Preparation "propovit with vitamin c" eliciting anti- inflammatory and antibacterial propertes

FIELD: medicine, parapharmaceutical industry.

SUBSTANCE: invention relates to industry manufacturing preparations for curative and prophylactic aims and can be used as a curative and prophylactic, bactericidal, antiviral, anti-inflammatory, analgetic agent promoting to regulation of respiratory organs. The preparation eliciting anti-inflammatory and antibacterial properties comprises dry concentrate of propolis alcoholic tincture, ascorbic acid, fruit essence dry concentrate, citric acid, calcium stearate and sugar taken in the definite ratio of components. The preparation expands assortment of medicinal agents used for treatment of acute and chronic diseases of respiratory organs and represents alternative variant for cases with individual intolerance of some components.

EFFECT: valuable medicinal properties of preparation.

1 tbl

 

The invention relates to medicine, in particular to the pharmaceutical industry for the production of drugs therapeutic and prophylactic purposes, and can be used as an auxiliary antibacterial, antiviral, anti-inflammatory, analgesic, contributing to the regulation of the respiratory system.

Known drug "Preterm" (Kaloshina N.A. and other life-giving balms, elixirs and extracts, Minsk, Harvest, 1997, n.218-219), representing 10% alcohol tincture of propolis has antimicrobial and anti-inflammatory action.

Known biologically active additive "Popovic" (provisional patents of RK No. 9328, class a 61 K 35/02, 35/64, 2001), available in tablet form and contains propolis in the form of a dry concentrate 10% alcohol tincture, citric acid, tincture of sweet clover and auxiliary substances: sugar, starch, calcium stearate used as antibacterial, antiviral, anti-inflammatory, analgesic, contributing to the regulation of respiratory means.

The disadvantage of this drug is indiv (dual intolerance patients of its individual components, as well as the lack of therapeutic efficacy.

The objective of the invention is to develop a new affordable drug is biologically asset is Oh supplements manufactured in pill form, convenient for using, contributing to the regulation of the function of the respiratory system and has more pronounced tonic effect.

The invention is directed to the expansion of the range of assistive devices for the treatment of acute and chronic respiratory diseases, alternative for cases of individual intolerance of the individual ingredients.

This object is achieved in that the proposed product contains dry concentrate alcohol tincture of propolis, citric acid, calcium stearate, sugar, and optionally ascorbic acid and dry concentrate fruit essences in the following ratio of ingredients in the tablet weight of 0.55 g, g:

dry concentrate alcohol tincture of propolis 0,0050-0,0070

ascorbic acid 0,0030-0,0060

citric acid 0,0030-0,0060

dry concentrate essences fruit 0,000001-0,000005

calcium stearate 0,0020-0,0060

sugar the rest

The drug that has anti-inflammatory and antimicrobial properties, called “Popovic with vitamin C and is a General tonic, antimicrobial, anti-inflammatory agent for the prevention and treatment of diseases of the respiratory organs, digestive organs, for increasing soprotivlyaemost body with infectious diseases, including tuberculosis, influenza.

Asorrow the OIC acid is in the drug potentiates the pharmacological action of propolis. Ascorbic acid is involved in regulation of oxidation-reduction processes, carbohydrate metabolism, clotting of the blood, regeneration of the tissues, formation of steroid hormones.

Dry concentrate essences fruit is not only flavor, but also provides additional introduction in the preparation of ascorbic acid (vitamin C).

The drug Popovic with vitamin C is obtained as follows.

The sugar in the number 49,23 kg weighed, visually check for the presence of mechanical impurities and then when no impurities are ground in a mill.

The output of crushed sugar - 48,985 kg;

Sugar sifted on the shaker through a sieve with the hole diameter of 1 mm; calcium stearate is sifted through a sieve with the hole diameter of 0.5 mm

Citric acid in the amount of 0,421 kg weighed. In the capacity load weighted tincture of propolis in the number 8,415 kg. Then portions upload citric acid when the agitator. Mix thoroughly to dissolve citric acid for 30 minutes at room temperature and filtered into the mixer through two layers of gauze.

Yield - 8,836 kg

In the mixer load 48,985 kg crushed and sifted sugar, moistened with a solution of citric acid tincture of propolis in the number 8,836 kg include peremeci the surrounding device and thoroughly stirred for 15 minutes.

Yield - 57,821 kg

Hydrated tablets weight in the number 57,821 kg laid out in trays with a layer thickness of 1,5-2 see Trays install in a drying Cabinet. Set the drying temperature 40-45°With the increase of which the flow of hot air is automatically disabled. The drying process should be performed within 8 hours to a constant weight at periodic stirring. The control end of the drying conduct in the laboratory by weighing samples of the product from the trays to a constant weight. The humidity of the product - not more than 2%. Dry tablet weight is directed to a dry granulation.

The output of the dry tablet weight - 49,824 kg

The dried mixture in an amount of 49,574 kg load portions in the device for producing granules from dry tablespace. Include a screw device, in which the mixture is forced through the mesh holes with a diameter of 1.5 mm, the Dry granulate is collected in the receiver. From the receiver the dry granules are loaded into the mixer. Add worn : 0.505 kg sieved calcium stearate, 0,421 kg of ascorbic acid, stirred for 15 minutes. The dry granulate is directed to tableting.

The yield of dry granulate - 50,5 kg

From the mixer the dry granulate in the number of 50.5 kg sent to tableting in the hopper tablet press machine. Include the engine, pre-installed on the company of the engine in accordance with a bulk weight, a compaction zone and the height of the tablet. The diameter of the tablet - 12±0.2 mm, the height of the tablets of 3.8±0.2 mm, average weight of tablet - 0.55 g ± 0,03.

During tabletting watching the machine work and quality tablets. Every 30 minutes check raspadaemost, the strength and the average weight of the tablets. Tablets are collected in the receiver and sent to the dust.

Yield - 50,25 kg

The finished tablets are sieved by the vibrating screen through a hole diameter of 8 mm, weighed 8 kg and load in a clean dry plastic bucket. Samples of finished tablets passed into the analytical laboratory for analysis. In accordance tablets norms technical documentation, prepared tablets passed the stage of packing.

The output of finished tablets - 50 kg

The sequence of operations is the same regardless of the number of prepared composition.

The drug Popovic with vitamin C contains known allowed for use in medical practice, the ingredients in this combination (see table 1, examples 1-4) provide for the reduction or disappearance of symptoms.

As auxiliary components, ensuring reliability maintain the shape of the pressed pellets in a dry form and a short time raspadaemosti them in a humid environment, used sugar, and to improve the flowability of the granules is tearin calcium.

Clinical trials were conducted on volunteers. During the observation of patients with typical symptoms (weakness, fatigue, cough, sore throat, lack of appetite) during the epidemic period OCR noted that the use of the drug "Popovic with vitamin C helps prevent and reduce the effects of acute respiratory infections, prevents the development of secondary infection. In particular, patients not receiving the drug, fell ill ARD 2.8 times more often. In this group during the observation period in two months ill 53.3% of patients, whereas in the group of patients taking the drug, diseases acute respiratory infections, bronchitis, pharyngitis was detected only in 13.3% of cases.

When prescribing the drug Popovic with vitamin C to patients infiltrative tuberculosis receiving standard treatment with specific anti-TB drugs, it was noted that the use of these drugs together can avoid the complications of tuberculous process. This makes it possible to achieve a more rapid disappearance of symptoms of intoxication in TB patients, which is important in the process of their treatment, as it allows to save time of hospital treatment.

Monitoring of patients suffering from cardiovascular diseases (ischemic heart disease, postinternationalism, hypertension I-II stage) and iron deficiency anemia, showed that the drug "Popovic with vitamin C is well tolerated and improves their overall status.

Starting with the first day of admission tested the drug in 15% of patients, and at the end of clinical trials (within 15 days) 50% of those surveyed noted stimulating, tonic effect, which is manifested by a decrease weakness, fatigue, change in the positive direction of the blood, from the second day in 20% of patients had marked diuretic effect.

Thus, the drug Popovic with vitamin C" may be recommended as a General tonic, antimicrobial, anti-inflammatory agent for the prevention and treatment of diseases of the respiratory system, the digestive system, the weakening of the body, to increase resistance to infectious diseases, including tuberculosis, influenza.





Table 1
 Content, wt. the share of g/PL. 0.55 g, example
Example1234
ComponentDry g/tab.Dry g/tab.Dry g/tab.Dry g/tab.
Dry the th concentrate alcohol tincture of propolis 0,00500,00570,00630,0070
Ascorbic acid0,00300,00400,00500,0060
Citric acid0,00300,00400,00500,0060
Dry concentrate essences fruit0,0000010,00000170,00000340,000005
Calcium stearate0,00200,00330,00460,0060
SugarStalin.Stalin.Stalin.Stalin.

*The number of initial raw material component used to prepare a tablet.

The drug has anti-inflammatory and antimicrobial properties, containing dry concentrate alcohol tincture of propolis, citric acid, calcium stearate and sugar, characterized in that it further comprises ascorbic acid and dry concentrate fruit essences in the following ratio of ingredients in the tablet weight of 0.55 g, g:

Dry concentrate alcohol

propolis tincture 0,0050-0,0070

Askorbinova acid 0,0030-0,0060

Citric acid 0,0030-0,0060

Dry concentrate essences

fruit 0,000001-0,000005

Calcium stearate 0,0020-0,0060

Sugar the Rest



 

Same patents:

FIELD: medicine, pulmonology.

SUBSTANCE: one should apply lycopid to study initial level of mature T-cells (CD3+) in % and solve following discriminant equation: D = 0.840 · (CD3+), and at D value being above 29.24 one should predict positive curative effect as a result of lycopid application, and at D value being below 29.24 on should predict no positive curative effect.

EFFECT: higher efficiency of lycopid-including therapy.

2 ex

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to new derivatives of indolylpiperidine of the formula (I): wherein A1 means (C1-C7)-alkylene, (C1-C7)-alkyleneoxy-, (C1-C7)-alkylenethio-, (C1-C7)-alkanoyl, hydroxy-(C1-C7)-alkylene; A2 means a single bond, (C1-C7)-alkylene, (C2-C5)-alkenylene; W means a single bond, phenylene, furanylene that is unsubstituted or substituted with one or more halogen atoms, (C1-C7)-alkoxy- and/or alkyl groups; R1 means hydrogen atom (H), (C1-C7)-alkyl, (C2-C7)-alkenyl, (C2-C7)-alkynyl, (C2-C5)-alkoxyalkyl, (C3-C7)-alkenyloxyalkyl, (C3-C7)-alkynyloxyalkyl, (C3-C7)-alkoxyalkoxyalkyl, phenyl-(C1-C7)-alkyl wherein phenyl is unsubstituted or substituted with one or more halogen atoms, (C1-C7)-alkyl, (C1-C7)-alkoxy- or arylalkoxy- (preferably with phenylalkoxy-) groups, or means (C3-C10)-cycloalkyl-(C1-C7)-alkyl wherein cycloalkyl is unsubstituted or substituted with one or more halogen atoms, (C1-C7)-alkyl, (C1-C7)-alkoxy-groups; R2 means hydrogen atom (H), halogen atom, (C1-C7)-alkyl, (C1-C7)-alkoxy-; R3 means carboxyl, tetrazolyl, and to their pharmaceutically acceptable salts. Compounds of the formula (I) elicit antihistaminic and anti-allergic activity that allows their using in composition used for treatment of allergic diseases including bronchial asthma, rhinitis, conjunctivitis, dermatitis and nettle rash. Also, invention describes methods for preparing compounds of the formula (I).

EFFECT: valuable medicinal properties of compounds.

15 cl, 2 sch, 3 tbl, 162 ex

FIELD: medicine, pharmaceutical industry.

SUBSTANCE: invention proposes a preparation for regulation of respiratory organs function that is based on medicinal plants. The preparation comprises licorice roots dry extract, ginger milled roots, dry concentrates of creeping thyme herb and colt's foot leaves infusions, milled parmelia, hyssop herb dry concentrate, sage herb infusion dry concentrate, oat, ascorbic acid and accessory substances (starch, calcium stearate, sugar) taken in the definite ratio. The preparation is made as tablet with mass 0.55 g. The preparation promotes to effective regulation of respiratory organs function and elicits the expressed general tonic effect. The proposed preparation is used as an accessory agents promoting to regulation of function of respiratory organs.

EFFECT: valuable medicinal properties of supplement.

2 tbl

FIELD: medicine, pulmonology.

SUBSTANCE: one should perform lovage in three stages:during the 1st stage one should carry out lovage of tracheoalveolar tree for 3-4 min with 60-80 ml 0.08%-sodium hypochlorite solution, at the 2nd stage one should introduce 5-7 ml 10%-fluimucyl solution into tracheobronchial tree for 4-6 min, and at the 3d stage one should perform lovage of tracheobronchial tree for 3-4 min with 60-80 ml 0.11%-sodium hypochlorite solution. The present innovation favors secreta release of decreased viscosity into large bronchi that simplifies its evacuation and this, in its turn, simplifies the access of antiphlogistic and antibacterial preparations towards tracheobronchial tree's mucosa that leads to interrupting inflammatory process in more shortened terms.

EFFECT: more prolonged period of remission.

2 ex

FIELD: medicine, intensive therapy, resuscitation.

SUBSTANCE: along with conventional therapy one should apply serotonin adipinate, 10-500 mg of its solution should be intravenously injected at the rate of 10-30 mg/h. Injection should be repeated during 10-14 d. The method provides improved function of smooth muscle cells of pulmonary vessels by increasing efficiency of oxygenation in this category of patients.

EFFECT: higher efficiency.

1 cl, 2 ex, 1 tbl

FIELD: medicine.

SUBSTANCE: invention proposes agent for suppression of snores noise designated for intramuscular administration. Agent comprises the highly purified clostridium toxin BONT/A or highly purified clostridium toxins BONT/B, BONT/C1, BONT/D, BONT/E, BONT/F and/or BONT/G. Also, agent can be used comprising a fused protein that involves light subunit of clostridium toxins among the group BONT/A, BONT/B, BONT/C1, BONT/D, BONT/E, BONT/F, BONT/G, TeNT, and heavy subunit of another clostridium toxin from the same group, or mixture of fused proteins, or complex comprising clostridium toxin or a fused protein, and one or more therapeutically good tolerable hemagglutinin, and/or one or more pharmaceutically good tolerable nontoxic protein. The proposed therapeutic agent expands assortment of medicinal agent used in the snore therapy. Invention can be used for suppression of snore noise.

EFFECT: enhanced effectiveness of agent.

10 cl, 3 ex

The invention relates to organic chemistry and can find application in medicine

The invention relates to the pharmaceutical field, in particular, to the development of drugs, and can be used for treatment of bronchial asthma

The invention relates to the pharmaceutical industry and is used as an aid in the complex treatment of diseases of the upper respiratory tract

The invention relates to pharmaceutical

FIELD: medicine, gastroenterology, parapharmaceutical industry, phytotherapy.

SUBSTANCE: invention relates to industry manufacturing preparations for curative and prophylactic aims and can be used for prophylaxis and accessory treatment of digestion organs disease, in particular, diseases of pancreas. Invention proposes the preparation for prophylaxis and maintenance drug therapy in treatment of pancreas diseases in the tableted form based on medicinal plants. Invention proposes the preparation comprising dry concentrates of decoctions prepared from elecampane roots, burdock roots, barberry fruits, thyme seeds, flax seeds, buckwheat milled seeds, ascorbic acid, calcium gluconate, starch, calcium stearate and sugar taken in the definite ratio of components. Invention is directed for expanding assortment of medicinal agents used for therapy and prophylaxis of functional disorders in digestion tract function. The preparation exerts an astringent, antiseptic, moderate spasmolytic and analgetic effect, it normalizes acidity of gastric juice and improves digestive processes.

EFFECT: valuable medicinal properties of preparation.

1 tbl

FIELD: medicine, gastroenterology.

SUBSTANCE: invention relates to methods for treatment of chronic helicobacter pylori-associated gastritis. Method is carried out by monotherapy with the probiotic "Laminolakt" in the dose 3 dragees per 24 h for 1 month. Method provides elimination of Helicobacter pylori cells on the background of activation of the immune response in stomach mucosa by effect on microflora and the colon intestine immune system.

EFFECT: enhanced effectiveness of treatment.

2 tbl, 1 ex

FIELD: prophylactic medicine.

SUBSTANCE: one should supplement the diet of preschool children with the extract of reindeers' velvet antlers "Epsorin" per 10 drops twice in the first half of the day for 20 d. The innovation enables to restore normal microflora in large intestine due to washing out pathogenic bacteria from intestinal tract and stimulation of lacto- and bifidobacteria.

EFFECT: higher efficiency of intestinal microflora normalization.

2 tbl

FIELD: medicine.

SUBSTANCE: method involves introducing cauterizing necrotizing composition like paste containing silver nitrate and dextrane into uterine cavity. Paste contact to target tissue is supported during time enough for reaching chemical necrosis. Then cauterizing composition is brought in contact with deactivating agent like aqueous solution of sodium chloride and removed from the uterine cavity later on. It is proposed to protect non-target tissue by supplying protection agent to it and carrying out previously described steps.

EFFECT: enhanced effectiveness of cauterization controlled in time and action intensity degree; avoided other tissue injuries.

30 cl, 8 dwg

FIELD: medicine, pulmonology.

SUBSTANCE: one should apply lycopid to study initial level of mature T-cells (CD3+) in % and solve following discriminant equation: D = 0.840 · (CD3+), and at D value being above 29.24 one should predict positive curative effect as a result of lycopid application, and at D value being below 29.24 on should predict no positive curative effect.

EFFECT: higher efficiency of lycopid-including therapy.

2 ex

FIELD: medicine.

SUBSTANCE: method involves administering selective modulator of steroid sex hormones being in particular compounds of general formula(I) and some quantity of steroid sex hormones precursor selected from a group composed from dehydroepiandrosterone, dehydroepiandrosterone sulfate, androst-5-en-3β,17β-diol and compounds in vivo transformable into one of cited precursors. Bisphosphonates combined with selective estrogen receptor modulators and/or steroid sex hormones precursor are additionally introduced for medically treating and/or inhibiting osteoporosis progress.

EFFECT: enhanced effectiveness of treatment; excluded adverse side effects.

41 cl, 13 dwg, 4 tbl

FIELD: medicine.

SUBSTANCE: method involves administering selective modulator of steroid sex hormones being in particular compounds of general formula(I) and some quantity of steroid sex hormones precursor selected from a group composed from dehydroepiandrosterone, dehydroepiandrosterone sulfate, androst-5-en-3β,17β-diol and compounds in vivo transformable into one of cited precursors. Bisphosphonates combined with selective estrogen receptor modulators and/or steroid sex hormones precursor are additionally introduced for medically treating and/or inhibiting osteoporosis progress.

EFFECT: enhanced effectiveness of treatment; excluded adverse side effects.

41 cl, 13 dwg, 4 tbl

FIELD: pharmaceutical industry.

SUBSTANCE: invention provides therapeutical formulation for improving fertility and treating sterility caused by polycystic ovary syndrome, which composition is characterized by that formulation thereof involves use of dipeptidylpeptidase IV inhibitor. Treatment of polycystic ovary syndrome-caused sterility is high successful with effective active ingredient concentration equal to 1 μM. When dipeptidylpeptidase IV inhibitor is administered, luteinizing hormone and testosterone levels in blood are normalized. Claimed compounds are low toxic for warm-blooded animals and humans.

EFFECT: widened choice of efficient antisterility drugs.

7 cl, 3 ex

FIELD: organic chemistry, medicine, chemical-pharmaceutical industry, pharmacy.

SUBSTANCE: invention relates to the development of agents eliciting anti-hypoxic and antioxidant activity. Invention proposes an agent "Spirofen" of the general formula: C6n+6H4n+5NaO2n+5S2 that comprises a mixture of sodium salts of 5 sulfonylthio-derivatives of 2,2'-bi-, 2,2' : 3',2''-tri-, 2,2' : 3',2'' : 3'',2'''-tetra-, 2,2' : 3',2'' : 3'',2''' : 3''',2''''-penta- and 2,2' : 3',2'' : 3'',2''' : 3''',2'''' : 3''''-hexahydroqionones. Agent is prepared as powder, tablet, solution, capsule or emulsion. Invention provides expanding spectrum of the pharmacological effect and enhanced effectiveness in its applying.

EFFECT: valuable medicinal properties of agent.

3 cl

FIELD: medicine, toxicology.

SUBSTANCE: the present innovation deals with the ways to inhibit toxins in animals and people in case of gastro-intestinal tract (GIT) disease. One should introduce therapeutically efficient quantity of polymer that has several lateral acidic functional groups attached directly to the main chain of polymer or being connected with it due to intermediate group. The latter could have the chain of 0-20 atoms length. Toxin is usually being exotoxin secreted by pathogenic microorganisms, such as bacteria, for example in case of diarrhea. The method enables to widen the quantity of preparations applied in case of bacterial GIT lesions.

EFFECT: higher efficiency.

39 cl, 2 dwg, 23 ex, 1 tbl

FIELD: medicine, gastroenterology, parapharmaceutical industry, phytotherapy.

SUBSTANCE: invention relates to industry manufacturing preparations for curative and prophylactic aims and can be used for prophylaxis and accessory treatment of digestion organs disease, in particular, diseases of pancreas. Invention proposes the preparation for prophylaxis and maintenance drug therapy in treatment of pancreas diseases in the tableted form based on medicinal plants. Invention proposes the preparation comprising dry concentrates of decoctions prepared from elecampane roots, burdock roots, barberry fruits, thyme seeds, flax seeds, buckwheat milled seeds, ascorbic acid, calcium gluconate, starch, calcium stearate and sugar taken in the definite ratio of components. Invention is directed for expanding assortment of medicinal agents used for therapy and prophylaxis of functional disorders in digestion tract function. The preparation exerts an astringent, antiseptic, moderate spasmolytic and analgetic effect, it normalizes acidity of gastric juice and improves digestive processes.

EFFECT: valuable medicinal properties of preparation.

1 tbl

Up!