A means to combat bacterial diseases of bees |
|
|
IPC classes for russian patent A means to combat bacterial diseases of bees (RU 2121789):
 Derivatives hinolincarbonova acids or their pharmaceutically acceptable salts / 2120941
The invention relates to new derivatives hinolincarbonova acids of the formula I, their pharmaceutically acceptable salts and their hydrates
 N-substituted derivatives of 3-azabicyclo(3,2,0)-heptane and their salts with physiologically tolerated acids / 2120439
The invention relates to new N-substituted derivatives of 3-azabicyclo[3.2.0] -heptane and its salts with physiologically tolerated acids, possessing neuroleptic activity
 Aryl-condensed 2,4-diazepinone compounds, intermediates, anti-arrhythmic agent and composition / 2114833
The invention relates to novel 4,5-dihydro-1H-2,4-allowin the benzodiazepines and benzodiazipine appropriate diamines and aminoamides, to methods for their preparation and to methods and compositions for treating arrhythmia in mammals with said 4,5-dihydro-1H-2,4-ariovich of benzodiazepines and benzodiazipines
 Derivatives of 7-isoindoline and 7 - sonderedition / 2111964
The invention relates to derivatives of 7-isoindoline and 7-sonderedition, which can be used in medicine, as manifesting a strong antibiotic activity with slight toxicity
 Oxopropanenitrile derivatives of condensed pyrazole or their pharmaceutically acceptable salts, manifesting immunostimulirutuyu activity, and pharmaceutical composition / 2109735
The invention relates to 3-oxo-propanenitrile derived condensed pyrazole, method of production thereof and to pharmaceutical compositions containing them
 Derivatives of 1-aryl-5-(substituted methylidene)pyrazole, method of combating harmful insects and insecticidal composition / 2088576
The invention relates to new 1-aryl-5-(substituted)alkylidene the pyrazoles, methods for their preparation, to compositions containing these compounds, to methods of their use for combating arthropods, nematodes, helminths or protozoa pests
 Dihydropyridine derivatives or their pharmaceutically acceptable salts and pharmaceutical compositions on their basis / 2086548
The invention relates to imidazolium and pyridium derived phenylsilane 1,4-dihydropyridines, to the way they are received and containing pharmaceutical compositions
 The way to fight ascosphaerosis bees / 2075293
The invention relates to methods of combating ascosphaerosis bees and can be used on apiaries
 The way to combat varroa bee / 2058731
The invention relates to veterinary medicine, namely to search for new means of protecting bees from parasites, in particular from ticks, varroa jacobsoni
A method of treating bees with fungal diseases / 2052246
The invention relates to beekeeping and can be used for the treatment of fungal diseases of bees, such as Ashteroth
Preparation for treating ascospherosis in bees / 2249349
The suggested preparation to treat ascospherosis in bees contains, weight%: nystatin 26-32, thymol 5-9, atox 54-60, furacillin 5-9. The present innovation enables to broaden the number of preparations of high curative action.
|
(57) Abstract: To improve the efficiency as a means to combat bacterial diseases of bees using 1-ethyl-6-fluoro - 7(4-methylpiperazine)-4-oxo - 1,4-dihydro-3-quinoline-carboxylic acid. The tool reduces the resistance of bacterial pathogens and thereby increases the resistance of bees to viral and fungal diseases by 30 %. The invention relates to agriculture, in particular animal, and can be used to combat bacterial diseases of bees. You know the way to combat bacterial diseases of bees, in particular the antibiotic kanamycin (instructions on the measures for the prevention and eradication of contagious diseases of bees. Decl. The BS of the Ministry of agriculture of the USSR 27.12.84-N115-6a, page 7). However, the known means are not effective enough, cause when using the frequent recurrence of the disease, increasing the resistance of strains of pathogens. A method of obtaining 1-ethyl-6-fluoro-7-(4-methylpiperazine)- 4-oxo-1,4-dihydro-3-quinoline-carboxylic acid, trade name - perfloxacin (patent 1766921 USSR, MKI 5 C 07 D 401/04, B 37, 1992). Used pefloxacin in medicine as an antibacterial agent. The purpose of the Executive and the incidence of fungal and viral diseases in the treatment of bacterial diseases of bees, simplify the process of combating bacterial diseases of bees. This goal is achieved by the fact that as a means to combat bacterial diseases of bees using 1-ethyl-6-fluoro - 7(4-methylpiperazine)-4-oxo - 1,4-dihydro-3-quinoline-carboxylic acid. In the patent and scientific literature unknown solutions similar stated, i.e., the proposal meets the criterion of "novelty". The proposal also meets the criterion of "industrial applicability" because the claimed tool produced by the domestic industry. We first established that the use of pefloksatsina allows you to get a new positive effect simplifies the process of combating bacterial diseases of bees, reduces the incidence of bees fungal and viral diseases of bees on the background of bacterial diseases, i.e., the proposal meets the criterion of "inventive step". Not all antibiotics used in medical practice, can be used in beekeeping. For example, bicillin, ampicillin in beekeeping practice is not used, despite their high antibacterial activity as the causative agents of bacterial diseases of bees were not sensitive to dannie American hnilica (Bac. larvae), 2 ml of a 5% solution pefloksatsina add to 1 litre of sugar syrup (1 : 1). For the experiment were selected twenty families of bees, on the principle of analogues based on their strength, korvalainete, the degree of infestation of larvae pathogens American hnilica, health and age of Queen bees. Sugar syrup with pefloxacin were fed ten bee families in the feeders is based 80 - 100 ml per lane bees twice with an interval of four days. Ten control families were fed daily for 7 days sugar syrup (1 : 1) containing kanamycin, according to the instructions. Counting dying larvae was carried out according to the usual method, and determined the microbial, fungal and viral composition according to Methodical instructions for laboratory diagnosis of bacterial diseases of bees (1986). The analysis of the obtained results revealed that full recovery of bee colonies in the experimental group occurred after five days, while in the control - seven, i.e., approximately 30% of the treatment time of the American hnilica reduced when using pefloksatsina. Subsequent observation treated with pefloxacin and kanamycin bee colonies by piperylene (2 families) and saccular brood (1 family), i.e., after treatment with kanamycin, as a complication, occurred the development of fungal diseases in 50% and 10% of the virus; in the experimental group fungal and viral diseases have not been identified;the relapses were noted in four control families (40%), while in the experienced bee colonies recurrence was found. The simplification of the treatment of American hnilica resulted in the reduction of the feeding of bee colonies in 3.5 times. In addition, prepared treatment solution pefloksatsina stable and does not require daily preparation. Example 2. To ensure European hnilica (Bac. alvei) 1 ml of a 5% solution pefloksatsina add to 1 litre of sugar syrup (1:1). For experimental and control groups consisted of 20 bee colonies (10 families in each group) analogously to example 1. Sugar syrup with pefloxacin were fed bee families in the feeders is based 80 - 100 ml per lane bees twice with an interval of 5 days. Control families were treated with kanamycin daily for 7 days (see example 1). Counting dead larvae was carried out according to the usual method, was determined microbial, fungal and viral structures (see example 1). In estupro for 5 days; in the control group (treatment with kanamycin), despite medical treatment, in two bee colonies remained clinic European hnilica; in the control families were identified diseases: ascosphaerosis (2 families), aspergillosis (2 families), i.e., after treatment with kanamycin, as a complication, occurred the development of fungal diseases in 40% of the bee colonies; in the experimental group of fungal and viral diseases has not been identified; relapses were observed in three control families (30%), experienced families of recurrence was not detected. The simplification of the treatment of European hnilica resulted in the reduction of the feeding of bee colonies in 3.5 times. In addition, prepared treatment solution pefloksatsina stable and does not require daily preparation. Example 3. For the treatment of colibacillosis bees mixed with 0.5 parts by weight of pefloksatsina from 0.05 parts water, 1 part of honey and 4 parts powdered sugar. Thus prepared medical dough - Kandy - fed bee families at the rate of 0.5 kg per family. For experimental and control groups consisted of 20 bee colonies (10 families in each group) analogously to example 1. The control group were fed Kandy with kanamycin when the PLO within 3 days and in the control group to 7 days from the beginning of the treatment, i.e. the treatment time was reduced by 60%. Thus, in the treatment of bacterial diseases of bees by pefloxacin treatment time reduced by 30 - 60%, reduced relapses by 30 - 40%, decrease complications such as fungal (40 - 50%) and viral (10%) diseases. In addition, it simplifies the technology of combating bacterial diseases of bees. The use of 1-ethyl-6-fluoro-7(4-methylpiperazine)-4-oxo-1,4-dihydro-3-quinoline-carboxylic acid as a means to combat bacterial diseases of bees.
|
