Disinfectant |
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IPC classes for russian patent Disinfectant (RU 2238268):
 
 Synthesis of 3-amino-3-arylpropionate / 2225859
The invention relates to an improved process for the preparation of compounds of formula I
where R1represents aryl, heteroaryl, substituted aryl or substituted heteroaryl, and R2represents hydrogen, alkyl or aralkyl, or its salts, including the interaction of the compounds of formula II
where R1is such as described above, and R2'represents alkyl or aralkyl, with the compound of the formula III
where R5represents hydrogen or alkoxy, in conditions of reduced pressure, at the boiling temperature of the reaction solution (40 to 65 (C) in an inert solvent azeotropic distillation of water, the resulting compound IV
treated with gaseous hydrogen in the presence of palladium catalyst to obtain a compound V
which when interacting with acid to give a compound of formulas is alistor and transfer the obtained compound V by treatment with acid in the target product;
intermediate products for the synthesis of compounds I, the new compounds of General formulas IV and V
 Derivatives pyridyl, their enantiomers, cis - or trans - isomers and their salts and pharmaceutical composition / 2119915
The invention relates to new chemical substances possessing valuable properties, in particular derivatives pyridyl General formula (I)
 < / BR>where n is the number 2, 3, 4 or 5, A - uglerodsesola communication or unbranched Allenova group with 1 to 4 carbon atoms, unsubstituted or substituted by one or two alkyl groups, X - nitromethylene group, cyanomethylene group, unsubstituted or substituted by a residue R6with the following for R4values except tetrazole, or a group of formula =N-R7where R7is cyano, alkanesulfonyl group, phenylsulfonyl group, phenylalkylamine group, aminosulfonyl group, alkylaminocarbonyl group, dialkylaminoalkyl group, phenylcarbonylamino group, aminocarbonyl group, alkylaminocarbonyl group or dialkylaminoalkyl group, Y - alkoxygroup, fenoxaprop, allylthiourea, phenylthiourea or a group of the formula-R8NR9where R8means a hydrogen atom, an unbranched or branched alkyl group with 1 to 10 carbon atoms, which is in the 2nd, 3rd or 4th position can be C is POI or peredelnoj group, alkyl group with 1 to 4 carbon atoms, which may optionally be substituted with hydroxyl group in the 2 nd, 3rd or 4th position, cycloalkyl group with 3 or 4 carbon atoms, cycloalkyl group with 5-8 carbon atoms, in which one ethylene bridge can be replaced on-phenylenebis group, bicycloalkyl group with 6 to 8 carbon atoms, unsubstituted or substituted 1, 2 or 3 alkyl groups, adamantly group, alkoxygroup or trimethylsilylethynyl group, and R9is a hydrogen atom or an unbranched alkyl group, or R8and R9together with in between the nitrogen atoms form an unsubstituted or substituted by one or two alkyl groups or phenyl group, cyclic alkalinising with 4 to 6 carbon atoms, in which one ethylene bridge in the provisions of 3.4 can be replaced on-phenylenebis group, morpholinopropan or piperazinone, unsubstituted or substituted in the 4-position of the alkyl group with 1 to 3 carbon atoms or phenyl group, R1is a hydrogen atom or an alkyl group with 1 to 3 carbon atoms, R2and R3is a hydrogen atom or together form a carbon-carbon bond, Pyr - Peregrina group, unsubstituted or sameena the group, alkylaminocarbonyl group, dialkylaminoalkyl group, group, translated in vivo metabolic by carboxyl group or carboxyl group, if Y represents the group R8NR9where R8and R9have the above meaning, R5is a hydrogen atom or the halogen, alkyl, alkoxy or trifluoromethyl, all of the aforementioned alkyl and CNS remains, if nothing else is mentioned, have 1 to 3 carbon atoms, and, if nothing else is mentioned, all the above-mentioned phenyl nuclei may be mono - or tizamidine identical or different substituents from the group comprising an atom of fluorine, chlorine, or bromine, alkyl, hydroxyl, alkoxyl, carboxyl, phenyl, nitro-, amino-, alkylamino, dialkylamino, alkanolamine, cyano, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminoalkyl, trifluoromethyl, alkanoyl, aminosulfonyl, alkylaminocarbonyl and dialkylaminoalkyl,< / BR> their enantiomers, CIS - or TRANS-isomers, if R2and R3together denote a carbon-carbon bond, and their salts  Derivatives arylsulfonamides, mixtures of isomers, or individual isomers and their physiologically tolerated additive salts with bases, and a pharmaceutical composition having antidromically activity / 2096405
The invention relates to new derivatives of arylsulfonamides having, in particular, valuable pharmacological properties, more particularly to a derivative of arylsulfonamides General formula (I)
 < / BR>where R1benzyl, thienyl, chloranil, tetramethylene pentamethylbenzyl, phenyl, unsubstituted or monosubstituted by a halogen atom, a nitro-group, stands, metaxylem or trifluoromethyl, phenyl, disubstituted by chlorine atoms or methoxypropane, R2a hydrogen atom, methyl, R3pyridyl, R4and R5hydrogen atoms or together denote a carbon-uglerodnoi communication, R6hydroxyl, methoxyl, A group of the formula  < / BR>where R7and R8a hydrogen atom or together denote a methylene or ethylene group X N-methyl-aminogroup or sulfur atom, and the group-CHR7associated with the group-NR2-, B a carbon-carbon bond or unbranched Allenova group with 2-4 carbon atoms, their mixtures, isomers or individual isomers and physiologically tolerated additive salts with bases, if R6means hydroxyl, which  Salts of nitrogen-containing heterocyclic derivatives and 5 - hydroxynicotinic acid, which has antianginal and antiarrhythmic properties / 2067577
The invention relates to the synthesis of biologically active compounds, namely, salts of nitrogen-containing heterocyclic derivatives and 5-hydroxynicotinic acid of General formula:
 < / BR>where X 0(1a), CH2(1B), NH(1B)  Derived quinone or its pharmacologically acceptable salt / 2049776
The invention relates to a derivative of quinone f-ly I
 or its pharmacologically acceptable salts, where R1heteroalkyl group, in which heteroalkyl is a five - or six-membered cycle, containing as the heteroatom nitrogen and the alkyl portion contains 1 to 10 carbon atoms, B is carboxyl or protected carboxyl group, R3,R4,R5the same or different from each other and each represents a hydrogen atom, a hydroxyl group, a C1-C8alkyl, C1-C8alkoxy, C1-C8alkoxy, C1-C10alkyl, C1-C8alkoxy, C1-C8alkoxy, C3-C7cycloalkyl C1-C8alkoxy, thio C1-C8alkyl, thio C1-C8alkyl, except when R3and R4each is simultaneously the lowest C1-C8alkoxygroup, or a group represented by the formula II where R3,R4,R5have the meanings specified above, X and Y are the same or different and each represents a hydroxyl or C1-C8alkoxy
 Derivatives pyridyl, mixture of isomers, or individual isomers, or their physiologically tolerated salt additive having biological activity / 2028292
The invention relates to new chemical compounds with biological activity, in particular derivatives pyridyl General formula I
 _   where And communication, cycloalkenes and cycloalkylcarbonyl groups, each with 3-4 carbon atoms in which one methylene group can be replaced dichloromethylene group, an unbranched Allenova group with 2 or 3 carbon atoms, which may be single or multiply unsaturated group-R7CR8-, -O-R7CR8- or-NR9where R7is a hydrogen atom, hydroxyl, phenyl or an alkyl group with 1-3 carbon atoms; R8is a hydrogen atom or an alkyl group with 1-3 carbon atoms and R9is a hydrogen atom, an alkyl group with 1-3 carbon atoms or phenyl; X is carbonyl, thiocarbonyl or sulfonylurea group;R1is an alkyl group with 1-4 carbon atoms, unsubstituted or substituted phenyl group, cycloalkyl group with 5-7 carbon atoms, phenyl, naphthyl, biphenylyl, diphenylmethyl, indolyl, Tieni the group, in which the phenyl nucleus may be mono-, di - or tizamidine identical or different substituents from the group comprising fluorine, chlorine or bromine, alkoxy with 1-4 carbon atoms and an alkyl with 1-4 carbon atoms, and one of the substituents can also mean trifluoromethyl, carboxyl, amino - or nitro-group; R2is a hydrogen atom or alkyl with 1-4 carbon atoms; R3- pyridyl; R4and R5is a hydrogen atom or together denote a further carbon-carbon bond; R6is hydroxyl or alkoxygroup with 1-3 carbon atoms; n = 2,3 or 4, mixtures of their isomers or individual isomers and their physiologically tolerable additive salts (if R6means a hydroxyl group), which have valuable pharmacological properties, particularly an antithrombotic effect ![3r,5s-(+)-7-[4-(4-forfinal)-2,6 - aminobutiramida 5 - methoxymethyl-pyrid-3-yl]-3,5 - deoxyadenosyl acid in erythro-(e)-configuration in the form of a physiologically tolerable salt of the metal as an inhibitor of the biosynthesis of cholesterol](http://img.russianpatents.com/img_data/310/3104784-s.gif) 3r,5s-(+)-7-[4-(4-forfinal)-2,6 - aminobutiramida 5 - methoxymethyl-pyrid-3-yl]-3,5 - deoxyadenosyl acid in erythro-(e)-configuration in the form of a physiologically tolerable salt of the metal as an inhibitor of the biosynthesis of cholesterol / 2026290
The invention relates to substituted pyridine deoxyadenosyl acids, in particular to the new 3R,5S-(+)-7-[4-(4-forfinal)-2,6-aminobutiramida 5-methoxymethyl-PI - Reid-3-yl]-3,5-deoxyadenosine acid in Erythro-(E)-configuration in the form of a physiologically tolerable salt of the metal, which serves as an inhibitor of the biosynthesis of cholesterol
 Ionic liquids as solvents / 2189654
The invention relates to the regeneration of irradiated fuel and dissolution of metal oxides
 3-(cyclohex-3-enyl)pyridineboronic as corrosion inhibitor of steel in saline environments / 2168499
The invention relates to new chemical compound 3-(cyclohex-3-enyl)pyridineboronic, which can be used as corrosion inhibitor of steel in saline environments in the oil industry or in the circulating water supply systems
 2-methyl-3,4-trimethylenetrinitramine as corrosion inhibitor of steel in saline environments / 2168498
The invention relates to new chemical compound 2-methyl-3,4-trimethylenetrinitramine, which can be used as corrosion inhibitor of steel in saline environments in the oil industry or in the circulating water supply systems
 Alkyl(aryl)pyridineboronic as corrosion inhibitor of steel in saline environments / 2141948
The invention relates to novel alkyl(aryl)pyridineboronic formula I,
 < / BR>where R is C2H5C3H7C4H9C5H11C6H13C7H15or formula II,  < / BR>where R is CH3C2H5C3H7C4H9C5H11or formula III,  < / BR>where (a) R1= R4= CH3, R2= R3= CH3b) R1= R4= CH3, R2= C2H5, R3= CH3in) R1= R4= C3H7, R2= R3= CH3, g) R1= R4= C3H7, R2= C2H5, R3= CH3that are effective inhibitors of corrosion of carbon steels in environments with high oxygen content  Means causing inherited and fixed in the offspring directed matirovanie genome of the cells of unicellular and multicellular organisms / 2094460
The invention relates to biotechnology and may find application in medicine, veterinary, agriculture and food industry
 Derivatives of glycerol and method of production thereof / 2040521
The invention relates to new derivatives of glycerol General formula
 where k=1 or 0;Lower alkyl or arylalkyl; R1acetyl, 2-alkoxybenzyl or aryl; n=0 or an integer from 1 to 3; The group G formula  < / BR>or  X-A is selected from groups of formula: (1) -NH-(CH2)  where R2, R3and R4lowest alkoxygroup;(2) -NH-(CH2)  SO2-NH-R5where R5hydrogen, alkyl, or CH p=1 or 2;(3) -N  X-R6where the X group is-CH - or a nitrogen atom; R6group-СОR7where R7alkyl or alkoxy, or a group-0-C0-NH-R8where R8alkyl;(4) -NH  < / BR>(5) -NH-(CH2)3-OR10where R10alkyl; (6) -NH-(CH2)10-NH-CO-NR11R12where R11and R12lower alkyl; (7) -NH-CH  O(9) -NH-(CH2)5-0-(CH2)5-0-(CH2)5-H (10) -NH-(CH2)3-0-CO-NH-R14where R14alkyl; (11) -NH-CH  < / BR>(12)  CH where m=0 or from 1 to 6; R9, R15and R16the same or different and represent hydrogen or alkoxygroup, provided that when k=0, group a sure formula
 The sterilization method of injection solution of sodium chloride / 2238108
The invention relates to pharmaceutical industry and relates to a sterilizing composition for injection on the basis of sodium chloride
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(57) Abstract: The invention relates to the sanitizer air from a class of Quaternary ammonium compounds, which are a mixture of the chlorides alkylenediamine obtained by esterification at a temperature of 75-85C in the medium of organic solvent monochloracetic acid synthetic fatty alcohol fraction12-C14or12-C18or C16-C18when a molar ratio of 1.1:1 with subsequent interaction of the obtained alkylchlorosilanes with pyridine at a temperature of 80-90 ° C and a molar ratio of 1:1,0-1,1 for 6-9 hours and recrystallization of the final product of an organic solvent having a melting point of 98-s and chloride-ion content of 8.5-9.9 per cent. This disinfectant is used in medicine, agriculture, and home and has a disinfecting action against vegetative, capsule and spore forms of microorganisms. It has bactericidal activity against the test cultures of E. coli, S. aureus, Ps. acruginosa in a concentration of 0.5 wt.% when the exposure 60 min and bacteriostatic action against Bac.Subtilis at a concentration of 5 wt.% and exposure 120 min Technical gripes Arsenal domestic disinfectants. table 2. The invention relates to the field of disinfectants used in medicine for disinfecting medical instruments and equipment in a domestic environment for processing linen, tableware, furniture, floors in the premises where the patient in the poultry industry to reduce contamination of the air space for poultry, disinfection of hatching eggs, preventive and emergency disinfection of premises and equipment hatcheries and slaughtering poultry. Development of new disinfectants - relevant and practically important task. This is because the queries as health and other fields of application of disinfectants is growing, changing raw material capacity production, increased restrictions ecological character. The relevance of the development of new disinfectants related to the fact that recent microbiological studies have shown that when expressed selective ability of microorganisms can form resistance not only to antibiotics and disinfectants. In addition, the analysis of the Russian market shows that among the disinfectants that meet savremeni" and "Separador" (Israel), "Vaasan-2000" (Sweden), etc. The authors of the invention was to develop the domestic raw material base cheap and available highly efficient disinfectant, to reduce the share of expensive imported disinfectants. Currently, a large spread disinfectants from the class of Quaternary ammonium compounds. From this class of disinfectants the most famous alkyldimethylbenzylammonium, which is used as an independent disinfectant (A. Schwartz and other "Surface active agents and detergents", ed. Foreign literature, M, 1960, 152), and in the composition of the disinfectant compositions (patent RF №2146151, A 61 L 2/16, publ. 10.03.2000). Alkyldimethylbenzylammonium has a broad spectrum biocidal properties: it is active against both gram-negative and gram-positive microorganisms. The substance is odorless, soluble in water and has a detergent action. However it increased in comparison with other Quaternary compounds toxicity, strong irritant effect on mucous membranes and skin. The process of obtaining alkyldimethylbenzylammonium the chain (C10-C18). In Russia such amines are missing. This is a limiting factor in the process of creating modern domestic disinfectants class of Quaternary ammonium compounds, in particular of alkyldimethylbenzylammonium. As a disinfectant of the class of Quaternary ammonium compounds known also cetylpyridinium following structural formula Cetylpyridinium can be used as dezinfitsiruyuschee means individually (A. Schwartz and other "Surface active agents and detergents", ed. Foreign literature, M, 1960, S. 152) or disinfectant compositions (patent RF №2118174, A 61 L 2/16, publ. 27.08.1998). Cetylpyridinium is highly effective against vegetative and capsulorraphy microorganisms. He also combines disinfecting, cleaning and deodorizing action is low toxicity. Thanks to its properties is used in creams, ointments, skin treatment at the hands of the surgeon and the surgical field, and so on, However, the industrial implementation of the method of producing cetylpyridinium hampered tsutsujigaoka low quality causes the need for multiple stages of purification of the final product, what is-low-tech, leads to wasted solvents and does not provide the required for the purposes of medical quality of the product. The closest chemical structure and disinfectant properties to offer the sanitizer air from a class of Quaternary ammonium compounds is a disinfectant, which represents a Quaternary salt of the esters of pyridine, obtained by esterification fraction of synthetic fatty alcohols C10-C13or C10-C18or C17-C20monochloracetic acid, followed by mixing the received alkylchlorosilanes with pyridine, keeping the mixture at room temperature for several days, then washing with absolute ether and dried in a desiccator at first over sulphuric acid, and then over phosphorus pentoxide (article, So Pisco, O. C. Gudz, I., ^ in an interview and other "relationship between chemical structure and antimicrobial activity of Quaternary salts of esters of pyridine, picoline-N-methylmorpholin and triethylammonium acids". Physiologically-active substances, 18,1986, S. 14-18). Disinfectant prototype has sufficient disinfectant activity.connected with fact, that the product of the synthesis prototype is of poor quality and contains significant amounts of impurities: pyridine, alkylchlorosilanes and the source of alcohol. Pyridine increases the toxicity of the substances, as it belongs to the second class of hazardous chemical substances. The alcohol content makes alkylarylpolyglykelether hygroscopic, during storage, it absorbs moisture, hydrolyses selection of the appropriate alcohol and karboksimetilirovaniya and loses disinfectant activity. With regard to the production method, it is multi-stage, long; for the synthesis of the target product of satisfactory quality requires additional cleaning solvents. The output of alkylarylpolyglykelether does not exceed 40% due to low reaction rate under these conditions, and incomplete exhaustion of the initial reagents. From the point of view of industrial production-low-tech way. The technical result of the present invention is to expand the Arsenal of Russian highly effective disinfectants, obtained on the basis of domestic raw materials. With the aim of expanding Arsenal of Russian highly effective disinfectants predlagaet alkylenediamine, obtained by esterification at a temperature of 75-85C in the medium of organic solvent monochloracetic acid synthetic fatty alcohol fractions of C12-C14or C12-C18or C16-C18when the molar ratio respectively of 1.1:1 with subsequent interaction of the obtained alkylchlorosilanes with pyridine at a temperature of 80-90 ° C and a molar ratio of 1:1,0-1,1 and recrystallization of the final product of an organic solvent having a melting point of 98-S and the content of chlorine ions of 8.5-9.9 wt.%. Below are examples of the synthesis of these disinfectants. Example 1. Synthesis of alkylarylpolyglykelether based on fatty alcohol fractions of C12-C14 1.1. Synthesis of alkylchlorosilanes (alkyl (C12-C14) Alkylchloride get mixing in the reactor 154 g (0,8 mol) fatty alcohols fraction C12-C14(the company "Henkel") and 1.4 g (0,01 mol) of benzosulfimide (TU 6-1425-79). Then add 83 g (0,88 mole) monochloracetic acid (TU 6-01-13-90) and 310 g (3.5 mol) of toluene. The reaction mass is gradually heated on an oil bath until the temperature in the reactor 75-85C. The water formed in the reaction, Argonauts from the reactor in the form of utilizuyut 57 g of a 10% aqueous solution of sodium hydroxide at 20-25C, washed with water until the pH of the aqueous layer, is equal to 7. Distilled toluene under reduced pressure. After removal of the solvent VAT residue - alkylglycerol dispersed, collecting the fraction with a boiling point 120C/5 mm RT.article. Alkylchloride is colorless transparent liquid, with n201,4530. 1.2. Synthesis of alkylarylpolyglykelether In the mixed reactor 210 g (0,8 mol) of alkylchlorosilanes, 70 g (0,88 mole) of pyridine, 37 g (0,6 mol) of acetone containing 0.5 g (0,03 mole) of water. Heat the mixture for 6-8 hours on a boiling water bath up to 80-90 ° C, periodically switching off the stirrer to the decay of the resulting foam. After the termination of the foaming reaction mass thickens and the temperature in the reactor is reduced to 70-75S. This forms a crystalline product, which is recrystallized from a mixture of acetone:ethanol (10:1), filtered off, washed with a small amount of cold acetone, dried for 2-3 hours in vacuum at 35-45C (200 mm RT.cent.). Allocate 205-210 g (75 wt.% from theory.) the crystalline product is a light yellow color with a melting point of 100 S (determined according to GOST 18995-73) and the content of chlorine ions 9.9 wt.% (theoretically, of 10.4-9.6 per cent) (determined by the STP state unitary enterprise "Institute of polymers" 2-57-2000 mercurimetric or argentometric fraction C12-C18 2.1. Synthesis of alkylchlorosilanes (alkyl (C12-C18) Alkylchloride receive, as described in example 1.1, mixing in the reactor 94 g (1 mol) monochloracetic acid, 242 g (0,9 mol) fatty alcohols fraction C12-C18(THE 38.107119-85 or the company "Henkel"), 130 g (1.5 mol) of cyclohexane and 2,2 g (0,01 mol) of benzosulfimide. After distillation of cyclohexane alkylchloride cool, take samples for analysis and passed to the second stage without prior distillation. Get with a yield of 99 wt.% from theory. 318 g of alkylchlorosilanes is a colourless liquid with n20=1,4490-1,4500. 2.2. Synthesis of alkylarylpolyglykelether The reaction is carried out as described in example 1.2, mixing in the reactor 318 g (1 mol) of alkylchlorosilanes, 81.3 g (of 1.03 mol) of pyridine and 52 g (0,9 mol) of acetone containing 0.7 g (0,04 mole) of water. Upon completion of the reaction the mixture is cooled, is recrystallized from a mixture of acetone:ethanol, dried in vacuum at 40-45C for 2-3 hours. Get 300 g (yield 75 wt.% from theory.) the crystalline product is a light yellow color with a melting point of 98 1 0 2 and the content of chlorine ions of 8.9 wt.% (theoretically, of 10.4-8.9 per cent). Example 3. Synthesis of alkylarylpolyglykelether into fractions of alcohols C165 mol) fatty alcohol fraction C16-C18(THE 38.107119-85), 1,1 (to 0.007 mole) of benzosulfimide. Then add 53 g (of 0.55 mol) monochloracetic acid and 240 g (3 mol) of cyclohexane. The reaction is carried out as described in example 1.1. Get 160 g (95 wt.% from theory.) crystal alkylchlorosilanes. 3.2. Synthesis of alkylarylpolyglykelether In the reactor mixing 160 g (0.5 mole) of alkylchlorosilanes, 38 g (0.5 mol) of pyridine and 23 g (0.4 mole) of acetone containing 0.3 g (0,02 mol) of water. The reaction is carried out as described in example 1.2, heating the reaction mixture in a boiling water bath for 6 hours. After recrystallization from a mixture of acetone:ethanol = 10:1, and drying at 40-45C/200 mm RT.article get 155 g (78 wt.% from theory.) alkylarylpolyglykelether. Appearance - powder pink color, melting point 100-1 0 2, the content of chlorine ions charged 8.52 wt.% (theoretically, a 8.9-8.3 wt.%). Examples 4-6 (prototype) The reactor was mixed equimolecular number of components 1.6 g (0,02 mol) of pyridine and 6.38 g (0,02 mol) of alkylchlorosilanes, where alkyl WITH12-C14or of 7.68 g (0,02 mol) of alkylchlorosilanes, where the alkyl, C12-C18or of 7.68 g (0,02 mol) of alkylchlorosilanes, where the alkyl, C16-C18. The reaction mixture was stirred for 3 days PR is th diethyl ether. Dried first over concentrated sulfuric acid in a desiccator during the day, then the same over phosphoric anhydride. The product yield, respectively 2,82 g (38,83 wt.% from theoretical.), 2.8 g (of 36.5 wt.%) and 2.65 g (34,54 wt.%). Obtained according to examples 4-6 alkylarylpolyglykelether is commorancy product is yellow or brown color in the water dissolves poorly, pricing weak or missing. Physico-chemical properties are shown in table 1 Alkylarylpolyglykelether obtained in examples 1-3, is a solid white, yellowish or cream color with a melting point of 98 C and the content of chlorine ions of 8.5-9.9 wt.%; practically non-volatile compound, soluble in water with abundant foam. Alkylarylpolyglykelether, representing a mixture of the chlorides alkylpyridine, where alkyl WITH12-C14or C12-C18or C16-C18has the technical name of Alcatel" registered as a trademark (certificate No. 215975 from 26.04.2002,). As can be seen from the table, the content of chlorine ions in the inventive disinfectant and its melting point is higher than the proto high content in the inventive disinfectant main product and fewer impurities. By gas chromatography and NMR N'-spectroscopy confirmed the presence in the prototype appreciable quantities of pyridine, alkylchlorosilanes, the source of the alcohol. The presence of pyridine increases the toxicity of disinfectants, as it belongs to the second class of hazardous chemical substances. The presence as impurities of the source of the alcohols increases the hygroscopicity of disinfectants. During the storage of this substance it absorbs moisture, hydrolyses selection of the appropriate alcohol and karboksimetilirovaniya and loses disinfectant activity. The study disinfectant action obtained in examples No. 1-3 alkylarylpolyglykelether was carried out in the bacteriological laboratories of the Nizhny Novgorod regional MCSEs and Nizhny Novgorod state medical Academy on the methodology of the State scientific research Institute of epidemiology and Microbiology (VNIIEM) (Usacheva S. Y. Original method of studying the resistance of crops to disinfectants, 1988). The tests were carried out on aqueous solutions of alkarama concentration of 0.5, 1.0 and 5 wt.% at exposure of 60 minutes in relation to the following test cultures of microorganisms: - Ps.aeruginosa (representative capsulorraphy organisms); - You. Subtilis (spore-forming gram-positive bacilli). Below are the results of these tests. From the table 2 data shows that alkacetam has a disinfecting action against vegetative (E. coli and S. aureus), capsular Ps.acroginosa and spore-forming You.Subtilis forms of microorganisms. It has bactericidal activity against the test cultures of E. coli, S. aureus, Ps.aeruginosa in a concentration of 0.5 wt.% at exposure of 60 minutes and bacteriostatic action against Bac.Subtilis at a concentration of 5 wt.% and exposure to 120 minutes. Regarding the test of the test cultures of microorganisms alkacetam shows disinfectant activity at the level of a prototype. However, when the same disinfecting activity he shows a new quality: reduced toxicity and increased stability during storage of disinfectants. Thus, the invention achieves the main technical result - expanding Arsenal of domestic disinfectants with low toxicity and stability during storage. To obtain the claimed desiny puskat alkacetam with low cost and high volume. Alkacetam the level of acute toxicity when injected into the stomach is moderately hazardous compounds (III hazard class according to GOST 12.1.007-76). The drug does not accumulate in the body. In a concentration above 5 wt.% may have irritant effect. Used without PPE. Obscherezorbtivnymi and sensitizing properties of alkarama not found. Such properties of alkarama allow wide use as a disinfectant in medicine, life and agriculture. At the pilot plant Federal state unitary enterprise "Institute of polymers" acquired experimental-industrial batch of alkarama. Passed his test as a disinfectant for veterinary use on poultry farms "Nizhny Novgorod" (, Vorsma Nizhny Novgorod region), "Kostroma" (p/o Nikolskoye Kostroma region), "Sheksna" (named Argenta Vologda region). The test results are positive, which is confirmed by the acts and protocols. It is planned to continue joint work on the provision of modern poultry disinfectants. Also conducted clinical trials of alkarama in several hospitals in Nizhny Novgorod. Marked by a high disinfecting and washing properties of the drug, tststr CLASS="ptx2">The disinfectant from the class of Quaternary ammonium compounds, characterized in that it is a mixture of the chlorides alkylenediamine obtained by esterification at a temperature of 75-85C in the medium of organic solvent monochloracetic acid synthetic fatty alcohol fraction12-C14or12-C18or C16-C18when a molar ratio of 1.1:1 with subsequent interaction of the obtained alkylchlorosilanes with pyridine at a temperature of 80-90 ° C and a molar ratio of 1:1,0-1,1 within 6-9 h and recrystallization of the final product of an organic solvent having a melting point of 98-S and chloride-ion content of 8.5-9.9 per cent.
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![N-[alkylphenoxy(ethyleneoxy)carbonylmethyl]veteriany chlorides having the properties of corrosion inhibitors, as well as antibacterial, antiviral and antifungal activity, and the method of production thereof](http://img.russianpatents.com/img_data/70/709664-s.gif)
