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IPC classes for russian patent Method for correction of total blood serum baee-esterase activity using soya protein isolate (RU 2509568):
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 / 2245143
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FIELD: medicine.
SUBSTANCE: method refers to preventive medicine and concerns decreasing total BAEE-esterase activity. For this purpose, soya protein isolate 30 gram has been daily introduced into the subjects for 2 months.
EFFECT: decreasing the BAEE-esterase activity of protein-degrading enzymes can be used to prevent inflammatory processes.
1 ex, 1 tbl
The method relates to the field of preventive medicine and can be used as an additional means for correcting baee-esterase activity to reduce the risk of inflammatory processes.
In the development of pathological conditions involving inflammation involves all types of proteolytic enzymes [2]. Proteolytic enzymes serine has baea-esterase activity, which is increased in inflammatory processes in the body.
It is known that inhibitors of soybean reduce the activity of some proteolytic enzymes [4].
It is established that soy products are used as a means of diet and dataprotection of several diseases [1].
Soybean protein can be absorbed into the bloodstream through the gastrointestinal tract [5].
The method of regulation baee-esterase activity of proteolytic enzymes in the body through intake of soy protein isolate.
The technical result of the present invention is the use of soy protein isolate for correction baee-esterase activity of blood serum that can serve as a prevention of inflammatory diseases. The method does not require expensive, special treatment, systematic control.
The method is as follows. Within 2 months of egene is but a group of healthy people ate soy protein isolate, with antiproteolytic activity, in the amount of 30 grams per day. As a result, the level baee-esterase activity of serum significantly decreased by 20%.
Isolate soy protein is myopically powder without taste and does not require special preparation before use. Isolate enough to mix with water or fruit juice.
Example
The study was conducted on 30 healthy men and women aged 35-60 years. The participants received daily 30 g of soy protein isolate. A blood examination was taken from the cubital vein in the morning on an empty stomach before the study and after 2 months of taking soy protein isolate. In serum measured total bee-asterisknow activity of proteolytic enzymes [3].
Table 1 presents the results of reception of soy protein isolate for 2 months, reflecting a significant decrease baee-esterase activity of blood serum 20% (p<0,05): before receiving this activity was 0,343±0,010, and after receiving 0,282±0,008.
| Table 1 |
|
Indicators |
| Time studies |
Baee-esterna activity of blood serum (against the sustained fashion units) |
| Before taking |
0,343±0,010 |
| After taking |
0,282±0,008 |
Thus, the increase baee-esterase activity of blood serum via reception isolate soy protein appears to be reliable and can be used to correct the overall level baee-esterase activity in the body in inflammatory processes.
Literature
1. Borodin E.A., T. Aksenova, Anishchenko NI Food products from soybeans. A new role // Vestnik DVO ran. 2000. No. 5. P.72-85.
2. Drakan E.A., Baluevsky and THUS al. Study the expression of cathepsins D and L in the process of oncogenic transformation of fibroblasts. Questions of medical chemistry, 1994. No. 3. T. C.2-6.
3. Ogloblin OG, Maliyev BM Activity of proteases of granulocytes and their kislotostabilen inhibitors in bronchial secretions of patients with newly diagnosed pulmonary tuberculosis, complicated by nonspecific bronchitis // Problems of tuberculosis. 1983. No. 2. Pp.33-37.
4. J.N. Losso The biochemical and functional food properties of the bowman-birk inhibitor. Crit Rev Food Sci Nutr. 2008 Jan; 48(1):94-118.
5. Kennedy A.R. Chemopreventive agents: protease inhibitors // Pharmacol. Ther. 1998. V.78, Issue.3. P.167-209.
The way to reduce bee-esterase activity of the blood serum, which consists in the fact that healthy people over 2 months of daily use 30 grams of soy protein isolate.
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