Suppositories with bee moth larvae extract and bee-glue extract for treating gynecopathies |
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IPC classes for russian patent Suppositories with bee moth larvae extract and bee-glue extract for treating gynecopathies (RU 2429867):
Method of treating degree 1 discirculatory encephalopathy complicated by climacteric syndrome / 2429856
Treating degree 1 discirculatory encephalopathy complicated by climacteric syndrome is enabled by a therapeutic course of systemic ozone therapy consisting of 5 intravenous drop infusions of ozonised 0.9 % sodium chloride at rate 8-10 ml/min. The procedures are daily in the ozone concentration in physiologic saline 400 mcg/l. A single ozone dose introduced in a vascular bed for one infusion is 160 mcg, a course dose is 800 mcg. Thereafter, the preparation Climadinone 30 drops or 1 tablet is prescribed depending on presentation daily 2 times a day for 3 months.
 Pharmaceutical delivery systems for hydrophobic therapeutic agents and compositions containing it / 2429850
There are offered an oral pharmaceutical composition containing a) a testosterone ester and a fatty acid ester of a medium chain size; and b) two or more lipid ingredients, at least first of which contains a hydrophilic surfactant and at least second of which contains a lipophilic surfactant; said lipid ingredients together provide solubilisation of said testosterone ester in amount 10-20 % of weight of a pharmaceutical composition; a method for prevention or release of testosterone deficiency symptoms in mammal subjects and a method for maintenance of prolonged oral testosterone release.
Method of preventing genitalia prolapse in women of reproductive period / 2427370
Invention relates to medicine, namely to gynecology and can be used for prevention of genitalia prolapse in women of reproductive period. For this purpose exercises strengthening muscles of pelvic floor are done. In patient content of C-end telopeptides is determined, hormonal status is analysed, for which purpose content of estradiole, free testosterone, 170Hprogesterone is determined in first phase of menstrual cycle. If level of free testosterone is normal, level of estradiole is normal or lower, content of 170Hprogesterone is higher, patients, who are not planning pregnancy, are administered Diane-35 or Jeanine in accordance with contraceptive scheme for six months. Patients, who are planning pregnancy, are administered dexamethasone daily in the evening for three months. If content of 170Hprogesterone is 3.1 - 4.4 nmol/l, daily dose of dexamethasone equals 0.125 mg, if content of 170Hprogesterone is 4.5-7.0 nmol/l - 0.25 mg of dexamethasone, if content of 170Hprogesterone is higher than 7.0 nmol/l - 0.5 mg of dexamethasone; if content of C-end telopeptides is higher than 0.6 ng/ml additionally administered is ascorbic acid in dose 500 mg 3 times per day, magnerot in dose 500 mg 3 times per day for three months.
Method of conservative treatment of women in premenopause period with prolapse of genitalia / 2427369
Invention relates to medicine, namely to gynecology and can be used for conservative treatment of women in premenopause period with prolapse of genitalia. In women in premenopause period with prolapse of genitalia, undergoing substituting hormonal therapy, level of C-end telopeptides is determined, if values are lower than 0.6 ng/ml, only substituting hormonal therapy is administered. If values equal and are higher than 0.6 ng/ml, additionally to substituting hormonal therapy administered is metabolic therapy in form of ascorbic acid in dose 500 mg 3 times per day and magnerot in dose 500 mg 3 times per day for three months. Additionally determined is amount of immunoglobulin E, circulating immune complexes, C3- and C4-components of complement. If level of immunoglobulin E is higher than 150 IU/ml, circulating immune complexes more than 200 units of optic density, C3-component of complement lower and equal 83 mg/dl, C4-component of complement lower and equal 18 mg/dl, to substituting hormonal and metabolic therapy additionally administered is vobenzim in dose 3 pills 3 times per day for three months.
Method of prevention and treatment of thread of abortion in women with uterus myoma in accordance with new conception of its etiopathogenesis / 2424817
Invention relates to medicine, namely to obstetrics and gynecology, and can be used for prevention and treatment of threat of abortion in women with uterus myoma. For this purpose patient is administered preventive wearing of Polish inserts "Piocal" for 8-15 hours per day. With beginning of pregnancy 5-7 hours per day. Simultaneously before pregnancy administered is "Dienay" in dose 1 capsule during 3 days. After that, 2 capsules 3 more days and on the following days in dose 2 capsules 2 times per day, course duration being 3 weeks. After 7-10 day break, administered is "Neurostrim" in dose 2 capsules in the morning and 1 capsule in the evening 30 minutes before meal with course 3-4 weeks. During pregnancy additionally administered is "Lohelan" - 20-30 minutes before meal, In dose one fourth of glass 2 times per day, with course of treatment 20 days, 2-3 courses during pregnancy, and "MIGI" - 1 tablespoon without dilution 3 times per day for 15 days, 1-2 courses for entire term of pregnancy.
Agent for treating dugs / 2423989
Invention refers to agriculture, particularly to veterinary science, and can be used in animal industries for mastitis prevention. An agent for treating dugs containing polyvinyl alcohol, differing by the fact that polyvinyl alcohol grade 11/2 is used, in addition contains 10 % liquid alkaline sapropel hydrolyzate and disinfectant liquid soap "Cleandesin-soft" in the following proportions, wt %: Polyvinyl alcohol grade PVA 11/2 2.0-6.0; 10 % liquid alkaline sapropel hydrolyzate 1-3; "Cleandesin-soft" 0.7-1.0; distilled water - the rest. After application, the agent dries up and forms a thin, strong enough film which is removed after washing the dugs with warm water prior to milking. The agent promotes a soothing effect on dug skin, stimulates wound repair and cracked dug healing and provides an effective mastitis prevention in cows.
Method of treating chronic recurrent vulvovaginitis / 2423978
Invention relates to medicine, namely to dermato-venerology and gynecology, and can be applied for treatment of chronic recurrent candidal vulvovaginitis. For this purpose together with antifungal medications inside prescribed is antihistaminic medication erius in day dose 5 mg for 10 days. Then, monthly 5 days before menstruation and during 5 days after it. After that, in pills in day dose 5 mg inside for 6 months.
Method of childbirth induction on gestation term 22-27 weeks in case of pouring out of amniotic fluid / 2423973
Invention relates to medicine, and namely to obstetrics and gynecology, and can be applied for induction of childbirth. For this purpose per orally mifepristone is taken on first day in dose 200 mg three times after every 4 hours. One day after first intake of mifepristone in back fornix of vagina introduced is dinoproston 1 mg.
 Medication for treating endometriosis / 2423146
Claimed is application of dopamine agonist (for instance, amantadine, bromocriptine, cabergoline, quinagolide, lisuride, pergolide, ropinirole and pramipexole) for production of medication for treatment and prevention of endometriosis.
No donor and dithiolane-containing compositions and their application for improvement of sexual function / 2423120
Invention relates to pharmacology and represents peroral composition, including L-arginine and R-α-lipoic acid in effective amount, where L-arginine is present in molar excess with respect to amount of R-α-lipoic acid present in composition.
Derinat suppositories to be used in medical practice / 2429854
For treating urogenital clamidiosis, cytomegalovirus, herpes simplex, Helicobacter pylori, polyethylene oxide 1500 and polyethylene oxide 400 are melted in the ratio 9:1; the liquid melt is added with a design amount of the preservative sodium chloride; further a design amount of sodium deoxyribonucleate is added in mixing. A melted paste is mould to prepare Derinat suppositories of 1.3-2.5 g.
Pharmaceutical composition for treating diseases of lower part of genitourinary system / 2428173
Invention relates to pharmacology and medicine and represents pharmaceutical composition for treating diseases of lower part of genitourinary system in form of suppositories, which includes bioactive compound and fat basis, characterised by the fact that as bioactive compound, composition contains mixture of amino acids: glutamic acid, lysine, alanine, arginine and glycine, and additionally zinc in form of zinc chloride, components in composition being in specified ratio per one suppository with weight 2.7-2.9 g.
 Anti-tuberculosis medication based on 4-thioureidoiminomethylpyridinium perchlorate, method of its obtaining and method of treatment / 2423977
Invention relates to field of chemical-pharmaceutical industry, namely to novel anti-tuberculosis medication. Claimed medication contains as active substance 4-thioureidoiminomethyperidinium perchlorate in effective and safe quantity and pharmaceutically acceptable auxiliary substances. Also claimed is method of its obtaining, which makes it possible to obtain target product with high yield. Novel medication, obtained by claimed method, possesses high tuberculostatic activity and low toxicity, preserves its stability in long-term storage.
Method of treating nonspecific aerobic vaginitis / 2422147
Claimed is method of treating nonspecific aerobic vaginitis by vagina sanitation with medication "Bioprost" in dose 1 suppository per night for 10 days. Method ensures complex therapeutic effect due to anti-inflammatory action of pumpkin seed oil, improving vigaina microecology, and thymol, which suppresses development of Gram-positive, Gram-negative bacteria, fungi, and possesses activity with respect to protozoa and herpes virus.
Suppositories for treating proctologic and gynecologic diseases / 2421210
Invention refers to suppositories for treating proctologic and gynaecologic diseases. Said suppositories contain a drug in the form of the dehydrated preparation 'Baliz' or a power-predried form of the preparation 'Baliz', or an active substance pre-recovered from the preparation 'Baliz' in the form of comenic acid or its salts, and also a base representing fatty substances, and a food or medicinal emulsifier.
Pharmaceutical composition containing hyaluronidase and liposomes for external application / 2417097
Invention refers to pharmacy, namely to a pharmaceutical composition for local application, containing enzyme hyaluronidase which can be used in pharmacy for treatment and prevention of inflammatory prostate diseases, such as prostatitis. The pharmaceutical composition for local application contains as an active ingredient hyaluronidase 2.44 wt %, Tween-80 2.93 wt %, PEG-1500 91.69 wt %, liposome 2.44 wt %, and pharmaceutically acceptable carriers or excipients, such as benzydamine 0.5 wt %.
Immunocorrective agent for treating diseases of viral aetiology / 2411039
Invention refers to pharmacology and medicine. Substance of the invention consists that an immunocorrective drug exhibiting an intense specific antiviral activity for treating diseases of viral aetiology contains human recombinant interferon alpha and/or beta, and/or gamma, an antioxidant complex of tocopherol acetate or its derivative, including water-soluble ones, and ascorbic acid salts, calcium pantothenate, antiviral ingredients, as well as pharmaceutical aids and excipients in certain ratios in 1 g of the drug. As antiviral ingredients, the drug contains arbidol and its derivatives, remantadin, oseltamivir, ribavirin, inosine pranobex (isoprinosine), glycyrrhizic acid and its derivatives, nucleosides of a group - famvir, valacyclovir, ganciclovir, valganciclovir, foscarnet, cidofovir, lobucavir, sorivudine, brivudine, antiretroviral - lamivudine, zidovudine, lopinavir, stavudine. The agent is presented in rectal and vaginal suppositories, gel, ointment, liquid.
Drug preparation tilorone in suppositories / 2411032
Invention refers to a pharmaceutical industry, and concerns making a preparation Tilorone in the form of rectal suppositories 125 mg, being an antiviral immunostimulant.
 Food additive for supply of nutritional mineral substances / 2409991
Food additive characterised by the minerals it contains being a component of a salt hydrate melt in the form of ions, the said nutrient substances represented by at least calcium; the salt hydrates melt is amorphously hardening and is represented by a salt-water system with water content in the food additive corresponding to the most hydrated ion coordination number. The food additive is used as admixture during production of food products, chewing gum, beverages, toothpaste, mouth wash liquids and oral cavity hygiene products. The nutrient mineral substances are easily digestible due to their containment in the additive in ion form.
Method of treating chronic prostatitis / 2408378
Invention refers to medicine, namely to urology, and can be used for treating chronic bacterial non-Chlamidia prostatitis. That is ensured by the integrated treatment that involves antibacterial therapy and administration of Interferon A in the form of ointments or suppositories. The therapeutic course is 7 days to be repeated in a week.
Method for producing diagnostic allergen / 2428197
Invention refers to pharmacology and medicine, namely to a method for producing diagnostic allergens of a number of synanthropic insects, such as: Blattella germanica, Blatta orientalis, Pertplaneta americana cockroach Neuphoeta cinerea, Musca domestica, Tinea pelionella, Cimex lectularis, Monomorium pharaonis, Tegenaria derhami, Culex pipiens, Attagenus Smirnovi Zhan. For the method for producing the diagnostic allergen, initial raw materials are frozen synanthropic insects. The initial raw materials are grinded to particle size 1-3 mm, degreased by addition of ether in the ratio 1:3-4 to the raw materials; the raw materials are kept in ether during 15-20 min that is followed by removal of ether by mixture filtering; the raw materials are degreased again by ether, dried to complete ether removal; the completely fat-free raw materials are powdered. The prepared powder is extracted in two stages; the first stage involves pouring the powder with an extractant liquid 1:1 and mixing to a homogeneous suspension; and the second stage includes mixing the prepared suspension with the extractant liquid in the ratio 2:1 and agitating by shaking the suspension three times for 30 minutes every 1.5 hours at temperature 2-10°C for 3 days with daily correction of the pH value of the allergenic extract to 7.0-7.2.
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FIELD: medicine. SUBSTANCE: suppositories contain 5 % ethanolic extract of bee moth larvae, 5 % ethanolic extract of bee-glue, Lutrol F 68, polyethylene glycol 4000 and Cremophore RH-40 in the following proportions, g: 5 % ethanolic extract of bee moth larvae - 0.09; 5 % ethanolic extract of bee-glue - 0.09; Lutrol F 68 - 0.75; PEG 4000 - 1.0; Cremophore RH-40 - 1.25. EFFECT: suppositories exhibits a wide spectrum of biological and medical activities: immunomodulatory, antistress, antioxidant, regenerative and antibacterial action improving microcirculation, blood rheology and utero-placental circulation, provide uniform active ingredient release, evident prolonged action and individual usability. 1 cl, 3 ex
The present invention relates to medicine, namely to the pharmacy, and concerns the development of medical suppositories containing extracts of large larvae of the wax moth (LBVM) and propolis, and can be used in complex treatment of inflammatory diseases of female sexual sphere (salpingoophoritis, endometritis, infertility, menopausal disorders, correction of the various manifestations of placental insufficiency in the combined treatment of threatened abortion. Known gynecological of ovule for complex treatment of inflammatory diseases of female sexual sphere, made in the form of capsules, including gelatin, glycerin and purified water weight 2.5 g, and containing as active ingredients BHT and oil extract of propolis 15% (patent RU 2249449, 2005). The invention provides getting dosed means having a prolonged regenerative and anti-bacterial action, convenient and hygienic to use. Know the treatment for non-inflammatory and inflammatory diseases of female pelvic organs, including complications of purulent-inflammatory processes in the form of vaginal suppositories containing the active substance 2-ethyl-6-methyl-3-oksipiridina succinate and a base selected from the group of the polyethylene shall noxid 1500, the polyethylene oxide 400, cocoa butter, hydrogenated fats (patent RU 2293558, 2007). The invention provides a prolonged release of therapeutic drug in the mucous membranes and soft tissues, and provides the action for about 12 hours, while the procedure itself is comfortable and easy to perform and can be done by patients themselves in the outpatient setting. The prototype of the invention are suppositories for the treatment and/or prevention of gynecological diseases, characterized in that the active substances they contain pharmaceutical composition comprising propolis, naphtha, essential oils of calendula, St. John's wort, eucalyptus, cedar, tea tree, buckthorn and tocopherol acetate, the extracts of the fruits, tomatoes, currants, licorice, periwinkle, lady's bedstraw, calendula and TUI at a certain ratio of components, and as a basis they contain cocoa butter or tallow (application EN 2006132907, publ. 2008). The disadvantages of these suppositories are complexity, the complexity of the composition and process of production of a receipt. The objective of the invention is to create a new dosed medications domestic production in the form of suppositories containing extract VVM and propolis extract, possessing a wide spectrum of biological and l the educational activity, immunomodulatory, anti-stress, antioxidant, regenerating and anti-bacterial effect, improves microcirculation, blood rheology and utero-placental circulation, with a uniform release of active substances and severe prolonged action, suitable for use by patients themselves. The technical result - obtaining means expressed prolonged action for comprehensive treatment of patients with inflammatory diseases of female sexual sphere, convenience and hygiene applications. This technical result is achieved in that the means in the form of suppositories for the treatment of gynecological diseases, containing propolis as active substance and vegetable oil as the basis, according to the invention as propolis contains 5% alcohol extract of propolis and additionally contains as active ingredient 5% alcohol extract of larvae of the great wax moth, and as a vegetable oil contains cremophor RH-40 and additionally as the basis contains lotrel F 68 and polyethylene glycol 400 in the following ratio of components 1 suppository, g:
All components included in the suppositories allowed for medical use. Lotrel F 68 BASF (Germany) 9003-11-6. Lutrol®F 68 - hydrophilic polymer, a block copolymer of polyoxyethylenesorbitan, available in granular form with an average particle size of about 1000 microns, while the non-crystalline active ingredients have a particle size in the range of 20-200 microns. One of the physical methods of increasing the solubility of the active ingredient is to increase surface by micronisation. Another way is the use of solubilization, such as surface-active polymers - poloxamer. Cremophor RH-40 BASF (Germany) P # 013635/01-2002. Cremophor®RH-40 - ethoxylated hydrogenated castor oil, included in the Pharmacopoeia of the United States called "Polyoxyl 40". It is used as a solubilizer has the ability to enhance the pharmacological effect of drugs that can reduce their doses, can eliminate n the compatibility of the ingredients in the compositions. Has an absolute stability in hard water, in the majority of polling emulsifying, wetting and solubilizing ability, relatively low toxicity and other Polyoxyethyleneglycol (PEG) 4000 TU 2483-166-05757587-2000. In the pharmaceutical industry is used as an auxiliary substance for the production of pharmaceuticals. Used as a thickener, softener, binders, moving and facilitate outflow of the agent, and as a solubilizer has no emulsifying effect. Propolis is THE GOST 28886-90. The introduction of the suppositories drug propolis extract alcohol in the amount of 3% in combination with an extract LLVM increases antimicrobial activity, tissue regeneration, promotes the expression of analgesic, hemostatic, immunomodulating, reparative effect of the dosage form. The alcohol extract of the larvae of the wax moth. Patent N 2038086, 1995. "A method for obtaining a biologically active product of the large larvae of the wax moth". Extract the larvae of the wax moth contains a large set of macro - and micronutrients. Among them, potassium, phosphorus, magnesium, zinc, iron, and trace elements with high biological activity - copper, manganese, selenium, chromium, molybdenum, cobalt. The number of essential and non-essential acids of devjatnadcat is. Among them are amino acids, with the highest therapeutic effect: Proline, aspartic and glutamic acids, lysine, histidine. These amino acids necessary for protein synthesis, hormones, enzymes, etc. They also have a positive effect on tissue metabolism. Gamma-aminobutyric acid has anti-stress activity. Biological active compounds, such endogenous steroid hormones have an anabolic, adaptogenic, hypocholesterolemic action, as well as immunomodulatory, anti-stress, antioxidant effect, improves microcirculation, blood rheology, improve uteroplacental blood flow, and with a wide range of biological and therapeutic activity. The following preparations containing alcohol extract LLVM: balsam Dr. Mukhina, complex drug "Vita" in the form of tinctures of medicinal plant raw materials containing dandelion root, motherwort, cottonweed marsh, hawthorn flowers, grass of a horsetail herb mistletoe, the leaves of the periwinkle, yarrow herb, Cystoseira bearded, herb Rue, the herb cinquefoil goose, flowers of Arnica, St. John's wort herb, caraway seeds, leaves, lemon balm, Valerian root, flowers, Lily may, grass creeping thyme, chamomile flowers, mint leaves is arachnoi, digitalis lanata, fennel, hops, grass spring Adonis in combination with an extract LLVM /Accacco, Masakova. Apitherapy. Manual for doctors. Ryazan. - 2003. - S./; balsam Dr. Rachkova, "Vetmedin"that contains honey extract LBWM, complex drug "Galery with extract LLVM /Accacco, Masakova, Trading, Ayiguenou. Perspectives and advances in the use of therapeutic and prophylactic preparations based on extracts of large larvae of the wax moth. - S-281; Apitherapy today (publication 13). Proceedings of the XIII all-Russian scientific-practical conference "Successes apitherapy". Fish. - 2008./, with a wide range of biological and therapeutic activity. therapeutic effect of these tools is not prolonged action due to liquid consistency and is used in the form of tinctures for internal use, which is inconvenient in use, the funds are not dosed for a single admission, intended for internal use and not intended for intravaginal way of introduction. In the available scientific and medical and patent literature information about known drug for treatment of gynecological diseases in the form of suppositories containing alcohol extract large larvae of the wax moth, alcohol extract of propolis, Lutron F 68, polietilen icol 4000 and cremophor RH-40 at a certain ratio of components, not found. Thus, the claimed invention meets the criterion of "novelty". As a result of experimental studies, it was found that the tubes have a high bioavailability and a number of advantages: they have a beautiful appearance, homogeneous, elastic, which is important for vaginal medicines; therapeutic effect of the extract VVM and propolis extract appears 5 minutes after administration; complete dissolution after 15 minutes. Suppositories are very promising for applications in gynecology. The composition suppozitornoj bases contributes to fast and then the prolonged release of active substances of the extract VVM and propolis extract. Giving the drug form of suppositories provides convenience and hygiene applications, the storage stability. Introduction in the drug extract LBVM in the amount of 3% in combination with propolis extract in the amount of 3% by weight of the basis increases antimicrobial activity, tissue regeneration, promotes the expression of analgesic, hemostatic, immunomodulating, anti-stress, antioxidant, improves microcirculation, blood rheology, improve uteroplacental blood flow, namely a wide range of biological and l the educational activity effective and efficient dosage forms. In addition to the manifestations of the known properties of each component of the proposed structure together strengthens their influence, because, obviously, the effect of their synergies. Thus, the claimed invention meets the criterion of "inventive step". Example 1. Part 1 suppository mass of 3.0±5% g: alcohol extract large larvae of the wax moth 0,09; alcohol extract of propolis 0,09; lotrel 68-0 F,75, PEG 4000 - 1.0; cremophor RH-40 1,25. In beaker melt lotrel F 68, PEG and cremophor RH-40 in a water bath at a temperature not exceeding 70°C. To remove air without mixing incubated for 30 minutes at a temperature of 45°C. the Extract LLVM alcohol and propolis extract alcohol injected into suppozitornyj mass, stirring constantly with a glass rod. Metal suppozitornoj form is wiped with a gauze pad moistened with vaseline oil, is cooled in a refrigerator at a temperature of 3-5°C for 5-6 minutes and pour cooked suppozitornyj mass at a temperature of 38-40°C for 1-2 seconds. Forms are placed in the refrigerator for 7-10 minutes, then frozen suppositories are removed. Quality suppositories appreciate the appearance, elasticity, homogeneity, solubility. Received suppositories correct form, solid and homogeneous. Full time dissolving 15 minutes. Have expressed prolongers the TES action due to the optimum composition framework that is, the active ingredients of propolis extract and the extract LLVM enter the body immediately and then kept on the mucosal surface for a certain period of time, provide long-term effects of drugs with intravaginal the introduction of the patient. Suppositories convenient and hygienic to use, because the proposed composition of the ingredients. Example 2. Part 1 suppository mass of 3.0±5% g: alcohol extract large larvae of the wax moth 0,09; alcohol extract of propolis 0,09; Lutron F 68-1,0; PEG-4000-1,0; cremophor RH-40 and 1.0. Made of medical suppositories in a similar way. Received suppositories irregular shape, the poor are removed from the forms and non-uniform. Example 3. Part 1 suppository mass of 3.0±5% g: alcohol extract large larvae of the wax moth 0,09; alcohol extract of propolis 0,09; Lutron F 68-1,25; PEG-4000-1,25; cremophor RH-40 0,5. Made of medical suppositories in a similar way. Received suppositories homogeneous, regular shape, the poor are removed from the forms, crumble, break. The given examples show that the optimal from the point of view of ease of application and the effectiveness of treatment is the composition described in example 1. Receive offer suppositories and easy when using DOS is ikaetsya this technical result. Thus, the claimed invention meets the criterion of "industrial applicability". Clinical trials have shown that the amount of released drug at a given ratio of components in one suppositories equally in patients studied. This allows the gynecologist in practical medicine, depending on the form and severity of the disease to recommend patients required number of suppositories for self-treatment, which makes the claimed suppositories promising dosage form in practical gynecology. For example, studies have been conducted on the use of suppositories in treatment of gynecological diseases of female genital sphere (salpingoophoritis, endometritis, infertility, menopausal disorders, correction of the various manifestations of placental insufficiency in the combined treatment of threatened abortion. It is possible to use suppositories sick yourself. Means in the form of suppositories for the treatment of gynecological diseases, containing propolis as active substance and vegetable oil as the base, characterized in that the quality of propolis it contains 5%alcohol extract of propolis and additionally contains as active ingredient 5%with litovoi extract large larvae of the wax moth, and as vegetable oil contains cremophor RH-40 and additionally as the basis contains lotrel F 68 and polyethylene glycol 4000 in the following ratio of components 1 suppository, g:
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