Method for predicting ectopia of uterine cervix in females of reproductive age |
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IPC classes for russian patent Method for predicting ectopia of uterine cervix in females of reproductive age (RU 2306569):
Method for predicting hollow follicles syndrome / 2302639
Method involves determining luteinizing hormone concentration, follicle-stimulating hormone concentration, estradiol concentration, progesterone concentration, testosteron concentration in blood according to program ECO during the first days of menstrual cycle before superovulation stimulation. Prognostic criterion is calculated using the obtained data PC=ехр(K)/(1+ехр(K)), where Ехр(х) is the exponential function, K is the intermediate variable calculated from formula K=0.423+0.02хLG- 0.189хfSG-0.421хE2+0.3хP1-0.987хТs, where LG is the luteinizing hormone concentration in blood, IU/l; fSG is the follicle-stimulating hormone concentration in blood, IU/l; E2 is the estradiol concentration in blood, nmole/l; P1 is the blood progesterone concentration, nmole/l; Ts is the testosteron concentration in blood, ng/ml. Empty follicles syndrome is predicted using calculated PC value less than 0.5.
 Method for predicting clinical mammary gland carcinoma course / 2300111
Method involves determining tumor cells percent and estimating receptor color in semi-quantitative way. Positive cells proportion is recorded and reaction intensity is determined from formula H=3xA+2xB+1xC, where A is the intensively stained nuclei percent; B is the moderately stained nuclei percent; C is the mildly stained nuclei percent. Receptor distribution is determined in addition in tumor units of mammary gland carcinoma. Sites of positive and negative expression and various expression intensity sites being found, the expression is considered to be heterogeneous. Uniform receptor distribution being observed in the tumor irrespective of staining intensity degree, the expression is considered to be homogeneous. Homogeneous steroid hormone receptor expression being observed in tumor, favorable clinical disease treatment course is to be predicted. When heterogeneous, the prognosis is unfavorable.
Method for detecting extracranial metastases in metastatic brain injury patients / 2300110
Method involves determining cortisol hormone concentration in cerebral metastasis-ill patient blood prior to treatment beginning. Its concentration being found within the limits of 54.0 to 130.0 nmole/l, metastatic lesion foci are predicted to be available in other internal organs and tissues.
Method for predicting cerebral metastasis lesion foci in metastatic brain injury patients / 2300109
Method involves determining thyroxin hormone concentration in cerebral metastasis-ill patient blood prior to treatment beginning. Its concentration being found within the limits of 68.0-115.0 nmole/l, 1 to 3 metastatic lesion foci are predicted to be available. The concentration being from 38.0 to 50.0 nmole/l, more than 4 p metastatic lesion foci are predicted to be available.
Method for predicting extracranial metastases development in patients having metastases in brain / 2297005
Method involves determining adrenal glands cortex hormone cortisol content in blood. At its level below the bottom border of the norm making from 260.0 up to 450.0 nmole/l, within the limits of cortisol concentration fluctuations from 70.0 to 240.0 nmole/l, extracranial metastases development are predicted to occur in 1-3.5 months after primary examination.
Method for predicting physical growth and development of small children / 2291444
Method involves determining triiodothyronine content in peripheral blood serum of children of the second half-year of life having perinatal central nervous system injury manifestations and no signs of hypothyroidism. The value being equal to 0.69±1.34 ng/ml, the children are predicted to have small height to the third year of life.
 Method for carrying out monitoring of diabetes mellitus patients state and neurological and vascular complications development / 2291437
Method involves determining immune reactivity of blood serum with respect to insulin, to anti-insulin antibodies or their antigen-binding fragments, to anti-anti-insulin antibodies binding the antibodies to insulin and antigens to growth factor or their antigen-binding fragments and ANCA antigen. Blood serum immunoreactivity increase with respect to parameters under measurement relative to norm is used for determining diabetes mellitus neurological and vascular complications development.
 Method for predicting the phases of stress states / 2288475
In patient's blood one should detect the concentration of cortisol and fertile factors α2-microglobulin (AMGF), trophoblastic β1-1-glycoproteide (TBG) and α1-placental microglobulin (PAMG-1). The phases of stress states should be diagnosed by the coefficient calculated due to dividing the sum of AMGF and TBG concentrations by the sum of PAMG-1 and cortisol concentrations, moreover, the concentration should be expressed in % against average values in healthy persons. Coefficient's value being equal to 1.0-11 corresponds to the norm; at its value being 1.2-1.5 one should diagnose the phase of anxiety; at 0.7-0.9 - the phase of resistance; at 0.2-0.6 - the phase of exhaustion. The innovation provides the chance to program the flow of pathological process more accurately.
Method for predicting the development of gastrointestinal tract paresis in patients with vertebral traumas / 2286089
In patients with vertebral traumas for about 2-3 h after lesion one should simultaneously determine the level of hormone cortisol, malonic dialdehyde (MDA) in blood serum, and, also, the value of total bioelectric activity (TBEA) of gastrointestinal tract (GIT) and at cortisol values being 981.7 nM/l and higher, and MDA values - 8.35 mM/l and higher and values of TBEA being 387.75 mcV and lower it is possible to predict the development of GIT paresis.
Method for predicting the development of stress reactions in early neonatal period in neonatals born in females with urogenital infection / 2284526
In serum of peripheral blood in pregnant women in trimester III of pregnancy period it is necessary to determine serotonin concentration. The flow of stress reactions in early neonatal period in neonatals should be predicted at serotonin level being above 0.1 mcg/ml. Application of the present method provides the opportunity for earlier prediction of the development of stress reactions in neonatals in early neonatal period.
Method for differential diagnostics of mammary diseases in men / 2244308
The present innovation deals with biochemical trials: before the onset of therapy in men one should detect blood content of thyroid hormone - free thyroxine - and at its level being 10.3-12.9 pmol/l one should diagnose mammary cancer, at the level of free throxine being 18.7-31.0 pmol/l - one should predict gynecomastia. The method enables to detect the direction of pathological process and carry out due correction of therapy tactics in men with either gynecomastia or mammary cancer.
Method for predicting the delay of intrauterine fetal development / 2246733
The method deals with studying blood serum of pregnant woman to detect the content of insulin-like growth factor (IGF) and vascular-endothelial growth factor (VEGF) and calculate the coefficient of their ratio: at its value being equal to 28.5 and lower it is possible to diagnose the delay of fetal development.
Method for differential diagnostic of chronic hepatitis and hepatic cirrhosis / 2254577
Thyroglobulin content is determined in blood serum using enzyme immunoassay. When thyroglobulin level is increased by 2 times and more compared in contrast with normal one chronic hepatitis is diagnosed, and when thyroglobulin level is decreased by 1.5-2.5 times in contrast with normal one hepatic cirrhosis is diagnosed.
Method for evaluating combined schizophrenia treatment based on atypical antipsychotic drugs and rations and electroconvulsive shock therapy / 2256181
Method involves determining dehydroepiandrosterone sulfate concentration in blood serum. Its growth above 30% when compared to the initial one being observed, treatment efficiency is determined as negative.
Method for diagnosing obliterated forms of congenital suprarenal gland cortex hyperplasia / 2261447
Method involves applying high effectiveness liquid chromatography for determining cortisol, cortisone 11-deoxycorticosterone, 11-deoxycortisone concentration in blood and free cortisol and free cortisone excretion with urine. Ratios of F/E and FF/FE are calculated, where F is the cortisol level in blood; E is the cortisone level in blood; FF is the free cortisol excretion with urine and FE is the free cortisone excretion with urine. The cortisol level in blood not exceeding norm and at least two of three signs: F/E ratio reduction by 25% and more, FF/FE ratio reduction by 25% and more, free cortisol excretion with urine being equal to 25% and more, obliterated forms of congenital suprarenal gland cortex hyperplasia is diagnosed. Corticosterone level in blood growing by 50% and higher, 21-hydroxylase defect is considered to be the case. 11-deoxycorticosterone and/or 11-deoxycortisone concentration in blood being et or greater than 50%, 11β-hydroxylase defect is considered to be the case.
 Method for diagnosing atrophic gastritis cases / 2262706
Method involves making pepsinogen 1, gastrin and Helicopter pylori infection marker combinations analysis and making input of the obtained results into data processing means comprising operation system, means for receiving, transmitting and processing data. The mentioned data processing means is usable for comparing the measured concentration value of a substance under study to a threshold value associated to the substance under study and producing information as a response to comparison results and additionally to other entered data. A set and software are used for implementing the method.
Method for predicting relapse of mammary cancer / 2263319
In the course of surveying in menopausal women after complex therapy one should state the development of mammary cancer at decreased ratio of estriol concentration to the sum of estrone and estradiol urinary concentrations from 1.68±0.23 in relapse-free patients up to 0.74±0.12 - in patients living without relapses for less than a year, up to 0.65±0.13 in patients living without relapse from 2 up to 6 years and up to 0.50±0.10 in patients with relapse-free period from 6 to 10 years. The innovation provides pre-clinical detection of mammary cancer relapse.
Method for predicting fetoplacental insufficiency in pregnant women with thyroid diseases / 2263919
Except detecting placental lactogen in blood serum one should study the content of alphafetoprotein. At placental lactogen content being below 75% against the norm and content of alphafetoprotein below 70% against the norm it is possible to conclude upon availability of fetoplacental insufficiency.
Method for predicting cholecystitis and cholelithiasis / 2263920
While diagnosing cholecystitis and cholelithiasis due to ultrasound testing one should additionally study blood plasma and bile to detect there the content of prostaglandins PGE2 and PGF2α. At PGE2/PGF2α ratio in blood plasma being equal to 6 and more, and, also, at decreased level of biliary cholecystokinin-pancreosimin by 38% and more, biliary PGE2 by 59% and more and increased level of biliary prostaglandin PGF2α by 5.9 times and more against the norm one should diagnose chlecystitis and cholelithiasis. The innovation enables to detect the above-mentioned diseases at earlier stage.
Method for predicting powerless labor in pregnant nodular goiter surgically treated on goiter occasion during pregnancy under medical supervision / 2273456
Method involves determining thyroid gland node diameter and thyrotropic hormone by applying ultrasonic examination approach. Histological examination is carried out with conclusion concerning morphologic nature being obtained like nodular colloid proliferating goiter or thyroid gland adenoma. Diagnostic index Σ is calculated from formula Σ=0.49*K1+0.07*K2-0.5*K3+1.76*K4-1.53, where K1 is the thyroid gland node diameter; K2 is the TTH concentration; K3 is the nodular colloid proliferating goiter index equal to 1 or 0; K4 is the thyroid gland adenoma index equal to 1 or 0. Diagnostic index Σ being less than zero, conclusions concerning powerless labor threat is to be drawn.
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FIELD: medicine, gynecology. SUBSTANCE: it is necessary to monitor the content of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), progesterone (P) in blood serum on the 7th, 14th, 21st d of menstrual cycle due to immunoenzymatic technique. At FSH values ranged 4.98-5.78 IU/l on the 7th d of menstrual cycle, 9.88-11.52 IU/l on the 14th d of menstrual cycle, 6.91-7.85 IU/l on the 21st d of menstrual cycle, LH ranged 5.11-5.75 mIU/l on the 7th d of menstrual cycle, 11.7-12.23 mIU/l on the 14th d of menstrual cycle, 5.66-7.18 mIU/l on the 21st d of menstrual cycle, E2 ranged 41.28-44.93 pg/ml on the 7th d of menstrual cycle, 134.78-143.92 pg/ml on the 14th d of menstrual cycle, 98.91-109.29 pg/ml on the 21st d of menstrual cycle, Pranged 1.02-1.53 nM/l on the 7th d of menstrual cycle, 1.31-1.79 nM/l on the 14th d of menstrual cycle, 6.80-7.16 nM/l on the 21st d of menstrual cycle one should diagnose the ectopia of uterine cervix in females of reproductive age. EFFECT: higher accuracy of diagnostics. 1 ex, 2 tbl
The invention relates to medicine, namely to gynecology. Ectopia is a background disease of the cervix, in which the epithelium has areas covered with cylindrical epithelium. According to the preventive examinations of the cervical ectopia (ASM) occurs in 38,8%, gynecological diseases in 42.2% of women. In nulliparous women under 25 years of ASM detected in more than 50% of cases. Due to the multifactorial nature of the causes of ASM and the fact that the disease in some women are asymptomatic or identifies symptoms similar to other diseases, patients undergoing complex. It is known that bacteriological and bacterioscopic, cytological methods are used to diagnose ASM [1]. However, for the diagnosis of ectopia of the cervix in women of reproductive age immunoassay method for the study of blood serum in a comprehensive study, the patient was not applied. The technical result of the invention is more accurate diagnosis of ASM. The technical result is achieved by using the immunoassay method of the analysis of blood serum in a comprehensive study of the patient. Proposed method for the diagnosis of ectopia of the cervix in women of reproductive age, is characterized by the study of the content folliclestimulating hormone(FSH), luteinizing hormone (LH), estradiol (E2), progesterone (P), in serum on days 7, 14, 21 days of the menstrual cycle by ELISA, while the testimony folliclestimulating hormone from 4,98 to 5,78 IU/l on day 7 of the menstrual cycle, from 9,88 to 11.52 IU/l on day 14 of the menstrual cycle, from 6,91 to 7.85 IU/l on day 21 of the menstrual cycle, luteinizing hormone from 5,11-5.75 mIU/l on day 7 of the menstrual cycle, from 11,17 to 12,23 IU/l 14 day of the menstrual cycle, from 5,66 to 7.18 IU/l on day 21 of the menstrual cycle, estradiol from around 41.28 to 44,93 PG/ml on day 7 of the menstrual cycle, from 134,78 to 143,92 PG/ml on day 14 of the menstrual cycle, from 98,91 PG/ml to 109,29 PG/ml on day 21 of the menstrual cycle, progesterone from 1,02 to 1.53 nmol/l on day 7 of the menstrual cycle, from 1.31 to 1.79 nmol/l on day 14 of the menstrual cycle, from 6,80 to 7,16 nmol/l on day 21 of the menstrual cycle was diagnosed with the ectopia of the cervix. The method is as follows. Conducted a retrospective evaluation 252 outpatient cards women of reproductive age with ASM, a comprehensive survey of the 45 women, of whom 30 from ASM (main group) and 15 healthy (control group). In the work of applied clinical and special gynaecological examination. The content of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2/sub> ), progesterone (P) in serum were examined by an enzyme immunoassay (ELISA) for 7, 14 and 21 day menstrual cycle. The results of the study are presented in table 1, 2. The content of FSH in the serum of women main and control groups did not differ significantly (table 2). The content of LH at 14 and 21 days of the menstrual cycle in patients with ASM was lower than in the control group (P<0,05). The contents of F2in the control and main groups corresponded to the phase of the menstrual cycle (table 1), but in the main group on the 7th and 14th day was lower than in the control (P<0,05). A similar pattern was observed in the content of P (table 1). When significantly less P in the studied days of the menstrual cycle in women with ASM in comparison with the control group on day 21 its content was 2 times lower and amounted to 6,98±0.18 nmol/l and 12,98±2.68 nmol/l (P<0,05), respectively. Example. Patient K., Aged 25 years. Complaints of discharge from the genital tract, itching and burning in the vulva, painful urination. A history of chronic vaginitis, cervitec. When viewed on the mirrors: cervix erozirovanne, deformed old breaks. Bacteriological examination of the content of servicelogger channel identified vaginitis. Colposcopic conclusion - the prevalence of cylindrical epithelium, we submit that the key inflammation. For a more accurate diagnosis conducted by the method of enzyme blood tests. Performance analysis of blood serum. FSH on day 7 of the menstrual cycle 5, 27, 14 day - 9,99, on the 21st day of 6.96. LH on day 7 - 5, 67, 14 day 11, 57, 21 day - 7,10. E27 day - 44,42, on the 14th day - 137,38, 21 day - 101,49. P on the 7th day - 1,06, on the 14th day to 1.47, 21 day - 6,98. Diagnosed with ectopia of the cervix. The diagnosis is confirmed by bacteriological, cytological methods, videocolposcopies, histological verification. The application of the research method ELISA serum was allowed to make an accurate diagnosis.
Sources of information 1. Kauhava, E. N. and other Modern approaches to diagnostics and treatment of ectopia cervix // ROS. Vestn. Obstetrician-gynecologist.- No. 6, 2006. Method for the diagnosis of ectopia of the cervix in women of reproductive age, is characterized by the study of the content folliclestimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), progesterone (P), in serum on days 7, 14, 21 days of the menstrual cycle by ELISA, while the testimony folliclestimulating hormone from 4,98 to 5,78 IU/l on day 7 of the menstrual cycle, from 9,88 to 11.52 IU/l on day 14 of the menstrual cycle, from 6,91 to 7.85 IU/l on day 21 menstrual cycle, luteinizing hormone from 5,11-5.75 mIU/l on the 7th day of the menstrual cycle, from 11,17 to 12,23 mIU/l on the 14th day of the menstrual cycle, from 5,66 to 7.18 mIU/l on day 21 of the menstrual cycle, estradiol from around 41.28 to 44,93 PG/ml on the 7th day of the menstrual cycle, from 134,78 to 143,92 PG/ml on the 14th day of the menstrual cycle, from 98,91 PG/ml to 109,29 PG/ml on day 21 of the menstrual cycle, progesterone from 1,02 to 1.53 nmol/l on day 7 of the menstrual cycle, from 1.31 to 1.79 nmol/is on the 14th day of the menstrual cycle, from 6,80 to 7,16 nmol/l on day 21 of the menstrual cycle was diagnosed with cervical ectopia.
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