Compositions containing natural honey and compositions preparation method. RU patent 2465784.

IPC classes for russian patent Compositions containing natural honey and compositions preparation method. RU patent 2465784. (RU 2465784):

A23L1/08 - Honey; Honey substitutes

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Method implies melting honey which is prepacked in a dry-air heating chamber during 10-14 hours so that temperature of the melted honey is maintained in the range of 50-55°C, and honey humidity is kept constant. Then melted honey is poured from the container into the collecting jar through the mesh filter with holes diameter of 2-3 mm which is covered with sieve or gauze. Afterwards honey refiltering, settling for 8-12 hours (45-50°C), removing foam with impurities, holding it for 3-4 days, reheating and returning the taken away honey follow. After settling honey is supplied to the mixer where nuts and/or seeds kernels or dried fruits are additionally introduced to it. Nuts and/or seeds kernels are beforehand inspected, washed, dried and crushed down to the size of 1.5-3 mm. Dried fruits are steeped beforehand in cold water for 1-2 hours, washed, inspected, rinsed with shower, dried and crushed down to the size of 1.5-3 mm, and the crushed mass is laid out in a layer 5-10 mm thick and treated with bactericide irradiator for 2-3 minutes. The obtained honey-nut or honey-fruit mixture is homogenised for 5-10 minutes producing paste which is then packed and sealed.

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Method stipulates addition to initial natural honey warmed up to the temperature of 30-60°C of fructose syrup of the same temperature with the fructose content 80-85% in the amount of 10-100% to the weight of honey, blending for 10-15 minutes and cooling down to the storage temperature.

Method for bioactive product collection from canned animal-origin raw materials (versions) / 2345573
Method for bioactive product collection includes unossified antlers deskinning, grinding, wetting and subsequent extraction. Wherein canned unossified antlers and deer by-products such as spleen, liver, embryos and deer penis with testicles in the form of fine powder or soot. Extraction is performed using natural honey in water bath at 45-50°C in the raw material:extractant ratio 1:10 or 1:20. As a version, extraction is performed by means of natural honey at 45-50°C together with exposure to 25 KHz ultrasonic field in the material:extractant ratio 1:10 or 1:20.

Dietary supplement / 2360448
Invention is related to food industry, in particular, to biologically active additives. Biologically active additive to food contains honey extract of walnuts of milky-wax ripeness. Walnuts and honey are taken in ratio 1:3, extraction lasts for 42 days. Additionally, lactulose concentrate is added in quantity equal to quantity of honey extract.

Dietary supplement / 2363268
Dietary supplement contains (taken for 100 kilos): honey extract of pumpkin sprouted seeds - 49.75 kg, lactulose concentrate - 50 kg and apple acid - 0.25 kg. Pumpkin seeds are sprouted on milk whey for preparation of honey extract. Honey extraction is performed during 42 days in dark place with ratio of seeds and honey 1:2. Supplement is a powerful bifidus-factor, preventive measure for cardiovascular diseases, source for replenishment of body energy costs, compensation of mineral and vitamin insufficiency.

FIELD: food industry.

SUBSTANCE: inventions may be used in food products and medical remedies. According to the first version, the composition includes natural honey and a chelating agent inhibiting activity of cellulose contained in honey. In accordance with the second version, the composition additionally contains a carrier wherein honey is soluble, the chelating agent is chosen from the group consisting of EDTA, phytic acid and their mixtures. The third version of the composition envisages presence of natural honey, a chelating agent and a cellulose polymer. The method for production of the first version of the composition envisages mixing natural honey with a chelating agent and optionally - the mixture heating.

EFFECT: inventions allow to produce natural honey containing compositions usage whereof in products containing cellulose polymers ensures the products stability due to prevention of cellulose polymers degradation.

27 cl, 1 dwg, 25 ex

The technical field to which the invention relates

The present invention relates to aromatic compositions containing natural honey and chelating agent, and compositions containing the specified aromatic compositions and cellulose polymer. Also provided ways of preparation of compositions in accordance with the present invention.

The level of technology

Honey is a useful and important flavouring substance and has some medicinal plant and useful effects. Natural honey increasingly widely used in medicines and in the composition of food products and beverages. On the stability of such songs, if they contain natural honey, can influence the components of natural honey. For example, it was shown that honey is a natural effect of the collapse of starch (amylose and amylopectin), caused by the presence of amylase is the enzyme that breaks A1-4 relationship between glucose groups (Babacan, S. et al (2002), Honey Amylase Activity and Food Starch Degradation 67(5), pp 1625-1630).

The inventors of the present invention found that the application of honey in a composition, containing cellulose polymer, unlike molecules starch-based, you can observe the decomposition of cellulose polymer. This collapse was not associated with amylase activity in natural honey, because amylase does not impact significantly on cellulosic polymers. The inventors of the present invention has determined that the presence of cellulase enzymes in natural honey is the cause of the collapse of cellulosic polymers. Haven't informed about the presence of cellulase in natural honey. Although called a mixture of compounds that can break down cellulose, cellulase, it actually consists of more than one enzyme, including β-1-4-glucanase and beta-glucosidase (see image below).

The use of honey in combination with cellulosic polymers led to the lack of stability end of the composition, that, in General, is defined as the loss of viscosity of the composition. There is therefore a need in compositions and perfumes, contains natural honey, and methods of preparation, the application of which, in combination with cellulosic polymers, natural honey does not lead to the collapse of cellulosic polymers and the resulting instability of the composition.

Summary of the invention

The present invention provides a composition on the basis of honey, essentially consisting of:

a) natural honey, containing at least one cellulase enzyme; and

b) chelating agent.

Additionally, the present invention provides a composition comprising:

a) natural honey, containing at least one cellulase enzyme;

b) chelating agent; and

c) cellulosic polymer.

Additionally, the present invention provides a method of preparation of the composition, which contains natural honey, including the stage of mixing chelating agent with natural honey, containing at least one cellulose enzyme and optional media. Compositions and methods of cooking provide a composition that contains natural honey, which have increased stability.

Brief description of drawings

On the Figure 1 shows the loss of viscosity, associated with the collapse of sodium carboxymethyl cellulose in the system that contains natural honey, and inhibition of the specified collapse of polymer and viscosity loss in the application processing chelating agents.

Detailed description of the invention

As used in this application, all percentages represent mass percentage content, unless otherwise noted. All the temperatures are given in Celsius (C), unless otherwise indicated.

The present invention provides a composition on the basis of honey, consisting essentially of pure honey, containing at least one cellulose enzyme and chelating agent. Composition of honey may be made in the form of aromatic compositions by combining natural honey and chelating agent with the media. Additionally, the present invention provides a composition comprising natural honey, which contains at least one cellulose enzyme in combination with chelating agent and cellulose polymer.

Natural honey

Composition, aromatic compositions and methods of cooking in this application require natural honey. As used in this application, the term "natural honey" includes honey produced by bees (Apis mellifera L.) or other insects from the nectar of plants or from secretions of living parts of plants that collect bees, transferred through merger with their own specific substances, lay, dehydrate, store and leave in cells to Mature. Natural honey must contain at least one cellulose enzyme.

Composition of honey in this application, consisting essentially of natural honey and chelating agent, contains natural honey. When used in the final composition in combination with cellulose polymer natural honey preferably present in quantities from about 0.1% to about 25% by weight of the composition. Preferably, the composition contains from about 0.1% to about 15%, even more preferably, from about 0.1% to about 10% of natural honey mass composition. In the other concrete implementations of the song, intended for use in food and medicines contain from 5% to 70% natural honey mass composition.

Chelating agent

Composition of honey, aromatic composition of honey and composition in accordance with the present invention also include chelating agent. Not wishing to be bound by theory, believes that chelating agent is acting, linking metal-cofactor that is contained within the Quaternary structure cellulase enzyme that is present in natural honey. As a result, cellulase enzyme partially denaturiruet, thereby reducing its enzymatic activity.

As used in this application, the term "chelating agent", including compounds and substances, means the molecule containing two or more electron-electron atom, which can form the coordinating communications with a single metal ion. Imply that the term "chelating agent" includes chelating agent and its salts. For example, the term "chelating agent" includes citric acid and its salt form.

The most common and widely used chelating agents are co-ordinated with metal atoms through oxygen and nitrogen donor atoms, or through both the atom. Other less common chelating agents are coordinated through the sulfur in the form of-SH (tilnik or mercapto) groups. After the formation of the first coordination each subsequent donor atom, which is bound, forms a loop containing metal atom. Chelating agent can be bidentate, tridentate, tetradentate etc. depending on whether it contains two, three, four or more donor atoms capable of linking the metal atom. Cm. Kirk-Othmer Encyclopedia of Chemical Technology (4 th ed. 2001).

Chelating agent may be soluble or insoluble in natural honey, until it easily accessible to complexing with ions of metals contained in food. Different classes of chelating agents are acceptable for use in the present invention. Non-limiting examples of such classes include polyphosphates (for example, sodium tripolyphosphate, hexametaphosphate acid, acid sodium pyrophosphate, sodium pyrophosphate, pyrophosphate tetrandra, sodium hexametaphosphate, metaphosphate sodium); aminocapronova acid (for example, ethylenediaminetetraacetic acid (EDTA), 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraaxiology acid (EGTA), ethylenebis(oksietilnye)-tetraaxiology acid (WARTA), N-(hydroxyethyl)-etilendiamindioksimom acid (HEDTA), diethylenetriaminepentaacetic acid (DTPA), N is dihydroxyethylene (2-HxG), ethylenebis(hydroxyphenyl-glycine) (EHPG), glutamic acid, aspartic acid, glycine, lysine); 1,3-diketones (for example, acetylacetone, triflluoroacetylacetone, thenoyltrifluoroacetone, ascorbic acid); hydroxycarbonate acid (for example, tartaric acid, citric acid, malic acid, gluconic acid, frolovoy acid, lactic acid, glucuronic acid); poliaminy (for example, Diethylenetriamine, triethylenediamine); aminoalcohols (for example, triethanolamine, N-gidroksietilirovanny, aminotetralin (EEA); phenols (for example, desulphurisation, hronotroponuu acid); aminophenols (for example, oksanalovely acid); Schiff bases (for example, disalicylic aldehyde 1,2-PROPYLENEIMINE); tetrapyrrol (for example, tetraphenylporphine, phthalocyanine); silicates (silicate of aluminium, calcium, calcium silicate, silicate of sodium, sodium aluminosilicate calcium (hydrate), tricalcium silicate); sulphur compounds (e.g., potassium ethyl xanac, sodium diethyldithiocarbamate, diarilditiophosphat acid, thiourea, magnesium sulfate); synthetic macrocyclic compounds (for example, HEXAMETHYL-[14]-4,11-N 4 , 2,2,2-criptat); polymers (for example, polyethylenimine, polymethacrylate, poly(p-universityindustry acid)), phosphonic and bisphosphonic acid (for example, nitrilotrimethylphosphonic acid, ethylenediaminetetra-(merentseva acid), hydroxyethylidenediphosphonic acid).

The number chelating agent that is present in the composition of honey, aromatic compositions on the basis of honey and the composition depends on the number of present natural honey and will additionally depend on the specific selected chelating agent or chelating agents (i.e. mixtures of chelating agents). Chelating agent, in General, must be present in number from about 0.01% to about 5% by mass, natural honey, preferably from about 0.1% to about 3% by weight of honey. If chelating agent selected from the group consisting of EDTA, phytic acid, citric acid, malic acid, tartaric acid, lactic acid, adipic acid, succinic acid, aspartic acid, glutamic acid, lysine and their mixtures, chelating agent, preferably present in number from about 0.01% to about 5% by weight of honey. Preferably, if chelating agent choose from EDTA, phytic acid, or mixtures thereof, chelating agent is present in number from about 0.01% to about 1% by mass, natural honey.

Cellulosic polymer

Composition in accordance with one implementation of the present invention contain cellulose polymer. Cellulose polymer, in General, used for thickening or structure formation compositions in accordance with the present invention. As used in this application, the term "cellulosic polymer" means a polymer containing cellulose Monomeric frame, where the pulp and monomers may not necessarily contain chemically modified functional groups. Acceptable non-limiting examples of chemical modifications include changing the hydroxyl functional group. Non-limiting examples of cellulosic polymers for use in this application include hypromellose, hydroxyethyl cellulose, methylcellulose, microcrystalline cellulose, carboxymethylcellulose, metilgidroksipropilzelluloza, azettftalat cellulose, ethylcellulose, gidroksipropilzelluloza and their mixtures and their traditionally used salt. Preferably, cellulose polymer contains carboxymethylcellulose and its traditionally used salt.

Composition in accordance with the present invention preferably contain a sufficient number of cellulosic polymer to maintain the viscosity of the composition from approximately 50 JV to approximately 5000 SP, preferably from approximately 100 JV to approximately 1000 SP. As used in this application, the measure viscosity at 25 C, using Brookfields RVDV-II+ with funnel 51 and tip for sampling at 10 rpm

Composition in accordance with the present invention preferably contain from about 0.1% to about 10% cellulose polymer mass composition, preferably from about 0.1% to about 5% by weight of the composition.

Composition in accordance with the present invention may not necessarily optionally contain additional thickeners, provided that there is also cellulosic polymer. Acceptable non-limiting examples of thickeners, acceptable for use in this application in conjunction with cellulose polymer, include natural polymers, polymer derivatives of cellulose, polyvinylpyrrolidone (PVP), dekstranov polymers, polietilenoksidnoy polymers, including Polyox-600, thermally reversible polymers, polymers, sensitive to the ions, copolymers polimetilvinilovogo ether and maleic anhydride and their mixtures. Polymer derivatives of cellulose and thermally reversible polymers are preferred.

Specific non-limiting examples of natural polymers, are acceptable for use as polymers, giving viscosity, in this application include Cracovie gums, tragacantha gums, polymers on the basis of agar, xanthan gum, copolymers of alginic acid and sodium alginate, polymers chitosan, pectins, karraginana, pullulanase polymers, modified starches and their mixtures.

Specific non-limiting examples of polymers, sensitive to the ions, are acceptable for use as polymers, giving viscosity, in this application include Gerrit, Gellan gum, Calogel F and their mixtures.

Specific non-limiting examples of copolymers polimetilvinilovogo ether and maleic anhydride, are acceptable for use as polymers, giving viscosity, in this application include such copolymers, which is sold under the trade name Gantrez, including copolymers type Gantrez S and Gantrez MS.

Known polymers, giving viscosity, are acceptable for use in this application are selected from the group consisting of carboxyfullerenes, carboximetilovy polymers, polyvinyl acrylic acid, cross stitched with allyl ether pentaerythritol, homopolymers acrylic acid, cross stitched with allyl ether of sucrose, homopolymers acrylic acid, cross stitched with diphenylglycine and their mixtures.

Media

Aromatic composition on the basis of honey in accordance with the present invention provides a composition on the basis of honey and media. The media can be any inert base, well-known specialists in the field of technology, is acceptable for use as media for flavouring ingredient. Such media are acceptable for admission into the person and their typically chosen so that flavouring ingredient, in this case, natural honey, is soluble in the media or mixed with it. Alternatively, the media can be selected in such a way that natural honey emulgelooe inside media. Non-limiting examples of media, are acceptable for use in fragrance compositions on the basis of honey in accordance with the present invention include, but are not limited to the above, propylene glycol, ethanol, water, or mixture thereof. Preferably, the media is from approximately 30% to approximately 95% by weight aromatic compositions on the basis of honey.

Form of composition

The present invention provides a composition comprising natural honey, chelating agent and cellulose polymer. Composition in accordance with this implementation can be in the form of medicines, food, drink, or ready premix ingredients for use in one of the above categories. Preferably, the composition is in the form of a medicinal product. The drug can be prepared in the form of syrup, capsules, filled with liquid, containing the standard dose of the medicinal product, centralcodeplan drops for the throat, etc., preferably in the form of syrup.

If music is a drug, then the composition preferably contains pharmaceutically active substance. Pharmaceutically active substance can be included in the composition as an active ingredient or as a combination of active ingredients. Pharmaceutically active substance preferably is particularly effective in the prevention and treatment of symptoms of colds and influenza-like States. Pharmaceutically active substance included in the pharmaceutical composition in accordance with the present invention in number from about 0.01% to about 60%, preferably from about 0.1% to about 20%, even more preferably from about 0.1% to about 10% by weight of the composition.

Non-limiting examples of active ingredients that are acceptable for use in this application include the active ingredients, which are pharmacologically classified as antitussives, antihistamines, nnegative antihistamines, decongestants funds, expectorant, mucolytics, analgesics, antipyretics and anti-inflammatory drugs, local anesthetics and their mixtures. Such active ingredients as more fully described in J.G.Hardman, The Pharmacologic Basis of Therapeutics, Ninth Edition, McGraw-Hill, New York, 1995. Preferably, pharmaceutically active material selected from the group consisting of protivokashlevami means, antiedematous funds, antihistamines, expectorant, mucolytics are presented or their mixtures. Preferably, pharmaceutically active material selected from the group consisting of protivokashlevami means of expectorants, mucolytics are presented, decongestants or their mixtures.

Specific non-limiting examples antitussive agents, are acceptable for use in this application include antitussive connections that are especially effective in treating symptoms of the common cold, such as coughing spasms. Acceptable specific antitussive agents include codeine, dextromethorphan, dextrophan, hydrocodone, noscapine, oxycodone, pentoksifillin and their mixtures. Dextromethorphan is the preferred antitussive agent. As used in this application, "dextromethorphan" means racemethorphan, (+-)-3-methoxy-17-methylmorphinan, d1-CIS-1,3,4,9,10,10A-hexahydro-6-methoxy-11-methyl-2H-10,4A-aminoethanoles and their pharmaceutical salts, including dextromethorphan hydrobromide. Dextromethorphan and its pharmaceutically acceptable salts are more fully described in U.S. patent number 5,196,436. Specific non-limiting examples of antihistamines, are acceptable for use in this application include acrivastine, azatadine, brompheniramine, brompheniramine maleate, chlorpheniramine, chlorpheniramine maleate, clemastin, cyproheptadine at, dexbrompheniramine, dimenhydrinate, diphenhydramine, diphenhydramine hydrochloride, hydroxyzine, meclizine, Veniamin, phenyltoloxamine, promethazine, pyrilamine, pyrilamine maleate, tripelennamine, triprolidine, doxylamine, doxylamine succinate and their mixtures.

Specific non-limiting examples resedation antigistaminnami means that are acceptable for use in this application includes astemizole, cetirizine, Bastin, feksofenadin, loratadine, terfenadine and their mixtures. Specific non-limiting examples of anti funds, are acceptable for use in this application include phenylpropanolamine, pseudoephedrine pseudoephedrine hydrochloride pseudoephedrine sulfate, ephedrine, phenylephrine, phenylephrine hydrochloride, and mixtures thereof. Specific non-limiting examples of expectorants acceptable for use in this application include ammonium chloride, guaifenesin, extract ipekakuany, potassium iodide and their mixtures. Specific non-limiting examples mucolytics are presented, are acceptable for use in this application include acetylcysteine, Ambroxol, Bromhexine and their mixtures. Specific non-limiting examples of analgesics, antipyretics and anti-inflammatory agents, are acceptable for use in this application include acetaminophen, aspirin, sodium salicylate, salicilamid, diclofenac, diflunisal, etodolac, fenoprofen, flurbiprofen, ibuprofen, Ketoprofen, Ketorolac, nabumetone, naproxen, piroxicam, caffeine, Ketorolac, indometacin, meclofenamic acid, SOKH-2 inhibitors, such as valdecoxib, celecoxib and rofecoksib, and their mixtures.

Optional ingredients

Water may be used in compositions in accordance with the present invention. In the present invention, the maximum amount of water is approximately 10%, preferably from about 1% to about 10%, preferably from about 5% to about 10% and even more preferably from about 5% to about 8% by weight of the composition.

Composition and aromatic compositions on the basis of honey in accordance with the present invention can optionally contain a buffer or mixture buffer agents. Non-limiting examples of acceptable buffer agents for use in this application include basic buffers, the value of RCA which is from 8 to 11, including triethanolamine, tromethamine, salts of amino acids, including alkaline salt glycine, glycylglycine, glutamine or other amino acids, alkaline phosphate salts, carbonate or their mixtures. Buffers ensure the sustainability of songs to changes in pH when breeding composition of saliva in the pH range from 8 to 10.

Sweeteners can optionally be added to the composition and aromatic compositions on the basis of honey in accordance with the present invention. Acceptable flavourings for use in this application include aspartame, saccharin and its salts, Sucralose TM (sells McNeil Specialty Products Co., New Brunswick, NJ); Prosvita TM (sells Virginia Dare Extract Co., New York, NY); Magnasweet TM (sells MAFCO Worldwide Corp., Licorice Division, Camden, NJ); glycyrrhizinate ammonium and its salts, Talin TM (coumadin) and its diluted products such as Talin GA90, (sells Talin Food Company, Birkenhead, England); and Acesulfame K or their mixtures.

Other fragrances that can be used in compositions and aromatic compositions on the basis of honey in accordance with the present invention, includes anise, peppermint, clove oil, eucalyptus, lemon, lime, honey lemon, red fruit, mint, grapefruit, orange, cherry, Cola, or their mixture.

Composition and aromatic compositions on the basis of honey in accordance with the present invention can optionally contain organoleptic funds. Acceptable non-limiting examples of organoleptic tools that are useful in this application are organoleptic the means selected from the group consisting of coolers, means that cause salivation, heating agents, or their mixtures. If these are available, they preferred to present the songs in number from about 0,001% to about 10%, preferably from about 0.1% to about 1% by mass of the composition.

Non-limiting examples of acceptable refrigerants include carboxamide, mentaly, thymol, camphor, and phenol, eucalyptus oil, benzyl alcohol, salicylic alcohol, ethanol, oil from the flowers clove and hexylresorcinol, ketals, diols and their mixtures. The preferred heating tools include thymol, camphor, capsicum, phenol benzyl alcohol, salicylic alcohol, ethanol, oil from the flowers clove and hexylresorcinol, ester of nicotinic acid, such as benzyl nicotinate, ketals, diols, capsicum and their mixtures.

The preferred refrigerants include parametersarea agents, such as N-ethyl-p-Menten-3-carboxamide (WS-3, which delivers Sterling Organics), described in U.S. patent number 4,136,163, issued on January 23, 1979, Watson et al. The preferred refrigerants are parametersarea agents, such as N-ethyl-p-Menten-3-carboxamide. Other preferred parametersinner agent is N,2,3-trimethyl-2-isopropylmalate known as WS-23, or a mixture of WS-3 and WS-23.

Additional preferred coolers are selected from the group consisting of menthol, 3-1-methoxypropan-1,2-diol, known as TC-10, which delivers Takasago Perfumery Co., Ltd., Tokyo, Japan, montepucianas known as MGA, which produces Haarmann and Reimer, Menthyl lactate, known as Freskaat®that produces Haarmann & Reimer, or their mixtures.

Method of preparation

Way in accordance with the present invention may be preferable to include additional stage where honey is heated or before, or after mixing chelating agent with natural honey, preferably after mixing chelating agent with natural honey. Stage of heating, in General, involves the heating of natural honey or mixture of natural honey and chelating agent to a temperature of approximately 90 C to 140 C, preferably from approximately 90 C to approximately 120 degrees C. Stage heating preferably has a duration of approximately 1 minute to approximately 60 minutes, preferably from approximately 1 minute to 30 minutes or more preferably from approximately 1 minute to about 10 minutes. Having no desire to be tied to theory, believe that at the stage of heating denatured cellulase enzyme, which is found in natural honey, so by disabling it. Cellulase enzyme, however, is quite stable and obviously due to the presence of the Central metal-cofactor that can denaturiruet for some period of time, even after exposure to high temperatures. The combination of heat treatment in the presence of the chelating agent or with the subsequent addition chelating agent leads to the fact that the Central metal-cofactor exposed to and more easily gelatinoasa chelating agent. Remove metal-cofactor inhibits refolding cellulase enzyme, resulting in more effective and permanent inhibition cellulase enzyme in natural honey.

Stage of heating can be implemented using the methods and equipment, well-known specialists in the field of technology, a non-limiting examples of which include autoclaving, vessels for heating that can withstand high pressure vessels for heating with the possibility of mixing. Preferably, the stage of heating is carried out in an autoclave with the possibility of mixing or other acceptable closed casing is sealed mixers.

Examples

Composition of honey

1 2 3 4

The percentage (%)

EDTA 0,001 0,01 0,1 1

Honey containing cellulase enzyme

99,999 99,99 99,9 99 Just 100 100 100 100

Method of preparation: heated to 110 OC-120C within 5-30 minutes in the mixer that will withstand high pressure, with or without

Composition of honey

5 6 7 8

The percentage (%)

EDTA 0,005 0,05 0,5 2

Honey containing cellulase enzyme

99,995 99,95 99,5 98 Just 100 100 100 100

Preparation method: mix within 5-30 minutes

Flavouring composition of honey

9 10 11 12

The percentage (%)

EDTA 0,001 0,01 0,1 1

Honey containing cellulase enzyme

50 50 50 50

Propylene glycol

49,999 49,99 to 49.9 49 Just 100 100 100 100

The way of reception: heated to 110 OC-120C within 5-30 minutes in the mixer that will withstand high pressure, with or without

Aromatic composition on the basis of honey

13 14 15 16

The percentage (%)

EDTA 0,001 0,01 0,1 1

Honey containing cellulase enzyme

50 50 50 50

Propylene glycol

49,999 49,99 to 49.9 49 Just 100 100 100 100

The way of delivery: mixed within 5-30 minutes

Composition from cough and cold

17 18 19 20 21

% wt./about.

Dextromethorphan HBR

of 0.133

0,000

of 0.133

0,000

Guaifenesin

1,333 0,000 1,333 0,000 1,333

Sodium carboxymethylcellulose

0,400 0,450 0,500 1,000 2,000

Polietilenoksid

0,100 0,100 0,100 0,100 0,100 Sucrose 37,000 37,000 37,000 37,000 37,000

Propylene glycol

5,20 5,20 5,20 5,20 5,20 Alcohol 5,00 5,00 5,00 5,00 5,00

Saccharin sodium

0,075 0,075 0,075 0,075 0,075

Sodium benzoate

0,100 0,100 0,100 0,100 0,100

Citrate dihydrate sodium

0,522 0,522 0,522 0,522 0,522

Anhydrous citric acid

0,338 0,338 0,338 0,338 0,338

PEG-40 stearate

0,300 0,300 0,300 0,300 0,300

Synthetic levomenthol

0,020 0,020 0,020 0,020 0,020

Flavor of honey (example 11)

0,50 1,00 3,00 5,00 10,00

Methoxypropanol (TK)

0,040 0,040 0,040 0,040 0,040

Verbena flavouring 97445-73

0,020 0,020 0,020 0,020 0,020

Water purified EP to volume

100% wt./about.

The way of reception: get viscous fluid by adding water to cellulose gum and polyethylene oxide.

Add sucrose.

Dissolve the buffer components in water and add to the mixture.

Add Propylene Glycol.

Add the active substance, PEG-40 stearate, alcohol and flavors.

Song for the relief of many symptoms

22 23 24 25

% wt./about.

Pseudoephedrine

30 mg 30 mg 0,00 30 mg

Acetaminophen

500 mg 0,00 500 mg 500 mg

Dextromethorphan HBR

of 0.133

0,000 0,000

Guaifensin

1,333 0,000 1,333 0,000

The hypromellose

0,50 0,00 0,00 0,00

Hydroxyethylcellulose

0,00 1,00 0,00 0,00

Gidroxiatilzelluloza

0,00 0,00 1,50 1,50

Polietilenoksid

0,100 0,100 0,100 0,100 Sucrose 37,000 37,000 37,000 37,000

Propylene glycol

5,20 5,20 5,20 5,20

Alcohol 96%

5,00 5,00 5,00 5,00

Saccharin sodium

0,075 0,075 0,075 0,075

Sodium benzoate

0,100 0,100 0,100 0,100

Citrate dihydrate sodium

0,522 0,522 0,522 0,522

Anhydrous citric acid

0,338 0,338 0,338 0,338

PEG-40 stearate

0,300 0,300 0,300 0,300

Synthetic levomenthol

0,020 0,020 0,020 0,020

Flavor of honey (example 15)

1,00 5,00 10,00 10,00

Methoxypropanol (TK)

0,040 0,040 0,040 0,040

Verbena flavouring 97445-73

0,020 0,020 0,020 0,020

Water purified EP to volume

100% wt./about.

The way of reception: get viscous fluid by adding water to cellulose gum and polyethylene oxide.

Add sucrose.

Dissolve the buffer components in water and add to the mixture.

Add propylene glycol.

Add the active substance, PEG-40 stearate, alcohol and flavors.

Sizes and values described in this application should not be interpreted as strictly limited the precise numerical values. Instead, unless otherwise noted, each such amount is intended to indicate how the values and functionally equivalent range around this value. For example, the size, described as "40 mm, is used to denote "approximately 40 mm".

1. The composition is intended for use in food and medicines, consisting essentially of: a. natural honey, containing at least one cellulase enzyme; and (b. chelating agent, and the composition contains from 0.01% to 5% of the chelating agent by weight of honey.

2. The composition according to claim 1, characterized in that the composition contains from 0.1% to 3% of the chelating agent by weight of honey.

3. The composition according to claim 1, wherein the chelating agent selected from the group consisting of polyphosphates, aminocapronova acids, 1,3-diketones, hydroxycarbonate acids, polyamines, phenols, Schiff bases, silicates, sulfur compounds, synthetic macrocyclic compounds, polymers, phosphonic and biphosphonate acids or their mixtures.

21. Method of preparation of compositions on any one of claims 1 to 5, including the state, which is mixed chelating agent with natural honey.

22. The method according to item 21, characterized in that additionally includes the stage at which heat specified natural honey or mixture of natural honey and chelating agent for temperatures from-50C up to 140 C.

23. The method according to article 22, wherein natural honey or mixture of natural honey and chelating agent is heated to a temperature of 90 C to 130 degrees.

24. The method according to item 23, wherein the specified stage heating is carried out after mixing chelating agent with natural honey.

25. The method according to article 22, wherein the specified stage heat lasts from 1 minute to 60 minutes

26. The method according to A.25, characterized in that the specified stage heat lasts from 1 minute to 30 minutes

27. The method according to article 22, wherein the specified stage heating is carried out in an autoclave or acceptable closed casing mixers that will withstand high pressure, with the possibility of mixing.