Method for preconception preparation in early recurrent miscarriage

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to obstetrics and gynaecology, and may be used for preconception preparation in early recurrent miscarriage caused by chronic genital inflammation or inflammatory hormonal ovarian insufficiency. That is ensured by 12 intravaginal introductions of disposable injectors with Dead sea mud gel as a therapeutic agent daily for 30 minutes within one therapeutic course upon completion of the anti-inflammatory treatment following the early miscarriage.

EFFECT: invention provides 50% higher safety and effectiveness of preconception preparation in the given group of patients.

2 ex

 

The invention relates to medicine, namely to obstetrics and gynecology, may be used as pregravidarnoy preparation for miscarriage in the early weeks of gestation due to chronic inflammation of the genitals or failure of hormonal function of ovaries inflammatory Genesis.

Infectious cause in recent years has identified as one of the main causes of spontaneous and recurrent miscarriage. Long, often asymptomatic persistence of infectious agents in the endometrium leads to pronounced changes in the fabric structure, the receptor apparatus. Chronic endometritis broken processes implantation, placentation, normal pregnancy, leading to its early losses. For miscarriage chronic endometritis reveal more than 70% of cases [4].

Chronic endometritis is one of the reasons for the formation of luteal insufficiency (NLF). Results hormonal tests indicate a defective luteal phase of the cycle, 40% of women with recurrent pregnancy loss pregnancy and regular rhythm of menstruation. Failure of the second phase of the menstrual cycle often accompany: disorders of growth and full maturation of follicles; defective ovulation; pathology yellow body. N is the background of what is happening hormonal changes disrupted the structure of the endometrium, what ultimately prevents implantation of the fertilized ovum and the normal development of pregnancy and impaired function luteum, which secretes insufficient progesterone is the cause of spontaneous miscarriage in early pregnancy [2, 6].

Within pregravidarnoy preparation for miscarriage due to chronic inflammation of the genitals or failure of hormonal function of ovaries inflammatory Genesis traditionally provide medical therapy of chronic endometritis and normalization of hormonal status. Treatment includes: antibacterial, antimycotic, antiviral therapy, systemic enzyme therapy, immunomodulators, restoration of normal biocenosis. Correction NLF maintained by progesterone [1, 5]. The duration of therapy exceeds 3 months, which requires a lot of care of the patient in the use of drugs and increases the share of financial costs. In addition, the known adverse effects of antibiotic, antimycotic treatments and medications progesterone on liver function that requires monitoring of biochemical parameters of blood.

In recent years, in medicine in General and in gynecology in particular prevailed point of view about the need for reasonable limits on medicamentos the second load on the body of the patient and the wider application of preformed physical factors [2]. Mud, or peloid, is one of the most physiological of natural physical factors [3].

The objective of the proposed method of treatment of miscarriage in the early weeks of gestation due to chronic inflammation of the genitals or failure of hormonal function of ovaries inflammatory Genesis is to expand the Arsenal of effective and safe methods of non-pharmacological therapy of this pathology.

The essence of the method is the use as a medicinal product pharmaceutical drug therapeutic Dead sea mud (pelotherapy). In the modern view the main therapeutic effect provide chemical and biological components of peloids. High therapeutic activity of the mud of the Dead sea due to its high salinity. Inorganic chemical components absorbed by the mucous membranes, affect numerous receptors and blood vessels, stimulates the microcirculation. Bactericidal effect due to the presence of peloids substances such as bacteriophages and antibiotics. Makeups therapeutic mud biogenic stimulators activate cellular metabolism and regenerative processes [3]. Hormone-like effect explains the positive effects of medicinal mud on the bodies of reprodu the active system (for example, correction luteal insufficiency) [3, 7].

So, according to the proposed method the use of disposable polymer injectors with gel based on Dead sea mud intrawaginalno 12 treatments daily for 30-60 minutes after 7 days after surgical removal of the ovum by a single course in complex treatment of miscarriage in the early weeks of gestation due to chronic inflammation of the genitals or failure of hormonal function of ovaries inflammatory Genesis, increases the effectiveness of therapy up to 50%. Adverse events during treatment gel is not registered (when using hormonal therapy, the duration of treatment is 3 months, possible unwanted side effects: intermenstrual bleeding, dizziness, headache, abnormal liver function).

The efficacy and safety of the developed method of treatment of miscarriage in the early weeks of gestation due to chronic inflammation of the genitals or failure of hormonal function of ovaries inflammatory Genesis confirmed in a randomized clinical trial. Thus, the use of this method of treatment in the complex treatment of miscarriage in the early weeks of gestation due to chronic inflammatory p is ocess genitals or failure of hormonal function of ovaries inflammatory Genesis helps to restore the two-phase cycle in 72.2% of women in control - 27,8%), the normalization of the structure of the endometrium in 60% (in control - 20%)reduction of signs of chronic endometritis to 13.3% (in control - 46,7%), pregnancy within one year - 92,3% (in the control - 42,9%). The results obtained allowed pathogenetically to justify the application of the developed method for the treatment of complex pregravidarnoy preparation for miscarriage in the early weeks of gestation due to chronic inflammation of the genitals or failure of hormonal function of ovaries inflammatory Genesis.

Contraindications to application of the developed method are: General contraindications to sanatorium-resort treatment, acute inflammatory diseases and suppurative processes; all venereal diseases; hypersensitivity to the components of the product; malignant neoplasms and suspicion on them; pregnancy; menstruation [3].

The developed method intravaginal pelotherapy should be used in combination pregravidarnoy preparation for miscarriage in the early weeks of gestation due to chronic inflammation of the genitals or failure of hormonal function of ovaries inflammatory Genesis, taking into account contraindications.

Example 1.

Patient N., 22 years. Parvovirinae. Installed the automotive technician is C: Incomplete miscarriage at 8 weeks of pregnancy. Bacterial vaginosis. After manual vacuum aspiration residues of the ovum and antibiotic therapy were assigned to a disposable injector with a gel based on Dead sea mud intrawaginalno 12 treatments daily for 30 minutes in one course. 3 months after treatment registered the pregnancy ended urgent delivery.

Example 2.

Patient B., 28 years. Diagnosed with non-developing pregnancy early period. NLF. After surgical removal of the ovum from the 7th day were assigned disposable injectors with gel based on Dead sea mud intrawaginalno 12 treatments daily for 30 minutes in one course. After 3 months showed restoration of two-phase cycle, the normalization of the hormonal status, full secretory transformation of the endometrium. In the next cycle of registered pregnancies ended urgent delivery.

Literature

1. Ilizarov N.A. Habitual miscarriage: pathological analysis of the endometrium, clinical features and rationale for the strategy of therapy: author. dis. ... Dr. med. Sciences: 14.03.02, 14.01.01 / Nailsea. - Novosibirsk, 2009. - 47 S.

2. Myskova YOU Restorative therapy after suffering a non-developing pregnancy / Youmaybe., Digimicro // Rus. the honey. Journe. - 2008. - T.16., No. 29. - S-192.

3. Pelotherapy: real possibilities and prospects of application in gynecology / edited Wierzynski. - M.: Mediabar StatusPraesens, 2011. - 8 S.

4. Early pregnancy / edited Wierzynski, Arr. - M.: StatusPraesens, 2009. - 480 S.

5. Manual of outpatient care in obstetrics and gynaecology / edited by V.I. Kulakov, Vinpalace, Wierzynski. - M.: GEOTAR-Media, 2007. - 1030 S.

6. Sidelnikov V.M. Miscarriage: hands. for doctors / Vmesatelistve, Getsuga. - M., 2010. - 536 S.

7. Artymuk, N.V. Intravaginal gel prepared from Dead Sea peloid for treating luteal-phase defect / N.V.Artymuk, .F.Kira, T.A.Kondratieva // J. ofGynecol. and Obstet. - 2010. - Vol.108. - P.72-73.

The way pregravid preparation for miscarriage in the early weeks of gestation due to chronic inflammation of the genitals or failure of hormonal function of ovaries inflammatory Genesis by intravaginal administration of medicinal means, characterized in that as a drug use disposable injectors with gel based on Dead sea mud 12 treatments daily for 30 minutes one course at the end of the main anti-inflammatory treatment after spontaneous abortion in the early stages.



 

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21 cl, 111 ex, 10 tbl

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20 cl, 5 tbl, 31 ex

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5 cl, 4 tbl, 18 ex

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16 cl, 3 tbl, 6 ex, 2 dwg

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12 cl, 73 ex

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11 cl, 70 tbl, 765 ex

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8 cl, 33 ex

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3 cl

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11 cl, 1 tbl, 13 ex

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3 cl, 1 tbl, 22 ex

FIELD: medicine.

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1 ex

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1 tbl, 1 ex

FIELD: medicine.

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2 ex

FIELD: medicine.

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3 cl, 2 tbl, 10 ex

FIELD: medicine, pharmaceutics.

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14 cl, 8 dwg, 2 tbl, 33 ex

FIELD: chemistry.

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EFFECT: obtaining a novel pharmaceutical salt of 8-methyl-7-[5-methyl-6-(methylamino)-3-pyridinyl]-1-cyclopropyl-4-oxo-1,4-dihydro-3-quinoline carboxylic acid, characterised by good solubility in water, which influences bioavailability of the active ingredient.

7 cl, 16 dwg, 2 tbl, 9 ex

FIELD: medicine.

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3 cl, 1 ex

FIELD: medicine.

SUBSTANCE: method of treating periodontitis provides professional hygienic oral cleansing, antiseptic therapy, local drug-induced therapy. The local drug-induced therapy is two-staged with the use of zeolite-containing fossil flour with particle size of 0.3-0.4 mm. The first stage involves gingival infriction of a mixture consisting of zeolite-containing fossil flour and distilled water taken in equal weight parts for 10-15 min; the second stage includes applications of tampons impregnated with a mixture containing 2.5-3 weight parts of fossil flour and 1-1.5 weight parts of distilled water on the affected gingiva; the length of the local drug-induced therapy is 12-14 days.

EFFECT: effective treatment of periodontitis enables stable reduction of periodontal inflammation, fastening the remission time and reducing the number of aggravations.

2 tbl, 4 ex

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