Inhalator dosing device. RU patent 2248224.
 Medicament dosage device / 2245169The medicine portioner has a casing with a cavity for holding of medicine agents with a mouthpiece fastened to it, button and a proportioning mechanism. The dosage mechanism is made in the form of a rod with a proportioning bush concentrically placed on it, made for mutual axial displacement, for adjustment of doses. The rod is made stepped for axial displacement relative to the casing and spring-loaded by a return spring. A spring-loaded piston is installed in the cavity for dosage of the medicine agents. Ports for air supply are made in the casing opposite the mouthpiece. All the ports or part of them are made tangentially with respect to the rod. A swirler and a safety net are installed inside the mouthpiece. |
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Medicament dosage device / 2245169 The medicine portioner has a casing with a cavity for holding of medicine agents with a mouthpiece fastened to it, button and a proportioning mechanism. The dosage mechanism is made in the form of a rod with a proportioning bush concentrically placed on it, made for mutual axial displacement, for adjustment of doses. The rod is made stepped for axial displacement relative to the casing and spring-loaded by a return spring. A spring-loaded piston is installed in the cavity for dosage of the medicine agents. Ports for air supply are made in the casing opposite the mouthpiece. All the ports or part of them are made tangentially with respect to the rod. A swirler and a safety net are installed inside the mouthpiece. |
 Inhalator dosing device / 2248224Method involves collecting fine powder on dosing unit surface as elongated doses. Single use dosing unit has several prefabricated dose strips to which access is provided. The dosing member having corresponding opening moves along elongated strip of the dosing unit when introducing drug increasing in this way time interval spent for releasing pharmaceutical composition from the dosing unit into inhalator air flow near the entry. Relative movement of the dosing member is achieved by rotating the dosing unit itself or by moving the dosing member along dosing unit surface. |
 Device for applying ozone therapy / 2249445Device has medical oxygen source, pressure control unit, ozone generator, loader with destructor, gas discharge switch placed between the ozone generator and pressure control unit and three-way valve with an additional destructor. The destructor is connected to valve outlet open in normal state which outlet closed in normal state is connected to load source. |
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Method for treating chronic bronchopulmonary process at inborn defects of pulmonary development in children / 2253484 The innovation includes the impact of haloinhalations from table haloinhaler "Haloneb" at the mode of 0.4-0.6 mg/min in pre-school-aged children and the mode of 0.8-1.2 mg/min in schoolchildren for 10 min. Then for 5 min it is necessary to perform deep slow inhalation through haloinhaler, pause 4-5 sec and expiration into flutter, about 10-12 procedures/course at the background of basic therapy. The method enables to decrease sputum stasis due to improved rheological properties of bronchial secreta and activated function of ciliated epithelium, decreased inflammation, edema and obstruction in bronchi, improved local immune and metabolic processes. |
 Method for treating prostatitis / 2254866One should introduce mineral water named "Yessentuki 17" once daily for animals with prostatitis pattern for 23-24 d along with the course of inhalations by applying essential oils with the help of a phytoaeroionizer daily for 5-6 min, about 12-14 procedures/course. One should apply essential oils of sage, lavender and mint at the ratio of 1:1:1. The method enables to normalize both lipid and carbohydrate metabolism and decrease blood content of prolactin and estradiol. |
 Feeding apparatus for nose / 2258538Feeding apparatus has part for closing of individual's stomatopharyinx palatal curtain and feeding part for supplying gas flow for entraining of substance into one of individual's nostrils under delivery pressure providing passage of gas flow around rear edge of nasal septum and exit from other nostril. Feeding part has tip including discharge pipe for feeding gas flow into one nostril, and sealing member for sealing one nostril relative discharge pipe so as to prevent gas flow from leakage through other nostril. |
 Powder inhaler / 2258539Powder inhaler has casing equipped with air inlet apertures and aerosol discharge aperture and adapted to be covered with protective casing. Said apertures are connected with air pipeline equipped with speeding-up channels connected with disperser. Powder inhaler is further equipped with container for storage of powder, and dosing device formed as movable plate with measuring aperture for feeding of powder dose into speeding-up channel. Movable plate of dosing device is equipped with additional measuring aperture identical to above mentioned measuring aperture and spaced from axis of rotation of dosing device by the same distance and offset relative first mentioned aperture by angle of 90° so that upon turning of dosing device each of said measuring apertures is alternatively arranged under aperture in base of container for powder or under one of speeding-up channels. Each of speeding-up channels is separated by partition wall protruding from one of speeding-up channel walls at its outlet end. Said wall tightly adheres to movable plate of dosing device and is extending above measuring aperture across two channels so that one of channels is connected with disperser and other channel is communicating with first channel through measuring aperture. |
 Method for suppressing atypical pneumonia coronavirus / 2266757Method involves administering ultrasonic ozonide-containing drug aerosol inhalation as ozonized oil and water mixture. Ultrasonic inhalation is additionally applied to bronchopulmonary system using highly refined aerosol containing ozonized oil having ozonide-based peroxide number P=800-900 and aerosol particle diameter equal to 0.3-0.5 mcm, giving at least two sessions per day at pathologic process active phase stage. Bronchopulmonary system tissue edema being relieved, ultrasonic inhalation procedure is first applied using highly refined aerosol containing ozonized oil having 20% ozonized oil emulsion of oil-in-water type having peroxide number P=200 and aerosol particle diameter equal to 0.3-0.5 mcm, giving at least two sessions per day at infection regeneration stage until clinically proved patient recovery data being obtained. Next, ultrasonic inhalation procedure is applied using medium refined aerosol containing ozonized oil having peroxide number P=800-900 and aerosol particle diameter equal to 5.0-10.0 mcm, each inhalation procedure being at least 10 min long. |
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Method for treating children for primary arterial hypertension / 2271797 Method involves sequentially administering ultrasonic inhalations with sodium hydrocarbonate alkaline mineralized and boric mineral water with increased fluorine concentration at aerosol flow speed being equal to 5 l/min during 3 min with following olive oil or other kernel oil inhalation. Then laser radiation therapy is applied to skin above left cubital vein with pulse frequency of 80 Hz and C YII-Th IY reflexogenic segmental zones are treated next to it during 5 min on the left dorsal side at pulse succession frequency being equal to 3000 Hz, pulse power of 2 W alternating it every other day with balneological hydrogen sulfide treatments given to boys at hydrogen sulfide concentration of 50-100 mg/l and to girls at hydrogen sulfide concentration of 25-50 mg/l. The total treatment course is 8 balneological treatments and 10 physiotherapy procedures long. |
 Air-ionization chamber / 2274475Air-ionization chamber comprises air ionizer that receives needle electrode and axially mounted hollow cylinder whose passage is used for flowing the agent to be inhaled, inlet branch pipe, and high-voltage unit whose negative pole is connected with the needle electrode. The positive pole of the high-voltage unit is connected with the ground bus, and the hollow cylinder is made of insulating material. The needle electrode is made of beams mounted perpendicular to the axis of the air ionizer whose ends are provided with needles. |
FIELD: medical engineering.
SUBSTANCE: method involves collecting fine powder on dosing unit surface as elongated doses. Single use dosing unit has several prefabricated dose strips to which access is provided. The dosing member having corresponding opening moves along elongated strip of the dosing unit when introducing drug increasing in this way time interval spent for releasing pharmaceutical composition from the dosing unit into inhalator air flow near the entry. Relative movement of the dosing member is achieved by rotating the dosing unit itself or by moving the dosing member along dosing unit surface.
EFFECT: uniform powder distribution when moving along elongated dose strip during 1-2 s long inhalation.
10 cl, 5 dwg
The scope of the invention
This invention relates to a dosing device for an inhaler and in particular to such a dosing device, which during inhalation, performed for the introduction of pharmaceutical substances, provides a slower introduction of this substance for its passage in the deep areas of the lungs of the patient.
Background of the invention
Among inhalers developed today, there are devices from very simple to quite complex. Almost all modern inhalers used any type of mechanical dosing for preparation of doses that must be administered by inhalation. Often the creation of a dose is pre-industrial way - in the form of blister packs containing from 10 to 50 doses. Such blister packs are placed in the inhaler as the source of each dose. Other inhalers have the shop, the powder of which is dosed by a specific device with the distribution in the air you breathe. In both cases, the powder usually is selenagomezfans and therefore it is necessary to dissipate.
Currently, such a dispersion of agglomerates carried out mainly by means of the method in which use the energy of the inhaled air. Normal breath lasts about two seconds, and the quiet breath - 3-4 seconds. In such devices, where deagglomerate use only the air you breathe is only a part of the energy of the air, because the dose of the powder is normally introduced only 0.1-0.4 sec. This leads to inefficient use of energy actually present in the air we breathe. Because this is only a small part of the energy, it will not be sufficient to ensure proper dispersion. As a consequence, the total inhaled dose is strongly dependent on the circumstances of a particular patient and will vary substantially from case to case. To improve this situation, some inhalers are equipped with a special device, which must face the moving powder, thereby converting the energy of motion into energy of deagglomerating powder. However, this collision with fixed or mechanically movable object leads to the fact that a fairly large number of powder or sticks firmly to the object or carried on with the next dose. In both cases it is a negative factor for ensuring high quality and accuracy of the inhaled dose, for example a precise amount of powder with a high percentage of very small particles.
In international publication WO 97/00704 described inhalator device, which is designed to introduce the substance is charged by static electricity, and the dosing is done by rotating the metering drum which attracts the charged particles of the specified substances. Then this substance ejected from the metering drum through the combined impact of the additional electric field and the resulting inhaling air flow. Before the phase of the desired dispensing intended for the introduction of the substance stored in the tank, the loading of which is produced, for example, by placing a cartridge containing a substance with repeated use of the device.
Still there is a need in the inhaler for the inhalation of appropriate therapeutic substance through which it inhaled the substance throughout the entire breath is distributed more evenly compared with what takes place when using the known inhalers.
The invention
Suggested dosing device nebulizer for administration of the pharmaceutical composition over a long period of time. Intended for the introduction of powder is laid on the outer surface of the metering element in the form of an elongated dose or band of fine powder. The metering element contains several prepared doses accessed. The metering component that has a corresponding hole during injection is moved along the elongated dose, located on the metering element to thereby increase the period of time during which the pharmaceutical composition when the breath is released from the metering element in the air flow nebulizer. The specified move or provide rotation of the metering element by either moving the metering component along the surface of the metering element. Thus, in accordance with the movement of the metering component or metering element provides uniform distribution of very fine powder in the air we breathe within, for example, one-second breaths.
The proposed device described in the independent claim 1 of the claims, and additional options for its implementation are presented in the dependent paragraphs 2-10 of the claims.
A brief description of the drawings
The invention and its other objectives and advantages, the best way can be understood from the following description given with reference to the accompanying drawings, in which:
figure 1 depicts a graph illustrating the difference between the introduction of a powdered therapeutic compositions using the proposed method and with the method of the corresponding prior art;
figure 2 depicts a first embodiment of the proposed metering drum containing straight lines of a fine powder;
figure 3 depicts a second embodiment of the proposed metering drum containing a circular strip of fine powder;
figure 4 depicts the third variant of the metering element in the form of a rotary disk having elongated strip doses of powder intended for injection; and
figure 5 depicts a fourth variant of the metering element in the form of a square plate having elongated rows of containers with a thin powder intended for injection.
Detailed description
This invention is directed to the provision of metering-in substances, the duration of which at the breath should be increased to a certain minimum period of time. Figure 1 presents a graph in which the dotted curve shows the normal duration of dosing provided by the inhaler in accordance with the previous prior art. All available for dispensing the powder is released into the air you breathe within 0.2 to 0.3 seconds. To obtain the best distribution of pharmaceutical substances in the air we breathe, to ensure the actual achievement of that substance deep zones in the lungs of the patient a more acceptable time release doses of a substance is between about 1.5-2 seconds. The solid curve illustrates the distribution of the substances in the air we breathe, in accordance with the proposed in the present invention the solution of the problem.
Figure 2 depicts a first embodiment of the invention, representing a one-time dosing element in the form of a drum 10, which applied the ideas of the present invention, associated with extension of time within which the introduction of inhaled substances. On the cylindrical surface of the metering drum 10 are elongated strips 15, 16 prepared a very fine powder therapeutic composition that needs to be entered. The drum 10 rotates around the Central axis 12 in the direction indicated by the arrow 14, to select one of the ready-to 16 doses. The metering component 7 in the form of a tube or nozzle is moved along the selected dose of 15 in the direction indicated by the arrow 30. The metering component 7 is attached to the mouthpiece (not shown) of the inhaler and breathe air carries therapeutic composition in an inhaler manner well known to the person skilled in the art.
In yet another embodiment, the casing shown in figure 2 of the metering drum 10 may be located on the sites of a flat surface parallel to the Central axis of the drum and intended for elongated strips of prepared doses of powder. This provides the closest accommodation metering component 7 from a specified band across its width so that when you move the specified metering component 7 along this elongated strip therapeutic composition during injection of the powder is most effective to capture.
Figure 3 shows a second embodiment of a disposable dispensing drum 10, intended for realization of the proposed method. In this embodiment, the strip containing the dose or even part of the dose is made in the form of concentric grooves 17, encircling the metering drum 10. The metering component 7 in the form of a tube or nozzle is moved in the direction indicated by the arrow 31, to select the grooves 18 with the dose. Then the metering drum during the injection of the indicated dose rotate around the axis 12 in the direction of the arrow 14. As in the first embodiment, shown in figure 2, the metering component 7 is attached to the mouthpiece (not shown) pump means, well known to the person skilled in the art.
Another embodiment of the present invention are presented in figure 4. Disposable element is designed in the form of a circular disk 10 having radial grooves 19, designed for operation at doses of injected therapeutic composition. By rotation of the disk 10 around the Central axis 12 choose the radial groove 20 with the metering component 7, and the specified component with the breath move along this radial grooves in the direction of arrow 30 to thereby lengthening the time of implementation to the desired period of time of about 1-2 seconds instead of a few tenths of a second, as is the case when using known devices.
Finally, figure 5 shows another embodiment of a disposable metering element in the form of a square plate 11 having elongated rows of tanks entered therapeutic composition. The number of containers 22 selects, for example, by moving the metering component 7 in the direction indicated by the arrow 31. During inhalation, the metering component is moved in the direction of the arrow 30 similar to that produced in the first embodiment. Inlet metering component 7 passes over the selected containers 22, shown as applied to this variant execution figure 5. Specialist in the art it is clear that therapeutic composition can be depicted in figure 5 tanks 22 and elongated grooves passing, for example, in the direction of the arrow 30.
Disposable element, containing a pre-fabricated dose of very small particles (preferably of the order of several microns), can be protected in the usual manner, for example by forming protective films, which in the preferred case, remove one for each dose, so as to keep the rest of the contents of a specified one-time item in washdown conditions to prevent undesirable agglomeration of the pharmaceutical substance.
In different versions of the nebulizer adapted to this disposable metering element for controlling and synchronizing the movement of the metering component 7 and consequently ensure the proper release of the powder during its introduction air speed can be measured by known sensor air flow. For example, control device that uses a flow sensor air, available on the inhaler described in the aforementioned international publication WO 97/00704.
Specialists in the art will understand that various modifications and changes of the invention, not beyond the scope of legal protection established in the attached claims.
1. The metering device nebulizer for administration of the pharmaceutical composition in the form of fine powder, intended for inhalation, characterized in that intended for the introduction of the pharmaceutical composition has the form of an elongated doses (16, 17, 19, 22) fine powder located on the surface of the metering element (10), while the metering element contains several pre-prepared doses, accessed, and a metering component (7) with the corresponding hole, moving in elongated along a specified dose (16, 17, 19, 22) to increase the period of time during which during inhalation pharmaceutical composition is discharged from the metering element in the air flow inhaled devices to provide thereby a uniform distribution of fine powder in the air we breathe.
2. The device according to claim 1, characterized in that the metering element (10) is a circular drum having elongated doses fine powder, which is a pharmaceutical substance, intended for injection.
3. The device according to claim 1, characterized in that the metering element (10) is a disk having elongated in the radial direction doses fine powder, which is a pharmaceutical substance, intended for injection.
4. The device according to claim 1, characterized in that the metering element is a plate (11)having rows of containers (22), which contain intended for the introduction of the substance and along which during the introduction moves the metering component (7).
5. The device according to claim 1, characterized in that the outer surface of the metering element (10) is an elongated, essentially flat surface (15, 16), each of which is designed to accommodate the dose of a certain width, representing a pharmaceutical composition in the form of fine powder.
6. The device according to claim 1, characterized in that the outer surface of the metering element (10) is placed around the circumference of the channels (17, 18)containing fine powder pharmaceutical composition.
7. The device according to claim 1, characterized in that the aperture metering component (7), moving along the extended dose of fine powder on the dosing element is moved by a drive device controlled by the speed and quantity of inhaled inhalation of air.
8. The device according to claim 1, characterized in that the aperture metering component (7) forms a small hole in the plate that covers located on the dosing element the directional dose of fine powder, the said holes in the plate inhalation additionally distribute pharmaceutical composition in the air we breathe.
9. The device according to claim 7, characterized in that the drive device is controlled electrically control device constituting an electronic circuit for measuring parameters of the air flow.
10. Device according to any one of claims 1 to 9, characterized in that the metering element (10, 11) is a replaceable disposable packaging pre-packaged with elongated doses containing pharmaceutical composition intended for the introduction.