycorticosterone, 11-deoxycortisone concentration in blood and free cortisol and free cortisone excretion with urine. Ratios of F/E and FF/FE are calculated, where F is the cortisol level in blood; E is the cortisone level in blood; FF is the free cortisol excretion with urine and FE is the free cortisone excretion with urine. The cortisol level in blood not exceeding norm and at least two of three signs: F/E ratio reduction by 25% and more, FF/FE ratio reduction by 25% and more, free cortisol excretion with urine being equal to 25% and more, obliterated forms of congenital suprarenal gland cortex hyperplasia is diagnosed. Corticosterone level in blood growing by 50% and higher, 21-hydroxylase defect is considered to be the case. 11-deoxycorticosterone and/or 11-deoxycortisone concentration in blood being et or greater than 50%, 11β-hydroxylase defect is considered to be the case.
 Method for diagnosing atrophic gastritis cases / 2262706
Method involves making pepsinogen 1, gastrin and Helicopter pylori infection marker combinations analysis and making input of the obtained results into data processing means comprising operation system, means for receiving, transmitting and processing data. The mentioned data processing means is usable for comparing the measured concentration value of a substance under study to a threshold value associated to the substance under study and producing information as a response to comparison results and additionally to other entered data. A set and software are used for implementing the method.
Method for predicting relapse of mammary cancer / 2263319
In the course of surveying in menopausal women after complex therapy one should state the development of mammary cancer at decreased ratio of estriol concentration to the sum of estrone and estradiol urinary concentrations from 1.68±0.23 in relapse-free patients up to 0.74±0.12 - in patients living without relapses for less than a year, up to 0.65±0.13 in patients living without relapse from 2 up to 6 years and up to 0.50±0.10 in patients with relapse-free period from 6 to 10 years. The innovation provides pre-clinical detection of mammary cancer relapse.
Method for predicting fetoplacental insufficiency in pregnant women with thyroid diseases / 2263919
Except detecting placental lactogen in blood serum one should study the content of alphafetoprotein. At placental lactogen content being below 75% against the norm and content of alphafetoprotein below 70% against the norm it is possible to conclude upon availability of fetoplacental insufficiency.
Method for predicting cholecystitis and cholelithiasis / 2263920
While diagnosing cholecystitis and cholelithiasis due to ultrasound testing one should additionally study blood plasma and bile to detect there the content of prostaglandins PGE2 and PGF2α. At PGE2/PGF2α ratio in blood plasma being equal to 6 and more, and, also, at decreased level of biliary cholecystokinin-pancreosimin by 38% and more, biliary PGE2 by 59% and more and increased level of biliary prostaglandin PGF2α by 5.9 times and more against the norm one should diagnose chlecystitis and cholelithiasis. The innovation enables to detect the above-mentioned diseases at earlier stage.
Method for predicting powerless labor in pregnant nodular goiter surgically treated on goiter occasion during pregnancy under medical supervision / 2273456
Method involves determining thyroid gland node diameter and thyrotropic hormone by applying ultrasonic examination approach. Histological examination is carried out with conclusion concerning morphologic nature being obtained like nodular colloid proliferating goiter or thyroid gland adenoma. Diagnostic index Σ is calculated from formula Σ=0.49*K1+0.07*K2-0.5*K3+1.76*K4-1.53, where K1 is the thyroid gland node diameter; K2 is the TTH concentration; K3 is the nodular colloid proliferating goiter index equal to 1 or 0; K4 is the thyroid gland adenoma index equal to 1 or 0. Diagnostic index Σ being less than zero, conclusions concerning powerless labor threat is to be drawn.
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FIELD: medicine. SUBSTANCE: in patients suffering from larynx cancer after surgical oncotomy in the course of dispensary observation levels of androsteron and estradiol in 24-hour collection urine are examined and their ratio to each other are determined. At ratio level more than 3 emergence of disease retrocession or metastasis in the near future is forecasted. At ratio level lower than 3 a long-lasting recurrence-free period is forecasted. EFFECT: use of this method enables to forecast emergence of larynx cancer retrocession and to assume measures to individualise therapeutic modality. 2 ex
The invention relates to medicine, namely to Oncology, and can be used after conducting a combined treatment of cancer of the larynx. Larynx cancer is a tumor, the formation and development of which is associated with the influence of sex hormones androgenic and ekstrennogo series. While androgens stimulate the development of laryngeal cancer, and estrogen - brake. Known "Method of predicting the effectiveness of autohemotherapy cancer patients organs of the oral cavity and pharynx" - patent # 2253354, BI No. 16 dated 10.06.2005 year. The authors as a criterion of the effectiveness of anticancer therapy suggest using the dynamics of the ratio of the concentration of the thyroid hormone triiodothyronine and thyroxine and pituitary hormone - tireotropina. The proposed method allows to determine in advance the degree of effectiveness of anticancer therapy. However, what will be the course of the malignant process, the intensity of its development, when will manifest disease recurrence and for how long will relapse-free period, the known method does not provide answers. There is a method of predicting treatment of vulvar cancer, which serves to conduct dynamic monitoring of patients and after anticancer therapy to make a determination in daily urine excretion of melatonin (patent No. 253175, BI No. 20 of 20.07.2000,). The method allows high accuracy to determine existing disease recurrence in a sharp increase levels of the hormone. There is a method allows to identify existing relapse, with its clinical manifestation. However, it is not possible to predict the occurrence of relapse. The aim of the invention is the detection of recurrence and/or metastases to their clinical manifestations. The goal is to reach a determination in daily urine of patients with laryngeal cancer indicators Androsterone and estradiol, calculate the ratio of Androsterone to estradiol. When the ratio is above 3 to predict recurrence or metastasis during the first year after the first stage of anticancer therapy. The ratio of Androsterone to estradiol below 3 indicates the long disease-free period. Comparative analysis of known methods of predicting recurrence of cancer of the larynx and claimed gives grounds to speak about the differences and the novelty of the developed method. The novelty of the "predictor of laryngeal cancer" is used to forecast the most variable of hormones. Androgens stimulate the development of laryngeal cancer, and estrogen inhibit it. The lower the ratio of the former to the latter, the more favorable will be the course of the disease. To identify this in the weft urine to determine the ratio of Androsterone to estradiol. When the index is above 3 to predict recurrence or metastasis in the near future, and a score of below 3 corresponds to the long-term relapse-free period. In open sources information of Russia, CIS and foreign ways, a similar offer could not be found. Developed a Method for predicting the recurrence of laryngeal cancer is industrially applicable. It can be reproduced and repeated many times in hospitals General medical network and specialized institutions with cancer. The method is as follows. The patient, who is in the hospital, collected during the day the urine. Next, the method Dingemans modification Zelensky determine the rate Androsterone. Method Brown in the modification Savchenko - estradiol levels. Calculate the value of the ratio of Androsterone to estradiol and its value above 3 predict disease recurrence or metastasis during the first year after the combined treatment. The ratio of Androsterone to estradiol below 3 indicates the long disease-free period. An example of a specific application of the method can serve as a statement of case histories. 1. Patient P., born in 1954, the case history No. 20087/O was admitted to the Department of head and neck tumors, RNII 19.02.2002, 4.06.2003, the patient is enrolled at RNII diagnosed with cancer of the larynx St, chronic stenosis. 4.06.2003, urgent tracheostomy. 9.06.2003, the extirpation of the larynx. Histological analysis: squamous cell carcinoma with keratinization. The postoperative period was uneventful. 23.06.-13.07.2003 - radiotherapy in total focal dose of 40 Gy. 14.07.2003, - the patient was discharged in satisfactory condition at the place of residence. 26.09.2003, - a patient admitted to the hospital for follow-up research. Collected daily urine of the patient. 27.09.2003, performed biochemical urinalysis. The level Androsterone - 18,55; estradiol - 3,5, the first to the second with 5.3. The patient was prescribed a course of chemotherapy. 15.12.2003, - during the inspection. Right in the surgical scar - dense enlarged lymph node up to 2.5 cm in diameter without clear boundaries, limited mobility. Cancer metastases in the paratracheal lymph nodes of the neck. Recommended to continue polychemotherapy. 2. Patient M., born in 1956 history No. 17699/t was admitted to the Department of head and neck tumors, RNII 15.09.2004 years with a diagnosis of cancer of the larynx St - chronic stenosis. 17.09.2004, the extirpation of the larynx. Histological analysis: squamous cell carcinoma with keratinization. The postoperative period was uneventful, the wound healed by first intention. 1.10.2004 year the patient was discharged in satisfactory condition. the URC to control the inspection in a month. 25.12.2004 year - on examination, the patient data for recurrence or metastasis no. The patient's condition is satisfactory. Active, working at home, in the garden. 26.12.2004, - a study of daily urine of the patient. Defined indicators Androsterone - 7,35 µmol/day. and estradiol - 2,92 nmol/day., their ratio of 2.55. 24.03.2005 some, is at the control examination of the patient of disease recurrence or metastasis was not detected. The condition is quite satisfactory 15.04.2005, - the patient feels well. Clinical data for recurrence no. The proposed method of monitoring the condition of the patient after treatment were traced 17 patients. In each case, the level of Androsterone to estradiol was possible to determine the direction and intensity of the malignant process. Technical and economic efficiency "method of predicting recurrence of laryngeal cancer" allows you to: - in the absence of clinical symptoms to predict disease recurrence; - to take measures to individualize therapeutic effects. A method for predicting recurrence of cancer after surgical removal of the tumor, including biochemical analysis of daily urine of the patient, wherein the patient in daily urine to determine the level of Androsterone to estradiol and led the ine relationships above 3 predict the occurrence of disease recurrence or metastasis in the near future; when the index is below 3 a long disease-free period.
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