Application of blood photomodification in complex therapy of vaginal candidosis
FIELD: medicine, gynecology.
SUBSTANCE: one should carry out intrauterine photohemotherapy with the help of special equipment for 45-50 min, 5 seances. Moreover, for interrupting acute manifestations of vaginal candidosis it is necessary to conduct therapy with antimycotic preparations once daily for 3 d, and since the 3d-4th d one should perform intrauterine photohemotherapy every other day at the mode "II", after photohemotherapy it is useful to continue antimycotic vaginal therapy for 3 d more. For treating chronic, relapsing forms of vaginal candidosis therapy with antimycotic preparations should be fulfilled locally every other day by alternating it with intrauterine photohemotherapy at modes "II" and "III". In 1.5-2 mo after the course of therapy it is suggested to carry out repeated course of intrauterine photohemotherapy at the mode "III", every other day, 5 seances.
EFFECT: higher efficiency of therapy.
1 cl, 1 ex
The invention relates to medicine, namely to gynecology, and can be used to treat vaginal candidiasis.
Currently, there is a steady increase in the incidence of Candida infections. This is due to many factors: the impact on the human body changing environment, prolonged and uncontrolled use of antibiotics, corticosteroids, cytostatics, immunodeficiency States. Vaginal candidiasis is one of the most common manifestations of candidiasis, registered an average of 75% of women. Feature modern vaginal candidiasis is a long period of transition in relapsing forms. Most often affects women of reproductive age, in addition, vaginal candidiasis can occur in menopause and in childhood. For candidal infection is characterized by the presence of extragenital lesions (in the oropharynx, gastrointestinal tract), which exacerbates the course of vaginal candidiasis. Currently, treatment of vaginal candidiasis are used antimycotic drugs local and systemic action. Drugs local actions use pimafucin, clotrimazole, Gino-travogen and others, some authors propose to use the local influence of the laser radiation (KOREPANOV V.I. Laser therapy in obstetrics, gynecology, urology, Nephrology and proctology. M., 1998, p.20-21). Drugs for systemic effects include diflucan, Orungal, and others, and the duration of medication treatment can last up to 6 months. This treatment method has several disadvantages:
1. Funds General steps contraindicated in pregnancy, possess a nephro - and hepatotoxicity, cause allergic reactions, abnormal function of the gastrointestinal tract.
2. The most used antimycotic drugs causes suppression of the normal microflora of the vagina and intestines. There is a necessity to additionally use eubiotics, biogenic stimulators, vitamins, immunomodulators and other facilities conducive to the normalization of microflora of the vagina and intestines, broken antimycotic drugs.
3. To achieve stable remission requires long-term use of antimycotic drugs (3-6 months).
These problems in the treatment of vaginal candidiasis require a search for new, more effective methods to achieve good results in the treatment and prevention of relapses.
We have developed methods and intrauterine intravascular blood photomodification uses machine series HVAC-3 in certain modes (spectral range of 280-600 nm, the capacity of optical fiber is sky radiation at the end of the optical fiber 5 to 80 mW). The mode "I" allows you to photomodification blood part of long-wave ultraviolet (365-400 nm) and the predominantly visible light (400-600 nm). Mode "II" enables photomodification blood mainly to the long-wavelength ultraviolet radiation (315-400 nm) and visible light of 600 nm. Mode III provides the effect on blood mainly ultraviolet spectrum of optical radiation (280 to 400 nm).
For relief of acute manifestations are assigned antimycotic agent of local action in the form of vaginal suppositories (1 suppository vaginally 1 time a day for 3 days). At the same time carried out an additional survey of women (CBC, RW, HBsAg, prothrombin). With 3-4 days connected intrauterine photomodification blood. The patient is laid on the examination table, with uterine probe determines the patency of the cervical canal, its direction and size of the uterine cavity. Taking into account the received data sterile optical fiber is inserted through the cervical canal into the uterine cavity 1-2 cm behind her cervix. Fixation of the fiber is carried out by adhesive tape to the inner thigh. The procedure is recommended at intervals through the day, 5-7 sessions per course of treatment. The duration of the procedure 45-50 minutes. More effective is the use of "II" mode on the unit HVAC. The settlement of the e end of photochemotherapy assigned vaginal antifungal therapy (1 vaginal suppository 1 time a day for 3 days) followed by conventional control studies (DAB content vagina, culture, PCR). To prevent recurrence of the disease after 1.5-2 months a prophylactic course of intrauterine photochemotherapy apparatus HVAC mode "III" 5 sessions of 45-50 minutes each with an interval of a day. For the treatment of chronic, recurrent forms after a full examination, we recommend the following scheme: at intervals through the day to local treatment with antimycotic drugs (1 vaginal suppository 1 time per day) in alternation with the intrauterine photochemotherapy using the apparatus of the HVAC. Using modes "II" and "III" for 20-25 minutes on each mode, and the total treatment time is also 45-50 minutes. Required for a course of 5 sessions photochemotherapy. 2 months is a control examination of the woman and depending on results or repeats the above-described treatment, or is only photochemotherapy from relapse in order according to the methods of preventive course described above. Thanks to the peculiarities of the influence of blood photomodification uses on indicators of homeostasis in women with the inclusion of this method in the complex therapy of vaginal candidiasis is not required destination antimycotic funds systemic action.
EXAMPLE. Patient L., aged 26, complaints of itching, burning, cheesy vaginal discharge with an unpleasant, sour sophomorichumor: General condition is satisfactory. AD-120/70 mm Hg, heart rate of 76 beats per minute, satisfactory qualities. Examination of the vagina in the mirror: the vaginal mucosa hyperemic, swollen, covered with grayish-white bloom, highlighting abundant with cheesy-roscovitine inclusions. Analyses before treatment: complete blood count - er; HB 118 g/l; CPU 0,9; leukocytes 9000; e 2, P 8, L 28, 56, M 7, ESR 26 mm/h According to the stroke, seeding, Poland known C. Albicans. Diagnosed with vaginal candidiasis, acute form.
As of the preparation of the local action was assigned pimafucin on 1 suppository vaginally 1 time a day for 3 days. From the 3rd day began to hold intrauterine photomodification blood mode "II" apparatus HVAC, through the day, just 5 sessions of 45 minutes each session. From the 3rd day of treatment noted marked reduction in redness, swelling, itching. After photochemotherapy another 3 days was appointed pimafucin (vaginally 1 candle 1 time per day). After the 5th session photochemotherapy she recovered, disappeared cheesy discharge. No complaints. The presence of Candida infection according to the stroke, bacteriological seeding is not revealed. Complete blood count - er 3600000; HB 118 g/l; CPU 1,0; leukocytes 7700; e 1, P 2, L 25, 64, M 5, erythrocyte sedimentation rate of 13 mm/h 1.5 months was conducted anti-relapse intrauterine photochemotherapy using the apparatus of the HVAC mode "III", just 5 sessions of 45 minutely intervals through the day. Control tests were carried out after 6 months, the presence of Candida infection is not identified.
All were surveyed 210 women. All patients were divided into 2 groups - primary (132 patients) and control (78 patients). In the control group received standard scheme of drug therapy using drugs with systemic effects, but in the main group were carried out by local treatment with antimycotic drugs in combination with intrauterine photomodification blood. Follow-up of women was carried out after the end of treatment and after 6-8 months. As a result, the inclusion in the complex therapy of intrauterine photochemotherapy in the respective modes of the optical radiation can significantly reduce the number of recurrent candidal infection. In addition, patients of the main group are not signs of toxic effects on the body antimycotic drugs, as they were used only locally and within a short time.
Used in the treatment of vaginal candidiasis modes "II" and "III" of the HVAC-03 manifested by specific changes in indicators of homeostasis: activation of cellular and humoral immunity, normalization of blood rheological properties, normalization of acid-base status (KOS) and transmission function is of the blood, activation of hematopoiesis, a pronounced anti-inflammatory and antihistaminic effects. These clinical effects of photochemotherapy, normalizing metabolism and immune function, improve the efficiency of antimycotic drugs. In addition, the use of photochemotherapy promotes reduction of comorbidities and other risk factors of recurrence of the infection.
Thus, the proposed method of complex treatment of vaginal candidiasis in women improves the efficiency of the treatment of vaginal candidiasis due to the persistent effect of recovery, reduce the number of relapses of the infection. The application of this method shows high biological effect, improves the quality of life of patients.
1. The method of complex treatment of vaginal candidiasis in women through a combination of antimycotic funds and phototherapy, characterized in that the intrauterine photochemotherapy carried out using an apparatus HVAC for 45-50 min 5 sessions, and for relief of acute manifestations of vaginal candidiasis treatment antimycotic means carry out 1 time per day for three days, and spend 3-4 days intrauterine photochemotherapy through the day mode "II", after photochemotherapy three days spend antimycotic of vaginal the Yu therapy for the treatment of chronic, recurrent forms of vaginal candidiasis treatment antimycotic means spend locally intervals every other day, alternating with intrauterine photochemotherapy in the "II" and "III".
2. The method according to claim 1, characterized in that after 1.5-2 months after treatment, the course is repeated intrauterine photochemotherapy apparatus HVAC mode "III" through day 5 sessions.
FIELD: medicine, gynecology, surgery.
SUBSTANCE: one should introduce 3.5%-chitosan ascorbate gel into fistulous channel that contains metronidasol at the dosage of 2 mg/ml, at the volume up to 20 ml once/2 d till complete fistula's closing. The present innovation enables to activate reparative processes and fistulous epithelization that favors for closing fistulous channel in earlier terms.
EFFECT: higher efficiency of therapy conducted.
SUBSTANCE: method is accomplished in the following order. First, daily sanations of vagina with 0.06% sodium hypochlorite solution are fulfilled for 10 min, total number of procedures being 5. If clinical-laboratory symptoms of inflammation disappear, eubiotics are then introduced intravaginally. In case of persistence of clinical-laboratory symptoms of inflammation, dosage forms with antimicrobial agents are introduced intravaginally or introduction of the latter is combined with oral administration of antibacterial preparations followed by intravaginal introduction of eubiotics.
EFFECT: accelerated immunocorrection leading to reduced treatment course to combined effect of sodium hypochlorite, antibiotics, and eubiotics.
FIELD: medicine, gynecology, pharmacy.
SUBSTANCE: invention proposes using pimafucin (natamycin) as agent for treatment of bacterial vaginitis. Method for treatment of bacterial vaginitis involves intravaginal administration of pimafucin as 2% cream, 2 times per a day in morning and evening for 7-10 days and for first 3 days pimafucin-containing vaginal suppository in the dose 100 mg is administrated additionally in evening after administration of cream into vagina. Invention provides high effectiveness of treatment and clinical-etiological recovery in 92.3% of cases being without prescription of medicinal preparations. Method has no contraindications and can be used in all period of pregnancy and without adverse effects.
EFFECT: improved treatment method, enhanced effectiveness of agent and treatment.
2 cl, 1 ex
FIELD: medicine, gynecology.
SUBSTANCE: method involves using the following complex of medicinal agents: vaginal suppositories Hexicon, 1 suppository in the morning and night; Multitabs-maxi, 1 capsule, once per a day for 1 month; Eleutherococcus senticosus plant extract, 30 drops in the morning and in the daytime, before eating, for 2 months; Rokicen-RD, 1 spoon in the morning and night, 30 min before eating for 10 days and repeating this course of Rokicen-RD in 10 days. Invention promotes to arresting exacerbation disease for the shortest time on the background of absence of adverse effects and iatrogenic complications. Invention can be used for treatment of vaginal candidosis.
EFFECT: enhanced effectiveness of treatment.
FIELD: veterinary medicine.
SUBSTANCE: poultry's diet during the first and second phases of egg yield should be supplemented with roxazym enzymatic complex at the ratio towards husk-bearing components being 0.007 - 0.009 : 20. The present innovation prevents inflammation of oviducal vagina in laying hens.
EFFECT: higher efficiency of prophylaxis.
SUBSTANCE: method involves administering selective modulator of steroid sex hormones being in particular compounds of general formula(I) and some quantity of steroid sex hormones precursor selected from a group composed from dehydroepiandrosterone, dehydroepiandrosterone sulfate, androst-5-en-3β,17β-diol and compounds in vivo transformable into one of cited precursors. Bisphosphonates combined with selective estrogen receptor modulators and/or steroid sex hormones precursor are additionally introduced for medically treating and/or inhibiting osteoporosis progress.
EFFECT: enhanced effectiveness of treatment; excluded adverse side effects.
41 cl, 13 dwg, 4 tbl
FIELD: veterinary medicine.
SUBSTANCE: method involves exposing tendon and its sheath injury zone to laser radiation of pulse succession frequency equal to 512 Hz, power of 16 W for 6 min on the background of single intravenous Hyonate dose containing 40 mg of sodium hyalurate as active agent.
EFFECT: enhanced effectiveness of treatment; accelerated treatment course.
SUBSTANCE: method involves acting upon biologically active points. To do it, pathologically active orbital points are determined. The points are treated with infrared radiation in continuous mode until pathological activity is inhibited. Mirticam preparation is administered at a dose of 1 teaspoon three times a day after having taken meals.
EFFECT: improved vision acuity; increased accommodation reserve; normalized electrophysiological retina properties.
SUBSTANCE: method involves systemically introducing a photosensitizer followed by tumor irradiation with laser radiation. Laser radiation is applied in contact mode with 200-400 mW at the exit from light guide and applying pressure to tissue surface pretreated with glycerol with force of 0.1-0.5 kg/cm2 in tumor zone using micro lens.
EFFECT: enhanced effectiveness of treatment.
SUBSTANCE: method involves applying single stage 2 min long dual-channel low-intensity laser radiation action to blood vessels on neck and in sinocarotid zone (a. Carotis communis extra) and in projection to Gusser node (n. Trigeminus) on ill tooth side after having finished filling treatment. The first channel operates with red and infrared radiation. The second one operates with infrared radiation.
EFFECT: enhanced effectiveness in retaining pulp viability; stimulated blood vessel microcirculation, metabolism processes tissue feeding and regeneration.
SUBSTANCE: the present innovation deals with rejuvenating facial skin and correcting cicatrices. Initial laser treatment of facial skin should be carried out at impulse energy being 1000-1200 mJ till the appearance of single drops of "bloody dew". Further laser treatment should be conducted at laser impulse energy ranged 200-600 mJ. On finishing treating the skin with laser, before epithelization one should apply a mask made of transparent cotton tissue with "Aurobin" onto wound surface of patient's skin. One day later the mask should be removed. The innovation enables to prevent considerable lesions of epidermis' basal membrane at the stage of ablation, perform higher compression of collagen fibers at the stage of thermal contraction. The method suggested enables to fulfill treatment with the help of laser till maximally possible smoothing the wrinkles and cicatrices. The method enables to prevent skin infectioning after laser treatment and, also, accelerate the process of epithelization.
EFFECT: higher efficiency.
SUBSTANCE: method involves covering gingival mucous membrane with screen substance like wax or photocurable Koferdamm before applying laser radiation treatment. Water or 30-35% aqueous hydrogen peroxide solution is sprayed over dental surface or bleaching gel diluted with hydrogen peroxide is applied. The dental surface is next exposed to continuous diode laser radiation with wavelength selected from bandwidth of 800-970 nm during 15-300 s. Laser radiation power density belongs to bandwidth of 10-100 W/cm2. Radiation energy dose is in the range of 40-3000 J with dose density being equal to 200-20000 J/cm2 diode laser power being equal to 2.8 W, light beam diameter being equal to 3.5-5 cm when being 1 to 2 mm far from the dental surface. When exposed to laser radiation, the dental surface is uniformly scanned with laser beam.
EFFECT: enhanced effectiveness and safety of the procedure.
6 cl, 4 tbl
SUBSTANCE: method involves daily exposing pathological cicatrix area to visible bandwidth radiation according to remote treatment method setting gap equal to 0.5 cm in continuous mode acting with intensity of 50-75-100% issued by photodiode matrices first in blue of mean wavelength equal to 0.47 mcm and then red radiation is applied of mean wavelength equal to 0.67 mcm and with infrared radiation having mean wavelength equal to 0.98 mcm at the end. 3-5 sessions with each kind of radiation are given. Total exposure time is equal to 3-6 min per each field with total time equal to 9-15 min after preliminarily washing wounds with 1% Dioxidine solution. Then, procedures are carried out by acting with red light of wavelength equal to 0.67 mcm onto four exposure fields on thymus, on both sides of iliac bone wings area and regional paravertebral zone corresponding to wound localization in contact way in pulsating mode with frequency of 10 Hz and intensity of 100% 3-5 min long on each field. The course is 10-15 procedures long.
EFFECT: arresting local inflammation response in due time; accelerated granulation tissue formation; controlled recovery process.
SUBSTANCE: method involves applying photochromotherapy to pathological cicatrix area before carrying out ultraphonophoresis of 1% oil solution polar silt sulfide mud lipid extract covering cicatrix area. Daily treatment is applied in continuous contact mode using radiation of intensity equal to 75-100% issued by photodiode matrices first blue of mean wavelength equal to 0.47 mcm and maximum power of 32 mW, maximum power density is equal to 5 mW/cm2. Next to it, red radiation is applied of mean wavelength equal to 0.67 mcm and maximum power of 48 mW, maximum power density is equal to 7.5 mW/cm2. The cycle is concluded with infrared radiation treatment with mean wavelength equal to 0.98 mcm and maximum power of 112 mW, maximum power density is equal to 35 mW/cm2. 3-5 sessions with each kind of radiation are given. Total exposure time is equal to 9-15 min. Ultraphonophoresis procedure duration is 7-10 min.
EFFECT: improved cosmetic results; arrested inflammatory response in cicatrix zone.
SUBSTANCE: method involves covering ectocervix with Photodithazine photosensibilizer produced on the basis of glycamine chlorine salt E6 with active substance concentration being equal to 0.3-0.5% and holding it for 2 h. Laser radiation treatment is applied in continuous mode at wavelength of 660 nm and energy density of 80-200 J/cm2 supplied to wound during 8-20 min.
EFFECT: enhanced effectiveness of treatment; reduced risk of allergic response and adverse side effects.
SUBSTANCE: method involves introducing photosensibilizer into wound and exposing it to laser radiation. Photodithazine gel is applied as photosensibilizer based on glycamine chlorine salt E6 Photodithazine with active substance concentration of 0.5-1.5%. Laser radiation treatment is applied in continuous mode at wavelength of 660 nm and energy density of 30-40 J/cm2 supplied to wound and power density of 0.8-0.1 W/cm2.
EFFECT: enhanced effectiveness of treatment.
FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention describes new derivatives of triazole of the general formula (I): wherein X represents group of the general formula (II): wherein R' means halogen atom; R4 means (C1-C6)-alkyl; L means group of the formula: -La-Lb wherein La means a simple bond, oxygen atom, phenyl group that can be optionally substituted with halogen atom, cyano-group, (C1-C6)-alkyl, (C1-C6)-alkoxy-group or (C1-C6)-alkyl substituted with a single group -O-P(=O)(OH)2, naphthyl group, 5-membered heteroaryl group comprising as a heteroatom oxygen (O) or sulfur (S) atom, or (C3-C7)-cycloalkyl group that is substituted with carboxyl group; and Lb means (C1-C5)-alkylene group that can be optionally substituted with (C1-C6)-alkyl, carboxyl group or di-[(C1-C6)-alkyl]-amino-(C1-C6)-alkyl group; R means hydrogen atom, (C1-C6)-alkanoyl that can be optionally substituted with group: -Q-NR2'R3' wherein Q means a simple bond or carbonyl group, and R2' and R3' in common with nitrogen atom with that they are bound form piperazinyl ring substituted with (C1-C6)-alkyl and/or carboxyl group, or group: -O-P(=O)(OH)2; or their pharmacologically acceptable salts, pharmaceutical composition based on thereof, and a method for treatment of fungal infections.
EFFECT: valuable medicinal properties of compounds and composition, improved method for treatment of infections.
24 cl, 14 tbl, 1 dwg, 45 ex