Method for predicting the development of postgastroresectional peptic ulcers |
|
|
IPC classes for russian patent Method for predicting the development of postgastroresectional peptic ulcers (RU 2304785):
Method for diagnosing parodontitis severity degree / 2280874
Method involves determining prostaglandin E2, arachidonic acid and phosphatidyl inositols in blood sample taken from patient gingiva. The mentioned substance levels data are interpreted in terms of severe, medium or light stage of the disease.
Method for predicting cholecystitis and cholelithiasis / 2263920
While diagnosing cholecystitis and cholelithiasis due to ultrasound testing one should additionally study blood plasma and bile to detect there the content of prostaglandins PGE2 and PGF2α. At PGE2/PGF2α ratio in blood plasma being equal to 6 and more, and, also, at decreased level of biliary cholecystokinin-pancreosimin by 38% and more, biliary PGE2 by 59% and more and increased level of biliary prostaglandin PGF2α by 5.9 times and more against the norm one should diagnose chlecystitis and cholelithiasis. The innovation enables to detect the above-mentioned diseases at earlier stage.
 The method of estimating severity of hemorrhagic fever with renal syndrome / 2155337
The invention relates to medicine, namely to the treatment of internal diseases
The method of treatment of patients of interval hypoxic training / 2110286
The invention relates to medicine, namely cardiology, and can be used for the treatment of cardiovascular diseases: coronary heart disease (CHD), hypertension, neuro-circulatory dystonia and other, and their complications (heart rhythm disturbance), as well as for the treatment of patients with low tolerance to emotional stress
Method for predicting the chance for osteomyelitis chronization in children / 2304784
During the moment of exacerbation and on ending the disease in question one should detect the content of alpha-1 proteinase inhibitor and alpha-1 acid glycoprotein in blood due to immunoturbidimetric technique. At decreased content of alpha-1 proteinase inhibitor from 2.3-2.6 g/l up to 1-1.2 g/l, and alpha-1 acid glycoprotein from 2.4-2.6 g/l up to 0.7-0.8 g/l one should predict the absence of osteomyelitis chronization. At decreased content of alpha-1 proteinase inhibitor from 2.9-3.1 g/l up to 1.8-1.6 g/l, and that of alpha-1 acid glycoprotein from 3-3.2 g/l up to 1.2-1.3 g/l one should predict osteomyelitis chronization. Application of the present method enables to predict the disease flow in shorter terms at high significance that provides the chance to prescribe the complex of efficient measures in due time which vary depending upon the disease flow.
Method for predicting the development of gestosis / 2304783
Starting from 22nd wk of pregnancy it is necessary to detect the concentration of neurospecific enolase and glyofibrous acid protein in blood serum. The development of gestosis in pregnant women should be predicted by the value of neurospecific enolase being above 12.4 ng/ml and glyofibrous acid protein being above 4 ng/ml. Moreover, severe gestosis should be predicted at the value of neurospecific enolase being 19 ng/ml and higher and glyofibrous acid protein being 10 ng/ml and higher. Application of the method enables to increase the accuracy of prediction.
Method for evaluating the results of surgical sanitation of inflammation focus in patients with chronic osteomyelitis / 2304781
The present innovation deals with laboratory investigations in case of traumatological pathology. One should simultaneously carry out microscopic investigation of material sample out of inflammation focus and blood from cubital vein to study the growth of microorganisms in the focus and in case of its absence and at registering positive index of digestion in blood with test culture S.aureus 209 P inside neutrophil after incubation, the value of IgM being 0.5-1.3 against the norm, the value of C-reactive protein being up to 12.0 mg/l it is possible to conclude upon satisfactory result of therapy conducted. Application of the present method enables to evaluate the degree of inflammatory process in bony tissue and, also, the state of phagocytic function of neutrophils as the first line of protection against microbial invasion.
Method for predicting the frequency of acute respiratory-viral infections due to evaluating the state of local immunity in children of primary-school age / 2303784
One should detect gamma-glutamyl transferase (GGT) in saliva sampled in the morning to an empty stomach. At GGT values being under 0.85 IU/l or above 3.4 IU/l it is possible to diagnose the decrease of local immunity in children and predict the risk for transferring a healthy child into the group of frequently sick patients. Application of the present method enables to predict the frequency of acute respiratory-viral infections (ARVI) before the procedure of prophylactic vaccinations, provides the chance for carrying out corresponding correction measures. The innovation is simple in application being noninvasive and could be applied in any age group.
 Method for quantitative determination of antibodies concentration specific to human endometrial tissue stromal cells antigen and in human biological fluid containing specific antibodies / 2303267
Method involves using the usual solid-phase enzyme immunoassay based on chemical binding antigen with microplate surface followed by placing antibodies-containing biological fluid on microplate, incubation, carrying out the color reaction and spectrophotometric evaluation of the color reaction indices. The end antigen is prepared by enzymatic hydrolysis of human normal tissue samples containing stromal cells of endometrial tissue. The enzymatic hydrolysis reaction is terminated by addition of chelating agent. Prepared mixed suspension of cells is centrifuged in continuous density gradient resulting isolation of stromal cells. Microsomal fraction of stromal cells is used as the end antigen that is diluted and bound covalently with microplate well surface. Then calibrating material prepared on basis of standard preparation antibodies specific to the end antigen is added into wells set, and biological fluid samples for analysis are added into another wells set. After carrying out the usual solid-phase enzyme immunoassay and using spectophotometry data a calibrating curve is plotted and the concentration of specific antibodies is determined using this curve. Invention provides the development of method for assay of antibodies amount specific to endometrial tissue stromal cells exceptionally that gives possibility for clinical diagnosis of autoimmune syndrome. Invention can be used in gynecology and obstetrics for diagnosis of autoimmune syndrome accompanying to clinical picture of endometriosis and other diseases in female reproductive system.
Method for predicting atrial fibrillation in cardiac ischemia patients / 2303266
Method involves applying immunoenzyme assay approach for analyzing blood for Chlamydia pneumoniae presence. Levels of inflammatory markers like C-reactive protein and tumor necrosis factor alpha are quantitatively determined. Seropositive result being the case with CRP level above 1.8 mg/l and TNF-α level above 2.4 pg/dl, atrial fibrillation occurrence is to be predicted.
Method for controlling climacteric disorders hormone replacement therapy safety in women in menopause period / 2303265
Method involves analyzing blood serum for alpha-2-glycoprotein associated with pregnancy taking concentration determined before administering hormone therapy for individual reference value and then, blood serum is analyzed once every half-year during the whole hormone replacement therapy application period. Alpha-2-glycoprotein associated with pregnancy having unchanged concentration or its concentration being increased by 50% when compared to the individual reference value, hormone replacement therapy application is to be continued. The concentration growing more than 50% high, when compared to the individual reference value, hormone replacement therapy application is to be prohibited.
 Method for identifying epitopes of t-cells and its using in preparing molecules of reduced immunogenicity / 2303264
Invention relates to a method for identifying epitopes of T-cells that induce the immune response in living organism-host. By this method immunogenicity-free biological compounds can be prepared or with reduced immunogenicity and in comparison with the corresponding unmodified object by decreasing or removing potential epitopes of T cells in limits of sequence of the parent immunogenic molecules. Also, invention relates to novel biological molecules being especially to proteins and antibodies prepared by the proposed invention. Invention provides reducing immunogenicity of biological compounds.
 Therapeutic application of selective inhibitors pde10 / 2303259
The present innovation deals with treating certain neurological and psychic disorders in mammalians including human beings and refers to the introduction of a selective inhibitor PDE10, moreover, the innovation in question deals with the ways to identify chemical compound that possesses he efficiency of a selective inhibitor PDE10. The innovation enables to develop new method for screening the compounds for the presence of the ability to selectively inhibit PDE10.
Method for determining community-acquired pneumonia clinical course severity degree / 2302637
Method involves determining reactivity worth of immunocompetent cells with cytokines level (IL-2,8, TNO-α).
 Method for predicting the character of bacterial keratitis flow / 2245553
In lacrimal liquid one should detect the content of interleukin 8 (IL-8) and that of interleukin 1 beta (IL-1β) to calculate prognostic coefficient (PC) due to dividing the first value by the second one by the following formula:
Method for detecting the sequence of applied lesions / 2245555
For the purpose to detect the sequence of applied lesions at availability of several wounds, scratches and ecchymoses on a cadaver one should study the activity of alkaline peptides isolated out of affected tissue by the impact of blood neutrophils of healthy donors upon phagocytosis. Moreover, the highest stimulating effect belongs to the peptides isolated out of the lesion applied earlier. The method enables to detect the sequence of applied lesions more accurately and differentiate the repeated lesion applied 5 min later, or more.
Method for biochemical detecting the degree of chronic hepatitis activity / 2246112
In blood serum one should detect the level of lactoferrin and biliary acids. At their ratio being equal to 5-17 it is necessary to detect chronic hepatitis of high activity.
 Early diagnosis method for diagnosing external genital endometriosis in women / 2247391
Method involves determining cathepsin D activity in endometrium bioptate. The value being equal to or less than 0.1 units of enzymatic activity per hour, external genital endometriosis is diagnosed.
Method for estimating enteric detoxication in the cases of generalized peritonitis / 2247392
Method involves studying lactoferrin content in blood serum and peritoneal exudates in postoperative period every day during the first three days. Lactoferrin concentration in blood serum being concurrently reduced by 0.02 mcmole/l or less and increasing lactoferrin concentration in peritoneal exudates by 0.04 mcmole/l or more, enteric detoxication is considered to be effective.
Method for diagnosing septic process and predicting septic complications development in children / 2248572
Method involves determining plasminogen/plasmin, α2-macro-globulin, α1-antitripsin content at the first, third, fifth and tenth day. The plasminogen/plasmin level being equal to 66-74 mcmole/l or 100-120 mcmole/l, α2-macro-globulin level of 2.7-3.0 mcmole/l, α1-antitripsin content of 2.38-3.2 mcmole/l, systemic inflammatory response to purulent infection, light severity degree endotoxicosis is diagnosed and favorable disease outcome is predicted. The plasminogen/plasmin level being equal to 50-65 mcmole/l or 125-160 mcmole/l, α2-macro-globulin level of 2.3-2.6 mcmole/l, α1-antitripsin content of 3.3-4.0 mcmole/l, sepsis with organ and system dysfunction, moderate severity degree endotoxicosis is diagnosed and septic complication availability and lingering disease development course is predicted. The plasminogen/plasmin level being equal to 39-40 mcmole/l, α2-macro-globulin level of 1.58-2.08 mcmole/l, α1-antitripsin content of 5.0-6.2 mcmole/l, severe sepsis, septic shock, severe degree endotoxicosis is diagnosed and unfavorable disease outcome is predicted.
 Method for detecting oxidized tryptophan metabolites at endogenic intoxication / 2249219
At testing one should precipitate high-molecular compounds with acetonitrile and register supernatant's spectral characteristics. Supernatant should be applied onto a paper filter, dried and put into solution containing aromatic aldehyde, acetone and concentrated hydrochloric acid taken at weight ratio of 70:5:1 to be kept for 2-3 min. Then it should be once again dried up to detect qualitative and semiquantitative content of oxidized tryptophan metabolites by intensity and chromatic shades. Moreover, by chromatic shades of yellow dyeing it is possible to detect the content of hydroxylated metabolites and by chromatic shades of violet dyeing - that of unhydroxylated ones.
|
FIELD: medicine, gastroenterology. SUBSTANCE: the present innovation deals with predicting the development of postgastroresectional peptic ulcers in patients due to detecting the level of gastrin after stimulation, pepsinogen, prostaglandins PGE2 and PG F2α, correspondingly, in mucosa of gastric stump and in mucosa of gastroenteroanastomosis. At increasing gastrin level up to 12.5 pM/l and higher, that of pepsinogen up to 10.0 mcg/l and higher and decreasing the level of prostaglandin PGE2 up to 570 and lower and at the decrease of prostaglandin PG F2α level up to 652 ng/g and lower one should predict the development of postgastroresectional peptic ulcer. Application of the present innovation enables to increase the accuracy in predicting the development of postgastroresectional peptic ulcers. EFFECT: higher accuracy of prediction. 3 ex
The invention relates to medicine and can be used to predict development-post gastro-resection peptic ulcers. A known method for predicting the development of post-resection syndromes for holding pelorosaurus options gastrectomy (Davydkin VI, Chapaev P.A. Disadvantages privatecoach operations. Jasper. the wedge. Gastroenterol. 2004. No. 1, page 195-199)adopted for the similar. There is a method of predicting post-resection syndrome by testing medical vagotomy and analysis of gastroduodenoscopy (jerlov G.K., Purse A.P. and other Organ and organomodified technology in the treatment of gastroduodenal ulcers. Railway experts. the wedge. Gastroenterol. 2004, No. 1, s). This method is adopted for the prototype. However, the known method is not sufficiently accurate, as it does not take into account the correlation factors of aggression and protection of the gastroduodenal zone. The aim of the invention is to improve the accuracy of forecasting-post gastro-resection peptic ulcers. The technical result is achieved that determine the level of gastrin after stimulation of pepsinogen, prostaglandins PG E2 and PG F2α, respectively, in the lining of the stomach stump and in the lining of the gastrojejunostomy, and when the level of gastrin to 12.5 pmol/l and above, pepsinogen to 10.0 µg/l or more, and red eye reduction the research Institute of the level of prostaglandin PG E2 to 570 ng/g and below and at the level of prostaglandin PG F2α to 652 ng/g and lower than forecast development-post gastro-resection peptic ulcers. The method is implemented as follows. The patient underwent resection of the stomach, was admitted with complaints of aching, cutting, stabbing, or dull pain that occurs intermittently or disturbing the patient constantly. Pain localized in the epigastric region with irradiation to the left shoulder or lumbar region, associated with food intake. In some cases, there had been painless form-post gastro-resection peptic ulcers. When esophagogastroduodenoscopy revealed changes of the esophageal mucosa in the form of edema and hyperemia, as well as a single point of erosion of the lower third of the esophagus. The detected edema hyperemia of the mucous membrane of the stomach stump. The radiological examination showed development of hypotension esophagus, cardia insufficiency. The stump of the stomach of the big sizes with no signs of deformation. Express evacuation of the barium suspension from the stump of the stomach, as well as slowing the emptying of the loops of the small intestine. Conducted biochemical studies of gastrin level after stimulation of pepsinogen, prostaglandins PG E2 and PG F2α, respectively, in the lining of the stomach stump and in the lining of the gastrojejunostomy. Found increased levels of gastrin to 12.5 pmol/l and above, pepsinogen to 10.0 µg/l or more, and the reduction of UB is nya prostaglandin PG E2 to 570 ng/g and below, reducing prostaglandin PG F2α up to 652 ng/g and below. Identify the signs and symptoms of gastric dyspepsia, radiographic evidence of a decline in motor function of the proximal and distal to the operated section of the digestive tract, changes in the level of gastrin, pepsinogen and prostaglandins E2 and F2αthat allows to predict the development-post gastro-resection peptic ulcers. Way of the following examples. Example 1. Patient K., 42 years old, underwent gastrectomy 6 years ago and was admitted with complaints of aching, dull pain that occurs periodically in the epigastric region with irradiation to the left shoulder, associated with food intake. Esophagogastroduodenoscopy revealed edema and hyperemia of the mucous membrane of the esophagus and gastric stump. Radiographically installed the hypotonia of the esophagus. The stump of the stomach of the big sizes. Evacuation of the barium suspension of the stomach stump accelerated. For biochemical analysis of the level of gastrin after stimulation of pepsinogen, prostaglandins PG E2 and PG F2α, respectively, in the lining of the stomach stump and in the lining of the gastrojejunostomy detected increased levels of gastrin to 12.5 pmol/l, pepsinogen to 10.0 ág/l, decrease prostaglandin PG E2 to 570 ng/g, reducing prostaglandin PG F2α up to 652 ng/,/p> The presence of radiographic evidence of a decline in motor function proximal to the operated section of the digestive tract, the nature of changes in the level of gastrin, pepsinogen and prostaglandins E2 and F2α allowed to predict the development-post gastro-resection peptic ulcers. The patient refused preventive treatment. Follow-up observations over the next 8 months revealed development-post gastro-resection peptic ulcers. Example 2. Patient, 45 years old, was admitted with complaints of sharp, stabbing pain in the epigastric region with irradiation in the region, associated with food intake. 8 years ago, I had a resection of a stomach. When esophagogastroduodenoscopy revealed changes of the esophageal mucosa in the form of edema and hyperemia, as well as a single point of erosions lower thirds. The detected edema and hyperemia of the mucous membrane of the stomach stump. X-ray examination: the hypotonia of the esophagus, cardia insufficiency, increasing the size of the gastric stump. Seen rapid evacuation of the barium suspension from the stump of the stomach, as well as slowing the emptying of the loops of the small intestine. Biochemical study of the level of gastrin after stimulation of pepsinogen, prostaglandins PG E2 and PG F2α, respectively, in the lining of the stomach stump and slimy is the gastrojejunostomy: the level of gastrin - of 15.3 pmol/l, pepsinogen - 12.5 µg/l, the level of prostaglandin PG E2 - 545 ng/g, the level of prostaglandin PG F2α - 638 ng/g Identify evidence of a decline in motor function of the proximal and distal to the operated section of the digestive tract, changes in the level of gastrin, pepsinogen and prostaglandins E2 and F2α allows to predict the development-post gastro-resection peptic ulcers. The patient refused preventive treatment, but a year later he was admitted again with endoscopically and radiographically visualized-post gastro-resection peptic ulcer. Completed the treatment. The ulcer healed. The patient was discharged in satisfactory condition. Example 3. The patient And, 29 years old, was admitted with complaints of feeling of heaviness in the epigastric region. Pain is absent. When esophagogastroduodenoscopy found edema of the mucosa of the esophagus and gastric stump. The radiological examination showed development of hypotension esophagus. The stump of the stomach increased, not deformed. Observed acceleration of the evacuation of the barium suspension of the gastric stump. Conducted biochemical studies of gastrin level after stimulation of pepsinogen, prostaglandins PG E2 and PG F2α, respectively, in the lining of the stomach stump and in the mucous gastroenterologist the oz. Found increased levels of gastrin to 14.7 pmol/l, pepsinogen to 11.3 µg, reducing prostaglandin PG E2 to 558 ng/g, reducing prostaglandin PG F2α to 645 ng/g Detect the presence of radiological evidence of a decline in motor function and proximal with respect to the operated section of the digestive tract, changes in the level of gastrin, pepsinogen and prostaglandins E2 and F2αthat allows to predict the development-post gastro-resection peptic ulcers. Over the next 1.5 years of painful sensations in the operated stomach did not arise. However, when control endoscopy revealed the presence-post gastro-resection peptic ulcers. Treatment. Control endoscopy revealed scarring of the ulcer. According to the claimed method produced prognostic assessment of occurrence-post gastro-resection peptic ulcers in 25 patients. The proposed method has improved the accuracy of the forecast development-post gastro-resection peptic ulcers based on the accounting ratios of the factors of aggression and protection of the gastroduodenal zone. A method for predicting the development-post gastro-resection peptic ulcers by biochemical studies of blood and esophagogastroduodenoscopy, characterized in that determine the level of gastrin after the stimulus is tion, of pepsinogen, prostaglandins PG E2 and PG F2α, respectively, in the lining of the stomach stump and in the lining of the gastrojejunostomy, and when the level of gastrin to 12.5 pmol/l and above, pepsinogen to 10.0 µg/l or more, and reducing prostaglandin PG E2 to 570 ng/g and below and at the level of prostaglandin PG F2α up to 652 ng/g and lower than forecast development-post gastro-resection peptic ulcers.
|