Water-soluble bactericidal reparative composition

FIELD: chemistry.

SUBSTANCE: composition includes a bactericidal substance - catapol - in amount of 2.1-2.5 wt %, zosterin in amount of 1.1-5.0 wt % and distilled water.

EFFECT: providing a composition which stimulates a reparative process in external protective tissue, having anti-inflammatory and radioprotective action.

1 tbl, 1 ex

 

The invention relates to medicine, veterinary medicine, namely to the field result they have proved, dermatology, surgery, and is used for treatment and prevention of diseases and complications in humans and animals.

It is known the use of compositions as wound healing, dermatological products containing antiseptics, stimulators of tissue metabolism.

Known composition to stimulate repair of the skin (wounds), containing (wt.%): collagen farm animals 0,2-1,5; sulfated glycosaminoglycans of 0.002 to 0.05; water-soluble derivatives of cellulose of 0.05-2.5; water - the rest [EN 2092156, A61K 9/08, A61K 35/32; 10.10.1997].

A significant drawback of analogue is that the composition may cause allergic reactions because it is composed of the protein collagen.

The closest vehicle to the present invention is antiseptic [EN 1517173, A61K 31/14, 30.04.1997], which relates to antimicrobial compositions, contains the antiseptic katapola, sodium chloride, and water in specific proportions. The General features of the proposed and known means is used in both cases katapola as a bactericidal substance.

The disadvantages of the prototype: in the presence of antimicrobial activity of the drug has a mild reparative properties that can the t adversely affect the healing time of wounds and restoring the active life of the individual.

The technical task and the positive result of the invention is to provide a multifunctional tool to accelerate the healing of lesions of epithelial tissue and superficial wounds in all stages of the healing process of wounds, particularly burns of various etiologies, including radiation, as the most severe lesions of the skin, combined lesions. The inventive composition has the following distinctive features in the application: reduced duration of the latent period, the acceleration of the completion of the inflammatory period, early deadlines and shortening of the period of the formation of the epithelium, decrease or absence of period suppurative inflammation and lack of toxicity and allergenicity.

The problem is solved by obtaining a composition containing the following ingredients: as biologically active substances with reparative activity component related to the pectins obtained from marine plants of the family "Smolnikova" (Zosteraceae) - Zosterin (trade names: Zosterin, Zosterin ultra 30, Zosterin ultra 60, isosteric); katapola - antiseptic broad-spectrum (exhibits bactericidal activity against staphylococci, streptococci, gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa, Proteus, Klebsiella and others), has also protiveris the TV and virucidal activity (inactivates virus Herpes simplex); distilled water - up to 100 in the following mass ratios, wt%:

Zosterin1,0-5,0
The katapola0,1-5,0
distilled waterrest

The composition of the claimed composition was confirmed by standard methods.

An example of obtaining this composition.

To 94 g of distilled water, heated to 70°C, add 1 g of powder Zosterin and dissolved under stirring for 1.5-2 hours. After cooling to room temperature, to the resulting solution add 5 ml of 10% solution of the drug katapola and stirred for 1 hour to complete matching of components.

The effectiveness of the claimed compositions were evaluated in the experiments, put on white rats-males weighing 200-240 g model treatment of radiation injury III-a degree. For studies used healthy animals with clean skin, past the quarantine for 14 days. 1 day before the experiment at the proposed site of the skin of the back of the animals was removed hair with warm 15% solution of sodium sulphide, if necessary used method of hair removal skin of the animal.

Before irradiation of the skin of the animal is fixed in a horizontal position on a specially designed jig.

Radiation damage to the skin was modeled irradiation area nepilirovanny back skin of rats from a source of soft x-ray radiation to the installation PART 17 when the voltage on the tube 180 kV, anode current of 15 mA, the filter 1 mm Cu+1 mm A1, dose rate 52 R/min, skin-focal length 10 cm radiation Dose to the skin was 58 G, field exposure of 1.7×1.7 cm2. The body of the animal during irradiation of the skin was protected with lead plates with a thickness of 2 mm All investigated solutions was applied immediately after irradiation of the skin and continued to apply once daily (in the morning) during the whole period of healing beam ulcers until epithelialization of the skin to the detachment of the crust and restore the skin. As shown by experimental studies, all studied compounds were non-toxic, had no local irritating effect and was well tolerated by the animals with long-term local application.

Estimated visual indications of the formation of radiation damage to the skin: the appearance and severity of signs of inflammation at the site of exposure skin hyperemia (redness), scaling, swelling, duration of the inflammatory period and the formation of focus of radiation skin lesions (ulcers, covered with a dry crust). Reparative processes (healing local radiation injury) estimated p is the period of wound healing (terms detachment of crusts), the duration and intensity of wound healing. The intensity of wound healing was assessed by the index of wound healing, as defined by generally accepted metric - speed the healing of wounds.

Comparative data on the effectiveness of treatment of radiation injuries of the skin of animals (rats) solutions Kosterina, katapola and their compositions are given in the table below:

/tr>
Table
Experience
ing group-
p
The composition of the solutionSigns of radiation injury to the skin (day)Signs of healing of radiation damage to the skin (day)The average speed they healed-
ing ulcers
(% per day)
The timing of the emergence of Patras-
in
Continue
length inflammatory-
tion of period
Terms formed
the formation of crust
(ulcers)
Time they healed-
of ulcers
Length
the activities they healed-
of ulcers
11,0%7.7±0.74.8±0.512.7±2 28.3±2.415.8±2.66.8±1.0
Zosterin
20,5%7.5±024.0±0.512.0±0.429.0±0.816.0±1.26.4±0.5
the katapola
30,5%5.8±0.44.2±0.310.5±0225.2±1.115.0±1.46.8±0.6
the katapolathe
+1,0%
Zosterin
40,1%Without treatment
the katapola
+5,0%
Zosterin
55,0%
the katapola
+1,0%
Zosterin
Without treatment
62,5%6.3±0.42.5±0.28.3±0.328.0±2.320.4±2.55.3±0.7
Zosterin
Control9.3±0.84.7±0.814.7±0.833.0±2.917.5±2.66.1±0.9

Thus, the positive effect of the proposed solutions is that created polyfunctional composition, stimulating the reparative process in epithelial tissues of mammals that have anti-inflammatory, radioprotectors, antimicrobial activity, decreasing the degree of burn injury intended for external application in the form of skin application.

Literature

1. Afinogenov G., Panarin E.F. Antimicrobial polymers, SPb.: Hippocrates, 1993, 261 S.

2. Goncharenko E.N., Kudryashov SHE Radioprotective means of natural origin. The successes of modern biology. 1991, Vol.3, issue 2, s-316.

3. Saksonov P.P., B.C. Hamilton, Sergeev PV Radiation pharmacology. M.: Medicine, 1976, s-217.

4. Kolenchenko E.A., Sonin, L.N., Khotimchenko US Comparative evaluation of antioxidant activity of disketer fitiavana pectins from sea grass zostera marina and drugs antioxidants in vitro. Marine biology, 2005, T. 31, No. 5, s-383.

5. Zaporozhets T.S. Comparative immunological activity polyglycerol of marine origin. Antibiotics and chemotherapy, 2001, T. 46, No. 7, S. 6-10.

5. Vasin MV prophylaxis and treatment of radiation injuries. 2nd ed., supplementary, M, 2001,312 C.

Water-soluble bactericidal reparative composition comprising a bactericidal substance katapola, characterized in that it additionally contains polysaccharide Zosterin in the following ratio, wt.%:

Zosterin1,1-5,0
The katapola2,1-2,5
Distilled waterrest



 

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