Method of determining individual risk of acute pancreatitis development after endoscopic transpapillary intervention. RU patent 2506037.
| Method for determining microorganism sensitivity to antimicrobial substances / 2505813 Determining the microorganisms sensitivity to antimicrobial substances is ensured by sampling a biological material, incubating the microorganisms found in the biological material on a nutrient medium, introducing the analysed antimicrobial substance into the nutrient medium, and analyzing the prospected result. The microorganisms are cultured using a dense rich nutrient medium. The analysed antimicrobial substance is introduced into the nutrient medium before culturing the microorganisms in the concentration close to the maximum attainable one in the biological material sampling point has started. The microorganism sensitivity to the antimicrobial substances are assessed after the evident microorganism growth is observed in the control inoculation. The nutrient medium can contain vitamins, and/or amino acids, and/or food additives. |
| Method for determining nuclear lens density / 2505812 Patient's venous blood serum is analysed for vascular endothelial growth factor (VEGF). If the derived values in the patients suffering type 1 diabetes mellitus is 141-187 pg/ml, degree 1 and very low nuclear lens density are diagnosed; the value of 188-234 pg/ml enables diagnosing degree 2 and low nuclear lens density; and the value of 235-280 pg/ml shows degree 3 and moderate nuclear lens density. In the patients suffering type 2 diabetes mellitus, the VEGF value of 281-330 pg/ml provides diagnosing degree 2 and low nuclear lens density; the derived value of 331-382 pg/ml shows degree 3 and moderate nuclear lens density; if the value is 383-432 pg/ml, degree 4 and high nuclear lens density are diagnosed; the respective value of 433-478 pg/ml provides diagnosing degree 5 and very high nuclear lens density. In the patients diagnosed with no diabetes mellitus, the VEGF value of 290-336 pg/ml ensures diagnosing degree 2 and low nuclear lens density; the value of 337-379 pg/ml provides degree 3 and moderate nuclear lens density; if the value is 380-426 pg/ml, degree 4 and high nuclear lens density are diagnosed; the derived value of 427-465 pg/ml provides diagnosing degree 5 and very high nuclear lens density. |
 Method for cellular analysis of probe by means of virtual analytical plate / 2504777Probe (2) is processed for cellular analysis. The above processing is intended for marking of pathologic cells among sound cells of a probe. Then, several pictures of probe (6) located on analytical plate (6) are taken to obtain a variety of pictures, each of which displays one zone of analytical plate (6). The above pictures located in a row form composite picture (20) of the sample. Besides, an automatic scrolling of all the taken pictures of sample (2) is performed on a display device at the pre-set scrolling speed. The above provided speed is such that an investigator can analyse a picture and determine whether the displayed sample zone contains potentially pathological cells or not; scrolling stops automatically at detection of an anomaly that can bear evidence of availability of a pathological cell. |
 Diagnostic technique for ischemic nephropathy in newborns / 2504776Diagnosing of ischemic nephropathy in the newborns is ensured by diagnostic testing for 1-3 days of life according to anamnestic and biochemical findings, involving the determination of foetal age, sodium ion concentration, urine microalbumin, urine carbonic anhydrase to creatinine relation and blood free bilirubin concentration; that is followed by the calculation of a probability (P) of ischemic nephropathy by formula. If the value P is more than 50%, ischemic nephropathy is diagnosed in the newborns. |
 Method for assessing inducing action of cytomegalovirus infection on hemoglobin oxygenation in third trimester of gestation with underlying hemoglobin and 2,3-bisphosphoglycerate measurement in peripheral red blood cells / 2504775To assess a threatening hypoxia formation in the third trimester of gestation, peripheral blood is analysed for a cytomegalovirus antibody titre, peripheral blood 2,3-diphosphoglycerate, haemoglobun by cytophotometry, and peripheral blood oxyhaemoglobin. If observing an increase of the cytomegalovirus antibody titre to 1:1600, 2,3-diphosphoglycerate to 7.2 mcmole/ml, a decrease of hemoglobin to 72.25 standard units, a decrease of oxyhaemoglobin to 96.0%, the threatening hypoxia is expected. |
| Method for prediction of infectious inflammation of postoperative wound in external fixation of long bones / 2504774 Blood count is analysed, and a Calph-Caliph leucocytic intoxication index is calculated on the 3rd post-fracture day. If the derived value is 1.8 and more, the following external fixation is expected to be accompanied by the development of an infectious inflammation of the wound. |
| Method of predicting unfavourable course of locally spread forms of human papilloma virus-associated cervical cancer / 2504326 Invention relates to field of medicine, namely to oncogynecology. Immunological parameters are determined: absolute number of lymphocytes (lim_ab), TNFα (TNFα-k) and IL-10 (IL-IL10_k) in peripheral blood, as well as TNFα (TNFα-c) and IL-4 (IL-4_c) in cervical mucus. On the basis of obtained data parameter F(x) is calculated by formula: F(x): P(x)=9.265+1,749x(lim_ab)+0.013×(IL-4_c)+0.005×(IL-10_k)-0.410×(TNFα-k)-0.206×(TNPα-c). If value F(x) is higher than 0.555, unfavourable course of tumour process is predicted, in case if it is lower than 0.555, favourable course is predicted. |
 Method for assessing conditions of proliferative cervical diseases / 2503960Method is staged: 1) cervical canal scrapes and biopsy materials of the uterine cervix are used to recover DNA of human papilloma virus; 2) virus genotype is determined; 3) patients with HPV 16 positive CIN are sampled; 4) real-time PCR is used to determine the number of virus DNA copies and a degree of its integration with a host gene (a physical status); 5) a threshold level of the viral load is stated taking into account the physical status of the virus (6.5 lg HPV DNA copies 16 per one cell); 6) the patients are classified according to the determined threshold viral load and physical status of the virus (the episomal and integrated form); 7) the poorly predicted patients having the high viral load (≥6.5 lg DNA copies per one cell) are detected in the episomal form of the virus, while the low load (<6.5 lg DNA copies per one cell) is shown by the integrated form of the virus. |
| Method for prediction of individual risk of bronchial asthma in regions with high and low incidence of helminth infections / 2503959 Presence or absence of opisthorchiasis is stated; and polymorphous versions of genes and a possibility of referring an individual to a group with a low or high risk of bronchial asthma are found. If observing one of any risk combinations in accordance with the SOCS5-IFNG-opisthorchiasis model in the patient, the high risk of bronchial asthma is diagnosed. If observing one of any protective combinations in accordance with the IL4-TBX21-SOCS5 model in the patient, the low risk of bronchial asthma is diagnosed. |
 Method of individual quantitative assessment of ischemic heart disease development / 2503405Invention relates to cardiology, pathophysiology, biochemistry and pharmacology. To assess development of ischemic heart disease value of discriminant function is calculated by a set of parameters: age, height, weight, Quetelet index, Broca's index, abdominal obesity, triglycerides, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, atherogenicity index, arterial pressure, glucose, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, α-amilase, total protein, albumin, uric acid, urea, creatinine, creatine kinase, alkaline phosphatase, total bilirubin, direct bilirubin, ADP-induced platelet aggregation, collagen-induced platelet aggregation, platelet number, mean platelet volume, number of red blood cells, hematocrit, hemoglobin, mean corpuscular volume, RDW-CV, average content of hemoglobin in blood, number of white blood cells, percent content of neutrophil granulocytes, percent content of eosinophils, percent content of basophils, percent content of lymphocytes, percent content of monocytes, mean content of hemoglobin on red blood cell. Conclusion about initial stage of IHD development, 50% risk of disease or 100% development of IHD is made on the basis of obtained value. |
 Simultaneous model-based segmentation of objects satisfying predefined spatial relationships / 2505860Surface mesh is adapted to each object to be segmented. To avoid or reduce the possibility of mesh collision, a plurality of connecting edges for connecting two neighbouring meshes are used. Connection energy defined for the plurality of connecting edges allows controlling the spatial relationship between the first and second mesh. This is achieved by including in the connection energy expression terms that will increase the connection energy when the length of edges of the plurality of connecting edges connecting the first and second mesh decrease. Using the reference configuration of the plurality of connecting edges defined based on the pre-positioned first and second mesh allows taking into account prior knowledge about a typical spatial relationship between the first and second object of the plurality of objects. |
| Method for prediction of risk of development of arterial hypertension in tubalars, ethnic group native to altai republic / 2505814 Method provides considering the age, education, smoking, obesity (OB), hypercholesteremia (HCS), salt abuse, Quetelet body weight index: normal (NBW), overweight (OWT), waist circumference (WC), waist-to-hip ratio (WHR), low-density lipoprotein cholesterol (LDL cholesterol) and atherogenicity index (AI), hypertriglyceridemia (HTG), hyperuricemia, social factors: marital status, income and genetic markers: blood group, Rh rhesus and MN. A prognostic coefficient (PC) is scored for each factor. If the PC value is (+6) points and more, a predisposition to the development of arterial hypertension in Tubalars, an ethnic group native to the Altai region is predicted. |
 Method for detoxification in patients suffering obstructive jaundice of various origins / 2505321Ultrasound-assisted percutaneous transhepatic biliary drainage is followed by an infusion therapy that is derived from patient's body weight, sodium, glucose, urea with underlying hepatic passage and blood bilirubin recovery. The infusion therapy volume is derived by formula: INFUSION THERAPY VOLUME=(PLASMA OSMOLARITY+BLOOD BILIRUBIN)/15000×BODY WEIGHT, wherein: plasma osmolarity (mmole/l)=Na (mmole/l) * 1.86 + glucose (mmole/l) + urea (mmole/l) +10, mosm/l; bilirubin, mcmole/l; m - body weight, kg; 15000 is an experimental number. |
 Method for specifying individual running load for exercise tolerance development / 2505264Individual is challenged to perform a dead load test at 75% adequate maximum oxygen consumption and presented with a sequence of paired light pulses separated by an initial inter-pulse period and repeated after a regular interval of time. A threshold inter-pulse period is determined occasionally, wherein two pulses in a pair are fused in one; at the same time, heart rate is measured. The derived threshold inter-pulse periods and heart rates are used to plot flow charts of 'threshold inter-pulse period - test time' and 'heart rate - test time'. The testing procedure is performed until the threshold inter-pulse plateau period is produced on the chart. The testing procedure is repeated after the load rest increased by 50 Wt until the threshold inter-pulse period chart has a descending trend. A running load of heart rate is specified according to the previous threshold inter-pulse plateau period chart. |
| Method of predicting unfavourable course of locally spread forms of human papilloma virus-associated cervical cancer / 2504326 Invention relates to field of medicine, namely to oncogynecology. Immunological parameters are determined: absolute number of lymphocytes (lim_ab), TNFα (TNFα-k) and IL-10 (IL-IL10_k) in peripheral blood, as well as TNFα (TNFα-c) and IL-4 (IL-4_c) in cervical mucus. On the basis of obtained data parameter F(x) is calculated by formula: F(x): P(x)=9.265+1,749x(lim_ab)+0.013×(IL-4_c)+0.005×(IL-10_k)-0.410×(TNFα-k)-0.206×(TNPα-c). If value F(x) is higher than 0.555, unfavourable course of tumour process is predicted, in case if it is lower than 0.555, favourable course is predicted. |
| Method of early diagnostics of cognitive disorders in patients of young and mature age with metabolic syndrome / 2504325 Invention relates to medicine, namely to neurology, geriatrics and psychiatry, and can be used for diagnostics of cognitive disorders with metabolic syndrome at early stage of diseases in patients of young and mature age with metabolic syndrome. Early diagnostics of cognitive changes is carried out by means of neuropsychological testing in complex with method of cognitive induced potential, carried out after analysis of all testing results and determining quantitative assessment of cognitive functions. |
| Method of medical-psychological adaptation of railway employees / 2503402 Invention relates to medicine, namely to preventive, rehabilitation, railway medicine, general medical (family) practice, neurology and psychotherapy, and can be used for prevention of stress and pre-stress states, as well as consequences of uncompensated stress response of railway transport employee's organism irrespective of character peculiarities of stressor or stressors. Employee's anthropometric parameters are measured: height, weight, chest circumference, index of cardiovascular system activity - pulse. Individual digital series (IDS) of RW transport employee is calculated on the basis of obtained data. Employee gets acquainted with method of IDS calculation and session of psychotherapy, during which employee in convenient position, relaxed state sits in front of computer screen and whispers IDS, is started, with IDS periodically displayed on screen, to finish the session employee makes quiet deep inhalation and exhalation. |
 Method of cardiac signal processing / 2503401Invention relates to medical equipment, in particular to cardiac equipment. Isoelectric line drift in electrocardiosignal (ECS) recording is eliminated. Approximation of observed electrocardiosignal realisation is determined. Electrocardiosignal is divided into RR-intervals and synchronisation of RR-intervals by R-wave maximum is performed. RR-intervals with equal duration are identified. RR-intervals with equal energy are identified from RR-intervals with equal duration and coherent addition of those identified RR-intervals with equal energy, for each of which coefficient of mutual correlation of approximation of fragment of electrocardosignal, corresponding to said RR-interval and support signal is larger than preliminarily specified value, is performed. |
| Method of clinical assessment of inflammation activity in case of chronic calculous cholecystitis / 2503400 Invention relates to field of medicine, namely to gastroenterology and can be used for assessment of clinical inflammation activity in case of chronic calculous cholecystitis at prehospital stage of patients monitoring. Questioning and objective examination of patients is carried out. Parameters, reflecting degree of activity of local and general inflammatory process and severity of disease aggravation are identified and analysed, the following parameters being related to them: manifestation of pain syndrome symptoms, biliary dyspepsia symptoms, symptoms of general inflammatory response syndrome, with each clinical sign being assessed in points. To localise pain gradations and diagnostic coefficients are identified. Specific weight of each diagnostic coefficient is calculated and its value is used to determine minimal, average or expressed degree of inflammation. |
| Method of diagnosing recurrences and metastases of malignant neoplasms after radical treatment / 2502469 Invention relates to field of medicine, namely to oncology. Catheterisation of patient's venous system is carried out. Fibre-optic spectrometer sensor is moved via veins to corresponding organs to the level of segmental veins and absorption coefficient of sample β is determined in real time mode. β value higher or equal 900 cm-1 testifies to presence of malignant neoplasm or metastases in organ or its segment. |
| Method for diagnosing the cases of superior thorax aperture syndrome / 2243717 Method involves carrying out ultrasonic scanning examination of subclavian artery over its whole extent in physiological arm position with arterial blood pressure being measured in the middle one third of the arm. Next, when applying compression tests, blood circulation parameters variations are recorded in distal segment of the subclavian artery with arterial blood pressure being concurrently measured. Three degrees of superior thorax aperture syndrome severity are diagnosed depending on reduction of linear blood circulation velocity and arterial blood pressure compared to their initial values. Mild one takes place when linear blood circulation velocity reduction reaches 40% and arterial blood pressure 20% of initial level, moderate one when linear blood circulation velocity reduction reaches 70% and arterial blood pressure 50% and heavy one when linear blood circulation velocity reduction is greater than 70% of initial level and arterial blood pressure is greater than 50% to the extent of no blood circulation manifestation being observed in the subclavian artery. |
FIELD: medicine.
SUBSTANCE: invention relates to field of medicine, in particular to endosurgery. To determine individual risk of acute pancreatitis development after endoscopic transpapillary intervention, analysis of demographic data and biochemical blood test is carried out. In the course of pre-operation examination index of risk of acute pancreatitis development (IRPD) is determined by formula: IRPD=(A1×2/An+Bt/100)×(40/C1)×D×E, where: A1 stands for values of patient's blood amylase; An stands for normal maximal values of blood amylase; ; B1 stands for value of patient's blood bilirubin; C1 stands for patient's age; D stands for patient's sex: D=2, if patient is female and D=1, if patient is male; E stands for character of the main disease: E=1 in patients with tumours of hepatopancreatobiliary zone; E=2 for patients with choledocholithiasis, E=3 in patients with virsungolithiasis, with stenosis of major duodenal papilla, as well as in patients with combination of choledocholithiasis and stenosis of major duodenal papilla. If IRPD <0.5, risk of acute pancreatitis development is lower than 2%; if IRPD =0.5-0.99 risk of development constitutes 2-10%; if IRPD=1-1.99, risk of development is 11-20%; if IRPD=2-3.99 - 21-30%; if IRPD=4-5 - 31-40%; if IRPD>5 - more than 40%.
EFFECT: method makes it possible to increase accuracy of determining individual risk of acute pancreatitis development after endoscopic transpapillary intervention due to determination of IRPD, based on multi-factor analysis of informative criteria of particular patient.
2 ex
Invention refers to medicine, in particular to endosurgery and relates to a method of determination of individual risk of acute pancreatitis after endoscopic interventions in a particular patient.
Endoscopic intervention (), which include endoscopic , balloon major duodenal papilla, drainage, endoprosthetics of the common bile and pancreatic ducts, retrograde cholangiopancreatography most often in the early postoperative period is complicated by acute pancreatitis.
The overall frequency of pancreatitis after performing endoscopic interventions, according to various authors, is within 8,7%-42,3% [1, 3], of pancreonecrosis diagnosed in 10% of cases [4]. Mortality in the development of these complications reaches 25%-80% [1].
There is a method of determining the risk of acute pancreatitis after endoscopic intervention, based on the belief that acute pancreatitis can be a complication of any of any patient. In this regard, all of the patients in this category are preventive measures to the maximum extent.
The disadvantage of this method is that the prevention of the specified complications, often unnecessarily, spent considerable material resources, and time.
Known second way to determine the degree of risk of acute pancreatitis, including subjective analysis of demographic data, the nature of the underlying disease, adverse factors that increase the risk: young age, female gender, a history of episodes of acute pancreatitis, the absence of chronic pancreatitis, the lack of experience of the doctor-endoscopist etc. (prototype).
The disadvantage of this method is that the definition of the degree of risk is based only on subjective signs and with its help it is possible to determine only the trend in the group, not the degree of risk of acute pancreatitis in a particular patient.
The technical result of the claimed method is to increase the accuracy of determination of individual risk of acute pancreatitis after endoscopic interventions.
The technical result is achieved by the method of determining the individual risk of acute pancreatitis after endoscopic interventions, including the analysis of demographic data and the results of biochemical studies of blood particular patient, in the course of preoperative examination determine the risk indicator of acute pancreatitis () by the formula:
=(A 1 x 2/A n +B 1 /100)x(40/C 1 )x D x E where: 1 - amylase values patient's blood; And n is the maximum values of amylase blood tests are normal; B 1 - the value of bilirubin patient's blood; 1 - the age of the patient; (D - floor patient: D=2, if the patient is a woman and D=1, if the patient is male; F - the nature of the underlying disease: E=1 - patients with tumors hepatopancreatobiliary zone F=2 patients with choledocholithiasis, E=3 - patients with , with stenosis of the major duodenal papilla, as well as patients with a combination of choledocholithiasis and stenosis of the major duodenal papilla;
and when <0,5 risk of acute pancreatitis less than 2%; =0,5-0,99 - 2-10%; =1-1,99 - 11-20%; =2-3,99 - 21-30%, =4-5 - 31-40%; >5 - more than 40%.
The essence of the proposed method
Increase the accuracy of determination of individual risk of acute pancreatitis after endoscopic interventions is achieved by determining the objective of the integral diagnostic indicator - indicator of the risk of acute pancreatitis (), based on multivariate analysis of the informative criteria for the individual patient: age, sex, nature of the underlying disease, biochemical indices of blood. All informative criteria are quantitative value. Increasing the accuracy of determining the degree of risk is based on the evaluation of individual objective quantitative characteristics of the specific patient, in particular, the concentration in the blood bilirubin and amylase.
Conducted a retrospective study 608 case histories of patients, which in 2007-2012 in Clinic №1 held endoscopic intervention about the syndrome of biliary hypertension.
All patients were divided into subgroups, subgroups differ gender, age, nature of the underlying pathology, baseline levels of bilirubin, amylase and blood. Were the average indicators of the incidence of acute pancreatitis (the ratio of the number of cases of acute pancreatitis to the total number of patients in this subgroup, expressed as a percentage) of men and women, as well as the indicators in each of the subgroups. As a result of mathematical processing of the received data the regularities, represented by the above formula.
Methodology of the proposed method.
The method is as follows. After common clinical examination and laboratory studies of the blood of a patient taking into account data:
A 1 - amylase values patient's blood; And n is the maximum values of blood amylase is normal.
B 1 - the value of bilirubin patient's blood;
C 1 - the age of the patient;
D - floor patient: D=2, if the patient is a woman and D=1, if the patient is a man;
E - nature of the underlying disease: E=1 - patients with tumors hepatopancreatobiliary zone F=2 patients with choledocholithiasis, E=3 - patients with , with stenosis of the major duodenal papilla, as well as patients with a combination of choledocholithiasis and stenosis of the major duodenal papilla;
according to the formula: =(A 1 x 2/A n +B 1 /100)x(40/C 1 )x D x E
define indicator of the risk of acute pancreatitis (). When <0,5 risk of acute pancreatitis less than 2%; =0,5-0,99 - 2-10%; =1-1,99 - 11-20%; =2-3,99 - 21-30%, =4-5 - 31 -40%; >5 - more than 40%.
Examples of specific performance.
Example 1.
The patient,, 63 years old, case history №4751, was admitted to the surgical Department of the hospital №1 20.10.11, with a diagnosis of Acute calculous cholecystitis. Choledocholithiasis. Mechanical jaundice.
Decision on two-stage surgical treatment. At the first stage it was decided to perform endoscopic intervention.
When studying the history of the diseases are defined gender (woman, (D=2)), age (63 years, (1 )), the nature of the underlying pathology (choledocholithiasis, (E=2)), biochemical indices of the patient blood (blood bilirubin patient - 247 mmol/l (B-1 ); the maximum value amylase normal blood - 220 U/l (n ), amylase blood of an ill - 96 U/l (1 )).
=(1 x 2/n +B 1 /100)x(40/C 1 )x D x E=(96 x 2/220+247/100)x(40/63)x 2 x 2=8,49
Considering the result (>5), and determined that the risk of acute pancreatitis exceeds 40%. With the purpose of prophylaxis of acute pancreatitis as anesthesia it was decided to use epidural analgesia and at the final stage of endoscopic intervention perform stenting of the main pancreatic duct, as a highly effective methods of prophylaxis of acute pancreatitis.
20.10.11, under epidural analgeziei was performed urgent endoscopic , lithoextraction, stenting of the main pancreatic duct.
Diagnosis: Acute calculous cholecystitis. Choledocholithiasis. Mechanical jaundice. Cholangitis.
Early postoperative complications was not. In the postoperative period was the conservative therapy is prolonged epidural analgesia. After 6 hours of manipulation the patient was transferred from intensive care to a surgery Department. Within 2 days normalization of laboratory indicators, disappeared clinical signs cholangitis. 23.10.11, the second stage treatment - laparoscopic cholecystectomy. The patient was discharged on 8-th day in satisfactory condition.
Example 2.
Patient C., 77 years old, case history №2426, was admitted to the surgical Department of the hospital №1 17.06.12, with a diagnosis of Tumor of the head of the pancreas. Mechanical jaundice.
18.06.12 year the decision on endoscopic correction of the biliary hypertension.
When studying the history of the diseases are defined gender (male, (D=1)), age (77 years, (1 )), the nature of the underlying pathology (tumor hepatopancreatobiliary zone, (E=1)), biochemical indices of the patient's blood (blood bilirubin patient 44 mmol/l (1 ); the maximum value amylase normal blood - 220 U/l (n ), amylase blood of the patient 48 U/l (1 )).
=(1 x 2/n +B 1 /100)x(40/C 1 )x D x E=(48 x 2/220+44/100)x(40/77)x 1 x 1=0,46
Considering the result identified low (less than 2%) the risk of developing acute postoperative pancreatitis.
Activities for the prevention of acute pancreatitis were not conducted.
18.06.12 were made endoscopic , endoprosthetics of the common bile duct.
The postoperative course was uneventful, was symptomatic therapy.
The patient was discharged after 3 days after endoscopic intervention in a relatively satisfactory situation.
The advantages of the positive effect of the declared method:
- Allows to substantiate the necessity of implementation of measures aimed at preventing the development of acute pancreatitis after a particular patient;
- Reduce the frequency of occurrence of acute pancreatitis due to the exclusion of cases of unfounded denial of measures on the prevention of acute pancreatitis;
- Reduce material costs therapy due to optimization of the application of measures of a preventive character;
- Application of the claimed process helps the physician in selecting the volume of endoscopic intervention.
Sources of information
1. Malyarchuk V.I. Fedorov, A.G., Davydov S.V. and other Factors affecting results of endoscopic interventions in patients with choledocholithiasis and stenosis of the major duodenal papilla. // Endoscopic - surgery-2005. Volume 11, number 2. - P.30-39.
2. Revyakin V.I., Klimov P.V., Ibragimov n I and other Complications and lethality after endoscopic : experience 1300 operations. Russian Symposium « endoscopic surgery»: abstracts edited by Professor I. . M: 1998; 67-69.
3. Rabenstein So, Schneider N.T., Hahn E.G. et al. 25 Years of Endoscopic Sphincterotomy in Erlangen: Assessment of the Experience in 3498 Patients. // Endoscopy. - 1998; 30; 9. - P. 195-201.
4. P. Salminen, Laine S., Gullichsen R. Severe and fatal complications after ERCP: Analysis of 2555 procedures in a single experienced center. // Finland: Surg Endosc. - 2008; 22. - P. 1965-1970.
Method of determination of individual risk of acute pancreatitis after endoscopic interventions, including the analysis of demographic data and the results of biochemical studies of blood particular patient, characterized in that in the course of preoperative examination determine the risk indicator of acute pancreatitis () by the formula: =(A 1 x 2/A n +B 1 /100)x(40/C 1 )x D x E where: A 1 - amylase values patient's blood; And n is the maximum values of amylase blood tests are normal; B 1 - the value of bilirubin patient's blood; 1 - the age of the patient; D sex of the patient: D=2, if the patient is a woman and D=1, if the patient is male; F - the nature of the underlying disease: E=1 - patients with tumors hepatopancreatobiliary zone F=2 patients with choledocholithiasis, E=3 - patients with , with stenosis of the major duodenal papilla, as well as patients with a combination of choledocholithiasis and stenosis of the major duodenal papilla; and when <0,5 risk of acute pancreatitis less than 2%; =0,5-0,99 - 2-10%; when =1-1,99 - 11-20%; =2-3,99 - 21-30%, =4-5 - 31-40%; >5 - more than 40%.