The treatment for scabies (options)

 

(57) Abstract:

The invention relates to the field of pharmaceutical industry and relates to means for the treatment of scabies. The invention lies in the fact that one part contains codecamp, benzylbenzoate, vangeluwe oil, butylacetyl and sunflower oil, and the other is a benzyl benzoate, benzocaine, tween-80, purified water. The invention provides a receiving means having antiparasitic, ulozenym, analgesic effect, not providing local irritation, allowing you to shorten the time of treatment of the disease. 2 N. p. F.-ly, 6 PL.

The invention relates to medicine, in particular to pharmacology, and relates to means for the treatment of scabies.

Known antiparasitic agent that is obtained by extraction of the nut with green pericarp milk ripeness with refined kerosene when the ratio of raw material and extractant from 1:0.8 to 1.0:1.5 by adding oil to the total content of fatty oils in the final product 11% (RF Patent No. 2136304, a 61 K 35/78 priority 10.09.99.).

The disadvantage of this tool is the availability of local irritation at the 24-hour skin contact.

WPI Is 0 (Mashkovsky M. D. Medicinal product. - 1988. - 10th ed. - T. 2. - P. 392), used for the treatment of scabies.

The disadvantage of this structure is the lack of bocenago, antimicrobial, anti-inflammatory and analgesic actions, feeling burning sensation when applied.

The objective of the invention is to provide means for the treatment of scabies with ulozenym and analgesic effects, it doesn't affect local irritation, allowing you to shorten the treatment of scabies.

The problem is solved by treatment for scabies containing benzyl benzoate, codecamp, benzocaine, essential vangeluwe oil, butylacetyl, sunflower oil in the following ratio, wt.% (part 1):

Codecamp 10,0-15,0

The Benzyl Benzoate Of 20.0 To 15.0

Benzocaine 1,9-2,1

Essential vangeluwe oil 0,38-0,42

Butylacetyl 0,1

Sunflower oil To 100.0

and means containing benzyl benzoate, benzocaine, tween-80, purified water, in the following ratio, wt.% (part 2):

The Benzyl Benzoate 19,4-20,6

Benzocaine 1,9-2,1

Tween-80 3,0

Purified water Up to 100.0

The combination of these comp-technological research.

The process of obtaining the means of structure 1 consists of the following stages: preparation of the material, the dissolution of ingredients by heating, mixing, filling and packaging.

Cited specific examples of the preparation of the described compositions.

Example 1. Protivochesotocnaya composition 1, containing, g:

Codecamp 10,0

The Benzyl Benzoate 20,0

Benzocaine 1,9

Essential vangeluwe oil 0,38

Butylacetyl 0,1

Sunflower oil To 100.0

In a mixer with steam jacket placed 67,62 g of sunflower oil, add 0.1 g of butylacetyl, 20,0 g of benzyl benzoate and the mixture is heated with stirring to 70°C, dissolve in it and 1.9 g of benzocaine, then cooled to a temperature of 40°C. Enter 10.0 g of codecamp and 0.38 g penhelig oil.

The tool structure 1 is a light yellow oily liquid characteristic odor.

Ready-made tool standardizes Packed on 25,0-50,0 g in orange glass bottles with screw-on lid.

Example 2. Protivochesotocnaya composition 1, containing, g:

Codecamp 15,0

The Benzyl Benzoate 15,0

Benzocaine 2,1

Essential fenhelevoe the introduction of ingredients corresponds to example 1. The tool itself is a light yellow oily liquid characteristic odor.

Ready-made tool standardizes Packed by 25.0 g 50.0 g in orange glass bottles with screw-on lid.

Example 3. Protivochesotocnaya composition 2 containing, g:

The Benzyl Benzoate 19,4

Benzocaine 1,9

Tween-80 3,0

Purified water Up to 100.0

The process of obtaining funds part 2 consists of the following stages: preparation of the material, the dissolution of ingredients when heated, emulsification, filling and packaging.

In a mixer put to 19.4 g of benzyl benzoate, heated to 70°C, dissolve in it and 1.9 g of benzocaine, add 3.0 tween-80, part purified water, preheated to 70°C, and emuleret when the rotation speed of the stirrer 1500 rpm for 4 minutes, then enter the remaining amount of water, continuing emulsification until the emulsion at room temperature.

The tool part 2 is a liquid milky white in color with a characteristic smell of benzyl benzoate.

Ready-made tool standardizes Packed in 50.0 g in orange glass bottles with screw-on lid.

Example 4. the h-80 3,0

Purified water Up to 100.0

The sequence of the introduction of ingredients corresponds to example 3. The tool part 2 is a liquid petty-white in color with a characteristic odor of benzyl benzoate.

Ready-made tool standardizes and pack up analogously to example 3. Study of the effectiveness of the means of compositions 1 and 2 for the treatment of scabies was carried out on the basis of sanitary point of disinfection station №2, Moscow.

Example 5. Pharmacological action protivochesotocnaya tools part 1

The drug was tested for 4 months on volunteers. Treated 47 patients with scabies different degree of infestation, the characteristics of which are presented in tables 1 and 2.

All patients had clear form lesions of scabies, because they went for treatment after diagnosis by a doctor.

The presence of a strong degree of infestation of scabies skin with severe complications (dermatitis, eczema, pyoderma) was evaluated as 3 points, the average prevalence is 2 points, weak - 1 point.

Tool composition 1 was creeping into the skin after washing the body with soap and water 1 time a day; treatment was carried out for 2 days. Secondary use Provo the elk treatment with a rubbing tool 2 times with an interval of 30 minutes for 2 days.

The main criterion for assessing the effectiveness of tools was subjective data of patients and objective observations obtained during examination of patients on the second and third days of treatment.

Taking into account the effectiveness of the composition in terms of active and egg shape scabby mite.

The best effect was observed with the introduction of codecamp and benzyl benzoate at a total content of 30% and benzocaine is not less than 2%.

Additionally, by application tests the tool was tested for the absence of local irritation, allergic action.

The tool structure 1 for the treatment of scabies, acute dermatitis, eczema, pyoderma, did not cause the dissemination pyoderma, had a soothing, calming, anti-microbial wound healing effect.

Skin side effects: persistent redness (hyperemia), allergic reactions, cases of drug-induced dermatitis on the used tool is not marked. Treatment patients tolerated easily noted analgesic and sedative action, the lack of a sense of burning and tingling sensation on the areas of excoriation.

Complications of a General nature and function disorders of the skin during treatment is ogically therapeutic effect in 2-day treatment method registered by 44 people however it is noted ulozeny effect of the means of structure 1.

Five of the 47 patients had a long duration of the disease (more than 1 month) and a severe defeat scabies was observed in 24 patients. 2 days only 3 patients did not come full cure: one person was observed instead of the strong prevalence - average and two man - weak expression of the disease. Positive therapeutic effect registered by 93,6% of treated patients. To confirm bocenago action tools of composition 1 in 6 patients (men's) observation was carried out for 14 days. The results of the study bozicnik properties means 1 are shown in table 3.

Presents data in a two-week surveillance of patients testify to the effectiveness of the structure 1 as bocenago protivochesotocnaya means during a two-day treatment method.

Example 6. Pharmacological action protivochesotocnaya tools part 2

The drug was tested for 4 months on volunteers. Treated 48 patients with scabies different degree of infestation, the characteristics of which are presented in tables 4 and 5.

All patients had clear form lesions of scabies the particular scabies skin with severe complications (dermatitis, eczema, pyoderma) was evaluated as 3 points, the average prevalence is 2 points, weak - 1 point.

Composition 2 was creeping into the skin after washing the body with soap and water 1 time a day; treatment was carried out for 2 days. A second treatment means were carried out on the second day after washing the body with soap and water.

When there is a strong degree of destruction scabies were treated with a rubbing tool part 2 two times with an interval of 30 minutes for 2 days.

The main criterion for assessing the effectiveness of tools part 2 served subjective data of patients and objective observations on the second and third days of treatment.

Take into account the effectiveness of the composition 2 for active and egg shape scabby mite.

In addition to the clinical criteria conducted clinical studies of a new means of composition 2. By application tests the tool was tested for the absence of local irritation, allergic action.

The tool part 2 for the treatment of scabies, acute dermatitis, eczema, pyoderma, did not cause the dissemination pyoderma, had a soothing, calming effect.

Skin side effects: persistent redness (hyperemia. After treatment by means of part 2 of the complications of a General nature and disorders of the skin were observed; intolerance patients investigational product is not registered.

Patients reported analgesic and sedative action tools of composition 2, the lack of a sense of burning and tingling sensation on the areas of excoriation. Complications of a General nature and function disorders of the skin during treatment were observed. There was no single case of individual intolerance of the test tools.

Positive therapeutic effect with ulozenym action at the 2-day treatment method registered by 45 people.

Eight patients out of 48 had a long course of the disease (>1 month) and a severe defeat scabies - 22 people. 2 days only 3 patients did not come to a complete cure. Positive therapeutic effect was registered in 93, 75% of treated patients. To confirm bocenago action tools of composition 2 in 6 patients (men's) observation was carried out for 14 days.

The results of the study bozicnik the aphrodisiac properties of composition 2 shown in table 6.

Presents data in a two-week surveillance of patients SVID is Tode treatment.

1. The treatment for scabies on the basis of benzyl benzoate, characterized in that it further comprises codecamp, benzocaine, vangeluwe oil, butylacetyl, sunflower oil under the following ratios, wt.%:

Codecamp 15,00-20,0

The Benzyl Benzoate 15,0-10,0

Benzocaine 1,9-2,1

Vangeluwe oil 0,38-0,42

Butylacetyl 0,1

Sunflower oil 100

2. The treatment for scabies on the basis of benzyl benzoate and water purified, characterized in that it additionally contains benzocaine and tween-80 in the following ratios, wt.%:

The Benzyl Benzoate 19,4-20,6

Benzocaine 1,9-2,1

Tween-80 3,0

Purified water Up to 100.0



 

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