The hemostatic tool

(57) Abstract:

The invention relates to the field of medical pharmacology, namely organic geostatical used to stop the capillary and mixed hemorrhage in traumatic lesions of the skin and muscle tissue in surgical practice. The hemostatic tool consists of calcium alginate and ranozazhivlyayuschim and antiseptic additives, such as a plant extract of oak bark, dry plant extracts, -aminocaproic acid and chlorhexidine. 1 PL.

The invention relates to the field of medical pharmacology, namely organic geostatical used to stop the capillary and mixed hemorrhage in traumatic lesions of the skin and muscle tissue in surgical practice.

Known analogues of hemostatic drugs: hemostatic sponge and gelatin (guidance on the use of blood and blood substitutes, Medicine, 1973). The analogs may include fibrin sealants, glues, pastes, such as fibrin glue for U.S. patent No. 5773418 from 20.11.1998, that uses adjuvant as antibiotic, antitumor agent, antagonist antihistamine H2, fibranet the rat "Alkitab" company "omega" (the prospectus of the company "omega", Russia).

The disadvantages of the above drugs are complex compositions of drugs, expensive structure.

The closest adopted for the prototype is a domestic product "Zhelplastan" (Author's certificate of the Russian Federation No. 725289 from 31.07.1975 year).

Well-known medication contains plasma of cattle, gelatin and the antibiotic kanamycin sulfate. He has a hemostatic effect, however, of the active substance components of the drug during the technological cycle are deactivated, the blood plasma of cattle entered in its composition in the finished dosage form, on the hemostatic properties of the drug has virtually no effect. Antibacterial component is not valid. The hemostatic properties of the drug are mainly determined by gelatin powder, which is structured in a certain way during the process, but is practically insoluble, which impairs its adhesive properties (especially in the first application).

The purpose of this invention is the improvement of hemostatic, wound healing effect and achievement antiseptic action. Proposed drug, organic hemostatic powder foes for harmful actions, hypoallergenic, there are no viruses pathogens dangerous to humans infections, because the drug is used only raw materials of plant origin and synthetic components. The hemostatic product contains calcium alginate, dried phyto-extracts: oak bark, yarrow, herbs St. John's wort, horsetail grass, nettle leaves, Epsilon-aminocaproic acid, chlorhexidine at a ratio of components, wt.%:

Alginate calcium 68,4-73,4

Extract of oak dry 16,5-21,5

Yarrow extract dry 1

St John's wort dry 1

Horsetail extract dry 1

The nettle extract dry 1

Epsilon-aminocaproic acid 6

Chlorhexidine 0,1

The calcium alginate is used as the basis of the preparation and role of the matrix in the formation of thrombi. To improve the hemostatic properties to the drug add the extract of oak bark, and to improve wound healing, anti-inflammatory, antiseptic properties of the herbal extracts.

Upon contact of the drug with bleeding particles of calcium alginate close the wound surface, taking its shape without causing trauma to the surrounding tissue. They reinforce the by platelets. Calcium ions polysaccharide base stimulates the process of thrombus formation. Due to tannins, covering particle basis, the strengthening of blood clots and their adgezirovannah to the wound surface, and each other. Having a large surface area and good adsorption properties, powder foundations quickly soaked bleeding. This increases the concentration of tambourissa substances on their surface. Partial immobilization of polysaccharide-based active substances of the components of the drug reduces its toxicity and Allergy, and also provides a prolonged effect.

So, oak bark extract causes direct coagulation of plasma proteins that provides rapid thrombus formation and good adhesion of the particles of the basics. It causes compaction of the surface layer of tissue on the wound surface reduction of permeability due to non-specific physico-chemical changes of colloids cells and extracellular fluid. Thus forming a dense protective film, which protects the tissue from exposure to irritating substances, reducing pain, contributing to the narrowing of the capillaries and seal blood vessels.

Epsilon-aminocaproic is its premature destruction by plasmin, and stabilizes the fibrin clot over a long period.

Chlorhexidine, being one of the most active local antiseptics, providing a quick and strong bactericidal effect on pathogens of major wound infections. It is stable after his wound and stored it, continuing to exert a bactericidal effect. Chlorhexidine retains activity in the presence of blood. The introduction of the antiseptic component in the drug became relevant, as it makes possible the use of the drug without prior antiseptic treatment of wounds, which is important in the extreme and military field conditions.

Extracts of yarrow, St. John's wort, horsetail and nettle stimulates reparative processes in the wound.

After application of the drug on the surface of the wound its active ingredients are dissolved in the flowing blood and provide hemostatic and wound healing effect.

The proposed remedy is prepared as follows. Take powder of calcium alginate in number to 68.4 g, add 6 g of aminocaproic acid, dissolved in 200 ml of chlorhexidine, a suspension of a 21.5 g of dry oak bark extract and 200 ml of 95% ethyl alcohol. From the resulting CME is intova mixture. The drying process should not exceed 4 hours. To the resulting semi-finished product admixed dry extracts of yarrow, St. John's wort, horsetail, nettle. The resulting brown powder Packed in sealed packages of moisture-proof and light-proof material.

A series of works (selection of a new framework of the preparation, selection of components, development of technological process), which allows to significantly increase the hemostatic effect. When conducting a series of tests of hemostatic activity means the time of hemostasis (s) was reduced by at least 30% compared with the norm (see table).

Thus, the proposed facility can achieve a higher hemostatic and wound healing effect. All components of the hemostatic agents are available and are produced in Russia. The technology for this hemostatic simple, does not require the use of toxic substances, is implemented in small areas and uses little pieces of equipment that significantly reduces the cost of the drug compared with domestic and foreign counterparts.

The hemostatic agent containing wound healing and antiseptic additives and the basis of the s oak yarrow, St. John's wort, horsetail, nettle and additionally Epsilon-aminocaproic acid and chlorhexidine in the following ratio, wt.%:

Alginate calcium 68,4-73,4

The oak bark extract dry 16,5-21,5

Yarrow extract dry 1

St John's wort dry 1

Horsetail extract dry 1

The nettle extract dry 1

Epsilon-aminocaproic acid 6

Chlorhexidine 0,1