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IPC classes for russian patent Method for evaluating inflammatory process activity in infantine osteomyelitis cases (RU 2252419):
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Method for evaluating inflammatory process activity in infantine osteomyelitis cases / 2252419
Method involves separating blood serum proteins into fractions, determining albumins and alpha-2-globulins content and controlling their content changes during the disease development process. Gamma-globulin content is determined in per cent ratio with respect to total protein quantity. Then, changes in the fractions content are controlled from the first to the third week. Albumin content being in norm and alpha-2-globulins content becoming greater to the end of the first week by 30-50% when compared to normal value and dropping to norm at the second week end and gamma-globulin content increasing from norm by 10-30% to the second or the third week, high inflammatory process activity is to be diagnosed. Albumin content dropping by 10-30% from normal value at the second week, alpha-2-globulins content growing by 10-20% of norm and gamma-globulin content dropping by 30-50% at the second or the third week when compared to norm, low inflammatory process activity is to be diagnosed.
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FIELD: medicine.
SUBSTANCE: method involves separating blood serum proteins into fractions, determining albumins and alpha-2-globulins content and controlling their content changes during the disease development process. Gamma-globulin content is determined in per cent ratio with respect to total protein quantity. Then, changes in the fractions content are controlled from the first to the third week. Albumin content being in norm and alpha-2-globulins content becoming greater to the end of the first week by 30-50% when compared to normal value and dropping to norm at the second week end and gamma-globulin content increasing from norm by 10-30% to the second or the third week, high inflammatory process activity is to be diagnosed. Albumin content dropping by 10-30% from normal value at the second week, alpha-2-globulins content growing by 10-20% of norm and gamma-globulin content dropping by 30-50% at the second or the third week when compared to norm, low inflammatory process activity is to be diagnosed.
EFFECT: high accuracy and reliability of diagnosis.
The invention relates to medicine, namely to surgery, traumatology, orthopedics, and can be used in the assessment of inflammatory activity osteomyelitis in children.
There is a method of assessing the activity of the inflammatory process on the value of adequate indicators of the inflammatory response (PAVRA), which is based on laboratory studies hemogram, levels of IgG, IgM, IgA, level hemolytic complement, F and FI. A significant increase in the PAVRA will correspond to an active inflammatory process, the lowest PAVRA indicates low activity of the inflammatory process (Mashkov AU “explanation of complex treatment of complicated forms of purulent-septic diseases in children”, Thesis for the degree of doctor of medical Sciences, M., 1998, p.70-73).
It should be noted that the PAVRA is a probabilistic value that should be considered in combination with other factors: the level of toxicity, MSM (molecules of average weight), GENDER (peroxidation over), state kallickrein-kinin system and other
The disadvantage of this method is that for obtaining the parameters of the PAVRA and investigation of other factors necessary to conduct a sufficiently large number of clinical studies, some of them require large Finance is x cost and time that, accordingly, affects the reliability and timeliness of evaluation activity process.
In addition, the complex studies of blood, used in the known method, does not take into account the fact of the pathogenesis of the inflammatory process as a violation of the protein in the blood, which greatly reduces its information content.
There is a method of assessing the activity of inflammatory process in osteomyelitis involving separation of serum proteins into fractions, determination of albumin and alpha-2-globulin and control over their content altered in the disease process (GN. Akihito and other “Osteomyelitis”, M.: Medicine, 1986, p.42).
The disadvantage of this method is the lack of accounting for and control for changing the content of gamma-globulin in the disease process, which are the indicator of humoral immunity, which reduces the information content and, consequently, the reliability of the obtained results.
In accordance with this task, aimed at improving the reliability by analysis of integral blood counts, providing accurate and reliable assessment of the activity of the process that will allow timely correction (to activate hyperviscous and to inhibit giperergicakie reaction).
This task is solved in that in the method of assessment of the activity of the inflammatory process in osteomyelitis in children involving separation of serum proteins into fractions, determination of albumin and alpha-2-globulin and control over their content altered in the disease process, further define the content of gamma-globulin as a percentage of the total number of protein, followed by a 1 to 3 week control the change of the content of these fractions, while under normal albumin levels, increased levels of alpha-2-globulin by the end of 1 week from the norm by 30-50% and decrease to normal to the 2nd week, the increase in the content of gamma globulin from the norm by 10-30% to 2-3 week estimate high activity the inflammatory process and in the reduction of albumin from the norm by 10-30% to 2 week, increased alpha-2-globulin from the norm by 10-20%, the reduction of gamma globulin from the norm by 30-50% to 2-3 week estimate low activity of the inflammatory process.
The implementation of the method is illustrated with specific examples.
Ill Worlds I., age 9, and/b 13392, Ds - osteomyelitis of the right femur.
In the study of blood serum selected fractions: albumin, alpha-2 and gamma-globulins. This fraction was estimated % of the total protein quantity. In the acute period of the disease (onset 1 week of illness) albumin was 51%, which corresponds to the normal value (50-60%), alpha-2-globulin amounted to 12.7% of the total protein quantity (rate of 7-11%), gamma-globulin 10,9% of the total protein quantity (norm 13-19%). To the 2-3 week of the disease albumin 43% (normal), alpha-2-globulin was 13.6%, and gamma-globulin 10,5 indicating low activity of the inflammatory process. In accordance with this were assigned immunokorrektiruyuschie drugs, quantum therapy.
Sick Chatwal A., age 5, and/b 6112, Ds - osteomyelitis of the right thigh. In the study of blood serum selected fractions: albumin, alpha-2 and gamma-globulins. In the acute period of the disease (onset 1 week of illness) albumin was 56,9% (normal 50-60), alpha-2-globulin was 15.2% of the total protein quantity (rate of 7-11%), gamma-globulin 16,2% of the total protein quantity (norm 13-19%). To the 2nd week of illness albumin 55,5% (normal 50-60), alpha-2-globulin was 10.5%, and gamma-globulin 23%, which indicates a high activity of the inflammatory process. In accordance with this assigned asteroideae anti-inflammatory drugs, hormone therapy, extracorporeal detoxification.
Using this method will reliably in a short period of time to assess the activity of the inflammatory process that will allow time to conduct effective interventions, varying depending on the activity of the process.
A method of evaluating the activity of vocal the construction process when osteomyelitis in children involving separation of serum proteins into fractions, determination of albumin alpha-2-globulin and control over their content altered in the disease process, characterized in that it further determine the content of gamma-globulin as a percentage of the total number of protein, followed by a 1 to 3 week control the change of the content of these fractions, while under normal albumin levels, increased levels of alpha-2-globulin by the end of 1 week from the norm by 30-50% and decrease to normal to the 2nd week, the increase in the content of gamma - globulin from the norm by 10-30% to 2-3 week appreciate the high activity of the inflammatory process, and at lower albumin from the norm by 10-30% to 2 week, increased alpha-2-globulin from the norm by 10-20%, the reduction of gamma-globulin from the norm by 30-50% to 2-3 week estimate low activity of the inflammatory process.
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