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Method for treatment of chronic inflammatory disease of uterus cervix and vagina

IPC classes for russian patent Method for treatment of chronic inflammatory disease of uterus cervix and vagina (RU 2278672):

A61P15/02 - for disorders of the vagina
A61K36/752 - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J0003000000; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L)
A61K36/61 - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J0003000000; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L)
A61K36/53 - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J0003000000; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L)
A61K35/02 - from inanimate materials
A23L1/08 - Honey; Honey substitutes
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Agent possessing antibacterial activity / 2278669
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Rejuvenating face cream / 2277954
Face cream with rejuvenating effect and including hyaluronic acid, vegetable oils, odorant, and water is characterized by that it contains as vegetable oils: soybean or corn oil, amaranth oil, jojoba oil, avocado oil, and, optionally, emulsion wax, complex of vegetable extracts, liposomal concentrate, isopropyl myristate, glycerol monostearate, apiary wax, lanoline, Germaben II, enzymatic vegetable complex, structural polysaccharides, wheat proteins, polyethylenesiloxane liquid (PES-4), D-Patenol, Allantoin, EDTA disodium salt, emulsifier, solvent, while water utilized is deionized water. All components are taken in specified proportions. Complex of vegetable extracts includes extracts of sunflower, oyster mushroom, oats, soybean, iris, white willow leaves, apple peel, citrus plants, rice, water pepperwort (Nasturtium officinale), and sweet almond (Amygdali dulcis semen).

FIELD: medicine, gynecology.

SUBSTANCE: invention relates to treatment of chronic inflammatory diseases of uterus cervix and vagina. Method involves administration of tampons with Baldonskaya mud by every other day by their alternating with intravaginal applications of the mixture consisting of 8-9 ml of avocado oil, 2-3 drops of tea tree oil with manuca and 1-2 drops of eucalyptus oil by 12 procedures for a course. Simultaneously the method involves oral administration of 1-2 drops of essential oil with honey that is drunk with green or mint tea and by alternating the using thyme, lemon and tea tree oils with manuca wherein each component is taken for 21 day with 14 days breaks between these administrations. Then after 3 months break 1-2 drops of lavender oil is given by the same schedule. On the background of above said therapy method involves application once per a week on the patient body the oil mixture consisting of 100 ml of basic oil, 7-8 drops of lavender oil, 6-7 drops of lemon oil, 9-10 drops of thyme oil and 13-15 drops of rosemary oil in combination in 2 h the bath comprising 2 table spoons of salt "San Aktiv", 5-6 drops of thyme oil, 3-4 drops of rosemary oil, 1-2 drops of lemon at temperature 37°C for 20 min. Such carrying out the method provides the effective therapy in women with allergy to antibiotics.

EFFECT: improved treatment method.

1 ex

 

The present invention relates to medicine, in particular to the gynecologist, can find application in the treatment of genital infections.

Currently installed pathogenic role of chlamydia, Mycoplasma, Gardnerella, viruses, anaerobes, and vector-borne infections in the occurrence of inflammatory diseases of the genital areas. In most cases, during the examination of the patients revealed a mixed infection in the form of two, three or more agents. The combination of infectious agents, the state of host determine the currents of modern inflammatory diseases of the reproductive organs of women. In the presence of diseases in the form of latent, oligosymptomatic, atypical forms of diagnosis and treatment is difficult, which leads to the chronicity of the process.

Lasting inflammatory process creates an unfavorable background or is the reason for the development of morphological changes in diseased tissue. Thus, in patients with chronic cervicitis with corporatelogo were identified changes to stratified squamous and columnar epithelium in the form of background cervical cancer and dysplastic processes mild to moderate severity, with transvaginal sonography and abnormal Doppler waveforms detected deterioration in local blood flow of the cervix.

Treatment of patients with diseases of initialnode tract - this is a difficult task, aimed at micro and macro. Therapy is always complex and individual. So, when Exo - and endocervicitis apply antibacterial, antitrichomonas, antifungal, antiviral, protivonematodoznye and other means depending on the data microbiological and special methods of research. Widely used local therapy etiotropic drugs whose action is directed to either one pathogen, for example, alpenarena ointment against viruses, dalacin - against chlamydia, ganapavaram against fungi, etc. or a combination of drugs aimed at the treatment of several infectious agents, such as Terzian, which, thanks to a combination of several substances affects the anaerobic flora, inhibit the growth of yeast-like fungi, acts on gram-positive and gram-negative bacteria, helps to arrest the symptoms of acute inflammation. In the medical complex includes immunomodulatory therapy, aimed at the various components of the immune system. To restore the normal vaginal flora apply eubiotics, to maintain metabolic processes multivitamins, enzymes. However, even long-term repeated therapy, especially when associated with virus infections, does not prevent chronical the process, the formation of persistent inflammatory changes in the sexual sphere (Weekrecently etc. KN. "Pathology of the vagina and cervix, M.: Medicine, 1997, pp.272, Prilepskaya V.N. et al. KN. "Diseases of cervix, vagina and vulva", 2nd ed., M: Medpress, 2000, 432 S., Skripkin J.K. and other "sexually transmitted Infections", prac. manual, M: Medpress-inform, 2001, s, Novikov A.I. and others, KN. "Sexually transmitted infections, and ectocervix", M.: Medicine, 2002, s).

When conducting causal chemotherapy often patients experience side-effects on the kidneys, liver, gastrointestinal tract and other organs, allergic reactions, development of dysbiosis different habitats: intestinal dysbacteriosis of a vagina.

The ineffectiveness of chemotherapy, complications of the physical condition of patients trigger the need for alternative methods and means of exposure to infectious agents, inflammatory genital processes.

The most practically widely used method of treatment of chronic inflammatory diseases of the cervix and vagina is a process involving the use of different antibiotics and metronidazole (journal cervical Pathology. Genital infection," Bayramov GV "Bacterial vaginosis" No. 1, 2004 p.40.

The disadvantages of the method are limiting the ability, due to the impossibility of its use in women with allergies to antibiotics, the inefficiency caused by the emergence of resistant strains of micro-organisms, allergic reactions, intestinal dysbacteriosis of a vagina.

The objective of the invention is a method of treating chronic inflammatory diseases of the vagina and cervix, allowing its use in women with allergies to antibiotics and to reduce side effects from therapy.

This problem is solved by the method lies in the fact that women in a day is introduced into the vagina Balkonsky dirt from vaginal swabs in the course of 12 treatments with applications in the vagina in between a mixture of essential oils avocado, tea tree, Manuka, eucalyptus, simultaneously turn 2 times a day for 21 days prescribed oral intake of oils of thyme, lemon and tea tree mixed with Manuka honey, serve with a green or mint tea, with breaks in the techniques of these oils within 14 days and after a three months of reception of lavender oil in the same pattern, applique on the whole body once a week on the background of therapy of a mixture of base oils with oils of lavender, lemon, thyme, rosemary and receive 2 hours bath containing a salt of San Asset, oil of thyme, rosemary and lemon.

Practically the method is as follows: vaginal shall anony Boldinskoi mud is heated in water at a temperature of 50-60° C, remove the pressure cap, the tip of the tube after the lubricating oil is injected into the vagina by squeezing the corrugated portion of the tampon dirt enters the vagina, where for 3 hours, and then removed by syringing boiled water. These procedures (12) to carry through the day. In the intervals between treatments at night is introduced into the vagina mixture of avocado oil (8-9 ml), tea tree oil with Manuka (2-3 drops) and eucalyptus oil (1-2 drops).

At the same time twice a day after meals for 21 days prescribed oral administration of thyme oil (1-2 drops) with honey (0.5 teaspoon), which is washed down with green tea or mint tea. After a break for 14 days according to the same scheme take lemon oil (1-2 drops), and then after 14 day break - tea tree oil with Manuka (1-2 drops). After a 3 month hiatus carried out according to the same scheme reception of lavender oil (1-2 drops).

Once a week on the background of therapy smear a woman's body with a mixture of base oil (optional patient) (100 ml), lavender oil (7-8 drops), lemon oil (6-7 drops), oil of thyme (9-10 drops), 13-15 drops of rosemary, and then after 2 hours, appoint a bath into which contribute Sol San Assets (2 tablespoons), thyme oil (5-6 drops), rosemary oil (3-4 drops), lemon oil (1-2 drops). Bath temperature 37°C, duration - 20 minutes after the bath, do not wipe.

Healing mud has pronounced biological properties of surface-active substances to bind to cover and penetrate into the cellular structure is cylindrical, transitional and squamous epithelium. Upon entering the cell debris can be a carrier of ions and whole molecules into the cells of the mucous membranes, transport of trace elements and molecules medicinal sources of natural origin, abundantly present in the mud vitamins, analogues, antibiotics, trace elements, amino acids and enzymes. Particles of some organic substances (organic acids, hydrogen sulfide, hydrocarbons, nitrogenous substances and others), circulating in the blood, have a direct effect on various organs and systems of the body. An important role in the physiological action of the dirt belongs to the connections estrogenically action. It increases the activity of some enzymes, resulting in accelerated oxidation-reduction processes, improve gas exchange, tissue respiration. Present in the mud biogenic stimulators activate cellular metabolism and regenerative processes. Inorganic chemical components absorbed by the mucous membranes, causing irritation of numerous receptors and blood vessels. Causing redness of the tissues, improve the trophic, circulation, metabolism, dirt way is there to pathological resorption products of inflammation. Arriving in the blood breakdown products of proteins are the type of autoprocedure, which causes the increase of protective forces of an organism. Dirt acts against microorganisms, violates the integrity of their cell membranes, binds the decay products, and promotes their excretion, without causing side effects. Dirt harmonizes microbial growth flora of the vagina, binds to pathogenic microorganisms, viruses, fungi, increases cellular resistance, sanitizes fabrics, has anti-inflammatory, desensibilisation and regenerating properties.

Essential oil:

- tea tree Manuka antiseptic broad-spectrum, also has analgesic, antifungal, antitumor activity, improves immunity;

- lemon - antiviral, antiseptic, strengthens the immune system, normalizes blood pressure, reduces cholesterol level in the blood, prevents the development of atherosclerosis, promotes the excretion of toxins, normalizes the gastrointestinal tract;

- thyme is antiseptic, anti-inflammatory, anesthetic, a powerful stimulator of the immune system, stimulates circulation, digestion, removes toxins;

- rosemary - antiseptic, analgesic, stimulant, stimulates bile secretion, normalizes the work of the intestines, improves coronary circulation, removes toxins;

- lavender is a strong antiseptic, and normalizes the nervous system, providing a sedative, analgesic effect, removes toxins, normalizes hormonal disorders of the reproductive system;

- eucalyptus oil is antibacterial, antiseptic and anesthetic.

Example

Patient Rustle Y.A., 32 years. From the anamnesis: the menstrual function is not compromised. Pregnancies - 1 abortion in 1992, when the period of 10 weeks, complicated endometritis treatment was conducted in outpatient conditions. The last 5 years from pregnancy is not protected. Infertility secondary. During examination: revealed HSV types 1 and 2, CMV infection; ultrasonic signs of chronic endometritis, cervicitis; colposcopy on the background of the stratified squamous epithelium was determined atypical yadegarynia zone, which was diagnosed as leukoplakia; they are 3 types: cells of the surface layer with moderate signs of inflammation and mild signs of dyskaryosis.

A course of treatment: vaginal swabs Boldinskoi mud 12 treatments a day, which was introduced in the vagina for 3 hours after heating in water at a temperature of 50-60°C for 3-4 minutes, then was removed by syringing with warm boiled water; in the intervals between the tampons in vagina introduced a mixture of oil, consisting of 9 ml of avocado oil, 3 drops of tea tree oil with Manuka and 2 drops of eucalyptus oil; at the same time for 21 days, morning and evening after meals were prescribed oral administration of 1 drop of thyme oil with 0.5 infant spoons of honey, drink green tea. After a break of 14 days after the scheme had an appointment 1 drop of lemon oil, and then after a 14 day break 1 drop of tea tree oil with Manuka. After a break of 3 months - 1 drops lavender within 14 days. Once a week on the background of this therapy the patient was treated with a mixture of 100 ml of sunflower oil Olein, 8 drops of lavender oil, 7 drops lemon 10 drops thyme oil, 15 drops of rosemary, and then the patient after 2 hours took over 20 minutes bath (37° (C) by adding 2 tablespoons of salt San Asset, 6 drops of thyme, 4 drops rosemary, 2 drops lemon, after leaving the bath the body was not dried prior to complete drying of the liquid on the surface of it.

After treatment: HSV and CMV infection in the cervical canal was not detected, ultrasound signs of inflammation of the endometrium and cervical canal was absent, colposcopy was visualized unchanged stratified squamous epithelium, they type 2 without morphological changes. The patient noted significant improvement of health and the disappearance of all complaints.

When treatment forbade the ΓΌ direct contact with sexual partners, drinking alcohol.

Treatment under the proposed method was performed in 30 patients. The duration of chronic inflammatory diseases of the cervix and vagina ranged from 1 year to 8 years. Patients have repeatedly held courses of conservative treatment, 3 were applied diathermocoagulation of the cervix, 2 - cryosurgery of the cervix, 1st - laser vaporization and the 1st coagulation cervical colovaginal.

When identifying patients

- complaints of vaginal discharge, discomfort, dyspareunia;

- infectious agents content cervical canal: in 4 patients was determined mixed urogenital, viral and bacterial, 2 - urogenital, 10 - mixed viral, 8 - monoporosa infection, fungal infection combined with viruses in 4 patients, with bacteria - 2, in 2 patients revealed papilloma virus infection (RSI);

- changes cytogram cervix. For differential diagnostic criterion of the degree of changes of the cervical epithelium was adopted they on PAP smears. 2 type sitarama characteristic of inflammatory diseases, installed in 10 patients. 8, having 2-3 type cytogram, on the background of the changes characteristic of inflammatory diseases, there was a structural cell disorders, 12, which they had 3 types, changed the I in cervical epithelium were interpreted as dysplasia mild (10) moderate (2) severity it is concluded the presence of chronic inflammatory diseases of the cervix and was determined indications for developed treatment method.

Contra-indications for treatment were acute inflammation, pregnancy, breast-feeding.

After treatment, all patients were absent previously shown complaints, improved General condition. When examining the contents of the cervical canal for the presence of infectious agents only 4 patients identified pathogenic flora: in 2 patients, who had a 3 and 5 of HPV types detected by the 1st type of the infection; in 2 patients, the planting of which was the growth of pathogenic numbers of enterococci and epidermal Staphylococcus, also in significant quantities identified the growth of Escherichia coli. Control cytological examination in all cases showed a significant improvement in cervical mucous. While in 6 patients is installed they type 1 for DADS, 6 - type 1-2, 18 - 2 type POPES without visible morphological changes, the latter was absent even in patients with HPV.

The effectiveness of treatment of chronic cervicitis, vaginitis was 87%.

A method of treating chronic inflammatory diseases of the cervix and vagina, namely, that a day is introduced into the vagina tampons with Ballons the second dirt, alternating with vnutrivlagalischnye appliques mixture 8-9 ml of avocado oil, 2-3 drops of tea tree oil with Manuka and 1-2 drops of oil of eucalyptus, 12 procedures for the course; at the same time twice a day orally administered 1-2 drops of essential oil with honey, which is washed down with green or mint tea, alternating the use of thoughts thyme, lemon and tea tree, Manuka, each of which is taken for 21 days, with a 14-day intervals between the injections, then after a 3 month break, enter 1-2 drops of lavender oil in the same pattern; on the background of therapy once a week make application to the body of the patient oil mixture consisting of 100 ml of a carrier oil, 7-8 drops of lavender oil, 6-7 drops of lemon oil, 9-10 drops of thyme oil and 13-15 drops of oil of rosemary, with a reception after 2 h baths with 2 tablespoons of salt San Asset, with 5-6 drops of thyme oil, 3-4 drops of rosemary oil, 1-2 drops of lemon oil, at a temperature of 37°duration 20 minutes

 

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