Feeding apparatus for nose

FIELD: medicine.

SUBSTANCE: feeding apparatus has part for closing of individual's stomatopharyinx palatal curtain and feeding part for supplying gas flow for entraining of substance into one of individual's nostrils under delivery pressure providing passage of gas flow around rear edge of nasal septum and exit from other nostril. Feeding part has tip including discharge pipe for feeding gas flow into one nostril, and sealing member for sealing one nostril relative discharge pipe so as to prevent gas flow from leakage through other nostril.

EFFECT: EFFECT: increased efficiency and enhanced reliability in operation.

60 cl, 9 dwg

The present invention relates to a feeding device and method of filing in the nasal Airways of human substances, in particular, or liquid in suspension or solution, or a powder containing a drug, particularly a pharmaceutical preparation for topical application, cleansing or flushing means in the form of a liquid, preferably combined with cleanser. In particular, the present invention relates to a feed of drug and flushing means to the mucosa of the nose, the anterior region of the nasopharynx, the openings of the sinuses wasp, the openings of the auditory tubes, the tubes of the sinuses, auditory tube, tympanic cavity and paranasal sinuses of a nose.

As shown in figure 1, the nasal airway 1 includes two nasal cavities separated by the nasal septum, numerous holes, such as holes 3 of the sinuses and the holes 5 of the pipe, and olfactory cells and lined with mucous membrane of the nose. Nasal airway 1 can communicate with the nasopharynx 7, the cavity 9 of the mouth and lower Airways 11, with the nasal airway 1 selectively communicated with the front region of the nasopharynx 7 and the cavity 9 of the mouth through the opening and closing of the oropharyngeal velum of the curtain 13. The uvula 13, which part is called soft sky is m, shown by the solid line in the closed position, achieved through the creation of a certain excess pressure in the cavity 9 of the mouth, for example, when moving through the cavity 9 of the mouth, and a dashed line in the open position.

There are many diseases of the nose, requiring treatment. One such disease is the inflammation of the mucous membrane of the nasal cavity, namely rhinitis, which can be allergic or non-allergic, often associated with infection and interferes with the normal functioning of the nose. For example, allergic or non-allergic inflammation of the mucous membrane of the respiratory tract nose can usually be exposed to 10-20% of the population, with the most common symptoms are swelling of the cavernous tissue of the nasal shell, tearing, secretion of watery mucus, sneezing and itching. It is clear that the blockage of the nose makes it difficult to breath through it and promotes breathing through the mouth, which leads to snoring and sleep disorders. Unfortunately, increasing the incidence of such allergic and non-allergic inflammatory disease. Other diseases of the nose consists of polyps in the nose, which arise from the sinuses, hypertrophic adenoids, secretory otitis, sinus disease and a reduced sense of smell.

In the treatment of certain diseases of the nose is preferred to the introduction of the medicine the funds for local use, especially, if the mucous membrane of the nose is the main way of penetration of the disease, as, for example, in the treatment or clogged nose. Indeed, the introduction of drugs for local application can successfully minimize the possible side effects of administering drugs for systemic use. Among the medicines that are usually delivered to local applications are protivozakonnye tools, antihistamines, cromoglicate, steroids and antibiotics.

Now an increasing number of adults and children rely on pharmaceutical drugs to relieve symptoms associated with diseases of the nose. Currently, among the known anti-inflammatory pharmaceuticals steroids for topical use, as proven effect on the blockage of the nose. In addition, the proposed anti-edema drugs for local application intended for use when removing the blockage of the nose. Also proposed treatment of hypertrophic adenoids and chronic secretory otitis media using anti-edema agents, steroids and antimicrobials for local use, although this is somewhat controversial. In addition, the introduction of pharmaceutical topical preparations used to treat or at least the OS is Alenia symptoms of inflammation in the anterior region of the nasopharynx, sinuses and ear tubes.

In addition to the supply of medicines, usually rinse the nasal mucosa liquids, in particular a saline solution to remove particles and secretions, as well as improving the activity of the ciliated epithelium of the nasal mucosa. These solutions can be used in combination with other active pharmaceutical agents.

In addition, currently more widely used supply of medicines to the entire body through the nasal passage, which provides a good way to supply pharmaceutical preparations for systemic use, such as hormones, such as oxytocin, and protivomigrenosny drugs, as a great flow and large surface area of the nasal mucosa successfully provide fast absorption in the entire body.

For feeding substances in the nasal Airways of people has developed a number of delivery systems.

Usually for the fluid containing the drug, or drilling fluid in the nasal Airways of people use sprays. However, the distribution of the delivered substances, particularly in the posterior region of the nasal airway, less than ideal, especially in cases of moderate or severe obstruction of the nose. It's a bad distribution is often even more Pilipets is because of the breath of a person through the nasal airway at the time of filing of the substance, as it is often prescribed in an attempt to deliver the substance to the posterior region of the nasal Airways. Indeed, a number of substances may be drawn into the lungs or swallowed every submission of a substance that can create problems in children, if the drug is a potent pharmaceutical product, such as a steroid, which often need to take. In addition, a jet is often directed to the nasal septum, which can lead to undesirable local deposition of substances. Moreover, a mechanical feed device sprays may cause irritation and bleeding.

In GB-A-408856 describes the input device, which in one method of use, apparently, gives the opportunity to submit two separate streams of air-entrained medication in the corresponding nasal cavity of a person. This input device has a camera with her sponge saturated drug, a mouthpiece connected to a camera, and the first and second terminals, connected to the camera. In one application of the device, insert the mouthpiece into the mouth of a person and tip in its respective nostrils, and exhaling through the mouthpiece separate streams of air entrained drug, forced into the nasal cavity the brow of the ESA.

However, it is unclear how this feeder could act properly in this kind of application, because, as is clear now, the uvula man closed when output through the mouth and, therefore, would overlap with the nasal airway, thereby preventing any substantial flow of air into the nasal cavity.

In WO-A-98/53869 described feed device for feeding powder containing drug to the nasal mucosa in one of the nasal cavities of humans. This device is a tube which contains a measured dose of powdered medication. When using the device the ends of the tube are placed respectively in one nostril of the nasal cavities and the mouth of man, and man through his mouth exhaled air entrains the powdered drug and supplies it to one nasal cavity, while the exhaled air goes back from one of the nostrils around the tube. In one variant embodiment of the invention the flexible tube contains the part before the dose of the powdered drug in the direction of flow. The presence of this flexible portion allows the person to block the tube in place prior to drug in the direction of flow, so that when you release blocked by the flexible part of the tube is about the time of expiration supplied short strong air flow in one nasal cavity. In another variant embodiment of the invention the end of the tube is placed in the nostril, may be attached to this form, to place the tube in place in the nostril permit the deposition of the powdered drug on the mucous membrane of the nose.

Although this feeder has a simple design, it does still not provide an effective supply of substances, in particular liquid or powder containing a drug to the posterior region of the nasal airway, as the drug is served separately in each of the nasal cavities and the flow of air into each nasal cavity and out of it passes through the same hole, namely the corresponding nostril, when closed, the rear region of the respective nasal cavity, acting as vozduhoohladitelnye surface, which causes a reverse flow of exhaled air from one nostril before when he any properly reaches the rear region of the respective nasal cavity. In addition, if short-lived, intense pulse of air flow into one of the nasal cavities, it is impossible to achieve long-term and controlled bidirectional flow of air through the nasal cavity, which, as established, it is necessary for the effective supply of the substance to the posterior nasal dyatel who's ways.

For effective flow of any substance into the nasal airway highly desirable effective and simple way of introducing substances. However, problems may occur when attempting this task, in particular pathological changes observed in the inflammation of the nose, complicate the introduction of substances, such as liquids or powders, particularly in the posterior region of the nasal Airways and to the rear edges of the nasal structures. Indeed, due to the complex configuration through with crack-like narrow channels in the nasal airway, these channels become partially clogged with inflammation and edema of the nasal mucosa, which complicates the distribution in the nasal airway of pharmaceutical products for local use.

Thus, the present invention is the creation of the conveying device and method to achieve more optimal distributed deposition matter, especially pharmaceutical preparations for topical application, in the nasal respiratory tract and, in particular, in the anterior region of the nasopharynx, where the adenoids and the bore of the pipe.

Therefore, according to the present invention offers a feed device for feeding the substance into the nasal airway of a person, containing a closing portion to permit closing rotor otocnog Palat, and supply part for supplying a gas flow, transporting substance in one of the nostrils of a person under such pressure that he passed around the posterior edge of the nasal septum and out the other nostril with the input portion includes a tip which includes a discharge tube through which the gas flow when using the device is in one nostril and a sealing element for sealing one of the nostrils relative to the discharge tube, so that when this device is used to prevent leakage of gas flow through one nostril.

In one variant embodiment of the invention the substance is a dry powder.

In another variant embodiment of the invention the substance is a liquid droplets.

The preferred particle size of the substance is generally in the range of about 1-10 microns.

In one variant embodiment of the invention, the substance includes a drug, in particular, for the treatment of diseases of the nose. In a preferred variant embodiment of the invention granulometric composition may include a smaller fraction with the larger particles, typically in the range of about 10-30 μm and preferably within about 20-30 microns.

In other embodiments, embodiments of the invention, the substance may be cleanser in the form of a powder or LM the bones for cleaning the nasal Airways or liquid for washing, which preferably may contain cleanser. The input device could be used, for example, for the introduction of saline or other solutions into the nasal airway to remove particles and discharge, and thus we get a solution could be subjected to analysis for diagnostic or research purposes. In a preferred variant embodiment of the invention granulometric composition cleansing or flushing means may include a fraction of the more than large particles, especially in connection with the mechanical action of these particles.

In addition, according to the present invention features a method of supplying a substance into the nasal airway of a person, containing the following stages: condense one nostril of the person relative to the discharge tube feeding parts to prevent leakage of the gas flow through one nostril, close the oropharyngeal velum of the curtain man and served the flow of gas entrained substance through the discharge tube under such pressure that he passed around the posterior edge of the nasal septum and out the other nostril of the person.

In one variant embodiment of the invention the closing Palat is achieved directly by using the tool for pressing Palat for its closure or stopper for temporarily closing hole is ment behind Palat between the nasal Airways and oral cavity.

In a preferred variant embodiment of the invention the closing Palat is achieved indirectly by creating a positive pressure in the oral cavity or the true positive differential pressure between the oral and nasal Airways, for example, achieved during exhalation.

Preferably, the soft palate was closed simultaneously with the start of supply of the substance into the nasal airway.

In a preferred variant embodiment of the invention the closing Palat is achieved automatically by the exhalation of a person to flow limiter, which can be functionally connected with a tube held between the lips. The flow limiter can be designed in such a way as to provide the necessary excess pressure in the mouth.

As established, a person can very easily provide a flow rate of about 1-20 l/min and, in particular, about 3-15 l/min, it is possible to maintain a fairly constant flow of air for up to 20 seconds depending on the volumetric flow rate. In some regimens, it is important for several seconds, preferably 3 to 10 seconds, to maintain a steady stream at a relatively high flow rate to ensure that the substance had the ability to penetrate the more remote h the security of the nasal Airways.

In one variant embodiment of the invention the flow of air exhaled by a person is used to actuate a mechanism that ensures the dispersion of substances in the air volume and flow of this dispersed substance into the nasal airway.

This mechanism preferably operates in such a way that the substance is fed into the nasal airway after closing Palat or simultaneously with the closing. In this respect, it is clear that bi-directional flow through the nasal cavity is only possible when closed soft palate, and it would be unfortunate if any substance submitted before the closing Palat, would be delivered to the lower respiratory tract or the alimentary canal.

Preferably, the selection of the substance into the nasal airway caused by the air flow generated during exhalation.

In a preferred variant embodiment of the invention uses a valve that responds to pressure and initiating the release of substances when you have a predefined volumetric flow rate. You must understand that the control of the volumetric flow rate of gas, which is a substance that is important, because this volumetric flow rate along with the granulometric composition of the material are important factors determining the mi the efficiency of deposition of particles.

In a preferred variant embodiment of the invention the valve that responds to pressure, not discovered until the person does not maintain a predetermined volumetric flow rate, and can be closed when the volumetric rate of flow falls below a predetermined value, thereby stopping the supply of the substance.

In a preferred variant embodiment of the invention, where the medicinal product is supplied in a carrying gas, to provide a standardized dosing carefully monitor one or both of the following: the time and duration of opening of the valve that responds to pressure, and the allocated dose.

In one variant embodiment of the invention, where the substance is released into the chamber and the gas flow and mixing of the metered dose of the substance is provided by the flow during exhalation, the flow of the gas stream may be extended for washing a strong jet nasal airway, when this extended washing does not affect the delivered dose. To ensure transporting gas can be used a mechanical device driven by compressed manually by spring, compressed air.

No matter which system can be optimized flow characteristics for improving the deposition of the substance and of the convenience factor, so as to avoid abrupt beginning, which, in the o f causes flexion reflexes.

Metered dose of the substance is preferred to provide in the feed chamber by means of a dosing device. This dosing device can be designed in such a way as to provide a gradual release of the active substances. This gradual release of the active substances will provide a better fascination substances by gas flow and thereby improve its supply all ventilated part of the nasal Airways, in particular, in the opposite nasal cavity.

In a preferred variant embodiment of the invention the air flow, which occurs when the exhalation man who velum closes the curtain, provides gas flow for Hobbies substances and create a bidirectional flow. This method is useful because you do not want to create a separate stream of carrier gas.

The tip is preferred to perform so that he was held approximately 1 cm in one nasal cavity to expand the valve area, i.e. the area located approximately 2-3 cm inside the nasal cavity and which is an area typically limit the flow, and to reduce the resistance, which can be large in case of inflammation of the nose.

The shape of the tip may be made in accordance with the specific requirements. For example, the internal shape of the tip can b shall be optimized to promote turbulence and achieve a more optimal dispersion of the substance.

The tip may contain tightly installed nasal olive, which can contribute to a physiologically suitable gas flow. Oliva can be removable, so you can install other olive with the same or different sizes. In the event of a severe blockage of nose nasal Oliva can be introduced into the other nostril to reduce resistance and facilitate flow through it.

As mentioned above, by means of the conveying device can easily be achieved flow of gas with a volumetric flow rate of at least 20 l/min Through the creation of a sufficiently large flow of gas substance can penetrate all or at least almost all parts of the complex nasal Airways. In one variant embodiment of the invention the input device may include a pointer that indicates the magnitude of the gas stream.

Dimensions reverse and holes behind the nasal septum is almost always greater than the dimensions of the orifice in the flow limiter. Thus, the pressure in the posterior region of the nasal airway closer to excessive pressure in the oral cavity and endangering the closing Palat only in very rare cases, complete blockage of the exhaust nostrils. In the event of a severe blockage of the insertion of the tip into the clogged nostril can reduce the resistance of obespechit able to successfully wash in a strong stream.

After successfully flushing a strong jet of nasal breathing through in one direction, you can repeat the same procedure in the other nostril. In this way wash out both of the nasal cavity in both directions. This is a unique feature of this unit. This variant embodiment of the invention provides improved distribution of matter in all parts of the mucous membrane of the nose and, in particular, in the rear region, which is difficult using current methods.

In a preferred variant embodiment of the invention, in which the substance is in solid form, as, for example, in powder form, you can then apply a filter if high humidity hinders the introduction of solids.

The substance may be a single compound or mixture of compounds, and the compounds may be in any suitable form, as for example in the form of a powder, solution or suspension.

You can use any suitable substance for introduction into the human or in some cases an animal. The substance can be approved for delivery and actions in any part of the nasal Airways or any of the surrounding tissues or organs. In addition, the substance may be intended for delivery and actions in the field, remote from the nasal respiratory tract.

Preferred substance is La delivery and follow-up in any part of the nasal Airways or any of the surrounding tissues or organs.

The substance may have beneficial health effects, which may be diagnostic effect, a therapeutic effect, a prophylactic effect and cleaning effect, as, for example, removal of particles, crusts, secretions, foreign substances, and so forth. Preferred substance having a therapeutic effect.

Preferred substance in the form of a pharmaceutical preparation. The pharmaceutical preparation may be mixed with any suitable carrier, diluent, excipient or adjuvant.

Preferred pharmaceutical preparation for the treatment of any one or more of the above diseases. For example, the pharmaceutical preparation can be used for the treatment of any allergic and non-allergic inflammatory diseases.

In a typical pharmaceutical preparations for admission include, but are not limited to, steroids, antihistamines, cromoglicate, antiallergic pharmaceutical drugs, anti-inflammatory pharmaceutical preparations antileukotriene, stimulants lactation, as, for example, oxytocin, and caused pharmaceuticals.

By providing a more optimal delivery of the feeding device according to the present invention improves the action of pharmaceutical preparations for topical application in the treatment of pathologies of the top respiratory tract, for example, hypertrophic adenoids and chronic secretory otitis media.

In addition to the supply of pharmaceutical products, the device can also be used for washing or cleaning of the nasal Airways saline or other solutions, preferably containing oils or herbs.

The device according to the present invention can be carried out in accordance with specific needs. For example, it can easily be provided with beads or emerging figures for the semi-quantitative indication about the volumetric flow rate and to improve the acceptability and ease of injection drugs in young children.

Insufflate would be compromised only in rare cases, when the resistance of the nose would be too large and did not allow gas flow through the nasal respiratory tract even after attempts to expand the nasal cavity. In these cases, you may need pre-treatment with antineoplastic agents.

The input device can also be used as a means for rinsing the nose when collecting mediators and cells derived from the mucous membrane of the nose, for example, diagnostic analysis or research purposes. In this respect, the mediators and cells can be disposed of in an appropriate collection after the nasal dehat the global path subjected to the action of the corresponding solution, as, for example, saline solution, for a sufficient period of time to ensure sufficient transfer of mediators and cells in solution. This use of the device may require the use of gas flow separately from the flow of exhaled air as a stream for washing a strong jet nasal airway. For this purpose, the washing may not be able to use the exhaled air, as the lower respiratory tract may contain mediators, separation and cells originating from the lower respiratory tract, which would defile the sample from the nose. As mentioned, in this particular case the application of the liquid emitted from the exhaust of the nostrils, can be collected in the collection. On the other hand, the liquid oozing out of the outlet of the nostrils, can be absorbed in the filter for the immediate or delayed analysis. Indeed, such filters and similar tools can even give the possibility of almost immediate detection of specific organisms, such as bacteria, viruses or mediators.

The input device according to the present invention is useful for a number of reasons.

It is noteworthy that the input device is a very simple and effective means for supplying substances, such as pharmaceuticals, salt solutions and the like in the nose of the new respiratory tract. In this regard, the device has a very simple design with few moving parts, making it relatively inexpensive for mass production. In addition, the device according to the present invention can be performed for a single use, eliminating thus the need to introduce any preservatives to deliver a substance.

In addition, the present invention eliminates the need for subsequent ways of washing a strong jet or spray, which are associated with some of the devices known from the prior art. However, in some cases, applications may still be desirable subsequent washing operation in a strong jet or spray.

The input device according to the present invention is useful because when using it tight seal between the tip and one nostril provides even greater penetration in complex nasal Airways, bi-directional flow of gas through the nasal cavity and the deposition of substances in the opposite nose.

According to the present invention will normally be kept closed position Palat. The feed gas stream enters the one nasal cavity, passes over the rear edge of the nasal septum, makes a 180° behind the posterior edge of the nasal septum and vigodarzere the other nasal cavity. This change of direction of the gas flow leads to a better deposition of substances, especially of pharmaceutical preparations in the posterior regions of the nasal Concha and the nasal mucosa.

In addition, bi-directional deposition of substances, usually of pharmaceutical preparations and washing will be better to go to all the openings of the sinuses due to anatomical location and orientation of the openings of the sinuses, which can improve ventilation and drainage of the sinuses, which are important in the treatment of sinusitis is often accompanied by inflammation of the mucous membrane of the nose. By the way, vents and pipes to the sinuses, ethmoid and sphenoid sinuses are located in the posterior region of the nasal airway, and hooked tabs, closing the funnel, with the maxillary, frontal and front openings of the ethmoid bone, tilted back. Also used to feed the excess pressure will increase the deposition of pharmaceuticals in the openings of the sinuses, the tubes of the sinuses, leading to sinus, and even in the sinuses.

In addition, changes in flow direction by 180° behind the nasal septum especially increases the deposition of the substance on the top wall of the nasopharynx, where the adenoids, and near the location of the holes in the auditory tube connects the nasopharynx and the middle ear. For example, steroids,as shown, reduce the size of the hypertrophic adenoid commonly found in children, and can have a positive effect on the sector otitis. Deposition-inflammatory drugs for local application closer to the pipes also can more efficiently eliminate swelling in the ear tubes and remove the negative pressure in the middle ear, which is accompanied by rhinitis, and which predisposes children to sector otitis media and as a result to reduced hearing. Children often spend surgery for enlarged adenoids, and improved drug therapy according to the present invention should reduce the need for surgery.

Another advantage is that the possible excess substance, i.e. a substance which is not deposited, will be deleted from the opposite nostril, where it is optionally possible to collect, and, consequently, will not pass to the mouth and down into the digestive canal, as is the case with many other ways of presenting material. Thus, we will reduce the inconvenience and, more importantly, the undesirable effects of substances on the entire body, when the substance is a drug.

In addition, because the present invention can more efficiently and with fewer perelivaniami and inconvenience to saline lavage or others is in other solutions, than when modern methods of rinsing the nasal airway in the usual manner and by a strong jet.

Further, the present invention provides a simple and convenient washing of the nasal mucosa solutions, such as saline solutions, and oils to remove the secretions from the mucous membranes and facilitate the function of ciliated epithelium.

Moreover, the present invention provides a simple and effective means for lavage of the nasal mucosa, to collect and to recognize such forms of mucous membrane, such as bacteria, viruses, components of cells and inflammatory mediators.

Moreover, the impact of excessive pressure on the mucous membrane of the nose, especially the dynamic pressure, will result in the disclosure of narrow - and sometimes occluded parts of the nasal passages, and not to the dynamic flattening, which can happen when inhaling through the nose and inhalation. Dynamic overpressure is at least 5 cm of water. Art., preferably at least 50 cm of water. Art., preferably at least 100 cm water. senior, more preferably at least 200 cm of water. senior, more preferably, 400 cm water. Art. and more preferably 500 cm of water. senior Dynamic overpressure achieved by the present invention can be prot is sopostavleno static pressure, created when the method of Valsalva, in which there is no flow through the nasal Airways.

In addition, the use of warm and moist air as the gas flow is probably easier to understand and causes less irritation than room air or outside air, especially in cold climates.

If the substance is a dry powder, then the humidity of the exhaled air in some cases can lead to caking of the powder. Of course, this will depend on the properties of the powder and the design of the device, in particular the dispersion chamber. To mitigate this particular problem, you could change the surface properties of the powder or you can type in the device water-absorbing element, usually containing a desiccant, such as silica, and located in front of the camera dispersion in the direction of flow. In a preferred variant embodiment of the invention water-absorbing element could be provided with a filter, which acts as a flow limiter.

In a preferred variant embodiment of the invention to ensure that the adhesion of the powder will not interfere with the direct injection of warm, moist exhaled air, the feed device comprises a transporting means, which produces a stream of dry air is, for example, atmospheric air as a stream for feeding the substance into the nasal airway. Such transporting means, which by their nature can be mechanical, uses the energy of exhaled air in order if necessary to pump atmospheric room air with the necessary bulk velocity dispersion of the substance in the feed air stream. In this variant of embodiment of the invention, the adhesion would be prevented or at least reduced to the same level that currently takes place in inhalers for inhalation powders.

It was possible, using standard methods, to investigate the distribution of substances lodged in the nasal respiratory tract. For example, you could use acoustic rhinometry or colored liquid. Distribution filed substances could even be determined by videoendoscopy. In addition or alternatively, studies on the distribution of matter was also performed using radioactive substances and tracing their passage in the nasal cavity. The results of these studies could be used to optimize the volumetric flow rate, the shape or dimensions of the device, in particular the form of the tip, and granulometric composition of matter. The results of the Pacific research could even be used for optimization of human perception.

As already mentioned, the input device may contain ball or similar showing the device for indications that the desired excess pressure, with ball or showing the device can improve the acceptability of the feeding device for young children who are reluctant to use it.

On the other hand, in very young children the gas flow entrained substance can be formed by exhalation air flow by another person such as a parent, or even by using a pump and the like, while the child creates the necessary excess pressure in the oral cavity, inflating the ball or indicating device.

Now just as an example will be described below, the preferred variants of the embodiment of the present invention with reference to the accompanying drawings, in which:

figure 1 schematically illustrates the anatomy of the upper respiratory tract of man,

figure 2 schematically illustrates the input device according to the first variant embodiment of the present invention,

figure 3 schematically illustrates the input device according to the second variant embodiment of the present invention,

figure 4 schematically illustrates the input device according to the third variant embodiment of the present invention,

figure 5 schematically illyustririrovannyy supply part to the above-described first third variants of the embodiment of the present invention,

6 schematically illustrates the input device according to the fourth variant embodiment of the present invention,

7 schematically illustrates the input device according to the fifth variant embodiment of the present invention,

Fig schematically illustrates the input device according to the sixth variant embodiment of the present invention, and

figure 9 schematically illustrates the input device according to a seventh variant embodiment of the present invention.

Figure 2 illustrates the input device according to the first variant embodiment of the present invention.

The input device includes a portion 20 to exhale from the mouth and part 22 for feeding substances. In this variant embodiment of the invention, the part 20 to exhale from the mouth and part 22 for feeding the substance is made as a separate part, but, on the other hand. they could be Rethimno connected, for example by fasteners "Welkom" /trademark/attached, for example, by means of screws and/or rivets, or even formed in one piece.

Part 20 to exhale from the mouth contains a tube 24 and mouthpiece 26 attached to one end of the tube 24. The mouthpiece 26, which, when used, gripped in the lips of the user, is formed separately from the tube 24 to the possibility of its replacement, what about on the other hand, it could be made in one piece with it. In this variant embodiment of the invention the mouthpiece 26 with snap's on top of the tube 24, but it equally could be screwed to it. Tube 24 contains a limiter 28 thread, which in this variant embodiment of the invention made in the form of fixed partitions, providing sufficient resistance to the exhalation of a person through it to create a positive pressure in the oral cavity of the person and closing Palat under his breath. In other embodiments, embodiments of the invention, the flow limiter 28 could be made in the form of a rolling element, such as, for example, shifted sash, elastic membrane or braked wheel.

The input part 22 includes a tip 30, which in this variant embodiment of the invention is formed from an elastic material, for example polymeric material, to provide a snug tight insertion into one of the nostrils of man; part 32 for the supply of a medicinal product into the stream of gas entrained drug and entered into one of the nasal cavities of a person under a predetermined pressure sufficient to open the flow path behind the rear edge of the nasal septum; the tube 34 connecting the tip 30 and the portion 32 to supply medicines. In a preferred variant embodiment of the invention, the tip 30 m which may contain external olive or be executed in such form, to expand the anterior region of the nasal cavity when inserted into it. In a particularly preferred variant of embodiment of the invention, the tip 30 can be attached to the form, for example, swirl the tabs to ensure optimum exhaust gas and the distribution of particle size. The tip 30 is made separately from the tube 34 to the possibility of its replacement, but he, on the other hand, could be formed in one piece with it. In this variant embodiment of the invention, the tip 30 with snap's on top of the tube 34, but it equally could be screwed to it. Part 32 for supply of medicines may be an aerosol dispenser for education aerosol jet of liquid droplets containing the drug, as, for example, is equipped with a nebulizer for supplying removable dose under pressure or compressed gas source for Hobbies metered dose of dry powder containing a drug and loaded in it, while the powder, on the other hand, could be loaded into a cell in the tube 34.

When using the device clamped lips to the mouthpiece 26 and insert the tip 30 into one of the nostrils. Then produce exhalation through the mouthpiece 26, the flow of exhaled air resists the stopper 28 of the flow in the tube 24, so that was created from ydachnoe pressure in the oral cavity of the person for the formation of pressure drop through the velum curtain, sufficient for its closing. As established by the applicant, to maintain Palat in closed position required positive pressure difference between oral and nasal Airways, equal to about 5 cm Vogt the Applicant also determined that the person must be capable of maintaining a flow rate of about 3-30 l/min for about 1-20 C, while the optimum is considered the volumetric flow rate of about 10-20 l/min and the duration of flow of gas about 2-5 C. After closing Palat then driven part 32 for supplying medicines carried by a stream of gas through the tip 30 and into the nasal airway man. As mentioned above, this gas stream is fed under pressure to open the path message behind the rear edge of the nasal septum, so that the gas stream passes through one nasal cavity, around the posterior edge of the nasal septum, in fact, changing the direction at an angle of 180°and out of the other nasal cavity. In addition, as already described, this bi-directional flow provides much better deposition of the drug in the posterior region of the nasal Airways.

In one embodiment, in the input part 22 may be missing part 32 for supplying drugs but instead I had a side in the tube 34 is placed a measured dose of dry powder, and the flow of the feed air is created by another person, such as a parent of a child who is blowing into the distal end of the tube 34.

Figure 3 illustrates the input device according to the second variant embodiment of the present invention.

The input device includes a portion 20 to exhale from the mouth and the input part 22 of the above-described first variant embodiment of the invention, as well as the final part 36 for installation in the arch of the nostril of the person who set the input part 22.

The outlet portion 36 includes a tube 38 and the tip 40, which in this variant embodiment of the invention is formed from an elastic material, such as polymeric material, and is attached to one end of the tube 38 to provide a tight sealed is inserted into the other nostril of the person. The tip 40 is made separately from the tube 38 for his replacement, but he, on the other hand, could be formed in one piece with it. In this variant embodiment of the invention, the tip 40 with snap's on top of the tube 38, but it equally could be screwed to it. As the tip 30 of the feeding part 22, the tip 40 in a preferred variant embodiment of the invention may contain external olive or be made of such form that when inserted in the front area of the other bow to expand it. Tube 38 contains a flow limiter, the cat is who in this variant embodiment of the invention is a wall form, providing sufficient hydraulic resistance to the flow of exhaled through her, to create a dynamic excess pressure in the nasal airway. In a preferred variant embodiment of the invention, the stopper 41 of the flow is made adjustable to adjust the level of resistance and, therefore, control of dynamic pressure in the nasal airway. In other embodiments, embodiments of the invention, the stopper 41 of the flow could be in the form of a rolling element, such as, for example, shifted sash, elastic membrane for a braked wheel.

In a preferred variant embodiment of the invention the outlet portion 36 contains a pointer to supply at least one video signal or audio signal to achieve a predetermined excess pressure before him, i.e. in the nasal airway. The pointer is preferably in the form of a whistle. Thus, the person has positive feedback, demonstrating correct use of the device.

The input device according to this variant embodiment of the invention is used the same way as the input device according to the above described first alternative embodiment of the invention. However, as mentioned above, due to the presence of constraints is of Italia 41 flow into the exhaust portion 36 after graduation nostrils of a person supported in excessive dynamic pressure in the nasal airway. This excess pressure has a beneficial effect, expanding the various openings of the nasal airway, as, for example, holes, cavities and holes in the pipes, and associated pipes, such as pipes sinuses and the auditory tube, which helps feed them drugs. In addition, under the action of this pressure improves the deposition on the adenoids, which part may clog the openings of the pipes, in the middle passage, which is the usual location of nasal polyps, and in cracks to the olfactory cells.

Figure 4 illustrates the input device according to the third variant embodiment of the present invention.

This feeder is very similar to the feeding device according to the above-described second variant embodiment of the invention, and, therefore, to avoid needless repetition of description, will be described in detail only the differences, with similar parts indicated by the same positions. This feed device differs only in that it further contains the sensor 43 pressure, which in this variant embodiment of the invention made in the form of a pressure-sensitive spring or membrane located in the tube 34 of the feeding device 22 after part 32 for supply of medicines, and the block 44 control connected to the sensor 43 and part 32 for supplying the medicament is military means.

The block 44 is a control with adjustable volume flow rate of feed gas fed part 32 for supply of medicines, in order to optimize the efficiency of deposition of particles in the nasal airway irrespective of the degree of blockage of the nose. As mentioned above, by maintaining the optimum flow rate in the nasal airway increases the efficiency of deposition of particles containing the drug, called efficiency of sediment particles. If to maximize the efficiency of deposition of particles is usually required volume flow rate of about 15 l/min, then blocked nasal airway would require a smaller volume flow rate of perhaps 10 l/min, and when open the nasal airway higher volumetric flow rate, may 20 l/min

The principle of operation of this feeding device otherwise is the same as that of the conveying device according to the above-described second variant embodiment of the invention.

Figure 5 illustrates a modified portion 20 to exhale from the mouth in a feed device according to the above-described variants of the embodiment of the invention.

This modified part 20 to exhale from the mouth characterized in that the tube 24 includes side from Erste 45 before the limiter 28 to flow in the direction of flow and, in addition, it contains as a pointer inflatable figure 46, is connected with a lateral hole 45 and when inflated receiving pre-eminent position in the field of human rights. Figure 4 figure 46 shows pressurized. Thanks to the use of such a display should improve the receptivity of the person, especially children, to the device. Part 20 to exhale from the mouth, in addition, contains the discharge tube 48 connected to the figure 46 and allowing further inflate the figure 46 another person, usually a parent of the child, or pump. In another variant embodiment of the invention, instead of the inflated figures could be applied to the shape of any type that takes a protruding position when the exhalation person, usually mechanically or electrically, the current figure. In a preferred variant embodiment of the invention figure 46 can be made to inflate when the optimal flow rate of the exhaled flow. Thus, figure 46 acts as a pointer.

The input device according to this variant embodiment of the invention is used the same way as the input device according to the above described first alternative embodiment of the invention. However, when exhaling through the mouthpiece 26 created pressure causes inflation figures 46 and acceptance of a speaker's position in the e view. It is the emergence of figure 46 is particularly attractive to children as a comic element inherent inflation figures 46, may mitigate any unnecessary fear.

6 illustrates the input device according to the fourth variant embodiment of the invention.

The input device includes a camera 50, which has an inlet 52 and outlet 54, the mouthpiece 56 connected to the inlet hole 52, and the tip 58 connected to the outlet 54. The tip 58 is configured to tight sealed insertion into one of the nostrils of man. The camera 50 includes a limiter 60 flow, which in this variant embodiment of the invention made in the form of multiple partitions and compartment 62 for the reception of medicines, which is located after the limiter 60 flow in the direction of flow and is used to place a measured dose of a dry powder containing a drug and intended for submission to the nasal airway of the person. In this variant embodiment of the invention, the tip 58 is formed from an elastic material, such as polymeric material. In a preferred variant embodiment of the invention, the camera 50 may contain a desiccant. In a preferred variant embodiment of the invention, the limiter 60 flow can be equipped with a water-absorbing filter.

When is ispolzovanie device clamped lips mouthpiece 56 and insert the tip 58 in one nostril. Then produce exhalation through the mouthpiece 56, the flow of exhaled air resist limiter 60 flow in the chamber 50 and nasal Airways, so that an excessive pressure in the oral cavity of the person, sufficient for closing Palat. After passing through the limiter 60 of the flow of exhaled air then carries the powdered drug in the chamber 62 for the reception of medicines, and this air flow carries away the drug, then passes through the tip 58 into the nasal airway of the person. The exhaled air is introduced into the nasal airway pressure sufficient to open the lines of communication behind the rear edge of the nasal septum, so that the air flow passes through one nasal cavity, around the posterior edge of the nasal septum, in fact, changing the direction at an angle of 180°and out of the other nasal cavity. In addition, as already described, this bi-directional flow provides much better deposition of the drug in the posterior region of the nasal Airways.

In a preferred variant embodiment of the invention the input device comprises a trigger pressure valve, which preferably is located at the tip 56 and is made to open only when the exhalation people the century creates a predetermined excess pressure, usually at a pressure of about 10 cm vods This design helps to avoid supply of drugs in nasal airway when Palat in open position and, thus, reduces the risk of unwanted deposition of the medicinal product outside of the nasal Airways.

In another preferred variant of embodiment of the invention the input device like the feed device described according to a third variant embodiment of the invention may contain an exhaust part for use of the flow limiter after the other nostril of the person to maintain excessive dynamic pressure in the nasal airway.

Fig.7 illustrates the input device according to the fifth variant embodiment of the present invention.

The input device includes a portion 70 to exhale from the mouth, through which the person breathes out to close his Palat, and part 72 for supplying drugs for which the drug is carried by a stream of air is fed into the nasal airway of the person.

Part 70 to exhale from the mouth contains a tube 74 and the mouthpiece 76 attached to one end of the tube 74. The mouthpiece 76, which is clamped lips formed separately from the tube 74 to the possibility of its replacement, but with the pile, it could be made in one piece with it. In this variant embodiment of the invention the mouthpiece 76 snap's on top of the tube 74, but it equally could be screwed to it. Tube 74 includes a limiter 78 flow, which in this variant embodiment of the invention made in the form of a gear wheel for rotation with the exhalation of a person and also create sufficient resistance to the exhaled flow for the formation of a positive pressure in the oral cavity of the person, sufficient to maintain the required positive pressure differential between the oral and nasal Airways and thereby maintain Palat in closed position.

The input part 72 includes a tube 80 and the tip 82, which in this variant embodiment of the invention is formed from an elastic material, such as polymeric material, to provide a snug air-tight insertion into one of the nostrils of a person and attached to one end of the tube 80. The tip 82 is formed separately from the tube 80 to the possibility of its replacement, but, on the other hand, it could be made in one piece with it. In this variant embodiment of the invention, the tip 82 with snap's on top of the tube 80, but it equally could be screwed to it. In a preferred variant embodiment of the invention, the tip 82 can contain naru is strong olive or be executed in such form, to expand the anterior region of the nasal cavity when inserted into it. In a particularly preferred variant of embodiment of the invention, the tip 82 can be attached to the form, for example, swirl the tabs to ensure optimum exhaust air and the distribution of particle size. Tube 80 comprises a gear wheel 84 which is connected to a toothed wheel 78 in the tube 74 part 70 to exhale from the mouth and rotating with the rotation of the gear wheel 73 for drawing air into the tube 80 and create air flow through it under pressure sufficient to open the lines of communication behind the rear edge of the nasal septum when the flow of air into one of the nasal cavities of a human.

The input part 72, in addition, contains the dispenser 86 for issuing a metered dose of dry powder containing a drug, the tube 90 when the toothed wheel 84 in the direction of flow. In this variant embodiment of the invention the dispenser 86 is actuated manually to supply metered dose of dry powder containing a drug, the tube 80, but, on the other hand, it can be made to drive the toothed wheel 78 to avoid the need for any manual intervention on the part of the person.

When using the device clamped lips mouthpiece 76 and insert n is konecnik 82 in one nostril. Then produce exhalation through the mouthpiece 76, the flow of exhaled air has a resistance sprocket wheel 78, so as to create excess pressure in the oral cavity of the person, sufficient to cover its Palat. The exhaled air causes rotation of the toothed wheel 78, which, in turn, causes the rotating sprocket wheel 84, and when the rotation of the gear wheel 84 creates a flow of air through the tube 80, which carries metered dose of a dry powder containing a drug, and delivers it through the tip 82 into the nasal airway of the person. As mentioned above, this flow of air is supplied under sufficient pressure to open the lines of communication behind the rear edge of the nasal septum, so that the air flow passes through one nasal cavity, around the posterior edge of the nasal septum, in fact, changing the direction at an angle of 180°and out of the other nasal cavity. In addition, as already described, this bi-directional flow provides much better deposition of the drug in the posterior region of the nasal cavity.

In a preferred variant embodiment of the invention the toothed wheel 78 is designed in such a way as to prevent its rotation until then, until it reaches the preset volumetric flow rate, which is I sufficient for optimal entrained gas flow, created a toothed wheel 84. This design successfully provides optimal deposition efficiency of particles and eliminates the possibility of drug in the nasal airway when Palat in the open position, thereby reducing the risk of unwanted deposition of the medicinal product outside of the nasal Airways.

Fig illustrates the input device according to the sixth variant embodiment of the invention.

The input device includes a housing 90 for placing blister packing element 92, which includes many blister cells 94 finding each powder containing a drug and a tube 96 is in communication with one of the blister cells 94, when it is open, with one end of the tube 96 is equipped with a mouthpiece 98, which when using clamped lips. Tube 96 contains an element 100, movably located therein between the first normally closed position and a second, normally open position. In this variant embodiment of the invention, the element 100 is made in the form of an impeller mounted for rotation on the threaded shaft and normally biased to a closed position by a compression spring. The element 100 is made to act as a flow limiter and valve. This variations is the embodiment of the invention, the element 100 is made to move against the resistance of compression spring to an open position, where the released drug, due to its rotation on the threaded shaft, and the powder can be carried away by the flow of air only when it exceeded a preset volume flow rate of the exhaled air. The volume flow rate of air, preferably approximately 5 to 20 l/min, at which powder containing a drug is entrapped in the air stream is a function, inverse relation, the discharge pressure, which itself is a function of the resistance of the nose, as described above. It is clear that this construction has been providing the optimum deposition efficiency of particles in releasing the powder containing the drug, at the optimum flow rate and eliminates the possibility of drug in the nasal airway when Palat in open position.

The input device also includes a handpiece 102, which in this variant embodiment of the invention is formed from an elastic material, such as polymeric material, to provide a snug tight insertion into one of the nostrils of a person and attached to the tube 96 after the element 100 in the direction of flow. The tip 102 is formed separately from the tube 96 to the possibility of its replacement, but on the other hundred is ony, it could be made in one piece with it. In this variant embodiment of the invention, the tip 102 with snap's on top of the tube 96, but it equally could be screwed to it. In a preferred variant embodiment of the invention, the tip 102 may include an outer Oliva or to be made with this form, to expand the anterior region of the nasal cavity when inserted into it. In a particularly preferred variant of embodiment of the invention, the tip 102 may be attached to the form, for example, swirl the tabs to ensure optimum exhaust air and the distribution of particles by size.

The input device also includes a mechanism 104 for opening blister cell 94 in communication with the tube 96. In this variant embodiment of the invention, the mechanism 104 for opening blachernai cell is driven by a person manually before serving.

When using the device clamped lips mouthpiece 98 and insert the tip 102 in one nostril. Then produce exhalation through the mouthpiece 98, the flow of exhaled air has a resistance element 100 until it reaches the preset volumetric flow rate. After achieving this preset volumetric flow rate, the uvula is in the closed position, and the element 100 is in the open position, and the flow of exhaled air entrains the powdered drug in blister cell 94 and delivers it through the tip 102 to the nasal airway. The discharge pressure of this air flow is at a level sufficient to maintain the lines of communication behind the rear edge of the nasal septum, so that the air flow passes through one nasal cavity, around the posterior edge of the nasal septum, in fact, changing the direction at an angle of 180°and out of the other nasal cavity. In addition, as already described, this bi-directional flow provides much better deposition of the drug in the posterior region of the nasal Airways.

In a preferred variant embodiment of the invention the input device includes a mechanism for moving the blister pack, which is driven by the movement of the mouthpiece 98 for rotation blister packing element 92, so that the unused blister cell 94 located in the feeding position. In a particularly preferred variant of embodiment of the invention, the mechanism for moving the blister pack can be connected to the opening mechanism of blister cells 104 to, for example, to automatically open the blister cell 94 and thereby eliminate the need for any additional human intervention.

Water modification device, similar to the above modification according to the first variant embodiment of the invention shown in figure 3, the input device may contain the final part with the arrangement of the flow limiter after the other nostril of the person in the direction of flow to maintain the positive dynamic pressure in the nasal airway.

In another modification blister packing element 92 may be omitted, and the housing 90 instead provided with a chamber which is in communication with the tube 96 and into which can be placed metered dose of dry powder containing a drug. With this design the powder in the chamber is keen on the element 100 is moved to the second position, and mechanism for moving the blister pack is made to supply the dose of powder containing a drug in the camera while it is in operation.

It is clear that essentially the present invention may be applicable to any inhaler for dry powder, as for example, "Turbuhaler" /trademark/, manufactured "As-TRASECA PLC", "Accuhaler" /trademark/, manufactured "Glaxo PLC", or "Twisthaler" /trademark/, manufactured "Schering AG", where the usual mouthpiece replace the tip, and the tip is brought into communication with the intake air into the inhaler, so that usage is to use the air, exhaled as enthralling supplied air.

Figure 9 shows the input device according to a seventh variant embodiment of the present invention.

The input device includes a housing 110 and the receiver 112, which passes through the housing 110, and one end of which forms the mouthpiece 114, when using the compressed lips of the person.

Tube 112 contains the element 116, movably mounted therein between a first normally closed position and the second involving the position. In this variant embodiment of the invention, the element 116 is made in the form of an impeller mounted for rotation on the threaded shaft and normally biased to a closed position by a compression spring. The element 116 is made to act as a flow limiter valve and switch for supplying aerosol flow tube 112, as will be described in detail below. In this variant embodiment of the invention, the element 116 is made to move against the resistance of compression spring to an open position, where the released drug, due to its rotation on the threaded shaft only when it exceeded a predefined volumetric rate of the exhaled flow. The volumetric flow rate at which the released drug, preferably within about the olo 5-20 l/min, is a function, inverse relationship, discharge pressure, which itself is a function of the resistance of the nose, as described above. It is clear that this construction has been providing the optimum efficiency of the distribution of particles by size at release of drug at the optimal flow rate and eliminates the possibility of drug in the nasal airway when Palat in open position.

Tube 112, in addition, contains a nozzle 117 to generate the aerosol stream through a tube 112 along its longitudinal axis. As will be described in detail below, the nozzle 117 is part of the stem 122 of the valve of the aerosol container 120.

The input device also contains a known aerosol container 120 that is used to supply metered amounts of propellant, preferably hydrofluroalkane /GFA/ or the like containing a medicinal agent in the form or suspension, or solution. The aerosol container 120 has a main body 121, in which the pressure is a certain amount of propellant containing the drug, the stem 122 of the valve, through which, during use of the device propellant containing drug, is served by relative movement of the main body 121 and shaft 122 of the valve and the metering valve 124 d is I dispensing a predetermined volume of the propellant, containing drug to the shaft 122 of the valve when it is moved.

The input device also includes a mechanism 126 enable a relative movement of the main body 121 and shaft 122 of the valve of the aerosol container to effect the filing of a measured amount of propellant containing pharmaceutical agent through the nozzle 117. In this variant embodiment of the invention the mechanism 126 inclusion contains elastic element 128 for application to the main body 121 of the acting force, and lever system 130 that is connected with the movable element 116 to release the acting force generated by the elastic element 128, to move the moving element 116 from the closed position in the enclosing position.

The input device also includes a tip 132, which in this variant embodiment of the invention is formed from an elastic material, such as polymeric material, to provide a snug tight insertion into one of the nostrils of a person and attached to the other end of the tube 112 after rolling element 116 in the direction of flow. The tip 132 is formed separately from the tube 112 to the possibility of its replacement, but, on the other hand, it could be made in one piece with it. In this variant embodiment of the invention, the tip 132 with snap's on top of the tube 112, but it is equally and could be screwed to it. In a preferred variant embodiment of the invention, the tip 132 may contain external olive or be executed in such form, in order to expand the anterior region of the nasal cavity when inserted into it. In a particularly preferred variant of embodiment of the invention, the tip 132 may be attached to the form, for example, swirl the tabs to ensure optimum exhaust air and the distribution of particles by size.

When using the device vzvoda mechanism 126 include, clamp the mouthpiece 114 in the lips and insert the tip 132 in one nostril. Then produce exhalation through the mouthpiece 114, and the flow of exhaled air resists the movable element 116 until then, until it reaches the preset volumetric flow rate. Once achieved this preset volumetric flow rate, the uvula is in the closed position, and the movable element 116 is in the open position, causing the movement of the lever system 130 and, therefore, relative movement of the main body 121 and shaft 122 of the valve cylinder 120 for supplying a measured amount of propellant containing pharmaceutical agent to the nozzle 117 for education aerosol jet of liquid droplets containing the drug, through the tip 132 to nasal respiration is considerable ways. This aerosol flow is under pressure sufficient to maintain the lines of communication behind the rear edge of the nasal septum, so that the flow passes through one nasal cavity, around the posterior edge of the nasal septum, in fact, changing the direction at an angle of 180°and out of the other nasal cavity. In addition, as already described, this bi-directional flow provides much better deposition of the drug in the posterior region of the nasal Airways.

It is clear that, in essence, the present invention can be equally applicable in any nebulizer for supplying metered dose under pressure through exhalation, where the usual mouthpiece replace the tip, and the tip is brought into communication with the intake air into the inhaler, for example, how to start the mechanism of inclusion and use of air exhaled by a person, as entrained air supply.

Finally, it is clear that the present invention is described in its preferred embodiments, embodiments and can be modified in many different ways without leaving the scope of the invention as defined in the attached claims.

1. Nasal feeding device for feeding the substance into the nasal airway of a person, containing a closing portion to permit closing retopo the full-time Palat man and a feeding portion for feeding the substance into one of the nostrils of man, in which the input part includes a handpiece that includes a discharge tube for supplying substances when using the device in one nostril and a sealing element for providing impervious to the fluid seal between the exhaust pipe and one of the nostrils.

2. The input device according to claim 1, in which the closing part includes a mouthpiece through which exhales people while using the device, and the flow limiter connected to the mouthpiece to ensure that the hydraulic resistance to the flow of exhaled air.

3. The input device according to claim 2, in which the flow limiter is made to ensure the limits with the possibility of using the keep when you exhale the person a positive pressure differential of at least about 5 cm Vogt between places before and after the flow limiter in the direction of flow.

4. The input device according to any one of claims 1 to 3, in which the input part, in addition, contains the input channel connected to the tip and is made for receiving substances to be fed through one nostril.

5. The input device according to any one of claims 1 to 3, in which the input part, in addition, contains a supply part for supplying a flow of gas entrained substance to the tip.

6. The input device according to claim 5, in which the inlet part is made with the possibility of the filing of the gas stream separately from the exhaled flow.

7. The input device according to claim 5 or 6, in addition, contains a control unit to control the supply part for regulating the volumetric rate of the supplied gas stream.

8. The input device according to claim 1, in which the closing part includes a mouthpiece and a movable element, made for movement through the mouthpiece when you exhale man, and the input portion, in addition, contains the input channel connected to the tip and is made for receiving substances to be fed through one nostril, and the impeller, functionally connected with the movable element so that when used to travel with him and to create a flow of gas through the feed channel for Hobbies substances.

9. The input device of claim 8, in which the movable element is designed as a flow limiter to provide hydraulic resistance to the flow of exhaled air.

10. The input device according to claim 9, in which the movable element is made to ensure the restrictions, with the possibility of using the keep before him in the direction of flow during exhalation person excess pressure of at least about 10 cm Vogt

11. The input device according to any one of p-10, in which the movable element is designed as a rotating element.

12. The input device according to any one of p-11, in addition, contains a dispenser for dispensing doses of veshestva input channel.

13. The input device of claim 1, wherein the input part includes a mouthpiece and a channel connecting the mouthpiece with a tip, when this channel is made for the reception of the supplied substances through the tip when exhaling through the mouthpiece.

14. The input device according to any one of claims 1 to 13, in which the input part further contains including the mechanism for actuating the feeding part in response to exhalation by the person.

15. The input device according to any one of claims 1 to 14, in which the feeding part configured to feed gas flow entrained substance in one nostril.

16. The input device 15, which supply part configured to supply gas under pressure to cause flow of gas around the posterior edge of the nasal septum and out the other nostril of the person.

17. The input device according to item 15 or 16, in addition, contains the final part containing tip for insertion into the other nostril and the flow limiter to provide hydraulic resistance to the flow of gas coming out the other nostril to maintain a positive dynamic pressure in front of him in the direction of flow.

18. The input device 17, in which the flow limiter exhaust parts are made adjustable to regulate the hydraulic pressure.

19. The input device 17 or 18, in which oterom outlet portion, in addition, contains a pointer to supply at least one video signal or audio signal that indicates the achievement of at least one of the predetermined volumetric flow rate or pressure before him in the direction of flow.

20. The input device according to any one of claims 1 to 19, in which the input part, in addition, contains a pointer to supply at least one of video or sound when exhaling through the mouthpiece.

21. The input device according to claim 20, in which the pointer contains the indication, which appears in mind when you exhale through the mouthpiece.

22. The input device according to any one of claims 1 to 21, containing the feed substance.

23. The input device according to any one of claims 1 to 22, in which the substances used one or more of the medicines, cleaning agents for cleaning the nasal Airways or flushing means for flushing the nasal Airways.

24. The method of delivery of the substance into the nasal airway of a person, which provide a feeding device for feeding the substance containing the discharge tube, through which substance is delivered into the nasal airway, condense one of the nostrils of a man impervious to the fluid way relative to the discharge tube feeding part, for the current oropharyngeal velum curtain man, and serves the substance through the discharge tube in one nostril.

25. The method according to paragraph 24, in which the stage of closing Palat carried out through exhalation of the person.

26. The method according A.25, in which the exhalation through the flow limiter to maintain a positive pressure differential between the oral and nasal Airways of a person, sufficient to maintain Palat in closed position.

27. The method according to p, in which the flow limiter is performed to maintain a positive pressure differential of at least about 5 cm Vogt between oral and nasal Airways.

28. The method according to any of PP-27, in which the material is fed into the gas stream, taking the substance.

29. The method according to p, in which the gas stream is served under such pressure that he passed around the posterior edge of the nasal septum and out the other nostril of the person.

30. The method according to p or 29, in which the flow of gas entrained substance, created by actuation of the inlet part.

31. The method according to item 30, in which the gas stream is separated from the stream exhaled by a person.

32. The method according to item 30 or 31, in which, in addition, regulate the volume flow rate of gas supplied to the inlet part.

33. The method according to p or 29, in which the flow of gas entrained substance, create through crilical and, driven by the flow of exhaled by a person.

34. The method according to p or 29, in which the flow of gas entrained substance, create by means of the stream exhaled by a person.

35. The method according to any of PP-34, which, in addition, create a hydraulic resistance to the flow of gas coming out the other nostril, to maintain the dynamic of the excess pressure in the nasal airway of the person.

36. The method according to p, in which the dynamic overpressure is of sufficient magnitude to force disclosure, at least one of the auditory tube or pazuhanich pipes.

37. The method according to p or 36, in which, in addition, regulate the hydraulic resistance while maintaining the dynamic excess pressure in the nasal airway of the person.

38. The method according to any of PP-37, in which the dynamic overpressure is at least 5 cm Vogt

39. The method according to p, in which the dynamic overpressure is at least 50 cm Vogt

40. The method according to § 39, in which the dynamic overpressure is at least 100 cm Vogt

41. The method according to p, in which the dynamic overpressure is at least 200 cm Vogt

42. The method according to any of PP-41, in which, in addition, serves, at least one of video or audio si is Nala upon reaching a predetermined pressure in the nasal airway.

43. The method according to any of PP-42, in which the supply of the substance is performed by the flow of exhaled by a person.

44. The method according to any of PP-43, in which, in addition, serves, at least one of video or sound when exhaling man.

45. The method according to item 44, in which the video signal is expressed in the appearance on the mind tools display.

46. The method according to any of p-45, which as substance use dry powder.

47. The method according to any of p-45, which as substance use liquid droplets.

48. The method according to p in which droplets contain one of the solution or suspension.

49. The method according to any of PP-48, in which the main fraction of particle size distribution is in the range of about 1-10 microns.

50. The method according to § 49, in which the granulometric composition essentially is in the range of about 1-10 microns.

51. The method according to any of PP-50, which as substance use drug.

52. The method according to § 51, in which the drug is intended for treatment of diseases of the nose.

53. The method according to any of PP-50, which as substance use cleanser to clean the nasal Airways.

54. The method according to any of PP-50, which as substance use washing means for washing the nasal Airways.

56. The method according to any of PP-54, used to treat inflammation of the nose, in particular rhinitis.

57. The method according to any of PP-54 used for the treatment of polyps in the nose.

58. The method according to any of PP-54 used for the treatment of hypertrophic adenoid.

59. The method according to any of paragraphs. 24-54 used for the treatment of secretory otitis media.

60. The method according to any of PP-54 used to treat low smell.

Priority items:

03.03.1999 according to claims 1, 2, 4-6, 8-16, 19-26, 28-31, 33, 34, 42-48, 51-56, 58, 59;

03.03.2000 on PP, 7, 17, 18, 27, 32, 35-41, 49, 50, 57, 60.