Chitosan carboxyalkylamide hydrogel, preparing it and using in cosmetology and dermatology |
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IPC classes for russian patent Chitosan carboxyalkylamide hydrogel, preparing it and using in cosmetology and dermatology (RU 2476201):
     
 Biocompatible, biodegradable porous composite material and method of producing said material / 2471824
Biocompatible, biodegradable porous composite material contains chitosan and hydrosilicate filler in amount of 0.05-10% of the weight of chitosan and has a system of through pores with size of 5-1000 mcm. The method of producing the material involves mixing hydrosilicate filler, which is pre-dispersed in an aqueous medium with pH=5-7 in an ultrasonic field with frequency v=20-100 kHz for 5-60 minutes, with chitosan in an amount which corresponds to its concentration in the solution of 1-4 wt %, the amount of the filler being equal to 0.05-10% of the weight of chitosan; the obtained mixture is then intensely mixed at temperature of 20-50°C for 20-60 minutes; concentrated acetic acid is added in an amount which enables to obtain, in the mixture of the aqueous solution, acetic acid with concentration of 1-3%; the mixture is intensely mixed at temperature of 20-50°C for 20-250 minutes and then cooled to temperature of -5 to -196°C; the solvent is removed in a vacuum; the obtained end material is treated with a neutralising agent, washed with water to pH=5-7 and then dried.
 Pectin- and chitosan-based biodegradable film / 2458077
Biodegradable film contains pectin, chitosan, water, 1N hydrochloric acid, a plasticiser - glycerine and a structure-forming agent - 3% methyl cellulose solution.
Solid-phase method of producing bioactive nanocomposite / 2416389
Invention relates to synthetic polymer chemistry. The nanocomposite contains a matrix in form of a cross-linked salt of hyaluronic acid which is modified with sulphur-containing compounds and nanoparticles of a noble metal as filler. A film of the cross-linked salt of hyaluronic acid which is modified with sulphur-containing compounds is obtained through chemical reaction of the salt of hyaluronic acid with a mixture of two sulphur-containing compounds and with a cross-linking agent, under conditions with pressure between 50 and 300 MPa and shear deformation in a mechanical reactor at temperature between 20 and 30°C. The reactor used to obtain the film is a Bridgman anvil.
 Method for producing viable breast cells / 2409664
Solution of viable breast cells after enzymatic degradation in a collagenase solution of analysed tissue at temperature 37°C for 30-35 minutes, are applied on a biomaterial of a native form of hyaluronic acid, stored at room temperature and constant humidity 30-50 %, and cell viability is controlled by discoloration of cell monolayer.
 Novel cross-linking reagents for producing chitosan-based biocompatible materials / 2408618
Articles based on biologically active polymer materials can be used in surgery when treating wounds and as materials for temporary replacement of body tissue, in biotechnology for obtaining matrices for growing cell cultures, in pharmaceuticals as carriers of enzymes and other biologically active compounds. The cross-linking reagents are 2,4-derivatives of 3-oxa glutaric dialdehyde (2,2'-oxydiacetaldehyde). These compounds can be obtained via periodate oxidation of monosaccharides, nucleosides and nucleotides.
 Method of obtaining polysaccharide material / 2392972
Invention relates to a method of obtaining polysaccharide fibre for making materials, specifically for making surgical suture materials absorbable in a human and a mammal body, absorbable and non-absorbable dressing material and absorbable textile matrix materials. The method is characterised by that 2.4-4.0 wt % solution of polysaccharide in dimethylacetamide which contains 4.56-10.00 wt % lithium chloride is mixed with 1.0-5.0 wt % poly-N-vinylpyrrolidone with molecular weight of 8-35 kDa or a metallopolymer complex - fine-grained silver stabilised by poly-N-vinylpyrrolidone in such an amount that, content of fine-grained silver relative polysaccharide dissolved in spinning solution ranges from 0.07 to 0.87 wt %. Mass ratio of polysaccharide: metallopolymer complex equals 88.0-99.0:1.0-12 wt %. The mixture is intensely stirred, held, filtered, degassed and the obtained spinning solution is extruded at room temperature into an alcohol deposition tank in form of water-soluble aliphatic C2 and C3 alcohols. The fibre is then processed in plastification and washing tanks and dried.
 Taxanes covalently bonded with hyaluronic acid or hyaluronic acid derivatives / 2384593
Invention relates to taxane, especially to paclitaxel and docetaxel covalently bonded with hyaluronic acid or a hyaluronic acid derivative, used as active substance in pharmaceutical compositions which are used in oncology, for treating tumours, autoimmune diseases and restenosis, as well as a coating for stents and medical devices. The covalent bond is formed between hydroxyl groups of taxane and carboxyl groups or hydroxyl groups of hyaluronic acid or hyaluronic acid derivatives, or amino groups of deacetylated hyaluronic acid. Bonding can take place using a linking compound (spacer compound) which bonds taxane with hyaluronic acid or hyaluronic acid derivative under the condition that, the linking compound is different from hydrazide.
Composition - osteoinducer and osteoconductor in treatment of bone pathology in dentistry and oral surgery and method of obtaining composition - osteoinducer and osteoconductor in treatment of bone pathology in dentistry and oral surgery / 2383564
Composition includes chitosan gel, which has bactericidal properties, representing matrix for including in it of water solution for "Adgelon" injection, which contains serum glycoprotein from blood of livestock, possessing biological activity in supersmall doses 10-9-10-15 mg/ml, and calcium salt - preparation "Adgelon". In obtaining composition medicine "Adgelon" is immobilised on chitosan gel.
 Complex matrix for medico-biological application / 2360928
Complex matrix consists of at least one biologically compatible polymer of natural origin, structured with sewing agent, which represents two- or multi-functional molecule, selected from epoxides, epihalohydrines and divinyl sulphone, on said polymer inoculated are chains with molecular weight less than 50000 daltons, selected from polymers of natural origin of small size, preferably, derivatives of cellulose or other biological polymer derivatives which naturally are not present in human organism, and/or non-polymerised chains with properties of oxidation inhibitors or ability to inhibit reactions of matrix decomposition, preferably, vitamins, enzymes or molecules, consisting of one or several cycles, degree of inoculation, expressed as ratio of moles of inoculated molecules and quantity of moles of polymer units, constitutes from 10 to 40%. Also described are method of obtaining such matrix and its application for separation, replacement, filling or addition of biological fluid or tissues.
Method for production of modified paper / 2355842
Invention relates to papermaking technology, precisely to production of modified paper with higher gas-proof and heat-protective properties, and can be applied in constructions, aircraft and automobile constructions, shipbuilding. The method includes treatment of paper with the mixture of 5-7% aqueous solution of polyvinyl alcohol with 5-7% aqueous solution of chitosan at their ratio 1:1 within 10-15 minutes, thereafter treatment with 15-20% aqueous solution of methyl phosphate borate and drying.
 Method of improving conductivity of conducting polymer product / 2462485
Disclosed is a method of producing a conducting polymer product in form of fine particles with average size of 0.02-0.05 mcm, with improved conductivity, involving: putting a conducting polymer product, which is a product obtained via polymerisation of 3,4-ethylene dioxythiophene in aqueous solution of polystyrene sulphonic acid and/or polyaniline, water, an organic solvent which is compatible with the conducting polymer product, and carbon dioxide gas into a container operating under pressure; and exposing the medium inside the container operating under pressure to heat and pressure in order to convert carbon dioxide to a supercritical state.
 Method of dissolving aramid polymer in sulphuric acid using kneader with two guides / 2461585
Method involves the following steps: a) feeding a polymer and a solvent into the kneader with two guides; b) mixing the polymer and solvent in order to dissolve the polymer in the solvent to obtain a solution; c) degassing the solution to obtain a spinning solution; d) moving the spinning solution from the kneader using a separate outlet means.
 Method of producing perfluorinated sulpho-cationite membranes through coating from solution / 2427593
Invention can be used in making membrane-electrode blocks used in different types of fuel cells, as well as in portable electronic devices etc. The membranes are obtained through coating from a 5-40% solution prepared from perfluorinated ion-exchange copolymer of tetrafluoroethylene with perfluorosulpho-containing vinyl ester and a tertiary modifying comonomer selected from a group comprising perfluoro-2-methylene-4-methyl-1,3-dioxalane and perfluoroalkylvinyl ester whose alkyl contains 1 or 3 carbon atoms, having equivalent weight of 700-900, number-average molecular weight of 1.0-4.0×105, density 1.79-1.83 kg/m3, degree of crystallinity equal to 1.0-4.5%, and one or more modifying perfluorinated ion-exchange copolymers whose structure is similar to the basic perfluorinated ion-exchange copolymer with equivalent weight of 950-1600, having number-average molecular weight of 4.5-9.0×105, density 1.84-1.91 kg/m3, degree of crystallinity 4.5-12.5%, structural formula:
 Gas-tight modified perfluorosulpho-cationite membrane and method of producing said membrane / 2426750
Invention relates to the technology of producing gas-permeable membranes which can be used in fuel cells at high operating temperature (100°C and higher, methanol fuel cells, low- and high-pressure water electrolysis cells etc). The membrane is made from a copolymer of tetrafluoroethylene with perfluorosulpho-containing vinyl ether and a tertiary modifying perfluorinated comonomer - perfluoro-2-methylene-4-methyl-1,3-dioxalane or perfluoroalkylvinyl ether containing 1 or 3 carbon atoms in the alkyl, and a polymeric or inorganic modifier. The method of making the membrane involves contacting a perfluorosulpho-cationite membrane with a liquid composition containing an ion-exchange perfluorosulpho-polymer, a polymeric or inorganic modifier and a solvent. The perfluorosulpho-polymer with functional sulpho-groups SO3M, where M is a hydrogen, ammonium or alkali metal ion, has equivalent mass of 800-900, and is similar on structure to the membrane polymer. Contacting is carried out at 18-80°C. Particles of the modifier are formed on the surface or inside the membrane at 18-120°C.
 Polyisoprene condom / 2414485
Method of producing compound synthetic polyisoprene latex which is suitable for making latex films involves (a) compounding synthetic polyisoprene latex with suitable compounding ingredients, (b) maturating the latex and optionally (c) storing the latex. Steps (a), (b) and (c), if included, are carried out at temperature lower than 20°C in order to minimise latex precuring.
Hydrophilic polymers with reversed phase and use thereof in water-swellable elastomeric compositions / 2411262
Invention relates to water-swellable compositions, as well as to preparation and use thereof. The water-swellable composition contains: (a) 5-70 wt % water-swellable material which is hydrophilic polymer microparticles, (b) 30-95 wt % non-water-swellable thermoplastic polymer or elastomeric material. The hydrophilic polymer microparticles have volume-average diametre not greater than 2 mcm. The composition can be used to produce sealants. The water-swellable composition is prepared by mixing (a) and (b).
 Perfected method of continuous production of composition containing rubber, hydrocarbon polymer and solvent / 2372359
Proposed method relates to method of continuous fabrication of adhesive composition containing rubber (20), hydrocarbon polymer and solvent (26). Proposed method comprises using at least two two-auger extruders (10a, 10b) arranged in succession. Note that temperature at outlet of each extruder is lower than solvent boiling point and that solvent is added in parts to multiple points located behind initial section of first extruder and to multiple points located along second extruder. Note here that a part of solvent (26) is added to composition coming from 10a and before it enters 10b. The extruders above can represent extruders running in opposite directions, or preferably, in one direction.
 Stabilised with protective colloid polymeric dispersible powders / 2339592
Polymeric dispersible powders, stabilised with protective colloid, contain, (a) at least one polyvinyl alcohol with viscosity μ1 according to Heppler viscosimeter maximum 3 mPa·s, and (b) at least one polyvinyl alcohol with viscosity μ2 according to Heppler viscosimeter from 4 to 25 mPa·s, value of suspended viscosity μ"ц" of protective colloid according to Heppler viscosimeter constitutes maximum 6 mPa·s. Claimed invention also relates to method of obtaining such polymeric dispersible powders, their application in construction chemistry products, in combination with hydraulically setting binders, for instance cement, gypsum and liquid glass, to application in production of construction glues, plasters, putties, etc, as well as to application in mortars for guniting and jetcrete, used in ground and underground construction, as well as for tunnel revetment. Dispersible powders contain for their stabilisation mixture of low- and high- viscous polyvinyl alcohols, as result powders have better qualities which positively add to their processibility, such as resistance to caking, bond strength during stretching, for instance with polystyrol, redispersibility and fluidity.
Composition for production of oil-extended polyvinyl alcohol cryogel, process of its obtainment and oil-extended cryogel / 2326908
Invention concerns composition for production of oil-extended polyvinyl alcohol cryogel, containing (mass part): 3-30 of polivinyl alcohol, 2-43 of liquid hydrophobic filler - vegetable or mineral oil, and 52-95 of water. This invention also concerns process of obtaining oil-extended polyvinyl alcohol cryogel, as well as the said cryogel obtained by this process. Definite component ratio of the said composition enables regular distribution of liquid hydrophobic filler particles over the whole volume of oil-extended polyvinyl alcohol cryogel formed of such composition. As a result, the cryogel shows more stable physical and mechanical properties at any point. Besides, liquid oil used as hydrophobic filler predetermines production of composite polymer materials with various properties and applications on the basis of a single principle. The said process also does not involve organic dissolvent and hence does nor produce ecologically hazardous sewage. Oil-extended cryogel is applied in medicine as implant, wound-healing covers; in cosmetology as nutritious masques, applicators, auxiliary substances for wrapping; in techniques for production of self-lubricating resilient articles of complex shape, etc.
Fluoropolymers with improved shrinkage by consolidation / 2326907
Invention describes consolidatable composition consisting of: a) fluoropolymer with co-polymerised blocks obtained from: i) CF2=CF-Rf where Rf is fluorine or perfluoroalkyl C1-C8; ii), at least ca. 10 mol percent of hydrogen-containing olefine C2-C9, depending on the total number of molecules of the said CF2=CF-Rf and the said olefine; iii) optionally, CX2=CX-R where each X independently denotes an H, F or Cl atom, while R is a halogen or alkyl or alkenyl group C1-C8, which can contain one or more ester bonds; iv) optionally, bromine-containing consolidation monomer; v) bromine-containing salt; b) optionally, peroxide consolidation catalyst; and c) optionally, linking co-agent where the said fluoropolymer contains two or more average bromine atoms, including more than one end bromine atom per fluoropolymer chain, and where fluoropolymer is practically free from chain transport medium residues. Moreover, the invention describes process of obtaining such fluoropolymer compositions and goods with them.
Dual oral care product / 2476200
Group of inventions refers to dual tooth brushing compositions and methods for using them. The presented dental care composition contains a first ingredient containing a calcium source in the form of dicalcium phosphate, a second ingredient containing at least one anion source wherein one of the anion sources represents a fluorine ion source wherein at least the second ingredient contains arginine or its salt with the first and second ingredient are separated from each other until supplied and combined for dental application. There are also presented a method of oral care and a method of elimination or relief of discomfort and pain related to dentine hypersensitivity with the use of said composition.
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FIELD: medicine, pharmaceutics. SUBSTANCE: invention refers to chitosan carboxyalkylamide hydrogel and may be used for cosmetic and dermatological treatment of skin burns. Chitosan carboxyalkylamide hydrogel of pH close to that of skin and making 6.5 to 7.2 contains 40 to 90 mole % of the groups of N-carboxyalkylaminde D-glucosamine of formula (I) EFFECT: preparing the anhydrous product of chitosan carboxyalkylamide prepared by hydrogel dehydration. 12 cl, 1 dwg
The present invention relates to the thixotropic hydrogel carboxylamide chitosan, intended for the cosmetic and dermatological treatment of skin burns. Along with cellulose, chitin is one of the most common natural polymers. It can be obtained for example from an external skeleton of some crustaceans and insects. Chitin consists of structural groups of N-acetylglucosamine interconnected relationships of β-1,4. Chitosan is the product of the deacetylation of chitin hydrolysis the hydrolysis of at least a part of the groups of N-acetylglucosamine converted into glycosaminogl. It was decided to define the term "chitosan" chitin with a degree of deacetylation of more than 50%. The deacetylation of chitin usually increases the solubility of the polymer in water, but this increase in solubility is dependent on pH; in other words, chitosan with a high degree of deacetylation is soluble only in acidic medium, generally at a pH below 6, when protonated sufficient part of his functional amino groups. Long known for excellent biocompatibility of these two polymers and biodegradable chitin and, to a lesser extent, chitosan. In addition, have been described bacteriostatic and fungistatic properties of these polymers. In addition, there is the capability in order to encourage scarring skin lesions, acute or chronic, superficial (epidermal) or deep, it is affecting the dermis. So, an application for French patent FR 2736835 discloses a dressing for chronic wounds based on chitin, the deacetylation of which is at least equal to 40%. This dressing is a transparent, relatively rigid hydrogel. In the international application WO 03/068281 disclosed the bandage on the basis not of chitin and chitosan, the degree of deacetylation of which at least 60%, preferably ranging from 94 to 98%. This armband also represents the plate thickness from 1 to 10 mm, in certain cases mobilisierung on a substrate having a sufficient mechanical strength to be able to manipulate and apply to the wound, you want to protect and heal. And, finally, in patent US 6124273 disclosed hydrogel chitin-based mesh structure comprising the active substance, in particular, protein intended for release into the damaged area. The purpose of the present invention was to use the known properties of chitosan, contributing to the scarring, though it is not presented in the form of a bandage on the basis of a relatively rigid hydrogel described in the aforementioned documents, which OTP is destroying the existing modern technologies, and in the product form, easier to use, which can easily be applied to the skin, for example, in the form of creams or ointments that are so necessary in the processing of relatively large areas of the skin. Such use will allow you to apply chitosan not only as dressings for medical purposes, but also for cosmetic treatment of minor superficial burns, formed, for example, by prolonged exposure to the sun. In this regard, the applicant has set itself the task to develop thixotropic hydrogel chitosan, that is, the physical gel (unlike chemical gel, in which points forming a mesh structure, formed by covalent bond), which in the rest state has the consistency of a gel, but when the application's efforts slice becomes less viscous, allowing it to easily spread over large areas of skin. the pH of the hydrogel should be fairly close to the pH of the skin, preferably to be from 6.5 to 7.2. Indeed, if the pH values outside the specified range, it is compatible with use on healthy skin, the applicant found that rapid and effective relief of pain caused by superficial or deep burns, was achieved only by setting the pH of the product to the value close to the pH of the skin. In this case the applicant has faced the problem the insufficient solubility of chitosan with a low degree of deacetylation in this pH range. Indeed, by neutralizing the acidic solution of chitosan at a pH of about 5 to 6 was formed precipitate, and the preparation of thixotropic hydrogel was impossible. The present invention is based on the discovery of the possibility of preparation of thixotropic hydrogel having the consistency of a cream or ointment, with a pH close to the pH level of the skin (pH=6,9), by converting at least 40%, preferably at least 50% of the functional amino groups glucosamine groups of chitosan with a degree of deacetylation of at least 85%, in the functional carboxyl group (COOH), causing them to react with the anhydride of a suitable dibasic carboxylic acids. Therefore, an object of the present invention is a thixotropic hydrogel carboxylamide chitosan, characterized in that it has a pH close to the pH of the skin, comprising from 6.5 to 7.2, preferably from 6.8 to 7.0, and the fact that the mentioned carboxyaniline chitosan includes from 40 to 90% by moles, preferably from 50 to 80% by moles, and more specifically from 50 to 75% by moles, with respect to the total number of groups (A) and (B)groups of N-carboxymethylamino D-glucosamine formula (I) (group (A)),
where n is an integer from 1 to 8, preferably from 1 to 4, and more specifically, equal to 2, or Addie is active salt of physiologically acceptable bases last, - from 60 to 10% by moles, preferably from 50 to 20% by moles, more specifically, from 50 to 25% by moles, with respect to the total number of groups (A) and (B)protonated groups of D-glucosamine formula (II), (group (B)
in which R represents an alkyl residue with C1-4and from 5 to 15% by moles, with respect to the total number of groups (A), (B) and (C), groups of N-acetyl-D-glucosamine (group (C)). As indicated above, the hydrogel should be thixotropic, that is, to have a viscosity, which in the absence of efforts to cut tends to infinity, in other words, the gel does not flow or flows very slowly. When the efforts of the slice, for example, when the distribution on the skin its viscosity decreases. The Brookfield viscosity thixotropic gel according to the invention, measured using a Brookfield viscometer (needle No. 4, 30-60 rpm./min, 20°C), is preferably from 200 to 8000 sandypaws, more specifically, from 300 to 1000 centipoise. Thus, chitosan, forming a hydrogel of the present invention, an additive salt of the acid product of acetylation of chitosan anhydride dibasic carboxylic acids with C3-10. The acid used for the oxidation of functional amino groups of chitosan, which has not entered into reaction with the anhydride is an organic acid with the formula RCOOH, where R represents alkyl the second group with C 1-4. As the organic acid for the oxidation preferably acetic acid is used, thus, R is represented by methyl group. This acid is usually used by dissolving chitosan in water before the reaction with the anhydride of the acid and neutralizing carboxylamide chitosan, obtained as reaction product. To obtain a hydrogel appropriate consistency concentration carboxylamide chitosan is preferably from 0.5 to 3% by weight, more specifically from 1 to 2% by weight. At concentrations below 0.5% usually get gel, with a too low viscosity, which flows even in the absence of efforts to cut, and the concentration of more than 3% by weight get too hard gels such as those described in documents FR 2736835 and WO 03/068281, and which are not amenable to distribution on large parts of the surface of the skin. It is obvious that an adequate concentration of carboxylamide chitosan above, depend on the average molecular weight used derivatives of chitosan. The larger the mass of the polymer, the lower the concentration required to obtain a suitable consistency. Carboxylamide chitosan forming the hydrogel according to the invention generally have an average molecular weight of from 10,000 to 800,000 daltons, preferably from 50000 to 200000 daltons. is the molecular weight can be reduced in the preparation of the hydrogel due to the treatment of aqueous suspensions or acidified solution of chitosan by hydrogen peroxide. The hydrogel of the present invention preferably contains in addition to water structuring additive selected from polyhydric alcohols and designed to promote good distribution of gel on the skin surface. The hydrogel according to the invention contains at least one polyhydric alcohol is preferably from 0.1 to 40% by weight, more specifically from 0.1 to 20% by weight. The preferred polyhydric alcohol is glycerol. Hydrogel carboxylamide chitosan according to the present invention has an immediate analgesic effect, possibly due to the effect of hydration and cooling, as well as due to the absence of any irritating properties due to acidic or alkaline pH. This analgesic effect can be enhanced and/or extended synergistic effect by including in the hydrogel according to the invention is an extract of Calendula officinalis plants, known for its properties to contribute to scarring. The applicant has obtained excellent results by applying water-glycerin extract of Calendula officinalis in a concentration of from 0.2 to 0.5%. In the long term cosmetic use of hydrogel and the product of its dehydration and especially in the future dermatological use the above product dehydration, it is desirable to have a sterile hydrogel samples, PI is diversified with pharmaceutical use. Sterilization of the hydrogel is preferably in an autoclave or by exposure to sterilizing radiation, for example, a sufficient dose of gamma radiation. In a specific implementation method of the present invention, the hydrogel Packed in the form of single doses to prevent bacterial contamination as a result of prolonged storage after opening. In addition, an object of the present invention is a method for preparing a hydrogel as described above. This method includes the following successive stages: stage 1 - preparation of acidified aqueous solution of chitosan with a degree of deacetylation of 85 to 95%, with pH specified solution is in the range from 4.5 to 5.5, and is adjusted by adding an organic acid having the formula R-COOH, where R represents an alkyl group with C1-4preferably metal group, stage 2 - the reaction of the thus obtained additive salt of chitosan with acid in aqueous solution with 0.5 to 1 mol per mol of group D-glucosamine (groups ()) anhydride of dibasic organic acids having the formula noos-(CH2)n-COOH, where n is an integer from 1 to 8, preferably from 1 to 4, and more specifically, equal to 2, then step 3 - adjustment of the pH of the thus obtained reaction solution is here adding a physiologically acceptable base, when pH is in the range from 6.5 to 7.2. The concentration of chitosan in the solution in step 1 is preferably from 5 to 150 g/l, more specifically from 10 to 50 g/l, preferred way of implementing the appropriate number deacetylating chitosan in the form of powder is transferred into a state of suspension in purified water under stirring and slowly add the organic acid, preferably in a quantity equimolar to the number glucosamine groups. This step is performed preferably at ambient temperature, it may take several tens of minutes. One of the variants of this stage is that first acidified water by adding the appropriate amount of acid and then injected chitosan. After or before this stage of dissolution by acidification can add a small amount of hydrogen peroxide intended, if necessary, to reduce the molecular weight of chitosan due to oxidation of the separation of macromolecular skeleton. The amount of hydrogen peroxide is preferably from 0.01% to 0.03%. The reaction of the anhydride of dibasic acid is preferably carried out at temperatures from 20°C to 30°C with stirring over a period of time of, for example, from 45 minutes to 90 minutes. The anhydride can be added for two or for escolares, and in between additions, the solution can be neutralized by the introduction of the Foundation. After adding the anhydride and after the greater part of it came into the reaction solution gradually neutralize the diluted aqueous base, for example, a dilute solution of soda or potash, making sure not to cause precipitation of chitosan precipitates at too rapid addition of the base. Thus obtained product is a hydrogel according to the invention, and the need for further stages of processing or concentration no. In addition, an object of the present invention is the use of hydrogel-based carboxylamide chitosan described above for the cosmetic treatment of burns of the first degree and Nematoda burns, i.e. superficial second-degree burns by applying the above-mentioned hydrogel on the area of the burn. The hydrogel used by simply coating on the surface of the affected skin once or several times a day until the disappearance of the damage. We are not talking about dermatological treatment, because the hydrogel is applied on burns of the first degree or Nematoda burns second degree, operates exclusively at the level of the epidermis and not in contact with the underlying dermis. Cosmetic composition comprising a hydrogel according to the invention may includes the ü in addition to his other cosmetically active substances or additives, in particular, such as flavoring agents, coloring agents, structuring agents. During studies on the establishment of the above-described hydrogel, the applicant has found that the hydrogel can be dehydrated by known methods, such as lyophilization, spray drying, spray, and that the anhydrous product can be used in an unaltered state without prior recovery by adding water for cosmetic purposes on the burns of the first degree or Nematoda burns second degree, and an additional advantage is that it is perfectly suitable for dermatological use on weeping burns, that is, on a deep second degree burns and third degree burns. Indeed, the product of dehydration of the hydrogel provided that it has a sufficiently fine particle size, easily glides onto skin as the hydrogel from which it was prepared, analgesic effect and promotes scarring. Surprisingly, the products of dehydration of the hydrogel according to the invention is likely to penetrate the skin without leaving visible traces. Thus, an object of the present invention is also anhydrous product-based carboxylamide chitosan, obtained by dehydration of the above-described hydrogel. By way of dehydration mo is et to be any known method of dehydration by evaporation of water from the composition under vacuum and/or by heating. The applicant has received excellent products by lyophilization or spray drying, and therefore, the method of dehydration should be preferably selected from the last two. The object of the present invention is also referred to the anhydrous product as a medicine and as a medical device, preferably for local use and intended preferably for the treatment of deep moist second-degree burns and third degree burns. And, finally, the object of the present invention is a cosmetic composition and dermatological composition containing the above anhydrous product. Example 1 The method of preparation of the hydrogel carboxylamide chitosan according to the invention In a tank with a volume of 50 liters poured 36 liters of purified water and added slowly with stirring at a speed ranging from 2000 to 3000 rpm 926,6 g of chitosan powder of Khitomer (Kitomer) (Marinara - Marinard) with a degree of deacetylation 94,4% and humidity 2,87%. After a quarter hour of mixing in a tank add 319 g of acetic acid (approximately 1 molar equivalent relative to the number glucosamine groups of chitosan) and continue to stir at ambient temperature for several minutes. Then add 0.1 g 30% H2O2and astovl the Ute mixture at rest for approximately 1 hour. Then add to the mixture with vigorous stirring to about 133 g of succinic anhydride (about 0.30 molar equivalent relative to the number of glucosamine chitosan) and continue to mix for about 30 minutes. The resulting solution was gradually neutralized by slowly adding with stirring and within about 15 minutes to about 160 g of soda, dissolved in 1.5 liters of water. Repeat the step of adding succinic anhydride and neutralization, ensuring that the pH of the solution did not go beyond the intended final level of 6.5 to 7.2. After performing the above operations are provided about 39 liters of gel ready to use or ready to be processed through a stage of dehydration. Example 2 Method of preparation of water-glycerin gel that contains calendula extract Mix 1.5 liters of water and glycerin extract of Calendula officinalis with 3.5 liters of glycerol corresponding to the requirements of the European Pharmacopoeia, then poured 6 liters of water. Thus obtained solution is mixed with 39 liters hydrogel prepared in example 1. Then, the thus obtained product is subjected to irradiation with gamma radiation at 25 kGy. Example 3 The treatment of deep second-degree burns, the product of dehydration based hydrogel Erased the local powder, obtained by spraying hydrogel prepared as described in example 1, consisting of spherical particles ranging in size from 10 to 30 μm, was applied at three deep burns of the second degree, caused by laser treatment, on the back of the hand. The burns were approximately 5 mm in diameter. The fourth control burn, identical to the other three, did not receive any treatment. The scarring of the control not treated burn up to his disappearance has gone from three to four weeks. Three burns that were treated for 6 times on the first day and 2 times during the next day, had no signs of inflammation after 48 hours, and after 4 days were invisible. The pain was gone after the first application. The drawing shows a photograph of the rear of the brush 48 hours, to the left of the control burn, right three processed burn. Example 4 Treatment of burn first degree of the hydrogel Handled back brush, scalded with boiling water (first-degree burns), by applying a hydrogel of example 1 immediately after the burn (after less than 5 minutes), then after about half an hour and again after 2 hours. The pain stopped after the first treatment. Brush remained red for approximately 6 hours. The next day, no trace of the burn is gone. 1. Hydrogel carboxylamide chitosan, articulating the different topics it has a pH close to the pH level of the skin, comprising from 6.5 to 7.2, and the fact that the mentioned carboxyaniline chitosan comprises from 40 to 90% by moles, preferably from 50 to 80% by moles, and more specifically from 50 to 75% by moles with respect to the total number of groups (a) and (b) groups of N-carboxymethylamino D-glucosamine formula (I) (group (A)) 2. The hydrogel according to claim 1, characterized in that R is represented by methyl group. 3. The hydrogel according to claim 1, characterized in that it has a pH from 6.8 to 7.0. 4. The hydrogel according to claim 1, characterized in that the concentration of carboxylamide chitosan ranges from 0.5 to 3% by weight, preferably from 1 to 2% by mass. 5. The hydrogel according to claim 1, characterized in that it contains, in addition, less than the least one polyhydric alcohol, preferably glycerol, 0.1 to 40% by weight, preferably from 0.1 to 20 mass%. 6. The hydrogel according to claim 1, characterized in that it additionally contains a water-glycerin extract of Calendula officinalis. 7. The hydrogel according to claim 1, characterized by the fact that it is sterile. 8. The hydrogel according to claim 1, characterized by the fact that its Packed in the form of single doses. 9. A method of making a hydrogel according to any one of the preceding paragraphs, characterized in that it includes the following successive stages 10. Applying a hydrogel according to any one of claims 1 to 8 for the cosmetic treatment of burns first-degree and superficial Nematoda second-degree burns by applying the above-mentioned hydrogel on the area of the burn. 11. The anhydrous product-based carboxylamide chitosan, obtained by dehydration of the hydrogel according to any one of claims 1 to 8, the method of dehydration is preferably selected from among lyophilization and spray drying. 12. The anhydrous product according to claim 11 as a drug, preferably as a medicinal product intended for the treatment of deep moist second-degree burns and third degree burns.
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