Tablets for oral hygiene and method for their obtaining

FIELD: medicine, hygiene.

SUBSTANCE: the present tablets are designed in solid form and contain the substance of purifying action in the form of finely dispersed insoluble abrasive components, SAS, aromatizing agents, dyestuffs, thickening agents, moreover, the content of water in components should be decreased by 35-37%. The suggested tablets should be prepared due to mixing the components with water to form solid forms out of obtained homogeneous plastic material at the room temperature to be then dried up and packed. Tablets for disposable intake provide great consumer's latitude being very convenient at usage.

EFFECT: higher efficiency of application.

16 cl

The invention relates to dentistry and cosmetology, namely the creation of tools for oral hygiene.

Currently, there are many variants and forms of oral compositions for oral hygiene in the form of toothpastes, gel tools, tooth powders, liquids to rinse and refresh the mouth, chewing gums, tablets, pellets, sprays and other Oral compositions contain in its formulation components intended for cleansing the teeth, keeping the teeth and gums in good condition and remove odors.

Patented new composition with modified physical properties of toothpastes with low fluidity (patent RU 2127581), in which the vein of toothpaste can easily tear and does not spread, which improves the dispensing of toothpaste. The desire to improve the physical properties of toothpaste or gel leads to the creation of viscoelastic compositions (patent RU 2089176). There are toothpastes in which the active substance is dense granules, which razduplyayutsya toothbrush (patent RU 2139034). Known solid oral composition in the form of chewing gum, cakes, candy (patent RU 2163480, 2148395, 2097020). The use of oral compositions in the form of razdevauschihsya or dissolving tablets has long been known and widely used. Razdevauschiesya tablets with oral compositions usually COI is lesuuda for the rapid absorption of the active therapeutic component through the mucous membrane of the oral cavity (patents US 4820523, 606078) etc. Sometimes technology is used to enable the active substance in microcapsules, which shrunk in the filler that hides the taste of the active substance when chewed or the medication is not intended for dissolution in the mouth (US patents 4786502, 4609542, 4882152, 4851226, 5459436).

Oral compositions in absorbable or razdevauschihsya tablets are widely used in oral hygiene in children. In the United States in children 6 years of age are used tablets containing fluorine and vitamins, for example, Poly-Vi-Flor. (American Academy of Pediatrics, Committee on Nutrition/ Fluoride Supplementation for Children: Interim Policy Recommendations/ Pediatrics/ 1995; 95:777).

Also available tablets for oral cavity containing calcium and fluoride (US patents 5476647, 5891448). Created types of tablets which rapidly disintegrate in the mouth with a rapid release of the active substance (patent US 5464632). They can be used as a carrier of various therapeutic substances. Tablets are sensitive to damage and require specially designed packaging. This limits their applicability. The production of these tablets is expensive. They are mostly used in Pediatrics. There are recipes tablets for oral hygiene containing special ingredients for cleansing the teeth, for example, proposed in the molten sorbitol to engineer triclosan. Then, the mixture is left to harden in anatoy temperature. From this mixture it is possible to form a pellet, which is then resolved in the mouth. Instead of sorbitol can be used other sugars (patent RU 2097020). There have been attempts to create tablets for oral hygiene, which are part of mannitol.

The closest technical solutions are tablets for the treatment of oral cavity, described in patents US 3932606 and 4132772. In these patents are invited to a special composition for oral hygiene in the form of tablets with mannitol. A tablet weighing about 0.5 grams need to crumble teeth, and after soaking parts of the tablet saliva when chewed mannitol begins to dissolve in the mouth. Then the solid particles in the composition of saliva and mannitol clean the teeth. The disadvantage of these developments is that the compositions have a high sugar content (47,3% mannitol) and about 36% of water-insoluble detergent. The remainder are inactive additives, flavorings and antimicrobial agents.

The present invention is to eliminate above-mentioned disadvantages when creating tools for oral hygiene in the form of tablets, dosed for single use and having the properties of toothpastes.

The proposed group of inventions combined to form a single inventive concept.

Means for oral hygiene in solid Faure is e contains a substance cleansing action in the form of finely dispersed insoluble abrasive components, surfactants, flavorings, if necessary, sugar, medicines, dyes, thickeners, and the water content of the components included in the composition of funds, reduced by 35-75%.

The tool further comprises glycerol to 20% of the original components.

As a matter cleansing action, it comprises substances selected from the group of: calcium carbonate, calcium phosphate, magnesium carbonate, silicon dioxide, titanium dioxide.

As surface-active substances it includes a substance selected from the group: sodium sulfate laurinovoj acid, N-methyltaurine, N-lauryl acrosin sodium.

As flavoring it comprises substances selected from the group of: menthol, aquamentus, natural flavors.

As the sugars it contains a substance selected from the group of sorbitol, aspartame, mannitol.

As a drug it includes a substance selected from the group of silver, soluble fluorides of alkali metals sodium fluoride, monovalent copper fluoride.

As thickeners it includes a substance selected from the group of cellulose, food adhesives such as gelatin.

The tool is made in the form of pellets, tablets.

A method of cooking tools for oral hygiene in solid form, which consists in the fact that the composite whom onesty, the water content of which is reduced by 35-75%, is mixed with water, obtained from a homogeneous plastic material at room temperature to form a solid form, which are dried and Packed.

Solid forms made in the form of pellets, tablets.

Solid forms dried at room temperature or under mild heating or vacuum.

Solid forms additional paint or varnish and sprinkled with colored sugar.

Means in the form of tablets, pellets are Packed in blisters or in the form of disposable packaging in the form of candy.

The hardness of tablets, pellets regulate adding to the initial mixture of glycerol to 20%.

On the surface of tablets, pellets put drawing or stamping.

The proposed remedy for oral hygiene in the initial stages of getting resembles the production of conventional toothpastes. The proportions of all components generally correspond to the proportions of toothpastes with the exception of low water content. By reducing the water content in the mass used for the production of toothpaste, it is not a liquid paste, and a dense mass from which it is possible to form a tablet, pellet, etc. the water Content is selected depending on the composition of the initial toothpaste. The criterion for the proper selection of the ratio of water and solid products for the concrete mixture is one which by the possibility of obtaining a dense objects, which retain the shape imparted to them. The finished product prior to contact with water is not pasta, but has all the properties of toothpastes that occur when chewed his mouth and contact with water.

For the manufacture of the tool used songs existing toothpastes. They usually consist of the following components:

water-insoluble powdery substance cleansing actions, such as calcium carbonate, calcium phosphate, magnesium carbonate, silicon dioxide, titanium dioxide or other fine insoluble abrazivnye components;

surfactants, such as sodium sulfate laurinovoj acid, N-methyltaurine, N-lauryl acrosin sodium or other means;

aromatic substances, such as phenolic flavors containing menthol, aquamentus or natural flavors;

sugar, such as sorbitol, aspartame, mannitol and the like;

various treatment additives, such as silver or soluble fluorides of alkali metals: sodium fluoride, monovalent copper fluoride and antibacterial components, for example: N.sup.1-(4-chlorobenzyl)-N.sup.5-(2,4-dichlorobenzyl) biguanide; p-chlorophenyl biguanide; 4-chlorobenzylhydril biguanide or other non-toxic substances.

In the mix also add glycerin or include solutions of sorbitol, propylene glycol or polyethylene glycol. Add zagustitel is, for example cellulose, food and adhesives such as gelatin from 0.2 to 10%. Perhaps the use of other components, which are widely used in the manufacture of toothpastes. Water is obligatory in all toothpastes. Its content varies depending on the specific recipe toothpaste from 35 to 75%. Water can be household, the hardness of water is not limited. Permissible content of calcium carbonate up to 500 ppm.

Unlike ready toothpaste ready mix for the production of tablets like thick thick dough or clay sculpture. This mass is not Packed in the tubes, as is done in the manufacture of toothpastes, and at room temperature to form tablets or objects other form, which, after final drying at room temperature or under accelerated drying by heating is at a temperature of 50-80 degrees or in a vacuum chamber packaged or optionally undergo further treatment: painted, varnish, sprinkle colored powder etc. On them can be applied to the drawing or stamping. The hardness of the tablets can be varied depending on the residual water content. Perhaps the use of glycerol to 20% in the initial mixture. The finished tablets before contact with water are not pasta. They retain a stable form, they are solid, can be razlichno the magnitude and already dosed for a single use. In contrast to the known tablets announced the tablet has an elastic texture and is easily dissolved in the mouth. After being hit in the mouth and grinding with water, the tablet turns into a liquid toothpaste and performs all the functions of toothpaste. Unlike known it does not contain additives that reduce the effectiveness of the active components do not mix with melted sugars (beckons, mannitol, sucrose and the like), not vplavlyatsya and not pressed into them. The sugar content is lower than in known forms.

To test the effectiveness of the proposed drug were made tablets and toothpaste having the same composition except for water content. The water content in the tablets was 2-25% lower. The test was carried out with the participation of the firm's Global Trials (Clinical Trial Management, 79312 Emmendingen, PB 1263, Germany), which was assigned technical tasks.

Test toothpaste to vacuum drying contained the following components at 100%:

Insoluble sodium metaphosphate 40,0

Sodium lauryl sulfate 3,0

Dicalcium phosphate dehydrate 4,0

Gum tragacant 1,5

Stannous fluoride 0.4 to

Natural aromatic oil 1,0

Water 30,0

Glycerine (99.3%) 17,9

Antimicrobial agent 0,1

Saccharin Na 0,6

Mass for the preparation of tablets was obtained in the premises of the test toothpaste in a vacuum chamber at a temperature of 60 degrees Celsius to weight loss by 20%. The resulting mass was prepared tablets, cat is that for full hardening were again placed in a vacuum chamber. The resulting tablets were compared with the standard toothpaste.

Participated in the testing of 24 adult subjects. All subjects had healthy teeth. Age ranged from 17 to 23 years. The test lasted for 5 days. 12 subjects used the reference toothpaste and 12 tablets of toothpaste. Dental hygiene was carried out 2 times a day. Quality teeth cleaning was carried out using the method of diagnostic staining of teeth reagent company Diaplague Co. Of Astra Sweden. The test results showed no differences between consumer characteristics test toothpaste and tablets. All subjects perceived the use of tablets as “useful” or “interesting”. Negative assessments were observed. Loss of taste or aroma was not observed when using tablets.

Tablets disposable provide more freedom of choice for consumers compared with hygiene products in tubes and bottles. For example, during working time or during a short trip is inconvenient to carry the standard 75-100 gram tubes or boxes with tooth powder. Enough to take a few pills of a new product. Bright colored tablets or figures can be interesting for children. Of particular interest this tool is for hotels. A survey conducted by Global Trils in Germany, showed that hotels guests use about 40-60% of the content on offer at the hotel tubes of toothpaste. Daily a large number of plastic tubes with the remnants of toothpaste that leaves along with debris.

You can produce these products in blisters or in the paper, in the form of candies, chocolates.

1. Means for oral hygiene in solid form, characterized in that it contains a substance cleansing action in the form of finely dispersed insoluble abrasive components, surfactants, flavorings, if necessary, sugar, medicines, dyes, thickeners, and the water content of the components included in the composition of funds, reduced by 35-75%.

2. The tool according to claim 1 further comprises glycerol to 20% of the original components.

3. The tool according to claim 1, as a substance cleansing action, it comprises substances selected from the group of calcium carbonate, calcium phosphate, magnesium carbonate, silicon dioxide, titanium dioxide.

4. The tool according to claim 1, as surface-active substances it includes a substance selected from the group of sodium sulphate laurinovoj acid, N-methyltaurine, N-lauroyl acrosin sodium.

5. The tool according to claim 1, as a flavoring, it comprises substances selected from the group menthol, aquamentus, natural ar is mitigatory.

6. The tool according to claim 1, as the sugars it contains a substance selected from the group of sorbitol, aspartame, mannitol.

7. The tool according to claim 1, in the quality of medicines it comprises substances selected from the group of silver, soluble fluorides of alkali metals sodium fluoride, monovalent copper fluoride.

8. The tool according to claim 1, as thickeners it comprises substances selected from the group of cellulose, food adhesives, for example, gelatin.

9. The tool according to claim 1 made in the form of pellets, tablets.

10. The method of preparation tools for oral hygiene in solid form, characterized in that the composite components, the water content of which is reduced by 35-75%, is mixed with water, obtained from a homogeneous plastic material at room temperature to form a solid form, which are dried and Packed.

11. The method according to claim 10, solid forms made in the form of pellets, tablets.

12. The method according to claim 10, the solid form is dried at room temperature or under mild heating or vacuum.

13. The method according to claim 10, solid form additional paint or varnish and sprinkled with colored sugar.

14. The method according to claim 10, the means in the form of tablets, pellets are Packed in blisters or in the form of disposable packaging in the form of candy.

15. The method according to claim 10, the hardness of tablets, pellets regulate adding to recognize the strong mixture of glycerol to 20%.

16. The method according to paragraph 10, on the surface of tablets, pellets put drawing or stamping.